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Journal articles on the topic 'TKTD'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Lourenço, Vanessa S. C., Neusa L. Figueiredo, and Michiel A. Daam. "Application of General Unified Threshold Models to Predict Time-Varying Survival of Mayfly Nymphs Exposed to Three Neonicotinoids." Water 16, no. 8 (2024): 1082. http://dx.doi.org/10.3390/w16081082.

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Pesticide exposure patterns tested in laboratory bioassays often do not match real-world pesticide exposure profiles in edge-of-field waterbodies. Toxicokinetic–toxicodynamic (TKTD) models are therefore increasingly used, as they allow for predictions of the toxic effects under actual time-variable field exposures. The TKTD models from the General Unified Threshold models of Survival (GUTS), for example, are considered ready for use by regulators for calculating the survival rates for any time-variable exposure profile. However, questions remain regarding their predictive power for compounds s

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Koch, Josef, Silke Classen, Daniel Gerth, et al. "Modeling temperature-dependent life-cycle toxicity of thiamethoxam in Chironomus riparius using a DEB-TKTD model." Ecotoxicology and Environmental Safety 277 (June 2024): 116355. http://dx.doi.org/10.1016/j.ecoenv.2024.116355.

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3

Li, Huizhen, Qingping Lan, and Jing You. "Application of TKTD models in predicting time-resolved bioaccumulation and toxicity of pesticides to aquatic organisms." Aquatic Toxicology 286 (September 2025): 107489. https://doi.org/10.1016/j.aquatox.2025.107489.

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4

Martin, Thomas, Mark E. Hodson, and Roman Ashauer. "Modelling the effects of variability in feeding rate on growth – a vital step for DEB-TKTD modelling." Ecotoxicology and Environmental Safety 232 (March 2022): 113231. http://dx.doi.org/10.1016/j.ecoenv.2022.113231.

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Veltman, Karin, A. Jan Hendriks, Mark A. J. Huijbregts, Cédric Wannaz, and Olivier Jolliet. "Toxicokinetic Toxicodynamic (TKTD) Modeling of Ag Toxicity in Freshwater Organisms: Whole-Body Sodium Loss Predicts Acute Mortality Across Aquatic Species." Environmental Science & Technology 48, no. 24 (2014): 14481–89. http://dx.doi.org/10.1021/es504604w.

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Baudrot, Virgile, Sara Preux, Virginie Ducrot, Alain Pave, and Sandrine Charles. "New Insights to Compare and Choose TKTD Models for Survival Based on an Interlaboratory Study for Lymnaea stagnalis Exposed to Cd." Environmental Science & Technology 52, no. 3 (2018): 1582–90. http://dx.doi.org/10.1021/acs.est.7b05464.

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Nakayama-Kitamura, Kimiko, Yukari Shigemoto-Mogami, Marie Piantino, et al. "Collagen I Microfiber Promotes Brain Capillary Network Formation in Three–Dimensional Blood–Brain Barrier Microphysiological Systems." Biomedicines 12, no. 11 (2024): 2500. http://dx.doi.org/10.3390/biomedicines12112500.

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Background: The blood–brain barrier (BBB) strictly regulates the penetration of substances into the brain, which, although important for maintaining brain homeostasis, may delay drug development because of the difficulties in predicting pharmacokinetics/pharmacodynamics (PKPD), toxicokinetics/toxicodynamics (TKTD), toxicity, safety, and efficacy in the central nervous system (CNS). Moreover, BBB functional proteins show species differences; therefore, humanized in vitro BBB models are urgently needed to improve the predictability of preclinical studies. Recently, international trends in the 3R

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Cedergreen, Nina, Giulia Bellisai, Laia Herrero-Nogareda, Emil Boesen, and Kristoffer Dalhoff. "Using TKTD Models in Combination with In Vivo Enzyme Inhibition Assays to Investigate the Mechanisms behind Synergistic Interactions across Two Species." Environmental Science & Technology 55, no. 20 (2021): 13990–99. http://dx.doi.org/10.1021/acs.est.1c02222.

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Zhang, Hanzun, Shipeng Dong, Hongwei Shan, Chao Yang, and Fang Wang. "Application of the DEB-TKTD model with multi-omics data: Prediction of life history traits of Chinese mitten crab (Eriocheir sinensis) under different salinities." Ecotoxicology and Environmental Safety 290 (January 2025): 117635. https://doi.org/10.1016/j.ecoenv.2024.117635.

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Bart, Sylvain, Tjalling Jager, Stephen Short, et al. "Modelling the effects of the pyrethroid insecticide cypermethrin on the life cycle of the soil dwelling annelid Enchytraeus crypticus, an original experimental design to calibrate a DEB-TKTD model." Ecotoxicology and Environmental Safety 250 (January 2023): 114499. http://dx.doi.org/10.1016/j.ecoenv.2023.114499.

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11

Nordberg, Gunnar F., Alfred Bernard, Gary L. Diamond, et al. "Risk assessment of effects of cadmium on human health (IUPAC Technical Report)." Pure and Applied Chemistry 90, no. 4 (2018): 755–808. http://dx.doi.org/10.1515/pac-2016-0910.

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AbstractChemistry and Human Health, Division VII of the International Union on Pure and Applied Chemistry (IUPAC), provides guidance on risk assessment methodology and, as appropriate, assessment of risks to human health from chemicals of exceptional toxicity. The aim of this document is to describe dose-response relationships for the health effects of low-level exposure to cadmium, in particular, with an emphasis on causation. The term “cadmium” in this document includes all chemical species of cadmium, as well as those in cadmium compounds. Diet is the main source of cadmium exposure in the

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12

Bentz, Susanne, Theresa Pesch, Lutz Wolfram, et al. "Lack of transketolase-like (TKTL) 1 aggravates murine experimental colitis." American Journal of Physiology-Gastrointestinal and Liver Physiology 300, no. 4 (2011): G598—G607. http://dx.doi.org/10.1152/ajpgi.00323.2010.

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Transketolase-like (TKTL) 1 indirectly replenishes NADPH preventing damage induced by reactive oxygen species (ROS) formed upon intestinal inflammation. We investigated the function of TKTL1 during murine colitis and ROS detoxification for prevention of tissue damage. Mucosal damage in TKTL1−/− and wild-type (WT) mice was assessed by miniendoscopy and histology during dextran sodium sulfate (DSS) colitis. mRNA levels of interferon (IFN)-γ, inducible nitric oxide synthase (iNOS), interleukin (IL)-6, tumor necrosis factor (TNF), transketolase (TKT), and TKTL2 were determined by PCR and/or Wester

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Zhao, G., and M. E. Winkler. "An Escherichia coli K-12 tktA tktB mutant deficient in transketolase activity requires pyridoxine (vitamin B6) as well as the aromatic amino acids and vitamins for growth." Journal of Bacteriology 176, no. 19 (1994): 6134–38. http://dx.doi.org/10.1128/jb.176.19.6134-6138.1994.

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Nguyễn, Thị Lựu, та Minh Hùng Nguyễn. "Đặc điểm hạ đường máu ở bệnh nhân đái tháo đường type 2 có bệnh thận mạn giai đoạn 3 – 5". Vietnam Journal of Diabetes and Endocrinology, № 68 (13 червня 2024): 92–96. http://dx.doi.org/10.47122/vjde.2023.68.15.

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Mục tiêu: Mô tả đặc điểm hạ đường máu (HĐM) ở bệnh nhân đái tháo đường (ĐTĐ) type 2 có bệnh thận mạn tính (BTM) giai đoạn 3-5. Đối tượng và phương pháp nghiên cứu: Nghiên cứu cất ngang phân tích 147 bệnh nhân ĐTĐ type 2 có bệnh thận mạn tính giai đoạn 3 - 5 nhập viện vì HĐM hoặc HĐM trong thời gian năm viện từ tháng 7 năm 2021 đến tháng 9 năm 2022. Kết quả: Tuổi trung bình của bệnh nhân (BN) nghiên cứu: 68,9 ± 8,8. Thời gian mắc bệnh ĐTĐ trung bình là 16,7± 7,3 (năm), 61,9% BN trong nghiên cứu có thời gian mắc bệnh ĐTĐ ≥ 15 năm. 25,1% có tiền sử (TS) HĐM nặng, 41,5% BN CKD gå 4-5. 29,3%, 40% H

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15

Dorey, Emma. "TKT infringes again." Nature Biotechnology 19, no. 5 (2001): 400. http://dx.doi.org/10.1038/88032.

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Kim, Lại Vũ, Lê Thanh Hương, Đặng Đức Nhu та ін. "Phát hiện thực khuẩn thể tả trong môi trường nước ngoại cảnh tại một số tỉnh miền Bắc Việt Nam, 2018 - 2019". Tạp chí Y học Dự phòng 33, № 2 (2023): 29–41. http://dx.doi.org/10.51403/0868-2836/2023/1031.

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Nghiên cứu mô tả cắt ngang trên 800 mẫu nước môi trường ngoại cảnh tại một số tỉnh miền Bắc Việt Nam giai đoạn 2018 - 2019 nhằm mô tả sự lưu hành của thực khuẩn thể tả (TKTT) trong môi trường. Kết quả nghiên cứu cho thấy 8/400 TKTT phân lập được từ mẫu nước bề mặt chiếm tỷ lệ 2,0% và 2/400 TKTT được phân lập từ mẫu mồi gạc tôm chiếm tỷ lệ 0,5%. Kết quả xét nghiệm bằng phương pháp PCR cho thấy TKTT dạng sợi fs2 được phát hiện 10,5% đến 16,8% và TKTT dạng sợi fs1 được phát hiện từ 5 - 14,25% tùy thuộc loại mẫu nước bề mặt hay mẫu mồi gạc tôm. Kết quả phát hiện vật chủ Vibrio cholerae của TKTT đư

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17

Nurlaela, Rahmawati, and Suhendi Suhendi. "Evaluasi Manajemen Risiko Tata Kelola TI berbasis COSO ERM Intergrated Framework pada Perguruan Tinggi XYZ." Jurnal Informatika Terpadu 7, no. 1 (2021): 15–20. http://dx.doi.org/10.54914/jit.v7i1.316.

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Manajemen risiko tata kelola teknologi informasi (TKTI) sangat dibutuhkan oleh perguruan tinggi karena memiliki banyak keuntungan yang dapat membantu dalam mengelola risiko pada aspek TKTI. Sayangnya, manajemen risiko TKTI di Sekolah Tinggi Teknologi XYZ saat ini belum tersedia. Risiko TKTI pada kondisi saat ini dikelola secara manual, insidental, belum holistik, dan tidak berdasarkan konsep framework manajemen risiko. Hal tersebut menyebabkan sistem TKTI belum terorganisir dengan baik, sehingga dalam melakukan proses maintenance TKTI membutuhkan effort yang lebih. Salah satu contohnya adalah

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Fritz, Peter, Johannes F. Coy, Thomas E. Mürdter, German Ott, Mark Dominik Alscher, and Godehard Friedel. "TKTL-1 expression in lung cancer." Pathology - Research and Practice 208, no. 4 (2012): 203–9. http://dx.doi.org/10.1016/j.prp.2012.01.007.

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19

Muadz Hutahean, Muhammad Iqbal, Dian Purnama Sari, and Siti Wardah Pratidina. "Pengaruh Tunjangan Pegawai TKAD Dan Prosedur Kerja Terhadap Kinerja Pegawai TKAD Di PT. Bank Sumut Pusat Medan." Jurnal Ilman: Jurnal Ilmu Manajemen 11, no. 3 (2023): 40–47. http://dx.doi.org/10.35126/ilman.v11i3.528.

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Penelitian ini bertujuan untuk mengetahui apakah tunjangan dan prosedur kerja baik secara parsial maupun simultan memiliki pengaruh yang signifikan terhadap kinerja Pegawai TKAD di PT. Bank Sumut Pusat Medan dan seberapa besar persentasenya. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif dengan beberapa uji yakni reliability analysis, uji penyimpangan asumsi klasik dan regression linier. Berdasarkan hasil regresi data primer yang diolah dengan menggunakan SPSS 20, diperoleh persamaan regresi linier berganda sebagai berikut: Y = 5,040 + 0,332 X1 + 0,526 X2 + e. Secara pars

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20

Yoppy Mirza Maulana. "Model Keselarasan Bisnis dan TI untuk Perencanaan Tata Kelola TI berdasarkan COBIT 5." JURNAL FASILKOM 14, no. 1 (2024): 18–25. http://dx.doi.org/10.37859/jf.v14i1.6702.

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Tata kelola teknologi informasi (TKTI) merupakan pengelolaan TI dengan memastikan bahwa penerapan TI dapat meningkatkan kinerja dan mewujudkan tujuan organisasi. Adapun keberhasilan TKTI adanya keselarasan bisnis dan TI (Business-IT Alignment) atau dikenal dengan BITA. BITA merupakan suatu kondisi visi, misi, tujuan organisasi dapat didukung dengan adanya TI. BITA merupakan isu penting dalam perspektif para eksekutif, karena BITA dapat memaksimalkan investasi TI dan meningkatkan kinerja organisasi sehingga dapat mewujudkan tujuan organisasi. BITA dapat diimplementasikan dalam TKTI dengan dukun

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Nabilla, Anna, Raden Iis Arifiantini, and Bambang Purwantara. "Kualitas Semen Segar Sapi Bali Umur Produktif dan Non-produktif serta Penentuan Konsentrasi Krioprotektan dalam Pengencer Tris Kuning Telur." Jurnal Veteriner 19, no. 2 (2018): 242. http://dx.doi.org/10.19087/jveteriner.2018.19.2.242.

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The aim of this study was to compare the quality of Bali bull fresh semen in productive group (below 10 years old) with over productive group and to evaluate the frozen semen quality of bali bull after cryopreservation in Tris egg yolk extender using Dimethyl formamide (DMF) and glycerol in three different concentrations (5%, 6%, and 7%). Semen was collected using artificial vagina. Semen then evaluated macro and microscopically. Macroscopic evaluation conducted visually and microscopic evaluation with the aid of Computer Assisted Sperm Analysis CASA. Immediatelly after evaluation, semen were

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Antari, Nyoman Mega, Ida Bagus Gede Darmayasa, and Junita Hardini. "EFFECTIVENESS OF Trichoderma asperellum TKD WITH MEDIATOR OF MANURE TO CONTROL FUSARIUM DISEASE ON RED PEPPER PLANT (Capsicum annum L.)." SIMBIOSIS 8, no. 2 (2020): 63. http://dx.doi.org/10.24843/jsimbiosis.2020.v08.i02.p02.

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Cabai merah merupakan hasil pertanian di Indonesia yang sering terserang penyakit layu fusarium akibat F. oxysporum f.sp. capsici, sehingga dalam penelitian dilakukan pengendalian penyakit layu fusarium dengan menggunakan jamur T. asperellum TKD dan mediator pupuk kandang. Metode yang digunakan rancangan acak lengkap dengan 7 perlakuan P1 = Kontrol I (tanpa perlakuan); P2 = Kontrol II (F.oxysporum f.sp. capsici (penyakit)); P3 = penyakit + T.asperellum TKD 10 mL; P4 = penyakit + T.asperellum TKD 20 mL; P5 = penyakit + T.asperellum TKD 30 mL; P6 = penyakit + T.asperellum TKD 40 mL; P7 = penyaki

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., Yulnawati, and Herdis . "The quality of Garut ram liquid semen in Tris egg yolk extender to the sucrose supplementation." Jurnal Ilmu Ternak dan Veteriner 14, no. 1 (2013): 45–49. https://doi.org/10.14334/jitv.v14i1.362.

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The successful program of artificial insemination in sheep is determined by the quality of sperm that are used. Therefore, it is important to maintain the quality of sperm during and after storage in low temperature. The research was conducted to study the influence of sucrose in the Tris-yolk extender in maintaining the quality of Garut ram sperm during preservation in reaction tube for four days at 5Â°C. Ejaculated sperm was collected once a week for five weeks using artificial vagina from same ram. Semen was divided into four groups of extenders, i.e. Tris egg yolk 20% (TKT), TKT + 0,1% suc

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Tadesse, Michael Emru. "Benefits and challenges of practicing taekwondo to adolescents in Addis Ababa City, Ethiopia." Revista de Artes Marciales Asiáticas 11, no. 1 (2016): 1. http://dx.doi.org/10.18002/rama.v11i1.3310.

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<p>This study aimed at examining the benefits and challenges of practicing Taekwondo (TKD) to adolescents in Addis Ababa. In so doing, the study investigated the nature of TKD training, benefits of practicing TKD, and challenges/problems related with practicing TKD. A descriptive concurrent mixed methods research design was used. Accordingly, the quantitative part of the study had 108 TKD adolescent participants while the qualitative part had 12 participants (eight TKD adolescents and four TKD coaches), from four TKD clubs in Addis Ababa. Both one-stage cluster sampling technique and pur

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Akhadi, Iman. "PENGARUH BELANJA TRANSFER KE DAERAH DAN DANA DESA (TKDD) TERHADAP KETIMPANGAN PEMBANGUNAN DI INDONESIA." E-Jurnal Akuntansi TSM 3, no. 4 (2024): 197–212. http://dx.doi.org/10.34208/ejatsm.v3i4.2275.

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This research was conducted on the topic of the Influence of Regional Transfer and Village Fund Expenditure as government spending instruments in the state budget on Development Inequality in Indonesia. The study utilized Regional Transfer and Village Fund Expenditure (TKDD) data as the independent variable. Meanwhile, the dependent variables were the Regional Disparity Index (Williamson Index) and the Gini Ratio as representations of regional inequality in Indonesia. The data used consisted of panel data, including TKDD expenditure, per capita GRDP, and the population of each province in Indo

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Nguyễn, Xuân Trà, та Phương Chi Diệp. "Một Số Cơ Sở Khoa Học Cho Phát Triển Chương Trình Đào Tạo Ngành Thiết Kế Thời Trang Trình Độ Đại Học Dựa Trên Giáo Dục So Sánh". Journal of Technical Education Science, № 75B (28 лютого 2023): 55–65. http://dx.doi.org/10.54644/jte.75b.2023.1348.

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Chương trình đào tạo ngành Thiết kế thời trang (TKTT) bậc đại học ở Việt Nam tại các trường khác nhau còn thiếu tính thống nhất tương đối vì chưa dựa trên việc nghiên cứu sâu về các hồ sơ mô tả nghề. Sử dụng phương pháp nghiên cứu lý thuyết với tiếp cận của giáo dục so sánh, bài báo phân tích, so sánh 25 hồ sơ mô tả nghề TKTT của các nước phát triển được cung cấp trên các websites, kết hợp với phân tích, đối chiếu với mức độ đáp ứng những công việc điển hình của nghề TKTT trong chương trình đào tạo tại 08 trường đại học có uy tín ở Việt Nam trong đào tạo ngành này. Trên cơ sở đó, bài báo bàn l

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Xu, Zheng-Ping, Eric F. Wawrousek, and Joram Piatigorsky. "Transketolase Haploinsufficiency Reduces Adipose Tissue and Female Fertility in Mice." Molecular and Cellular Biology 22, no. 17 (2002): 6142–47. http://dx.doi.org/10.1128/mcb.22.17.6142-6147.2002.

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ABSTRACT Transketolase (TKT) is a ubiquitous enzyme used in multiple metabolic pathways. We show here by gene targeting that TKT-null mouse embryos are not viable and that disruption of one TKT allele can cause growth retardation (≈35%) and preferential reduction of adipose tissue (≈77%). Other TKT+/− tissues had moderate (≈33%; liver, gonads) or relatively little (≈7 to 18%; eye, kidney, heart, brain) reductions in mass. These mice expressed a normal level of growth hormone and reduced leptin levels. No phenotype was observed in the TKT+/− cornea, where TKT is especially abundant in wild-type

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Bacher, Ulrike, Claudia Haferlach, Wolfgang Kern, Torsten Haferlach, and Susanne Schnittger. "Prognostic relevance of FLT3-TKD mutations in AML: the combination matters—an analysis of 3082 patients." Blood 111, no. 5 (2008): 2527–37. http://dx.doi.org/10.1182/blood-2007-05-091215.

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We characterized the mutational status of the FLT3 tyrosine kinase domain (FLT3-TLD) in 3082 patients with newly diagnosed AML. FLT3-TKD mutations were detected in 147 of 3082 (4.8%) patients. Similar to the FLT3 juxtamembrane domain mutations (FLT3-LM), there was a high correlation of FLT3-TKD mutations with normal karyotype (88 of 1472; 6.0%). FLT3-TKD mutations were most frequent in the AML FAB subtypes M5b (15 of 114; 13.2%), M3v (6 of 51; 11.8%), and M4 (39 of 484; 8.1%). Similar to FLT3-LM, the FLT3-TKD mutations show elevated peripheral leukocytes compared with FLT3wt AML. FLT3-TKD had

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Wybenga-Groot, Leanne E., and C. Jane McGlade. "Sleuthing biochemical evidence to elucidate unassigned electron density in a CBL–SLAP2 crystal complex." Acta Crystallographica Section F Structural Biology Communications 77, no. 2 (2021): 37–46. http://dx.doi.org/10.1107/s2053230x21000911.

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The Src-like adaptor proteins (SLAP/SLAP2) bind to CBL E3 ubiquitin ligase to downregulate antigen, cytokine and tyrosine kinase receptor signalling. In contrast to the phosphotyrosine-dependent binding of CBL substrates through its tyrosine kinase-binding domain (TKBD), CBL TKBD associates with the C-terminal tail of SLAP2 in a phospho-independent manner. To understand the distinct nature of this interaction, a purification protocol for SLAP2 in complex with CBL TKBD was established and the complex was crystallized. However, determination of the complex crystal structure was hindered by the a

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Herdiyana, Deni. "Analisis Akuntansi Utang Transfer Ke Daerah Dan Dana Desa Pada UAPBUN Ba-999.05." Jurnal Maneksi 12, no. 4 (2023): 842–50. http://dx.doi.org/10.31959/jm.v12i4.1950.

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The study was conducted to analyze the implementation of payable accounting for transfer to the regions and village funds, and also comparing the accounting standards regarding transfers to the regions and village funds with the implementation carried out by UAPBUN BA-999.05. The research method used is a qualitative approach, namely literature study and descriptive analysis.The conclusion of the study is that in general the recognition, measurement, recording, presentation and assessment of TKDD have referred to the applicable regulations. However, there are differences in the recording of ac

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Marhäll, Alissa, Thomas Fischer, Florian H. Heidel, Julhash U. Kazi, and Lars Rönnstrand. "Internal Tandem Duplication (ITD) in the Tyrosine Kinase Domain of FLT3 Displays Higher Oncogenic Potential in Acute Myeloid Leukemia." Blood 128, no. 22 (2016): 5118. http://dx.doi.org/10.1182/blood.v128.22.5118.5118.

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Abstract Up to 30% of patients with acute myeloid leukemia (AML) harbor a mutation in FMS like tyrosine kinase 3 (FLT3). This mutation is not only the most frequent, but also the most clinically challenging, because it is associated with increased risk of relapse and poor overall survival. The most common oncogenic FLT3 mutation is the internal tandem duplication (ITD) in the juxtamembrane domain (ITD-JM). Other less frequently occurring mutations include ITD mutations in the tyrosine kinase domain (ITD-TDK) and point mutations in the TKD (e. g. D835Y-TKD). Use of FLT3 inhibitors has shown ini

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Farah, Farah Luthfia, Rahmat Mulyana, and Luthfi Ramadhani. "STUDI KASUS PENGARUH TATA KELOLA TI TERHADAP TRANSFORMASI DIGITAL DAN KINERJA BANK B." ZONAsi: Jurnal Sistem Informasi 4, no. 2 (2022): 100–116. http://dx.doi.org/10.31849/zn.v4i2.11085.

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Disrupsi teknologi digital, peningkatan kompetisi, perubahan perilaku pemangku kepentingan, serta pengaruh pandemi COVID-19 telah membuat banyak perusahaan incumbent berinvestasi menjalankan Transformasi Digital (TD). Namun banyak terjadi kegagalan TD yang diduga disebabkan oleh kurangnya praktik tata kelola yang baik. Riset sebelumnya telah menunjukan peranan Tata Kelola TI (TKTI) untuk peningkatan Kinerja Organisasi (KO). Tapi belum ada penelitian mengenai pengaruh mekanisme TKTI (struktur, proses, relasional) terhadap kesuksesan TD dan KO. Bank B dipilih karena perbankan sangat terdampak ol

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Kim, Minkil, Minkil Kim, and Minkil Kim. "A case study on service quality perceptions and member retention towards Taekwondo participants in North America." IJASS(International Journal of Applied Sports Sciences) 33, no. 2 (2021): 248–62. http://dx.doi.org/10.24985/ijass.2021.33.2.248.

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COVID-19 continues to represent the challenge to Taekwondo (TKD) schools. TKD schools have been closed and faced with decreasing participants due to the Pandemic. The purpose of this study is to examine the extent to which service quality factors predict member intention for renewal in TKD schools. The target population evaluated for this study consisted of individuals aged at least 18 years or older who had attended a TKD schools. This study conducted for TKD members in the U.S.. A total of 159 participants were recruited via both in-person and online surveys. This study revealed that TKD mem

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Tadesse, Michael Emru. "The role of taekwondo training on the subjective wellbeing of adolescents in Addis Ababa, Ethiopia." Revista de Artes Marciales Asiáticas 10, no. 2 (2015): 72. http://dx.doi.org/10.18002/rama.v10i2.1758.

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<p>The purpose of this study was to investigate the role of taekwondo (TKD) training on the subjective well-being (SWB) of adolescents (12-18 years old) in Addis Ababa city. A cross-sectional survey method was used; self-administered questionnaire was the main data collection tool. A total number of 162 adolescents (108 TKD adolescents from four randomly selected TKD clubs and 54 non-TKD adolescents from a randomly selected public high school), participated in the study. The study sought to determine TKD adolescents’ level of SWB as measured by the Personal Wellbeing Index – School Child

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Suleman, Sherzad Khudeida, Nizer Yahya, Stefan Nilsson, and Karin Enskär. "Comparative efficacy of pharmacological and non-pharmacological interventions for mitigating pain and anxiety associated with venipuncture: a randomised controlled trial." BMJ Paediatrics Open 8, no. 1 (2024): e002881. http://dx.doi.org/10.1136/bmjpo-2024-002881.

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BackgroundVenipuncture is one of the most commonly performed medical procedures in paediatric care, but it can also be one of the most painful and distressing experiences for patients. Finding effective strategies to manage pain and fear associated with venipuncture is crucial for improving the paediatric patient experience and promoting positive health outcomes. This study aimed to evaluate the efficacy of a combined approach using a topical analgesic cream (TKTX cream) and a distraction technique (Trace Image and Colouring for Kids-Book, TICK-B) in reducing pain intensity and fear levels in

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Qoriatul Zahro, Miftahul Nur, Dewi Muthmainnah, Aisyah Azzahra, and Elina Intan Apriliani. "Peran Profesionalisme Guru Dalam Meningkatkan Kemandirian Anak Usia Dini di TKTQ Al Hikmah Boyolali." Indonesian Journal of Early Childhood: Jurnal Dunia Anak Usia Dini 6, no. 1 (2024): 192–97. http://dx.doi.org/10.35473/ijec.v6i1.2879.

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This research aims to find out the role of teacher professionalism in increasing the independence of young children at TKTQ Al Hikmah Boyolali and what factors hinder the development of children's independence. The method used is descriptive qualitative. The research subjects used were class teachers and the principal at TKTQ Al Hikmah Boyolali. Data collection techniques use interview and observation techniques. The results of the research conducted show that the role of teacher professionalism in increasing children's independence at TKTQ Al Hikmah Boyolali is very good where teachers carry

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Sholikhatin, Siti Alvi, Adi Budi Prasetyo, and Ade Nurhopipah. "IMPLEMENTASI ALGORITMA KRUSKAL DAN ALGORITMA PRIM SUATU GRAPH DENGAN APLIKASI BERBASIS DESKTOP." Jurnal RESISTOR (Rekayasa Sistem Komputer) 3, no. 2 (2020): 89–93. http://dx.doi.org/10.31598/jurnalresistor.v3i2.638.

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A graph has several algorithms in its solution, including the Kruskal algorithm and Prim algorithm, both of which are greedy algorithms for determining the minimum spanning tree. Completion of graphs is useful in various fields of life, so an accurate graph calculation is important. Making an application to solve a graph, especially the Kruskal algorithm and Prim algorithm aims to facilitate the work of the graph so as to produce an accurate final result. The flow of research carried out are: a background review of research, study of literature and relevant literature, application design, buil

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Yasti, Miftah Amalia, Liza Andriani, Yuliza Anggraini, et al. "PENGABDIAN KEPADA MASYARAKAT INTERNASIONAL: MEMBERIKAN TERAPI KELOMPOK TERAPEUTIK UNTUK MENINGKATKAN STIMULASI MOTIVASI ANAK DALAM BELAJAR." MONSU'ANI TANO Jurnal Pengabdian Masyarakat 8, no. 1 (2025): 13–20. https://doi.org/10.32529/tano.v8i1.3760.

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Pemberian stimulasi di lingkungan sekolah sangat efektif mengoptimalkan perkembangan anak karena hampir sepertiga waktu anak dalam satu hari dihabiskan di sekolah. Terapi Kelompok Terapeutik (TKT) dilakukan untuk belajar bagaimana stimulasi sesuai perkembangan anak sehingga membantu mengoptimalkan perkembangan psikomotor anak usia sekolah. PKM Internasional yang dilakukan oleh dosen kebidanan Universitas Muhammadiyah Sumatera Barat yang bertujuan memberikan terapi kelompok terapeutik (TKT) yang berguna untuk meningkatkan stimulasi anak dalam belajar pada siswa di sanggar PCIA Malaysia. PKM ini

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Elmatsani, Huda M. "Pengembangan Aplikasi Pengukuran TKT Online." Jurnal Rekayasa Elektrika 13, no. 3 (2017): 185. http://dx.doi.org/10.17529/jre.v13i3.8584.

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Hill, D. A. "The TKT Course: CLIL Module." ELT Journal 66, no. 3 (2012): 416–17. http://dx.doi.org/10.1093/elt/ccs028.

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Vũ, Hữu Trung, Quốc Cường Lê, Văn Phú Nguyễn, Thị Vân Anh Nguyễn та Anh Tú Lê. "ĐẶC ĐIỂM VỊ TRÍ CÁC NHÁNH THẦN KINH TRÊN ĐÒN TRÊN ĐƯỜNG MỔ KẾT XƯƠNG 1/3 GIỮA XƯƠNG ĐÒN BẰNG NẸP VÍT". VietNam Military Medical Unisversity 49, № 6 (2024): 180–87. http://dx.doi.org/10.56535/jmpm.v49i6.831.

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Mục tiêu: Khảo sát vị trí của các nhánh thần kinh trên đòn (TKTĐ) trên tương quan với đường mổ trong phẫu thuật kết xương 1/3 giữa xương đòn bằng nẹp vít. Phương pháp nghiên cứu: Nghiên cứu tiến cứu, mô tả cắt ngang trên 26 bệnh nhân (BN) gãy kín 1/3 giữa xương đòn được phẫu thuật kết xương nẹp vít. Xác định chiều dài đường cơ sở là 100% tính từ khớp ức-đòn (0%) tới khớp cùng-đòn (100%), quá trình mổ bảo tồn các nhánh TKTĐ. Số lượng và khoảng cách từ mỗi nhánh đến khớp ức đòn được đo trên đường cơ sở và được ghi chép lại. Kết quả: Trên đường mổ kết xương 1/3 giữa xương đòn bằng nẹp vít thường

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Aleshin, Vasily A., Thilo Kaehne, Maria V. Maslova, Anastasia V. Graf, and Victoria I. Bunik. "Posttranslational Acylations of the Rat Brain Transketolase Discriminate the Enzyme Responses to Inhibitors of ThDP-Dependent Enzymes or Thiamine Transport." International Journal of Molecular Sciences 25, no. 2 (2024): 917. http://dx.doi.org/10.3390/ijms25020917.

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Transketolase (TKT) is an essential thiamine diphosphate (ThDP)-dependent enzyme of the non-oxidative branch of the pentose phosphate pathway, with the glucose-6P flux through the pathway regulated in various medically important conditions. Here, we characterize the brain TKT regulation by acylation in rats with perturbed thiamine-dependent metabolism, known to occur in neurodegenerative diseases. The perturbations are modeled by the administration of oxythiamine inhibiting ThDP-dependent enzymes in vivo or by reduced thiamine availability in the presence of metformin and amprolium, inhibiting

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Zhang, Zhichao, Qing Zhang, Shaohua Guan, and Hualin Shi. "Quantitative Connection between Cell Size and Growth Rate by Phospholipid Metabolism." Cells 9, no. 2 (2020): 391. http://dx.doi.org/10.3390/cells9020391.

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The processes involved in cell growth are extremely complicated even for a single cell organism such as Escherichia coli, while the relationship between growth rate and cell size is simple. We aimed to reveal the systematic link between them from the aspect of the genome-scale metabolic network. Since the growth rate reflects metabolic rates of bacteria and the cell size relates to phospholipid synthesis, a part of bacterial metabolic networks, we calculated the cell length from the cardiolipin synthesis rate, where the cardiolipin synthesis reaction is able to represent the phospholipid metab

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Yunita Astriani Hardayati and Mutianingsih. "STUDI KASUS: PENGARUH TERAPI KELOMPOK TEREAUPETIK DAN KUNJUNGAN RUMAH TERHADAP ASPEK PERKEMBANGAN ANAK USIA SEKOLAH." Jurnal Ners Nainawa 1, no. 1 (2023): 1–6. https://doi.org/10.62735/jnn.v1i1.2223.

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Usia sekolah dasar disebut masa intelektual atau masa keserasian sekolah dalam mencapai perkembangan industri. Tahapan perkembangan industri penting sepanjang rentang perkembangan. Tujuan oembuatan manuskrip ini adalah untuk menggambarkan penerapan terapi kelompok teraupetik (TKT) pada anak usia sekolah dengan mebandingkan kelompok anak yang diberikan TKT dan kunjungan rumah (5 klien) dan TKT saja (10 klien). Metode yang dipakai adalah studi kasus. . Pada klien yang diberikan TKT dan kunjungan rumah, aspek motorik lebih tinggi 0,08 kali, aspek kognitif dan bahasa lebih tinggi 0,04 kali, aspek

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Whitman, S. P., A. S. Ruppert, M. D. Radmacher, et al. "FLT3 D835/I836 mutations predict worse disease-free survival (DFS) in younger adults with cytogenetically normal acute myeloid leukemia (CN AML) without FLT3 internal tandem duplications (ITD): A Cancer and Leukemia Group B (CALGB) study." Journal of Clinical Oncology 25, no. 18_suppl (2007): 10532. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.10532.

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10532 Background: The adverse prognostic impact of FLT3 ITD is well-recognized in younger adults with CN AML, whereas the clinical relevance of D835/I836 mutations in the second tyrosine kinase domain of FLT3 (FLT3 TKD), that occur in 5%-14% of patients (pts), remains controversial. We evaluated the prognostic impact of FLT3 TKD, alone and with other prognostic markers, in 139 de novo CN AML adults, aged <60 years, without FLT3 ITD, and treated on similar CALGB protocols (9621 and 19808). Methods: FLT3 TKD was detected by RT-PCR/EcoRV digestion. Affymetrix U133 plus 2.0 gene expression prof

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Shadalli, Shadalli, Tiara Radini Alchandra Yasrial, Ulfa Amalia, and Wanda Luthfianita Sari. "PERKEMBANGAN PENGGUNAAN ALAT TES KEMAMPUAN DIFERENSIAL (TKD)." Flourishing Journal 2, no. 2 (2022): 130–36. http://dx.doi.org/10.17977/um070v2i22022p130-136.

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Abstract In the workplace and in the education sector, we are always focusing and connecting in terms of intelligence. Intelligence is a measure of how an individual behaves. It is measured by looking at on how interpersonal interactions, behavior, and individual achievements. The objective of this test is to measure a person's intelligence which is called an intelligence test. There are various types of intelligence tests and one of them is the Tes Kemampuan Diferensial (TKD). TKD is useful for measuring a person's differential ability or primary ability. This kind of test tool has been

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Tan, Xin, Elodie Ramond, Anne Jamet, et al. "Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection." Journal of Infectious Diseases 220, no. 12 (2019): 1967–76. http://dx.doi.org/10.1093/infdis/jiz404.

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Abstract Staphylococcus aureus is a leading cause of both acute and chronic infections in humans. The importance of the pentose phosphate pathway (PPP) during S. aureus infection is currently largely unexplored. In the current study, we focused on one key PPP enzyme, transketolase (TKT). We showed that inactivation of the unique gene encoding TKT activity in S. aureus USA300 (∆tkt) led to drastic metabolomic changes. Using time-lapse video imaging and mice infection, we observed a major defect of the ∆tkt strain compared with wild-type strain in early intracellular proliferation and in the abi

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Whitman, Susan P., Amy S. Ruppert, Michael D. Radmacher, et al. "FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications." Blood 111, no. 3 (2008): 1552–59. http://dx.doi.org/10.1182/blood-2007-08-107946.

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AbstractThe prognostic relevance of FLT3 D835/I836 mutations (FLT3-TKD) in cytogenetically normal acute myeloid leukemia (CN-AML) remains to be established. After excluding patients with FLT3 internal tandem duplications, we compared treatment outcome of 16 de novo CN-AML patients with FLT3-TKD with that of 123 patients with wild-type FLT3 (FLT3-WT), less than 60 years of age and similarly treated on Cancer and Leukemia Group B protocols. All FLT3-TKD+ patients and 85% of FLT3-WT patients achieved a complete remission (P = .13). Disease-free survival (DFS) of FLT3-TKD+ patients was worse than

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Hayati, Jurni, Tiara Pradani, and Dodi Tirtana. "The Moderation Role of Budget Ratcheting: The Relationship Between Fiscal Decentralization and Regional Spending." Equity: Jurnal Ekonomi 11, no. 2 (2024): 80–93. http://dx.doi.org/10.33019/equity.v11i2.191.

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This research aims to determine whether there is a relationship between fiscal decentralization and local government public spending in Indonesia. This research also aims to determine how budget ratcheting can strengthen the relationship between fiscal decentralization and local government regional spending in Indonesia. This research is a development of a which was modified by adding a Budget Ratcheting variable as moderation. The method used in this research is quantitative by analyzing data collected from provincial-level regional expenditure budget reports in Indonesia from 2018 to 2022. T

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Cendani, Dinda Sekar, Rahmat Mulyana, and Lukman Abdurrahman. "The, A Testing the Model of the Effect of IT Governance on Digital Transformation and Ministry of A Performance Using Structural Equation Modeling." JATISI (Jurnal Teknik Informatika dan Sistem Informasi) 10, no. 1 (2023): 381–94. http://dx.doi.org/10.35957/jatisi.v10i1.3211.

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Seiring dengan adanya disrupsi teknologi terkini, perubahan perilaku pemangku kepentingan menuju digital, juga pandemi Covid-19 telah mengarahkan berbagai organisasi untuk melakukan akselerasi transformasi digital (TD). Namun terjadi banyak kegagalan investasi TD yang diduga karena kurangnya tata kelola. Penelitian sebelumnya berhasil mengidentifikasi pengaruh TKTI tradisional dan agile/adaptif terhadap kesuksesan TD di sektor swasta. Oleh karena itu, pengujian model pengaruh TKTI terhadap TD dan kinerja organisasi(KO) pada sektor publik ini dilakukan. Penelitian ini mengambil studi kasus TD k

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