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Dissertations / Theses on the topic 'Tissue specificity'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Mistry, Nitesh. "Human papillomavirus tropism : determinants of viral tissue specificity." Doctoral thesis, Umeå : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1149.

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2

Bartsakoulia, Marina. "Investigating the reversibility and tissue specificity of mitochondrial disorders." Thesis, University of Newcastle upon Tyne, 2017. http://hdl.handle.net/10443/3832.

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Mitochondrial disorders comprise a large group of heterogeneous disorders which are characterized by impairments in the cellular energy production. One of the great challenges of mitochondrial disease is the variety of clinical features present in patients. Mitochondrial disorders affect more than one organ leading to complex multisystem dysfunctions. Tissues, in which the metabolic demand is higher, such as skeletal muscle, neurons, liver or heart are typically affected. Mutations in both mitochondrial DNA (mtDNA) and nuclear DNA (nDNA) often lead to mitochondrial disorders. Although mtDNA en

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3

Dos, Santos Brilha Sara Sofia. "Tissue specificity of MMP gene expression and secretion in tuberculosis." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/51148.

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In tuberculosis (TB), matrix metalloproteinases (MMPs) have a major role in tissue destruction and cavitation. The composition of each extracellular matrix (ECM) gives specificity to tissues and is important in control of local immune responses by acting as a “molecular postcode”. Hence, it is likely to have important implications in TB. During central nervous system (CNS) infection, the effect of TB on blood-brain barrier (BBB) function is unknown. I hypothesised that the ECM environment may determine the MMP response during innate immune activation in pulmonary and CNS TB. I aimed to investi

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4

Ayala, Fierro Felix. "Tissue specificity for metabolism and toxicity of arsine and arsenite." Diss., The University of Arizona, 1999. http://hdl.handle.net/10150/284050.

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Accidental exposure to arsine (AsH₃) is possible in the semiconductor industry, metal mining, painting and herbicide preparation. First symptoms include intravascular hemolysis and dark red urine (hematuria), followed by abdominal pain, jaundice, and anemia. Exposure to AsH₃ is fatal in up to 25% of the reported human cases, usually caused by acute oliguric renal failure. The mechanism of AsH₃ toxicity in the kidney is unknown and was studied in vitro using established cell lines, primary cells, and isolated kidney. The hypothesis was that AsH₃ cause renal toxicity by its conversion to arsenit

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5

PELLEGRINI, Davide. "Development of high sensitivity and high specificity strategies for tissue microproteomics." Doctoral thesis, Scuola Normale Superiore, 2021. http://hdl.handle.net/11384/105431.

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Mass-spectrometry based proteomics has become an indispensable tool for molecular biology and clinical research because of its ability to identify and quantify thousands of proteins. When combined with laser capture microdissection (LCM), MS-based proteomics may be used to investigate disease-associated changes in the proteome of specific tissue regions or cell populations. Such specificity is essential because different anatomical regions often have distinct and diverse functions and may behave differently under pathological conditions. However, the number of proteins that may be identified a

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6

Yang, Rick L. "Tissue specificity of signal transmission and differential growth during maize root gravitropism." Connect to resource, 1992. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1244222463.

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7

Jia, Yizhen, and 贾亦真. "Bioinformatics study of the lineage and tissue specificity of genes and gene expression." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45540652.

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8

Freeman, Alistair Iain. "5' variants of glucocorticoid receptor mRNA : further studies of tissue-specificity and regulation." Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/24590.

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Glucocorticoids have diverse physiological functions: they affect central nervous system function, intermediary metabolism and restore homeostasis after stress. Secretion of glucocorticoids is regulated by the hypothalamic-pituitary-adrenal (HPA) axis; negative feedback at the hypothalamus and pituitary suppresses glucocorticoid secretion while the hippocampus exerts additional control over HPA axis activity. Glucocorticoids exert most of their actions, including negative feedback, via the glucocorticoid receptor (GR). The glucocorticoid sensitivity of a given cell/tissue is dependent on the l

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9

Wieser, Daniela. "Exploiting gene expression and protein data for predicting remote homology and tissue specificity." Thesis, University of Southampton, 2010. https://eprints.soton.ac.uk/159177/.

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In this thesis I describe my investigations of applying machine learning methods to high throughput experimental and predicted biological data. The importance of such analysis as a means of making inferences about biological functions is widely acknowledged in the bioinformatics community. Specifically, this work makes three novel contributions based on the systematic analysis of publicly archived data of protein sequences, three dimensional structures, gene expression and functional annotations: (a) remote homology detection based on amino acid sequences and secondary structures; (b) the anal

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10

Youngman, Kenneth R. "Mechanisms of regulation of polymeric immunoglobulin receptor expression: Cytokine induction and tissue specificity." Case Western Reserve University School of Graduate Studies / OhioLINK, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=case1057587491.

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11

Bashkeel, Nasser. "Human Gene Expression Variability and Its Dependence on Methylation and Aging." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/38988.

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The phenotypic variability in human populations is partly the result of gene polymorphisms and differential gene expression. Studying the variability of gene expression across human populations is essential to understanding the molecular basis for diversity. However, key issues remain unanswered with respect to human expression variability. For example, the role of gene methylation in expression variability is uncertain, nor is it clear what role tissue-specific factors may have. Moreover, the contribution that expression variability has in aging and development is unknown. Here we classified

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12

Roulis, Eileen V. "The genetic diversity of Chlamydia pneumoniae and its implications for host and tissue specificity." Thesis, Queensland University of Technology, 2016. https://eprints.qut.edu.au/96034/1/Eileen_Roulis_Thesis.pdf.

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Chlamydia pneumoniae is a wide spread human and animal pathogen, associated with a number of acute and chronic disease states. In this thesis, next-generation sequencing technologies were used to identify genetic markers involved in the diverse presentation of Chlamydia pneumoniae infections. The findings presented in this study describe a phylogenetically distinct human Chlamydia pneumoniae line, as well as a number of minor DNA sequence changes that may account for the biological fitness of particular strains to different diseases and animal hosts. The outcomes of this thesis have considerab

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13

Takahashi, Nozomu. "Functional analyses of tissue and organ specificity at the core of the arabidopsis circadian clock." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/456210.

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El reloj circadiano es un mecanismo celular responsable de la generación de ritmos biológicos con un periodo de 24 horas. La importancia de la función del reloj circadiano es evidente en casi todos los organismos estudiados hasta la fecha, desde bacterias hasta los seres humanos. Dado que las plantas son organismos sésiles, la función circadiana es particularmente relevante para su correcta adaptación al medio y supervivencia. Entender cómo el sistema circadiano de la planta se organiza en el contexto de células, tejidos y órganos surge como una de las preguntas fundamentales para comprender l

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14

Tang, Hailin. "Tissue specificity of a baculovirus-expressed, basement membrane-degrading protease in larvae of Heliothis virescens." [Ames, Iowa : Iowa State University], 2008.

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15

Pekowska, Aleksandra. "Epigenetic landscape of normal and malignant lympho-hematopoiesis : interplays between chromatin signature and tissue specific gene expression." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22011.

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La régulation transcriptionelle fine assurée par les Eléments Cis Régulateurs (ECR, eg. promoteurs et «enhancers») et les facteurs protéiques associés, est à la base de la mise en place et le maintien de l'identité tissulaire. Les modifications de la chromatine corrèlent avec l’activité d’ECRs et constituent l’épigénome de la cellule. Au cours de ma thèse, je me suis intéressée aux transitions des modifications des histones (H3K4me1/me2/me3, H3K36me3, H3K27me3 and H3K9me2) accompagnant le développement précoce de la cellule T. Pour cela, j’ai utilisé un modèle murin reproduisant une étape cruc

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16

Court, Naomi Wynne. "The subcellular localisation, tissue expression, substrate specificity and binding partners of stress-activated protein kinase-3." University of Western Australia. School of Biomedical and Chemical Sciences, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0084.

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[Truncated abstract] Cells need to be able to detect changes in their surrounding environment and transduce these signals into the appropriate cellular compartments. One of the major ways that the cell achieves this signal transduction is through the process of phosphorylation. Protein kinases are the enzymes responsible for catalysing this transfer of phosphate groups from ATP to amino acid residues of their specific substrates. A subfamily of serine/threonine kinases known as the Mitogen-Activated Protein Kinases (MAPKs) is essential in a diverse range of cell processes including growth, me

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17

Bergau, Anna. "Developing vectors for cystic fibrosis gene therapy : improving the longevity and tissue specificity of gene expression." Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424514.

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18

楊重文 and Chung-man Yeung. "Studies on the tissue specificity of the glucose-dependent insulinotropic polypeptide promoter by a transgenic mouse model." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31220204.

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19

Yeung, Chung-man. "Studies on the tissue specificity of the glucose-dependent insulinotropic polypeptide promoter by a transgenic mouse model /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B19098947.

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20

Petrie, Timothy Andrew. "Biomimetic integrin-specific surface to direct osteoblastic function and tissue healing." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/29628.

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Thesis (Ph.D)--Biomedical Engineering, Georgia Institute of Technology, 2010.<br>Committee Chair: Andres Garcia; Committee Member: Andrew Lyon; Committee Member: Barbara Boyan; Committee Member: Johnna Temenoff; Committee Member: Todd McDevitt. Part of the SMARTech Electronic Thesis and Dissertation Collection.

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21

Debela, Mekdes Haile Mariam. "Crystal structures of the human tissue kallikreins 4, 5, 7, 10, characterisation of their substrate specificity and analysis of their various zinc inhibition mechanisms." München Verl. Dr. Hut, 2007. http://d-nb.info/988422395/04.

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22

Cotsapas, Chris Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "The genetics of variation in gene expression." Awarded by:University of New South Wales. School of Biotechnology and Biomolecular Sciences, 2005. http://handle.unsw.edu.au/1959.4/30204.

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The majority of genetic differences between species and individuals have been hypothesised to impact on the regulation, rather than the structure, of genes. As the details of genetic variation are uncovered by the various genome sequencing projects, understanding the functional effects on gene regulation will be key to uncovering the molecular mechanisms underying the genesis and inheritance of common phenotypes, such as complex human disease and commercially important traits in plants and animals. Unlike coding sequence polymorphisms, genetic variants affecting gene expression will reside in

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23

Yuzda, Edward Stephen. "Chromaffin cell grafts to the cerebral cortex of nucleus basalis magnocellularis-lesioned rats : tissue specificity, duration of placement and establishment of immunocytochemical protocols." Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=55404.

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Cell transplantation to the brain and spinal cord is a well-established tool for studies on cellular and molecular mechanisms involved in development and plasticity. Experimental data from animals has suggested that restoration or preservation of function through cell transplantation has potential as a useful therapeutic approach in neurodegenerative disorders. Experimental evidence of graft-induced behavioral ameliorations has raised the question of the applicability of this technique to the cognitive neurodegenerative disorder, Alzheimer's disease (AD).<br>This present study is based on prev

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24

Nissi, R. (Ritva). "Prolyl 4-hydroxylase:genomic cloning of the human and mouse α(II) subunit, tissue distribution of type I and II isoenzymes, and cloning and characterization of a novel prolyl 4-hydroxylase from Caenorhabditis elegans". Doctoral thesis, University of Oulu, 2002. http://urn.fi/urn:isbn:9514267567.

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Abstract The collagens are a family of extracellular matrix proteins with a widespread tissue distribution. Collagen biosynthesis requires the hydroxylation of a number of proline residues by prolyl 4-hydroxylase. This posttranslational modification is essential for the synthesis of all collagens, as 4-hydroxyproline deficient collagens cannot form stable triple helices at body temperature. The genes for the human and mouse prolyl 4-hydroxylase α(II) subunits were cloned and characterized in this study. The human and mouse genes are 34.6 and 30.3 kb in size, respectively, consisting o

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25

Castagnola, Anaïs, Geraldine Mulley, Nathaniel Davis, Nicholas Waterfield, and S. Stock. "Transcript Abundance of Photorhabdus Insect-Related (Pir) Toxin in Manduca sexta and Galleria mellonella Infections." MDPI AG, 2016. http://hdl.handle.net/10150/622122.

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In this study, we assessed pirAB toxin transcription in Photorhabdus luminescens laumondii (strain TT01) (Enterobacteriaceae) by comparing mRNA abundance under in vivo and in vitro conditions. In vivo assays considered both natural and forced infections with two lepidopteran hosts: Galleria mellonella and Manduca sexta. Three portals of entry were utilized for the forced infection assays: (a) integument; (b) the digestive route (via mouth and anus); and (c) the tracheal route (via spiracles). We also assessed plu4093-2 transcription during the course of a natural infection; this is when the ba

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26

Julien, Solène. "Expression tissulaire des gènes paralogues : application au cerveau humain et à son état pathologique." Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS545/document.

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Dans l’histoire évolutive, deux gènes paralogues sont issus d’un évènement de duplication de leur ancêtre commun. Les gènes paralogues sont caractérisés par des duplications globales de génome (WGD) ou à petite échelle (SSD) et par leur datation. Les WGDs ont lieu à deux reprises à la base de la lignée des vertébrés. Les évènements de SSD ont lieu à plusieurs moments pouvant être plus récents, plus anciens ou contemporain de la période des évènements de WGD. La rétention des paralogues dans le génome, associée à une divergence de l’expression spatiale est une contribution importante pour l’aug

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27

Rosahl, Agnes Lioba. "How tissues tell time." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2015. http://dx.doi.org/10.18452/17113.

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Durch ihren Einfluß auf die Genexpression reguliert die zirkadiane Uhr physiologische Funktionen vieler Organe. Obwohl der zugrundeliegende allgemeine Uhrmechanismus gut untersucht ist, bestehen noch viele Unklarheiten über die gewebespezifische Regulation zirkadianer Gene. Neben ihrer gemeinsamen 24-h-Periode im Expressionsmuster unterscheiden diese sich darin, zu welcher Tageszeit sie am höchsten exprimiert sind und in welchem Gewebe sie oszillieren. Mittels Überrepräsentationsanalyse lassen sich Bindungsstellen von Transkriptionsfaktoren identifizieren, die an der Regulation ähnlich exprim

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28

Blotas, Clara. "Étude de la régulation à distance du gène CFTR." Electronic Thesis or Diss., Brest, 2025. http://www.theses.fr/2025BRES0009.

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Le gène Cystic Fibrosis Transmembrane Regulator (CFTR) code pour un transporteur ionique essentiel dans le maintien de l'homéostasie des cellules épithéliales. Un défaut de son expression conduit à des pathologies comme la mucoviscidose et les CFTR-related disorders (CFTR-RD). Les mécanismes moléculaires contrôlant l'expression tissulaire du gène ne sont pas entièrement compris, de même que les causes de l'hétérogénéité clinique. L'organisation spatiale du génome, qui dépend de l'état de la chromatine et des interactions entre promoteurs et éléments cis-régulateurs (CREs), est cruciale pour ga

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29

Lone, Yu-Chun. "Etude structurale du gene de la pyruvate kinase l et expression des sequences repetitives de type identificatrices id." Paris 7, 1988. http://www.theses.fr/1988PA077107.

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30

Ruffet, Marie-Line. "Étude biochimique et moléculaire des sérine acétyltransférases de la cellule végétale." Grenoble 1, 1995. http://www.theses.fr/1995GRE10083.

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Le but de ce travail a consiste a caracteriser sur les plans biochimique et moleculaire la serine acetyltransferase (sat). Cette enzyme est impliquee dans la synthese de la cysteine chez les plantes superieures. L'etude de la localisation intracellulaire de l'activite sat dans les tissus photosynthetiques a permis d'etablir que la cellule vegetale renferme au moins trois isoformes de sat distinctes localisees dans le chloroplaste, la mitochondrie et le cytosol. Cette compartimentation suggere que la synthese de la cysteine pourrait se derouler dans ces trois compartiments. L'isoforme chloropla

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31

Iratni, Rabah. "Régulation de l'expression de l'opéron ribosomique rrn des plastes d'épinard." Université Joseph Fourier (Grenoble), 1994. http://www.theses.fr/1994GRE10229.

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L'analyse de la repartition des transcrits de l'arnr16s de plastes d'epinard a permis d'observer une accumulation preferentielle de ces transcrits dans les cotyledons (organes photosynthetiques) par rapport aux racines (organes non photosynthetiques). Cette expression variable suivant les organes de la plante a pu etre associee a la presence de transcrits alternatifs inities au niveau des sites d'initiation de transcription pc et parnt-16s. Alors que parnt-16s est constitutivement represente, le transcrit pc est associe aux organes photosynthetiques. L'expression de l'arnr16s au niveau du site

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32

Baron, Agnès. "Etude de genes contenant une homeobox chez la souris : caracteristiques structurales, analyse transcriptionnelle dans l'espace et dans le temps chez l'embryon et chez l'adulte." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13033.

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La decouverte de l'homeobox: sequence d'adn, presente dans plusieurs genes jouant un role decisif dans la formation des structures de la drosophile et conservee dans des organismes aussi differents que les annelides, la souris et l'homme. Isolement de gene de souris contenant une homebox, en criblant une banque d'adn genomique. Six homeoboxes groupees sur une distance de 75 kilobases ont ete isolees, demontrant que la structure en complexes rencontree chez la drosophile et l'homme est conservee chez la souris. L'analyse de l'expression des homeo-genes a montre qu'elle etait restreinte a certai

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33

Franzetti, Bruno. "Structure, fonction et expression de la protéine ribosomique chloroplastique CS1." Grenoble 1, 1992. http://www.theses.fr/1992GRE10099.

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Le controle de l'initiation de la traduction est une etape importante de l'expression des genes chloroplastiques et fait intervenir, chez e. Coli, la proteine ribosomique (proteine-r) s1. Afin d'etudier l'etape d'initiation de la traduction chez le chloroplaste, nous avons caracterise chez spinacia oleracea une proteine (cs1) apparentee a la proteine s1. Nous avons isole un adnc codant pour le precurseur de la proteine-r cs1. Cs1 est considerablement plus courte que sa contrepartie bacterienne. Un noyau central homologue se compose de trois repetitions degenerees qui presentent de l'homologie

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34

Seboun, Eric. "Caracterisation chez l'homme et la souris d'un arn poly a**(+) transcrit dans la lignee germinale male, conserve dans l'evolution." Paris 7, 1987. http://www.theses.fr/1987PA077239.

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35

CHEN, WEIWEN. "Le recepteur de la cholecystokinine couple a la mobilisation du calcium intracellulaire : etude sur des cellules isolees d'acini pancreatiques et de muqueuses gastrique de rat." Paris 7, 1988. http://www.theses.fr/1988PA077035.

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36

Vauclare, Pierre. "Structure, biogenèse et expression de la protéine T du complexe de la glycine décarboxylase des plantes supérieures." Grenoble 1, 1996. http://www.theses.fr/1996GRE10051.

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Au cours de ce travail de these nous avons caracterise un adnc correspondant a la proteine t (1560 pb) du complexe de la glycine decarboxylase. Il possede un cadre de lecture ouvert de 1220 pb codant pour un peptide mature de 378 acides amines. La sequence primaire ainsi que la masse deduite (40 961 da) ont ete confirme respectivement par microsequencage et par mesure au spectrometre de masse. Dans la perspective d'une etude structurale, nous avons reussi a surexprimer chez e. Coli la proteine t en construisant un vecteur d'expression produisant un arnt rare chez les bacteries. L'etude de l'ex

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37

Spinazzi, Marco. "Optimized protocols for the analysis of mithocondrial respiratory chain enzymes in cells and tissues." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422449.

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Mitochondria are fundamental cellular organelles which decide about life and death of the cells. They are critically involved in a number of essential functions, including the production of energy through the respiratory chain enzymes, regulation of apoptosis, calcium metabolism and production of reactive oxygen species. Dysfunction of mitochondrial metabolism has been recognized a key player in a number of conditions, including mitochondrial disorders, diabetes, cancer, ageing, neurodegeneration and intoxications from drugs and poisons. Therefore, a reliable assessment of mitochondrial respir

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38

Bégot, Laurent. "Caractérisation du mutant dal1-2 d'Arabidopsis thaliana, affecté dans le développement précoce du chloroplaste." Université Joseph Fourier (Grenoble ; 1971-2015), 1999. http://www.theses.fr/1999GRE10054.

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Le mutant d'arabidopsis thaliana dal1-2, etiquete par un element transposable ac, est bloque precocement dans le developpement du chloroplaste. Son etude phenotypique a permit de mettre en evidence une couleur des feuilles variant du jaune au vert clair, au cours de son developpement. Morphologiquement, des coupes histologiques de feuilles montrent une desorganisation de la couche palissadique mesophyllienne. Le nombre de chloroplastes par cellule est plus important chez le mutant compare avec le sauvage mais leur taille est plus petite. La structure des chloroplastes par microscopie electroni

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39

Goula, Agathi Vasiliki. "Implication des lésions oxydantes et du mécanisme de réparation par excision de base dans la sélectivité tissulaire de l'instabilité somatique des répétitions CAG dans la maladie de Huntington." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00868694.

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La maladie de Huntington (MH) est une maladie neurodégénérative fatale, causée par l'expansion des répétitions CAG du gène de Huntingtine. La longueur de l'expansion est instable et proportionnelle à la gravité de la maladie. L'instabilité varie selon les tissus, p.ex. le striatum est très instable et dégénère, alors que le cervelet a une instabilité limitée et est épargné par la maladie. Nous avons étudié le rôle des lésions oxydantes et du mécanisme de réparation par excision de base (BER) dans la sélectivité tissulaire de l'instabilité dans ces deux tissus de souris R6/1. Le niveau des lési

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40

Cherrier, Marie. "La régulation de l'expression du gène de la Terminal déoxynucléotidyl Transférase (TdT) murine." Paris 6, 2004. http://www.theses.fr/2004PA066050.

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41

MARSCHAL, PHILIPPE. "Isolement a l'etat actif, specificite glycannique de deux lectines endogenes a mannose du tissu nerveux (csl et r1) et clonage de la lectine csl." Université Louis Pasteur (Strasbourg) (1971-2008), 1990. http://www.theses.fr/1990STR13135.

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Deux lectines endogenes, l'une soluble (appelee csl), l'autre membranaire (appelee r1), ont ete isolees du cervelet de jeunes rats, par un cycle d'extractions sequentielles et purifiees par chromatographie d'immunoaffinite, sous une forme active. Cette purification a permis d'aborder l'etude de leur specificite glycannique fine par des tests d'inhibition de l'agglutination des erythrocytes induite par ces lectines ou par l'utilisation d'une technique similaire a l'elisa. Ces tests, qui ont ete realises avec des mono-, oligo- et polysaccharides, ainsi qu'avec des glycoconjugues de structure con

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42

Rerra, Anna-Isavella. "Genome-wide analyses of signaling pathways controlled by steroid receptors." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ059.

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Les androgens(ADs) et les glucocorticoïdes (GCs) sont des hormones stéroïdiennes qui exercent des effets pléiotropes chez les mammifères. Leurs effets sont relayés par deux récepteurs nucléaires, le récepteur des androgènes (AR) et le récepteur des glucocorticoïdes (GR), respectivement. Même si les GCs sont fréquemment utilisés pour traiter les maladies inflammatoires et les antiandrogènes pour le cancer de la prostate, les traitements à long terme induisent des effets secondaires majeurs, notamment l'atrophie musculaire.Afin de préciser les mécanismes d’action de ces hormones, nous avons réal

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Yang, Young Joo. "The autophagosomal perspective: Tissue-specificity and cell-specificity of the autophagic response to starvation in vivo." Thesis, 2020. https://doi.org/10.7916/d8-9a2y-w195.

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Macroautophagy is a degradative system that cells employ to degrade proteins, lipids, pathogens or whole organelles. Dysfunctional autophagy has been implicated in diseases ranging from cancer to neurodegeneration. Animal models lacking macroautophagy fail to preserve a functional liver or central nervous system, supporting the importance of autophagy in maintaining the health of these tissues. However, it is unclear why this degradative pathway is critical in maintaining homeostasis. All macroautophagic cargo are sequestered by the multilamellar organelle called the autophagosome. The

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Wang, Chun Jen, and 王俊仁. "Exploring Tissue Specificity of ATM by using the Tet-on system." Thesis, 2002. http://ndltd.ncl.edu.tw/handle/95968405691162637005.

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碩士<br>國立清華大學<br>生命科學系<br>90<br>Ataxia-telangiectasia (A-T) is a recessive genetic disease that progressively and degenerately affects a startling variety of body systems. Several epidemiological studies have found that patients with A-T heterozygotes tend to have higher risk to develop epithelial carcinoma, especially breast carcinomas. Although tumorigenic mechanisms to explainthe occurance of tissue specificity is not clear, the gene responsible for A-T (ataxia-telangiectasia mutated;ATM) has been identified recently, and it is believed that ATM plays a key role In tumor suppression this dis

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Tanveer, M. "Tissue-specific reactive oxygen species signalling and ionic homeostasis in Chenopodium quinoa and Spinacia oleracea in the context of salinity stress tolerance." Thesis, 2020. https://eprints.utas.edu.au/35306/1/Tanveer_whole_thesis.pdf.

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Alongside with the drought, soil salinity is one the major environmental constraints that reduces crop growth and yield worldwide. According to recent reports, salinity stress is costing agricultural sector over US $27.3 billion per annum in lost revenues; which also aggravates the global food security. Improving salinity tolerance is a challenging task that requires understanding key physiological traits in naturally salt tolerant plant species. Halophytes are salt loving plants and they have very diverse array of physiological and biochemical mechanisms to encounter salinity stress. Therefor

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Ahmed, Ibraheem Ahmed H. "Tissue-specificity of ROS signalling and production in Sarcocornia quinqueflora in the context of salinity stress tolerance." Thesis, 2021. https://eprints.utas.edu.au/39482/1/Ahmed_Ibraheem_Ahmed_whole_thesis.pdf.

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Soil salinity is predicted to become more severe and widespread adding more challenges for sustainable crops production worldwide. Salinity stress tolerance is a complex trait, both physiologically and genetically, and halophytes represent a rich resource for understanding different strategies used by plants to cope with saline condition. While many previous studies explored various physiological and genetic aspects of salinity tolerance in halophytes, most of them were focused on annual species. However, this knowledge is hardly applicable to perennial crops that need to maintain capability o

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Wilch, Antonia. "Characterisation of genotypic and tissue specific resistance in oilseed rape (B. napus) against Sclerotinia sclerotiorum." Doctoral thesis, 2019. http://hdl.handle.net/21.11130/00-1735-0000-0005-12E0-9.

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Martinez, Hoyos Josefina. "Identification of the genes up- and down- regulated by the HMGA1 proteins: tissue specificity of the HMGA1-dependent gene regulation." Tesi di dottorato, 2007. http://www.fedoa.unina.it/1438/1/Martinez_Hoyos_Oncologia_Endocrinologia.pdf.

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Su, Chia-Hsin, and 蘇家興. "Dvelopment of a Novel Method for Cloning and Characterization of Methylated DNA sequence in Mouse Tissues: Analysis of Tissue-Specificity of CpG Methylation Sites from p53 Promoter to s27 Gene." Thesis, 2001. http://ndltd.ncl.edu.tw/handle/28596831501345806394.

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碩士<br>國立陽明大學<br>生物化學研究所<br>89<br>Abstract The covalent modification of DNA provides a direct and powerful mechanism to regulate gene expression. DNA methylation in eukaryotes involves addition of a methyl group to the carbon 5 position of the cytosine ring. This reaction is catalyzed by DNA methyltransferase in the context of the sequence 5’-CG-3’, which is also referred to as a CpG dinucleotide. It’s the most common eukaryotic DNA modification and is one of the many epigenetic mechanism. This special DNA marking has been closely associated with controlling the expression of houseke

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Wang, Ming-Shyong, and 王明雄. "The Zinc Specificity and Affinity of Zinc Binding Substance(s)in the Nuclei/Cell Debris Fraction of Digestive Tract Tissue of Common Carp, Cyprinus carpio." Thesis, 1999. http://ndltd.ncl.edu.tw/handle/84879866559466483153.

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碩士<br>國立海洋大學<br>食品科學系<br>87<br>Zinc concentrations in most tissues of animals and fishes were around 10~50 ppm; however, those in the digestive tract tissue of common carp were found to be extraordinarily high, being 300-500 ppm. It is also known that the nuclei/cell debris fraction was the major fraction responsible for these high concentration of zinc. In order to survey the specificity and affinity of zinc binding substance(s) in the digestive tissue of common carp, 65Zn was added to the Debris Fraction. Binding increased linearly with increase amounts of 65Zn. The Debris Fraction in the di

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