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Journal articles on the topic 'To 1535(Category III)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Onundi, L.O, M.B Oumarou, and Otuagbu Philip. "CLASSIFICATION OF NIGERIA WIND ISOPLETHS FOR STRUCTURAL PURPOSES." Continental J. Engineering Sciences 4 (July 22, 2009): 48–55. https://doi.org/10.5281/zenodo.833703.

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The paper reviewed the useful details of the Soboyejo Isopleths and the Nigerian Meteorological Agency wind Documentation map produced for Nigeria. Discrepancies were observed in the interpretations given to the data produced by the Agency. The researchers used a mathematical relationship between, the Soboyejo’s and the Nigerian Meteorological Agency data to produce results which correspond to 100 year mean recurrent interval. Gumbel Type I distribution model of yearly highest gust was used to analyse the data for some scattered points; while the Microsoft Office Excel was used as the tool for

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Shaz, Beth H., Jeffrey L. Winters, Nicholas Bandarenko, and Zbigniew M. Szczepiorkowski. "How we approach an apheresis request for a Category III, Category IV, or noncategorized indication." Transfusion 47, no. 11 (2007): 1963–71. http://dx.doi.org/10.1111/j.1537-2995.2007.01511.x.

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Suntheralingam, Sivisan, Chun-Po Steve Fan, Oscar Calvillo-Argüelles, Husam Abdel-Qadir, Eitan Amir, and Paaladinesh Thavendiranathan. "Evaluation of Risk Prediction Models to Identify Cancer Therapeutics Related Cardiac Dysfunction in Women with HER2+ Breast Cancer." Journal of Clinical Medicine 11, no. 3 (2022): 847. http://dx.doi.org/10.3390/jcm11030847.

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Cancer-therapeutics-related cardiac dysfunction (CTRCD) is an important concern in women receiving trastuzumab therapy for HER2+ breast cancer. However, the ability to assess CTRCD risk remains limited. In this retrospective cohort study, we apply three published risk prediction models (Ezaz et al., NSABP-31 cardiac risk scores (CRS), and HFA-ICOS trastuzumab proforma) to 629 women (mean age 52.4 ± 10.9 years) with Stage I-III HER2+ breast cancer treated with trastuzumab ± anthracyclines to assess their performance to identify CTRCD during or immediately post treatment. Using these models, pat

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Zaritsky, Dennis, Richard Donnerstein, Ananthan Karunakaran, et al. "Systematically Measuring Ultra-diffuse Galaxies (SMUDGes). III. The Southern SMUDGes Catalog." Astrophysical Journal Supplement Series 261, no. 2 (2022): 11. http://dx.doi.org/10.3847/1538-4365/ac6ceb.

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Abstract We present a catalog of 5598 ultra-diffuse galaxy (UDG) candidates with effective radius r e > 5.″3 distributed throughout the southern portion of the DESI Legacy Imaging Survey covering ∼15,000 deg2. The catalog is most complete for physically large (r e > 2.5 kpc) UDGs lying in the redshift range 1800 ≲ cz/km s−1 ≲ 7000, where the lower bound is defined by where incompleteness becomes significant for large objects on the sky and the upper bound by our minimum angular size selection criterion. Because physical size is integral to the definition of a UDG, we develop a method of

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Ghafoor, Muzammal, Farooq Ikram, Saeed Zaman, Junaid Bashir, Samina Tabassum, and Muhammad Waleed Babar. "Celiac Disease Investigation with Marsh Classification in Paediatric Population." Pakistan Armed Forces Medical Journal 72, no. 4 (2022): 1164–67. http://dx.doi.org/10.51253/pafmj.v72i4.7212.

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Objective: To determine the celiac disease using Marsh classification in the paediatric population at the Pak Emirates Military Hospital. Study Design: Cross-sectional study. Place and Duration of Study: Department of Paediatrics, Pak Emirates Military Hospital Rawalpindi Pakistan, from Aug 2020 till Mar 2021. Methodology: Patients of either gender aged 1 to 14 years with three or more clinical features of celiac disease such as chronic diarrhoea, any degree of malnutrition, short stature, abdominal distension, anaemia, and clubbing at the time of admission, were included in

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Castellano, Marco, Lorenzo Napolitano, Adriano Fontana, et al. "JWST NIRSpec Spectroscopy of the Remarkable Bright Galaxy GHZ2/GLASS-z12 at Redshift 12.34." Astrophysical Journal 972, no. 2 (2024): 143. http://dx.doi.org/10.3847/1538-4357/ad5f88.

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Abstract We spectroscopically confirm the M UV = −20.5 mag galaxy GHZ2/GLASS-z12 to be at redshift z = 12.34. The source was selected via NIRCam photometry in GLASS-JWST Early Release Science data, providing the first evidence of a surprising abundance of bright galaxies at z ≳ 10. The NIRSpec PRISM spectrum shows detections of N iv, C iv, He ii, O iii, C iii, O ii, and Ne iii lines and the first detection at high redshift of the O iii Bowen fluorescence line at 3133 Å rest frame. The prominent C iv line with rest-frame equivalent width (EW) ≈ 46 Å puts GHZ2 in the category of extreme C iv emi

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Kimsey-Miller, Brooke, Samantha W. Brunker та John J. Salzer. "The Environments of Green Pea Galaxies. II. The Hα Dot Sample". Astrophysical Journal 977, № 1 (2024): 79. https://doi.org/10.3847/1538-4357/ad8b4e.

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Abstract We use spectroscopic redshifts obtained with the WIYN 3.5 m telescope to study the local galactic environment around 18 Green Pea (GP) galaxies. Our sample of GPs were discovered in the Hα Dot Survey via their [O iii]λ5007 emission and span the redshift range 0.32 < z < 0.34. We present the environmental analyses near the location of the Hα Dot GPs. We utilize three different density estimators, chosen based on the geometry of the redshift survey data within the Hα Dot GP fields. We classify each Hα Dot GP into an environment category, from extremely isolated to highly clustered

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Hess, Georg, Lisa Kang, and Pádraig J. Moran. "Effect of Prognostic Risk Classification on Temsirolimus Efficacy and Safety Outcomes in Patients with Relapsed/Refractory Mantle Cell Lymphoma." Blood 118, no. 21 (2011): 2708. http://dx.doi.org/10.1182/blood.v118.21.2708.2708.

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Abstract Abstract 2708 Background: The simplified Mantle Cell Lymphoma International Prognostic Index (MIPI) has been shown to be a good predictor of patient survival (Blood 2008;111:558–65; Blood 2010;115:1530–1533). This post hoc study analyzed data from a randomized, phase III clinical trial investigating temsirolimus (TEM) in relapsed/refractory mantle cell lymphoma (MCL) in which TEM 175/75 (175 mg for first 3 weeks then 75 mg weekly) demonstrated significantly longer progression-free survival (PFS) vs investigator's choice of therapy (INV; 4.8 vs 1.9 months, respectively; hazard ratio [H

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Sania Bano, Allah Nawaz, Naeem Ahmad, Ahmad Hassan, Ammara Noor, and Khurram Nawaz. "Pattern of Mortality in Peritonitis Patients with different Mannheim Peritonitis Index Categories." Indus Journal of Bioscience Research 3, no. 4 (2025): 357–60. https://doi.org/10.70749/ijbr.v3i4.434.

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Background: Peritonitis caused by hollow viscus perforation is a frequent surgical emergency. Every surgeon has the task of accurately diagnosing and managing this condition. This resulted in the creation of illness severity grading systems that would help with care and accurately forecast future outcomes. Objective: To evaluate Mannheim Peritonitis Index in predicting the mortality among patients with peritonitis and to determine the pattern of mortality in peritonitis patients with different MPI categories. Methodology: This descriptive case series was conducted in department of General Surg

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Leo, Patrick, Niha Beig, Barzin Y. Nabet, et al. "Abstract 2458: Prediction of atezolizumab benefit in NSCLC by computational pathology: Retrospective validation in a phase III trial." Cancer Research 85, no. 8_Supplement_1 (2025): 2458. https://doi.org/10.1158/1538-7445.am2025-2458.

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Abstract Background: Anti-PD-(L)1 therapies are widely used to treat non-small cell lung cancer (NSCLC). However, suboptimal disease response motivates development of biomarkers to identify patients likely to benefit from these therapies. Here, we demonstrate an artificial intelligence (AI) powered model that analyzes the tumor microenvironment (TME) of hematoxylin and eosin (H&E) images to predict patient benefit from atezolizumab (anti-PD-L1) in NSCLC. Methods: 1, 243 digitized H&E slides were collected from two trials of atezolizumab versus docetaxel in second-line advanced NSCLC. P

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Krivorotko, Petr, Evgeniy Imyanitov, Diana Enaldieva, et al. "Abstract PO5-21-07: Mitomycin: its developmental role in the treatment of patients with BRCA - associated triple-negative early and locally advanced breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO5–21–07—PO5–21–07. http://dx.doi.org/10.1158/1538-7445.sabcs23-po5-21-07.

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Abstract Rationale. BRCA-associated triple-negative breast cancer (TNBC) is one of the most aggressive subtypes of breast cancer with high sensitivity to chemotherapy, which leads to increased interest in the development of new strategies for neoadjuvant treatment of patients with a triple-negative tumor phenotype. The aim of the study is to determine the role of adding platinum to standard neoadjuvant systemic therapy in patients with primary BRCA-associated TNBC, to evaluate the effect of platinum preparations on relapse-free survival in patients of this category, to determine the role of ad

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Darr, Christopher, Lennart Möller, Niklas Schürger, et al. "Incidence and survival in patients with urachal carcinoma: Cancer registry analysis between 2008 and 2019." Journal of Clinical Oncology 41, no. 6_suppl (2023): 480. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.480.

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480 Background: Urachal carcinoma (UrC) is a rare and poorly studied cancer without evidence-based treatment strategies. Due to the low prevalence of this cancer, only sparse data on its incidence and survival are available. Therefore, we analyzed the incidence and survival rates of patients with UrC in North Rhine-Westphalia (NRW), a state of the Federal Republic of Germany. Methods: UrC (ICD-O-3: C67.7) diagnosed between 2008 and 2019 were identified via the NRW Cancer Registry (population 18 million) and classified according to Mayo-staging and T-category. Mayo stage was based on the TNM cl

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Gnant, Michael, Amylou C. Dueck, Sophie Frantal, et al. "Abstract GS1-07: Adjuvant palbociclib in HR+/HER2- early breast cancer: Final results from 5,760 patients in the randomized phase III PALLAS trial." Cancer Research 82, no. 4_Supplement (2022): GS1–07—GS1–07. http://dx.doi.org/10.1158/1538-7445.sabcs21-gs1-07.

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Abstract Background Advances in the multidisciplinary care of hormone-receptor positive (HR+) early breast cancer (eBC) have markedly improved clinical outcomes: however, disease recurrence may still occur, particularly in patients (pts) with moderate or high-risk cancers at the time of diagnosis. The use of CDK4/6 inhibitors (CDK4/6i) combined with endocrine therapy (ET) is a standard of care for advanced breast cancer, supporting the rationale to study CDK4/6i in the eBC setting. Here we present the final protocol-planned analyses of the global phase III PALLAS trial investigating whether th

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Yoder, Rachel, Jennifer Yen, Mehran Karimzadeh, et al. "Abstract 5215: Orphan noncoding RNA (oncRNA) liquid biopsy assay is prognostic for survival in patients with triple-negative breast cancer (TNBC) and residual disease." Cancer Research 84, no. 6_Supplement (2024): 5215. http://dx.doi.org/10.1158/1538-7445.am2024-5215.

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Abstract Introduction: Residual disease (RD) after neoadjuvant systemic therapy is associated with high recurrence risk in patients with TNBC. oncRNAs are a novel category of small RNAs that are largely absent in healthy tissue but enriched in tumors and can be detected using a blood-based assay. This study investigated impact of an oncRNA recurrence risk model on outcomes in TNBC patients with RD. Methods: Study population included stage I-III TNBC patients with RD and available end-of-treatment (EOT) serum samples who were enrolled in a multisite prospective cohort study. EOT samples were co

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Nomoto, Hidetoshi, Kei Yamamoto, Satoshi Kutsuna, et al. "Evaluation of potential rabies exposure among Japanese international travelers: A retrospective descriptive study." PLOS ONE 18, no. 8 (2023): e0287838. http://dx.doi.org/10.1371/journal.pone.0287838.

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Background Although Japan has been a rabies-free country for >50 years, a few cases have been reported among people traveling abroad. This study aimed to investigate animal exposure among Japanese travelers using the Japanese Registry for Infectious Diseases from Abroad (J-RIDA). Method In this retrospective analysis, we examined Japanese overseas travelers with animal exposure, as included the J-RIDA database, reported from October 1, 2017, to October 31, 2019, with a focus on pre-exposure prophylaxis (PrEP) administration and the animals to which the patients were exposed. Results Among t

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Sanchez-Bayona, Rodrigo, Santiago Terán, Ana Sánchez De Torre, et al. "Abstract P5-13-24: Efficacy of first line CDK4/6 inhibitors in HER2-low vs HER2-zero, hormone receptor positive, HER2 negative metastatic breast cancer." Cancer Research 82, no. 4_Supplement (2022): P5–13–24—P5–13–24. http://dx.doi.org/10.1158/1538-7445.sabcs21-p5-13-24.

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Abstract Introduction: CDK4/6 inhibitors are the standard of care in the vast majority of patients with metastatic breast cancer (MBC) in first line setting. HER2-low expression, defined as IHC score of 1+ or 2+ with negative ISH assay, has been associated with resistance to CDK4/6 inhibitors. This has not yet been explored for advanced disease in the first line setting. We aimed to analyze the efficacy of CDK4/6 inhibitors in this subset of patients compared to HER2-zero tumors. Methods: We identified patients with positive hormone receptors and HER2 negative metastatic breast cancer treated

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Kaur, Mandeep, Anne Patterson, Julissa Molina-Vega, et al. "Abstract P6-08-09: Self-identified race and Area Deprivation Index in patients with invasive lobular carcinoma of the breast: associations with tumor characteristics and event free survival." Cancer Research 83, no. 5_Supplement (2023): P6–08–09—P6–08–09. http://dx.doi.org/10.1158/1538-7445.sabcs22-p6-08-09.

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Abstract Objectives: Investigators have shown a relationship between race/ethnicity and survival in invasive lobular carcinoma (ILC), the second most common type of breast cancer. While non-white patients with ILC were shown to have worse outcomes, there are no data evaluating the impact of socioeconomic factors. Herein we evaluated the relationship between self-reported race and socioeconomic factors with tumor features and outcomes in early-stage patients with ILC. Methods: We used chi-squared tests, t-tests, the Kruskal-Wallis test, multivariate Cox proportional hazards models, and tests fo

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Silva, Susana Serpa. "Angra do Heroísmo, Azores, Portugal. World Heritage City: An invitation to Cultural Tourism." Revista Rosa dos Ventos - Turismo e Hospitalidade 13, no. 2 (2021): 434–59. http://dx.doi.org/10.18226/21789061.v13i2p434.

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The city of Angra, whose name derives from the small cove that serves as its port, is the oldest one in the Azores Archipelago, Portugal. It is located on the southern coast of Terceira Island and has this category by letter of D. João III of 21st August 1534. From the beginning, the importance of its port for the Atlantic navigation and as a scale of the designated India’s Career led chronicler Gaspar Frutuoso, by the end of the 16th century, to call it the ‘Western Ocean Sea Scale’. Alongside a significant role in the Atlantic History, the city also played an active part in the History of Po

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Schwarz, Roderich, David D. Smith, and Rebecca A. Nelson. "Changing patterns in presentation and therapy of esophagogastric junction cancers in the United States." Journal of Clinical Oncology 32, no. 3_suppl (2014): 22. http://dx.doi.org/10.1200/jco.2014.32.3_suppl.22.

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22 Background: Esophagogastric junction cancer (EGJC) has recently been included within the esophageal cancer (EC) AJCC TNM staging criteria. Trends in clinical presentation, therapeutic approach and outcomes are of interest. Methods: We identified EGJCs from the U.S. population SEER database and examined incidence, demographic, therapeutic and outcomes information. Siewert classification-related EGJC subtype-associated findings were also examined. Results: EGJC age-adjusted incidence rates (x10-5) have increased from 3.3 in 1973 to 7.5 in 2009. While the incidence rate for females has remaine

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Wakako, Tajiri. "Abstract P4-05-11: The clinical importance of the new category, ER low-positive in the ER expression HER2 negative early breast cancer." Cancer Research 82, no. 4_Supplement (2022): P4–05–11—P4–05–11. http://dx.doi.org/10.1158/1538-7445.sabcs21-p4-05-11.

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Abstract &lt;Background&gt;In the latest updated ASCO/CAP guideline, a new category, ER low-positive was introduced, which are determined by the 1% to10 % of positive staining of the tumor nuclei for ER. However clinical meaning of ER-low positive was unclear compared with ER- positive or ER-negative in HER2 negative breast cancer. &lt;Purpose&gt; In order to clarify the clinicopathological features of ER-low positive breast cancer, we compared the clinicopathological factors and prognosis among three groups, ER negative, ER-low positive, and ER-positive groups in the patients

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Clelland, Elle, Harriet T. Rothschild, Anne Patterson, et al. "Abstract P2-03-16: Quantifying estrogen and progesterone receptor status in early-stage invasive lobular carcinoma of the breast: associated factors and outcomes in an institutional series." Cancer Research 83, no. 5_Supplement (2023): P2–03–16—P2–03–16. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-03-16.

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Abstract Background: Recent guidelines regarding estrogen (ER) and progesterone (PR) receptor testing from the American Society of Clinical Oncology and College of American Pathologists defined a new reporting category of ER-low positive breast cancer for tumors with 1-10% ER expression by immunohistochemistry (IHC). The clinical implications of ER-low positivity are incompletely understood, especially in invasive lobular carcinoma (ILC), the second most common type of breast cancer. Given the rarity of low-ER positivity in ILC, we evaluated tumor features and outcomes associated with a spectr

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Dalal, Bhavik, Takeshi Tada, Daxesh P. Patel, et al. "Abstract 1001: Urinary metabolite diagnostic and prognostic liquid biopsy biomarkers of lung cancer - never smokers versus tobacco smokers." Cancer Research 83, no. 7_Supplement (2023): 1001. http://dx.doi.org/10.1158/1538-7445.am2023-1001.

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Abstract Introduction: Never smokers account for 10-13% of all lung cancer cases in the United States. The etiology is attributed to multiple causes including exposure to passive smoking, parental smoking, asbestos and radon. However, these lung cancer cases do not fit the current United States Government-funded criterion of low-dose computed tomography that identifies early stages of lung cancer with higher survival following surgical removal. Methods: The cancer urinary biomarkers, creatine riboside (CR) and N-acetylneuraminic acid (NANA), were analyzed and quantified by liquid chromatograph

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Zhang, Wei, Merja Perälä, Roosa E. Kallionpää, et al. "Abstract 925: NTRK gene fusion in adults and pediatrics with solid tumors: a record linkage study of expression frequency and patient characteristics using the Auria Biobank in Finland." Cancer Research 83, no. 7_Supplement (2023): 925. http://dx.doi.org/10.1158/1538-7445.am2023-925.

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Abstract Introduction: Selective tropomyosin receptor kinase (TRK) inhibitors are targeted therapies for patients with solid tumors harboring a neurotrophic-receptor tyrosine kinase (NTRK) gene fusion. Estimates of the frequency of NTRK gene fusions and knowledge about characteristics of affected patients from population-based settings are limited. Methods: This was a retrospective cohort study using archival tissue samples from patients with histologically-confirmed solid tumors identified from the Auria Biobank in the Turku region of Finland (January 2005-December 2019). We evaluated all sol

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Matsumoto, Yoshiya, Tetsuya Watanabe, Megumi Mizutani, et al. "Abstract 2519: Alteration of tumor immune microenvironment after recurrence and its impact on the efficacy of anti-PD-1 antibody in resected non-small cell lung cancer patients." Cancer Research 84, no. 6_Supplement (2024): 2519. http://dx.doi.org/10.1158/1538-7445.am2024-2519.

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Abstract Background: Tumor immune microenvironment (TIME), including programmed death-1 ligand-1 (PD-L1) and CD8-positive tumor-infiltrating lymphocytes (TIL), has been suggested as a potential biomarker to predict the efficacy of anti-PD-1 antibody. Postoperative recurrence in patients with non-small cell lung cancer (NSCLC) is treated with therapeutic strategies similar to those for metastatic disease. However, in postoperative recurrence cases, PD-L1 evaluation is generally based on archival resection specimens, because there is little opportunity for a new biopsy of the recurrent site. The

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Shen, Sherry, Sara Myers, Yuan Chen, et al. "Abstract PO4-03-06: Body mass index and response to neoadjuvant chemo-immunotherapy among women with primary triple negative breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO4–03–06—PO4–03–06. http://dx.doi.org/10.1158/1538-7445.sabcs23-po4-03-06.

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Abstract Background: Elevated body mass index (BMI) is associated with lower rates of pathologic complete response (pCR) after neoadjuvant chemotherapy in patients with breast cancer. The addition of PD-1 receptor inhibition with pembrolizumab to neoadjuvant chemotherapy is now considered the standard of care for patients with stage II or III triple negative breast cancer (TNBC) based on results from the KEYNOTE-522 (KN-522) trial. In other cancer types such as melanoma and lung cancer, patients with overweight/obesity have better survival outcomes following treatment with immunotherapy compar

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Shao, Zhi-Ming, Da Pang, Hongjian Yang, et al. "Abstract PD18-03: Final analysis of the Phase III PEONY trial: long-term efficacy and safety of neoadjuvant–adjuvant pertuzumab or placebo, plus trastuzumab and docetaxel, in patients with HER2-positive early or locally advanced breast cancer." Cancer Research 83, no. 5_Supplement (2023): PD18–03—PD18–03. http://dx.doi.org/10.1158/1538-7445.sabcs22-pd18-03.

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Abstract BACKGROUND In the Phase II NeoSphere study (NCT00545688), dual HER2 blockade with pertuzumab (P) + trastuzumab (H), + docetaxel (D) significantly increased pathologic complete response (pCR) vs. H+D in the neoadjuvant setting for HER2-positive early breast cancer (EBC), locally advanced (LA) BC, or inflammatory BC, with supportive progression- and disease-free survival (DFS) data. Consistently, the randomized, multicenter, double-blind, placebo (Pla)-controlled Phase III PEONY trial (NCT02586025) significantly improved total pCR (tpCR; primary endpoint) with P+H+D vs. H+D in an Asian

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Kato, Kikuya, Mitsuaki Shirahata, Yoshitaka Narita, Yoshihiro Muragaki, Motohiko Maruno, and Ryo Matoba. "Validation of a gene expression-based diagnostic system for malignancy of glioma by multi-institute prospective-retrospective analysis." Journal of Clinical Oncology 31, no. 15_suppl (2013): 2066. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.2066.

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2066 Background: Histopathological classification of gliomas is often clinically inadequate due to the diversity of tumors that fall within the same class. Based on the strong correlation between malignancy and gene expression profile in gliomas, we constructed a diagnostic system based on gene expression profiling of 152 glioma samples (Shirahata et al., Cancer Sci, 2009, 100, 165). The diagnostic system was converted to that based on expression value of 27 genes measured with real-time PCR (Kawarazaki et al., BMC Med Genomics, 2010, 3, 52). Methods: First, the diagnostic system was validated

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Lacerda, Ana Forjaz, Graça Oliveira, Cândida Cancelinha, and Silvia Lopes. "Utilização do Internamento Hospitalar em Portugal Continental por Crianças com Doenças Crónicas Complexas (2011 – 2015)." Acta Médica Portuguesa 32, no. 7-8 (2019): 488. http://dx.doi.org/10.20344/amp.10437.

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Introduction: Due to epidemiological change, interest in complex chronic conditions has been increasing within the pediatric health system. As such, we aim to evaluate hospital inpatient care in the National Health Service (mainland Portugal) by pediatric patients (0 – 17 years) with complex chronic conditions.Material and Methods: Observational longitudinal retrospective epidemiological study using anonymized administrative data. We selected hospitalizations within the pediatric age limit, 2011 – 2015; healthy newborns and radiotherapy outpatients were excluded. A descriptive analysis of the

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Choong, Jamie, Monika M. Kutyna, Rakchha Chhetri, Sarah Moore, and Devendra Hiwase. "Frequency of Chromosomal Translocations Are Significantly Higher in Therapy Related Myeloid Neoplasm As Compared to Primary MDS." Blood 138, Supplement 1 (2021): 1532. http://dx.doi.org/10.1182/blood-2021-154523.

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Abstract Background: Myelodysplastic syndromes (MDS) are a heterogeneous group of disorders with variable outcomes. Acquired chromosome abnormalities in patients with myelodysplastic syndromes (MDS) are among the most valuable determinants of prognosis. However, chromosomal translocations are rare in MDS, and their prognostic implication is not well known. To elucidate factors driving chromosomal translocations in MDS, we compared the frequency of MDS patients with and without prior exposure to DNA damaging cytotoxic therapies. Methods: We evaluated diagnostic bone marrow metaphase cytogenetic

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Momen-Roknabadi, Amir, Mehran Karimzadeh, Nae-Chyun Chen, et al. "Abstract 7133: Detection of early stage colorectal cancer using cell-free oncRNA biomarkers and AI." Cancer Research 85, no. 8_Supplement_1 (2025): 7133. https://doi.org/10.1158/1538-7445.am2025-7133.

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Abstract Background: Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. Early detection offers the best opportunity for effective treatment. Although CRC screening methods exist, there remains a need for a high performing blood test to both improve adherence and detect early stage disease. We have previously identified and developed a novel category of cancer-associated, small orphan non-coding RNAs (oncRNAs), and combined them with generative AI modeling to develop a liquid biopsy platform. This platform has demonstrated high sensitivity and specificity

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Umanzor, Gerardo, Hope S. Rugo, Francisco J. Barrios, et al. "Abstract P1-16-05: Oraxol + Encequidar (OPac+E) vs IV paclitaxel (IVPac) in the treatment of patients with metastatic breast cancer (mBC) (Study KX-ORAX-001): Subgroup survival analysis of patients with hepatic dysfunction." Cancer Research 82, no. 4_Supplement (2022): P1–16–05—P1–16–05. http://dx.doi.org/10.1158/1538-7445.sabcs21-p1-16-05.

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Abstract Background: IVPac is widely used to treat patients with breast cancer. oPac+E is oral paclitaxel in combination with Encequidar, an oral, minimally absorbed, specific p-glycoprotein inhibitor that enables the absorption of oral paclitaxel. Results of the phase III trial, KX-ORAX-001, were presented at SABCS, 2019, Abstract # GS6-01. At the time of the database lock for the final analysis of the primary endpoint of confirmed tumor response rate, analyses of PFS and OS were performed. The confirmed tumor response rate was significantly higher in the oPac+E group vs IVPac (35.8% vs 23.4%

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Lee, Su Hyun, Han Suk Ryu, Myoung-jin Jang, Kyung-Hun Lee, and Han-Byoel Lee. "Abstract PO1-27-11: Survival Benefit of Adjuvant Endocrine Therapy in Patients with Estrogen Receptor Low-Positive Breast Cancer." Cancer Research 84, no. 9_Supplement (2024): PO1–27–11—PO1–27–11. http://dx.doi.org/10.1158/1538-7445.sabcs23-po1-27-11.

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Abstract Background: Estrogen receptor (ER) low-positive (1–10%) breast cancer is a very rare subtype that accounts for only 2–5% of all breast cancer cases and was introduced as a new category in the 2020 American Society of Clinical Oncology/College of American Pathologist Guidelines. There are limited data on the overall benefit of endocrine therapy for patients with ER low-positive cancers. The objective of this study was to analyze the clinicopathological characteristics and treatment patterns in patients with ER low-positive breast cancer and to compare disease-free survival (DFS) betwee

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White, Steven C. "New Audiology CPT Category III Codes." ASHA Leader 15, no. 3 (2010): 5. http://dx.doi.org/10.1044/leader.bml.15032010.5.

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Ahern, Michael J., and Geetha Chandran. "Category III Symptom-Modifying Antirheumatic Drugs." Clinical Immunotherapeutics 3, no. 3 (1995): 196–217. http://dx.doi.org/10.1007/bf03259056.

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COCKETT, ROBIN, and STEPHEN LACK. "Restriction categories III: colimits, partial limits and extensivity." Mathematical Structures in Computer Science 17, no. 4 (2007): 775–817. http://dx.doi.org/10.1017/s0960129507006056.

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A restriction category is an abstract formulation for a category of partial maps, defined in terms of certain specified idempotents called the restriction idempotents. All categories of partial maps are restriction categories; conversely, a restriction category is a category of partial maps if and only if the restriction idempotents split. Restriction categories facilitate reasoning about partial maps as they have a purely algebraic formulation.In this paper we consider colimits and limits in restriction categories. As the notion of restriction category is not self-dual, we should not expect c

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O'Donnell, Elizabeth K., Yael N. Shapiro, Amy Comander, et al. "Abstract PD5-11: Pilot study to assess prolonged nightly fasting in breast cancer survivors (LONGFAST)." Cancer Research 82, no. 4_Supplement (2022): PD5–11—PD5–11. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd5-11.

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Abstract Background: Prior, retrospective analysis of nightly fasting among women with breast cancer suggests that fasting less than 13 hours per night may be associated with higher risk of breast cancer recurrence. Small studies suggest that fasting duration can influence inflammation, obesity, sleep, and other potential mediators of breast cancer recurrence risk. Prolonged overnight fasting is a simple, nonpharmacological behavioral intervention strategy that may be doable for most patients. We designed this pilot study to prospectively evaluate the feasibility of prolonged overnight fasting

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Bajpai, Jyoti, Venkatesh Kapu, Sushmita Rath, et al. "Abstract RF01-08: A randomized, open-label phase III trial Evaluating Low-Dose Vs standard-dose Olanzapine with triple Antiemetic therapy for Prevention of highly emetogenic chemotherapy- induced Nausea and vomiting in solid tumors (OLAnzaPiNE)." Cancer Research 84, no. 9_Supplement (2024): RF01–08—RF01–08. http://dx.doi.org/10.1158/1538-7445.sabcs23-rf01-08.

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Abstract Background Chemotherapy induced nausea and vomiting (CINV) is a major adverse event for cancer patients. Olanzapine (OLZ) in standard 10 mg dose along with triple antiemetics (TAE), has shown effectiveness in treating CINV with highly emetogenic chemotherapy (HEC), however, significant day time somnolence (DTS) precludes its widespread use. Steroids related side effects are another major concern. Hence, a lower dose of OLZ, with single dose (SD) steroid use is worth exploring in a randomized fashion. Methods Solid tumors planned for anthracycline-cyclophosphamide & high-dose cispl

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Rozenblit, Mariya, Hao-Kuen Lin, Nhu Thuy Can, et al. "Abstract P2-23-14: Molecular characterization of HER2-low invasive breast carcinoma by quantitative RT-PCR using Oncotype DX®." Cancer Research 83, no. 5_Supplement (2023): P2–23–14—P2–23–14. http://dx.doi.org/10.1158/1538-7445.sabcs22-p2-23-14.

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Abstract Background: The DESTINY-Breast04 clinical trial demonstrated the superiority of trastuzumab deruxtecan (T-DXd) versus physician’s choice chemotherapy in HER2-low [immunohistochemistry (IHC) staining score 1+ or 2+ with no gene amplification by in-situ hybridization] metastatic breast cancer. The reproducibility of HER2 IHC category 0 versus 1+ scoring is poor in community practice. 89% of the DESTINY-04 participants were hormone receptor positive (HR+). In HR+ breast cancers, the Oncotype DX® (ODX) assay is widely used to estimate risk of recurrence and guide adjuvant chemotherapy sel

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Singh, Rishika, William Barlow, Nupur Singh, et al. "Abstract PO3-02-04: Comparison of OncotypeDX Recurrence Scores (RS) and MammaPrint (MP) scores, and chemotherapy indications in early-stage Estrogen Receptor positive/HER2 negative (ER-/HER2-) breast cancer." Cancer Research 84, no. 9_Supplement (2024): PO3–02–04—PO3–02–04. http://dx.doi.org/10.1158/1538-7445.sabcs23-po3-02-04.

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Abstract Background: Both RS and MP are endorsed by ASCO and NCCN practice guidelines to estimate prognosis of early-stage ER+/HER2- breast cancers and results guide adjuvant chemotherapy treatment recommendations. Earlier studies reported around 30% discordance in risk assignments by different genomic assays, but these comparisons were complicated by the 3-way (low, intermediate, high) versus 2-way (low, high) risk assignment by RS and MP respectively. More recently, RS thresholds were re-evaluated in the context of the TAILORx and RxPONDER randomized clinical trials and RS &gt;25 is now

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Megawati, Ruth, Wachju Subchan, Supeno, and I. Ketut Mahardika. "Project-Based Learning Model to Improve Students' Creativity in Biology Learning Media Courses Biology Education Study Program, Cenderawasih University." Jurnal Penelitian Pendidikan IPA 10, no. 10 (2024): 7243–49. http://dx.doi.org/10.29303/jppipa.v10i10.9128.

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The purpose of this study is to improve students' learning creativity through the application of the Project Based Learning (PjBL) learning model. This type of research is Classroom Action Research with four stages, namely planning, implementation, observation, and reflection. The research instrument uses observation sheets and learning outcome tests. Observations are carried out during learning, and learning outcome tests are given at the end of each cycle. Based on the results of the study, it was obtained in cycle 1 that the creativity indicator for fluent thinking was 37% in the less categ

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Celes, Aneeshya, and Hilda Fernandes. "Incidence and Malignancy Rate of Bethesda Category III Thyroid Lesions in A Tertiary Hospital." Annals of Pathology and Laboratory Medicine 7, no. 7 (2020): A332–335. http://dx.doi.org/10.21276/apalm.2719.

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Background: The introduction of The Bethesda System for Reporting Thyroid Cytopathology in 2010 provided the opportunity to establish worldwide standard reporting and terminology guidelines diagnostic category in reporting of thyroid FNAC. Indeterminate lesion included in the category III are those with insufficient degree of atypia to qualify for any of the suspicious categories. This study was conducted to determine the incidence and malignancy rate of Bethesda category III thyroid lesions. Methods: A two- and half-year retrospective study was conducted in Father muller medical college

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Mironov, V. G., I. K. Soldatov, P. A. Panevin, I. V. Mironov, P. S. Gushchin та A. V. Soldatova. "Retrospective analysis of professional hearing loss of Аir-space forces military personnel". Bulletin of the Russian Military Medical Academy 20, № 1 (2018): 75–77. http://dx.doi.org/10.17816/brmma12213.

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Research data on level and structure of sensorineural hearing loss among flight personnel who underwent medical and flight expertise for 2012-2016 is given. Among the analyzed evidences of the disease, 12,8% of military personnel have sensorineural hearing loss of varying degrees. The average age of the contingents tested was 42,1±0,5 years, however, the greatest number of cases occurred in the range of 40-44 years, with a flight time of 20,6±0,5 years in the study group. It was also revealed that bilateral hearing loss was observed in 72,28% cases, in 16,83% - left-sided and in 10,89% - right

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Chavez, Marianna, Jieling Miao, Lajos Pusztai, et al. "Abstract GS1-07: Results from a phase III randomized, placebo-controlled clinical trial evaluating adjuvant endocrine therapy +/- 1 year of everolimus in patients with high-risk hormone receptor-positive, HER2-negative breast cancer: SWOG S1207." Cancer Research 83, no. 5_Supplement (2023): GS1–07—GS1–07. http://dx.doi.org/10.1158/1538-7445.sabcs22-gs1-07.

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Abstract BACKGROUND: Abnormalities of the PI3kinase/AKT/mTOR signaling network are common in breast cancer (BC) and are associated with endocrine resistance. Everolimus, an mTOR-inhibitor increased PFS when combined with endocrine therapy (ET) in the metastatic setting and is thought to revert endocrine resistance. S1207 is a phase III randomized, placebo-controlled trial evaluating the role of everolimus in combination with ET in the adjuvant setting among patients with high-risk hormone receptor-positive, HER2-negative BC (NCT01674140). METHODS: Eligible patients were &gt;18 years of age

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Don, Sima, Nicole M. Verrills, Tracy Y. E. Liaw та ін. "Neuronal-associated microtubule proteins class III β-tubulin and MAP2c in neuroblastoma: Role in resistance to microtubule-targeted drugs". Molecular Cancer Therapeutics 3, № 9 (2004): 1137–46. http://dx.doi.org/10.1158/1535-7163.1137.3.9.

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Abstract Advanced stage neuroblastoma has a poor clinical outcome and microtubule-destabilizing agents, such as the Vinca alkaloids, are an important component in the treatment of this childhood cancer. Vinca alkaloids bind to β-tubulin on the α/β-tubulin heterodimer and disrupt microtubule dynamics, leading to cell death. To date, studies examining the contribution of microtubules and associated proteins to the efficacy of microtubule-destabilizing agents in neuroblastoma have been limited. In this study, BE(2)-C neuroblastoma cells previously selected for resistance to either vincristine (BE

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Knowles, Elena Lopez, Simone Detre, Margaret Hills, et al. "Abstract PD15-06: Estrogen receptor expression thresholds by IHC and mRNA for Ki67 response to aromatase inhibition: A POETIC study." Cancer Research 82, no. 4_Supplement (2022): PD15–06—PD15–06. http://dx.doi.org/10.1158/1538-7445.sabcs21-pd15-06.

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Abstract Background. Estrogen receptor (ER) expression is the key determinant for endocrine treatment of breast cancer (BC). In clinical practise ER analysis is currently almost entirely by immunohistochemistry (IHC). ASCO/CAP recommends cut-offs of &lt;1% (negative) and 1-10% (low) to minimise the risk of false negatives. There is uncertainty in the level of responsiveness of those with low ER. mRNA assessment could be acceptable or preferable if a similar or better threshold was shown to identify response to endocrine therapies. Change of Ki67 after 2 weeks’ presurgical treatment with ar

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Benardo, Larry S. "Excitatory Afferents to the Entorhinal Cortex Play a Role in Temporal Lobe Epileptogenesis." Epilepsy Currents 2, no. 1 (2002): 26–27. http://dx.doi.org/10.1111/j.1535-7597.2002.00010.x.

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Ibotenate Injections into the Pre- and Parasubiculum Provide Partial Protection Against Kainate-Induced Epileptic Damage in Layer III of Rat Entorhinal Cortex Eid T, Du F, Schwarcz R Epilepsia 2001;42:817–824 Purpose A loss of neurons in layer III of the entorhinal cortex (EC) is often observed in patients with temporal lobe epilepsy and in animal models of the disorder. We hypothesized that the susceptibility of layer III of the EC to prolonged seizure activity might be mediated by excitatory afferents originating in the presubiculum. Methods Experiments were designed to ablate the presubicul

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Таrashchenko, Yu M., А. E. Коvalenko, M. V. Оstafiychuk, et al. "Surgical treatment of the thyroid nodes of uncertain cytological structure." Klinicheskaia khirurgiia 86, no. 5 (2019): 59–63. http://dx.doi.org/10.26779/2522-1396.2019.05.59.

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Objective. To determine the clinical factors of the enhanced risk of malignancy in patients, having categories of cytological conclusions III (AUS/FLUS) and IV (FN/SFN). Маterials and methods. There were 11 621 patients examined with cytological investigation of thyroidal nodes under ultrasonographic control. Cytological conclusions of category ІІІ (AUS/FLUS) have characterized 621 nodes, while conclusions of category IV (FN/SFN) - 1215 nodes. There were operated 150 patients, owing cytological conclusions of category III, 436 patients - with cytological conclusions of category IV, and 1

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Frigeri, Cesare. "Category II and Category III Defects in 200 KEV Fe Implanted InP." Materials Science Forum 196-201 (November 1995): 1273–78. http://dx.doi.org/10.4028/www.scientific.net/msf.196-201.1273.

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Eka Sastrawati, Maryono, Yantoro, and Destrinelly. "Project based learning model in digital literacy course in education to improve creativity of pgsd unja students in writing scientific articles." Primary: Jurnal Pendidikan Guru Sekolah Dasar 14, no. 1 (2025): 1–10. https://doi.org/10.33578/jpfkip-v14i1.p1-10.

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This study aimed to improve students' creativity in writing scientific articles by applying the project-based Learning (PjBL) model. This type of research is classroom action research with four stages: planning, implementation, observation, and reflection. The research instrument used an observation sheet and a questionnaire for writing article creativity. Observations were carried out during learning, and a creativity questionnaire was given at the end of each cycle. Based on the study's results, it was obtained in cycle one that the indicator of fluent thinking creativity was 27% with a less

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Bredno, Joerg, Rita Shaknovich, Alexis Thornton, Susanne Tilk, Oliver Venn, and Chun Zhang. "Abstract 1947: Assessment of cancer subtypes across multiple cancer types using a circulating tumor DNA (ctDNA)-based targeted methylation assay." Cancer Research 85, no. 8_Supplement_1 (2025): 1947. https://doi.org/10.1158/1538-7445.am2025-1947.

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Background: Accurate identification of cancer subtypes is essential for effective diagnosis, prognosis, and treatment selection. Traditionally, histologic type, cell of origin, and underlying pathogenesis are determined using tissue histology, requiring invasive biopsies. This study evaluates the use of a ctDNA-based targeted methylation sequencing assay to identify cancer subtypes across multiple cancer types through a tissue-free blood test. Methods: Within the Circulating Cell-free Genome Atlas (CCGA, NCT02889978) study, clinical data were recorded and plasma samples processed using the tar

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