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Journal articles on the topic 'Topical gel'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Tindale, Rabina. "Topical gel." Emergency Nurse 12, no. 2 (2004): 7. http://dx.doi.org/10.7748/en.12.2.7.s13.

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Ahu, S. T., W. W. Monafo, T. A. Mustoe, and Hal G. Bingham. "Topical silicone gel." Plastic and Reconstructive Surgery 86, no. 3 (1990): 617. http://dx.doi.org/10.1097/00006534-199009000-00099.

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3

Witkowski, Joseph A., and Lawrence Charles Parish. "Topical Metronidazole Gel." International Journal of Dermatology 30, no. 9 (1991): 660–61. http://dx.doi.org/10.1111/j.1365-4362.1991.tb03498.x.

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4

Nielsen, P. Gamborg. "Topical Metronidazole Gel." International Journal of Dermatology 30, no. 9 (1991): 662–66. http://dx.doi.org/10.1111/j.1365-4362.1991.tb03499.x.

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5

Zhu, Z.-H., J. Zheng, L.-Y. Ying, B.-W. Zhu, J. Qian, and Z.-X. Ma. "Cross-over study of topical anaesthesia with tetracaine solution for transoral rigid laryngoscopy." Journal of Laryngology & Otology 126, no. 11 (2012): 1150–54. http://dx.doi.org/10.1017/s002221511200182x.

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AbstractBackground:Transoral rigid laryngoscopy with videostroboscopy is the most practical method to visualise the vocal folds. The optimal topical anaesthesia regimen for transoral rigid laryngoscopy has not yet been established.Objective:To compare patient comfort and compliance with various topical anaesthetics for transoral rigid laryngoscopy.Methods:Each of 10 patients received a random topical administration of either 2 per cent lidocaine gel, 1 per cent tetracaine gel or 1 per cent tetracaine solution, 10 minutes before undergoing rigid laryngoscopy with videostroboscopy. During follow

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Syeda Ayesha Farhana, Nada Abdelrahman Mohamed Ibrahim, Lamya M kassem, and Jamal Moideen Muthu Mohamed. "Topical Hydrogel Formulation of Naproxen: Design and Evaluation for Improved Therapy on Topical Administration." Metallurgical and Materials Engineering 31, no. 4 (2025): 341–47. https://doi.org/10.63278/1442.

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Topical gel compositions are designed to be applied topically or to specific mucosal surfaces in order to provide localised or transdermal drug penetration, as well as emollient or protective properties. Nonsteroidal anti-inflammatory drugs (NSAIDs) are non-steroidal drugs with good analgesic and anti-inflammatory properties; nevertheless, when used orally, NSAIDs can cause GIT ulcers as well as liver and renal problems. Several NSAIDs are now more often applied topically due to the negative pharmacological reaction that oral versions might cause. To prepare topical hydrogel formulations of na

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DiMarco, Arthur C., and Ann O'Kelley Wetmore. "Clinical Comparison: Fast-Acting and Traditional Topical Dental Anesthetic." Anesthesia Progress 63, no. 2 (2016): 55–61. http://dx.doi.org/10.2344/0003-3006-63.2.55.

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A randomized, nonblinded clinical trial compared the effectiveness of an application method of a fast-acting refrigerant topical agent to a 20% benzocaine gel topical. In a split-mouth design, right and left anterior middle superior alveolar injections (N = 30) were administered with a 27-gauge needle at least 24 hours apart with preinjection topicals. Using a cotton-tipped applicator, a refrigerant topical was applied for 5 seconds and 20% benzocaine gel for 2 minutes on opposite sides at 2 separate appointments. Subjects self-reported pain perception after each injection using a visual analo

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Gajendra, Singh Rathore, Singh Tanwar Yuvraj, and Sharma Anshu. "Fluconazole Loaded Ethosomes Gel and Liposomes Gel: An Updated Review for the Treatment of Deep Fungal Skin Infection." Pharmaceutical and Chemical Journal 2, no. 1 (2015): 41–50. https://doi.org/10.5281/zenodo.13692341.

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Skin acts as a major target as well as a principle barrier for topical drug delivery. The greatest challenge for dermal delivery is stratum corneum, and in order to improve its permeability, new formulation approaches have been investigated. The main requirement for topical anti-fungal treatment is that the drugs should penetrate into skin layers to ensure effective drug concentrations following topical administration. Types of the formulations as well as the physicochemical characteristics of drug molecules are effective parameters in topical delivery of drugs. Antifungal drugs should reach e

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Yadav, Sunil Kumar, Manoj Kumar Mishra, Anupamaa Tiwari, and Ashutosh Shukla. "EMULGEL: A NEW APPROACH FOR ENHANCED TOPICAL DRUG DELIVERY." International Journal of Current Pharmaceutical Research 9, no. 1 (2016): 15. http://dx.doi.org/10.22159/ijcpr.2017v9i1.16628.

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Emulgel is used to treat aches and pains caused by colds, headaches, muscle aches, backaches, arthritis and other conditions and injuries. The patient adherence to topical formulations is significant in relation to chronic skin diseases, like fungal infections, acne, psoriasis. Emulgel is one of the recent technology in NDDS used topically having characteristics of dual control release i.e. emulsion as well as gel. Emulgels have emerged as one of the most interesting topical delivery systems as it has dual release control system i.e. gel and emulsion. When gel and emulsion are used in combined

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Rompicherla, Narayana Charyulu, Punam Joshi, Amitha Shetty, et al. "Design, Formulation, and Evaluation of Aloe vera Gel-Based Capsaicin Transemulgel for Osteoarthritis." Pharmaceutics 14, no. 9 (2022): 1812. http://dx.doi.org/10.3390/pharmaceutics14091812.

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Topical treatments are a potential therapeutic option for the therapy of osteoarthritis, with significant data supporting the effectiveness and safety of topical formulation. Topical gel formulations may offer an alternative to oral formulations to relieve osteoarthritis (OA) pain while decreasing systemic exposure. Topical capsaicin transemulgel may represent an effective and safe alternative. The transemulgel was prepared from aqueous Aloe vera gel and Carbopol 934 with capsaicin in clove oil emulsion. The optimized transemulgel of capsaicin showed a pH of 6.1 ± 0.1 and viscosity of 15263–99

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Pandu, Sri P., Sherly Horax, Marhamah Marhamah, and Amelia Amelia. "Differences in Pain between Topical Gel and Chlor Ethyl in Paedodontic Patients before Infiltration Anesthesia." e-GiGi 12, no. 1 (2023): 32–37. http://dx.doi.org/10.35790/eg.v12i1.48420.

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Abstract: Pain control during invasive and non-invasive dental procedures is very important since discomfort can cause patients to refuse treatment. Local anesthesia (LA) is required in any dental practice, including pedodontics, to reduce pain during dental procedures such as extractions, pulpotomy, root canal treatment, pulpectomy, abscess drainage, and minor oral surgical procedures. Application of flavoured topical anesthetic gel is most frequently used in pediatric dentistry. There are various types of topical anesthetics according to the medicinal ingredients in the forms of liquid, gel,

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Mohan, Ajit George, A. V. Rajesh Ebenezar, Mohamed Fayas Ghani, Leena Martina, Ashwin Narayanan, and Bejoy Mony. "Surface and mineral changes of enamel with different remineralizing agents in conjunction with carbon-dioxide laser." European Journal of Dentistry 08, no. 01 (2014): 118–23. http://dx.doi.org/10.4103/1305-7456.126264.

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ABSTRACT Aim: The aim of this study was to evaluate the surface/mineral changes on enamel before and after the application of acidulated phosphate fluoride (APF) gel, fluoride enhanced hydroxyapatite gel and propolis in conjunction with carbon-dioxide (CO2) laser. Materials and Methods: Crowns of 40 human maxillary central incisors were collected and were divided into four groups of 10 each: Topical fluoride application only, topical fluoride application followed by CO2 laser irradiation, CO2 laser irradiation followed by topical fluoride application and CO2 laser irradiation before and after

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Aguiar, Marta Gontijo, Aline Márcia Machado Pereira, Ana Paula Fernandes, and Lucas Antonio Miranda Ferreira. "Reductions in Skin and Systemic Parasite Burdens as a Combined Effect of Topical Paromomycin and Oral Miltefosine Treatment of Mice Experimentally Infected with Leishmania (Leishmania) amazonensis." Antimicrobial Agents and Chemotherapy 54, no. 11 (2010): 4699–704. http://dx.doi.org/10.1128/aac.00809-10.

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ABSTRACT This study aimed to investigate the activity of a combination of topical paromomycin gel and oral miltefosine for the treatment of experimental cutaneous leishmaniasis caused by Leishmania (Leishmania) amazonensis. The efficacy of the combination, evaluated by measuring lesion size and parasite burden in the skin and spleen, was assessed in BALB/c mice infected by L. (L.) amazonensis. The miltefosine was administered orally at 10 mg/kg of body weight/day for 10 days, while 10% paromomycin gel was applied topically twice a day for 20 days. Treatment of the experimentally infected anima

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&NA;. "TOPICAL GEL FOR ADULT ACNE." AJN, American Journal of Nursing 89, no. 6 (1989): 796–97. http://dx.doi.org/10.1097/00000446-198906000-00005.

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15

Kirber, William M. "Lidocaine Gel for Topical Anesthesia." Journal of Cataract & Refractive Surgery 26, no. 2 (2000): 163. http://dx.doi.org/10.1016/s0886-3350(99)00448-4.

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16

Scheinfeld, Noah S. "MetroGel (metronidazole) Topical Gel, 1%." SKINmed: Dermatology for the Clinician 4, no. 5 (2005): 319. http://dx.doi.org/10.1111/j.1540-9740.2005.04866.x.

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Sundari, I. Bala Tripura, P. Akhila P. Akhila, M. Anirudh Surya, K. Sai Prakash Reddy, M. Ajay M. Ajay, and K. Jahnavi Reddy. "Formulation and Evaluation of Diclofenac Diethylamine Gel Using Natural Mucilages." International Journal of Pharmaceutical Research and Applications 10, no. 1 (2025): 1343–48. https://doi.org/10.35629/4494-100113431348.

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Gels have better potential as a vehicle to deliver the drug topically. The present work aimed to study the gelling efficiency of natural mucilages using diclofenac diethylamine used topically for its effective anti-inflammatory and analgesic properties. Diclofenac diethyl amine topical gels were formulated with okra mucilage (2.5-10%), and hibiscus mucilage (2.5-10%) and compared with Carbopol 934 (1-2%). The prepared gel formulations were evaluated for clarity, homogeneity, pH, spreadability, extrudability, and drug content. Formulation F4 containing 10% Hibiscus mucilage as the gelling agent

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18

Krishna Pandey, Sanjay, Jai Narayan Mishra, and Dhaneshwar K. Vishwakarma. "FORMULATION AND EVALUATION OF ANTIFUNGAL TOPICAL GEL OF C. TORA SEED EXTRACT." International Journal of Advanced Research 8, no. 9 (2020): 1352–60. http://dx.doi.org/10.21474/ijar01/11796.

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Purpose: To formulate novel topical antifungal gel containing seed extract of c.tora. and to evaluate their antifungal potential. Method: the gel was formulated by a cold mechanical method. Prepared gel was subjected to various evaluation parameters like ph, viscosity, spread ability, homogeneity and antifungal activity. Results: Prepared topical gel of extract was pH range of 6.25±0.05 to 6.45±0.15, viscosity range 386±27.90 to 680±45.50cp, spread ability 40±2.5 to 38±2 mm and homogenous. Prepared topical gel was shown zone of inhibition ranges from 13.5±0.5 to 23.5±0.5 mm for candida albican

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GÜVEN, Umay Merve, Tilbe ÇEVİKELLİ, Sanem SONGÜLOĞLU, and Serpil DEMİRCİ KAYIRAN. "YANIK TEDAVİSİNDE KULLANILMAK ÜZERE LİDOKAİN İÇEREN ALOE VERA JEL FORMÜLASYONUNUN HAZIRLANMASI VE İN VİTRO KARAKTERİZASYONU." Ankara Universitesi Eczacilik Fakultesi Dergisi 47, no. 3 (2023): 34. http://dx.doi.org/10.33483/jfpau.1319262.

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Objective: In this study, topically applied in situ gel formulations were aimed to design for the modulation of burns, with the active ingredient lidocaine and the gel gained from the Aloe vera plant. The prepared in situ gels were in the liquid form at the room temperature and gelled at the body temperature and adhered to the wound surface, resulting in higher drug residence time. By improving the characteristic properties of the in situ gels, it is aimed to improve patient compliance by obtaining higher local lidocaine concentration. Material and Method: In situ gel formulations separated by

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20

Shinde, Ujwala A., and Shivkumar S. Kanojiya. "Serratiopeptidase Niosomal Gel with Potential in Topical Delivery." Journal of Pharmaceutics 2014 (March 20, 2014): 1–9. http://dx.doi.org/10.1155/2014/382959.

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The objective of present study was to develop nonionic surfactant vesicles of proteolytic enzyme serratiopeptidase (SRP) by adapting reverse phase evaporation (REV) technique and to evaluate the viability of SRP niosomal gel in treating the topical inflammation. The feasibility of SRP niosomes by REV method using Span 40 and cholesterol has been successfully demonstrated in this investigation. The entrapment efficiency was found to be influenced by the molar ratio of Span 40 : cholesterol and concentration of SRP in noisome. The developed niosomes were characterized for morphology, particle si

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21

Nidhi A. Bagmar, Pooja R. Hatwar, Prashant G. Shelke, and Ravindra L. Bakal. "A review on "Topical gels: an emerging drug delivery system”." GSC Biological and Pharmaceutical Sciences 28, no. 2 (2024): 285–96. http://dx.doi.org/10.30574/gscbps.2024.28.2.0311.

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Topical drug distribution is the application of a substance to the skin for the aim of treating or curing skin problems. Gels, creams, and ointments are the most often used semisolid formulations for topical medicine administration. Gels have been popular in cosmetics and topical medicinal treatments in recent years due to their advantageous properties such as being greaseless, easily spreadable, and quickly detachable. In compared to creams and ointments, gel formulations have greater application properties and stability. A gel is a network of cross-linked polymers that expand in a liquid med

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Nidhi, A. Bagmar, R. Hatwar Pooja, G. Shelke Prashant, and L. Bakal Ravindra. "A review on "Topical gels: an emerging drug delivery system"." GSC Biological and Pharmaceutical Sciences 28, no. 2 (2024): 285–96. https://doi.org/10.5281/zenodo.14676776.

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Topical drug distribution is the application of a substance to the skin for the aim of treating or curing skin problems. Gels, creams, and ointments are the most often used semisolid formulations for topical medicine administration. Gels have been popular in cosmetics and topical medicinal treatments in recent years due to their advantageous properties such as being greaseless, easily spreadable, and quickly detachable. In compared to creams and ointments, gel formulations have greater application properties and stability. A gel is a network of cross-linked polymers that expand in a liquid med

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23

Das, Sudipta, Keya Sarkar, Baishali Ghosh, and Chandrima Saha. "Design, Formulation and Evaluation of Diclofenac Diethylamine Gel." Journal of Basic and Applied Research in Biomedicine 8, no. 1 (2022): 4–7. http://dx.doi.org/10.51152/jbarbiomed.v8i1.210.

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The goal of this study was to produce a topical gel formulation of Diclofenac diethylamine using various gelling agents, such as carbopol 934, Sodium Carboxy methyl cellulose, and alovera extract, to reduce the gastrointestinal side effects associated with oral administration. Topical medication administration can be accomplished by integrating into the gel matrix, preventing first-pass metabolism and allowing for greater local action in anti-inflammatory and analgesic purpose. The gel formulations were tested for homogeneity, grittiness, viscosity, pH, spreadability, drug content, in vitro dr

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Shilakari Asthana, Gyati, Abhay Asthana, Davinder Singh, and Parveen Kumar Sharma. "Etodolac Containing Topical Niosomal Gel: Formulation Development and Evaluation." Journal of Drug Delivery 2016 (July 11, 2016): 1–8. http://dx.doi.org/10.1155/2016/9324567.

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The present study aimed to investigate the delivery potential of Etodolac (ETD) containing topical niosomal gel. Niosomal formulations were prepared by thin film hydration method at various ratios of cholesterol and Span 60 and were evaluated with respect to particle size, shape, entrapment efficiency, and in vitro characteristics. Dicetyl phosphate (DCP) was also added in the niosomal formulation. Mean particle size of niosomal formulation was found to be in the range of 2 μm to 4 μm. Niosomal formulation N2 (1 : 1) ratio of cholesterol and surfactant displayed good entrapment efficiency (96.

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Anggraini, Nadia Bunga, Berna Elya, and Iskandarsyah Iskandarsyah. "Antielastase Activity of Macassar Kernels (Rhus javanica) Stem Extract and Skin Elasticity Evaluation of Its Topical Gel Formulation." Advances in Pharmacological and Pharmaceutical Sciences 2021 (April 21, 2021): 1–11. http://dx.doi.org/10.1155/2021/6690029.

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Background. Macassar kernels (Rhus javanica L.) has potential as an antiaging agent as it has antielastase activity, especially its stem extract which has best percent inhibition compared to its leaves and fruit extract. Moreover, the antiaging agent can be commonly used in the form of gel for topical applications. Hence, formulation of HEC-based topical gel from the stem extract of Macassar kernels was conducted. This study aims to determine the antielastase activity of the stem extract of Macassar kernels and evaluate the skin elasticity of its topical gel formulation by conducting dermatolo

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Ismail, I. Maged, Brian Baker, Richard Matsumoto, et al. "Subchronic and Chronic Toxicity of Tazarotene Gel Following Topical Application in Hanford Miniswine." International Journal of Toxicology 16, no. 6 (1997): 571–84. http://dx.doi.org/10.1080/109158197226892.

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Tazarotene, a member of a novel class of synthetic acetylenic retinoids, is the first topical retinoid to demonstrate both efficacy and an acceptable patient tolerability profile in the treatment of psoriasis. The subchronic and chronic toxicity of topically applied tazarotene gel (0.025-0.1%; 0.05-0.5 mg/kg/d) was evaluated in Hanford miniswine in two separate, prospective, randomized, vehicle-controlled studies of 3 months' and 12 months' duration. Although tazarotenic acid, the active metabolite of tazarotene, was detected in the blood of animals in both studies, no signs of systemic toxici

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AL-mosawi, Raniah OA, Jubran K. Hassan, and Firas F. AL-tameemi. "Comparative Evaluation of Topical Antibiotics in Treatment of Mild to Moderate Acne Vulgaris." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 04 (2022): 1924–27. http://dx.doi.org/10.25258/ijddt.12.4.74.

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is a pleomorphic disease and can happen during any age in life most commonly present in teenagers between 14–25 years old with prevalence ranging from 50–95% in different populations worldwide. Acne vulgaris considered a benign condition but can have an important psychological effect on the patient because it targets mostly the most important part of the human body which is the face of young patients. Clindamycin topical gel and erythromycin topical gel is effective in the treatment of acne vulgaris by acting against gram- positive propionibacterium acnes. FDA has approved dapsone topical gel

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Tayal, Shivam, Pradyumn Tiwari, Vinod Sahu, and Shivang Sharma. "Preparation and Characterization of an Antiviral Gel." International Journal of Pharma Professional’s Research (IJPPR) 14, no. 4 (2023): 150–56. http://dx.doi.org/10.48165/ijppronline.2023.14413.

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The study was to develop an antiviral gel for topical application. The topical application of drug has many advantages over the intravenous and oral administration. It prevents metabolism of drug from liver and avoid the risk of gastrointestinal disorder and inconvenience of intravenous therapy pain. When the drug is applied topically it can penetrate deeper into the skin hence show better absorption and bioavailability. The wide varieties of pharmaceutical dosage form are available for topical drug delivery system. The most used one is gel, ointment and cream. Herpes Simplex Virus (HSV) is wi

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Mohammed, Nawres Bahaa, Malath Azeez Alsaadi, Safaa Sahib Naji Sultan, and Adil Aliakbar. "Effect of 0.2% Hyaluronic Acid Gel Topical Application on Healing Period of Oroantral Fistula Treated with Buccal Flap." Open Access Macedonian Journal of Medical Sciences 8, no. D (2020): 194–97. http://dx.doi.org/10.3889/oamjms.2020.5157.

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BACKGROUND: Oroantral fistula (OAF) is a pathological communication between maxillary sinus and oral cavity, which treated by various surgical methods including buccal flap and associated with post-operative discomfort and relatively long healing period. AIM: The objective of the study was to evaluate the effect of 0.2% hyaluronic acid (HA) gel on the healing period after surgical buccal flap treatment of OAF. METHODS: The records of 20 patients of both genders included and reviewed retrospectively. Ten patients treated with topical 0.2% HA gel while the other 10 patients treated w

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Zhang, Yun, Sijia Li, Yanfang Huang, Congjing Song, Weiqiang Chen, and Yiling Yang. "Therapeutic Effect of Liquiritin Carbomer Gel on Topical Glucocorticoid-Induced Skin Inflammation in Mice." Pharmaceutics 16, no. 8 (2024): 1001. http://dx.doi.org/10.3390/pharmaceutics16081001.

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Glucocorticoids are often used and highly effective anti-inflammatory medications, but prolonged topical application may alter the epidermis’ normal structure and function, potentially resulting in a number of adverse effects. Topical glucocorticoid-induced skin inflammation is a dangerous condition that develops after topical glucocorticoid use. The patients become dependent on the medication and, even after the medication is stopped, the dermatitis symptoms recur, severely impairing their quality of life. Thus, the need to aggressively confront Topical glucocorticoid-induced skin inflammatio

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Kusumawinakhyu, Titik, Edi Dharmana, Taufiqurrachman Nasihun, Chodidjah Chodidjah, and Dwi Pudjonarko. "Kefir Gel Increased The Epithelial Thickness in First-Degree Sunburn." Bali Medical Journal 10, no. 3 (2021): 1354–56. http://dx.doi.org/10.15562/bmj.v10i3.3017.

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Background: UVB radiation may cause skin to experience acute symptoms such as erythema and pain. The acute symptoms are categorized as first-degree sunburn. Prevention can be done through kefir gel administration.Purpose: This study aimed to determine differences between effect kefir oral, topical gel, and combination (oral and topical gel) effects and the negative control group on epithelial thickness in first-degree sunburn. Method: An experimental study with post-test only control group design was conducted on BALB/c mice, and the negative control group exposed only with UVB without kefir a

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Niraj, Kumar, and Saxena Charu. "A Novel Approach for Topical Drug Delivery System–Emulgel." Trends in Pharmaceuticals and Nanotechnology 1, no. 2 (2019): 27–32. https://doi.org/10.5281/zenodo.3359349.

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<em>There are various advantages in topical route over the other route of administration. It is a topical drug delivery system. The most important route is gels which provide faster drug release compared with other topical drug delivery, but gel has a limitation that it is used only for hydrophobic drugs; this can be overcome by Emulgels. Emulgels are a type of emulsion may be oil in water or water in oil type; they are incorporated into gelling agent. Emulgel is more effective than regular gel in various aspects and permeation of drug in emulgel is more compared to normal gel. Permeation enha

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Talele, S. G., L. T. Gadhe, P. Hire, S. V. Kapadi, and G. N. Chaudhari. "FORMULATION AND EVALUATION OF TOPICAL MICROEMULSION GEL OF KARANJA OIL." INDIAN DRUGS 53, no. 07 (2016): 35–41. http://dx.doi.org/10.53879/id.53.07.10328.

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The purpose of this study was to formulate topical microemulsion gel of karanja oil suitable for topical delivery. Karanja oil microemulsion system with Tween 80 as surfactant, PEG 400 as cosurfactant and karanja oil as oil was developed for topical delivery. Pseudo-ternary phase diagrams were constructed to identify the microemulsion region and a suitable composition was identified to formulate the microemulsion. Single isotropic region, which is considered as an o/w microemulsion, was found in the pseudo-ternary phase diagrams developed at various Tween 80 and PEG 400 ratios using phase titr

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Singhvi, Gautam, Shalini Patil, Vishal Girdhar, and Sunil Kumar Dubey. "Nanocarriers for Topical Drug Delivery: Approaches and Advancements." Nanoscience & Nanotechnology-Asia 9, no. 3 (2019): 329–36. http://dx.doi.org/10.2174/2210681208666180320122534.

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Background:Delivery of drugs through the skin has been an attractive as well as a challenging area for research. Topical drug delivery has provided enormous advantages over the systemic route for various drugs and one of the important amongst them is reduced toxicity due to a minimum or zero exposure to non-target organs.Methods:Various nanocarrier loaded topical preparations including organogels, emulgels, niosomal gel, lyotropic liquid crystal based gels, etc have been investigated for their topical application. Nanocarriers loaded topical preparation have been proven for improved permeation

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Maganur, Prabhadevi C., Atiah Abdulrahman Ghawi, Ghadi DuhDuh Arishi, et al. "A Comparative Study on Pain Perception in Children, After Application of Pre-Cooled and Plain Topical Anaesthetic Gel During Local Anaesthetic Administration—A Parallel Three-Arm Randomised Control Trial." Children 12, no. 7 (2025): 863. https://doi.org/10.3390/children12070863.

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Background: Effective pain management in children is essential, particularly when administering local anaesthesia. This study was undertaken to compare pain perception in children after application of pre-cooled and plain topical anaesthetic gel during local anaesthetic administration. Methods: A randomised, single-blinded controlled trial was conducted among 51 children between the ages of 6 and 12, visiting the paediatric clinic, Jazan (REC-45/10/1070). Children were allocated into one of the following three groups using a simple randomisation having a 1:1:1 allocation ratio into Group I (n

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Berlian, Mukti Arja, Iffan Alif, Prasetyowati Subchan, et al. "Topical Gel of Mesenchymal Stem Cell-Conditioned Medium-induced Serum Injury Accelerates Wound Healing in Skin Excision Tissue." International Journal of Cell and Biomedical Science 1, no. 1 (2022): 10–17. https://doi.org/10.59278/cbs.v1i1.12.

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Introduction: Umbilical cord-derived mesenchymal stem cells (UC-MSCs) accelerating wound closure by increasing VEGF and PDGF level leading to re-epithelialization, cell infiltration, and angiogenesis. It has been found that MSC-conditioned medium (MSC-CM) can enhance migration of fibroblasts in scratch assays. However, the effect of MSC-CM-induced serum injury (MSC-CM-S) formulated in gel to accelerate wound healing remains unclear. This study aims to evaluate the effect of several doses of topical gel of MSC-CM-S in accelerating wound healing. Methods: The MSCs were cultured medium-supplement

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Kuswahyuning, Rina, and Indra Lesmana. "Formulation and Evaluation of Mangosteen (Garcinia mangostana L.) Fruit Pericarp Extract Gel." Jurnal Kefarmasian Indonesia 11, no. 2 (2021): 90–97. http://dx.doi.org/10.22435/jki.v11i2.3701.

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The topical antioxidant product may be useful for the treatment of oxidative stress-related skin disorder. This research aimed to evaluate a topical gel formulation of Garcinia mangostana L. fruit pericarp (GMP) extract. GMP extract was formulated into a gel and characterized for its physical properties. The antioxidant activity was evaluated based on the radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity. The ability of gel formulation to release GMP extract and promote skin delivery was estimated based on DPPH scavenging method and also compared to that of suspension form. The

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Gajinov, Zorica. "Corticosteroid topical therapy range: Fluocinolone-acetonide gel." Galenika Medical Journal 1, no. 2 (2022): 17–22. http://dx.doi.org/10.5937/galmed2202017g.

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Since the early days of use, in the mid of twentieth century, topical corticosteroids became the basis of contemporary dermatological therapy, because of their antiinflammatory efficiency, comfort of application free from unpleasant characteristics of previous generations of dermatotherapeutics, tar or antralin. With numerous evidences about potencies of specific corticosteroid molecules for adverse effects, optimal and efficient use of topical corticosteroid is the empiric art of dermatology, based on precise diagnosis, knowledge about the pathophysiology of dermatosis and characteristics of

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Bhaiyyasaheb, Kokare*1 Dr. Priti Shinde2. "Formulation and Evalution of Diclofenac Gel." International Journal of Scientific Research and Technology 2, no. 5 (2025): 658–64. https://doi.org/10.5281/zenodo.15564144.

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The present study focuses on the formulation and development of a topical gel containing diclofenac sodium for the treatment of localized musculoskeletal pain and inflammation. Diclofenac, a non-steroidal anti-inflammatory drug (NSAID), is widely used due to its potent analgesic and anti-inflammatory properties. The goal was to enhance the topical delivery of diclofenac through an effective gel formulation, thereby minimizing systemic side effects associated with oral administration. Various gel formulations were prepared using different concentrations of gelling agents such as Carbopol 934 an

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Hasanah, Santi, and Jessie Sofia Pamudji. "REVIEW: POTENTIAL OF NANOEMULGEL FORMULATIONS FOR TOPICAL DRUG DELIVERY." Medical Sains : Jurnal Ilmiah Kefarmasian 9, no. 2 (2024): 433–44. http://dx.doi.org/10.37874/ms.v9i2.1182.

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Nanoemulgel is a combination of two different formulation systems, known as nanoemulsion preparation with gel matrix. In recent years, there has been an increase in the use of topical nanoemulgel preparations because they are easy to apply and can avoid damage to various drugs in the body. Although topical nanoemulgel preparations have some limitations, they are capable of delivering lipophilic drugs topically. The purpose of this review is to summarize the potential of nanoemulgel formulations for topical drug delivery against various physiological challenges and limitations of the formula. T

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Samia-Aly, Emma, and Faye Mellington. "Topical silicone gel mistaken for a retained orbital foreign body on MRI." BMJ Case Reports 15, no. 3 (2022): e248103. http://dx.doi.org/10.1136/bcr-2021-248103.

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MRI is now a well-regarded imaging technique, but due to its use of strong magnetic fields, some metallic objects are contraindicated. We present a case of a man in his 40s with thyroid eye disease, who underwent bilateral orbital decompression. Following surgery, he was advised to start scar massage with topical silicone gel (Dermatix). He later underwent an MRI head scan which was halted due to concerns of a retained metallic foreign body. Topical silicone gel is widely used clinically for scar management. Due to its properties, it can cause the appearance of an artefact on MRI and be mistak

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Muktai N. Rudrurkar, Vishweshwar M. Dharashive, Dr. Sameer Shafi, and Anis J. Kazi. "Development and characterization of Luliconazole Loaded Solid Lipid Nanoparticles for Topical Delivery." Asian Journal of Pharmaceutical Research and Development 12, no. 6 (2024): 43–55. https://doi.org/10.22270/ajprd.v12i6.1458.

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Superficial fungal infections in immunocompromised patients can lead to various disorders and complications. There is a critical need for new topical treatment options for these fungal infections. Luliconazole (LUZ) is a topical antifungal medicine used to treat fungal infections. This paper aims to develop a new topical gel incorporating Luliconazole SLN (LUZ-SLN). The study suggests that LUZ-SLN embedded in a gel could serve as an effective drug delivery system for topical antifungal treatments. Initial experiments were conducted to characterize the LUZ-SLN and compare it with the raw drug.

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Chaudhari, Urvashi R., Chauhan Jaydeep, Vyas Jigar, and Ghodkar Janhvi. "Herbal radish and carrot topical gel." RESEARCH JOURNAL OF TOPICAL AND COSMETIC SCIENCES 11, no. 2 (2020): 65–69. http://dx.doi.org/10.5958/2321-5844.2020.00012.6.

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Dipti, Padhan K., Samantaray Kiran, Mohanty Arnabaditya, and Padhan Jyotirmayee. "TOPICAL ANALGESIC ACTIVITY OF CLOVE GEL." Journal of Harmonized Research in Pharmacy 6, no. 4 (2018): 84. http://dx.doi.org/10.30876/johr.7.4.2018.84-88.

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Dmochowski, Roger R., Diane K. Newman, Peter K. Sand, et al. "Pharmacokinetics of Oxybutynin Chloride Topical Gel." Clinical Drug Investigation 31, no. 8 (2011): 559–71. http://dx.doi.org/10.2165/11588990-000000000-00000.

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WENDLING, PATRICE. "Novel Topical Gel Treats Overactive Bladder." Caring for the Ages 10, no. 12 (2009): 10. http://dx.doi.org/10.1016/s1526-4114(09)60322-x.

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JANCIN, BRUCE. "Topical Botulinum Gel in Developmental Pipeline." Skin & Allergy News 41, no. 4 (2010): 9. http://dx.doi.org/10.1016/s0037-6337(10)70073-5.

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Wendling, Patrice. "Topical Gel Offers Overactive Bladder Option." Family Practice News 39, no. 11 (2009): 33. http://dx.doi.org/10.1016/s0300-7073(09)70445-1.

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McNamara, Damian. "Topical Dapsone Gel Engenders Screening Requirement." Skin & Allergy News 36, no. 12 (2005): 32. http://dx.doi.org/10.1016/s0037-6337(05)70884-6.

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Danielsson, I., T. Torstensson, G. Brodda-Jansen, and N. Bohm-Starke. "EMG Biofeedback Versus Topical Lidocaine Gel." Journal of Lower Genital Tract Disease 11, no. 3 (2007): 194. http://dx.doi.org/10.1097/01.lgt.0000265792.87483.a2.

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