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Journal articles on the topic 'To 45.8(Category II)'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

HASSAN, SAMIA, MISBAH KAUSAR JAVAID, and SADIA TARIQ. "EMERGENCY CAESAREAN SECTION." Professional Medical Journal 15, no. 02 (2008): 211–15. http://dx.doi.org/10.29309/tpmj/2008.15.02.2772.

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Objective: Comparative analysis of problems encountered betweenpatients of elective caesarean section and patients for whom elective caesarean section was planned but ended upin emergency caesarean section. Design: Descriptive prospective analysis. Setting: Gynae Unit-II, Services Hospital,Lahore. Duration: One year, 1 January 2006 to 31 December 2006. Patients & Methods: A prospective study of st st100 patients who presented for antenatal care (ANC) and for whom elective caesarean section (CS) was planned wasdone. Patients evaluation was done on a designed performa that included demograph

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Aman, Kishor, Kumar Jwala, Ranjan Shrivastava Manish, and Anwar Zaman Zaki. "A Comparative Study of the Efficacy and Safety of 5% Minoxidil and 1 Mg Finasteride in Male Androgenetic Alopecia Patients at a Tertiary Centre in Bihar." International Journal of Pharmaceutical and Clinical Research 15, no. 5 (2023): 1982–88. https://doi.org/10.5281/zenodo.12607392.

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<strong>Background: </strong>Androgenetic alopecia (AGA) is responsible for 95% of hair loss in males over 50. However, AGA is far less frequent in women, with around 40% of women experiencing some degree of hair loss, particularly after menopause. In a gradual process, alopecia is caused by the 5-reductase enzyme converting testosterone to dihydrotestosterone (DHT), which causes hair follicles to shrink. <strong>Aims and Objectives: </strong>A comparative study of the efficacy and safety of 5% minoxidil and 1 mg finasteride in male androgenetic alopecia patients. <strong>M

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Ulyanov, M. V., and M. I. Fomichev. "Research of Features of the Combined Algorithm for Solving the Asymmetric Traveling Salesman Problem." INFORMACIONNYE TEHNOLOGII 27, no. 1 (2021): 3–8. http://dx.doi.org/10.17587/it.27.3-8.

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The exact algorithm that implements the Branch and Boimd method with precomputed tour which is calculated by Lin-Kernighan-Helsgaun metaheuristic algorithm for solving the Traveling Salesman Problem is concerned here. Reducing the number of decision tree nodes, which are created by the Branches and Bound method, due to a "good" precomputed tour leads to the classical balancing dilemma of time costs. A tour that is close to optimal one takes time, even when the Lin-Kernighan-Helsgaun algorithm is used, however it reduces the working time of the Branch and Bound method. The problem of determinin

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Natalina, Riny, and Legawati Legawati. "PEMBERIAN DAN DEMONSTRASI PENGOLAHAN JUS BAYAM MERAH UNTUK IBU HAMIL TRIMESTER I DAN II DENGAN ANEMIA DI PUSKESMAS BUKIT RAWI." EJOIN : Jurnal Pengabdian Masyarakat 2, no. 1 (2024): 74–78. http://dx.doi.org/10.55681/ejoin.v2i1.2168.

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Anemia is caused due to iron deficiency caused by physiological changes due to pregnancy that are aggravated by a state of lack of nutrients, vitamin B12, folic acid and vitamin C. The goal is to increase the ability of pregnant women in making red spinach juice and increase HB levels of third trimester pregnant women with anemia with consumption of red spinach juice. Method of activity: Pregnant women involved a total of 20 pregnant women and previously checked the Hb levels of pregnant women before being given red spinach juice, followed by a demo of making red spinach juice. After 14 days,

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Faisal, Muhammad. "ANALISIS RISIKO PADA TAHAP PELAKSANAAN KONSTRUKSI JALAN TOL CINERE – JAGORAWI, DEPOK." Jurnal Proyek Teknik Sipil 4, no. 1 (2021): 33–42. http://dx.doi.org/10.14710/potensi.2021.10424.

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Cinere-Jagorawi Toll Road is a part of Jakarta Outer Ring Road (JORR) II which has the total length of 110 kilometer that circle around Seokarta-Hatta International Airport until Tanjung Priok. By the existance of JORR II, there would be an easy access from seaport to airport and vice versa. This also would be streamlining traffic flow from west to east considering the traffic at JORR I has overused which could cause congestion. In every construction of the Toll Road, there would be some risks that possibly arise. To minimize the risks that could occur, identification, anlysis, mitigation and

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Irawan, Fajar Awang, Sutaryono Sutaryono, Dhias Fajar Widya Permana, Long-Ren Chuang, and Yuwono Yuwono. "Locomotor Skills: Traditional Games in the Fundamental of Physical Activities." Al-Athfaal: Jurnal Ilmiah Pendidikan Anak Usia Dini 4, no. 1 (2021): 1–13. http://dx.doi.org/10.24042/ajipaud.v4i1.8215.

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Motor coordination will be hampered if the stimulation of children's movement development tends to be neglected. This will have an impact on the child's movement skills. The purpose of this study was to determine traditional games in basic physical activities using locomotor skills. This study uses Classroom Action Research (PTK) which aims to see how much increase in the application of traditional games. The research was conducted at Madrasah Ibtidaiyah Lerep Ungaran Barat and this study used male students aged 7-9 years. There were 18 children who followed and participated in traditional gam

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Abdi, Tenri Risna. "Karakteristik Pasien Hipertensi di Puskesmas Tabaringan Makassar." Indonesian Journal of Health 1, no. 02 (2021): 112–19. http://dx.doi.org/10.33368/inajoh.v1i02.24.

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Hypertension is a condition in which systolic blood pressure (TDS) ≥ 140 mmHg or diastolic blood pressure (TDD) ≥ 90 mmHg that measured by health personnel at least two times. The research objective is to describe the characteristics of hypertensive patients at Tabaringan Health Center. The characteristics referred to gender,age, BMI, and hypertension degree. This research used a descriptive research method by using an observational approach to describe the characteristics of hypertensive patients. The results showed that the total number of male patients with hypertension was 34 (44.7%) and f

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Adpriyadi, Adpriyadi. "Peningkatan kemampuan motorik kasar melalui permainan tradisional Engklek pada anak kelompok B." JPPM (Jurnal Pendidikan dan Pemberdayaan Masyarakat) 4, no. 2 (2017): 187–98. http://dx.doi.org/10.21831/jppm.v4i2.10016.

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Penelitian ini bertujuan untuk memperbaiki proses dan hasil pembelajaran sebagai upaya meningkatkan kemampuan motorik kasar anak kelompok B di TK Tunas Gading Yogyakarta. Jenis penelitian ini adalah penelitian tindakan kelas yang dilakukan dalam III siklus, subjek dalam penelitian ini adalah anak didik kelompok B TK Tunas Gading Yogyakarta tahun ajaran 2015/2016 yang berjumlah 16 anak yang terdiri dari 7 laki-laki dan 9 perempuan. Pengumpulan data dilakukan melalui unjuk kerja, Observasi dan dokumentasi. Teknik analisis data di lakukan dengan menggunakan statistik deskriptif sederhana, data di

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Ichord, Rebecca, Faye S. Silverstein, Beth S. Slomine, et al. "Neurologic outcomes in pediatric cardiac arrest survivors enrolled in the THAPCA trials." Neurology 91, no. 2 (2018): e123-e131. http://dx.doi.org/10.1212/wnl.0000000000005773.

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ObjectiveTo implement a standardized approach to characterize neurologic outcomes among 12-month survivors in the Therapeutic Hypothermia after Pediatric Cardiac Arrest (THAPCA) trials.MethodsTwo multicenter trials enrolled children age 48 hours to 18 years who remained comatose after cardiac arrest (CA) occurring out-of-hospital (THAPCA-OH, NCT00878644) or in-hospital (THAPCA-IH, NCT00880087); patients were randomized to therapeutic hypothermia or therapeutic normothermia. The primary outcome, survival with favorable 12-month neurobehavioral outcome (Vineland Adaptive Behavior Scales [VABS-II

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Blaginina, I. I. "Complex therapy for patients with ankylosing spondylitis with mixed anxiety–depressive disorder." Medical Herald of the South of Russia 12, no. 1 (2021): 38–45. http://dx.doi.org/10.21886/2219-8075-2021-12-1-38-45.

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Objective. The study aimed to evaluate the effect of therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) in combination with melatonin on the dynamics of the quality of life (QOL), clinical and laboratory activity, and mixed anxiety– depressive disorder (MADD) in patients with ankylosing spondylitis (AS).Materials and methods. The study involved 65 patients with AS and RTDS. Patients from Group I (n=32) were prescribed melatonin at a dose of 3 mg per day at night, 30–40 minutes before bedtime, in addition to standard AS therapy. Patients from Group II (n = 33) received standard therapy.

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Boychuk, Alla V., Natalia V. Kotsabyn, Julia B. Yakymchuk, and Iryna M. Nikitina. "Pregravid preparation of women with chronic endometritis in IVF cycles." Wiadomości Lekarskie 77, no. 1 (2024): 25–28. http://dx.doi.org/10.36740/wlek202401103.

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Aim: of our study was to improve the pregravid preparation of women with chronic endometritis to develop individual approaches to overcoming infertility, taking into account the state of endometrium. Materials and Methods: The study included 90 women (main group, n=90), 28 to 38 years with an anatomically normal uterus and chronic endometritis (CE). Patients were divided into 2 groups: group I – 45 women with CE who received conventional treatment; group II – 45 women with CE who received pregravid preparation by subendometrial injections of Platelet-Rich Plasma (PRP). Results: At the first st

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Citrome, Leslie, Robert Goldman, Joyce Tsai, Ling Deng, Todd Grinnell, and Andrei Pikalov. "168 Effect of Dasotraline on Body Weight in Patients with Binge-Eating Disorder." CNS Spectrums 25, no. 2 (2020): 307. http://dx.doi.org/10.1017/s109285292000084x.

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Abstract:Background:Binge-eating disorder (BED) is associated with obesity (BMI ≥30) in approximately 40-45% of patients. Dasotraline is a long-acting dopamine/norepinephrine reuptake inhibitor with a PK profile characterized by slow absorption and an elimination half-life of 47-77 hours, permitting once-daily dosing. In a recent placebo-controlled, flexible-dose study, dasotraline demonstrated significant efficacy in patients with BED. We now report an analysis from this study of the effect of dasotraline on body weight.Method:Patients with moderate-to-severe BED, based on DSM-5 criteria, wer

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Guy, Lisette, Sean Gorman, Jennifer Wilson, et al. "#3031 Outcome and evaluation of an outpatient multidisciplinary group-based rehabilitative therapy programme for functional neurological disorder." Journal of Neurology, Neurosurgery & Psychiatry 92, no. 8 (2021): A12.2—A12. http://dx.doi.org/10.1136/jnnp-2021-bnpa.29.

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AimsWe report findings from an eight-week rehabilitative therapy programme, delivered in a neuropsychiatric outpatient setting, with co-primary aims to (1) reduce symptom severity, and (2) improve functional mobility, in selected adults with a diagnosis of Functional Neurological Disorder (FND). Effectiveness of the programme was assessed in regard to outcome data routinely collected throughout the programme, and at three-month follow-up.MethodFollowing appropriate referral, criteria screening and initial assessment, suitable individuals attended as day patients for two days per week over an e

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Rice, Kevin R., Martin J. Magers, Stephen Beck, Lawrence H. Einhorn, Thomas M. Ulbright, and Richard Foster. "Aggressive surgical management of germ cell tumors with somatic-type malignancy: Pathologic features, prognostic factors, and survival outcomes." Journal of Clinical Oncology 31, no. 15_suppl (2013): 4554. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.4554.

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4554 Background: Germ cell tumors (GCT) with somatic-type malignancy (SM) are rare occurring in approximately 3-8% of GCT cases. Prognostic factors and optimal management remain poorly-defined. Methods: The Indiana University (IU) testis cancer database was queried from 1979 to 2011 for patients demonstrating atypical histology at orchiectomy or subsequent resection of metastatic disease. Patients with transformation to PNET only were excluded due to distinct management. Chart review, pathologic review, and survival analysis were performed. Results: 122 patients met study inclusion criteria. P

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FEDORCHUK, A. "Analysis of erypsoidal heights errors based on GNSS-leveling results." Modern achievements of geodesic science and industry 41, no. I (2021): 37–45. http://dx.doi.org/10.33841/1819-1339-1-41-37-45.

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Research the influence of errors on the measurement results is always an urgent task. Analysis of such values makes it possible to assess the nature of the change and the magnitude of the impact of errors for their further consideration or compensation, or minimization. In this paper, the errors in determining ellipsoidal heights from GNSS observations are considered. In determining the ellipsoidal heights, this method can achieve an accuracy of 1–2 cm in static mode (Static) and 2–4 cm in real time mode (RTK). Thus, the accuracy of the chosen mode of observations will indicate the initial lim

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Tanjung, Asbar, Ika Nurhidayah, Sharfina Maulidayanti, and Ing Mayfa Br Situmorang. "Analysis of Serum Creatinine Levels, Blood Pressure and Grade of Hypertension of Chronic Disease Management Program Participants." Medical Laboratory Technology Journal 10, no. 2 (2025): 143–51. https://doi.org/10.31964/mltj.v10i2.619.

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Indonesia is one of the countries with the highest number of cases of hypertension in the world; the predominant patient is the elderly. In some patients with hypertension, increased blood pressure causes impaired salt and creatinine excretion, resulting in poor kidney function. A chronic disease management program is a health care system with a proactive-integrative approach to prevent further complications. The research objective is to analyze serum creatinine levels, blood pressure, and hypertension grade and determine the relationship between serum creatinine and blood pressure in chronic

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Awad, Ramez Heshmat, Seshan Subramanian, and Carlos f. Garcia. "Are We Doing Too Many HIT Tests? II." Blood 126, no. 23 (2015): 2310. http://dx.doi.org/10.1182/blood.v126.23.2310.2310.

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Abstract Back Ground: Heparin Induced Thrombocytopenia is a complex immune disorder related to exposure to heparin that results in arterial and venous thrombosis and moderate to severe thrombocytopenia. Incidence is 0.8-1% in hospitalized patients exposed to heparin. However there is a problem with over testing for HIT syndrome that it is not only financially burdensome but that treating false positive patients with anticoagulation can increase their risk for bleeding. Objective: To determine the actual incidence of Type II-HIT compared to the frequency and necessity of testing in a single urb

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Mudib, Mudib, Kristanto Yuli Yarso, and Henky Agung Nugroho. "Age as an Independent Factor in the Permanent Chemotherapy-Induced Amenorrhea Incidence in Breast Cancer Patients at Dr. Moewardi Hospital, Surakarta, Indonesia." Open Access Macedonian Journal of Medical Sciences 9, B (2021): 816–20. http://dx.doi.org/10.3889/oamjms.2021.6712.

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Background: Chemotherapy Induced Amenorrhea (CIA) is one common side effect of chemotherapy in breast cancer patients. Some who have CIA may experience menstruation return while others experience permanent CIA. Aim: to examines the factors that contribute to the incidence of persistent CIA in breast cancer patients. Methods: The population of this retrospective study was new breast cancer patients with premenopausal status when they started receiving chemotherapy at dr Moewardi Hospital Surakarta, Indonesia, from January 2019 to July 2021. To determine the relationship, the chi-squ

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Robert, Caroline, Céleste Lebbé, Sevrine Ricard, et al. "Personal melanoma risk awareness versus intrinsic risk." Journal of Clinical Oncology 31, no. 15_suppl (2013): 9069. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.9069.

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9069 Background: Intrinsic risk factors for melanoma include personal and family history of the condition, a high number of naevi and a light skin phototype (I or II). The objective of this study was to evaluate the correlation between personal awareness of melanoma risk and objective risk factors and to analyze the elements associated with under-or over-evaluation of the actual risk. Methods: EDIFICE melanoma, a nationwide French observational survey, was conducted through phone interviews on a representative sample of 1502 subjects aged ≥ 18 using typical quotas. The survey took place from 2

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Dantey, Kossivi, Farhad Hasan, Ali Tipu, and Tanvi Verma. "ODP481 Frequency and outcomes of reporting Bethesda class III thyroid cytopathology- An integrated health network's experience." Journal of the Endocrine Society 6, Supplement_1 (2022): A766. http://dx.doi.org/10.1210/jendso/bvac150.1581.

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Abstract Introduction Indeterminate thyroid nodule cytologic diagnosis causes anxiety and confusion to the patient and typically results in additional intervention including thyroid surgery. This increases risk of harm and cost of healthcare. The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) recommends that cytologists attempt to limit reporting 'indeterminate' [Bethesda III (B-III)] category when interpreting thyroid fine needle aspiration (FNA) specimens, and that all effort be made to limit this diagnosis to less or equal to 7% of all thyroid FNA cases. B-III encompasses foll

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Barandiaran, JV, TC Hall, I. Glaves, N. El-Barghouti, and EP Perry. "An observational study into the management of arteriomegaly: a call for a revised classification system." Annals of The Royal College of Surgeons of England 94, no. 4 (2012): 250–55. http://dx.doi.org/10.1308/003588412x13171221498505.

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INTRODUCTION Arteriomegaly is the diffuse ectasia of arteries with or without aneurysmal disease. Patients with arteriomegaly have a higher incidence of morbidity including limb loss compared to patients with other arteriopathies. The aim of this observational study was to review the management of these patients in our institution. METHODS Radiologists and surgeons prospectively reviewed aortofemoral angiography. Patients with arteriomegaly were identified. Data relating to demographics, mode of presentation, risk factors, type of arteriomegaly, management and progression of disease were analy

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Salvi, Flavia, Daniela Gioia, Maria Teresa Corsetti, et al. "Phase II Multicenter Study of Association of Arsenic Trioxide (ATO) and Ascorbic Acid in Myelodysplastic Syndrome." Blood 114, no. 22 (2009): 943. http://dx.doi.org/10.1182/blood.v114.22.943.943.

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Abstract Abstract 943 Introduction: Arsenic trioxide (ATO) inhibits angiogenesis, induces apoptosis and differentiation in variety of malignant cells. Two multicenter phase II studies have documented that ATO has as a moderate activity both in low and high risk myelodysplasia with 19-21% haematological improvement. Ascorbic acid in “vitro” increases in tumor cells the activity of ATO by depleting GSH and inhibiting NF-kb. High EVI-1 levels have been reported to predicted the response to arsenic trioxide and thalidomide combination therapy. We report the results of a multicenter phase II study

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Pruitt, Margaret, Rajesh Naidu Janapala, and Faysal Haroun. "Patterns of lung cancer in people living with human immunodeficiency virus (HIV): A retrospective, single-center study in Washington, D.C." Journal of Clinical Oncology 39, no. 15_suppl (2021): e21154-e21154. http://dx.doi.org/10.1200/jco.2021.39.15_suppl.e21154.

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e21154 Background: Lung cancer is the leading cause of cancer death and the most common non-acquired immune deficiency syndrome defining malignancy in people living with HIV (PLWH). Disparities in outcomes have been observed despite lung cancer mortality reportedly decreasing in the general population over the last decade due to lower rates of smoking and the advent of novel therapies. To better understand the current trend in lung cancer in PLWH, we explored demographic characteristics, comorbidities, and lung cancer pathology and molecular data in this population. Methods: A retrospective se

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Kroeger, Nicolaus, Tatjana Zabelina, Thomas Binder, et al. "Comparable Results of HLA-Mismatched Vs HLA-Matched Unrelated Donors for Allogeneic Stem Cell Transplantation Using Pre-Transplant ATG." Blood 112, no. 11 (2008): 966. http://dx.doi.org/10.1182/blood.v112.11.966.966.

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Abstract For patients lacking an HLA-identical sibling, more than ten million unrelated donor (UD) are available for donation of hematopoietic stem cells. Despite this increasing number of UD, up to 30 % of the patients will not find a completely-HLA-matched donor. HLAmismatched unrelated stem cell transplantation (SCT) is associated with an increased risk of acute and chronic graft-versus-host disease and a higher transplant-related mortality resulting in a lower survival after allogeneic SCT. We analyzed on outcome of allele- and antigen-mismatch SCT from UD using pre-transplantation anti-th

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Nestler, Tim, Justine Schoch, Viola Düring, et al. "Influence of MRIs performed in a 6-week interval on the histopathological detection of prostate cancer with different PIRADS classifications: A real-world data analysis." Journal of Clinical Oncology 43, no. 5_suppl (2025): 334. https://doi.org/10.1200/jco.2025.43.5_suppl.334.

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334 Background: In the early phases of MRI-guided prostate biopsies, it was often necessary to perform an additional in-house multiparametric MRI after an external MRI to accurately assess lesions for biopsy. This study aims to evaluate the consistency of lesion identification and the associated clinical and histological outcomes at a high-volume tertiary care center performing over 500 biopsies annually. Methods: This analysis included real-world data from 111 patients treated between 2018 and 2022. Each patient underwent two multiparametric MRI scans of the prostate at different institutions

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Mark, Tomer M., Sujitha Yadlapati, Lyubov Neglyad, et al. "High-Dose Carfilzomib and Dexamethasone As First-Line Treatment in Symptomatic Multiple Myeloma." Blood 126, no. 23 (2015): 4258. http://dx.doi.org/10.1182/blood.v126.23.4258.4258.

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Abstract Background: Carfilzomib (Cfz) is approved for use in relapsed and refractory multiple myeloma (RRMM) at a dose of 27mg/m2 after escalation from 20mg/m2. The response rate for Cfz and dexamethasone (dex) as first-line therapy in multiple myeloma (MM) is unknown. Higher doses of Cfz have been shown to enhance overall response in RRMM (Lendvai 2014); the presence of a dose-response relationship of Cfz for first-line therapy in untreated MM has not been evaluated. A protocol of Cfz-Dex induction at two dosing levels, followed by BiRd (Clarithromycin 500mg PO BID, Lenalidomide (Len) 25mg f

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Liebman, Howard A., Mansoor N. Saleh, James B. Bussel, et al. "Phase I/II Study of Monotherapy with Subcutaneous Injections of Low-Dose Anti-CD20 Veltuzumab in Relapsed Immune Thrombocytopenia." Blood 120, no. 21 (2012): 622. http://dx.doi.org/10.1182/blood.v120.21.622.622.

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Abstract Abstract 622 Background: Veltuzumab is a 2nd-generation humanized anti-CD20 monoclonal antibody with structure-function differences from rituximab, and evidence of higher potency preclinically (Goldenberg et al., Blood. 113(5):1062–70, 2008). In non-Hodgkin lymphoma (NHL), subcutaneous (SC) injections of low-dose veltuzumab were well-tolerated and demonstrated high activity (Negrea et al., Haematologica. 96:567–73, 2011), comparable to that achieved by intravenous infusions (Morschhauser et al., J Clin Oncol. 2009;27:3346–53). As such, we postulated that low-dose SC veltuzumab also ma

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Taybi, Mahat, Zineb Khammar, Noufissa Alami Drideb, et al. "Molecular Classification of Large B-Cell Lymphoma and High-Grade B-Cell Lymphoma Cases and Association with Outcomes in Morocco." Hemato 5, no. 4 (2024): 396–406. http://dx.doi.org/10.3390/hemato5040029.

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Background: High-grade B-cell lymphoma with c-MYC and BCL2 and/or BCL6 rearrangements (HGBL-DHL/THL) is a recently identified category in the most recent World Health Organization (WHO) classification. For all tumors displaying the appearance of diffuse large B-cell lymphoma (DLBCL) or high-grade B-cell lymphoma (HGBL), it is necessary to perform fluorescence in situ hybridization (FISH) in order to achieve an accurate diagnosis. The findings of FISH and immunohistochemistry (IHC) examinations from 50 DLBCL/HGBL samples obtained from Hassan II University Hospital in Fez/Morocco are reported. M

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Giona, Fiorina, Angela Amendola, Giovanna Palumbo, et al. "Inherited and Acquired Thrombophilic Abnormalities in Patients Aged <20 Years with Bcr-Abl Negative Chronic Myeloproliferative Disorders." Blood 112, no. 11 (2008): 5249. http://dx.doi.org/10.1182/blood.v112.11.5249.5249.

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Abstract Several associated thrombophilic abnormalities have been reported in adults with Bcr-Abl negative chronic myeloproliferative disorders (CMD), mostly in essential thrombocythemia (ET) and polycythemia vera (PV), while only sporadic data are available in younger patients (pts). In order to identify coagulation abnormalities in very young pts with a diagnosis of CMD, we evaluated different thrombophilic parameters in CMD pts aged &lt;20 years (yrs) at the time of diagnosis. Lupus anticoagulant (KCT and dRVVT), functional protein C (PC), free protein S (PS) antigen, functional antithr

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Gisslinger, Heinz, Veronika Buxhofer-Ausch, Josef Thaler, et al. "Efficacy and Safety Of AOP2014/P1101, a Novel, Investigational Mono-Pegylated Proline-Interferon Alpha-2b, In Patients With Polycythemia Vera (PV): Update On 51 Patients From The Ongoing Phase I/II Peginvera Study." Blood 122, no. 21 (2013): 4046. http://dx.doi.org/10.1182/blood.v122.21.4046.4046.

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Abstract Background AOP2014/P1101 is a novel, investigational mono-pegylated proline-interferon alpha-2b. In contrast to other pegylated IFNs, AOP2014/P1101 consists of one predominant isoform. AOP2014/P1101 has Orphan Drug Designation in EU and USA for treatment of patients with PV. Study design Long term efficacy and safety data are being collected in the follow-up extension stage of the study (collecting the data of both Phase I and Phase II portions of the study), after the maximum tolerated dose (MTD) of AOP2014, administered subcutaneously every 14 days, has been defined earlier. Patient

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Lugtenburg, Pieternella J., Josée M. Zijlstra, Jeanette K. Doorduijn, et al. "Rituximab-PECC Induction Followed by 90y-Ibritumomab Tiuxetan Consolidation in Relapsed or Refractory DLBCL Patients Who Are Not Eligible for or After ASCT: Preliminary Results From a Phase II HOVON Study." Blood 120, no. 21 (2012): 2729. http://dx.doi.org/10.1182/blood.v120.21.2729.2729.

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Abstract Abstract 2729 Background. Patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) after- or not eligible for autologous stem cell transplantation (ASCT) have a poor prognosis. The optimum salvage therapy for these patients is not known. Treatment results with second-line chemotherapy have generally been disappointing. In some centers in the Netherlands PECC (Prednisone, Etoposide, Chlorambucil and Lomustine) combination chemotherapy is used as salvage treatment for such patients. PECC is a completely oral schedule. The efficacy and toxicity of PECC in this patient c

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Jimenez Zepeda, Victor H., Peter Duggan, Paola E. Neri, and Nizar J. Bahlis. "Cyclophosphamide, Bortezomib and Dexamethasone (CyBORD) Is a Feasible and Active Regimen for Non-Transplant Eligible Multiple Myeloma Patients." Blood 124, no. 21 (2014): 5751. http://dx.doi.org/10.1182/blood.v124.21.5751.5751.

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Abstract Introduction With the advent of novel drugs for the treatment of Multiple Myeloma (MM), the clinical outcomes have significantly improved over the last decade both in the setting of stem cell transplant eligible and non-eligible patients. Combinations of novel drugs have improved and deepened response and this is true for CyBORD, a regimen able to induce rapid and deep responses. Based on the above mentioned, we aimed to assess the role and feasibility of CyBORD as upfront therapy for non-transplant eligible patients with MM. Methods. All consecutive patients with documented symptomat

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Nair, Vidhu V., Sobha S. Nair, and Prasanna Venugopalan. "Decision to delivery interval in emergency LSCS and its impact on fetal outcome." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 8, no. 9 (2019): 3679. http://dx.doi.org/10.18203/2320-1770.ijrcog20193797.

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Background: Emergency LSCS can be categorized based on RCOG guidelines into category I and II which indicates maternal or fetal compromise. Here an urgent delivery and the DDI (decision to delivery interval) within 30 and 45 minutes respectively is needed.Methods: This is a retrospective cross-sectional analysis conducted on a sample of 630 patients who underwent caesarean section over a year, from June 2016 to June 2017. The DDI were further classified into ≤30 and >30 minutes for category I, ≤45 and >45 minutes for category II LSCS. The primary objective is to determine whether DDI in

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Patch, David A., James T. McMurtrie, Mason Frazier, et al. "Union Rates of Talar Neck Fractures with Critical Bone Defects Treated with Autograft." Foot & Ankle Orthopaedics 7, no. 1 (2022): 2473011421S0039. http://dx.doi.org/10.1177/2473011421s00392.

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Category: Trauma Introduction/Purpose: The purpose of this study was to evaluate union of talar neck fractures with critical bone defects treated acutely with autologous tibial bone graft during primary osteosynthesis. We hypothesized that acute autografting leads to reliable union rates. Methods: A case series at a Level I trauma center was performed to identify patients who underwent open reduction and internal fixation of talar neck fracture with proximal tibial autograft between 2015 and 2018. Inclusion criteria were age greater than 18 years and displaced talar neck fracture with critical

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Bowen, Kristina E., James W. Gilmore, Stephen Szabo, et al. "Evaluation of variables that may impact chemotherapy (CT) administration after determination of Oncotype DX (ODX) recurrence score (RS)." Journal of Clinical Oncology 30, no. 15_suppl (2012): 571. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.571.

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571 Background: Cardinal Health Specialty Solutions (CHSS) partners with payers to manage clinical care pathways in oncology and rheumatology. Observations from one such pathway with CareFirst BlueCross Blue Shield revealed lower than expected use of CT in patients (pts) with estrogen receptor-positive early-stage breast cancer (ESBC) at high-risk for recurrence by ODX RS. To better understand physician behavior, CHSS examined patterns of care in a large private practice oncology group with a robust EMR, Georgia Cancer Specialists (GCS). Pt characteristics and physician-prescribing patterns we

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Ferreri, Andres JM, Teresa Calimeri, Gian Marco Conte, et al. "R-CHOP Preceded By Engineered Tumor Necrosis Factor (TNF) in Patients with Relapsed or Refractory (r/r) Primary CNS Lymphoma (PCNSL): Results of Antitumor Activity, Safety and Blood-Brain Barrier (BBB) Permeabilization in the "Ingrid" Phase II Trial." Blood 132, Supplement 1 (2018): 1687. http://dx.doi.org/10.1182/blood-2018-99-118507.

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Abstract Background: Almost all PCNSL belong to the category of DLBCL. However, affected pts are treated with high-dose methotrexate-based combinations that are not currently used in other DLBCL and require hospitalization and extensive expertise to manage toxicity. The use of R-CHOP could overcome these difficulties, but CNS availability of related drugs is poor. TNF induces BBB permeabilization and enhances CNS access of anticancer drugs. Coupling TNF with NGR, a peptide that targets CD13+ tumor vessels, improves its biological effects and therapeutic index. Thus, we tested the hypothesis th

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Gangat, Naseema, Terra L. Lasho, Mrinal M. Patnaik, et al. "ASXL1 Mutations in Myelodysplastic Syndromes with 1% or More Ring Sideroblasts: Prevalence, Clinical Correlates and Prognostic Relevance." Blood 126, no. 23 (2015): 2882. http://dx.doi.org/10.1182/blood.v126.23.2882.2882.

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Abstract Background: Addition of sex combs-like 1 (ASXL1) is frequently mutated (mutational frequency 14-29%) and is prognostically relevant in myelodysplastic syndromes (MDS) (Bejar, NEJM 2011, Thol, JCO 2011). The prevalence and prognostic impact of ASXL1 mutation in MDS with ring sideroblasts (MDS-RS) is not known. MDS-RS is defined by the presence of ≥15% RS in bone marrow (BM), with refractory anemia with ring sideroblasts (RARS) being the prototype but may also be seen in other categories. Methods : Our institutional database was reviewed to identify patients with WHO-defined primary MDS

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Shim, Youn K., Jane Rachel, Paolo Ghia, et al. "Monoclonal B-Cell Lymphocytosis (MBL) in Blood Donors: Age- and Sex-Specific Prevalence, Clone Size, and IGHV-IGHD-IGHJ Rearrangements." Blood 118, no. 21 (2011): 2840. http://dx.doi.org/10.1182/blood.v118.21.2840.2840.

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Abstract Abstract 2840 Recent studies using sensitive flow cytometry methods have reported up to 14% MBL prevalence among older adults. Although MBL has been detected in donated blood, a systematic study of MBL prevalence in blood donors is lacking. We initiated the first such study, using high sensitivity immunophenotyping and ensuring exclusion of repeat donors. Here we report results from the first ten months. Starting in May 2010, samples from 1090 blood donors over 44 years old were collected at a regional U.S. blood center. Samples were immunophenotyped by flow cytometry with a six-color

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Eder, Sandra, Myriam Labopin, Jurgen Finke, et al. "Safety and Efficacy of Thiotepa-Based Conditioning Therapy for Allogeneic Transplantation in Acute Myeloid Leukemia - a Survey from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation." Blood 124, no. 21 (2014): 3895. http://dx.doi.org/10.1182/blood.v124.21.3895.3895.

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Abstract Background Thiotepa (TTP) is an alkylating compound with an antineoplastic activity that has been used since the early nineties. However, few studies focused on the analysis of the benefit of TTP in the pre-allogeneic hematopoietic stem cell transplantation (HSCT) conditioning in a specific disease category. Beside its antineoplastic activity, TTP has immunosuppressive properties and the ability to penetrate the blood-brain barrier in conjunction with a good toxicity profile that makes it an attractive compound to use in the transplant setting. Therefore, the aim of the current analys

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Lim, Jung-Won, and Hong-Geun Jung. "The Radiographic Support for Distal Tibia Medial Opening-Wedge Osteotomy with Fibular Valgization Osteotomy for Medial Ankle Osteoarthritis." Foot & Ankle Orthopaedics 5, no. 4 (2020): 2473011420S0033. http://dx.doi.org/10.1177/2473011420s00332.

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Category: Ankle; Ankle Arthritis Introduction/Purpose: Supramalleolar osteotomy (SMO) has recently been accepted as the major surgical option for treating painful asymmetric ankle arthritis. The effectivenss of additional fibular valgization osteotomy during SMO procedure is still controversial. This study aimed to evaluate radiological and clinical outcomes of medial compartment ankle osteoarthritis (OA) after SMO with fibular valgization osteotomy. Also, the study is aimed to describe the radiographic support for the SMO with additional fibular osteotomy in relieving the medial ankle pain. M

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Drabovska, I. A., та G. S. Maslova. "THE ROLE OF Β2-MICROGLOBULIN IN ASSESSING THE PROGRESSION OF B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA". Актуальні проблеми сучасної медицини: Вісник Української медичної стоматологічної академії 24, № 4 (2024): 35–39. https://doi.org/10.31718/2077-1096.24.4.35.

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Introduction. The primary assessment of β2-microglobulin holds significant value in monitoring the dynamics of oncohematological processes, which can serve as a crucial marker for evaluating the baseline condition of patients with B-cell chronic lymphocytic leukemia. Aim: to analyze the levels of β2-microglobulin in patients experiencing progression of B-cell chronic lymphocytic leukemia. Materials and methods. Twenty six patients with progressive B-cell chronic lymphocytic leukemia (CLL) were examined, comprising 12 males (46%) and 14 females (54%). These patients were designated as Group I.

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Miletic, Marija, Razia Aslam, Catey Bunce, et al. "Therapeutic approaches and outcomes in patients aged 50+ with germ cell tumours." Journal of Clinical Oncology 43, no. 5_suppl (2025): 636. https://doi.org/10.1200/jco.2025.43.5_suppl.636.

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636 Background: Testicular germ cell tumours (GCT) are the most common malignancy in young men, mainly in their 30s. While multimodal treatment leads to excellent survival in younger patients (pts), its incidence is rising in men over 50, who often have comorbidities and higher risks of chemotherapy (ChT) toxicity. Limited data on outcomes in this group highlights the need for more research. Methods: We conducted a retrospective single centre study, analysing pts diagnosed with GCT aged 50 years or older between 2014 -2023. Results: 142 pts were analysed, median age of 57 years (range 50–83).

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Evens, Andrew M., Chadi Nabhan, Irene Helenowski, et al. "Multicenter Analysis of 150 Very Elderly Non-Hodgkin's Lymphoma (NHL) Patients: Impact of Comorbidities and Response to Initial Therapy on Survival." Blood 116, no. 21 (2010): 3124. http://dx.doi.org/10.1182/blood.v116.21.3124.3124.

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Abstract Abstract 3124 Background: The incidence of NHL increases exponentially with rising age. The most rapidly growing segment of the population is persons > age 65 years, especially > age 80. As a percentage of US population, the age group >80 years has increased by >250% from 1960 to 2000. Furthermore, persons >80 years will more than double within 20 years. However, little data is available regarding the characteristics or outcomes of very elderly NHL patients (pts). Methods: We completed a multicenter retrospective analysis of very elderly NHL pts (=/> 80) diagnosed (d

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Paviglianiti, Annalisa, Marta Bellver Sanchis, Marta Peña, et al. "Pre-Transplant Diabetes Is Associated with Increased Risk of Relapse after HCT: A Single Center Experience." Blood 144, Supplement 1 (2024): 7412. https://doi.org/10.1182/blood-2024-198124.

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Background: Evaluating nutritional status at allogeneic hematopoietic cell transplantation (HCT) is of outmost importance. Moreover, obesity and diabetes mellitus (DM) can modulate immune response, which may impact HCT outcomes. Methods: We retrospectively analyzed 158 patients who underwent HCT in a single center between January 2020 and June 2023. Nutritional status was assessed by Nutritional Risk Index (NRI) and Patient-Generated Subjective Global Assessment (PG-SGA). BMI (usual, pre-HCT and at discharge), previous diagnosis of DM and biochemical parameters were additionally collected. Res

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Ribera, Josep-Maria, Olga Garcia, Pascual Fernandez, et al. "Different Prognosis According to Subtype-Oriented Protocols in Elderly Patients with Acute Lymphoblastic Leukemia (ALL). Comparison of Three Prospective Parallel Trials from the Pethema Group." Blood 122, no. 21 (2013): 3869. http://dx.doi.org/10.1182/blood.v122.21.3869.3869.

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Abstract Background and objective ALL in elderly patients is associated with poor prognosis and many patients are not included in therapeutic trials. Consequently, the results of subtype-oriented protocols in elderly ALL are poorly known. We present the results of three prospective parallel subtype-oriented protocols from the Spanish PETHEMA group in ALL patients older than 55 years. Patients and Methods In 2008 three prospective phase II trials for ALL patients older than 55 yr with the Charlson Comorbidity Index ≤3 were activated: ALLOld07 (Ph-negative patients, NCT01366898, n=54), ALLOPh07

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Wattimena, Ferry, and Khaeroni Khaeroni. "Tingkat Motivasi Latihan Atlet Panahan Klub Al-Azhar 8 Kemang Pratama Bekasi." Jurnal Ilmiah Sport Coaching and Education 5, no. 2 (2021): 91–97. http://dx.doi.org/10.21009/jsce.05211.

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ABSTRAK Penelitian ini dilakukan bertujuan untuk mengetahui tingkat motivasi atlet yang mengikuti latihan panahan. Penelitian ini menggunakan pendekatan kuantitatif metode survey. Penelitian ini menggunakan pengambilan sampel yaitu total sampling dengan 45 atlet panahan di klub panahan Al-Azhar 8 Kemang Pratama Bekasi. Teknik pengumpulan data menggunakan kuesioner dengan 45 butir pernyataan, setiap pernyataan memiliki skala jawab “Sangat Tidak Setuju”, “Tidak Setuju”, “Ragu-Ragu”, “Setuju”, dan “Sangat Setuju”. Teknik analisis data pada penelitian ini adalah deskriptif kuantitatif. Hasil

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Annisa, Aulia Hutasuhut Muhammad Basri Zunidar. "The Use of The Make A Match Method In Improving Learning Outcomes in Mathematics Learning at State Primary School 136541 Tanjungbalai City." International Journal of Education, Information Technology and Others 7, no. 1 (2024): 199–208. https://doi.org/10.5281/zenodo.10547506.

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The problems found in this research were: low student mathematics learning outcomes, feeling bored while studying, lack of interest and attention of students towards the teacher during learning. This research aims to determine the learning outcomes of students at SD Negeri 136541 Tanjungbalai City for the 2023/2024 academic year learning mathematics on fractions, decimal and whole numbers. In cycle I, meeting I, there were no students who got a very high category score (0%), 2 students (8%) got a high category score, 11 students (40%) got a low category score, and 13 students (52%) got a very

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Simmons, Gary, Roy Sabo, Maja Radic, et al. "Safety and Tolerability of Intra-Venous Ascorbic Acid in Allogeneic Hematopoietic Cell Transplant Recipients: A Matched Historical Control Study." Blood 136, Supplement 1 (2020): 29–30. http://dx.doi.org/10.1182/blood-2020-138543.

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Intravenous (IV) ascorbic acid (AA) improves organ function and reduces inflammation in sepsis, an inflammatory state similar to the post-hematopoietic cell transplant (HCT) milieu. This salutary effect is mediated by antioxidant activity as well transcriptional modulation by AA. HCT recipients are deficient in AA, therefore we evaluated the safety and efficacy of patients receiving parenteral AA after myeloablative conditioning for allogeneic HCT compared to similarly treated historical controls who did not receive AA. Methods: Patients with hematologic malignancies, AML (48% of patients), AL

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Hoelzer, Dieter, Nicola Goekbuget, Joachim Beck, et al. "Subtype Adjusted Therapy Improves Outcome of Elderly Patients with Acute Lymphoblastic Leukemia (ALL)." Blood 104, no. 11 (2004): 2732. http://dx.doi.org/10.1182/blood.v104.11.2732.2732.

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Abstract Despite the major peak of ALL in childhood the incidence also increases in the elderly beyond 50 yrs. Outcome of these elderly ALL pts is very poor. In a survey including 12 studies with 370 pts (50–88 yrs) the mean CR rate was 50% and the rate of continuous CR (CCR) 13%. Also in a first prospective pilot study of the German Multicenter Study Group for Adult ALL (GMALL) for elderly ALL pts &gt; 65 yrs with a moderate intensive chemotherapy regimen (Blood, 96(11): 3104a, 2000) the results in 94 pts were poor with a CR rate of 48% and a survival (OS) &lt;10%. Therefore in 2003 t

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Вавин, В. В., И. И. Нажмудинов, Б. Х. Давудова, К. М. Магомедова, and Х. Ш. Давудов. "Surgical Treatment of Chronic Cicatricial Stenosis of the Vestibular Larynx." Оториноларингология. Восточная Европа 14, no. 2 (2024): 192–202. http://dx.doi.org/10.34883/pi.2024.14.2.031.

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Введение. Проблема хронического рубцового стеноза гортани и трахеи актуальна в связи с сохраняющимся большим числом пациентов с данной патологией. Многочисленные работы, посвященные стенозу гортани и трахеи, в большинстве случаев посвящены поражению подскладочного и голосового отделов гортани. При этом стеноз вестибулярного отдела считается достаточно редким полиэтиологичным заболеванием, требующим детального изучения. Цель. Провести анализ клинических случаев и результатов лечения пациентов с хроническим рубцовым стенозом вестибулярного отдела гортани для выявления закономерностей течения заб

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