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Journal articles on the topic 'Topical Olopatadine (0.1%)'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

Kumar L, Kiran, and M. S. Smitha Gowda. "Comparison of efficacy of topical alcaftadine (0.25%) versus olopatadine (0.1%) in allergic conjunctivitis." Indian Journal of Clinical and Experimental Ophthalmology 7, no. 4 (2022): 630–33. http://dx.doi.org/10.18231/j.ijceo.2021.126.

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The most common atopic ocular condition in clinical practice is allergic conjunctivitis. One of the preferred treatment options for allergic Conjunctivitis is anti histamines eye drops. The study purpose is to compare the clinical efficacy between topical alcaftadine 0.25% and olopatadine hydrochloride 0.1% in allergic conjunctivitis patients.A prospective, randomized, open label, parallel group, comparative study was conducted on 60 Patients with bilateral allergic conjunctivitis (30 in each group) after taking an informed written consentand was evaluated from May 2018 to November 2018. Patie

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Prashant, Kumar, and Verma Anurag. "Comparative Research on the Effectiveness and Safety of LongActing Antihistamines in Allergic Conjunctivitis in Indian Patients: An RCT Trial." International Journal of Pharmaceutical and Clinical Research 13, no. 4 (2021): 181–87. https://doi.org/10.5281/zenodo.14201914.

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<strong>Aim:</strong> The aim of the present study was to compare the safety and efficacy of Alcaftadine 0.25%, Olopatadine hydrochloride 0.2% and Bepotastine besilate 1.5% in allergic conjunctivitis. <strong>Methods:</strong> A total of 90 patients with mild or moderate allergic conjunctivitis were randomized into three groups with an allocation ratio of 1:1:1 using computer-generated random number sequence to receive topical anti-allergic medication for 14 days as Group 1: Topical 0.25% Alcaftadine eye drops OD, Group 2: Topical 0.2% Olopatadine eye drops OD and Group 3: Topic

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Renuka, Ranjan Alok, and Kumar Sinha Ajay. "Comparative Assessment of Alcaftadine 0.25%, Olopatadine Hydrochloride 0.2% and Bepotastine Besilate 1.5% as AntiAllergic Conjunctivitis Agents." International Journal of Pharmaceutical and Clinical Research 13, no. 6 (2021): 412–19. https://doi.org/10.5281/zenodo.14218171.

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<strong>Aim:</strong> The aim of the present study to compare the safety and efficacy of Alcaftadine 0.25%, Olopatadine hydrochloride 0.2% and Bepotastine besilate 1.5% in allergic conjunctivitis. <strong>Methods: </strong>A total of 90 patients with mild or moderate allergic conjunctivitis were randomized into three groups with an allocation ratio of 1:1:1 using computer‑generated random number sequence to receive topical anti-allergic medication for 14 days as Group 1: Topical 0.25% Alcaftadine eye drops OD, Group 2: Topical 0.2% Olopatadine eye drops OD and Group 3: Topical 1

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V. Manekar, Archana, and Sharayu Ashok Bhore. "A Comparative Study of Olopatadine Hydrochloride and Bepotastine Besilate in the Treatment of Allergic Conjunctivitis." International Journal of Research and Review 9, no. 3 (2022): 166–72. http://dx.doi.org/10.52403/ijrr.20220320.

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Background -Ocular allergy is a commonly encountered pathology in clinical practice, which often is under diagnosed and consequently undertreated. These are rarely vision-threatening but can significantly decrease the quality of life for patients. Olopatadine and Bepotastine eyedrop have both antihistaminic and mast cell stabilization action. Their use can control acute symptoms and prevent relapses as well. We conducted this single blinded trial directly comparing the efficacy of the two topical anti allergic medications in mild forms of allergic conjunctivitis. Materials and Methods - A sing

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Katelaris, Constance H. "Topical olopatadine and loratadine compared with loratadine alone." Current Allergy and Asthma Reports 2, no. 4 (2002): 320. http://dx.doi.org/10.1007/s11882-002-0059-1.

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Manoj, Kumar Mishra, Kumari Vaidehi, and K. Singh R. "A Comparative Study of Efficacy of Topical Olopatadine (0.1%), Bepotastine (1.5%) and Alcaftadine (0.25%) in Mild to Moderate Allergic Conjunctivitis at Sri Krishna Medical College, Muzaffarpur, Bihar, India." International Journal of Pharmaceutical and Clinical Research 14, no. 8 (2022): 553–59. https://doi.org/10.5281/zenodo.13357491.

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<strong>Objectives: </strong>This study was to compare the safety and efficacy of topical Olopatadine (0.1%), Bepotastine (1.5%) and Alcaftadine (0.25%) in mild to moderate allergic conjunctivitis at Sri Krishna Medical College, Muzaffarpur, Bihar, India. <strong>Methods: </strong>All of the 150 cases were divided into three groups. Each group had 50 cases of allergic conjunctivitis. Group A: Patients were received topical 0.25% Alcaftadine eyedrops OD. Group B: Patients were received topical 0.2% Olopatadine eyedrops OD and Group C: Patients were received topical 1.5% Bepotasti

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Jagarlamudi, Anup, E. Anushree, Soma Harika, K. Kavya Sri, and Ch Rohit. "A simple randomized comparative study to evaluate the efficacy of 0.7% w/v Olopatadine hydrochloride ophthalmic solution and the Fixed Dose Combination of 0.1% w/v Olopatadine hydrochloride and 0.4% w/v Ketorolac tromethamine ophthalmic solution for the." Journal of Drug Delivery and Therapeutics 9, no. 3 (2019): 279–85. http://dx.doi.org/10.22270/jddt.v9i3.2657.

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Conjunctivitis is defined as the inflammation of the conjunctiva. Allergic conjunctivitis is an acute, intermittent or chronic inflammation of the conjunctiva due to air borne allergens. Allergic reactions occur when the immune system is hypersensitive to normally harmless environmental substances, called allergens. Allergic conjunctivitis is an increasingly prevalent allergic reaction and currently 40% of global population is suffering from allergic conjunctivitis. Being an immunopathological disease, Conjunctival mast cell degranulation plays a major role in ocular allergic disease and so tr

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Gupta, Pranav, Etti Goyal, and Jaya Devendra. "Comparative Study of 0.1% Olopatadine vs 0.05% Cyclosporine in Patients of Recalcitrant Vernal Keratoconjunctivitis." International Journal of Advanced and Integrated Medical Sciences 1, no. 4 (2016): 139–42. http://dx.doi.org/10.5005/jp-journals-10050-10048.

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ABSTRACT Introduction Vernal keratoconjunctivitis (VKC) is a chronic, recurrent, bilateral inflammatory disease showing exacerbations during the spring and summer seasons, affecting young children. Present study was conducted with the aim of comparing the efficacy of cyclosporine 0.05% with olopatadine 0.1% in recalcitrant patients of VKC. Materials and methods A prospective randomized controlled trial was performed on 40 eyes (20 patients of recalcitrant VKC) during the period of May 2015 to September 2015. A short course of mild steroid was given for 5 days to all patients as they presented

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Sujata, Kumari, Garg Gautam, Kumar Naveen, and Kumar Sunil. "A Prospective Single Centre Clinical Trial Assessing Alcaftadine (0.25%) with Olopatadine (0.2%) in Allergic Conjunctivitis." International Journal of Current Pharmaceutical Review and Research 16, no. 2 (2024): 132–36. https://doi.org/10.5281/zenodo.10976397.

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Aim: The aim of the present study was to compare the alcaftadine (0.25%) with olopatadine (0.2%) in allergicconjunctivitis.Methods: This was a prospective, observer masked, single centre clinical trial conducted in the Department ofOphthalmology for the period of one year.adhered to the principles of the declaration of Helsinki. Informedconsent was obtained from all the participants. 200 patients were enrolled in the study.Results: 100 patients received alcaftadine 0.25 % eye drop and 100 patients received olopatadine 0.2 % eye drop.Mean age of alcaftadine 0.25 % treated group was 26 ±

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Skorokhodkina, O. V., D. A. Volkova, A. V. Luntsov, M. R. Khakimova, and A. R. Valeeva. "Selecting an optimal pharmacotherapy for allergic rhinitis from the standpoint of guidelines and observation in real-life clinical practice." Meditsinskiy sovet = Medical Council, no. 7 (May 5, 2023): 80–88. http://dx.doi.org/10.21518/ms2023-058.

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Introduction. Allergic rhinitis (AR) is a common condition that has considerable impact on patients’ quality of life. Moreover, it is the risk factor for asthma development. Therefore, achieving control of AR remains crucial.Aim. To analyze comparative efficacy of fixed-dose combination of olopatadine hydrochloride – mometasone furoate versus combination of intranasal corticosteroids with second generation oral antihistamines.Materials and methods. Seventy-five patients (ages 19–59) mainly with moderate severity of AR enrolled the study. Group 1 (29 patients) was given a fixed-dose combination

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Dinesh, Sah, Kumar Pathak Satyendra, and Dayal Singh Shankar. "Efficacy and Tolerability Comparison of Olopatadine, Ketotifen, and Epinastine in Seasonal Allergic Conjunctivitis: A Prospective Open-Label Comparative Study." International Journal of Pharmaceutical and Clinical Research 14, no. 1 (2022): 110–16. https://doi.org/10.5281/zenodo.13862117.

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<strong>Background: </strong>Seasonal allergic conjunctivitis (SAC) is the most common allergic disease affecting the eye, with an estimated prevalence of 15–20%. Although sequelae affecting patients’ vision are rare, the symptoms are distressing and may have a significant socioeconomic impact, affecting the quality of life, daily activities, productivity, school performance, etc. The latest generation multiple action topical antiallergic agents such as olopatadine, ketotifen, and epinastine possess antihistaminic, mast cell stabilizing, and anti-inflammatory actions and has n

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S, Manjula, and Krishna Kumar M. "Clinicians' Perspectives on the Management of Vernal Keratoconjunctivitis (VKC) in Indian Settings." Ophthalmology Research: An International Journal 20, no. 4 (2025): 53–60. https://doi.org/10.9734/or/2025/v20i4466.

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Background: Vernal keratoconjunctivitis (VKC) is a chronic, bilateral allergic inflammation of the conjunctiva that tends to recur over time. Globally, VKC represents around 1% of all eye diseases, whereas in tropical areas, it contributes to approximately 3% of serious ophthalmic cases. Objective: The present study assesses clinicians' perspectives and preferences on the diagnosis, treatment approaches, and therapeutic strategies in the management of vernal keratoconjunctivitis (VKC) conducted in Indian settings. Methods: The cross-sectional study was conducted using a multi-response question

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Kulichenko, D. S., K. S. Pavlova, O. M. Kurbacheva, I. S. Gushchin, and N. I. Ilina. "Efficacy and safety of mometasone and olopatadine combination for nasal use in patients with allergic rhinitis caused by sensitization to epidermal allergens in continuous exposure." Russian Rhinology 33, no. 1 (2025): 48. https://doi.org/10.17116/rosrino20253301148.

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Allergy to pets is a common cause of respiratory allergic diseases. There are limited number of studies evaluating the efficacy of standard antiallergic therapy in patients with epidermal sensitization. Objective. To evaluate the efficacy and safety of using mometasone+olopatadine nasal spray in patients with allergic rhinitis (AR) caused by sensitization to epidermal allergens in continuous exposure of cause significant allergens. Patients and methods. The study involved 30 adult patients with confirmed AR caused by sensitization to epidermal allergens who had prolonged contact with pet (for

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Saurabh, Tripathi, Nidhi, and Kumar Amresh. "Comparative Study of Efficacy of Topical Olopatadine (0.1%), Bepotastine (1.5%) and Alcaftadine (0.25%) in Mild to Moderate Allergic Conjunctivitis." International Journal of Current Pharmaceutical Review and Research 15, no. 08 (2024): 363–67. https://doi.org/10.5281/zenodo.12566923.

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AbstractAim: The aim of the present study was to compare the efficacy and safety of Alcaftadine 0.25%, Olopatadinehydrochloride 0.1%, and Bepotastine besilate 1.5% ophthalmic solutions in the treatment of allergicconjunctivitis.Methods: A prospective study was conducted on 210 patients of allergic conjunctivitis visiting Department ofOphthalmology of a tertiary care hospital in south Bihar after random selection. Randomly generated treatmentregimens were sealed within opaque envelopes and were allocated to the patients after obtaining their informedconsent. A total of 210 patients were enrolle

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Schauber, J., P. Weisenseel, and T. Ruzicka. "Topical treatment of perianal eczema with tacrolimus 0·1%." British Journal of Dermatology 161, no. 6 (2009): 1384–86. http://dx.doi.org/10.1111/j.1365-2133.2009.09345.x.

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Bellew, S., and J. Q. Del Rosso. "Topical treatment of perianal eczema with tacrolimus 0·1%." Yearbook of Dermatology and Dermatologic Surgery 2011 (January 2011): 88–89. http://dx.doi.org/10.1016/j.yder.2010.12.016.

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Vorobyeva, I. V., M. A. Frolov, and Yu B. Slonimskiy. "Analysis of the Assortability of Ophthalmologists Using a Therapy as Part of Routine Medical Care for Patients with Inflammatory Eye Diseases." Ophthalmology in Russia 18, no. 3 (2021): 566–77. http://dx.doi.org/10.18008/1816-5095-2021-3-566-577.

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The problem of diagnosis and treatment of inflammatory eye diseases takes a leading place in Russia and in the world, but the most important thing is the correct choice of treatment methods. Purpose of the work: collection and analysis of data on doctors’ preferences under prescribing therapy in patients with inflammatory eye pathology in routine clinical practice. As a result, 5960 clinical cases from 47 Russian cities were analyzed. This article compiles data from October to November 2020. 151 medical researchers were taken part in the participation of the recruitment. Doctors made different

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Sudha, Selva, and Vella Pandi. "A comparative study of topical retinoids tretinoin-0.04% and adapalene - 0.1% in acne grade 1 and grade 2." IP Indian Journal of Clinical and Experimental Dermatology 7, no. 3 (2021): 217–21. http://dx.doi.org/10.18231/j.ijced.2021.041.

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Acne is a chronic, self-limiting inflammatory disease of pilosebaceous unit. It is multifactorial, of which Propioniobacterium acne and Sebum play an important role in etiopathogenesis.The aim of the study is to compare efficacy of Tretinoin and Adapalene in Acne Vulgaris and to compare the side effects of topical tretinoin and adapalene.Randomized prospective comparative clinical trial with sample size of 50 patients who are recruited from department of dermatology of MMCH&RI.Adapalene 0. 1% produced numerically greater lesion reduction than tretinoin 0. 04% for all lesion types. Thus, Ad

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Maganur, Prabhadevi C., Atiah Abdulrahman Ghawi, Ghadi DuhDuh Arishi, et al. "A Comparative Study on Pain Perception in Children, After Application of Pre-Cooled and Plain Topical Anaesthetic Gel During Local Anaesthetic Administration—A Parallel Three-Arm Randomised Control Trial." Children 12, no. 7 (2025): 863. https://doi.org/10.3390/children12070863.

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Background: Effective pain management in children is essential, particularly when administering local anaesthesia. This study was undertaken to compare pain perception in children after application of pre-cooled and plain topical anaesthetic gel during local anaesthetic administration. Methods: A randomised, single-blinded controlled trial was conducted among 51 children between the ages of 6 and 12, visiting the paediatric clinic, Jazan (REC-45/10/1070). Children were allocated into one of the following three groups using a simple randomisation having a 1:1:1 allocation ratio into Group I (n

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Bhat, Sonali, Sanjeev Handa, and Dipankar De. "A randomized comparative study of the efficacy of topical latanoprost versus topical betamethasone diproprionate lotion in the treatment of localized alopecia areata." Indian Journal of Dermatology, Venereology and Leprology 87 (February 5, 2021): 42–48. http://dx.doi.org/10.25259/ijdvl_787_19.

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Background: Topical corticosteroids are the standard therapy for the treatment of alopecia areata. Recently, topical latanoprost has been found effective in the treatment of eyelash alopecia areata. Objectives: The objective of this study was to compare the efficacy of topical latanoprost ophthalmic solution (group 1) with that of topical betamethasone diproprionate lotion (group 2) in the treatment of localized alopecia areata. Methods: This was a single-centre, randomized, two-armed, parallel-group efficacy trial. Fifty consecutive patients with localized alopecia areata were randomized in a

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Tamura, Tadafumi, Shigehiro Masaki, Kenji Ohmori, and Akira Karasawa. "Effect of Olopatadine and Other Histamine H₁ Receptor Antagonists on the Skin Inflammation Induced by Repeated Topical Application of Oxazolone in Mice." Pharmacology 75, no. 1 (2005): 45–52. http://dx.doi.org/10.1159/000086272.

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Higgins, E., and P. Collins. "Recurrent bullous erythema multiforme treated with topical tacrolimus 0·1% ointment." British Journal of Dermatology 164, no. 4 (2011): 884–86. http://dx.doi.org/10.1111/j.1365-2133.2010.10155.x.

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Lim, Joshua, Adam C. Carle, Richard M. Carpiano, and Donald L. Chi. "Topical fluoride hesitancy and opposition are significantly and positively associated: A cross-sectional study." PLOS One 20, no. 4 (2025): e0322027. https://doi.org/10.1371/journal.pone.0322027.

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The goal of this study was to evaluate the associations between topical fluoride hesitancy and opposition to determine if hesitancy is a potential precursor to opposition. We administered an 85-item survey (11/2020-09/2021) to 1,135 caregivers that included the 20-item, 5-domain Fluoride Hesitancy Identification Tool (FHIT), from which we created five domain-specific scores of topical fluoride hesitancy (none/moderate/high for each domain); a score reflecting any topical fluoride hesitancy (moderate/high on any of the five domains); and a topical fluoride hesitancy severity score (total number

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MAKRIS, UNA E., MINNA J. KOHLER, and LIANA FRAENKEL. "Adverse Effects of Topical Nonsteroidal Antiinflammatory Drugs in Older Adults with Osteoarthritis: A Systematic Literature Review." Journal of Rheumatology 37, no. 6 (2010): 1236–43. http://dx.doi.org/10.3899/jrheum.090935.

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Objective.To systematically review the literature on reported adverse effects (AE) associated with use of topical nonsteroidal antiinflammatory drugs (NSAID) in older adults with osteoarthritis (OA).Methods.A systematic search of Medline (1950 to November 2009), Scopus, Embase, Web of Science, Cochrane databases, Dissertation and American College of Rheumatology meeting abstracts was performed to identify original randomized controlled trials, case reports, observational studies, editorials, or dissertations reporting AE from topical NSAID in older adults with OA. Information was sought on stu

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Cankaya, Deniz, Uygar Dasar, Ahmet Burak Satilmis, Serdar Hakan Basaran, Mustafa Akkaya, and Murat Bozkurt. "The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty." Journal of Orthopaedic Surgery 25, no. 1 (2017): 230949901668472. http://dx.doi.org/10.1177/2309499016684725.

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Aims: The combined (IV (intravenous) + topical) use of tranexamic acid (TXA) has been shown to be a safe method and more effective than single (IV or topical) application. The optimal administration method of TXA is still being investigated and safety, efficiency and cost are the three main crucial parameters in achieving the best administration method. We aimed to determine whether combined (oral + topical) use of TXA reduced blood loss and transfusion rates more than single (topical) administration in TKA and whether oral + topical use is as safe and efficient as the IV + topical use, in add

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Zabanova, V. E., K. I. Ershov, M. S. Selyakova, et al. "Cellular composition of an experimental chemical injury to the cornea after exposure to PEGylated hyaluronidase and subtilisin enzymes." Journal of Siberian Medical Sciences 7, no. 1 (2023): 89–109. http://dx.doi.org/10.31549/2542-1174-2023-7-1-89-109.

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Introduction. Under conditions of chemical damage to the cornea, its cellular structure is significantly disrupted, requiring emergency highly differentiated regeneration without an expressed proliferative component of inflammation and expansion of immunocompetent cells to gain an antimicrobial potential. For the purpose of pharmacological initiation of these processes, the study of the topical administration of anti-inflammatory enzyme preparations, such as subtilisin and hyaluronidase, is pathogenetically justified. Aim. To study the effect of hyaluronidase and subtilisin, PEGylated (polyeth

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Ewald, Margaret M., Amy J. Rankin, Jessica M. Meekins, Geraldine Magnin, and Butch KuKanich. "Prednisolone and dexamethasone are systemically absorbed after topical application of ophthalmic suspensions in healthy dogs." American Journal of Veterinary Research 83, no. 4 (2022): 339–48. http://dx.doi.org/10.2460/ajvr.21.04.0059.

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Abstract OBJECTIVE To quantify plasma concentrations of prednisolone and dexamethasone (peripheral and jugular) and cortisol following topical ophthalmic application of 1% prednisolone acetate and 0.1% dexamethasone to healthy adult dogs. ANIMALS 12 purpose-bred Beagles. PROCEDURES Dogs received 1 drop of 1% prednisolone acetate (n = 6) or neomycin polymyxin B dexamethasone (ie, 0.1% dexamethasone; 6) ophthalmic suspension in both eyes every 6 hours for 14 days. Blood samples (peripheral and jugular) were collected on days 0, 1, 7, and 14 and analyzed for plasma prednisolone and dexamethasone

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Bae, Jae Hoon, Jang Su Lee, Nam Guk Kim, and Hyun Myung Oh. "Effect of Filmogen Topical Gel on Pain and Hemorrhage after Tonsillectomy." Korean Journal of Otorhinolaryngology-Head and Neck Surgery 63, no. 6 (2020): 265–69. http://dx.doi.org/10.3342/kjorl-hns.2019.00052.

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Background and Objectives Tonsillectomy is one of the most common operative procedures in otorhinolaryngology. Most patients following tonsillectomy suffer from postoperative pain and hemorrhage. This study was performed to investigate whether filmogen topical gel (PHARGEL<sup>Ⓡ</sup>, Vitrobio SAS), applied to the tonsillectomy site after tonsillectomy reduced pain and hemorrhage.Subjects and Method A total of 40 patients over 15 years old scheduled for elective tonsillectomy were randomly divided into two groups. After tonsillectomy and postoperative day 0, 1, 2, and 7, one group

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Ahluwalia, A., R. W. Mohamed, and R. J. Flower. "Induction of lipocortin 1 by topical steroid in rat skin." Biochemical Pharmacology 48, no. 8 (1994): 1647–54. http://dx.doi.org/10.1016/0006-2952(94)90210-0.

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Munir, Ali Arslan, Sumbal Rana, Saquib Naeem, Muhammad Shahid, Aftab Hussain, and Shafqat Hussain. "Comparison of Topical Anesthesia, Intracameral 1% Lignocaine and Topical Anesthesia and Intravenous Acetaminophen and Topical Anesthesia for Phacoemulsification in Cataract Surgery." Pakistan Armed Forces Medical Journal 73, SUPPL-2 (2023): S360–64. http://dx.doi.org/10.51253/pafmj.v73isuppl-2.10086.

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Objective: To compare the effectiveness of topical Proparacaine 0.5%, topical Proparacaine 0.5% and topical Proparacaine 0.5% for intraoperative analgesia and surgeon’s score undergoing simple cataract surgery. Study Design: Quasi-experimental study. Place and Duration of Study: Department of Anaesthesia, Armed Forces Institute of Ophthalmology, Rawalpindi Pakistan,from Sep 2022 to Mar 2023. Methodology: Sixty patients aged 40 years and more, ASA-l and ll, undergoing elective simple cataract surgeries were observed by taking 20 patients in all three groups (n=20). Group-T: Topical Anesthesia g

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Pomerantz, H., and M. A. Weinstock. "Predictors of local adverse effects caused by topical tretinoin cream 0·1% in the Veterans Affairs Topical Tretinoin Chemoprevention trial." British Journal of Dermatology 171, no. 3 (2014): 642–45. http://dx.doi.org/10.1111/bjd.12987.

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Hazra, Moumita. "A rational pharmacotherapeutic study of comparative safety among topical anti-acne 1% nadifloxacin monotherapy, 0.1% adapalene monotherapy, 0.025% tretinoin monotherapy, 1% nadifloxacin and 0.1% adapalene combination therapy and 1% nadifloxacin and 0.025% tretinoin combination therapy, in mild to moderate acne vulgaris, in tertiary care hospitals." International Journal of Basic & Clinical Pharmacology 8, no. 9 (2019): 1959. http://dx.doi.org/10.18203/2319-2003.ijbcp20193662.

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Background: Topical adapalene and tretinoin, are comedolytic, anti-comedogenic and anti-inflammatory, on RAR (α, β, γ) receptors binding. Adapalene enables quicker follicular penetration, by lesser anti-AP-1 (c-Jun, c-Fos) and no CRBPII mRNA actions, causing chemical stability, lipophilicity and less photo-lability, producing lesser photosensitivity and no skin irritation, unlike tretinoin; wherein reducible by overnight application and combination therapy, slow-release polymers or emollients, respectively. Topical nadifloxacin is bactericidal, anti-inflammatory and comedolytic, with inhibitor

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Seshathri, E., and R. Deepthi Krishna. "Comparison of efficacy and safety of topical luliconazole with topical fluconazole against tinea corporis in a tertiary care hospital." International Journal of Basic & Clinical Pharmacology 10, no. 7 (2021): 840. http://dx.doi.org/10.18203/2319-2003.ijbcp20212383.

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Background: Dermatophytosis is a common cutaneous infection worldwide with prevalence varying from 20% to 25%. Luliconazole is a newer topical antifungal applied once daily with greater reservoir property in stratum corneum. Objective of the study was to compare the clinical efficacy and safety of luliconazole 1% cream with Fluconazole 1% cream in patients with mild to severe grades of tinea corporis.Methods: A total of 100 patients with mycologically confirmed tinea corporis were randomised into group A and B respectively. Group A, 50 patients received luliconazole 1% for 2 weeks and group B,

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Philipp, Sandra. "Atopische Dermatitis: IL-13-Antikörper macht Hoffnung auf gut verträgliche und lang wirkende Therapieoption." Kompass Dermatologie 9, no. 3 (2021): 138–39. http://dx.doi.org/10.1159/000518035.

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<b>Background:</b> Tralokinumab, a fully human monoclonal antibody, specifically neutralizes interleukin-13, a key cytokine driving peripheral inflammation in atopic dermatitis (AD). In phase II studies, tralokinumab combined with topical corticosteroids provided early and sustained improvements in AD signs and symptoms. <b>Objectives:</b> To evaluate the efficacy and safety of tralokinumab monotherapy in adults with moderate-to-severe AD who had an inadequate response to topical treatments. <b>Methods:</b> In two 52-week, randomized, double-blind, placebo-c

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Gocmen, Julide Sedef, Unase Buyukkocak, and Osman Caglayan. "In vitro antibacterial activity of some systemic and topical antihistaminic preparations." Clinical & Investigative Medicine 32, no. 6 (2009): 232. http://dx.doi.org/10.25011/cim.v32i6.10657.

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Purpose: In vitro antibacterial activity of topical and systemic antihistaminic preparations containing different active substrates against the standard strains of two bacteria was evaluated. Methods: Four topical and 3 systemic preparations containing pheniramine maleate, chlorophenoxamine hydrochloride, and diphenhydramine hydrochloride were studied. The antibacterial activities of these preparations against strains of S. aureus (American Type Culture Collection, ATCC 29213) and S. epidermidis (ATCC 25212) were tested using the disc diffusion method. In addition, the Minimal Innhibitory Conc

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Crasta, Manuela, Kevin Arteaga, Teresa a, and Marta Leiva. "Topical 1% cyclosporine eyedrops for the treatment of crystalline corneal dystrophy in dogs." Open Veterinary Journal 13, no. 9 (2023): 1167. http://dx.doi.org/10.5455/ovj.2023.v13.i9.12.

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Background: Crystalline corneal dystrophy (CCD) is the most common type of corneal lipidic deposition in dogs. CCD is a primary metabolic disorder of the corneal fibroblast featuring an accumulation of extracellular and intracellular lipid deposits. Corneal lipid deposits create a corneal opacity and modify the interfibrillar collagen distance, inducing light scattering. Corneal vascularization is not usually associated with the disease, but, in case of chronicity, cell death may produce inflammation and new corneal vessels are developed. To the best of the authors’ knowledge, this is the firs

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Ellis, Millikan, Smith, et al. "Comparison of adapalene 0·1% solution and tretinoin 0·025% gel in the topical treatment of acne vulgaris." British Journal of Dermatology 139, s52 (1998): 41–47. http://dx.doi.org/10.1046/j.1365-2133.1998.1390s2041.x.

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Rongioletti, F., E. Zaccaria, and G. Viglizzo. "Failure of topical 0·1% alitretinoin gel for classic Kaposi sarcoma: first European experience." British Journal of Dermatology 155, no. 4 (2006): 856–57. http://dx.doi.org/10.1111/j.1365-2133.2006.07392.x.

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Chovatiya, Raj, Aseel Bin Sawad, Janine Fournier, et al. "Efficacy Outcomes in Clinical Trials of Atopic Dermatitis Treatments: A Systematic Literature Review." SKIN The Journal of Cutaneous Medicine 8, no. 2 (2024): s381. http://dx.doi.org/10.25251/skin.8.supp.381.

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Introduction: Complete skin clearance is a key atopic dermatitis (AD) treatment goal. Treatment efficacy in AD trials is evaluated using a range of clinical measures with the Investigator’s Global Assessment (IGA) as a key endpoint. Multiple and varied forms of the IGA scale are utilized across trials, including the Investigator’s Static Global Assessment and the Validated Investigator Global Assessment for ADTM. IGA scores usually range from 0 (clear) to 1 (almost clear), 2 (mild), 3 (moderate), and 4 (severe), but contain differences in detail assessed. Efficacy endpoints using IGA scales in

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Poonai, Naveen, Karina Burke, Shaily Brahmbhatt, et al. "35 Implementation of a quality improvement initiative to reduce pain and anxiety associated with needle-related procedures in a Canadian paediatric emergency department." Paediatrics & Child Health 26, Supplement_1 (2021): e26-e27. http://dx.doi.org/10.1093/pch/pxab061.028.

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Abstract Primary Subject area Emergency Medicine - Paediatric Background Needle-related procedures such as intravenous (IV) insertion, venipuncture, and lumbar puncture (LP) are commonly performed in children, particularly in the emergency department (ED). Children consistently rate these needle-related procedures as very distressing. While topical anesthetics have been shown to be highly effective and are available, they are inconsistently used. The Children’s Comfort Promise was originally developed at the Minnesota Children’s Hospital. It requires nursing staff to use four strategies for ch

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Academic, Journal of Medical Sciences. "Clinical Evaluation and Outcomes of Topical versus Retrobulbar Anesthesia in Cataract surgery by Phacoemelsification." Academic Journal of Medical Sciences 10, no. 3 (2024): 54–68. https://doi.org/10.5281/zenodo.12785555.

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<strong>Summary</strong>: <em>The objective of this study is to assess and compare the degrees of pain and problems experienced by patients undergoing phacoemulsification and implantation of foldable intraocular lenses. The study will specifically focus on patients with senile cataract who receive either topical or retrobulbar anaesthesia. An experimental study was conducted over a 10-month period at Al-Basir Ophthalmic Centre in Hawler, Iraq, using random assignment and control groups. We examined the eyes of 200 patients, totaling 200 in number. Phacoemulsification was performed on 100 eyes

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Silla, Aimee J., Michael McFadden, and Phillip G. Byrne. "Hormone-induced spawning of the critically endangered northern corroboree frog Pseudophryne pengilleyi." Reproduction, Fertility and Development 30, no. 10 (2018): 1352. http://dx.doi.org/10.1071/rd18011.

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Fundamental knowledge of the optimal hormone concentrations required to stimulate amplexus and spawning in breeding pairs of amphibians is currently lacking, hindering our understanding of the proximate mechanisms underpinning mating behaviour. The present study investigated the effects of: (1) the dose of a gonadotropin-releasing hormone analogue (GnRH-a) administered; (2) male–female hormone administration interval; and (3) topical application of GnRH-a, on spawning success in the northern corroboree frog. Administration of GnRH-a at doses of 0.5, 1.0 and 2.0 μg g−1 were highly successful, w

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Shrestha, David, and Anup Shrestha. "Physiological Phimosis and The Use of Topical Steroid." Medical Journal of Pokhara Academy of Health Sciences 3, no. 1 (2020): 221–24. http://dx.doi.org/10.3126/mjpahs.v3i1.31915.

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Background: Aim of this study is to see the efficiency of topical 1% hydrocortisone in the treatment of physiological phimosis. Materials and Methods: Retrospective study was conducted in the Kaski Model Hospital, Pokhara, Gandaki, Nepal from January 2016 to June 2019. Forty-nine patients treated in outpatient basis have been selected for this study. Selection was made according to Kikiros and Woodward retractability grading. Results: Out of 49(100%) patients 40(81.63%) achieved complete response to steroid, which is Kikiros and Woodward retractability grade 0. 2(4.08%) patients sh

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Chaudhary, Muhammad Ajmal, Muhammad Saad Ullah, Muhammad Younis Tahir, Razaullah Khan, and Sajjad Muhammad Haider. "The Safety and Effectiveness of 0.03% Tacrolimus in Pediatric Patients Presenting with Vernal Keratoconjunctivitis in Children Hospital, Multan." Life and Science 6, no. 1 (2025): 06. https://doi.org/10.37185/lns.1.1.650.

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Objective: This study evaluated the safety and effectiveness of tacrolimus (0.03%) ointment in treating pediatric patients with vernal keratoconjunctivitis.Study Design: A prospective, interventional study.Place and Duration of Study: The study was conducted at the Department of Pediatrics, The Children's Hospital and The Institute of Child Health Multan, Pakistan over one year from February 2021 to February 2022.Methods: The research involved sixty pediatric patients who had bilateral vernal keratoconjunctivitis. Patients in the tacrolimus cohort were treated with 0.03 percent tacrolimus oint

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Markinson, Bryan, and Bryan Caldwell. "Efinaconazole Topical Solution, 10%." Journal of the American Podiatric Medical Association 105, no. 5 (2015): 407–11. http://dx.doi.org/10.7547/14-088.

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Background We sought to evaluate the efficacy of efinaconazole topical solution, 10%, in patients with onychomycosis and coexisting tinea pedis. Methods We analyzed 1,655 patients, aged 18 to 70 years, randomized (3:1) to receive efinaconazole topical solution, 10%, or vehicle from two identical multicenter, double-blind, vehicle-controlled 48-week studies evaluating safety and efficacy. The primary end point was complete cure rate (0% clinical involvement of the target toenail and negative potassium hydroxide examination and fungal culture findings) at week 52. Three groups were compared: pat

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Sundstrup, Emil, Markus D. Jakobsen, Mikkel Brandt, et al. "Acute Effect of Topical Menthol on Chronic Pain in Slaughterhouse Workers with Carpal Tunnel Syndrome: Triple-Blind, Randomized Placebo-Controlled Trial." Rehabilitation Research and Practice 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/310913.

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Topical menthol gels are classified “topical analgesics” and are claimed to relieve minor aches and pains of the musculoskeletal system. In this study we investigate the acute effect of topical menthol on carpal tunnel syndrome (CTS). We screened 645 slaughterhouse workers and recruited 10 participants with CTS and chronic pain of the arm/hand who were randomly distributed into two groups to receive topical menthol (Biofreeze) or placebo (gel with a menthol scent) during the working day and 48 hours later the other treatment (crossover design). Participants rated arm/hand pain intensity during

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Gniadecki, R. "A vitamin D analogue KH 1060 activates the protein kinase C– c-fos signalling pathway to stimulate epidermal proliferation in murine skin." Journal of Endocrinology 143, no. 3 (1994): 521–25. http://dx.doi.org/10.1677/joe.0.1430521.

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Abstract The cellular signalling pathways of a potent 20-epi-22-oxa vitamin D3 analogue (KH 1060) were examined in vivo in a hairless mouse model. Seventy two hours after a single topical application of KH 1060 a thickening of the epidermis (from 24·8 ±1·2 μm at 0·01 pmol/cm2 KH 1060 to 124·2 ± 6 μm at 5 pmol/cm2 KH 1060, P<0·001) was elicited due to epidermal hyperproliferation. This effect could be blocked by topical 2·5 μmol/cm sphingosine, an inhibitor of protein kinase C. Two hours after topical application of 2·5 pmol/cm2 KH 1060 a translocation of protein kinase C activity from cytop

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Jeroudi, Abdallah M., Wen-Shi Shieh, Yicheng Chen, Daniel B. Connors, Kevin J. Blinder, and Gaurav K. Shah. "Topical Anesthesia in 27-Gauge Pars Plana Vitrectomy." Journal of VitreoRetinal Diseases 2, no. 2 (2018): 100–103. http://dx.doi.org/10.1177/2474126418762228.

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Purpose: To explore the safety, comfort, and feasibility of topical anesthesia in 27-gauge pars plana vitrectomy surgery. Methods: A prospective, observational case series of 37 nonconsecutive patients undergoing 3-port, 27-gauge pars plana vitrectomy under topical anesthesia with lid block from July 2016 to March 2017 with a single surgeon was performed. Topical anesthesia was achieved with proparacaine 0.5% drops and 2% lidocaine gel. Surgery was performed for select indications with carefully selected patients amenable to topical anesthesia. Patients were queried and observed to identify th

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Mutlu, Tansel, Mehmet Arıcan, Zekeriya Okan Karaduman, et al. "Effect of Oral + Topical and Only Topical Tranaxamic Acid Application on Blood Loss and Postoperative Transfusion in Primary Total Hip Arthroplasty." Journal of Clinical Medicine 14, no. 4 (2025): 1275. https://doi.org/10.3390/jcm14041275.

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Objectives: Total hip arthroplasty is one of the most common procedures performed to reduce pain and improve hip functions in patients with advanced hip osteoarthritis, but perioperative blood loss, acute anemia and transfusion requirement increase the risk of morbidity and mortality during and after surgery and negatively affect functional recovery. We aimed to present the comparative results of oral + topical and only topical tranexamic acid application to reduce blood loss and postoperative transfusion in primary total hip arthroplasty. Methods: We retrospectively evaluated the patients who

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Celiker, Hande, Levent Karabas, and Ozlem Sahin. "A Comparison of Topical or Retrobulbar Anesthesia for 23-Gauge Posterior Vitrectomy." Journal of Ophthalmology 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/237028.

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Background. To compare the efficacy and safety of topical anesthesia versus retrobulbar anesthesia in 23-gauge vitreoretinal surgery.Materials and Methods. A total of 63 patients scheduled for 23 G posterior vitrectomy without scleral buckling procedures were included in the study. The patients were randomly assigned to receive either topical (Group 1,n=31) or retrobulbar anesthesia (Group 2,n=32). Postoperatively, patients were shown a visual analogue pain scale (VAPS) from 1 (no pain or discomfort) to 4 (severe pain or discomfort) to rate the levels of pain.Results. There was more discomfort

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