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Goschy, Harriet-Rosita. "Top-down shielding from distraction in visual attention." Diss., Ludwig-Maximilians-Universität München, 2014. http://nbn-resolving.de/urn:nbn:de:bvb:19-171000.
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The present work examines top-down shielding from distraction in visual attention; that is, under which circumstances can the intentions and goals of an observer counteract the bottom-up salience of irrelevant distractors. Several factors of influence will be considered: First, prior experience with distractors, i.e. did observers previously acquire an effective distractor shielding strategy; second, intra- vs. cross-dimensionality of distractors, i.e. are irrelevant distractors defined in the same feature dimension (e.g., shape, color) as the target or in a different feature dimension; third, time, i.e. how effective is distractor shielding early vs. later in processing; and finally, the incentive for effective distractor shielding.
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Rossi, Stefano [Verfasser]. "Nanocrystalline diamond growth for top heat-spreading applications on GaN-based devices / Stefano Rossi." Ulm : Universität Ulm. Fakultät für Ingenieurwissenschaften und Informatik, 2015. http://d-nb.info/1077559380/34.
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Cela, David. "Correlation of bullet dispersion and transverse barrel tip displacement on a firing PHALANX gun system." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1994. http://handle.dtic.mil/100.2/ADA294604.
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Chavoor, Greg. "Light Extraction Enhancement of GaN Based LEDs Using Top Gratings, Patterned Sapphire Substrates, and Reflective Surfaces." DigitalCommons@CalPoly, 2012. https://digitalcommons.calpoly.edu/theses/737.
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In the last 15 years, an immense amount of research has gone into developing high efficiency Gallium Nitride based light emitting diodes (LED). These devices have become increasingly popular in LED displays and solid state lighting. Due to the large difference in refractive index between GaN and Air, a significant amount of light reflects at the boundary and does not escape the device. This drawback decreases external quantum efficiency (EQE) by minimizing light extraction. Scientists and engineers continue to develop creative solutions to enhance light extraction. Some solutions include surface roughening, patterned sapphire substrates, and reflective layers.
This study proposes to increase external quantum efficiency and optimize light extraction efficiency of several LED structures using finite difference time domain analysis (FDTD). The structures under investigation include GaN based LEDs with nanoscale top gratings, patterned sapphire substrates in combination with SiO2 nanorod arrays, and reflective surfaces below and above the sapphire substrate. First, we optimize GaN based nanoscale top gratings and increase light extraction by 17.8%. Next, we simulate ITO based top gratings and enhance light extraction by 40%. Third, we optimize patterned sapphire substrate period and width and the vertical position of a SiO2 nanorod array. We achieve as high as 51.8% improvement in light extraction. Finally, we increase light extraction by 160% with the use of a silver reflection layer.
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Navarrete, Rivas José Luis. "“TOM Gunn’s poetry: A question of male afecction”, “La poesía de TOM Gunn: Una pregunta en torno a la afectividad masculina” (versión en inglés)." Tesis, Universidad de Chile, 2002. http://repositorio.uchile.cl/handle/2250/110061.
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El objetivo del trabajo es presentar rasgos temáticos y estilísticos de la poesía de Thom Gunn. Este es un poeta británico y lo he elegido por su prolífica obra, en la cual se integran temáticas culturales y políticas como parte de su carrera como poeta. Desde sus comienzos como estudiante de Cambridge, "de algún modo, el carácter y la máscara de los poemas de Gunn es lo que Christopher Isherwood definió como "El Hombre Realmente Débil", que siempre toma una vía circular y más peligrosa porque no puede enfrentarse a decisiones tajantes que lo lanzarían a un viaje mucho más directo. Estas consideraciones hacen que Gunn sea un poeta sumamente interesante desde una perspectiva filosófica
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Navarrete, Rivas José Luis. "“TOM Gunn’s poetry: A question of male afecction”, “La poesía de TOM Gunn: Una pregunta en torno a la afectividad masculina” (versión en español)." Tesis, Universidad de Chile, 2002. http://repositorio.uchile.cl/handle/2250/110064.
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El objetivo del trabajo es presentar rasgos temáticos y estilísticos de la poesía de Thom Gunn. Este es un poeta británico y lo he elegido por su prolífica obra, en la cual se integran temáticas culturales y políticas como parte de su carrera como poeta. Desde sus comienzos como estudiante de Cambridge, "de algún modo, el carácter y la máscara de los poemas de Gunn es lo que Christopher Isherwood definió como "El Hombre Realmente Débil", que siempre toma una vía circular y más peligrosa porque no puede enfrentarse a decisiones tajantes que lo lanzarían a un viaje mucho más directo. Estas consideraciones hacen que Gunn sea un poeta sumamente interesante desde una perspectiva filosófica
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Giacalone, Marco. "Development of qualification procedures for DRM2 acquisition boards of the ALICE-TOF detector." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2018. http://amslaurea.unibo.it/17075/.
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Il lavoro di questa tesi è inserito nel contesto del programma di upgrade previsto per l'esperimento ALICE durante lo spegnimento della macchina acceleratrice nel biennio 2019-2020 (Long Shutdown 2).
A partire dal 2021 è prevista in ALICE la registrazione di dati a un rate di interazione maggiore rispetto al passato sia in collisioni pp (fino a 200 kHz) che in eventi Pb-Pb (fino a 50 kHz). Oltre al rinnovo di alcuni detector (tracciatore al silicio e TPC), andranno
potenziati gli attuali sistemi di readout per permettere un readout continuo senza preselezione di eventi.
Nello specifico l'attività svolta per questa tesi è legata al collaudo e allo sviluppo dei nuovi Data Readout Module (DRM2) che andranno a sostituire i precedenti componenti nel rivelatore a tempo di volo (TOF) dell'esperimento.
Per monitorare le funzionalità della scheda è stata sviluppata una GUI (Graphical user interface) che permette la lettura e scrittura di tutti i registri interni della scheda e anche la programmazione del principale ASIC in uso da essa (il chip GBTx che implementa
un ricevitore/trasmettitore a 4.8 Gbit/s). Tale procedura è importante perchè permette al GBTx di programmarsi all'accensione della scheda nella configurazione richiesta.
Poiché la scheda sarà esposta in ambiente radiativo moderatamente ostile (TID = 0.13 krad in 10 anni), sono stati effettuati dei test presso il Centro di Prototerapia di Trento con un fascio di protoni di 100 MeV di energia ad alta intensità su alcuni componenti chiave (FPGA Microsemi Igloo2 e transceiver ottici della AVAGO). Vengono discussi i risultati in termini di resistenza alla dose totale assorbita, di sezione d'urto per Single
Event Upset (SEU) e Latchup (SEL).
Al fine di sviluppare un sistema di test-bench compatto della scheda è stata infine sviluppata un'applicazione per consentire il collegamento via LAN attraverso protocollo UDP per monitorare i dati ricevuti attraverso il link GBTx dalla DRM2 con una scheda di
sviluppo della Xilinx.
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Yolka, Philippe. "La propriété publique : éléments pour une théorie /." Paris : LGDJ, 1997. http://www.gbv.de/dms/spk/sbb/recht/toc/272694053.pdf.
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Musolino, Mattia. "Growth, fabrication, and investigation of light-emitting diodes based on GaN nanowires." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17409.
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Diese Arbeit gibt einen tiefgehenden Einblick in verschiedene Aspekte von auf (In,Ga)N/GaN Heterostrukturen basierenden Leuchtdioden (LEDs), mittels Molekularstrahlepitaxie entlang der Achse von Nanodrähten (NWs) auf Si Substraten gewachsen. Insbesondere wurden die Wachstumsparameter angepasst, um eine Koaleszierung der Nanodrähte zu vermindern. Auf diese Weise konnte die durch die NW-LEDs emittierte Intensität der Photolumineszenz (PL) um einen Faktor zehn erhöht werden. Die opto-elektronischen Eigenschaften von NW-LEDs konnten durch die Verwendung von Indiumzinoxid, anstatt von Ni/Au als Frontkontakt, verbessert werden. Zudem wurde demonstriert, dass auch selektives Wachstum (SAG) von GaN NWs auf AlN gepufferten Si Substraten mit einer guten Leistungsfähigkeit von Geräte vereinbar ist und somit als Wegbereiter für eine neue Generation von NW-LEDs auf Si dienen kann. Weiterhin war es möglich, strukturierte Felder von ultradünnen NWs durch SAG und thermische in situ Dekomposition herzustellen. In den durch die NW-LEDs emittierten Elektrolumineszenzspektren (EL) wurde eine Doppellinenstruktur beobachtet, die höchstwahrscheinlich von den kompressiven Verspannungen im benachbarten Quantentopf, durch die Elektronensperrschicht verursachten, herrührt. Die Analyse von temperaturabhängigen PL- und EL-Messungen zeigt, dass Ladungsträgerlokalisierungen nicht ausschlaggebend für die EL-Emission von NW-LEDs sind. Die Strom-Spannungs-Charakteristiken (I-V) von NW-LEDs unter Vorwärtsspannung wurden mittels eines Modells beschrieben, in das die vielkomponentige Natur der LEDs berücksichtigt wird. Die unter Rückwärtsspannung aktiven Transportmechanismen wurden anhand von Kapazitätstransientenmessungen und temperaturabhänigigen I-V-Messungen untersucht. Dann wurde ein physikalisches Modell zur quantitativen Beschreibung der besonderen I-V-T Charakteristik der untersuchten NW-LEDs entwickelt.This PhD thesis provides an in-depth insight on various crucial aspects of light-emitting diodes (LEDs) based on (In,Ga)N/GaN heterostructures grown along the axis of nanowires (NWs) by molecular beam epitaxy on Si substrates. In particular, the growth parameters are adjusted so as to suppress the coalescence of NWs; in this way the photoluminescence (PL) intensity emitted from the NW-LEDs can be increased by about ten times. The opto-electronic properties of the NW-LEDs can be further improved by exclusively employing indium tin oxide instead of Ni/Au as top contact. Furthermore, the compatibility of selective-area growth (SAG) of GaN NWs on AlN-buffered Si substrates with device operation is demonstrated, thus paving the way for a new generation of LEDs based on homogeneous NW ensembles on Si. Ordered arrays of ultrathin NWs are also successfully obtained by combining SAG and in situ post-growth thermal decomposition. A double-line structure is observed in the electroluminescence (EL) spectra emitted by the NW-LEDs; it is likely caused by compressive strain introduced by the (Al,Ga)N electron blocking layer in the neighbouring (In,Ga)N quantum well. An in-depth analysis of temperature dependent PL and EL measurements indicates that carrier localization phenomena do not dominate the EL emission properties of the NW-LEDs. The forward bias current-voltage (I-V) characteristics of different NW-LEDs are analysed by means of an original model that takes into account the multi-element nature of LEDs based on NW ensembles by assuming a linear dependence of the ideality factor on applied bias. The transport mechanisms in reverse bias regime are carefully studied by means of deep level transient spectroscopy (DLTS) and temperature dependent I-V measurements. The physical origin of the detected deep states is discussed. Then, a physical model able to describe quantitatively the peculiar I-V-T characteristics of NW-LEDs is developed.
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Heppel, Sabine Sigrid. "Optische Verstärkung und Wellenleitung in GaInN/GaN-Laserstrukturen /." Tönning [u.a.] : Der Andere Verlag, 2008. http://www.gbv.de/dms/bs/toc/567019411.pdf.
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Topp, Stefan. "Qualifikationsattribute von Hegemonialmächten : internationale und innerstaatliche Voraussetzungen der Bereitstellung internationaler Kollektivgüter durch hegemonial geführte Kooperationsstrukturen /." Frankfurt am Main [u.a.] : Lang, 2002. http://www.gbv.de/dms/bs/toc/353324728.pdf.
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Larsson, Mikael. "A Visualization Tool for Drill Rig Simulators used in Software Development." Thesis, Örebro University, School of Science and Technology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-10313.
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Boomer is a machine that is developed and produced by Atlas Copco Rock Drills AB, which is used for underground mining and tunneling. It is a blast-hole drilling rig equipped with drills that are attached to the arms, called booms, which the rig holds. The machine is controlled and monitored by Atlas Copco’s Rig Control System (RCS), which consists of a number of intelligent units connected in a CAN-net. When developing software for the RCS, a simulator that makes it possible to run the software on an ordinary desktop PC is used. The problem is that there is no intuitive way to see how the booms are oriented, while positioning. Therefore it is desirable to have a 3D visualization of the rig, with focus on the booms, which can be used alongside the simulator to get immediate feedback about the movements of the booms. This report describes the process of developing an application that handles communication with the simulator and the 3D visualization.
Boomer är en maskin som utvecklas och produceras av Atlas Copco Rock Drills AB. Maskinen används vid gruvbrytning och tunnelkonstruktion. Boomer är en spränghålsborrigg som är utrustad med borrar vilka är monterade på riggens armar, kallade bommar. En Boomer övervakas och kontrolleras av Atlas Copcos kontrollsystem, RCS, som är ett system bestående av intelligenta enheter sammankopplade i ett CAN-nät. Vid utveckling av mjukvara till RCS används en simulator som gör det möjligt att köra mjukvaran på en vanlig PC. Problemet är att det inte finns något intuitivt sätt att se hur bommarna är riktade medans de blir positionerade. Därför är det önskvärt med en 3D visualisering av borriggen, med fokus på dess boomar, som kan användas tillsammans med simulatorn för att ge en direkt återkoppling av boomarnas förflyttning. Denna rapport beskriver utvecklingsprocessen för en applikation som hanterar kommunikationen med simulatorn och 3D visualiseringen.
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Leal, Beraldo Costa. "Uma arquitetura hierárquica baseada em sistema de arquivos para monitoramento de pacotes de rede no sistema operacional GNU/Linux." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/45/45134/tde-19122013-113710/.
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Capturar e analisar pacotes de dados que trafegam pelas redes são tarefas essenciais para os administradores de redes. Estas tarefas ajudam na detecção de anomalias nos sistemas e na verificação do estado atual da rede. Existem várias aplicações que desempenham este papel para o sistema operacional GNU/Linux. Estes programas também exportam informações para os usuários e outras aplicações de várias maneiras. Entretanto, não exportam estas informações de forma hierárquica. Esta pesquisa propõe uma arquitetura alternativa aos sistemas atuais. Nossa arquitetura exporta pacotes de dados em uma estrutura hierárquica de arquivos e diretórios. Além disso, por se tratar de uma arquitetura modular, filtros adicionais, desenvolvidos por terceiros, podem ser adicionados ao sistema. A arquitetura proposta acompanha uma implementação de referência: o sistema de arquivos virtuais netsfs (Network Statistics File System), que funciona em espaço de núcleo (kernel space). A arquitetura e o sistema de arquivos netsfs, propostos nesta pesquisa, apresentam um método alternativo para exibir os pacotes de redes. Os resultados mostraram uma aparente melhoria no que diz respeito à vazão da rede.Capturing and analyzing data packets flowing across networks are essential tasks for network administrators. These tasks help to detect anomalies in the systems and check the current status of a network. There are software applications for the GNU/Linux operating system which perform such tasks. These tools also export their information to users and other applications in different ways. However, current systems do not export this information in a hierarchical manner. This research introduces an alternative architecture to current systems. Our architecture exports data packets in a hierarchical structure of directories and files. Furthermore, since this is a modular architecture, additional third-party filters can be developed and loaded into the system. The proposed architecture comes with a reference implementation: the pseudo file system netsfs (Network Statistics File System), in kernel space. The architecture and the pseudo file system netsfs, developed in this research, introduce an alternative method to display data packets. Results show an apparent improvement regarding network throughput
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Bitar, Fouad. "Les mouvements transfrontières de déchets dangeroux selon la convention de Bâle : étude des régimes de responsabilité /." Paris : Pedone, 1997. http://www.gbv.de/dms/spk/sbb/recht/toc/273361929.pdf.
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Dhameri, Sulaiman Ali A. "Rheological Properties and Decomposition Rates of Gellan Gum." University of Toledo / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1562780919692096.
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Karpenstein, Ulrich. "Europäisches Exportkontrollrecht für Dual-use-Güter /." Stuttgart ;München ;Hannover ;Berlin ;Weimar ;Dresden : Boorberg, 1998. http://www.gbv.de/dms/spk/sbb/recht/toc/279254199.pdf.
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Montanari, Simone. "Fabrication and characterization of planar Gunn diodes for Monolithic Microwave Integrated Circuits /." Jülich : Forschungszentrum Jülich, 2005. http://www.loc.gov/catdir/toc/fy0610/2006364266.html.
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Alexandrow, Ilja. "Internationale Schiedsgerichtsbarkeit in Deutschland und in den GUS-Staaten /." Berlin : dissertation.de, 2003. http://www.gbv.de/dms/spk/sbb/recht/toc/368061361.pdf.
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Ferrari, Ilse Fernanda. "Caracterização de promotores de expressão especifica de cana-de-açucar (Saccharum ssp.) em sistema modelo Micro-Tom (Solanum lycopersicum L)." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/64/64133/tde-18012013-145236/.
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O emprego de novas tecnologias, como a transgenia, associadas ao melhoramento convencional de cana-de-açúcar apresenta grande potencial no combate a pragas e desenvolvimento de novas variedades. Entretanto, a falta de especificidade na expressão temporal e/ou local dos genes introduzidos tem se mostrado um fator limitante para o sucesso de produtos derivados da transgenia. Os promotores das metalotioneínas, por exemplo, podem representar uma alternativa ao uso de promotores constitutivos, particularmente, aqueles de metalotioneínas do tipo 1 (MT1) por apresentarem níveis elevados de expressão, em diferentes tecidos/órgãos e serem responsivos a estresses bióticos e abióticos. O uso de promotores sintéticos, contendo apenas elementos-cis, como GCG-like, W boxes e JERE, tem sido relevante por induzirem a expressão gênica local em resposta ao ataque de agentes bióticos. Este trabalho teve por objetivo a caracterização funcional de promotores de genes de metalotioneínas de cana-de-açúcar e o uso de elementos regulatórios sintéticos e, em paralelo, avaliou-se o uso de promotores sintéticos no controle da expressão gênica em cana-de-açúcar. Após as análises de expressão transiente, verificou-se que o promotor SoMT1b apresentou atividade GUS e GFP em epitélios de cebola e os promotores sintéticos, 4X Wbox, 4X GCC-like, 4X JERE e 4xW 4xS-box, e o promotor SoMT1b foram capazes de dirigir a expressão do gene repórter uidA (GUS) em calos embriogênicos de cana-de-açúcar. Em análise de expressão estável, o promotor SoMT1b foi capaz de dirigir a expressão do gene GUS para os frutos e sementes de tomate \'Micro-Tom\', mas não foi responsivo a estresse por herbivoria, cádmio e cobre. Também foi realizada a transformação de plantas de cana-de-açúcar, as quais ainda estão sendo analisadas. Os resultados obtidos demonstram a funcionalidade do promotor SoMT1bNew technologies, like genetic transformation, associated with conventional breeding of sugarcane have a large potential in developing new varieties tolerant to biotic and abiotic stress. However, the lack of specificity in the spatial and/or temporal expression of the introduced genes has been a limited factor for the success of products derived from transgeny. Metallothionein promoters, for instance, can represent an alternative to the use of constitutive promoters, particularly those from metallothionein type 1 (MT1) because they present high expression levels in different tissues / organs and are responsive to biotic and abiotic stress. Another alternative is the use of synthetic promoters which contain only cis elements, as GCG-like, W-box and JERE, which induces local gene expression in response to pathogen attack. In this work, we aimed to make the functional characterization of sugarcane metallothionein promoters and synthetic regulatory elements, in parallel, we evaluated the use of synthetic promoters in the control of gene expression in sugarcane. After transient expression analyzis, it was found that SoMT1b promoter was able to control the expression of the reporter genes to GUS and GFP in onion epithelium and GUS in sugarcane embryogenic calli. Additionally, synthetic promoters 4X Wbox, 4X GCC-like, 4X JERE and 4xW 4xS-box were able to direct the expression of the gene uidA (GUS) in embryogenic calli of sugarcane. In stable transformation analysis, SoMT1b promoter was capable of directing uidA expression in fruits and seeds of tomato cv. \'Micro-Tom\', but it was not responsive to herbivory, cadmium and copper stress. It was also carried out the transformation of sugarcane plants with the construction containing the SoMT1b promoter, but these are still being analyzed. The results demonstrate the functionality of the SoMT1b promoter in sugarcane and tomato
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Paix?o, Marcus Vinicius Gomes. "Aplica??o de g?is de goma guar no processo de clarifica??o de salmouras e ?guas produzidas." Universidade Federal do Rio Grande do Norte, 2015. http://repositorio.ufrn.br/handle/123456789/20014.
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A ?gua produzida ? considerada o principal efluente da ind?stria do petr?leo, em fun??o do seu volume crescente nos campos maduros e de sua composi??o variada. O teor de ?leos e graxas (TOG) ? considerado o principal par?metro para o descarte final da ?gua produzida. Diante desse contexto, ? de grande relev?ncia o desenvolvimento de um m?todo alternativo ? base de g?is de goma guar para o tratamento de ?guas produzidas sint?ticas, tendo como diferencial a utiliza??o de um pol?mero com elevada hidrofilicidade para a clarifica??o de ?guas contaminadas com petr?leo. Dessa forma, este trabalho tem como objetivo avaliar a efici?ncia de g?is de goma guar na remo??o do ?leo presente em ?guas produzidas. A goma guar ? um pol?mero natural que, em condi??es espec?ficas, forma estruturas tridimensionais, com importantes propriedades f?sico-qu?micas. Atrav?s da reticula??o das cadeias polim?ricas por ?ons borato, na presen?a de sais, ocorre o efeito salting out, reduzindo a solubilidade do gel polim?rico em ?gua. Como resultado, tem-se a separa??o das fases com o ?leo aprisionado no gel colapsado. O TOG foi quantificado a partir da espectroscopia na regi?o do ultravioleta e vis?vel. O sistema desenvolvido mostrou-se altamente eficiente na remo??o de petr?leo disperso em ?gua produzida sint?tica, atingindo porcentagens de remo??o superiores a 90%.
Produced water is considered the main effluent of the oil industry, due to their increased volume in mature fields and its varied composition. The oil and grease content (TOG) is the main parameter for the final disposal of produced water. In this context, it is of great significance to develop an alternative method based on guar gum gel for the treatment of synthetic produced water, and using as the differential a polymer having high hydrophilicity for clarifying waters contaminated with oil. Thus, this study aims to evaluate the efficiency of guar gum gels in the remotion of oil from produced water. Guar gum is a natural polymer that, under specific conditions, forms three-dimensional structures, with important physical and chemical properties. By crosslinking the polymer chains by borate ions in the presence of salts, the effect salting out occurs, reducing the solubility of the polymer gel in water. As a result, there is phase separation with the oil trapped in the collapsed gel. The TOG was quantified from the spectroscopy in the ultraviolet and visible region. The system was proven to be highly efficient in the removal of dispersed oil from water produced synthetically, reaching removal percentages above 90%.
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Takada, Leonel Tadao. "Pesquisa de mutações do gene GRN e dosagem plasmática de progranulina em casuística brasileira de degeneração lobar frontotemporal." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5138/tde-11092015-154947/.
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Introdução: A demência frontotemporal (DFT) inclui a variante comportamental da demência frontotemporal (vcDFT), a variante semântica da afasia progressiva primária (vsAPP), e a variante não fluente da APP (vnfAPP). Os genes em que são encontradas mutações causadoras de DFT mais frequentemente são: GRN (que codifica a progranulina), MAPT (que codifica a proteína tau) e C9orf72. Métodos: Foram incluídos probandos diagnosticados com vcDFT, vsAPP ou vnfAPP, com base com os critérios diagnósticos mais recentes, e um grupo de indivíduos cognitivamente normais. Os éxons 2-12 de GRN e os éxons 1, 9-13 de MAPT foram sequenciados pelo método de Sanger, e foi realizada dosagem de progranulina no plasma. Resultados: foram incluídos 62 probandos, sendo 44 com vcDFT, 9 com vsAPP, e 9 com vnfAPP. Antecedente familiar de demência foi positivo em 45,1% dos probandos, e de DFT, em 24,1%. Os 60 indivíduos do grupo controle tinham idade média de 60,8±8,5 anos. Foram identificadas seis mutações nulas em GRN (p.Q130X, p.V200Gfs*18, p.Q257Pfs*26, p.Q300X, p.S301Cfs*60 e p.D317Afs*11) e uma mutação patogênica em MAPT (p.N279K). A dosagem média de progranulina plasmática nos pacientes com mutações de GRN foi de 29,8±11,9ng/ml Conclusões: A frequência de mutações patogênicas em GRN nesta casuística foi de 9,6%, e a de mutações em MAPT foi de 1,6%. Entre casos familiais de DFT, a frequência de mutações em GRN foi de 33,3%, e em MAPT foi de 6,7%. Duas das mutações encontradas em GRN (p.Q130X e p.D317Afs*11) ainda não foram descritas em casos de DFT. O valor de corte de 70ng/ml identificou as mutações nulas de GRN com sensibilidade e especificidade de 100%Introduction: Frontotemporal dementia (FTD) encompasses behavioral variant of frontotemporal dementia (bvFTD), semantic variant of primary progressive aphasia (svPPA), and nonfluent variant PPA (nfvPPA). The genes in which FTD-causing mutations are most frequently found are: GRN (which encodes progranulin), MAPT (which encodes tau protein) and C9orf72. Methods: We included probands diagnosed with bvFTD, svPPA or nfvPPA, based on the most recent diagnostic criteria, and a group of cognitively normal individuals. GRN exons 2-12 and MAPT exons 1, 9-13 were sequenced by the Sanger method, and plasma progranulin levels were measured. Results: we included 62 probands (44 with bvFTD, 9 with svPPA, and 9 with nfvPPA). Family history of dementia was positive in 45.1% of probands, and of DFT, in 24.1%. The control group of 60 individuals had a mean age of 60.8±8.5 years. Six null GRN mutations were identified in (p.Q130X, p.V200Gfs*18, p.Q257Pfs*26, p.Q300X, p.S301Cfs*60 e p.D317Afs*11) and one MAPT pathogenic mutation (p.N279K). The mean plasma progranulin level in patients with GRN mutations was 29.8±11,9ng/ml. Conclusions: The frequency of pathogenic mutations in GRN was 9.6%, and of MAPT mutations was 1.6%. Among cases of familial FTD, the frequency of GRN mutations was 33.3%, and of MAPT mutations was 6.7%. Two of the mutations found in GRN (p.Q130X and p.D317Afs*11) are novel. The cutoff value of 70ng/ml identified null GRN mutations with sensitivity and specificity of 100%
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Wu, Chengquan. "Han mo Wei Jin Nan Bei chao dao jiao jie lü gui fan yan jiu /." Chengdu Shi : Sichuan chu ban ji tuan Ba Shu shu she, 2006. http://www.loc.gov/catdir/toc/chi0801/2008553894.html.
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Ngom, Issa Isaac. "Exploration du microbiote digestif par des approches multi-OMICS." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0582.
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L’intestin humain est colonisé par un grand nombre de microorganismes qui ont des associations intimes avec notre organisme. L’application de technologies de séquençage à haut débit a permis d’identifier un grand nombre de membres de la communauté tant au niveau phylogénétique qu’au niveau du métagénome. Ce dernier a permis de définir un ensemble de référence de plusieurs millions de gènes principalement bactériens et a servi de base à l'élaboration d'approches omiques permettant de cibler la taxonomie, l'activité et la fonction du microbiome humain. La disponibilité d'informations exhaustives sur le génome de nombreux microbes, y compris des espèces non cultivables dans des écosystèmes microbiens complexes tels que l’intestin ont fourni un moyen d’accéder à des informations génomique, transcriptomique et protéomique. La métaprotéomique, basée sur la puissance de la spectrométrie de masse à haute performance, permet d’effectuer la caractérisation à grande échelle de protéines issues du microbiote intestinal. Dans cette thèse nous nous sommes appesanti en premier sur les stratégies et applications de la métaprotéomique dans la recherche microbienne intestinale en présentant ses limites et défis dans l’ère des méta-omiques. Ensuite, nous avons montré dans la seconde partie qu’une intégration des données de culturomique, de métagénomique et de métaprotéomique permet d’avoir une vision exhaustive sur la cartographie taxonomique microbienne de l’intestin. L’utilisation de la culturomique dans cette partie a permis d’augmenter 19 nouvelles espèces bactériennes dans le répertoire du microbiote intestinal dont 7 sont décrites dans la dernière partie de ce travailThe human gut is colonized by many microorganisms that are closely associated to the human body. Culture-based approaches have provided a better understanding of the complexity of these microbial communities. However, the application of high-throughput sequencing technologies has identified large numbers of community members at both the phylogenetic and the metagenome level. The latter has allowed us to define a set of several millions of references genes, mainly bacterial genes and provided the basis for developing approaches that target the taxonomy, activity and function of the human microbiome. The availability of extensive genome information for many different microbes, including unculturable species in complex microbial ecosystems such as the gut, has provided a means of accessing genomic, transcriptomic and proteomic information. Therefore, the metaproteomics, based on the power of high-performance mass spectrometry, allow the large-scale characterization of intestinal microbiota proteins. Moreover, it becomes a complementary approach to metagenomic data.In this thesis, we first focused on the strategies and applications of metaproteomics in intestinal microbial research, presenting its limits and challenges in the era of meta-omics. Secondly, we showed that, an integration of the culturomics, metagenomics and metaproteomics data provides a comprehensive and complementary view of microbial taxonomic mapping of the intestine. The application of the culturomics in this part has allowed to increase 19 new bacterial species in the repertoire of gut microbiota of which, 7 are described in the last part of this work
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Cherng, Jong-Yuh. "Pharmaceutical aspects of polymer-based gene delivery systems : preparation, characterization and stabilization = Toedieningsvormen voor gen-therapeutika vanuit farmaceutisch perspectief /." Leiden : OctoPlus, 1999. http://www.gbv.de/dms/bs/toc/300313977.pdf.
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Cherng, Jong-Yuh. "Pharmaceutical aspects of polymer-based gene delivery systems : preparation, characterization and stabilization = Toedieningsvormen voor gen-therapeutica vanuit farmaceutisch perspectief /." [S.l. : s.n.], 1999. http://www.gbv.de/dms/bs/toc/300313977.pdf.
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Dione, Niokhor. "Exploration du microbiote digestif : stratégies de culture des bactéries anaérobies et de culture difficile." Thesis, Aix-Marseille, 2017. http://www.theses.fr/2017AIXM0614.
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Le microbiote digestif, composé de 1012 à 1014 bactéries par gramme de selle, est dominé par les bactéries anaérobies. Ces dernières, qui dépassent largement les aérobies, ont été découvertes en 1865 par Louis Pasteur dans ses travaux sur la fermentation. Les bactéries anaérobies représentent un intérêt médical particulier par leur implication dans les maladies infectieuses et métaboliques. Les anaérobies sont caractérisés par leur difficulté à être cultivés, car nécessitant une absence ou des concentrations faibles d’oxygène. Ainsi les connaissances sur ces microorganismes étaient limitées. Cependant, avec l’avènement des outils de biologie moléculaire notamment le séquençage à haut débit et le concept culturomics associé à l’identification par spectrométrie de mass MALDI-TOF, la connaissance des microorganismes anaérobies a été accentuée. Dans ce travail, nous nous sommes attelés dans un premier temps à la mise au point d’un milieu de culture efficace pour la culture des bactéries anaérobies et les tests d’activités antimicrobiennes. Nous avons montré dans un deuxième temps que culturomics, associé au MALDI-TOF, était un outil puissant dans l’identification des bactéries anaérobies en microbiologie clinique, mais également dans l’exploration de la diversité microbienne du tube digestif. Cette technique nous a permis d’isoler 19 nouvelles espèces de bactéries anaérobies dont 9 ont été décrites dans la troisième partie de ce travailThe human gut microbiota is known to contain around 1012 to 1014 bacteria per gram of feces, with the majority being anaerobic. The latters were first discovered in 1865 by Louis Pasteur while working on fermentation. Anaerobic bacteria are known to play an important role in health and diseases and thus have taken a lot of attention in the medical field, especially in infectiousdiseases and metabolism. These bacteria are known for its sophisticated culture system because its growth requires little to no oxygen. Nevertheless, few is known about these type of microorganisms but with the advancement of molecular biology and sequencing techniques, its study became wider. Culturomics, is a recently developed culture-based approach that relies on optimizing culture conditions for bacterial growth and its identification by MALDI-TOF MS and 16S rRNA sequencing. The present work aims to create and optimized culture condition for anaerobic bacteria along with testing its anaerobic activities. Also, we aim to demonstrate the efficiency of Culturomics and MALDI-TOF in culturing, identifying and describing anaerobic bacteria in clinical microbiology and in the human gut. This approach allowed us to isolate 19 new anaerobic species out of which 9 has been described in this work.Keywords: Human gut microbiota, culture of anaerobic bacteria, culturomics, MALDI-TOF
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Ha, Thi Quyen. "Analysis of gene encoding haemolysin A of Vibrio cholerae isolated in Vietnam." Technische Universität Dresden, 2018. https://tud.qucosa.de/id/qucosa%3A33123.
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Vibrio cholerae is the cholera causing agent, divided into two biotypes, including the classical biotype and ElTor biotype. Both of these biotypes caused cholera epidemics in the world. The classical biotype caused 6th cholera pandemic (from 1921 to 1961), and ElTor biotype caused 7th cholera pandemic (from 1961 to the 70s). Haemolysin A, a hemolytic protein of V. cholerae ElTor biotype, is encoded by the hlyA gene. This gene is often used for analyzing genetic relationship between strains in the same species or between species in the same Vibrio genus. Results of analyzing nucleotide and amino acid sequences of hlyA gene of V. cholerae strain causing cholera in Vietnam (named hlyA.VN) showed that: the hlyA.VN gene sequence was similar to the hlyA gene sequences of V. cholerae strains of the 6thand 7thcholera epidemics. The hlyA gene of the 6th cholera epidemic strain was deficient in 11 nuleotides (this deficiency leading to the loss of 4 amino acids in the haemolysin A protein) comparing to hlyA.VN gene and hlyA gene of the 7th cholera epidemic strain. The results of genetic distance analysis as well as phylogenetic tree construction also confirmed V. cholerae causing cholera in Vietnam was closely relationship to the strains causing cholera pandemics in the world. It is great significance for the surveillance of molecular epidemiology to prevent cholera effectively.Vibrio cholerae là tác nhân gây bệnh tả, được chia thành hai typ sinh học, đó là typ sinh học cổ điển và typ sinh học ElTor. Cả hai typ này đã từng gây ra các đại dịch tả trên thế giới. Typ sinh học cổ điển đã từng gây ra đại dịch tả lần thứ 6 (từ năm 1921 đến 1961), còn typ sinh học ElTor đã từng gây ra đại dịch tả lần thứ 7 (từ 1961 đến những năm 70). Haemolysin A, một protein có chức năng làm tan máu của V. cholerae typ sinh học ElTor, được mã hóa bởi gen hlyA. Gene này thường được sử dụng cho các phân tích quan hệ di truyền giữa các chủng trong cùng một loài V. cholerae hay giữa các loài trong cùng một chi Vibrio. Kết quả phân tích trình tự nucleotide và axit amin gen hlyA của chủng V. cholerae gâybệnh ở Việt Nam (hlyA.VN) cho thấy: trình tự gen hlyA.VN có sự tương đồng lớn với trình tự gen hlyA của chủng gây đại dịch tả 6 và 7. Gen hlyA của chủng gây đại dịch tả 6 bị thiếu hụt 11 nuleotide (sự thiếu hụt này dẫn tới sự mất đi 4 axit amin trong phân tử haemolysin A) so với gen hlyA.VN và gene hlyA của chủng gây đại dịch tả 7. Kết quả phân tích khoảng cách di truyền cũng như xây dựng cây phát sinh chủng loại cũng đã khẳng định: chủng gây bệnh ở Việt Nam có quan hệ rất gần với các chủng gây đại dịch tả trên thế giới. Nhận định này có ý nghĩa rất lớn đối với công tác giám sát dịch tễ học phân tử để ngăn chặn bệnh tả hiệu quả.
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Laird, Daniel T. "OPERATOR INTERFACES FOR CONTROLLING THE SERIAL STREAMING TELEMETRY CHANNEL VIA A COMMAND AND CONTROL LINK." International Foundation for Telemetering, 2007. http://hdl.handle.net/10150/604402.
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ITC/USA 2007 Conference Proceedings / The Forty-Third Annual International Telemetering Conference and Technical Exhibition / October 22-25, 2007 / Riviera Hotel & Convention Center, Las Vegas, NevadaThe Central Test and Evaluation Incentive Program, (CTEIP) is developing Integrated Network Enhanced Telemetry (iNET) to extend serial streaming telemetry (SST) with a command and control link. Command link interfaces link remote Advanced Range Telemetry (ARTM) transmitters (Tx) and receivers (Rx), developed under the ARTM CTEIP project, via graphical user interfaces (GUI). The communication channel links the iNET Tx on a vehicle network (vNET) and the iNET Rx on a ground station network (gNET) via a single GUI. The command link is an essential part of the pending iNET Technology Demonstration.
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Timme, Michael. "Die juristische Bewältigung eines ökonomischen Netzwerkgutes : Epidemieprävention in Rechtsgeschichte und Gegenwart /." Baden-Baden : Nomos-Verl.-Ges, 2001. http://www.gbv.de/dms/spk/sbb/recht/toc/322844924.pdf.
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Degenhardt, Tom [Verfasser], and Nadia [Akademischer Betreuer] Harbeck. "Prospektiver Vergleich der Invasionsfaktoren uPA/PAI-1 und des 21-Gen-Tests OncotypeDX® im Rahmen der WSG Plan-B Studie / Tom Degenhardt. Betreuer: Nadia Harbeck." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1110748930/34.
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Moestl, Michaela. "EU: Kompetenzabgrenzung zwischen Gemeinschafts- und Unionspolitiken : dargestellt am Beispiel der Ausfuhrkontrolle von Gütern mit doppeltem Verwendungszweck (Dual-use-Gütern) /." Wien : Landesverteidigungsakad, 2004. http://www.gbv.de/dms/spk/sbb/recht/toc/482774223.pdf.
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Million, Matthieu. "Caractérisation des altérations du microbiote digestif associées à l'obésité et rôle de la manipulation du microbiote digestif dans l'obésité." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5024.
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L'avènement des méthodes de séquençage moléculaire à large échelle a permis l'identification d'altérations du microbiote digestif spécifiquement associés à l'obésité notamment un ratio Bacteroidetes/Firmicutes diminué chez les obèses. Depuis, de nombreux travaux ont décrit de nouvelles altérations associées à l'obésité, notamment une augmentation des représentants du genre Lactobacillus mais l'ensemble de ces résultats sont souvent l'objet de controverses. Afin de clarifier si le genre Lactobacillus était associé à l'obésité, nous avons réalisé deux études cas témoins (la deuxième étant le prolongement de la première avec un effectif de 263 individus) qui nous ont permis d'identifier que les altérations du microbiote digestif sont plus reproductibles au niveau de l'espèce. A ce titre nous avons retrouvé une plus grande concentration de Lactobacillus reuteri dans le microbiote digestif de sujets obèses alors que les concentrations de Bifidobacterium animalis, Methanobrevibacter smithii et Escherichia coli étaient diminuées. Nous avons pu établir une relation dose-dépendante entre la concentration de Lactobacillus reuteri et l'indice de masse corporelle. Par ailleurs, nous avons réalisé une méta-analyse sur les résultats des études publiées et avons retrouvé une association entre les genres Bifidobacterium (6 études, 348 individus) et Methanobrevibacter (3 études, 195 individus) avec l'absence d'obésité (…)The revolution of large scale molecular sequencing methods allowed the identification of specific alterations in the gut microbiota associated with obesity such as a decreased Bacteroidetes / Firmicutes ratio in obese individuals. Since then, many studies have described different alterations associated with obesity, including an increase in members of the Lactobacillus genus, but results are often controversial. To clarify whether the genus Lactobacillus was associated with obesity, we conducted two case-control studies (the second being the follow-up of the first study with a total of 263 individuals) allowing us to understand that gut microbiota alterations are more reproducible at the species level. We found a greater concentration of Lactobacillus reuteri in the gut microbiota of obese while concentrations of Bifidobacterium animalis, Methanobrevibacter smithii and Escherichia coli were reduced. We were able to establish a dose-dependent relationship between the concentration of Lactobacillus reuteri and body mass index. In addition, we performed a meta-analysis on the results of published studies and we found an association between the Bifidobacterium (6 studies, 348 individuals) and Methanobrevibacter (3 studies, 195 individuals) with absence of obesity. (…)
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Karlovský, Juraj. "Příprava řezů vzorků a jejich analýza metodou SIMS." Master's thesis, Vysoké učení technické v Brně. Fakulta strojního inženýrství, 2018. http://www.nusl.cz/ntk/nusl-382254.
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This thesis studies possible methods of semiconductor sample measurement by SIMS, with emphasis on testing different measurement parameters and sample preparation. Part of this master thesis deals with the design of a modified sample holder compatible with the used ToF-SIMS$^{5}$ instrument, IONTOF company, which is capable of tilting the sample by defined angle. This holder enables sample preparation in the main chamber of the instrument without the need of transferring the sample between instruments, which limits the probability of sample contamination. This sample holder was tested by ion machining of TIGBT sample edge and by imaging of a crater edge, created in previous measurement. Edge termination structures prepared by different techniques were measured on the TIGBT samples. Further measurements with the goal of optimizing the depth resolution for thin layers were done on Molybdenum-Silicon-multilayer X-Ray Mirror. Part of the measurements was focused on comparing depth profiles measured at low temperatures. For these measurements the samples with Indium multilayers in GaN substrate were used.
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Pinheiro, Beliza Maria de Souza. "Avalia??o dos poss?veis impactos da atividade salineira atrav?s do monitoramento da qualidade da ?gua e sedimento do estu?rio Tom?s-Galinhos em Galinhos/RN." PROGRAMA DE P?S-GRADUA??O EM QU?MICA, 2016. https://repositorio.ufrn.br/jspui/handle/123456789/23386.
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O Rio Grande do Norte ? o maior produtor de sal, cloreto de s?dio, do pa?s e detentor de 97% de todo o sal produzido. Nesse contexto, a Salina Diamante Branco - SDB, em Galinhos, descarta toda a salmoura de processo na ?rea estudada, o rio Tom?s-Galinhos. Desse modo, ? essencial avaliar os poss?veis impactos dessa atividade salineira no corpo d??gua adjacente. Dessa forma, realizou-se um monitoramento f?sico-qu?mico da qualidade de ?gua e sedimento para obten??o de um diagn?stico ambiental, incluindo os indicadores de polui??o, o ?ndice de Qualidade de ?gua ? IQA e o ?ndice de Toxicidez. A maioria das amostras foram coletadas de julho de 2014 a abril de 2016, trimestralmente, em um total de 32 coletas em mar? alta e baixa. Al?m dessas coletas, houveram mais duas de metais pesados em ?gua e sedimento. Todos os resultados foram relacionados com os padr?es exigidos pelas resolu??es 357, de 17 de mar?o de 2005 e 344, de 25 de mar?o de 2004, ambas, do Conselho Nacional do Meio Ambiente ? CONAMA. Para os par?metros n?o relacionados nas normas citadas, estes, foram avaliados perante sua variabilidade no corpo d??gua. A grande maioria dos resultados obtidos apresentaram-se sem grandes varia??es mantendo as caracter?sticas naturais do estu?rio, fato que levou o IQA de todos os pontos como de qualidade BOA. Em contrapartida, alguns teores de oxig?nio dissolvido, f?sforo total em ?gua e sedimento, e clorofila obtidos, indicaram uma tend?ncia ? contamina??o por mat?ria org?nica. No entanto, esses contaminantes s?o oriundos de outras atividades nas comunidades circunvizinhas. Janeiro e abril, de maiores temperaturas, em geral, apresentaram menores valores de oxig?nio dissolvido. Em rela??o aos metais na ?gua, praticamente todos estavam abaixo do limite de detec??o do ICP-OES utilizado, ou, abaixo dos limites exigidos pelo CONAMA, indicando que estes metais tendem a ser carreados pela din?mica das mar?s ou precipitados no sedimento, caracterizando-se como IT igual a 1, isto ?, contamina??o ausente. Em rela??o aos metais no sedimento obteve-se tamb?m aus?ncia de toxicidade. Os descartes de salmoura, a priori, influenciam no comportamento da salinidade, no entanto, n?o alteram as caracter?sticas naturais do rio, mantendo um intervalo fixo de salinidade no decorrer dos anos. Em mar? baixa e nos per?odos de escassez de chuvas, foi poss?vel verificar uma tend?ncia a uma maior concentra??o dos sais e de nutrientes. A localiza??o caracter?stica de cada ponto de coleta tamb?m influenciou nos resultados. Os valores obtidos de c?lcio, magn?sio e o pH b?sico s?o caracter?sticos do corpo d??gua estudado e n?o sofreram grandes varia??es.
The Rio Grande do Norte is the largest producer of salt, sodium chloride, the country and holder of 97% of all salt produced. In this context, Salina Diamante Branco - SDB in Galinhos, dismisses the whole process of brine in the study area, the river Thomas-Galinhos. Thus, it is essential to assess the possible impacts of this Salineira activity in the body of water adjacent. Thus, there was a physical-chemical monitoring of water quality and sediment to obtain an environmental assessment, including indicators of pollution, the Water Quality Index - IQW and Toxicidez Index. Most samples were collected from July 2014 to April 2016, three months, for a total of 32 collections for high and low tide. In these collections, there were two other heavy metals in water and sediment. All results were related to the standards required by resolutions 357 of 17 March 2005 and 344 of 25 March 2004, both the National Environmental Council - CONAMA. For non listed in the cited standards parameters, these were evaluated before its variability in the water body. The vast majority of results presented without great variations while maintaining the natural characteristics of the estuary, a fact that led the IQW all points as quality GOOD. In contrast, some levels of oxygen dissolved total phosphorus in water and sediment, and obtained chlorophyll, indicated a tendency to contamination by organic matter. However, these contaminants are from other activities in the surrounding communities. January and April, higher temperatures generally showed lower values of dissolved oxygen. Regarding metals in water, almost all were below the ICP-OES detection limit or below the limits required by CONAMA, indicating that these metals tend to be adduced by the dynamics of tidal or precipitated sediment, characterizing as IT = 1, absent contamination. Regarding metals in sediment was obtained also no toxicity. Brine disposal a priori influence the behavior of the salinity, however, do not alter the natural characteristics of the river, keeping a fixed range of salinity over the years. At low tide and periods of drought, we found a trend to a higher concentration of salts and nutrients. The location characteristic of each collection point also influenced the results. The values of calcium, magnesium and alkaline pH are characteristic of the body of water and studied underwent no significant changes.
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Schülke, Yvonne [Verfasser], and Lorenz [Akademischer Betreuer] Dittmann. "Farbe und Ton. Ein Beitrag zur Farb- und Tongestaltung des deutschen Klassizimus am Beispiel von Johann Heinrich Schmidt gen. Fornaro (1757-1821). Mit einem Werkverzeichnis / Yvonne Schülke ; Betreuer: Lorenz Dittmann." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1177032651/34.
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Richards, David John. "'Each challenge to the skin' : the significance of the body in the poetry of Thom Gunn." Thesis, King's College London (University of London), 2004. https://kclpure.kcl.ac.uk/portal/en/theses/each-challenge-to-the-skin--the-significance-of-the-body-in-the-poetry-of-thom-gunn(4e93c97c-765c-44d2-80ba-60aa7605330b).html.
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Bramhall, Michael. "Development of biomarkers to predict disease outcome in gut inflammation." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/development-of-biomarkers-to-predict-disease-outcome-in-gut-inflammation(7a4219ef-2091-40bd-a6cf-754c803bcaa1).html.
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Reusability and reliability of published data are fundamental requirements for translating results from animal experiments into reliable clinical biomarkers. Current success rates for biomarker discovery are poor, and we need to develop new tools to collate, integrate and analyse datasets, such as knowledge bases, that would enable more effective translation from mouse to human or across disciplines. However, concerns about the validity, reproducibility and replicability of existing data must be addressed first. Here, I interrogate the quality of methods reporting in experimental models of infection and inflammation. Despite evidence that most of the assessed parameters, such as sex and age, can influence the experimental results, the quality of methods reporting was poor. Inadequate methods reporting means that it is not always possible to confirm whether findings were due to improper experimental conditions that biased the results. Thus, such inaccuracies would have an impact on the construction of knowledge base tools that require appropriate annotation. However, I provide reusable checklists that could improve the quality of methods reporting prior to publication and can be used to verify papers post-publication to enable researchers from different fields to interrogate published data. Another reason that biomarkers may fail is that it can be difficult to determine the causative pathways that will better predict disease outcome in a chronically inflamed tissue where multiple pathways are happening simultaneously. I conducted novel research to identify and verify whether investigating animal models long before onset of colitis would identify potentially causative biomarkers for colitis in an animal model. Previous studies have shown early influx of dendritic cells are associated with resistance to Trichuris muris-induced colitis in mice, suggesting early biomarkers may be detectable that might predict disease outcome in inflammatory diseases, such as inflammatory bowel disease (IBD).In the T. muris colitis model, I identified differences in gene expression of multiple components of the receptor for advanced glycation end-products (RAGE) activation pathway between colitis-resistant and colitis-susceptible mice, occurring just 24 hours post infection; before any observable clinical symptoms were present. RAGE is a receptor that binds products of damage, such as calprotectin, and initiates pro-inflammatory cascades. However, RAGE can be cleaved from the cell membrane to form a soluble receptor (sRAGE) that cannot mediate proinflammatory signals, yet can bind to damage products, effectively rendering them harmless. During a longer infection timecourse, colitis-resistant mice produced significantly more sRAGE during infection, consistent with an increased ability to prevent inflammatory ligands from activating membrane-bound RAGE. These findings were also supported by additional experiments using T. muris infection in Il-10-/- mice. In summary, I have carried out an analysis of methods reporting quality in immunology research that can help improve the reliability of existing data relevant to the further study of IBD and beyond. I have also identified sRAGE as a potential biomarker for the onset of colitis in the T. muris infection model, with implications for diagnosis and treatment of IBD in a clinical setting.
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Wei, Wen. "Apprentissage automatique des altérations cérébrales causées par la sclérose en plaques en neuro-imagerie multimodale." Thesis, Université Côte d'Azur, 2020. http://www.theses.fr/2020COAZ4021.
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La sclérose en plaques (SEP) est la maladie neurologique évolutive la plus courante chez les jeunes adultes dans le monde et représente donc un problème de santé publique majeur avec environ 90 000 patients en France et plus de 500 000 personnes atteintes de SEP en Europe. Afin d'optimiser les traitements, il est essentiel de pouvoir mesurer et suivre les altérations cérébrales chez les patients atteints de SEP. En fait, la SEP est une maladie aux multiples facettes qui implique différents types d'altérations, telles que les dommages et la réparation de la myéline. Selon cette observation, la neuroimagerie multimodale est nécessaire pour caractériser pleinement la maladie. L'imagerie par résonance magnétique (IRM) est devenue un biomarqueur d'imagerie fondamental pour la sclérose en plaques en raison de sa haute sensibilité à révéler des anomalies tissulaires macroscopiques chez les patients atteints de SEP. L'IRM conventionnelle fournit un moyen direct de détecter les lésions de SEP et leurs changements, et joue un rôle dominant dans les critères diagnostiques de la SEP. De plus, l'imagerie par tomographie par émission de positons (TEP), une autre modalité d'imagerie, peut fournir des informations fonctionnelles et détecter les changements tissulaires cibles au niveau cellulaire et moléculaire en utilisant divers radiotraceurs. Par exemple, en utilisant le radiotraceur [11C]PIB, la TEP permet une mesure pathologique directe de l'altération de la myéline. Cependant, en milieu clinique, toutes les modalités ne sont pas disponibles pour diverses raisons. Dans cette thèse, nous nous concentrons donc sur l'apprentissage et la prédiction des altérations cérébrales dérivées des modalités manquantes dans la SEP à partir de données de neuroimagerie multimodaleMultiple Sclerosis (MS) is the most common progressive neurological disease of young adults worldwide and thus represents a major public health issue with about 90,000 patients in France and more than 500,000 people affected with MS in Europe. In order to optimize treatments, it is essential to be able to measure and track brain alterations in MS patients. In fact, MS is a multi-faceted disease which involves different types of alterations, such as myelin damage and repair. Under this observation, multimodal neuroimaging are needed to fully characterize the disease. Magnetic resonance imaging (MRI) has emerged as a fundamental imaging biomarker for multiple sclerosis because of its high sensitivity to reveal macroscopic tissue abnormalities in patients with MS. Conventional MR scanning provides a direct way to detect MS lesions and their changes, and plays a dominant role in the diagnostic criteria of MS. Moreover, positron emission tomography (PET) imaging, an alternative imaging modality, can provide functional information and detect target tissue changes at the cellular and molecular level by using various radiotracers. For example, by using the radiotracer [11C]PIB, PET allows a direct pathological measure of myelin alteration. However, in clinical settings, not all the modalities are available because of various reasons. In this thesis, we therefore focus on learning and predicting missing-modality-derived brain alterations in MS from multimodal neuroimaging data
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Lampard, Pete. "Understanding culture in social movements : a historical materialist approach to the Guy Fawkes mask." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/understanding-culture-in-social-movements-a-historical-materialist-approach-to-the-guy-fawkes-mask(e8f4232c-a0aa-4970-b335-1fd651d01eb0).html.
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Social movement scholarship has been slower to incorporate cultural theory than other domains since the 'cultural turn' within social science and the humanities. The leading perspectives in this regard, within studies of social movements, have been frame alignment and those looking to understand 'new social movements'. While these bring culture into focus through a wealth of literature since the 1970s and 1980s, this thesis argues that they remain inadequate in understanding the full role of culture. While the former rely too heavily on static, overly instrumental, powerless and voluntarist notions of culture, due in part to their early affiliation with the resource mobilization paradigm, the latter create an altogether too ideational notion of culture, overlooking the importance of material distribution and one's social position in the production and reproduction of culture. It is the contention of the author that social movement scholarship requires a more comprehensive and holistic approach to culture. This thesis therefore offers an original contribution in arguing for a historical materialist approach to social movements and culture that foregrounds the ideas of Antonio Gramsci and Raymond Williams. This perspective, by contrast, provides an approach to culture that is dynamic, historical, and appreciative of the role of power. In order to show the added value and utility of a historical materialist approach to culture, this thesis provides a detailed and concrete application of the theory to a specific social movement and its use of popular cultural artefact that has received growing attention in recent years for its apparent worldwide diffusion: the Guy Fawkes mask. Through a protest event analysis this research first of all establishes the extent of this diffusion and thus the mask's significance across diverse protest groups. In order to explore the practice of adopting the mask in more detail, this research uses one of the main contexts in which the mask has been employed for further analysis: the Occupy Movement (specifically Occupy London). Through interviews with participants of Occupy London, this research makes the argument that popular cultural forms are made available for use over time through previous human activity, and therefore that their use is both enabled and constrained by wider social and material factors. It also argues that the mask's availability as a practice is subject to cultural contestation and its capacity, due to these wider contextual factors, to resonate with different groups. The argument in this thesis is that existing approaches (such as framing and new social movement theories) fail to bring about such necessary discussions around culture, and that through a historical materialist framework it is possible to more sufficiently analyse the power-laden, conditioned, and ever-changing basis from which such practices emerge and diffuse.
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Jackson, Matthew Albert. "Novel approaches to analysing 16S ribosomal RNA gene sequencing profiles of the gut microbiota in human health research." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/novel-approaches-to-analysing-16s-ribosomal-rna-gene-sequencing-profiles-of-the-gut-microbiota-in-human-health-research(87401bf4-e566-429f-94f7-40cf9d8a3fef).html.
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There is an increasing body of research associating the gut microbiome with human health. This has been fuelled by the development of untargeted techniques to profile whole microbial communities. A common approach is to sequence the 16S rRNA gene as a marker for taxonomic quantification. However, the results of such analyses are of limited use. The high-dimensional sequencing data are typically reduced to operational taxonomic units (OTUs), which are purely analytical units with no direct biological interpretation. Furthermore, experimental and analytical variation can lead to poor reproducibility of results between such studies. Here, I present novel methods to address these limitations and improve the application of 16S rRNA gene sequencing to profiling of the gut microbiota in human health research. I first explore existing and simpler approaches to the analysis of 16S rRNA gene sequencing data by investigating gut microbiota associations with two phenotypes, host frailty and proton pump inhibitor use, identifying several novel associations with both. I then tackle the limited biological representation of OTUs by presenting a comprehensive comparison of OTU clustering algorithms, using heritability as a novel and biologically motivated quality measure. The results of this comparison provide guidance for the approaches used in later analyses. Finally, I present two novel, more complex, methods to summarise 16S rRNA gene sequencing data in human health studies; both of which address the high dimensionality and limited reproducibility and biological relevance of these datasets. Firstly, I identify gut microbiota associations with multiple diseases within a single study. This generates comparable results that enable the identification of key marker taxa consistently associated with health or disease. From this, I generate an index that can represent widescale gut microbiota composition within a single score that is also associated with host health. Secondly, I present a method to identify communities of interacting microbes within the gut microbiota and demonstrate that these reliably associate with host phenotypes across geographically diverse populations. In summary, this thesis addresses several issues currently associated with the analysis of 16S rRNA gene sequencing-based gut microbiota profiles and in turn identifies several novel biological phenomena. The techniques described herein should improve the utility of microbiota profiles derived from 16S rRNA gene sequencing and advance the field of gut microbiome research in human health.
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Broecker, Sebastian. "Aufbau und Anwendung einer Methode zur Identifizierung und Quantifizierung von Giften und deren Metaboliten in Blut und Haaren in der Systematischen Toxikologischen Analyse mittels Flüssigchromatographie-Quadrupol-Flugzeitmassenspektrometrie-Kopplung (LC-QTOF-MS)." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16461.
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Die Systematische Toxikologische Analyse (STA) stellt auf Grund der großen Vielfalt und der ständigen Zunahme an toxikologisch relevanten Substanzen eine der größten Herausforderungen in der chemischen Analyse dar. In der vorliegenden Arbeit wurde daher die Eignung der Flüssigchromatographie in Kombination mit der Hybrid-Quadrupol-Flugzeitmassenspektrometrie (LC-QTOF-MS) für diesen Zweck untersucht. Dazu wurden eine Datenbank mit über 7360 und eine CID-Spektrenbibliothek mit mehr als 2720 toxikologisch relevanten Substanzen erstellt und geeignete Probenvorbereitungsmethoden entwickelt. Die Erprobung der Methoden erfolgte an dotierten Blut- und Haarproben. Hierbei zeigte sich, dass die Analyse im Auto-MS/MS-Modus (Messzyklen von MS- und MS/MS-Spektren) eine Identifizierung basischer Substanzen mittels CID-Spektren zwischen 0,5 und 2 ng/ml im Blut ermöglichte. Die Nachweisgrenzen der für 24 Wirkstoffe validierten Methode in Haaren lagen bei 3 bis 15 pg/mg. Die Eignung der LC-QTOF-MS zur STA von Haarproben wurde an 30 Drogentodesfällen und 60 Todesfällen mit bekannter chronischer Medikamenteneinnahme zu Lebzeiten sowie an 77 Blutproben nachgewiesen. Für die Suche nach Metaboliten wurde ein Metaboliten-Tool entwickelt. In der praktischen Anwendung auf Datenfiles von Blut- und Haarproben erwies sich das Tool als wertvolles Hilfsmittel zur Identifizierung unbekannter Peaks und zur Bestätigung von Suchergebnissen in der Datenbank. Zur automatischen Konzentrationsabschätzung identifizierter Substanzen wurde ein Tool „Estimate Concentration“ geschaffen. Die Überprüfung des Verfahrens an realen Blut- und Haarproben durch Vergleich mit HPLC-DAD- und GC-MS-Ergebnissen wies eine gute Übereinstimmung der Konzentrationen auf. Insgesamt zeigten die Untersuchungen, dass die LC-QTOF-MS zurzeit die am besten geeignete Methode für die STA darstellt. Auch bei einem erst später aufkommenden Verdacht kann eine gezielte Suche in dem bereits gemessenen Datenfile durchgeführt werden.Due to the large variety and the steady increase of toxicologically relevant substances, systematic toxicological analysis (STA) is one of the most difficult tasks in analytical chemistry and, therefore, a steady topic of research and methodical improvement. For this reason, the suitability of liquid chromatography in combination with hybrid quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) for STA was investigated. For this purpose, a database of more than 7360 and a CID spectra library of more than 2720 toxicologically relevant substances and suitable methods for sample preparation were developed. The application was evaluated at spiked blood and hair samples. It was found that the analysis in Auto-MS/MS mode (alternating measurement cycles of MS and MS/MS spectra) allowed substance identification in blood using CID spectra between 0.5 and 2 ng/ml for basic substances. The detection limits of the validated method in hair ranged from 3 to 15 pg/mg for 24 drugs. The suitability of LC-QTOF-MS for STA was tested for hair samples from 30 drug-related death cases and from 60 death cases with known chronic medication as well as for 77 blood samples. For the search of metabolites, a metabolite tool was developed. In the practical application to data files from blood and hair samples, the tool proved to be very helpful for identification of unknown peaks and for confirmation of results obtained only from the database without CID spectra. A tool "Estimate Concentration" was created for automatic estimation of concentrations of identified substances. The application to real blood and hair samples and the comparison of the concentrations with results from HPLC-DAD and GC-MS showed good agreement. Overall, these investigations showed that LC-QTOF-MS is currently the most favorable method for STA. Because of the comprehensive registration of all substances in a sample, the data files can be checked for the presence of certain poisons even later without new measurements.
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Jileček, Jan. "Analýza a klasifikace dat ze snímače mozkové aktivity." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2019. http://www.nusl.cz/ntk/nusl-403817.
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This thesis aims to implement methods for recording EEG data obtained with the neural activity sensor OpenBCI Ultracortex IV headset. It also describes neurofeedback, methods of obtaining data from the motor cortex for further analysis and takes a look at the machine learning algorithms best suited for the presented problem. Multiple training and testing datasets are created, as well as a tool for recording the brain activity of a headset-wearing test subject, which is being visually presented with cognitive challenges on the screen in front of him. A neurofeedback demo app has been developed, presented and later used for calibration of new test subjects. Next part is data analysis, which aims to discriminate the left and right hand movement intention signatures in the brain motor cortex. Multiple classification methods are used and their utility reviewed.
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Vendrell, Arasa Alexandre. "SCF cdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7153.
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L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida per la mutació del complexe SCFCDC4. La inhibició de la mort causada per l'activació sostinguda de Hog1 depèn de la via d'extensió de la vida. Quan Hog1 s'activa de manera sostinguda, la mutació al complexe SCFCDC4 fa que augmenti l'expressió gènica depenent de Msn2 i Msn4 que condueix a una sobreexpressió del gen PNC1 i a una hiperactivació de la deacetilassa Sir2. La hiperactivació de Sir2 és capaç d'inhibir la mort causada per l'activació sostinguda de Hog1.També hem observat que la mort cel·lular causada per l'activació sostinguda de Hog1 és deguda a una inducció d'apoptosi. L'apoptosi induïda per Hog1 és inhibida per la mutació al complexe SCFCDC4. Per tant, la via d'extensió de la vida és capaç de prevenir l'apoptosi a través d'un mecanisme desconegut.
Sustained Hog1 activation leads to an inhibition of cell growth. In this work, we have observed that the lethal phenotype caused by sustained Hog1 activation is prevented by SCFCDC4 mutants. The prevention of Hog1-induced cell death by SCFCDC4 mutation depends on the lifespan extension pathway. Upon sustained Hog1 activation, SCFCDC4 mutation increases Msn2 and Msn4 dependent gene expression that leads to a PNC1 overexpression and a Sir2 deacetylase hyperactivation. Then, hyperactivation of Sir2 is able to prevent cell death caused by sustained Hog1 activation.
We have also observed that cell death upon sustained Hog1 activation is due to an induction of apoptosis. The apoptosis induced by Hog1 is decreased by SCFCDC4 mutation. Therefore, lifespan extension pathway is able to prevent apoptosis by an unknown mechanism.
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Peng, Yu-Che, and 彭宥喆. "Optoelectronic performance of GaN-based LEDs grown on flat-top pyramid patterned sapphire substrates." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/65235468868755520482.
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碩士國立中興大學
精密工程學系所
103
In this study, theflat-top pyramid patterned sapphire substrates(FTP-PSSs) have been fabricated for the growth of GaN-based epilayers. Moreover, the blue light emitting diodes with an emission wavelength of approximately 470 nm were also prepared on these FTP-PSSs. Three various FTP-PSSs, that were denoted as FTP-PSS A, FTP-PSS B, and FTP-PSS C, respectively, were formed via the light lithography and wet etching processes. The diameters of circle areas on the top regions of FTP-PSS A, FTP-PSS B, and FTP-PSS C were 0.95, 1.99, and 3.06 m, while the distances between patterns of these three FTP-PSSs were 0.85, 0.85, and 0.75 m, respectively. In addition, the heights of patterns of these three FTP-PSSs were all fixed at 1.3 m. Except for the FTP-PSSs, the GaN epilayer and the LED device were also prepared on the conventional sapphire substrate (CSS) as the contrasted samples. For the epitaxial growth on CSS, the etch-pit-density (EPD) of u-GaN was determined to be 1.25×107cm-2. When the u-GaN epilayers were deposited on FTP-PSS A, FTP-PSS B, and FTP-PSS C, their EPDs were reduced to 1.39×106, 2.31×106, and 7.17×106cm-2, respectively. Based on the X-ray diffraction results, the full width at half maximum (FWHM) values of rocking curves at GaN(002) for the u-GaN epilayers grown on CSS, FTP-PSS A, FTP-PSS B, and FTP-PSS C were measured to be 412, 238, 346, and 357 arcsec, respectively. Meanwhile, the FWHM values at GaN(102) for these four samples were 593, 327, 352, and 372 arcsec, respectively. Obviously, the epilayer quality can be improved efficiently through the growth on these FTP-PSSs, especially for the FTP-PSS A. The photoluminescence measurements were performed on the LED epitaxial structures grown on CSS, FTP-PSS A, FTP-PSS B, and FTP-PSS C to evaluate the internal quantum efficiency (IQE) characteristics. The IQE values of these four samples were analyzed to be 65.12%, 78.68%, 76.54%, and 72.89%, respectively. After fabricating the LEDs on CSS and FTP-PSSs, it can be found the forward voltages (@350 mA) were all measured to be 3.2-3.3 V. Moreover, the output powers (@350 mA) of LEDs prepared on CSS, FTP-PSS A, FTP-PSS B, and FTP-PSS C were 157.38, 253.94, 240.86, and 232.60 mW, respectively. In comparison to the LED on CSS, there were 61.35%, 53.04%, and 47.79% enhancements in the output power (@350 mA) for the devices on FTP-PSS A, FTP-PSS B, and FTP-PSS C, respectively. By using the SpecLED software, the trends of simulated results for light output and IQE characteristics of the LEDs on CSS and FTP-PSSs were similar to those of experimental results. On the other hand, the Ratro software was employed to simulate the light extraction efficiencies (LEEs) of these samples. According to the Ratro-simulated results, the LED prepared on FTP-PSS A possessed the highest LEE than that of the other samples. Because FTP-PSS A had a higher density of shape per unit area, which can improve the LEE of the device. Based on the above-mentioned results, the use of FTP-PSS can both enhance the epilayer quality and increase the light extraction of LED. In particular for the LED fabricated on FTP-PSS A, it reveals this device has better optoelectronic performances.
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"Science Fiction is Good for You Too: A Reply to Martha Nussbaum's Theory of Literary Engagement." Thesis, 2015. http://hdl.handle.net/10388/ETD-2015-03-2012.
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In this study I examine the arguments made by Martha Nussbaum in Poetic Justice in defence of a positive role for literary engagement in the process of moral and political judgement formation. Nussbaum argues that novel reading offers a unique chance to engage our empathy in morally beneficial ways, because it stands as a kind of practice run for appropriate moral judgement through the adoption of an emotionally engaged yet critically distant “Judicious Spectator” stance when reading. I examine her account of the activity and purported benefits of reading and argue that her use of the Judicious Spectator concept is incompatible with her claims about the structure of novels and the experience of reading. I suggest examining an alternative set of fictions, namely the genre of science fiction and in particular Ursula K. Le Guin’s novel The Left Hand of Darkness as a means to assess whether Nussbaum’s account plausibly captures the moral value of reading fiction. I argue that even a charitable reading of Nussbaum’s Judicious Spectator concept cannot explain the central thought experiment at the heart of Le Guin’s novel, as it invites readers to contemplate a re-evaluation of their own self-identities or foundational assumptions, allowing them to abandon beliefs and understandings that have perhaps unwittingly coloured their previous moral reasoning without undergoing the scrutiny of justificatory rigour. This resulting type of re-evaluation is, I argue, primarily self-reflective in nature and not externally directed to programmatic outcomes like the possible interpretations of the novel available to Nussbaum. This good, which I label ‘appropriate doubt’, is defended as a general feature of certain kinds of novel reading, and as worthy of moral attention. I conclude that this shows Nussbaum’s account of engagement with fiction to be at best, incomplete.
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Hsu, Wei-Chi, and 徐偉棋. "Fabrication and Characteristics of Tip-Free Core-Shell InGaN/GaN Nanorod Green Light Emitting Diodes." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/3k6ttx.
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碩士國立交通大學
光電工程研究所
102
In recent years, c-axis-oriented gallium nitride (GaN) based nanorods light-emitting diodes (LEDs) have attracted intensive attention. The reason why GaN nanorod LEDs is so popular can be attributed to the following advantages. First, the area of active regions will increase, while they were grown on three-dimensional (3D) structure nanorods template. Second, the defect density of MQWs grown on nanorods template can be decreased. Third, light extraction performance is greatly enhanced. Fourth, the growth of non-polar and semi-polar multiple quantum well can decrease the polarization-induced effect. In the epitaxial process of the GaN materials in LEDs, the growth rate of multi quantum wells and the indium (In) composition are various in different growth orientations, causing inhomogeneous thickness of the active regions and anisotropic indium distributions in multi quantum wells (MQWs). Furthermore, while re-growing III-nitride materials on the nanorods template, the gradually accumulated materials have a tendency to form pointed tips on the top of each nanorods. This implies a non-uniform electric field distribution will occur on the topmost of nanorod LED. As a result, EL emission wavelength will have a giant blue shift as the injected current increases. These characteristics may make the emission wavelength of nanorod LED deviated from the original design and limit its applications. To conquer the challenges, we propose a novel nanorod LED structure. In our newly designed nanorod LED, the top of nanorod is covered by a dielectric material nano-disk. During the nanorod LED growth, the passivation of dielectric nano-disk on the top can suppress the growth of polar and semi-polar MQWs, leading to a high proportion of non-polar active region. Therefore, the quantum confined stark effect in MQWs can be greatly reduced. Moreover, indium spatially distribution in MQWs may become uniform. On the other hand, with this dielectric material nano-disk, the electric field on the tip of nanorod LED is reduced substantially. Thus, the major of difficulty of the giant blue shift existing in the EL spectra can be avoided. In this work, we have successfully demonstrated that our tip-free core-shell nanorod LEDs indeed possess, the superior features as described above when compared with its conventional counterpart. It is believed that our study shown here will pave a key study for the advancement of high efficient LEDs with excellent performance.
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Kammermeier, Tom [Verfasser]. "Structural and magnetic investigation of dilute magnetic semiconductors based on GaN and ZnO / von Tom Kammermeier." 2010. http://d-nb.info/1001190459/34.
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Goller, Tobias. "Das murine Bptf/Fac1-Gen : Struktur, Expression und Funktion während der frühen Postimplantationsentwicklung /." 2007. http://www.gbv.de/dms/bs/toc/539716863.pdf.
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Heinrich, Oliver. "Das Argininosuccinat Lyase-Gen von Volvox carteri : Struktur und heterologe Expression in Chlamydomonas reinhardtii /." 2000. http://www.gbv.de/dms/bs/toc/321061195.pdf.
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Hou, Tsung-You, and 侯宗佑. "Marketing Strategy Analysis Using SWOT for The Country Wine Manufacturing Industry － A Case Study of Gin-Yu-Ton Company." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/75099779485355085488.
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碩士國立高雄大學
高階經營管理碩士在職專班(EMBA)
97
The country wine manufacturing industry has been long a governor-dominated business since it comes to the marketplace. With development constraints, the wine kinds also differ from seasons, weather, and geographical characteristics. Therefore, before opened to the private, it is almost a developing industry with great opportunities to work on. However, there are several issues that draw back its development, including that (1) the wine manufacturing industry in Taiwan is still at the infant stage, (2) the regulations for this industry are still unknown, and (3) there is no professionals to help its development. Accordingly, it is quite necessary to build up a marketing strategy and to carry out the wine innovation. The Gin-Yu-Ton is a newly private country wine manufacturing company that is facing the increasingly tense competition. In this thesis, a case study of Gin-Yu-Ton is conducted to derive its relevant marketing strategy. The case study uses SWOT analysis technique to disclose the Gin-Yu-Ton’s opportunity, threat, strength, and weakness as the marketing axis. Research suggestions are as follows: (1) should adopt a strategy of “meager profit but high turnover”, (2) should develop a brand marketing strategy for the concern of globalization, and (3) should incorporate with the leisure industry to enhance its marketing ability.