Log in

Relevant bibliographies by topics / TNFRSF10A / Journal articles

To see the other types of publications on this topic, follow the link: TNFRSF10A.

Journal articles on the topic 'TNFRSF10A'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'TNFRSF10A.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Teocchi, Marcelo Ananias, and Lília D’Souza-Li. "Apoptosis through Death Receptors in Temporal Lobe Epilepsy-Associated Hippocampal Sclerosis." Mediators of Inflammation 2016 (2016): 1–12. http://dx.doi.org/10.1155/2016/8290562.

Full text

Abstract:

Seizure models have demonstrated that neuroinflammation and neurodegeneration are preponderant characteristics of epilepsy. Considering the lack of clinical studies, our aim is to investigate the extrinsic pathway of apoptosis in pharmacoresistant temporal lobe epilepsy (TLE) associated with hippocampal sclerosis (HS) patients, TLE(HS). By a specific death receptor-mediated apoptosis array plate, 31 upregulated targets were revealed in the sclerotic hippocampus from TLE(HS) patients. Amongst them are the encoding genes for ligands (FASLG,TNF,andTNFSF10) and death receptors (FAS,TNFRSF1A,TNFRSF

APA, Harvard, Vancouver, ISO, and other styles

2

Carnicer, Maria J., Adriana Lasa, Elena Serrano, et al. "Epigenetic-Based Treatment Induces Apoptosis in Leukemic Cell Lines." Blood 108, no. 11 (2006): 4382. http://dx.doi.org/10.1182/blood.v108.11.4382.4382.

Full text

Abstract:

Abstract Pharmacological treatment of cancer cells with demethylating agents and histone deacetylase inhibitors synergistically reactivates the transcription of previously silenced genes. The aim of this study was to investigate the antileukemic properties of a DNA mehtyltransferase inhibitor 5-aza-2′-deoxycytidine (5-Aza-dC),an histone deacetylase inhibitor Trichostatin A (TSA) and trans-retinoc acid (ATRA), alone or in combination. The effects of these drugs on apoptosis, cell cycle progression, cell-survival pathways and restoration of proliferation-associated genes silenced by aberrant epi

APA, Harvard, Vancouver, ISO, and other styles

3

Seirafian, Sepehr, Virginie Prod’homme, Daniel Sugrue, et al. "Human cytomegalovirus suppresses Fas expression and function." Journal of General Virology 95, no. 4 (2014): 933–39. http://dx.doi.org/10.1099/vir.0.058313-0.

Full text

Abstract:

Human cytomegalovirus (HCMV) is known to evade extrinsic pro-apoptotic pathways not only by downregulating cell surface expression of the death receptors TNFR1, TRAIL receptor 1 (TNFRSF10A) and TRAIL receptor 2 (TNFRSF10B), but also by impeding downstream signalling events. Fas (CD95/APO-1/TNFRSF6) also plays a prominent role in apoptotic clearance of virus-infected cells, so its fate in HCMV-infected cells needs to be addressed. Here, we show that cell surface expression of Fas was suppressed in HCMV-infected fibroblasts from 24 h onwards through the late phase of productive infection, and wa

APA, Harvard, Vancouver, ISO, and other styles

4

Lee, Kuei-Fang, Julia Tzu-Ya Weng, Paul Wei-Che Hsu, et al. "Gene Expression Profiling of Biological Pathway Alterations by Radiation Exposure." BioMed Research International 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/834087.

Full text

Abstract:

Though damage caused by radiation has been the focus of rigorous research, the mechanisms through which radiation exerts harmful effects on cells are complex and not well-understood. In particular, the influence of low dose radiation exposure on the regulation of genes and pathways remains unclear. In an attempt to investigate the molecular alterations induced by varying doses of radiation, a genome-wide expression analysis was conducted. Peripheral blood mononuclear cells were collected from five participants and each sample was subjected to 0.5 Gy, 1 Gy, 2.5 Gy, and 5 Gy of cobalt 60 radiati

APA, Harvard, Vancouver, ISO, and other styles

5

Li, Tianliang, Ling Su, Yuanjiu Lei, Xianfang Liu, Yajing Zhang, and Xiangguo Liu. "DDIT3 and KAT2A Proteins Regulate TNFRSF10A and TNFRSF10B Expression in Endoplasmic Reticulum Stress-mediated Apoptosis in Human Lung Cancer Cells." Journal of Biological Chemistry 290, no. 17 (2015): 11108–18. http://dx.doi.org/10.1074/jbc.m115.645333.

Full text

APA, Harvard, Vancouver, ISO, and other styles

6

Xiao, Zheng, Kechao Nie, Tong Han, et al. "Development and Validation of a TNF Family-Based Signature for Predicting Prognosis, Tumor Immune Characteristics, and Immunotherapy Response in Colorectal Cancer Patients." Journal of Immunology Research 2021 (September 9, 2021): 1–16. http://dx.doi.org/10.1155/2021/6439975.

Full text

Abstract:

In this study, a comprehensive analysis of TNF family members in colorectal cancer (CRC) was conducted and a TNF family-based signature (TFS) was generated to predict prognosis and immunotherapy response. Using the expression data of 516 CRC patients from The Cancer Genome Atlas (TCGA) database, TNF family members were screened to construct a TFS by using the univariate Cox proportional hazards regression and the least absolute shrinkage and selection operator- (LASSO-) Cox proportional hazards regression method. The TFS was then validated in a meta-Gene Expression Omnibus (GEO) cohort ( n = 1

APA, Harvard, Vancouver, ISO, and other styles

7

Rinaldi, Andrea, Ekaterina Chigrinova, Ivo Kwee, et al. "SNP-Arrays Provide New Insights Into the Pathogenesis of Richter Syndrome (RS)." Blood 118, no. 21 (2011): 263. http://dx.doi.org/10.1182/blood.v118.21.263.263.

Full text

Abstract:

Abstract Abstract 263 RS represents the development of a diffuse large B-cell lymphoma (DLBCL) in the context of chronic lymphocytic leukemia (CLL). The pathogenesis of RS is still largely unknown. Analysis of RS has been often focused on the study of lesions previously identified in de novo DLBCL. However, we have previously shown that RS lacks many of the typical genetic lesions shown in DLBCL (Rossi et al, Blood 2011). Here, we have applied an unbiased, genome-wide approach, searching for DNA copy number alterations in a large series of RS, comparing them with de novo DLBCL, CLL-phase of RS

APA, Harvard, Vancouver, ISO, and other styles

8

Kohlhammer, Holger, Carsten Schwaenen, Swen Wessendorf, et al. "Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions." Blood 104, no. 3 (2004): 795–801. http://dx.doi.org/10.1182/blood-2003-12-4175.

Full text

Abstract:

AbstractTumor samples of 53 patients with t(11;14)-positive mantle cell lymphomas (MCLs) were analyzed by matrix-based comparative genomic hybridization (matrix-CGH) using a dedicated DNA array. In 49 cases, genomic aberrations were identified. In comparison to chromosomal CGH, a 50% higher number of aberrations was found and the high specificity of matrix-CGH was demonstrated by fluorescence in situ hybridization (FISH) analyses. The 11q gains and 13q34 deletions, which have not been described as frequent genomic aberrations in MCL, were identified by matrix-CGH in 15 and 26 cases, respective

APA, Harvard, Vancouver, ISO, and other styles

9

Liu, Yang, Yong Zhang, Phong Quang, et al. "Deregulation of TNFRSF18 (GITR) Through Promoter CpG Island Methylation Induces Tumor Proliferation in Multiple Myeloma." Blood 118, no. 21 (2011): 2424. http://dx.doi.org/10.1182/blood.v118.21.2424.2424.

Full text

Abstract:

Abstract Abstract 2424 Introduction Tumor necrosis factor receptor super families (TNFRSFs) play an important role in activation of lymphocyte and cell apoptosis. However the function of TNFRSFs in multiple myeloma (MM) remains unknown. Loss of function mutation of Fas antigen (TNFRSF6) was identified in MM cells, thus suggesting the possible role of TNFRSFs in regulating MM pathogenesis. We therefore investigated the epigenetic mechanisms that may mediate inactivation of TNFRSFs and its functional role in MM. Methods Dchip software was utilized for analyzing gene expression dataset. DNA was e

APA, Harvard, Vancouver, ISO, and other styles

10

Dufva, Olli, Khalid Saeed, Sara Gandolfi, et al. "CRISPR Screens Identify Mechanisms of Natural Killer Cell Evasion across Blood Cancers." Blood 134, Supplement_1 (2019): 3597. http://dx.doi.org/10.1182/blood-2019-129837.

Full text

Abstract:

Natural killer (NK) cells have been suggested to control progression and relapse in several hematological malignancies. Enhancing NK cell reactivity represents an attractive approach to improve treatment responses. However, mechanisms enabling evasion of hematologic cancer cells from NK cells are incompletely understood. To identify cancer cell-intrinsic factors enabling resistance to NK cell cytotoxicity, we conducted genome-wide CRISPR screens in a range of hematological malignancies. Cas9-expressing cancer cells from diverse hematological malignancies, including acute and chronic myeloid le

APA, Harvard, Vancouver, ISO, and other styles

11

Naser, Amna, Ahmad K. Odeh, Robert C. Sharp, Ahmad Qasem, Shazia Beg, and Saleh A. Naser. "Polymorphisms in TNF Receptor Superfamily 1B (TNFRSF1B:rs3397) are Linked to Mycobacterium avium paratuberculosis Infection and Osteoporosis in Rheumatoid Arthritis." Microorganisms 7, no. 12 (2019): 646. http://dx.doi.org/10.3390/microorganisms7120646.

Full text

Abstract:

We previously discovered that single nucleotide polymorphisms (SNPs) in PTPN2/22 (T-cell negative-regulators) occur in 78% of rheumatoid arthritis (RA), along with Mycobacterium avium paratuberculosis (MAP) infection in 33% of patients. In Crohn’s disease, we reported that SNPs in TNFα and receptors (TNFRSF1A/TNFRSF1B) benefited intracellular MAP-survival, increased infection, and elevated inflammatory response mimicking the poor response to anti-TNFα treatment in some patients. Here, we studied the frequency and effects of SNPs in TNFα/TNFRSF1A/TNFRSF1B in RA including gene expression, MAP in

APA, Harvard, Vancouver, ISO, and other styles

12

Pucino, V., J. D. Turner, F. Kollert, et al. "SAT0229 PROTEOMIC ANALYSIS REVEALS ASSOCIATION BETWEEN IMMUNE-METABOLIC BIOMARKERS AND CLINICAL SYMPTOMS IN SICCA PATIENTS." Annals of the Rheumatic Diseases 79, Suppl 1 (2020): 1057.1–1057. http://dx.doi.org/10.1136/annrheumdis-2020-eular.2900.

Full text

Abstract:

Background:Sjögren’s syndrome (SS) is a systemic autoimmune disease whose main characteristic is involvement of the exocrine glandular system. Thus, its most common clinical manifestation is eye and mouth dryness which, alongside fatigue and pain, contributes to poor health-related quality of life (HRQoL). A growing body of evidence recognises the adipose tissue as an active endocrine organ secreting bioactive mediators involved in metabolic and inflammatory disorders. A relationship between obesity and symptoms in SS has not yet been elucidated.Objectives:To explore potential associations bet

APA, Harvard, Vancouver, ISO, and other styles

13

Guo, Yujie, Aru Su, Huihui Tian, et al. "Transcriptomic Analysis of Spleen Revealed Mechanism of Dexamethasone-Induced Immune Suppression in Chicks." Genes 11, no. 5 (2020): 513. http://dx.doi.org/10.3390/genes11050513.

Full text

Abstract:

Stress-induced immunosuppression is a common problem in the poultry industry, but the specific mechanism of its effect on the immune function of chicken has not been clarified. In this study, 7-day-old Gushi cocks were selected as subjects, and a stress-induced immunosuppression model was successfully established via daily injection of 2.0 mg/kg (body weight) dexamethasone. We characterized the spleen transcriptome in the control (B_S) and model (D_S) groups, and 515 significant differentially expressed genes (SDEGs) (Fragments Per Kilobase of transcript sequence per Millions base pairs sequen

APA, Harvard, Vancouver, ISO, and other styles

14

Alexaki, Vassilia-Ismini, Vassiliki Pelekanou, George Notas, et al. "B-Cell Maturation Antigen (BCMA) Activation Exerts Specific Proinflammatory Effects in Normal Human Keratinocytes and Is Preferentially Expressed in Inflammatory Skin Pathologies." Endocrinology 153, no. 2 (2012): 739–49. http://dx.doi.org/10.1210/en.2011-1504.

Full text

Abstract:

TNFα is known to be expressed in human skin, regulating immune-related responses. Here we report that human normal skin keratinocytes express the members of the TNF superfamily members A proliferation-inducing ligand (APRIL; TNFSF13), B cell-activating factor (BAFF; TNFSF13B), and their receptors, B cell maturation antigen (BCMA; TNFRSF17) and transmembrane activator, calcium-modulator, and cyclophilin ligand interactor (TACI; TNFRSF13B), in a distinct spatial pattern. Our data show a differential expression of these molecules within epidermal layers and skin appendages, whereas the BAFF-speci

APA, Harvard, Vancouver, ISO, and other styles

15

Bastelica, Delphine, Alenka Mavri, Monique Verdier, Bruno Berthet, Irène Juhan-Vague та Marie-Christine Alessi. "Relationships between Fibrinolytic and Inflammatory Parameters in Human Adipose Tissue: Strong Contribution of TNFα Receptors to PAI-1 Levels". Thrombosis and Haemostasis 88, № 09 (2002): 481–87. http://dx.doi.org/10.1055/s-0037-1613241.

Full text

Abstract:

SummaryPlasminogen activator inhibitor type 1 (PAI-1), a risk marker of atherosclerosis, is highly expressed in adipose tissue from obese subjects. PAI-1 is also considered as an acute phase protein. Recently, adipose tissue has been described as a source of inflammatory cytokines. Therefore, our aim was to study the relationships between PAI-1, and IL-6, TNF, TNF receptors (TNFRSF1s) and TGFβ1, in plasma and adipose tissue from obese (n = 60) and lean (n = 28) subjects. Study has been extended to plasminogen activators (t-PA and u-PA).Compared to lean subjects, obese subjects exhibited higher

APA, Harvard, Vancouver, ISO, and other styles

16

Корытина, Г. Ф., Ю. Г. Азнабаева, М. Ю. Темнов, et al. "Molecular mechanisms of phenotypic heterogeneity of chronic obstructive pulmonary disease: the role of JAK / STAT-, NFKB1-signaling pathway and inflammatory response molecules." Nauchno-prakticheskii zhurnal «Medicinskaia genetika», no. 8(217) (August 31, 2020): 100–104. http://dx.doi.org/10.25557/2073-7998.2020.08.100-104.

Full text

Abstract:

Хроническая обструктивная болезнь легких (ХОБЛ) - это многофакторное хроническое воспалительное заболевание респираторной системы. Одной из причин трудностей в идентификации маркеров ХОБЛ является фенотипическая гетерогенность. Цель - идентификация новых молекулярных маркеров патогенетических изменений, связанных с фенотипической гетерогеностью ХОБЛ на основе анализа профиля экспрессии генов вовлеченных в развитие иммунного ответа в мононуклеарных клетках периферической крови и анализа ассоциации полиморфных вариантов новых кандидатных генов с развитием ХОБЛ. Проведен сравнительный анализ проф

APA, Harvard, Vancouver, ISO, and other styles

17

Rojas-Cartagena, Carmencita, Caroline B. Appleyard, Olga I. Santiago, and Idhaliz Flores. "Experimental Intestinal Endometriosis Is Characterized by Increased Levels of Soluble TNFRSF1B and Downregulation of Tnfrsf1a and Tnfrsf1b Gene Expression1." Biology of Reproduction 73, no. 6 (2005): 1211–18. http://dx.doi.org/10.1095/biolreprod.105.044131.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Sun, Yaoyao, Shanshan Li, Haiping Li, et al. "TNFRSF10A-LOC389641 rs13278062 But Not REST-C4orf14-POLR2B-IGFBP7 rs1713985 Was Found Associated With Age-Related Macular Degeneration in a Chinese Population." Investigative Opthalmology & Visual Science 54, no. 13 (2013): 8199. http://dx.doi.org/10.1167/iovs.13-12867.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Özdemir, K., H. Gürkan, S. Demir, et al. "Investigation of the relationship of TNFRSF11A gene polymorphisms with breast cancer development and metastasis risk in patients with BRCA1 or BRCA2 pathogenic variants living in the Trakya region of Turkey." Balkan Journal of Medical Genetics 23, no. 2 (2020): 49–58. http://dx.doi.org/10.2478/bjmg-2020-0016.

Full text

Abstract:

Abstract Modifying genes play an exclusive role in the genetic regulation of the risk of breast cancer development in women with a pathogenic variation of BRCA1 or BRCA2. Therefore, it has been suggested that TNFRSF11A, which is among those modifying genes present in breast cancer development, may have a significant role in patients with positive BRCA1 or BRCA2 variations. In our study, we investigated the probable effects of single nucleotide polymorphisms (SNPs) in the TNFRSF11A gene, such as rs4485469, rs9646629, rs34739845, rs17069904, rs 884205, rs4941129 on the risk of breast cancer in p

APA, Harvard, Vancouver, ISO, and other styles

20

Oróstica, María L., Lidia M. Zuñiga, Daniella Utz та ін. "Tumour necrosis factor-α is the signal induced by mating to shutdown a 2-methoxyestradiol nongenomic action necessary to accelerate oviductal egg transport in the rat". REPRODUCTION 145, № 2 (2013): 109–17. http://dx.doi.org/10.1530/rep-12-0389.

Full text

Abstract:

Mating shut down a 2-methoxyestradiol (2ME) nongenomic action necessary to accelerate egg transport in the rat oviduct. Herein, we investigated whether tumour necrosis factor-α (TNF-α) participates in this mating effect. In unmated and mated rats, we determined the concentration of TNF-α in the oviductal fluid and the level of the mRNA for Tnf-a (Tnf) and their receptors Tnfrsf1a and Tnfrsf1b in the oviduct tissues. The distribution of the TNFRSF1A and TNFRSF1B proteins in the oviduct of unmated and mated was also assessed. Finally, we examined whether 2ME accelerates oviductal egg transport i

APA, Harvard, Vancouver, ISO, and other styles

21

Bowers, Emily, Slaughter Anastasiya, and Daniel Lucas-Alcaraz. "Bone Marrow Granulocytes Drive Vascular and Hematopoietic Regeneration." Blood 128, no. 22 (2016): 427. http://dx.doi.org/10.1182/blood.v128.22.427.427.

Full text

Abstract:

Abstract In addition to eliminating host hematopoietic cells myeloablation also disrupts the blood vessels that sustain hematopoiesis. Regeneration of the bone marrow (BM) vasculature is necessary for hematopoietic recovery and survival after transplantation (Cell Stem Cell. 2009 Mar 6;4(3):263-74) but the mechanisms that drive vascular regeneration are not clear. We found that, fourteen days after lethal irradiation and transplantation, mice transplanted with 20x106 bone marrow nucleated cells (BMNC) had ~6-fold more CD45-Ter119-CD31+CD105+ endothelial cells (6.9x103 vs 0.96x103 EC/femur, p&l

APA, Harvard, Vancouver, ISO, and other styles

22

Hildebrand, Joanne M., Zhenghua Luo, Michelle Manske, et al. "A BAFF-R Mutation Associated with Non-Hodgkin Lymphoma Exhibits Altered TRAF Binding and Reveals New Insights Into Proximal BAFF-R Signaling." Blood 116, no. 21 (2010): 468. http://dx.doi.org/10.1182/blood.v116.21.468.468.

Full text

Abstract:

Abstract Abstract 468 The requirement for BAFF and BAFF-R in normal human and murine B cells is well studied, but there is also significant evidence to suggest that BAFF plays an important role in malignant B cell proliferation and survival. Serum BAFF levels are elevated in patients with non-Hodgkin lymphoma (NHL) and high BAFF levels correlate with aggressive disease and a poor response to therapy. There is also increasing genetic evidence suggesting an association between the development of human disease and genetic variation in genes encoding BAFF and its receptors. Mutations in TNFRSF13B

APA, Harvard, Vancouver, ISO, and other styles

23

Zheng, Shangyou, Huimou Chen, Yingxue Wang, et al. "Long non-coding RNA LOC389641 promotes progression of pancreatic ductal adenocarcinoma and increases cell invasion by regulating E-cadherin in a TNFRSF10A-related manner." Cancer Letters 371, no. 2 (2016): 354–65. http://dx.doi.org/10.1016/j.canlet.2015.12.010.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Topchieva, L. V., I. V. Kurbatova, O. P. Dudanova, and A. A. Shipovskaya. "ANALYSIS OF THE ASSOCIATION BETWEEN THE RS767455 T>C TNFRSF1A AND RS1061622 T>G TNFRSF1B POLYMORPHISMS AND NONALCOHOLIC STEATOHEPATITIS." Bulletin of Russian State Medical University, no. 1 (April 2018): 41–46. http://dx.doi.org/10.24075/brsmu.2018.008.

Full text

APA, Harvard, Vancouver, ISO, and other styles

25

Sakharnov, N. A., O. V. Utkin, E. N. Filatova, D. I. Knyazev, and N. B. Presnyakova. "Apoptosis- and survival-related gene mRNA profile in peripheral blood leukocytes in children with acute EBV infectious mononucleosis." Russian Journal of Infection and Immunity 9, no. 5-6 (2020): 723–34. http://dx.doi.org/10.15789/2220-7619-2019-5-6-723-734.

Full text

Abstract:

Acute EBV-associated mononucleosis develops mainly in children and in patients with functionally impaired immune system. Consequently, it may result in developing secondary immunodeficiency, neoplasms as well as diverse alterations in cell-mediated immune reaction. Despite extensively examining molecular mechanisms of EBV infection, it is also necessary seek for new molecular and genetic factors underlying pathogenesis of EBV-mediated mononucleosis and EBV-associated malignant cell transformation is necessary, which might be used in clinical practice to monitor clinical score as well as predic

APA, Harvard, Vancouver, ISO, and other styles

26

Xu, Bing, Yong Zhou, Manman Deng, et al. "Disulfiram Combined with Copper Induces Acute Myeloid Leukemic Stem-like KG1a Cell Apoptosis through TNF-a/ROS Pathway." Blood 126, no. 23 (2015): 4923. http://dx.doi.org/10.1182/blood.v126.23.4923.4923.

Full text

Abstract:

Abstract Acute myeloid leukemia (AML) is a heterogeneity disease initiating from a rare population of cells known as leukemia stem cells (LSCs), which have been a major hurdle for the success of acute myeloid leukemia chemotherapy. Therefore, new drugs targeting LSCs is urgently needed. Disulfiram (DS) has been used clinically as a safe anti-alcoholism drug for over 6 decades. Recent studies demonstrated that disulfiram combined with cooper (DS/Cu) have the antitumor activity in a wide range of cancer cell lines. CD34+ CD38- KG1a cells were previous found to have the characteristics of stem ce

APA, Harvard, Vancouver, ISO, and other styles

27

Messeha, Samia S., Najla O. Zarmouh, Abrar Asiri, and Karam F. A. Soliman. "Gene Expression Alterations Associated with Oleuropein-Induced Antiproliferative Effects and S-Phase Cell Cycle Arrest in Triple-Negative Breast Cancer Cells." Nutrients 12, no. 12 (2020): 3755. http://dx.doi.org/10.3390/nu12123755.

Full text

Abstract:

It is known that the Mediterranean diet is effective in reducing the risk of several chronic diseases, including cancer. A critical component of the Mediterranean diet is olive oil, and the relationship between olive oil consumption and the reduced risk of cancer has been established. Oleuropein (OL) is the most prominent polyphenol component of olive fruits and leaves. This compound has been shown to have potent properties in various types of cancers, including breast cancer. In the present study, the molecular mechanism of OL was examined in two racially different triple-negative breast canc

APA, Harvard, Vancouver, ISO, and other styles

28

Braggio, Esteban, Brian Patrick O'Neill, William Macon, Maria Beatriz Lopes, David Schiff, and Rafael Fonseca. "Characterization of the Copy-Number Changes In Primary CNS Lymphomas (PCNSL) by High-Resolution Array-Based Comparative Genomic Hybridization." Blood 116, no. 21 (2010): 995. http://dx.doi.org/10.1182/blood.v116.21.995.995.

Full text

Abstract:

Abstract Abstract 995 PCNSL is an aggressive primary brain tumor characterized by a perivascular accumulation of malignant lymphoid cells. Most PCNSLs (90%) are diffuse large B-cell lymphoma (DLBCL); the remaining 10% are poorly characterized low-grade, Burkitt, and T-cell lymphomas. Since most patients are biopsed, genomic analyses are challenging. To determine the pattern of genetic alterations in PCNSL, frozen samples and formalin fixed embedded paraffin sections from 17 EBV and HIV negative and immunocompetent patients were studied by array-based comparative genomic hybridization (aCGH) us

APA, Harvard, Vancouver, ISO, and other styles

29

Lines, Kate E., Mahsa Javid, Anita A. C. Reed, et al. "Genetic background influences tumour development in heterozygous Men1 knockout mice." Endocrine Connections 9, no. 5 (2020): 426–37. http://dx.doi.org/10.1530/ec-20-0103.

Full text

Abstract:

Multiple endocrine neoplasia type 1 (MEN1), an autosomal dominant disorder caused by MEN1 germline mutations, is characterised by parathyroid, pancreatic and pituitary tumours. MEN1 mutations also cause familial isolated primary hyperparathyroidism (FIHP), a milder condition causing hyperparathyroidism only. Identical mutations can cause either MEN1 or FIHP in different families, thereby implicating a role for genetic modifiers in altering phenotypic expression of tumours. We therefore investigated the effects of genetic background and potential for genetic modifiers on tumour development in a

APA, Harvard, Vancouver, ISO, and other styles

30

Wei, Jingsun, Xiaoxu Ge, Yang Tang, et al. "An Autophagy-Related Long Noncoding RNA Signature Contributes to Poor Prognosis in Colorectal Cancer." Journal of Oncology 2020 (October 21, 2020): 1–13. http://dx.doi.org/10.1155/2020/4728947.

Full text

Abstract:

Purpose. Colorectal cancer is one of the most common malignant primary tumors, prone to metastasis, and associated with a poor prognosis. As autophagy is closely related to the development and treatment of colorectal cancer, we investigated the potential prognostic value of long noncoding RNA (lncRNA) associated with autophagy in colorectal cancer. Methods. In this study, we acquired information on the expression of lncRNAs in colorectal cancer from the Cancer Genome Atlas (TCGA) database and found that 860 lncRNAs were associated with autophagy-related genes. Subsequently, univariate Cox regr

APA, Harvard, Vancouver, ISO, and other styles

31

Zhou, Cong, Ranran Pan, Haochang Hu, et al. "TNFRSF10C methylation is a new epigenetic biomarker for colorectal cancer." PeerJ 6 (September 13, 2018): e5336. http://dx.doi.org/10.7717/peerj.5336.

Full text

Abstract:

Background Abnormal methylation of TNFRSF10C was found to be associated with different types of cancers, excluding colorectal cancer (CRC). In this paper, the performance of TNFRSF10C methylation in CRC was studied in two stages. Method The discovery stage was involved with 38 pairs of CRC tumor and paired adjacent non-tumor tissues, and 69 pairs of CRC tumor and paired adjacent non-tumor tissues were used for the validation stage. Quantitative methylation specific PCR (qMSP) method and percentage of methylated reference (PMR) were used to test and represent the methylation level of TNFRSF10C,

APA, Harvard, Vancouver, ISO, and other styles

32

Pierce, Andrew, Maria Secrier, Emma V. Jones, et al. "Immunologically relevant gene expression as prognostic biomarker in squamous cell carcinoma of the head and neck." Journal of Clinical Oncology 35, no. 15_suppl (2017): e17542-e17542. http://dx.doi.org/10.1200/jco.2017.35.15_suppl.e17542.

Full text

Abstract:

e17542 Background: Expression of genes known to be integral to anti-tumour activity may be prognostic for patient outcomes in SCCHN. We hypothesized that broad categories of immune function would be responsible for anti-tumor activity. Methods: A study was conducted using data from patient medical records and analysis of archival tumour samples. Patients were ≥18 years old, diagnosed with SCCHN between 1989 and 2015 (n = 119). We quantified the expression of an annotated list of 71 aggregated genes selected to represent a variety of immunological activities: chemokines and receptors, interfero

APA, Harvard, Vancouver, ISO, and other styles

33

Nezos, Adrianos, Ourania D. Argyropoulou, Eleni Klinaki, et al. "Molecular and clinical spectrum of four pedigrees of TRAPS in Greece: results from a national referral center." Rheumatology 59, no. 6 (2019): 1241–46. http://dx.doi.org/10.1093/rheumatology/kez424.

Full text

Abstract:

Abstract Objective Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is a rare autosomal dominantly inherited autoinflammatory disease caused by mutations of the TNFRSF1A gene. To address the association between TNFRSF1A mutations and clinical phenotype, we analyzed four pedigrees of TRAPS patients. Methods Four Greek patients with TRAPS-like clinical features were screened for TNFRSF1A mutations by sequencing exons 2, 3 and 4. Following positive testing, twenty-two members of their families were also genetically and clinically screened. Results Twenty-six members of four unr

APA, Harvard, Vancouver, ISO, and other styles

34

Топчиева, Людмила Владимировна, Ирина Валерьевна Курбатова, Ольга Петровна Дуданова, et al. "GENE POLYMORPHISM OF PROINFLAMMATORY CYTOKINES (TNF, IL6) AND THEIR RECEPTORS (TNFRSF1A, TNFRSF1B, IL6R): IMPLICATIONS FOR NON-ALCOHOLIC FATTY LIVER DISEASE." Proceedings of the Karelian Research Centre of the Russian Academy of Sciences, no. 5 (May 22, 2017): 3. http://dx.doi.org/10.17076/eb568.

Full text

APA, Harvard, Vancouver, ISO, and other styles

35

Arnez, Maya Fernanda Manfrin, Larissa Soares Nogueira Ribeiro, Gabriel Dessotti Barretto, Patrícia Maria Monteiro, Edilson Ervolino, and Maria Bernadete Sasso Stuani. "RANK/RANKL/OPG Expression in Rapid Maxillary Expansion." Brazilian Dental Journal 28, no. 3 (2017): 296–300. http://dx.doi.org/10.1590/0103-6440201601116.

Full text

Abstract:

Abstract The aim of this study was to evaluate osteoclastogenesis signaling in midpalatal suture after rapid maxillary expansion (RME) in rats. Thirty male Wistar rats were randomly assigned to two groups with 15 animals each: control (C) and RME group. RME was performed by inserting a 1.5-mm-thick circular metal ring between the maxillary incisors. The animals were euthanized at 3, 7 and 10 days after RME. qRT-PCR was used to evaluate expression of Tnfsf11 (RANKL), Tnfrsf11a (RANK) and Tnfrsf11b (OPG). Data were submitted to statistical analysis using two-way ANOVA followed by Tukey test (a=0

APA, Harvard, Vancouver, ISO, and other styles

36

Ribeiro, Larissa Nogueira Soares, Patrícia Maria Monteiro, Gabriel Dessotti Barretto, Kelly Galisteu Luiz, Sandra Yasuyo Fukada Alves, and Maria Bernadete Sasso Stuani. "The Effect of Cigarette Smoking And Low-Level Laser Irradiation in RANK/RANKL/OPG Expression." Brazilian Dental Journal 31, no. 1 (2020): 57–62. http://dx.doi.org/10.1590/0103-6440202002519.

Full text

Abstract:

Abstract The objective of this study was to investigate the effects of low-level laser therapy (LLLT) and cigarette smoke on alveolar socket osteoclastogenesis signaling after tooth extraction, in rats. Sixty male Wistar rats were randomly assigned to four groups with 15 animals each: Control Group (with right maxillary molar extraction - ME), Experimental I (with ME and LLLT), Experimental II (with ME and cigarette smoke) and Experimental III group (with ME, LLLT and cigarette smoke). Euthanasia was performed at 3, 7 and 14 days postoperative. qRT-PCR was used to evaluate expression of Tnfrsf

APA, Harvard, Vancouver, ISO, and other styles

37

Yu, Zhijuan, Liguo Wang, and Xiujuan Li. "MiR-3150b-3p inhibits the proliferation and invasion of cervical cancer cells by targeting TNFRSF11a." Journal of Investigative Medicine 68, no. 6 (2020): 1166–70. http://dx.doi.org/10.1136/jim-2020-001284.

Full text

Abstract:

The objective of this study was to determine the role of miR-3150b-3p in the cervical cancer (CC) progression. Real-time PCR and western blot analysis were conducted to test the expression of miR-3150b-3p, TNFRSF11a and p38 mitogen-activated protein kinase (MAPK) signaling pathway. The interaction between miR-3150b-3p and TNFRSF11a was verified by luciferase assay. Cell proliferation, migration and invasion were determined by CCK-8, wound healing and Transwell assays. In this study, we showed that miR-3150b-3p was significantly downregulated in CC cell lines. Additionally, miR-3150b-3p markedl

APA, Harvard, Vancouver, ISO, and other styles

38

Yao, Lijun, Reyka G. Jayasinghe, Tianjiao Wang, et al. "Myeloma Cell Associated Therapeutic Protein Discovery Using Single Cell RNA-Seq Data." Blood 136, Supplement 1 (2020): 4–5. http://dx.doi.org/10.1182/blood-2020-142205.

Full text

Abstract:

Multiple myeloma (MM) is a hematological cancer of the antibody-secreting plasma cells. Despite therapeutic advancements, MM remains incurable due to high incidence of drug-resistant relapse. In recent years, targeted immunotherapies, which take advantage of the immune system's cytotoxic defenses to specifically eliminate tumor cells expressing certain cell surface and intracellular proteins have shown promise in combating this and other B cell hematologic malignancies. A major limitation in the development of these therapies lies in the discovery of optimal candidate targets, which require bo

APA, Harvard, Vancouver, ISO, and other styles

39

Mavri, Alenka, Delphine Bastelica, Marjorie Poggi, et al. "Polymorphism A36G of the tumor necrosis factor receptor 1 gene is associated with PAI-1 levels in obese women." Thrombosis and Haemostasis 97, no. 01 (2007): 62–66. http://dx.doi.org/10.1160/th06-06-0314.

Full text

Abstract:

SummaryThe tumor necrosis factor (TNF) pathway may be implicated in etiopathogenesis of PAI-1 overexpression during obesity. The aim of this study was to investigate the influence of polymorphismA36G of the TNF receptor 1 (TNFRSF1A +36A/G) on plasma concentrations of PAI-1 in 163 obese (31 with the metabolic syndrome, MetS) and 150 lean, healthy women. Genotypic and allele frequencies did not significantly differ between obese and lean subjects. TNFRSF1A genotypes were significantly associated with sTNFR1 plasma levels in obese women only (p<0.01); TNFRSF1A +36G/G obese carriers exhibited h

APA, Harvard, Vancouver, ISO, and other styles

40

HAVLA, JOACHIM, PETER LOHSE, LISA ANN GERDES, REINHARD HOHLFELD, and TANIA KÜMPFEL. "Symptoms Related to Tumor Necrosis Factor Receptor 1-associated Periodic Syndrome, Multiple Sclerosis, and Severe Rheumatoid Arthritis in Patients Carrying the TNF Receptor Superfamily 1A D12E/p.Asp41Glu Mutation." Journal of Rheumatology 40, no. 3 (2013): 261–64. http://dx.doi.org/10.3899/jrheum.120729.

Full text

Abstract:

Objective.Tumor necrosis factor (TNF) receptor 1–associated periodic syndrome (TRAPS) is an autoinflammatory disorder caused by autosomal dominantly inherited mutations in the TNF receptor superfamily 1A (TNFRSF1A) gene. The D12E substitution has been described only once to date, in a 4-year-old boy with fever.Methods.For DNA sequence analysis of the TNFRSF1A gene, genomic DNA was isolated, amplified by PCR, purified, and sequenced.Results.We describe 3 families (8 subjects) with the TNFRSF1A D12E substitution and TRAPS-related symptoms, in 4 cases associated with the autoimmune diseases multi

APA, Harvard, Vancouver, ISO, and other styles

41

Shao, Xiao-Qing, Xiao-Lian Ding, Kaida Mu, et al. "Associations of TNFRSF1A Polymorphisms with Autoimmune Thyroid Diseases: A Case-Control Study." Hormone and Metabolic Research 50, no. 02 (2018): 117–23. http://dx.doi.org/10.1055/s-0043-124435.

Full text

Abstract:

AbstractPrevious studies have shown associations of polymorphisms in the tumor necrosis factor (TNF) receptor super family member 1A (TNFRSF1A) gene with several groups of inflammatory and autoimmune related diseases, but associations of TNFRSF1A polymorphisms with autoimmune thyroid diseases (AITD), mainly including two sub-types of Hashimoto’s thyroiditis (HT) and Graves’ disease (GD), in the Chinese Han population is unclear. A case-control study of 1812 subjects (965 AITD patients and 847 unrelated healthy controls) was conducted to assess AITD associations with five single nucleotide poly

APA, Harvard, Vancouver, ISO, and other styles

42

Xu, Fengyan, Guiqin Zhou, Shaoli Han та ін. "Association of TNF-α, TNFRSF1A and TNFRSF1B Gene Polymorphisms with the Risk of Sporadic Breast Cancer in Northeast Chinese Han Women". PLoS ONE 9, № 7 (2014): e101138. http://dx.doi.org/10.1371/journal.pone.0101138.

Full text

APA, Harvard, Vancouver, ISO, and other styles

43

You, Liyi, Hao Chen, Lixin Xu, and Xun Li. "Overexpression of miR-29a-3p Suppresses Proliferation, Migration, and Invasion of Vascular Smooth Muscle Cells in Atherosclerosis via Targeting TNFRSF1A." BioMed Research International 2020 (September 7, 2020): 1–15. http://dx.doi.org/10.1155/2020/9627974.

Full text

Abstract:

Objective. Increasing evidence highlights the significance of microRNAs (miRNAs) in the progression of atherosclerosis (AS). Our aim was to probe out the role and regulatory mechanism of miR-29a-3p in AS. Methods. An in vivo model of AS was conducted by high-fat diet ApoE-/- mice. Oxidized low-density lipoprotein- (ox-LDL-) exposed vascular smooth muscle cells (VSMCs) were utilized as an in vitro of AS. Serum levels of total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) were detected. Hematoxylin and eosin (H&

APA, Harvard, Vancouver, ISO, and other styles

44

stojanov, silvia, and michael f. mcdermott. "the tumour necrosis factor receptor-associated periodic syndrome: current concepts." Expert Reviews in Molecular Medicine 7, no. 22 (2005): 1–18. http://dx.doi.org/10.1017/s1462399405009749.

Full text

Abstract:

the tumour necrosis factor receptor (tnfr)-associated periodic syndrome (traps) is an autosomal dominant, multisystemic, autoinflammatory disorder caused by mutations in the tnfr1 gene (tnfrsf1a). traps seems to be the most common hereditary periodic fever (hpf) syndrome in some western populations, and the second most prevalent hpf worldwide, behind familial mediterranean fever (fmf). the proteins involved in susceptibility to traps (tnfrsf1a) and fmf (pyrin) are both members of the death-domain-fold superfamily. mutations affecting these proteins might cause dysregulation of innate immune re

APA, Harvard, Vancouver, ISO, and other styles

45

Cortelezzi, Agostino, Umberto Gianelli, Valentina Vaira, et al. "Apoptosis Taqman Low-Density Array: Analysis of Programmed Cell Death Patway in CLL." Blood 110, no. 11 (2007): 3369. http://dx.doi.org/10.1182/blood.v110.11.3369.3369.

Full text

Abstract:

Abstract The clinical course of CLL is highly heterogeneous: some patients progress rapidly thus requiring early chemotherapy whereas others exhibit a stable disease over years. Gene expression studies have identified a relatively small number of genes that are differentially expressed between these subsets. Resistance to programmed cell death seems to be one of the preferential pathways of neoplastic B cells to survive and to develop resistance to therapy. We investigated by MicroFluidic Card™ technology patients affected by untreated CLL cells for alterations of agonist and antagonist apopto

APA, Harvard, Vancouver, ISO, and other styles

46

Maeda, Shingo, Koichi Ohno, Aki Fujiwara-Igarashi, Hirotaka Tomiyasu, Yasuhito Fujino, and Hajime Tsujimoto. "Methylation of TNFRSF13B and TNFRSF13C in duodenal mucosa in canine inflammatory bowel disease and its association with decreased mucosal IgA expression." Veterinary Immunology and Immunopathology 160, no. 1-2 (2014): 97–106. http://dx.doi.org/10.1016/j.vetimm.2014.04.005.

Full text

APA, Harvard, Vancouver, ISO, and other styles

47

Barbagallo, Davide, Angelo Giuseppe Condorelli, Salvatore Piro та ін. "CEBPA exerts a specific and biologically important proapoptotic role in pancreatic β cells through its downstream network targets". Molecular Biology of the Cell 25, № 16 (2014): 2333–41. http://dx.doi.org/10.1091/mbc.e14-02-0703.

Full text

Abstract:

Transcription factor CEBPA has been widely studied for its involvement in hematopoietic cell differentiation and causal role in hematological malignancies. We demonstrate here that it also performs a causal role in cytokine-induced apoptosis of pancreas β cells. Treatment of two mouse pancreatic α and β cell lines (αTC1-6 and βTC1) with proinflammatory cytokines IL-1β, IFN-γ, and TNF-α at doses that specifically induce apoptosis of βTC1 significantly increased the amount of mRNA and protein encoded by Cebpa and its proapoptotic targets, Arl6ip5 and Tnfrsf10b, in βTC1 but not in αTC1-6. Cebpa k

APA, Harvard, Vancouver, ISO, and other styles

48

Choi, Eun-Kyung, Woon-Ki Kim, Ok-Joo Sul, et al. "TNFRSF14 deficiency protects against ovariectomy-induced adipose tissue inflammation." Journal of Endocrinology 220, no. 1 (2014): 25–33. http://dx.doi.org/10.1530/joe-13-0341.

Full text

Abstract:

To elucidate the role of tumor necrosis factor receptor superfamily member 14 (TNFRSF14) in metabolic disturbance due to loss of ovarian function, ovariectomy (OVX) was performed in TNFRSF 14-knockout mice. OVX increased fat mass and infiltration of highly inflammatory CD11c cells in the adipose tissue (AT), which was analyzed by flow cytometry, and resulted in disturbance of glucose metabolism, whereas TNFRSF14 deficiency attenuated these effects. TNFRSF14 deficiency decreased recruitment of CD11c-expressing cells in AT and reduced the polarization of bone marrow-derived macrophages to M1. Up

APA, Harvard, Vancouver, ISO, and other styles

49

Galon, Jérôme, Ivona Aksentijevich, Michael F. McDermott, John J. O’Shea, and Daniel L. Kastner. "TNFRSF1A mutations and autoinflammatory syndromes." Current Opinion in Immunology 12, no. 4 (2000): 479–86. http://dx.doi.org/10.1016/s0952-7915(00)00124-2.

Full text

APA, Harvard, Vancouver, ISO, and other styles

50

Kümpfel, Tania, and Reinhard Hohlfeld. "TNFRSF1A, TRAPS and multiple sclerosis." Nature Reviews Neurology 5, no. 10 (2009): 528–29. http://dx.doi.org/10.1038/nrneurol.2009.154.

Full text

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!