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Journal articles on the topic 'TopA'

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Published: 4 June 2021

Last updated: 7 February 2022

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1

Magri, Dirceu, and Joelma Santana Siqueira. "Francisco Topa - Entrevista." Jangada: crítica | literatura | artes, no. 12 (December 21, 2018): 178–84. http://dx.doi.org/10.35921/jangada.v1i12.213.

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Francisco Topa é Professor Associado do Departamento de Estudos Românicos da Faculdade de Letras da Universidade do Porto, lecionando nas áreas de Literatura e Cultura Brasileiras, Crítica Textual, Literaturas Africanas de Língua Portuguesa e Literaturas Orais e Marginais. Doutorou-se em Literatura, em 2000, na mesma Faculdade, com uma tese sobre o poeta barroco Gregório de Matos. Obteve em 2016, também na FLUP, o título de Agregado em Estudos Literários, Culturais e Interartísticos, especialidade de Literatura e Cultura. Sua investigação tem estado dirigida para a literatura portuguesa e brasileira dos séculos XVII e XVIII, para as literaturas africanas de língua portuguesa e para algumas áreas da literatura oral e marginal. Tem participado em congressos da especialidade, em Portugal e no estrangeiro, e é autor de vinte livros e de cerca de uma centena de artigos e outras publicações nos domínios mencionados.

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2

Williams, Neal K., and Judith P. Klinman. "Whence topa? Models for the biogenesis of topa quinone in copper amine oxidases." Journal of Molecular Catalysis B: Enzymatic 8, no. 1-3 (2000): 95–101. http://dx.doi.org/10.1016/s1381-1177(99)00071-5.

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3

Kano, Kenji, Toshio Mori, Bunji Ono, Masashi Goto, and Tokuji Ikeda. "Characterization of topa quinone cofactor." Biochimica et Biophysica Acta (BBA) - General Subjects 1157, no. 2 (1993): 324–31. http://dx.doi.org/10.1016/0304-4165(93)90117-q.

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4

Yan, Rong, Shikun Hu, Ning Ma, et al. "Regulatory Effect of DNA Topoisomerase I on T3SS Activity, Antibiotic Susceptibility and Quorum- Sensing-Independent Pyocyanin Synthesis in Pseudomonas aeruginosa." International Journal of Molecular Sciences 20, no. 5 (2019): 1116. http://dx.doi.org/10.3390/ijms20051116.

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Topoisomerases are required for alleviating supercoiling of DNA during transcription and replication. Recent evidence suggests that supercoiling of bacterial DNA can affect bacterial pathogenicity. To understand the potential regulatory role of a topoisomerase I (TopA) in Pseudomonas aeruginosa, we investigated a previously isolated topA mutation using genetic approaches. We here report the effects of the altered topoisomerase in P. aeruginosa on type III secretion system, antibiotic susceptibility, biofilm initiation, and pyocyanin production. We found that topA was essential in P. aeruginosa, but a transposon mutant lacking the 13 amino acid residues at the C-terminal of the TopA and a mutant, named topA-RM, in which topA was split into three fragments were viable. The reduced T3SS expression in topA-RM seemed to be directly related to TopA functionality, but not to DNA supercoiling. The drastically increased pyocyanin production in the mutant was a result of up-regulation of the pyocyanin related genes, and the regulation was mediated through the transcriptional regulator PrtN, which is known to regulate bacteriocin. The well-established regulatory pathway, quorum sensing, was unexpectedly not involved in the increased pyocyanin synthesis. Our results demonstrated the unique roles of TopA in T3SS activity, antibiotic susceptibility, initial biofilm formation, and secondary metabolite production, and revealed previously unknown regulatory pathways.

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5

Karović, Dragan. "Neke mogućnosti povećanja efikasnosti projektila avionskog topa." Vojnotehnicki glasnik 40, no. 5 (1992): 12–14. http://dx.doi.org/10.5937/vojtehg9201012k.

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6

Mure, Minae, and Katsuyuki Tanizawa. "Chemical and Biochemical Characteristics of Topa Quinone." Bioscience, Biotechnology, and Biochemistry 61, no. 3 (1997): 410–17. http://dx.doi.org/10.1271/bbb.61.410.

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7

Stewart, Natalee, Jingyang Feng, Xiaoping Liu, et al. "Loss of topoisomerase I function affects the RpoS-dependent and GAD systems of acid resistance in Escherichia coli." Microbiology 151, no. 8 (2005): 2783–91. http://dx.doi.org/10.1099/mic.0.28022-0.

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Acid resistance (AR) in Escherichia coli is important for its survival in the human gastrointestinal tract and involves three systems. The first AR system is dependent on the sigma factor RpoS. The second system (the GAD system) requires the glutamate decarboxylase isoforms encoded by the gadA and gadB genes. The third system (the ARG system) requires the arginine decarboxylase encoded by adiA. Loss of topoisomerase I function from topA deletion or Tn10 insertion mutations lowered the resistance to killing by pH 2 or 2·5 treatment by 10-fold to >100-fold. The RpoS and GAD systems were both affected by the topA mutation, but the ARG system of AR was not affected. Northern blot analysis showed that induction of gadA and gadB transcription in stationary phase and at pH 5·5 was decreased in the topA mutant. Western blot analysis showed that the topA mutation did not affect accumulation of RpoS, GadX or GadW proteins. Topoisomerase I might have a direct influence on the transcription of AR genes. This influence does not involve R-loop formation as the overexpression of RNase H did not alleviate the decrease of AR caused by the topA mutation. The effect of the topA mutation could be suppressed by an hns mutation, so topoisomerase I might be required to counteract the effect of H-NS protein on gene expression, in addition to its influence on RpoS-dependent transcription.

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8

Wilfong, Lalan S., John Russell Hoverman, Nate Gosse, Marcus A. Neubauer, and Vanessa Torres. "Changing physician compensation and implementing new technology to enhance pathways compliance." Journal of Clinical Oncology 34, no. 7_suppl (2016): 187. http://dx.doi.org/10.1200/jco.2016.34.7_suppl.187.

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187 Background: Pathways have shown to decrease cost of care while maintaining efficacy of treatment. In 2005, The US Oncology Network, which includes Texas Oncology, P.A. (TOPA) developed physician-led clinical pathways based on national guidelines, cost and efficacy. This abstract reviews the impact of changes TOPA initiated to improve pathway compliance Methods: Since 2011, TOPA has assessed pathways compliance using the iKnowMed (iKM) electronic medical record. Individual compliance was reported to each physician, but no incentives were tied to this. In 2015, the TOPA annual productivity bonus structure (2% of compensation) was changed to introduce pathways compliance and exception documentation thresholds, with penalties for sub-threshold performance. Additionally, TOPA sought to improve on iKM-based data collection and assessment. Previously, there were data challenges with pathways assessed retrospectively, offering limited visibility at the time of decision-making. In September 2015, new technology (Clear Value Plus – CVP) was embedded within iKM, which allowed prospective pathways assessment and provided real-time compliance reporting. Results: Introduction of individual incentives and improved decision support increased pathways compliance. For the initial yearly bonus measurement period, TOPA pathways compliance was 78%. After implementation of the new bonus structure, compliance increased significantly to 83% (p<0.0001). Implementation of CVP further improved pathway compliance for comparable reporting periods from 78% in September 2014 to 90% in September of 2015 (p<0.0001) Conclusions: We have shown that even a small change in compensation significantly influences physician pathways compliance. Additionally, technology to assist physicians with documentation and real-time assessment also significantly improves pathway compliance. [Table: see text] [Table: see text]

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9

Klinman, Judith P. "The multi-functional topa-quinone copper amine oxidases." Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1647, no. 1-2 (2003): 131–37. http://dx.doi.org/10.1016/s1570-9639(03)00077-3.

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10

Hammond, G. G., P. J. Cassidy, and K. M. Overbye. "Novobiocin-dependent topA deletion mutants of Escherichia coli." Journal of Bacteriology 173, no. 17 (1991): 5564–67. http://dx.doi.org/10.1128/jb.173.17.5564-5567.1991.

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11

Choi, Yoon-Ho, Ryuichi Matsuzaki, Toshio Fukui, et al. "Copper/Topa Quinone-containing Histamine Oxidase fromArthrobacter globiformis." Journal of Biological Chemistry 270, no. 9 (1995): 4712–20. http://dx.doi.org/10.1074/jbc.270.9.4712.

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12

Naranjo, Anastacio Perez, and Robert J. McNeil. "EVALUATION OF ORCHARD PERFORMANCE OF THE HASS AVOCADO ON THREE Phytophthora cinnamomi Rands RESISTANT AND ONE SUSCEPTIBLE ROOTSTOCK." HortScience 27, no. 6 (1992): 604c—604. http://dx.doi.org/10.21273/hortsci.27.6.604c.

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The experiment compared productivity and vegetative growth of the Hass avocado on three avocado root rot resistant rootstocks and one susceptible rootstock. Hass trees on Duke 7 reported the largest number of fruit per tree and on G 755c the smallest five years after planting. Trees on Topa Topa and Duke 7 reported the highest average production four years after planting. Trees on G 755c were significantly lower in the amount of leaf N. Trees on Toro Canyon and G 755c showed significantly lower amounts of Na. Trees on Duke 7 showed a significantly higher level of Mn. Trees on G 755c were significantly smaller two years after planting. Trees on Topa Topa and Duke 7 showed a significantly larger canopy diameter than those on G 755c four years after planting. Trees on G 755c showed the smallest mean shoot growth four years after planting. Trees on G 755c had significantly larger trunk circumferences three and four years after planting. No statistical differences were found among rootstocks as to freeze damage to the Hass scions.

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13

Robinson, P. W., M. V. Mickelbart, and M. L. Arpaia. "595 PB 173 `HASS' AVOCADO PHENOLOGY IN CALIFORNIA - PRELIMINARY RESULTS." HortScience 29, no. 5 (1994): 517c—517. http://dx.doi.org/10.21273/hortsci.29.5.517c.

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Measurements of flowering, yield, vegetative and root growth were begun in Spring 1992 to establish a phenological model for `Hass' avocado. Although rootstock (Thomas', Topa Topa', Duke 7' and `D9') did not affect the timing or intensity of bloom, differences in yield were observed. Flowering occurred in March - April in both years, although the intensity of bloom in 1993 was drastically reduced due to an extremely heavy 1992-93 crop. Vegetative flushes occurred in April (following bloom) and July in both years. In 1993, however, cumulative growth was ca. 10-fold greater. Rootstock did not affect the timing or intensity of vegetative growth in either year. In both years, vegetative growth preceded root growth. In 1992, there were no differences detected in the timing or intensity of root growth related to rootstock. In 1993, however, the `Topa Topa' rootstock produced more roots throughout the growing season. The timing and intensity of root growth during the spring flush were similar in both years. During Fall 1993, root growth rates, however, were consistently higher than those observed in 1992. Additionally, while root growth ceased in November 1992, roots have continued to grow through January 1994.

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14

Brochu, Julien, Émilie-Vlachos Breton, and Marc Drolet. "Supercoiling, R-Loops, Replication and the Functions of Bacterial Type 1A Topoisomerases." Genes 11, no. 3 (2020): 249. http://dx.doi.org/10.3390/genes11030249.

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Type 1A topoisomerases (topos) are the only topos that bind single-stranded DNA and the only ones found in all cells of the three domains of life. Two subfamilies, topo I and topo III, are present in bacteria. Topo I, found in all of them, relaxes negative supercoiling, while topo III acts as a decatenase in replication. However, recent results suggest that they can also act as back-up for each other. Because they are ubiquitous, type 1A enzymes are expected to be essential for cell viability. Single topA (topo I) and topB (topo III) null mutants of Escherichia coli are viable, but for topA only with compensatory mutations. Double topA topB null mutants were initially believed to be non-viable. However, in two independent studies, results of next generation sequencing (NGS) have recently shown that double topA topB null mutants of Bacillus subtilis and E. coli are viable when they carry parC parE gene amplifications. These genes encode the two subunits of topo IV, the main cellular decatenase. Here, we discuss the essential functions of bacterial type 1A topos in the context of this observation and new results showing their involvement in preventing unregulated replication from R-loops.

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15

Aswat, Hijrawatil, and Syamsurijal Syamsurijal. "PENGGUNAAN MODEL RECIPROCAL TEACHING UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA MATA PELAJARAN IPA KELAS V SD NEGERI I TOPA KOTA BAUBAU." Sang Pencerah: Jurnal Ilmiah Universitas Muhammadiyah Buton 4, no. 2 (2019): 12–20. http://dx.doi.org/10.35326/pencerah.v4i2.293.

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Penelitian ini bertujuan untuk mengetahui keefektifan pelaksanaan pembelajaran terbalik (Reciprocal Teaching) terhadap hasil belajar IPA siswa kelas V SD Negeri I Topa Kota Baubau. Jenis penelitian ini adalah Penelitian Tindakan Kelas yang terdiri dari dua siklus, masing-masing sikluas 3 kali pertemuan. Subjek dalam penelitian ini adalah siswa Kelas V SD Negeri I Topa Kota Baubau tahun ajaran 2018/2019 sebanyak 20 siswa. Instrumen yang digunakan terdiri dari lembar observasi guru dan siswa serta tes berupa essay untuk melihat hasil belajar IPA. Hasil penelitian menunjukkan bahwa: (i) Pelaksanaan pembelajaran dengan menggunakan model pembelajaran terbalik (Reciprocal Teaching) mengalami peningkatan di setiap pertemuan baik dari segi keterlaksanaan pembelajaran maupun aktivitas belajar siswa. (ii) Terdapat peningkatan hasil belajar IPA siswa dari siklus I ke siklus II dengan menggunakan model pembelajaran terbalik (Reciprocal Teaching) pada siswa Kelas V SD Negeri I Topa Kota Baubau.

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16

Martín Rubio, María del Carmen. "Buscando a un Inca: la cripta de Topa Amaro." Investigaciones Sociales 9, no. 15 (2014): 77–108. http://dx.doi.org/10.15381/is.v9i15.6989.

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Las luchas fraticidas desatadas en el Tahuantinsuyo y la conmoción sufrida por sus gentes, ante la llegada de hombres y animales desconocidos, precipitaron el derrumbe de aquel Estado aparentemente sin resistencia. Pero una vez superada la sorpresa, los incas pusieron cerco al Cusco y, tras no poder tomar la ciudad, se refugiaron en las montañas de Vilcabamba, desde donde, tratando de expulsar a los extranjeros, iniciaron una incómoda guerra de guerrillas, durante casi cuarenta años, que sucesivamente dirigieron cuatro príncipes cusqueños descendientes del poderoso Huayna Cápac. En este artículo, mediante el estudio de nueva documentación, se aborda la figura y la muerte de Topa Amaro, el último gobernante vilcabambino; se analiza la evolución arquitectónica del Qorikancha, el templo en que recibieron sepultura los restos mortales del Inca, y se exponen los trabajos realizados para encontrar su cripta mortuoria

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17

Ruggiero, Christy E., Jennifer A. Smith, Katsuyuki Tanizawa, and David M. Dooley. "Mechanistic Studies of Topa Quinone Biogenesis in Phenylethylamine Oxidase†." Biochemistry 36, no. 8 (1997): 1953–59. http://dx.doi.org/10.1021/bi9628836.

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18

Burzio, Luis A., and J. Herbert Waite. "The Other Topa: Formation of 3,4,5-Trihydroxyphenylalanine in Peptides." Analytical Biochemistry 306, no. 1 (2002): 108–14. http://dx.doi.org/10.1006/abio.2002.5690.

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19

Bizard, Anna H., Xi Yang, Hélène Débat, et al. "TopA, the Sulfolobus solfataricus topoisomerase III, is a decatenase." Nucleic Acids Research 46, no. 2 (2017): 861–72. http://dx.doi.org/10.1093/nar/gkx1247.

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20

Nakamura, Nobuhumi, Ryuichi Matsuzaki, Yoon-Ho Choi, Katsuyuki Tanizawa, and Joann Sanders-Loehr. "Biosynthesis of Topa Quinone Cofactor in Bacterial Amine Oxidases." Journal of Biological Chemistry 271, no. 9 (1996): 4718–24. http://dx.doi.org/10.1074/jbc.271.9.4718.

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21

Dodić, Nenad, and Momčilo Milinović. "New concept of antiaircraft gun fire control." Vojnotehnicki glasnik 47, no. 6 (1999): 5–14. http://dx.doi.org/10.5937/vojtehg9906005d.

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22

Yigit, Hesna, and William S. Reznikoff. "Escherichia coli DNA Topoisomerase I and Suppression of Killing by Tn5 Transposase Overproduction: Topoisomerase I Modulates Tn5 Transposition." Journal of Bacteriology 180, no. 22 (1998): 5866–74. http://dx.doi.org/10.1128/jb.180.22.5866-5874.1998.

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ABSTRACT Tn5 transposase (Tnp) overproduction is lethal toEscherichia coli. The overproduction causes cell filamentation and abnormal chromosome segregation. Here we present three lines of evidence strongly suggesting that Tnp overproduction killing is due to titration of topoisomerase I. First, a suppressor mutation of transposase overproduction killing, stkD10, is localized in topA (the gene for topoisomerase I). ThestkD10 mutant has the following characteristics: first, it has an increased abundance of topoisomerase I protein, the topoisomerase I is defective for the DNA relaxation activity, and DNA gyrase activity is reduced; second, the suppressor phenotype of a second mutation localized in rpoH, stkA14 (H. Yigit and W. S. Reznikoff, J. Bacteriol. 179:1704–1713, 1997), can be explained by an increase in topA expression; and third, overexpression of wild-type topA partially suppresses the killing. Finally, topoisomerase I was found to enhance Tn5 transposition up to 30-fold in vivo.

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23

Topal, Julien. "Het ‘praktisch’ geweten: over de nood tot en voorwaarden voor morele intervisie." Algemeen Nederlands Tijdschrift voor Wijsbegeerte 109, no. 3 (2017): 347–64. http://dx.doi.org/10.5117/antw2017.3.topa.

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24

Thomas-Tate, Shurita, Julie Washington, and Jan Edwards. "Standardized Assessment of Phonological Awareness Skills in Low-Income African American First Graders." American Journal of Speech-Language Pathology 13, no. 2 (2004): 182–90. http://dx.doi.org/10.1044/1058-0360(2004/018).

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Accurate identification of students with poor phonological awareness skills is important to providing appropriate reading instruction. This is particularly true for segments of the population, such as African American students, who have a history of reading failure. The purpose of this study was to examine the performance of a group of African American first-grade students from low-income families on a standardized test of phonological awareness. Fifty-six African American first graders were given the Test of Phonological Awareness (TOPA; J. K. Torgesen & B. R. Bryant, 1994). Mean student performance on the TOPA was significantly below expected norms and negatively skewed. However, students' mean performance on a test of basic reading skills indicated performance within normal limits. Outcomes are discussed relative to the validity and predictive power of standardized phonological assessment instruments, in this case, the TOPA, for use with African American students and the possible influence of dialect on performance.

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25

Phillips, D., G. Weste, and J. M. Hinch. "Resistance to Phytophthora cinnamomi in callus tissue derived from three avocado cultivars." Canadian Journal of Botany 69, no. 9 (1991): 2026–32. http://dx.doi.org/10.1139/b91-255.

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Calli induced from various plant parts of avocado cultivars Topa Topa (susceptible), Duke 7 (moderately resistant), and Martin Grande (resistant) were inoculated with the root and collar rotting pathogen Phytophthora cinnamomi and examined for expression of resistance. Resistance was assessed quantitatively by measuring the rate of hyphal extension across the callus surface from the point of inoculation. Resistance in the callus tissue was associated with sparse, limited mycelial growth, in contrast to prolific, dense growth on and within susceptible callus. Rates of hyphal extension on calli of the resistant ‘Duke 7’ and ‘Martin Grande’ ranged from 1–3 mm day−1 compared with 4–7 mm day−1 on calli of ‘Topa Topa’. This difference in growth was significant (P = 0.05). This is the first report of avocado callus exhibiting resistance to P. cinnamomi and it mirrors that recorded for the whole plant for the three avocado cultivars tested. Thus, the level of resistance expressed by each cultivar appears to be innate whether the host tissue remains in an organized state or is in the form of an undifferentiated callus mass. The basis of the resistance expressed appeared to be largely physiological and (or) biochemical rather than anatomical. Assessing rates of hyphal colonization on undifferentiated callus masses in vitro may provide a new and useful assay for screening and selecting host lines in avocado resistant to P. cinnamomi. Key words: callus, avocado, in vitro, resistance, Phytophthora cinnamomi, Persea.

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26

Bhriain, Niamh Ni, and Charles J. Dorman. "Isolation and characterization of a topA mutant of Shigella flexneri." Molecular Microbiology 7, no. 3 (1993): 351–58. http://dx.doi.org/10.1111/j.1365-2958.1993.tb01127.x.

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27

Mure, Minae, Stephen A. Mills, and Judith P. Klinman. "Catalytic Mechanism of the Topa Quinone Containing Copper Amine Oxidases†." Biochemistry 41, no. 30 (2002): 9269–78. http://dx.doi.org/10.1021/bi020246b.

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28

TANIZAWA, Katsuyuki. "Molecular Mechanism of Topa Quinone Biogenesis in Copper Amine Oxidase." Kagaku To Seibutsu 35, no. 8 (1997): 569–75. http://dx.doi.org/10.1271/kagakutoseibutsu1962.35.569.

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29

Irsan, Irsan. "Peningkatan Kualitas Pembelajaran Matematika Melalui Penerapan Metode Tutor Sebaya Pada Murid Kelas Iv Sdn Topa Baubau." JKPD (Jurnal Kajian Pendidikan Dasar) 3, no. 2 (2018): 558. http://dx.doi.org/10.26618/jkpd.v3i2.1421.

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Improving the Quality of Mathematics Learning through the Application of Peer Tutor Method on Student IV of SDN Topa Baubau. Irsan. Primary teacher education. Faculty of Teacher Training and Education. University of Muhammadiyah Buton.This research is a classroom action research that aims to improve the quality of Mathematics learning through the application of Peer Tutor method to fourth grade students of SDN Topa Baubau in the even semester of academic year 2017/2018 with a total of 30 students. This research was conducted in two cycles. Each cycle has several stages: planning, execution, observation / observation, and reflection. Each cycle is held in 4 meetings. Data retrieval is done by using learning result test and observation. The collected learning result data was analyzed by using quantitative analysis and observation data was analyzed qualitatively. The results showed that the average score of students in the first cycle was 60.66, while in cycle II obtained an average score of 78. KKM standard used in schools is 65, it indicates that has been achieved student learning outcomes in class. From the results of this study can be concluded that by applying the Tutor Sebaya method of learning quality of Mathematics in fourth grade students of SDN Topa Baubau can increase. Keywords: Peer Tutor Method. Quality of Mathematics Learning. Peningkatan Kualitas Pembelajaran Matematika melalui Penerapan Metode Tutor Sebaya pada Murid Kelas IV SDN Topa Baubau. Irsan. Pendidikan Guru Sekolah Dasar. Fakultas Keguruan dan Ilmu Pendidikan. Universitas Muhammadiyah Buton. Penelitian ini adalah penelitian tindakan kelas (classroom action research) yang bertujuan untuk meningkatkan kualitas pembelajaran Matematika melalui penerapan metode Tutor Sebaya pada murid kelas IV SDN Topa Baubau semester genap tahun ajaran 2017/2018 dengan jumlah murid 30 orang. Penelitian ini dilaksanakan sebanyak dua siklus. Tiap siklus memiliki beberapa tahapan yaitu perencanaaan, pelaksanaan, pengamatan/observasi, dan refleksi. Masing-masing di siklus dilaksanakan 4 kali pertemuan. Pengambilan data dilakukan dengan menggunakan tes hasil belajar dan observasi. Data hasil belajar yang terkumpul dianalisis dengan menggunakan analisis kuantitatif dan data hasil observasi dianalisis secara kualitatif. Hasil penelitian menunjukkan bahwa skor rata-rata murid pada siklus I adalah 60,66, sedangkan pada siklus II diperoleh skor rata-rata 78. Standar KKM yang digunakan di sekolah adalah 65, hal ini menunjukkan bahwa telah tercapai hasil belajar murid secara klasikal. Dari hasil penelitian ini dapat disimpulkan bahwa dengan menerapkan metode Tutor Sebaya kualitas pembelajaran Matematika pada murid kelas IV SDN Topa Baubau dapat meningkat. Kata kunci: Metode Tutor Sebaya. Kualitas Pembelajaran Matematika.

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30

Lucke-Wold, Brandon, Aclan Dogan, Justin Cetas, William Cameron, and Jeremy Ciporen. "Endoscopic Endonasal Transclival Approach versus Dual Transorbital Port Technique for Clip Application to the Posterior Circulation: A Cadaveric Anatomical and Cerebral Circulation Simulation Study." Journal of Neurological Surgery Part B: Skull Base 38, no. 03 (2016): 235–44. http://dx.doi.org/10.1055/s-0036-1597278.

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Purpose Simulation training offers a useful opportunity to appreciate vascular anatomy and develop the technical expertise required to clip intracranial aneurysms of the posterior circulation. Materials and Methods In cadavers, a comparison was made between the endoscopic transclival approach (ETA) alone and a combined multiportal approach using the ETA and a transorbital precaruncular approach (TOPA) to evaluate degrees of freedom, angles of visualization, and ergonomics of aneurysm clip application to the posterior circulation depending on basilar apex position relative to the posterior clinoids. Results ETA alone provided improved access to the posterior circulation when the basilar apex was high riding compared with the posterior clinoids. ETA + TOPA provided a significantly improved functional working area for instruments and visualization of the posterior circulation for a midlevel basilar apex. A single-shaft clip applier provided improved visualization and space for instruments. Proximal and distal vascular control and feasibility of aneurysmal clipping were demonstrated. Conclusions TOPA is a medial orbital approach to the central skull base; a transorbital neuroendoscopic surgery approach. This anatomical simulation provides surgical teams an alternative to the ETA approach alone to address posterior circulation aneurysms, and a means to preoperatively prepare for intraoperative anatomical and surgical instrumentation challenges.

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31

Bachar, Amit, Elad Itzhaki, Shmuel Gleizer, Melina Shamshoom, Ron Milo, and Niv Antonovsky. "Point mutations in topoisomerase I alter the mutation spectrum in E. coli and impact the emergence of drug resistance genotypes." Nucleic Acids Research 48, no. 2 (2019): 761–69. http://dx.doi.org/10.1093/nar/gkz1100.

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Abstract Identifying the molecular mechanisms that give rise to genetic variation is essential for the understanding of evolutionary processes. Previously, we have used adaptive laboratory evolution to enable biomass synthesis from CO2 in Escherichia coli. Genetic analysis of adapted clones from two independently evolving populations revealed distinct enrichment for insertion and deletion mutational events. Here, we follow these observations to show that mutations in the gene encoding for DNA topoisomerase I (topA) give rise to mutator phenotypes with characteristic mutational spectra. Using genetic assays and mutation accumulation lines, we find that point mutations in topA increase the rate of sequence deletion and duplication events. Interestingly, we observe that a single residue substitution (R168C) results in a high rate of head-to-tail (tandem) short sequence duplications, which are independent of existing sequence repeats. Finally, we show that the unique mutation spectrum of topA mutants enhances the emergence of antibiotic resistance in comparison to mismatch-repair (mutS) mutators, and leads to new resistance genotypes. Our findings highlight a potential link between the catalytic activity of topoisomerases and the fundamental question regarding the emergence of de novo tandem repeats, which are known modulators of bacterial evolution.

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Nakamura, Nobuhumi, Takamitsu Kohzuma, Hiro Kuma, and Shinnichiro Suzuki. "The first topa-containing copper(II) complex, [Cu(DL-topa)(bpy)(H2O)]BF4.3H2O, as a model for the active site in copper-containing amine oxidase." Journal of the American Chemical Society 114, no. 16 (1992): 6550–52. http://dx.doi.org/10.1021/ja00042a040.

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Tse-Dinh, Yuk-Ching. "Increased Sensitivity to Oxidative Challenges Associated with topA Deletion in Escherichia coli." Journal of Bacteriology 182, no. 3 (2000): 829–32. http://dx.doi.org/10.1128/jb.182.3.829-832.2000.

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ABSTRACT Deletion of topA in Escherichia coli was found to result in a higher level of killing after treatment with either hydrogen peroxide or N-ethylmaleimide. This effect on oxidative challenge response represents a new role for E. coli DNA topoisomerase I in addition to prevention of excessive negative supercoiling of DNA.

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Ruggiero, Christy E., and David M. Dooley. "Stoichiometry of the Topa Quinone Biogenesis Reaction in Copper Amine Oxidases†." Biochemistry 38, no. 10 (1999): 2892–98. http://dx.doi.org/10.1021/bi9824994.

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35

Ziegler, Gary R., and J. McKim Malville. "Choquequirao, Topa Inca's Machu Picchu: a royal estate and ceremonial center." Proceedings of the International Astronomical Union 7, S278 (2011): 162–68. http://dx.doi.org/10.1017/s1743921311012580.

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AbstractWe provide a history and description of the Inca archaeological complex of Choquequirao, located high on a narrow ridge above the Apurimac River in a remote region of the Vilcabamba of Peru. We suggest that Choquequirao was built as a royal estate during the late 15th century by the Inca ruler, Topa Inca Yupanki, modeled after Machu Picchu. It was built in part by workers imported from Cachapoyas in Northern Peru. The site has alignments with the June and December solstices suggesting a strong solar focus and year-round ceremonial activities. A large truncated hill served as a ceremonial platform or ushnu. The platform was accessed through a double-jamb entranceway, indicating that passage was probably limited to those of high status. We suspect Choquequirao functioned as a ceremonial center. It shares with Machu Picchu the remoteness, ‘other worldliness’, and liminality that are found in many pilgrimage centers of the world. Though Choquequirao, high above the Apurimac River, has a location that is equally as dramatic as Machu Picchu, it lacks the formable geological material required to create imperial-style monumental structures and shaped stone huacas. Choquequirao was occupied during the early colonial years by the Neo-Inca, and was abandoned sometime after the death of the last Inca in 1572. It is a fascinating puzzle that Spanish travelers of the time apparently never reached or described this major Inca complex, which was the most impressive in the Vilcabamba. Somehow, the Inca managed to keep it secret although relatives and others journeyed back and forth to colonial Cusco.

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Ruggiero, Christy E., and David M. Dooley. "Stoichiometry of the Topa Quinone Biogenesis Reaction in Copper Amine Oxidases." Biochemistry 38, no. 29 (1999): 9556. http://dx.doi.org/10.1021/bi9950802.

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Nakamura, Nobuhumi, Takamitsu Kohzuma, Hiro Kuma, and Shinnichiro Suzuki. "Synthesis and structure of a topa containing ternary copper(II) complex." Journal of Inorganic Biochemistry 47, no. 3-4 (1992): 54. http://dx.doi.org/10.1016/0162-0134(92)84142-a.

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Broccoli, Sonia, Pauline Phoenix, and Marc Drolet. "Isolation of the topB gene encoding DNA topoisomerase III as a multicopy suppressor of topA null mutations in Escherichia coli." Molecular Microbiology 35, no. 1 (2000): 58–68. http://dx.doi.org/10.1046/j.1365-2958.2000.01671.x.

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39

Grabowska, Monika, and Witold Ucherek. "Monika Sułkowska (red.) Frazeologia somatyczna w ćwiczeniach." Neofilolog, no. 56/1 (March 31, 2021): 141–49. http://dx.doi.org/10.14746/n.2021.56.1.10.

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Katowice: Wydawnictwo Uniwersytetu Śląskiego, 2019, t. 1: A. Dolata-Zaród, D. Topa-Bryniarska, Język francuski, t. 2: A. Gwiazdowska, Z. Lamba, Język hiszpański, t. 3: L. Marcol-Cacoń, A. Pastucha-Blin, Język włoski.

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Jubair, T. A., U. Salma, N. Haque, et al. "Callus Induction and Regeneration of Local Rice (Oryza sativa L.) Variety Topa." Asian Journal of Plant Sciences 7, no. 5 (2008): 514–17. http://dx.doi.org/10.3923/ajps.2008.514.517.

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Mura, Anna, Alessandra Padiglia, Rosaria Medda, Francesca Pintus, Alessandro Finazzi Agrò, and Giovanni Floris. "Properties of copper-free pig kidney amine oxidase: Role of topa quinone." FEBS Letters 580, no. 18 (2006): 4317–24. http://dx.doi.org/10.1016/j.febslet.2006.06.089.

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Gabor, B. K., F. B. Guillemet, and M. D. Coffey. "Comparison of Field Resistance to Phytophthora cinnamomi in Twelve Avocado Rootstock." HortScience 25, no. 12 (1990): 1655–56. http://dx.doi.org/10.21273/hortsci.25.12.1655.

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Twelve avocado (Persea americana Mill.) rootstock selections were tip-grafted with a commercial scion, cv. Hass, and evaluated for their field resistance to Phytophthora cinnamomi Rands. Percentage difference in trunk cross-sectional area of the inoculated compared to uninoculated rootstock, the overall growth in trunk cross-sectional area, and visual rating of disease severity of the commercial scion were used to evaluate rootstock over 79 weeks. Avocado trees on the rootstock selections Thomas, Martin Grande (G75Sa, b, and c), Barr Duke, and D9 demonstrated the highest level of resistance to P. cinnamomi, whereas those on Topa Topa, Borchard, and G6 had the lowest levels. Trees on Duke 7, G1033, and Toro Canyon rootstock were intermediate in their levels of resistance. Among uninoculated rootstock, trees on Thomas and G6 exhibited the greatest growth in trunk cross-sectional area. whereas those on D9 showed the least.

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Beltrán Ulate, Esteban Josué. "θεός como otredad: una lectura del pensamiento aristotélico". Universitas Philosophica 33, № 67 (2016): 183–99. http://dx.doi.org/10.11144/javeriana.uph33-67.topa.

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La investigación asume el estudio de la “otredad” en el pensamiento aristotélico, profundizando el carácter del θεός. Se procura responder a la pregunta: ¿Qué es “otro” (ἄλλος)? y ¿Cómo es entendida la otredad (ἑτερότης) por Aristóteles? para así, en un último escenario. esbozar una reflexión a propósito de θεός como otredad (ἑτερότης), radicalizando las tesis aristotélicas.

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Guerra, Paula, Maria Carolina De Godoy, and Patrícia Marcondes De Barros. "“Visões à Margem e além-mar”: a literatura marginal brasileira na perspectiva de Heloísa Buarque de Hollanda e de Francisco Topa." Travessias 14, no. 2 (2020): 7–14. http://dx.doi.org/10.48075/rt.v14i2.25503.

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Entrevistas realizadas em meio digital por Maria Carolina de Godoy (UEL/Letras), Patrícia Marcondes de Barros (UEL/História) e Paula Guerra (FLUP/Letras) com Heloísa Buarque de Hollanda (27 de abril de 2020) e Francisco Topa (06 de julho de 2020) sobre a literatura marginal/periférica brasileira.

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GÖRAL, Kemal. "2014 FIFA Dünya Kupasının Başarılı Takımlarında Pas Başarı Yüzdeleri ve Topa Sahip Olma." International journal of Science Culture and Sport 3, no. 9 (2015): 86. http://dx.doi.org/10.14486/ijscs239.

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Lesley, S. A., S. B. Jovanovich, Y. C. Tse-Dinh, and R. R. Burgess. "Identification of a heat shock promoter in the topA gene of Escherichia coli." Journal of Bacteriology 172, no. 12 (1990): 6871–74. http://dx.doi.org/10.1128/jb.172.12.6871-6874.1990.

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ÇOBAN, Oktay. "UEFA AVRUPA LİGİ FİNAL MAÇLARINDA TOPA SAHİP OLMA VE PAS ORANLARININ KAZANMAYA ETKİSİ." Journal of Academic Social Sciences 76, no. 76 (2018): 538–44. http://dx.doi.org/10.16992/asos.14003.

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48

Bossa, M., I. Gelsomino, G. O. Morpurgo, L. Morpurgo, and A. Talamo. "PQQ or TOPA? A theoretical suggestion for the organic cofactor of amine oxidases." Journal of Molecular Structure: THEOCHEM 254 (February 1992): 533–38. http://dx.doi.org/10.1016/0166-1280(92)80095-4.

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49

Tse-Dinh, Yuk-Ching, and James C. Wang. "Complete nucleotide sequence of the topA gene encoding Escherichia coli DNA topoisomerase I." Journal of Molecular Biology 191, no. 3 (1986): 321–31. http://dx.doi.org/10.1016/0022-2836(86)90129-4.

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Amado Gonzales, Donato. "Don Melchor Carlos Inca, el inca mestizo: Los Carlos Inca en el siglo XVII de la sociedad cusqueña." Allpanchis 46, no. 83-84 (2019): 39–67. http://dx.doi.org/10.36901/allpanchis.v46i83-84.264.

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En 1539, don Cristóbal Paullo, uno de los hijos del inca Huayna Cápac, fue nombrado «inca» como parte de una estrategia política de los españoles. Desde entonces tuvo acceso a encomiendas de indios. Don Cristóbal se casó con doña Catalina Tocto Oxica y tuvieron dos hijos: don Carlos Inquill Topa y don Felipe Inquill Topa. Don Carlos Inquil Topa se casó con doña María Esquivel Amarilla y tuvieron un solo hijo llamado Melchor Carlos Inca. El nacimiento de Melchor fue visto por la población nativa como un gran acontecimiento pues había nacido un «rey inca», el cual incluso llegó a ser temido por los funcionarios españoles coloniales al saber que se referían a él como «Cápac Inca». Don Melchor Carlos Inca se identificaba como nieto de don Cristóbal Paullo Inca y bisnieto del inca Huayna Cápac. Se convirtió en un personaje importante dentro de la sociedad virreinal cusqueña. Don Melchor fue bautizado y se casó con doña Leonor Arias Carrasco, hija del conquistador Pedro Alonso Carrasco, ambos eventos fueron significativos para la sociedad cusqueña. La encomienda de Pichigua, de propiedad de don Melchor, era de mucha importancia económica y social, por ello para mantener esta encomienda y sus actividades sociales/políticas, se vio obligado a vender e hipotecar por vía de censo parte de su patrimonio. En 1599, el virrey Luis de Velasco dio una comisión al capitán Antonio Pereira (regidor perpetuo) para averiguar la ascendencia y los servicios de los ancestros de don Melchor. En 1603, don Melchor viajó a España para reclamar sus privilegios y logró su inclusión como Caballero de la Orden de Santiago. La descendencia de Cristóbal Paullo Inca logró establecer y constituir la capilla de Nuestra Señora de Guadalupe en el convento e iglesia de San Francisco, donde tuvieron el honor de tener una bóveda funeraria, la cual fue cuidada y mantenida por sus descendientes hasta el siglo XVII.  Abstract In 1539, don Cristobal Paullo, one of the sons of the Inca ruler Huayna Capac, was named «Inca» as a political strategy of the Spaniards. Since then, he received an encomienda. Don Cristobal was married to doña Catalina Tocto Oxica and had two sons, don Carlos Inquill Topa and don Felipe Inquill Topa. Don Carlos Inquil Topa married doña Maria Esquivel Amarilla and had only one son named Melchor Carlos Inca. The birth of Melchor was seen by the native population as a great event because an “Inca king” had been born, he even became feared by the colonial Spanish officials when they knew he was referred as the «Capac Inca». Don Melchor Carlos Inca identified himself as grandson of don Cristobal Paullo Inca and great-grandson of the Inca Huayna Capac. He became an important figure within the Cuzco›s colonial society. Don Melchor was baptized and married doña Leonor Arias Carrasco, daughter of the Spanish conquistador Pedro Alonso Carrasco, both events were meaningful for Cusco society. Don Melchors’ encomienda of Pichigua was of great economic and social importance, in order to maintain this encomienda and his social/political activities, he had to sell or mortgage part of his inherited patrimony. In 1599, the Viceroy Luis de Velasco ordered captain Antonio Pereira («regidor perpetuo») to ascertain the ancestry and services of don Mechor and his ancestors. In 1603, don Melchor traveled to Spain in order to claim his privileges and succeeded at obtaining a knighthood in the Order of Santiago. The descendants of Cristóbal Paullo Inca established the Chapel of Our Lady of Guadalupe in the Convent and Church of San Francisco where they had the honour of having a burial vault which was carefully guarded and maintained by their descendants until 17th Century.

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