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Journal articles on the topic 'Tocolytic effects'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Lee, Howard Hao, Chang-Ching Yeh, Szu-Ting Yang, Chia-Hao Liu, Yi-Jen Chen, and Peng-Hui Wang. "Tocolytic Treatment for the Prevention of Preterm Birth from a Taiwanese Perspective: A Survey of Taiwanese Obstetric Specialists." International Journal of Environmental Research and Public Health 19, no. 7 (2022): 4222. http://dx.doi.org/10.3390/ijerph19074222.

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Preterm birth represents a great burden to the healthcare system, resulting in the consideration for the use of tocolytic therapy to provide a “better time” for delivery in order to buy time to accelerate fetal lung maturity, thereby minimizing prematurity-related morbidity and mortality. However, the benefits and potential side effects and risks of tocolytic treatment for preterm birth should be carefully balanced. Although many countries and societies provide guidelines or consensuses for the management for preterm birth, there is no standardized national guideline or consensus in Taiwan. As

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Nasreen, Sk Zinnat Ara, Safinaz Shahreen, and Shahnaz Rahman. "Recent Update on Tocolytics for the Management of Preterm Labour." Bangladesh Journal of Obstetrics & Gynaecology 27, no. 1 (2016): 21–26. http://dx.doi.org/10.3329/bjog.v27i1.29910.

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Tocolysis is the relaxation of the pregnant uterus to postpone delivery. Tocolytics are a wide variety of agents used to suppress uterine contraction given when delivery would result in preterm birth. Preterm birth the most important single determinant of adverse outcome in terms of both survival and quality of life of baby. Although preterm birth is defined as being before 37 completed weeks most mortality and morbidity is experienced by babies born before 34 weeks. Prevention and treatment of preterm birth is important though it is not possible when labour is too advanced, cervix is dilated

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Coler, Brahm Seymour, Oksana Shynlova, Adam Boros-Rausch, et al. "Landscape of Preterm Birth Therapeutics and a Path Forward." Journal of Clinical Medicine 10, no. 13 (2021): 2912. http://dx.doi.org/10.3390/jcm10132912.

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Preterm birth (PTB) remains the leading cause of infant morbidity and mortality. Despite 50 years of research, therapeutic options are limited and many lack clear efficacy. Tocolytic agents are drugs that briefly delay PTB, typically to allow antenatal corticosteroid administration for accelerating fetal lung maturity or to transfer patients to high-level care facilities. Globally, there is an unmet need for better tocolytic agents, particularly in low- and middle-income countries. Although most tocolytics, such as betamimetics and indomethacin, suppress downstream mediators of the parturition

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O'Donnell, James, and Leslie Iffy. "Cardiopulmonary Adverse Effects of Oral and Subcutaneous Terbutaline for Tocolysis." Journal of Pharmacy Practice 9, no. 3 (1996): 181–87. http://dx.doi.org/10.1177/089719009600900305.

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Are there differences between the expected or reported adverse reactions associated with terbutaline when administered orally as opposed to the parenteral routes (such as subcutaneously or intravenously)? This is a report on a pulmonary edema and subsequent death of a laboring woman who was treated with a combination of tocolytic agents in an attempt to prolong the gestation. The agents included magnesium sulfate, and subcutaneous and oral terbutaline. The intention is to alert the reader to the cardiovascular risks associated with combining tocolytic agents, and to dispel a pervasive myth tha

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Jeswani, Rohit, Yamini Patil, Sangeeta Lalwani, and Monika Dudve. "A Comparative Study Between Intravenous Magnesium Sulphate and Intravenous Isoxsuprine for Arrest of Preterm Labour." National Journal of Medical Research 14, no. 01 (2024): 11–16. http://dx.doi.org/10.55489/njmr.14012024988.

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Introduction: Wide use of medical management of preterm labour has been obstructed due to low success rate of arrest of labour. This is aggravated by higher incidence of serious side effect of the available tocolytic agents, especially beta-mimetic tocolytics. With this background, the present study was carried out to compare the efficacy and maternal side effect of magnesium sulphate and Isoxsuprine in the arrest of preterm labour Methodology: This was a comparative prospective interventional study conducted among pregnant women coming to department of obstetrics and gynaecology with 28

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Kirchhoff, Ebba, Verena Schneider, Gerhard Pichler, et al. "Hexoprenaline Compared with Atosiban as Tocolytic Treatment for Preterm Labor." Geburtshilfe und Frauenheilkunde 82, no. 08 (2022): 852–58. http://dx.doi.org/10.1055/a-1823-0176.

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Abstract Introduction Preterm birth is defined as a live birth before 37 weeks of gestation and is associated with increased neonatal morbidity and mortality. The aim of this study is to compare the efficacy of hexoprenaline and atosiban for short- and long-term tocolysis and their effects on neonatal and maternal outcomes. Methods This retrospective cohort study included women with threatened preterm labor between 24 + 0 and 34 + 0 weeks of gestation without premature rupture of membranes. The tocolytic efficacy of hexoprenaline and atosiban was compared in women receiving one of the two medi

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Baev, O. R., O. N. Vasilchenko, and A. O. Karapetyan. "Modern tocolysis and adverse effects of tocolytics." Gynecology 20, no. 2 (2018): 46–50. http://dx.doi.org/10.26442/2079-5696_2018.2.46-50.

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Relevance. Toсolytic therapy is the only method that is used in the treatment of pregnant women with preterm labor. However, the effectiveness and safety of this therapy is still a matter of debate. One of the least studied issues of this problem is the safety of therapy, which is primarily manifested by the frequency of side effects. The aim is to carry out a comparative study of the safety of the most common tocolytic agents - atosiban, nifedipine and hexoprenaline sulfate. Material and methods. The study included 173 pregnant women with threatening premature births in a period of 28 to 34 w

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Gureeva, L. V., O. M. Chistyakova, E. K. Paramonova, and O. V. Radkov. "Influence of Tocolytic Therapy with Hexoprenaline on Heart Rate Variability, Lipid Spectrum and Glycemic Level in Obese Pregnant Women." Acta Biomedica Scientifica 6, no. 1 (2021): 7–12. http://dx.doi.org/10.29413/abs.2021-6.1.1.

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Background. Obesity is associated with the risk of spontaneous preterm birth. Hexoprenaline is the effective and most widely used tocolytic agent, possessing however a significant number of side effects. The effect of hexoprenaline tocolysis on heart rate variability, lipid spectrum and glycaemia level in obese pregnant women remain unexplored.Aim of the research. To study the effect of tocolytic therapy with hexoprenaline on heart rate variability, lipid spectrum and glycemic level in obese pregnant women.Materials and methods. The study included two groups of pregnant women with threatened p

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Yamaji, Noyuri, Hitomi Suzuki, Kana Saito, et al. "Tocolytic Therapy Inhibiting Preterm Birth in High-Risk Populations: A Systematic Review and Meta-Analysis." Children 10, no. 3 (2023): 443. http://dx.doi.org/10.3390/children10030443.

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This systematic review aimed to identify the benefits and possible harms of tocolytic therapy for preterm labour management in the context of pregnant women with extremely preterm birth, multiple gestations, or growth-restricted foetuses. A comprehensive search using MEDLINE, Embase, the Cochrane Central Register of Controlled Trials, CINAHL, and the WHO Global Index Medicus databases was conducted from 10 to 15 July 2021. We included randomized controlled trials and non-randomized studies that assessed the effects of tocolysis compared with placebo or no treatment. We found 744 reports and, f

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Patil, Yamini, Padmaja A. Havle, Shivaji V. Raje, and Gauri Shinde. "Preterm Labor with Side Effects: Compare the Effectiveness of Magnesium Sulfate (MgSO4) with Isoxsuprine." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 03 (2023): 786–90. http://dx.doi.org/10.25258/ijpqa.14.3.55.

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Background: In India, 25% of pregnancies develop preterm labor (PTL), resulting in 10 to 69% cases of preterm birth. Medical intervention to stop labor, reduce infection rate, and avoid infant respiratory distress has been the subject of studies for a long time. PTL patients usually get tocolytics, corticosteroids, antibiotics, and other clinically symptomatic and supportive therapy to accomplish this goal. Studies further showed that these tocolytic drugs lower intracellular calcium bioavailability via biochemical pathways, hindering the interaction of actin-myosin. Due to the poor success ra

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Hubinont, C., and F. Debieve. "Prevention of Preterm Labour: 2011 Update on Tocolysis." Journal of Pregnancy 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/941057.

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The aim of this paper is to review available data about drugs for preventing preterm labour. Tocolytic therapy includesβadrenergic receptor agonists, NO donors, magnesium sulphate, prostaglandin-synthase inhibitors, oxytocin receptor antagonists, calcium-channel blockers, progesterone, 17-α-hydroxyprogesterone caproate, and antibiotics. Their specific effects on myometrial contractility, their safety, their efficiency, and side effects profile for the mother and the fetus are presented. The main question of why and for what reasons tocolysis should be administrated is discussed.

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Gowda, Veena Bikkolli Teekappa, and Madhubala Kalidoss. "Efficacy of oral nifedipine as a tocolytic agent." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 9 (2021): 3450. http://dx.doi.org/10.18203/2320-1770.ijrcog20213468.

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Background: Preterm birth is defined as birth at less than 37 weeks period of gestation, is the most important single determinant of adverse infant outcome in terms of both survival and quality of life. The need for tocolysis in terms of safety and efficacy is necessary to decrease perinatal mortality and morbidity in preterm labour. This study was aimed to evaluate the effectiveness of nifedipine as a tocolytic for inhibiting uterine contraction in threatened preterm labour.Methods: It was a prospective, nonblinded, single centred, randomized control trial. This study included 100 cases of pr

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Ni Putu Ika Regiana Maharani, I Gede Agus Rio Saputra, Anak Agung Ngurah Gede Anggra Pramana, and I Putu Gede Budiana. "Impact of Tocolytic Therapy on Cardiovascular Outcomes in Preterm Labor: A Systematic Review and Meta-Analysis." Bioscientia Medicina : Journal of Biomedicine and Translational Research 9, no. 5 (2025): 7413–25. https://doi.org/10.37275/bsm.v9i5.1283.

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Background: Preterm labor is a significant cause of neonatal morbidity and mortality, and tocolytic therapy is often used to delay delivery and improve neonatal outcomes. However, tocolytic drugs can have adverse cardiovascular effects, including an increased risk of atrial fibrillation (AF). This meta-analysis aims to evaluate the impact of tocolytic therapy on cardiovascular outcomes in preterm labor, focusing on the risk of AF. Methods: A systematic literature review was conducted following PRISMA guidelines. Relevant studies published between 2013 and 2024 were identified through PubMed, S

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Liu, Jui-Ming, Chien-Yu Liu, Ren-Jun Hsu, and Fung-Wei Chang. "Preterm Labor Using Tocolysis as a Possible Risk Factor for Postpartum Depression: A 14-Year Population-Based Study in Taiwan." International Journal of Environmental Research and Public Health 18, no. 13 (2021): 7211. http://dx.doi.org/10.3390/ijerph18137211.

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Postpartum depression (PPD) is associated with negative physical and mental health outcomes for the mother and infant. Women often experience elevated symptoms of PPD, and the incidence of PPD has increased in recent years. There were lack of studies to investigate the effects of medications during pregnancy. Herein, we focused on the most common obstetric medical therapies used in labor and determined whether the medical therapies cause mental stress in pregnant women. This 14-year retrospective population-based nationwide study was based on the National Health Insurance Research Database. Un

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Caritis, Steve. "Adverse effects of tocolytic therapy." BJOG: An International Journal of Obstetrics & Gynaecology 112 (February 16, 2005): 74–78. http://dx.doi.org/10.1111/j.1471-0528.2005.00590.x.

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Spirlet, Marina de, Jean-Marc Treluyer, Sylvie Chevret, et al. "Tocolytic effects of intravenous nitroglycerin." Fundamental and Clinical Pharmacology 18, no. 2 (2004): 207–17. http://dx.doi.org/10.1111/j.1472-8206.2003.00231.x.

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Parsons, M. T., C. A. Owens, and W. N. Spellacy. "Thermic Effects of Tocolytic Agents." Obstetric Anesthesia Digest 7, no. 3 (1987): 119. http://dx.doi.org/10.1097/00132582-198710000-00033.

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H. Sharif Al-Shibany, Yasamin, and Saba M. Swadi Al- Thuwainy. "Effectiveness and safety of the oxytocin antagonist( atosiban) versus beta-adrenergic agonists (salbutamol) in the treatment of preterm labor." AL-QADISIYAH MEDICAL JOURNAL 11, no. 20 (2017): 176–83. http://dx.doi.org/10.28922/qmj.2015.11.20.176-183.

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Background and Objectives: preterm labor complicates 5-10% of pregnancies and is a leading cause of neonatal morbidity and mortality worldwide and 70-80% of perinatal deaths occur in preterm infants. The aim of this study is to compare the effectiveness, safety and adverse effects of the oxytocin antagonist medication(atosiban) with those of beta-adrenergic agonist (salbutamol) in the treatment of patients with preterm labor.Patients and Methods: one hundred pregnant women with preterm labor were enrolled in this study from the period of( January 2014 â€“ January 2015) at Al-Diwaniya Maternity

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Kalburgi, Ashish P., and Nitin Kshirsagar. "WHICH ONE IS BETTER FOR TOCOLYSIS IN PRE-TERM LABOR?: ORAL NIFEDIPINE VS TRANSDER-MAL NITROGLYCERIN PATCH." National Journal of Medical Research 13, no. 02 (2023): 50–58. http://dx.doi.org/10.55489/njmr.13022023961.

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Introduction: Preterm labour follows a spontaneous commencement of labour in two-thirds of preterm birth instances. Obstetricians must consider both treatment options for the management of preterm. The study was conducted to compare the tocolytic effects of oral nifedipine tablets and transdermal nitroglycerine patches in preterm labor. Methodology: Cases with Singleton pregnancy, Pregnancy between 28 weeks to 36 completed weeks, and without contraindication for tocolysis were included in the study. Randomly assigned Nifedipine group received oral nifedipine (Tab Depin 10mg) and NTG grou

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El Megeed, Salwa A., Abeer S. Esawi, and Hanan F. Azzam. "Outcomes of nursing monitoring for pregnant women under tocolytic therapies: a comparative study." Egyptian Nursing Journal 20, no. 2 (2023): 319–26. http://dx.doi.org/10.4103/enj.enj_30_23.

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Background Preterm birth (PTB) is the most common cause of neonatal morbidity and mortality worldwide. Tocolytic drugs had not been shown to improve fetal outcome, but were used to postpone delivery for 48 h to allow for maximal effect of parenteral steroids administered to the mother. The aim of the current study was to evaluate the outcomes of nursing monitoring for the pregnant mother under tocolytic therapy. Design An observational, comparative design was used to achieve the aim of the study. Setting The study was conducted at El Manial University Hosbital and El Galaa Maternity Teaching H

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Tambat, Anand, Prashant Athawale, and Chaitanya Deore. "Gauging the safety and efficacy of nitroglycerine used transdermally as a tocolytic agent in females with preterm labor." Muller Journal of Medical Sciences and Research 16, no. 1 (2025): 7–11. https://doi.org/10.4103/mjmsr.mjmsr_4_24.

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ABSTRACT Background: Preterm labor is the primary challenge in prenatal health care, leading to a high rate of mortality. As a result, in pregnant women with preterm labor, we use nitroglycerine transdermally as a tocolytic agent. The main objective of this study was to determine the best effective tocolytic agents for preterm laboring ladies to optimize their benefits. Thus, the purpose of the present study was to analyze the impact of using nitroglycerin dermal patch as a tocolytic for the management of preterm labor and to assess its side effects. Methodology: A prospective study was conduc

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Pryde, Peter G., Susan Janeczek, and Robert Mittendorf. "Risk–benefit effects of tocolytic therapy." Expert Opinion on Drug Safety 3, no. 6 (2004): 639–54. http://dx.doi.org/10.1517/14740338.3.6.639.

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Segal, S., A. Csavoy, and S. Datta. "A915 Tocolytic effects of maternal catecholamines." Anesthesiology 87, Supplement (1997): 915A. http://dx.doi.org/10.1097/00000542-199709001-00915.

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Mathuriya, Gayatri, and Ritu Tarware. "A comparative study of magnesium sulphate and isoxsuprine as a tocolytic in preterm labour." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 3 (2021): 950. http://dx.doi.org/10.18203/2320-1770.ijrcog20210714.

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Background: Preterm birth is a significant health problem across the world because of associated neonatal mortality and short-and long-term morbidity in later life. The incidence in India is higher than developed countries.Methods: The present study conducted in the Department of Obstetrics and Gynaecology, MGM Medical College and M. Y. Hospital. Indore, (Madhya Pradesh). The patients selected from labour rooms.100 antenatal women of gestational age between 28 weeks to 37 weeks presenting with preterm labor, 50 in each group. Group A consisted women receiving magnesium sulphate, group B had wo

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Pryde, Peter G., Richard E. Besinger, John G. Gianopoulos, and Robert Mittendorf. "Adverse and beneficial effects of tocolytic therapy." Seminars in Perinatology 25, no. 5 (2001): 316–40. http://dx.doi.org/10.1053/sper.2001.27547.

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Elliott, John P., and John C. Morrison. "The Evidence Regarding Maintenance Tocolysis." Obstetrics and Gynecology International 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/708023.

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Preterm delivery is a public health issue of major proportion. More than 12% of deliveries in the United States that occur at less than 37 weeks gestation preterm labor (PTL) represents the largest single reason for preterm birth (PTB). Attempts to prevent PTB have been unsuccessful. This paper of maintenance tocolytic therapy will examine the efficacy and safety of the drugs, both oral and subcutaneous, which have been utilized for prolongation of pregnancy following successful arrest of a documented episode of acute preterm labor. The evidence for oral tocolytics as maintenance therapy as we

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D., Rita, and V. Haripriya. "Comparative study of efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1-year study at navodaya medical college hospital and research centre Raichur." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 10, no. 7 (2021): 2806. http://dx.doi.org/10.18203/2320-1770.ijrcog20212672.

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Background: Tocolytic agents are used to reduce preterm deliveries. Very few studies documenting the comparison of tocolytic agents viz. nifedipine, nitroglycerin dermal patches and isoxsuprine. Other drugs are not used due to their adverse effects. Objective was to study and compare the safety efficacy of nifedipine, nitroglycerin dermal patches and isoxsuprine as tocolytic agents in suppression of preterm labour 1 year study.Methods: This was a prospective case control study was conducted for a period of 1 year. Total 90 cases selected to study were randomly distribute in to three treatment

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McCombs, Janet. "Update on Tocolytic Therapy." Annals of Pharmacotherapy 29, no. 5 (1995): 515–22. http://dx.doi.org/10.1177/106002809502900511.

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Objective: To review medications currently being used or investigated for the treatment of preterm labor. Adverse effects, pharmacoeconomic issues, and therapeutic controversies are included. Data Sources: A MEDLINE search, limited to English-language articles and publication years of 1989–1994, was used to identify pertinent literature. Additional references were identified from articles retrieved in the search. Study Selection: Studies were chosen on drugs that are available or whose approval is anticipated in the US: ritodrine, terbutaline, hexoprenaline, and magnesium sulfate. Several stud

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BN, Seema, and Tejaswi V. Pujar. "Comparison of safety, efficacy and perinatal outcome of isoxsuprine and nifedipine in women with preterm labour." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 2 (2017): 400. http://dx.doi.org/10.18203/2320-1770.ijrcog20164845.

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Background: Over the last 50 years, extensive research has been conducted with the objective of preventing, predicting and optimizing the outcome of patients with preterm labour. Currently, the therapeutic foundation for treating preterm labour involves the use of tocolysis. An attempt is made to study the tocolytic effect of Isoxsuprine and nifedipine in suppression of preterm labour.Methods: This is a prospective study, carried out in the department of Obstetrics and Gynaecology of S S institute of medical sciences and research centre, Davangere, over a period of 15 months- from October 2014

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Singh, Sapna, Preeti Tyagi, Deepak Anand, Nitika Gupta, and Rashmi Gupta. "A comparative study of efficacy and side effects of nifedipine with nifedipine along with dydrogesterone in management of preterm labor." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 12, no. 6 (2023): 1670–74. http://dx.doi.org/10.18203/2320-1770.ijrcog20231534.

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Background: Preterm labor remains one of the major cause of neonatal morbidity and mortality. Different tocolytics have been studied for prolongation of pregnancy, role of progesterone in increasing latency period remains controversial. Aim of the study was to compare efficacy of nifedipine with nifedipine along with dydrogesterone as a tocolytic agent in case of preterm labor and find its impact on maternal and neonatal outcome. Methods: This study was conducted in 100 women who presented with symptoms of preterm labor, patients were then randomized to nifedipine plus dydrogesterone therapy o

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Ziganshin, Aydar M., and Elena V. Akbulatova. "Tocolytics in obstetric practice." Journal of obstetrics and women's diseases 72, no. 2 (2023): 85–93. http://dx.doi.org/10.17816/jowd115201.

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Preterm birth remains a leading cause of perinatal mortality and morbidity in preterm infants and leads to significant annual health care costs. A special role in preventing premature birth belongs to tocolytic therapy, which allows for prolonging pregnancy and avoiding various complications. However, questions arise about the efficacy and safety of this therapy, which can be manifested by various isolated and combined side effects. The aim of the study was to assess the effectiveness and complications of tocolytic therapy. We analyzed the literature on eLibrary, Medline, Scopus, Cochrane Libr

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Karmo, Hadeer N., Kenny K. Robbins, Robert A. Parker, Richard L. Rosemond, and Robert B. Cotton. "Effects of Tocolytic Indomethacin on Neonatal Renal Function." Journal of Maternal-Fetal and Neonatal Medicine 4, no. 2 (1995): 65–70. http://dx.doi.org/10.3109/14767059509017300.

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Lee, Seung Mi, Yoomi Park, Young Ju Kim, et al. "Identifying genetic variants associated with ritodrine-induced pulmonary edema." PLOS ONE 15, no. 11 (2020): e0241215. http://dx.doi.org/10.1371/journal.pone.0241215.

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Introduction Ritodrine is one of the most commonly used tocolytics in preterm labor, acting as a ß2-adrenergic agonist that reduces intracellular calcium levels and prevents myometrial activation. Ritodrine infusion can result in serious maternal complications, and pulmonary edema is a particular concern among these. The cause of pulmonary edema following ritodrine treatment is multifactorial; however, the contributing genetic factors remain poorly understood. This study investigates the genetic variants associated with ritodrine-induced pulmonary edema. Methods In this case-control study, 16

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Yilmaz, Osman, and Ayhan Şule Göncü. "Effects of nifedipine on fetal cardiac function in preterm labor." Journal of Perinatal Medicine 48, no. 7 (2020): 723–27. http://dx.doi.org/10.1515/jpm-2020-0160.

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AbstractObjectivesTo evaluate the effects of nifedipine treatment on fetal hemodynamics and cardiac function during preterm labor. This prospective study assessed several quantitative parameters of fetal cardiac circulation and function, and found no significant changes at 48 h after nifedipine treatment. These findings suggest that tocolytic nifedipine may be safe for fetuses. It supports clinicians to use nifedipine treatment for tocolysis without any cardiac effect on the fetus.MethodsA prospective cohort study was conducted at a tertiary hospital between January 2016 and October 2017. A to

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Proklova, G. F., R. A. Chilova, E. A. Sokova та ін. "Effect of ADRB2 gene polymorphism on the efficacy and safety of tocolytic therapy with β2-adrenergic agonists in preterm birth". Russian Journal of Woman and Child Health 3, № 3 (2020): 194–97. http://dx.doi.org/10.32364/2618-8430-2020-3-3-194-197.

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This paper reviews the effects of ADRB2 gene polymorphism on the efficacy of tocolytic therapy in preterm birth. Statistically, prematurity accounts for 70% to 75% of neonatal and infant mortality while stillbirths are 13 times more common in preterm birth compared to full-term birth. Despite modern diagnostic and treatment options to manage threatened preterm labor, its rate does not reduce. Meanwhile, pregnancy prolongation even by 48 hours is often enough to prevent newborn respiratory distress syndrome thereby improving perinatal outcomes, saving many lives of preterm babies, and preventin

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Golichowski, Alan M., David R. Hathaway, Naomi Fineberg, and Dan Peleg. "Tocolytic and hemodynamic effects of nifedipine in the ewe." American Journal of Obstetrics and Gynecology 151, no. 8 (1985): 1134–40. http://dx.doi.org/10.1016/0002-9378(85)90397-7.

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Dewan, Bhupesh, Sanjaykumar Navale, and Rishima Ganiga. "Atosiban: a comprehensive approach to preterm labour management." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 13, no. 11 (2024): 3420–31. http://dx.doi.org/10.18203/2320-1770.ijrcog20243223.

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Preterm birth (PTB) continues to be a leading cause of neonatal mortality and long-term complications globally, reinforcing the need for effective and safe tocolytic treatments. Atosiban, an oxytocin receptor antagonist, has emerged as a pivotal intervention for managing spontaneous preterm labour (sPTL) due to its targeted mechanism and favourable safety profile. This is especially critical in regions like India, where there is a significant therapeutic gap in the availability of effective, safe, and cost-efficient tocolytic agents. Dosing regimens for Atosiban include a full course (48 hours

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Ogbeide, Uyi, Eunice Oriotor, and Henry Okeri. "Molecular docking assessment of the tocolytic potential of phytoconstituents of five medicinal plants used against preterm labour." Journal of Science and Practice of Pharmacy 10, no. 1 (2023): 522–32. http://dx.doi.org/10.47227/jsppharm.v10i1.5.

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Introduction: Preterm labour is currently being treated with a number of medications with untoward side effects, but many medicinal plants have also been found useful. This study aims to assess the tocolytic potentials of the phytoconstituents of Barteria fistulosa, Ficus capensis, Ficus exasperate, Newbouldia laevis and Zingiber officinale. Methods: Phytoconstituents present in these plants were obtained from literature sources, their 3D SDF structures were obtained from PubChem; the protein Beta-2 adrenergic receptor (7DHI) was processed using Chimera and molecular docking was done using PyR

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Sоkоvа, E. A., R. A. Chilova, O. A. Demidova, and K. O. Akopov. "Clinical Pharmacology Aspects of Some Tocolytic Drugs Used in Pregnant Women at Risk of Preterm Birth." Bulletin of the Scientific Centre for Expert Evaluation of Medicinal Products 9, no. 3 (2019): 162–66. http://dx.doi.org/10.30895/1991-2919-2019-9-3-162-166.

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Spontaneous preterm birth is one of the most pressing issues in obstetrics, as it remains one of the leading causes of newborn morbidity and mortality. Pending issues of aetiology, pathogenesis, and absence of medicinal products indicated for the treatment of spontaneous preterm labour pose a challenge for rational pharmacotherapy. The paper presents the results of a scientific literature review on the problem of rational pharmacotherapy of spontaneous preterm labour using tocolytic drugs — calcium channel blockers, cyclooxygenase inhibitors. The paper summarises specific pharmacokinetic param

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Vesalainen, Risto K., Eeva M. K. Ekholm, Thomas T. Jartti, Kari U. O. Tahvanainen, Timo J. Kaila, and Risto U. Erkkola. "Effects of tocolytic treatment with ritodrine on cardiovascular autonomic regulation." BJOG: An International Journal of Obstetrics and Gynaecology 106, no. 3 (1999): 238–43. http://dx.doi.org/10.1111/j.1471-0528.1999.tb08237.x.

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Ofulue, Ofioritse Ogheneyoma, Ejiro Peggy Ohwin, Adaeze Phina Uchendu, Emuesiri Kohworho Umukoro, and Emuesiri Goodies Moke. "Biologic Proteins with Tocolytic Effects and Their Mechanisms: A Review." International Journal of Pharmaceutical And Phytopharmacological Research 12, no. 6 (2022): 1–7. http://dx.doi.org/10.51847/niomujtzvs.

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Rousseau, Éric, Karine Labelle, and Laurence Massenavette. "Involvement of Alternative Calcium Conductance on Human Myometrial Contractile and Pharmacological Properties." Current Opinion in Gynecology and Obstetrics 1, no. 1 (2018): 100–110. http://dx.doi.org/10.18314/cogo.v1i1.1288.

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Objective: This study aimed to investigate the physiological role of alternative calcium conduct once contractions triggered by oxytocin and PGF? in human myometrium. This conductance, supported by TRPC and TRPV channels, may provide alternative pathways to control either free intracellular and/or submembrane Ca2+ - concentrations, which in turn will modulate membrane polarization and contractile responses. Study design: Uterine biopsies were obtained from consenting women undergoing elective caesarian delivery at term without labor (N = 29). Isometric tension measurements were performed on ut

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Padmini, Ghosh, Anand Niharika, Sinha Anupama, and Singh Anupma. "The Role of Magnesium Sulfate as a Tocolytic Agent in Preterm Labor and its Impact on Maternal Health: A Cohort Study." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 1313–17. https://doi.org/10.5281/zenodo.12754314.

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<strong>Background</strong><strong>:</strong> Preterm labor, classified as labor occurring before 37 completed weeks of gestation, poses significant risks to neonatal health, including intraventricular hemorrhage, respiratory distress syndrome, and long-term neurodevelopmental disabilities. Magnesium sulfate, traditionally used for eclampsia management, has gained attention as a tocolytic agent to delay preterm delivery and improve newborn outcomes. This study aimed to evaluate the effectiveness and safety of magnesium sulfate as a tocolytic agent in preterm labor and its impact on matern

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Eriksson, H., P. Björgell, M. Åkerlund, A. Hauksson, and P. Melin. "Effects of a Tocolytic Oxytocin Analogue on Lipid and Carbohydrate Metabolism." Gynecologic and Obstetric Investigation 29, no. 2 (1990): 97–100. http://dx.doi.org/10.1159/000293310.

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Zuckerman, H., and E. Shalev. "Fetal and neonatal effects of indomethacin used as a tocolytic agent." American Journal of Obstetrics and Gynecology 153, no. 6 (1985): 712–13. http://dx.doi.org/10.1016/s0002-9378(85)80270-2.

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Dudley, Denis K. L., and M. J. Hardie. "Fetal and neonatal effects of indomethacin used as a tocolytic agent." American Journal of Obstetrics and Gynecology 151, no. 2 (1985): 181–84. http://dx.doi.org/10.1016/0002-9378(85)90008-0.

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Veersema, Diederik, Pieter A. de Jong, and Jacobus A. M. van Wijck. "Fetal and neonatal effects of indomethacin used as a tocolytic agent." American Journal of Obstetrics and Gynecology 153, no. 8 (1985): 926–27. http://dx.doi.org/10.1016/0002-9378(85)90712-4.

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Wolff, F., V. Carstens, J. H. Fischer, D. Behrenbeck, and A. Bolte. "Cardiopulmonary effects of betamimetic tocolytic and glucocorticoid therapy in pregnant women." Archives of Gynecology 239, no. 1 (1986): 49–58. http://dx.doi.org/10.1007/bf02134288.

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Leush, S. S., D. О. Govsіeіev, and O. S. Zahorodnia. "Tocolytic therapy safeness in various gestational terms." UKRAINIAN JOURNAL HEALTH OF WOMAN, no. 4(173) (September 28, 2024): 26–32. http://dx.doi.org/10.15574/hw.2024.4(173).2632.

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Hexoprenaline and nifedipine, known for their side effects, are currently most often used for tocolysis. Duration of use and interactions with other drugs require further study. Aim was to compare the clinical and laboratory manifestations and consequences of tocolysis with hexporenaline and nifedipine in neonates and mothers. Materials and methods. The results of tocolysis with hexoprenaline and nifedipine for more or less than 48 hours before delivery time were compared in extremely premature terms of labor (EPP group - 22-27 weeks, 77 parturients) and in terms of moderate premature parturit

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WAHEED, AFIFA, and NABEELA SHAMI. "PRETERM LABOUR." Professional Medical Journal 18, no. 02 (2011): 174–80. http://dx.doi.org/10.29309/tpmj/2011.18.02.2048.

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Objective: To determine the effectiveness of transdermal patch of glyceryl trinitrate as tocolytic agent. Study design: Interventional- Quasi experimental study. Setting: Department of Obstetrics and Gynecology Unit- 1, Services hospital, Lahore. Duration with dates: One year (February 10, 2006 – February 10, 2007). Sample size: Fifty pregnant women with preterm labour were included in the study. Results: 54% of pregnant women were between G2 – G4. Majority (48%) of the women presented between 31 – 34 weeks of gestation. 46% of pregnant women had bishop score of 4 or more. 64% of patients foun

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