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Journal articles on the topic 'TLM'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 June 2025

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1

Isra, Nur, Syamsul Arifin Lias, and Asmita Ahmad. "KARAKTERISTIK UKURAN BUTIR DAN MINERAL LIAT TANAH PADA KEJADIAN LONGSOR (STUDI KASUS: SUB DAS JENEBERANG)." Jurnal Ecosolum 8, no. 2 (2019): 62. http://dx.doi.org/10.20956/ecosolum.v8i2.7874.

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Longsor dapat dipicu oleh karateristik tanah yang terbentuk pada suatu wilayah yang dipengaruhi oleh ukuran fraksi tanah, terutama fraksi tanah yang berukuran lebih halus, yaitu fraksi tanah dari mineral liat. Stabililitas wilayah sub DAS Jeneberang pasca kejadian runtuhnya kaldera Gunung Bawakaraeng, menyebabkan gangguan berupa longsoran disekitar wilayah sub DAS lainnya. Penelitian ini bertujuan untuk mengetahui karakteristik ukuran butir dan mineral liat tanah pada kejadian longsor di sub DAS hulu Jeneberang. Penelitian ini menggunakan metode deskriptif kuantitatif dengan mengidentifikasi ukuran butir menggunakan ayakan ASTM 48 dan mineral liat tanah menggunakan FTIR. Titik longsor (TL) ditentukan dari kejadian longsor yang terjadi dan titik pembanding (TPB) ditentukan dari topografi dan bahan induk yang sama dengan titik longsor. Topografi pada daerah penelitian berombak hingga sangat curam dengan rata-rata curah hujan delapan tahun terakhir 3484 mm/tahun. Hasil analisis Ukuran butiran pada semua titik longsor dan titik pembanding didominasi ukuran 0,5 mm dengan bentuk butiran subrounded pada TL1, TL3, TL5, TL6, TL7, TL8, TL 10, TPB3, TPB4 dan subangular pada TL2, TL4, TL9, TPB1, TPB2. Dari hasil analisis mineral liat bahwa mineral liat dominan pada TL1, TL2, TL3, TL10, TPB1, TPB2 adalah kaolinit. TL6, TL5 adalah haloisit. TL8, TL4 adalah montmorilonit. TL9, TL7, TPB3 adalah klorit dan TPB4 adalah nakrit. Longsor yng terjadi dipicu oleh mineral liat tersedia yaitu kaolinit, haloisit, montmorilonit, dan klorit, sementara ukuran butir tanah tidak memberikan banyak pengaruh pada kejadian longsor.Kata kunci: Sub DAS Jeneberang, Longsor, Ukuran Butir, Mineral Liat Tanah

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2

Charif, Mohamed, Soufiane El Adraoui, Mounirh Khalid, Asmaa Zugari, Mohamed I. Yaich, and Mohsine Khalladi. "Accuracy and CPU time of JE-TLM, PLRC-TLM and CRC-TLM methods for plasma medium." Optik 125, no. 13 (2014): 3138–41. http://dx.doi.org/10.1016/j.ijleo.2013.12.014.

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3

Colliver, Jerry A., Anna T. Cianciolo, Steven J. Verhulst, and Melinda J. Conlee. "TLM Anniversary Letter." Teaching and Learning in Medicine 25, no. 1 (2013): 1–2. http://dx.doi.org/10.1080/10401334.2013.758576.

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4

Portí, Jorge A., and Juan A. Morente. "TLM method and acoustics." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 14, no. 2 (2001): 171–83. http://dx.doi.org/10.1002/jnm.405.

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5

Krumpholz, M., B. Bader, and P. Russer. "On the theory of discrete TLM Green's functions in three-dimensional TLM." IEEE Transactions on Microwave Theory and Techniques 43, no. 7 (1995): 1472–83. http://dx.doi.org/10.1109/22.392904.

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6

Wang, Dengshun, Teng Zou, Tong Gao, et al. "Diagnosis and prognosis of different methods of tongue base mucosectomy for occult head and neck cancer: A systematic review and meta-analysis." Medicine 103, no. 46 (2024): e40250. http://dx.doi.org/10.1097/md.0000000000040250.

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Background: Trans-oral robotic surgery (TORS) and trans-oral laser microsurgery (TLM) have been increasingly employed for the diagnosis and identification of primary occult cancers in the head and neck region. This systematic review and meta-analysis aimed to evaluate the application and effectiveness of tonsillectomy with TORS and TLM in detecting these cancers. Methods: We searched PubMed, EMBASE, and the Cochrane Library for eligible studies using TORS or TLM in identifying the unknown primary sites of occult head and neck cancer, published from inception to September 2023. Two investigators independently screened articles based on inclusion and exclusion criteria. Results: From 2282 articles identified, 20 individual studies meeting the inclusion criteria were included in this meta-analysis. Primary tumors were identified by TORS/TLM in 65% (364/561) of patients. The initial identification rates of lingual tonsillectomy (n = 219) and palatine tonsillectomy (n = 83) were 39% and 15%, respectively. The identification rates of primary sites for trans-oral surgical techniques were 60.7% (95% CI, 49.4–72%) for TORS and 75.7% (95% CI, 60.7–90.7%) for TLM. Seventy-nine point six percent (467/587) of the tumors were associated with human papilloma virus (HPV). The detection rate of HPV+ tumors was 79% (173/220) and the detection rate of HPV− tumors was 10% (5/52). The most common complication was nasogastric/gastrostomy, accounting for 6% (29/481). The length of hospital stay reported varied from 1 to more than 7 days. Conclusion: This is a latest systematic review of the detection rates of head and neck squamous cell carcinoma of unknown primary sites by tongue base mucosectomy (TBM) via TORS and TBM via TLM. This study confirmed that TBM via TLM performed better than TBM–TORS in the detection rate of the primary. In particular, TBM via TLM showed significant advantages in detecting primary lesions in HPV-positive head and neck squamous cell carcinoma of unknown primary patients.

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7

LeMaguer, S., A. Peden, D. Bourreau, and M. M. Ney. "Split-Step TLM (SS TLM)—A New Scheme for Accelerating Electromagnetic-Field Simulation." IEEE Transactions on Microwave Theory and Techniques 52, no. 4 (2004): 1182–90. http://dx.doi.org/10.1109/tmtt.2004.825729.

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8

Le Maguer, S., and M. M. Ney. "Alternating TLM symmetrical condensed node." Electronics Letters 38, no. 15 (2002): 779. http://dx.doi.org/10.1049/el:20020561.

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9

Duffy, A. P., J. L. Herring, T. M. Benson, and C. Christopoulos. "Improved wire modelling in TLM." IEEE Transactions on Microwave Theory and Techniques 42, no. 10 (1994): 1978–83. http://dx.doi.org/10.1109/22.320783.

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10

de Cogan, D., and A. Soulos. "INVERSE THERMAL MODELING USING TLM." Numerical Heat Transfer, Part B: Fundamentals 29, no. 1 (1996): 125–35. http://dx.doi.org/10.1080/10407799608914978.

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11

Parsons, P. J., S. R. Jaques, S. H. Pulko, and F. A. Rabhi. "TLM modeling using distributed computing." IEEE Microwave and Guided Wave Letters 6, no. 3 (1996): 141–42. http://dx.doi.org/10.1109/75.481093.

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12

Dawson, J. F. "Improved magnetic loss for TLM." Electronics Letters 29, no. 5 (1993): 467. http://dx.doi.org/10.1049/el:19930312.

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13

Hui, S. Y. R., K. K. Fung, and C. Christopoulos. "TLM stub-link conversion technique." Electronics Letters 29, no. 11 (1993): 998–99. http://dx.doi.org/10.1049/el:19930665.

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14

Mlakar, J. "Lumped circuit symmetrical TLM node." Electronics Letters 28, no. 5 (1992): 497. http://dx.doi.org/10.1049/el:19920313.

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15

O'Connor, W. J. "TLM coefficients with distributed losses." Electronics Letters 35, no. 6 (1999): 460. http://dx.doi.org/10.1049/el:19990332.

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16

Wong, Chi Chung, and Wing Sun Wong. "Multigrid TLM for diffusion problems." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 2, no. 2 (1989): 103–11. http://dx.doi.org/10.1002/jnm.1660020206.

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17

De Cogan, Donard. "Thermal radiative boundaries in TLM." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 6, no. 2 (1993): 165–66. http://dx.doi.org/10.1002/jnm.1660060209.

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18

Krumpholz, M., and P. Russer. "Two-dimensional FDTD and TLM." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 7, no. 2 (1994): 141–53. http://dx.doi.org/10.1002/jnm.1660070207.

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19

Matsumoto, Shinichi, Theodore H. Rigley, Sabrina A. Qualley, Yoshikazu Kuroda, Jo Anna Reems, and R. Brian Stevens. "Efficacy of the Oxygen-Charged Static Two-Layer Method for Short-Term Pancreas Preservation and Islet Isolation from Nonhuman Primate and Human Pancreata." Cell Transplantation 11, no. 8 (2002): 769–77. http://dx.doi.org/10.3727/000000002783985332.

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Previous reports indicate that the two-layer method (TLM) of human pancreas preservation is superior to University of Wisconsin solution (UW) when pancreata are preserved for extended periods (i.e., >24 h) prior to islet isolation. In this study, the efficacy of using the TLM for preserving pancreata for short periods (i.e., <13 h) was evaluated using both nonhuman primate and human pancreata preserved with a TLM kit precharged with oxygen. An oxygen precharged TLM (static TLM) was established and compared with the original TLM with continuous oxygen supply. For the static TLM, the perfluorochemical was fully oxygenated and the oxygen supply removed prior to pancreas preservation. In the primate model, pancreata were preserved by the static TLM, the original TLM, and UW for 5 h prior to islet isolation. In the human model, pancreata were preserved with the static TLM or the original TLM or UW for 4–13 h. Both primate and human pancreata were processed by intraductal collagenase injection and digestion followed by continuous density gradient purification to isolate islets. Islets were assessed for islet yield, purity, viability, and in vitro functionality. In the primate model, islet yield, viability, and in vitro functionality were significantly improved by both the static TLM and the original TLM with similar results. Postculture islet yields were 23,877 ± 3619 IE/g in the static TLM, 21,895 ± 3742 IE/g in the original TLM, and 6773 ± 735 IE/g in UW. In the human model, both the static TLM and the original TLM significantly increased islet yield compared with UW with postculture islet yields of 2659 ± 549 IE/g in the static TLM, 2244 ± 557 IE/g in the original TLM, and 1293 ± 451 IE/g in UW. Nonhuman primate and human pancreata stored in the static TLM, immediately upon procurement, yield isolated islets of a substantially higher quantity than when pancreata are stored in UW. Thus, the use of the static TLM should replace the use of UW for storage of pancreata during transport prior to islet isolation.

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20

Zhang Jingjun and Fu Junmei. "Higher order mode cutoff frequencies in TEM cells calculated with TLM method." IEEE Transactions on Electromagnetic Compatibility 30, no. 4 (1988): 563–67. http://dx.doi.org/10.1109/15.8771.

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21

Tsukahara, S. "Atomic Structure-Sensitive Magnetic Domain Structures of Thin Films." Proceedings, annual meeting, Electron Microscopy Society of America 43 (August 1985): 206–9. http://dx.doi.org/10.1017/s0424820100117960.

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Transmission electron microscopy, TEM, that can serve for observation of both atomic and magnetic structures is useful to investigate structure sensitive magnetic properties. It is most effective when it is applied to thin films for which direct interpretation of the results is possible without considering additional effects through specimen handling for TEM use and modification of dimension dependent magnetic properties.Transmission Lorentz microscopy, TLM, to observe magnetic domains has been known for a quarter century. Among TLM modes the defocused mode has been most popular due to its simple way of operation. Recent development of TEM made it possible that an average instrument commercially available could be easily operated at any TLM modes to produce high quality images. This paper mainly utilizes the Foucault mode to investigate domain walls and magnetization ripples as the finest details of domain structure.

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22

Sooai, Eldalivia Y., Paulina Y. Amtiran, and Rolland E. Fanggidae. "PERSEPSI NASABAH TERHADAP PELAYANAN FRONTLINER (STUDI KASUS PADA BPR TLM)." JAF- Journal of Accounting and Finance 2, no. 2 (2019): 1. http://dx.doi.org/10.25124/jaf.v2i2.2142.

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The objective of the study about “Persepsi Nasabah Terhadap Pelayanan Frontliner (Studi Kasus Pada BPR TLM)” is to determine the effect of custumer perceptions based on attitude, motivation, and past experience on frontline service in BPR TLM. This study is using quantitative descriptive approach. This study is using primary data in the form of questionnaire distributed to 100 customers who made transaction at BPR TLM and also using accidental sampling method. The result of the questionnaire regarding frontliner services wer anayzed by multiple linear regression. The result shows that customer perceptions based on attitude, motivation and past experience have significant possitive effect on frontliner services on BPR TLM. This is caused fronliner services is in line with customer’s expectations, which is shown by officer fronliner attitude who are friendly and can serve customer’s needs well. The comfort waitng room and fashion style of the officer make the customers feel that frontliner services in BPR TLM is good.

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23

El ouardy, El hadi, and Hanan El Faylali. "The New ADE-TLM Algorithm for Modeling Debye Medium." International journal of electrical and computer engineering systems 14, no. 10 (2023): 1125–31. http://dx.doi.org/10.32985/ijeces.14.10.5.

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In this paper, we present a novel approach to simulating the interaction between electromagnetic waves and a Debye medium utilizing a Transmission Line Matrix (TLM) algorithm with the symmetrical condensed node (SCN-TLM) technique. The proposed method utilizes the polarization current within the media and incorporates the auxiliary differential equation (ADE) technique to handle scattering following the conventional discretization process. The averaged approximation is employed to utilize the polarization current density J and the electric voltage. By reducing the number of operations required per iteration, the New ADE- TLM method has successfully decreased the computational time compared to time convolution techniques. Despite this reduction in computational time, the New ADE-TLM method maintains a numerical accuracy that is comparable to that of time convolution techniques. The efficiency and precision of this approach are confirmed by the agreement between the results obtained and those predicted by the analytic model.

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24

Doncov, N., A. J. Wlodarczyk, R. Scaramuzza, and V. Trenkic. "Compact TLM model for air-vents." Electronics Letters 38, no. 16 (2002): 887. http://dx.doi.org/10.1049/el:20020614.

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25

Seyyed-Kalantari, Laleh, Mohamed H. Bakr, and Natalia K. Nikolova. "Sensitivity Analysis of Ferrites With TLM." IEEE Microwave and Wireless Components Letters 27, no. 12 (2017): 1044–46. http://dx.doi.org/10.1109/lmwc.2017.2750408.

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26

Le, Hoang M., Daniel Grosse, and Rolf Drechsler. "Automatic TLM Fault Localization for SystemC." IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems 31, no. 8 (2012): 1249–62. http://dx.doi.org/10.1109/tcad.2012.2188800.

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27

Krumpholz, M., and P. Russer. "A field theoretical derivation of TLM." IEEE Transactions on Microwave Theory and Techniques 42, no. 9 (1994): 1660–68. http://dx.doi.org/10.1109/22.310559.

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28

Righi, M., W. J. R. Hoefer, M. Mongiardo, and R. Sorrentino. "Efficient TLM diakoptics for separable structures." IEEE Transactions on Microwave Theory and Techniques 43, no. 4 (1995): 854–59. http://dx.doi.org/10.1109/22.375234.

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29

Baier, S. M., M. S. Shur, K. Lee, N. C. Cirillo, and S. A. Hanka. "FET Characterization using gated-TLM structure." IEEE Transactions on Electron Devices 32, no. 12 (1985): 2824–29. http://dx.doi.org/10.1109/t-ed.1985.22422.

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30

Mahani, Negin. "TLM request response channel in SystemAda." ACM SIGAda Ada Letters 32, no. 1 (2012): 13–18. http://dx.doi.org/10.1145/2380624.2380627.

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31

Attalhaoui, Abdellah, Hamid Bezzout, Mohamed Habibi, and Hanan El Faylali. "New TLM formulations for Debye medium." Optik 207 (April 2020): 164436. http://dx.doi.org/10.1016/j.ijleo.2020.164436.

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32

Ait-sadi, R., and P. Naylor. "Validity of TLM modelling of diffusion." Electronics Letters 27, no. 24 (1991): 2216. http://dx.doi.org/10.1049/el:19911371.

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33

Wlodarczyk, A. J. "Representation of symmetrical condensed TLM node." Electronics Letters 28, no. 18 (1992): 1686. http://dx.doi.org/10.1049/el:19921072.

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34

Morente, J. A., J. A. Portí, G. Giménez, and A. Gallego. "Loaded-wire node for TLM method." Electronics Letters 29, no. 2 (1993): 182. http://dx.doi.org/10.1049/el:19930123.

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35

Flint, J. A., S. C. Pomeroy, and D. D. Ward. "Compact partial Huygen's surface for TLM." Electronics Letters 35, no. 2 (1999): 132. http://dx.doi.org/10.1049/el:19990112.

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36

Chamorro-Posada, P. "TLM Analysis of Multimode Interference Devices." Fiber and Integrated Optics 25, no. 1 (2006): 1–10. http://dx.doi.org/10.1080/01468030500332192.

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37

Gui, Xiang, and Donard de Cogan. "Boundary conditions in TLM diffusion modelling." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 19, no. 1 (2005): 69–82. http://dx.doi.org/10.1002/jnm.599.

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38

Biwojno, Konrad, Chris Smartt, Phillip Sewell, Yafang Liu, and Christos Christopoulos. "TLM node with arbitrary embedded objects." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 20, no. 1-2 (2006): 65–73. http://dx.doi.org/10.1002/jnm.631.

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39

Barba, I., A. C. L. Cabeceira, M. Panizo, and J. Represa. "Modelling dispersive dielectrics in TLM method." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 14, no. 1 (2001): 15–30. http://dx.doi.org/10.1002/1099-1204(200101/02)14:1<15::aid-jnm393>3.0.co;2-j.

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40

Tan, C. C., and V. F. Fusco. "TLM modelling using an SIMD computer." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 6, no. 4 (1993): 299–304. http://dx.doi.org/10.1002/jnm.1660060406.

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41

Hurst, A. I., and S. H. Pulko. "TLM treatments of changes of phase." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 7, no. 3 (1994): 201–7. http://dx.doi.org/10.1002/jnm.1660070307.

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42

Wilkinson, A. J., S. H. Pulko, and A. Saidane. "Discretization effects in TLM diffusion models." International Journal of Numerical Modelling: Electronic Networks, Devices and Fields 13, no. 1 (2000): 59–74. http://dx.doi.org/10.1002/(sici)1099-1204(200001/02)13:1<59::aid-jnm382>3.0.co;2-9.

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43

Elsayed, Mahmoud M. A., Moustafa O. Aboelez, Bakheet E. M. Elsadek, et al. "Tolmetin Sodium Fast Dissolving Tablets for Rheumatoid Arthritis Treatment: Preparation and Optimization Using Box-Behnken Design and Response Surface Methodology." Pharmaceutics 14, no. 4 (2022): 880. http://dx.doi.org/10.3390/pharmaceutics14040880.

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Tolmetin sodium (TLM) is a non-steroidal anti-inflammatory drug (NSAIDs). TLM is used to treat inflammation, skeletal muscle injuries, and discomfort associated with bone disorders. Because of the delayed absorption from the gastro intestinal tract (GIT), the currently available TLM dosage forms have a rather protracted start to the effect, according to pharmacokinetic studies. The aim of this study was to create a combination for TLM fast dissolving tablets (TLM-FDT) that would boost the drug’s bioavailability by increasing pre-gastric absorption. The TLM-FDTs were developed using a Box-Behnken experimental design with varied doses of crospovidone (CP), croscarmellose sodium (CCS) as super-disintegrants, and camphor as a sublimating agent. In addition, the current study used response surface approach to explore the influence of various formulation and process factors on tablet qualities in order to verify an optimized TLM-FDTs formulation. The optimized TLM-FDTs formula was subsequently evaluated for its in vivo anti-inflammatory activity. TLM-FDTs have good friability, disintegration time, drug release, and wetting time, as well as fast disintegration and dissolution behavior. Significant increase in drug bioavailability and reliable anti-inflammatory efficacy were also observed, as evidenced by considerable reductions in paw thickness in rats following carrageenan-induced rat paw edema. For optimizing and analyzing the effect of super-disintegrants and sublimating agents in the TLM-FDTs formula, the three-factor, three-level full factorial design is a suitable tool. TLM-FDTs are a possible drug delivery system for enhancing TLM bioavailability and could be used to treat rheumatoid arthritis.

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44

Noguchi, Hirofumi, Marlon F. Levy, Naoya Kobayashi, and Shinichi Matsumoto. "Pancreas Preservation by the Two-Layer Method: Does it Have a Beneficial Effect Compared with Simple Preservation in University of Wisconsin Solution?" Cell Transplantation 18, no. 5-6 (2009): 497–504. http://dx.doi.org/10.1177/096368970901805-603.

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A large number of reports have shown that the two-layer method (TLM), which employs oxygenated perfluorochemical (PFC) and University of Wisconsin (UW) solution, is superior to simple cold storage in UW in islet transplantation. However, two recent large-scale studies showed no beneficial effect of TLM compared with UW storage in human islet transplantation. We reevaluated the effect of TLM by following three groups: group 1: UW simple storage; group 2: TLM performed by multiorgan procurement teams (not specialists of islet isolation); and group 3: TLM performed by specialists of islet isolation (Noguchi and Matsumoto). There were no significant differences between groups 1 and 2, whereas islet yields were significantly higher in group 3 compared with either group 1 or 2. Our data suggest that exact, complete performance of TLM could improve the outcome of islet isolation and transplantation. In this review, we describe the mechanisms of the TLM, the procedure of preoxygenated TLM, and the several possibilities for the reasons of the discrepancy.

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45

Thomas, F., C. Liautard, F. Cézilly, and F. Renaud. "A finite time horizon influences sequential mate choice in male Gammarus aequicauda (Amphipoda)." Canadian Journal of Zoology 76, no. 3 (1998): 400–404. http://dx.doi.org/10.1139/z97-211.

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Although size-assortative pairing has been extensively studied in amphipods, the influence of time left to moult (TLM) on pairing decisions of male gammarids remains largely unexplored. Given that moulting males cannot guard their mates, we investigated the influence of TLM for males on size-assortative mating in the gammarid Gammarus aequicauda (Crustacea, Amphipoda). There was a significant relationship between TLM and size in males. Unpaired males were closer to their moult than paired ones. Among pairs, there was a significant positive relationship between male and female sizes and between male and female TLM values. However, males closer to the moult were paired with females of more varying sizes than were other males, suggesting that a decrease in TLM reduces choosiness in males. Although there was a significant relationship between TLM and size in males, size-assortative mating was independent of male TLM.

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46

Jackowski, Suzanne, Yong-Mei Zhang, Allen C. Price, Stephen W. White та Charles O. Rock. "A Missense Mutation in the fabB (β-Ketoacyl-Acyl Carrier Protein Synthase I) Gene Confers Thiolactomycin Resistance to Escherichia coli". Antimicrobial Agents and Chemotherapy 46, № 5 (2002): 1246–52. http://dx.doi.org/10.1128/aac.46.5.1246-1252.2002.

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ABSTRACT Thiolactomycin (TLM) is an antibiotic that inhibits bacterial type II fatty acid synthesis at the condensing enzyme step, and β-ketoacyl-acyl carrier protein synthase I (FabB) is the relevant target in Escherichia coli. TLM resistance is associated with the upregulation of efflux pumps. Therefore, a tolC knockout mutant (strain ANS1) was constructed to eliminate the contribution of type I secretion systems to TLM resistance. Six independent TLM-resistant clones of strain ANS1 were isolated, and all possessed the same missense mutation in the fabB gene (T1168G) that directed the expression of a mutant protein, FabB(F390V). FabB(F390V) was resistant to TLM in vitro. Leucine is the only other amino acid found at position 390 in nature, and the Staphylococcus aureus FabF protein, which contains this substitution, was sensitive to TLM. Structural modeling predicted that the CG2 methyl group of the valine side chain interfered with the positioning of the C11 methyl on the isoprenoid side chain of TLM in the binary complex, whereas the absence of a bulky methyl group on the leucine side chain permitted TLM binding. These data illustrate that missense mutations that introduce valine at position 390 confer TLM resistance while maintaining the vital catalytic properties of FabB.

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47

Ivanova, D. A., N. V. Litvinova, E. I. Yurovskaya, E. P. Kubrakova, and Yu Yu Mitrofanova. "Therapeutic drug monitoring in the treatment of tuberculosis patients." Tuberculosis and socially significant diseases 12, no. 4 (2025): 54–65. https://doi.org/10.54921/2413-0346-2024-12-4-54-65.

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Therapeutic drug monitoring (TDM) is one of the most promising technologies for personalized tuberculosis therapy, which can significantly improve the efficacy and safety of treatment in the most complex categories of patients. The applied goal of TDM is to optimize doses of TB drugs based on the control of their serum concentrations during treatment.The review considers the basic principles, definitions and parameters of TLM, current indications for testing, methods of data collection, analysis and interpretation from the perspective of a practicing phthisiatric physician; analysis of the evidence base is presented. The target populations for implementation of TLM are patients with HIV infection, diabetes mellitus, other severe multicomorbid pathology; pediatric and elderly patients, with delayed response to treatment and high risk of severe adverse reactions.For effective implementation of TLM it is necessary to conduct controlled studies to assess its clinical and economic results, to develop methods to increase the availability of this technology for the maximum number of TB institutions.

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Fichtner, N., and P. Russer. "An accelerated hybrid TLM-IE method for the investigation of shielding effectiveness." Advances in Radio Science 8 (September 30, 2010): 13–18. http://dx.doi.org/10.5194/ars-8-13-2010.

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Abstract. A hybrid numerical technique combining time-domain integral equations (TD-IE) with the transmission line matrix (TLM) method is presented for the efficient modeling of transient wave phenomena. This hybrid method allows the full-wave modeling of circuits in the time-domain as well as the electromagnetic coupling of remote TLM subdomains using integral equations (IE). By using the integral equations the space between the TLM subdomains is not discretized and consequently doesn't contribute to the computational effort. The cost for the evaluation of the time-domain integral equations (TD-IE) is further reduced using a suitable plane-wave representation of the source terms. The hybrid TD-IE/TLM method is applied in the computation of the shielding effectiveness (SE) of metallic enclosures.

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Kostic, Milos, Nebojsa Doncov, Biljana Stosic, and Bratislav Milovanovic. "Digital filter-based 1D TLM model of dispersive anisotropic conductivity panel." Serbian Journal of Electrical Engineering 13, no. 1 (2016): 1–8. http://dx.doi.org/10.2298/sjee1601001k.

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One-dimensional (1D) Transmission Line Matrix (TLM) method with Z-transforms, is applied in the paper to allow for an efficient time-domain simulation of thin anisotropic conductive panel of dispersive behavior. It uses a digital filter model to incorporate the scattering coefficients of the panel at two TLM cells interface in order to avoid a fine meshing of panel thickness. Model validation is done for a panel made of carbon-fibre material whose electric conductivity is anisotropic and assumed to be frequency dependent according to the Drude model. Fine TLM mesh results are used to verify the model accuracy.

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Huang, Emily Y., Henry H. Joo, Sarek A. Shen, Matthew R. Naunheim, Ved Tanavde, and Lee M. Akst. "Trends in Treatment Choice for Early Glottic Cancer." Journal of Clinical Medicine 14, no. 9 (2025): 3095. https://doi.org/10.3390/jcm14093095.

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Background/Objective: Systemic investigation into treatment for early-stage glottic cancer (EGC) has demonstrated similar functional and oncologic outcomes between transoral laser microsurgery (TLM) and external beam radiotherapy (XRT). In this study, we aim to identify longitudinal trends in treatment decisions and patient demographics. Methods: This is a retrospective longitudinal study on all cases of T1-2N0M0 glottic carcinoma queried from the NCDB between 2004 and 2017. The ratio of TLM to XRT (TLM/XRT) performed per year was calculated and further stratified by insurance status, education, income, and treatment facility location. Univariable and multivariable linear regressions were used to assess the trend of TLM/XRT over time and evaluate the effect of demographic characteristics on the TLM/XRT ratio. Results: A total of 38,428 EGC patients were analyzed: 2169 (5.6%) received TLM; 36,259 (94.4%) underwent XRT. The overall ratio of TLM/XRT increased over time from 0.04 in 2004 to 0.08 in 2017. Significant increases were observed in the higher-income quartiles (Q4: p < 0.001, Q3: p = 0.02, Q2 < 0.001) and among patients with private (p < 0.02) or public (p = 0.003) insurance. TLM/XRT rose significantly over time in the highest (Q4), third (Q3), and lowest (Q1) education quartiles but not in the second (Q2). Regionally, increases were observed in the Northeast (p < 0.001) and West (p = 0.008), with no significant change in the South or Midwest. By T stage, only T1 tumors showed a significant increase in TLM/XRT over time (p < 0.001). Conclusions: While the majority of patients receive XRT as the initial treatment for EGC, the proportion of TLM has been slowly increasing over time. Patient insurance status, education, income, facility geography, and T stage are correlated with increasing use of TLM.

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