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Journal articles on the topic 'Toronto Harbour'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Desfor, Gene. "Planning Urban Waterfront Industrial Districts." Articles 17, no. 2 (2013): 77–91. http://dx.doi.org/10.7202/1017653ar.

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The process by which one particular section of Toronto's waterfront, Ashbridge's Bay, was developed during the 1889-1910 period is analysed in the context of broader industrialization and urban reform movements. Primary sources, largely from the Toronto Harbour Commissioners' Archives recently opened to the public, and the City of Toronto Archives, provide the basis for the analysis. Evidence demonstrates that Toronto's influential 1912 waterfront plan, crucial in reshaping the lakefront, was built on numerous previous schemes for improving the port, the harbour, and adjacent areas. Ownership

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2

Moir, Michael. "The Toronto Harbour Commission Archives." Urban History Review 17, no. 2 (1988): 112. http://dx.doi.org/10.7202/1017657ar.

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3

Hlevca, Bogdan, Matthew G. Wells, Liset Cruz Font, et al. "Water circulation in Toronto Harbour." Aquatic Ecosystem Health & Management 21, no. 3 (2018): 234–44. http://dx.doi.org/10.1080/14634988.2018.1500059.

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4

Bogdan, Hlevca, G. Wells Mathew, Cruz Font Liset, et al. "Water circulation in Toronto Harbour." Aquatic Ecosystem Health and Management 21, no. 3 (2018): 233–44. https://doi.org/10.1080/14634988.2018.1500059.

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We present an overview of physical processes that drive water circulation within the extended system of coastal embayments in the Toronto Harbour. The different water circulation patterns occur at various spatial and temporal scales, and our paper provides context for the various efforts to improve water quality by the Toronto and Region Remedial Action Plan. Velocity profiles and water level measurements showed that the harbour’s Helmholtz pumping mode drives a 1- hour period oscillation, which can influence flushing of the shallow embayments. This process likely persists year-round and

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5

Merrens, Roy. "Port Authorities as Urban Land Developers." Articles 17, no. 2 (2013): 92–105. http://dx.doi.org/10.7202/1017654ar.

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Port authorities have been important presences in Canada's port cities, playing major roles in determining the physical form and land-use functions of urban waterfront lands. Their formative roles warrant attention from scholars concerned with the city-building process in Canada. This study focuses upon one such body, The Toronto Harbour Commissioners, and how and why it has functioned as a land development agency. An analysis of the commissions Outer Harbour project between 1912 and 1968 shows the commissions central concern with land development: ostensibly presented as a harbour facility, t

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6

Desfor, Gene. "Restructuring the Toronto Harbour Commission: land politics on the Toronto waterfront." Journal of Transport Geography 1, no. 3 (1993): 167–81. http://dx.doi.org/10.1016/0966-6923(93)90020-z.

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7

Bartlett, Adrienne J., Uwe Borgmann, D. George Dixon, Suzanne P. Batchelor, and R. James Maguire. "Toxicity and bioaccumulation of tributyltin in Hyalella azteca from freshwater harbour sediments in the Great Lakes Basin, Canada." Canadian Journal of Fisheries and Aquatic Sciences 62, no. 6 (2005): 1243–53. http://dx.doi.org/10.1139/f05-035.

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This study was designed to evaluate the risk that tributyltin (TBT) levels in harbour sediments pose to the freshwater invertebrate Hyalella azteca and to rank TBT as an environmental concern compared with inorganic metal species. Four-week toxicity tests and 2-week bioaccumulation tests were conducted with sediments collected from five harbours historically contaminated with TBT: Montreal, Kingston, Toronto, Hamilton, and Port Weller. While there was no observable effect of TBT on survival or growth of H. azteca, bioaccumulation of TBT exceeded levels expected to cause chronic toxicity in som

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8

Richardson, Teri L., and Leo Ehrenreich. "SITE Demonstration of the Toronto Harbour Commissioners Soil Recycling Project." Air & Waste 44, no. 5 (1994): 727–31. http://dx.doi.org/10.1080/1073161x.1994.10467276.

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9

Halfon, Efraim, and Don Poulton. "Distribution of Chlorobenzenes, Pesticides and PCB Congeners in Lake Ontario Near the Toronto Waterfront." Water Quality Research Journal 27, no. 4 (1992): 751–72. http://dx.doi.org/10.2166/wqrj.1992.046.

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Abstract Concentrations of 89 toxic organic pollutants (25 contaminants, including chlorobenzenes and pesticides, and 64 PCB isomers) were measured in Lake Ontario along the Toronto Waterfront area during the spring, summer and fall of 1987. Data indicate that Humber Bay, the inner harbour, and the areas near the Toronto Main Sewage Treatment Plant (STP) are the most polluted. While contaminant levels in some offshore areas are high, average levels for most contaminants are similar to whole-lake levels. Lake Ontario receives large amounts of pollutants from atmospheric sources and the Niagara

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10

Benn, Carl. "Toronto Harbour and the Defence of the Great Lakes Region, 1783-1870." Northern Mariner / Le marin du nord 4, no. 1 (1994): 1–15. http://dx.doi.org/10.25071/2561-5467.745.

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11

Veilleux, M. A. N., J. D. Midwood, C. M. Boston, et al. "Assessing occupancy of freshwater fishes in urban boat slips of Toronto Harbour." Aquatic Ecosystem Health & Management 21, no. 3 (2018): 331–41. http://dx.doi.org/10.1080/14634988.2018.1507530.

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12

Amos, Janet. "Rural Roots: A Theatre Memoir." Canadian Theatre Review 84 (September 1995): 9–13. http://dx.doi.org/10.3138/ctr.84.002.

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The theatre has always been a part of my life. I had my first drama lessons with Dora Mavor Moore at the New Play Society in Toronto. As a kid, I saw Toby Robins play Peter Pan at the Eaton Auditorium. My mother, the actress Beth Amos, took me to the Royal Alexandra Theatre in Toronto to see The King and I with Gertrude Lawrence and Yul Brynner. I found the music annoying because it interrupted the story. I remember sitting at the back of Prudhomme’s Theatre in Vineland (near St Catharines) when I was about nine watching my mother in a matinee of For Love or Money. But I was never stage-struck

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13

Bowen, K. L., and W. J. S. Currie. "Effect of the urbanized embayment Toronto Harbour on the composition and production of zooplankton." Journal of Great Lakes Research 47, no. 2 (2021): 378–94. http://dx.doi.org/10.1016/j.jglr.2021.01.015.

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14

Munawar, M., M. Fitzpatrick, H. Niblock, and J. Lorimer. "Autotrophic and heterotrophic indicators of ecological impairment in Toronto Harbour and coastal Lake Ontario." Aquatic Ecosystem Health & Management 21, no. 3 (2018): 293–305. http://dx.doi.org/10.1080/14634988.2018.1508935.

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15

Munawar, M., W. P. Norwood, L. H. McCarthy, and C. I. Mayfield. "In situ bioassessment of dredging and disposal activities in a contaminated ecosystem: Toronto Harbour." Hydrobiologia 188-189, no. 1 (1989): 601–18. http://dx.doi.org/10.1007/bf00027829.

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16

Gurtner-Zimmermann, Arnold. "Analysis of Lower Green Bay and Fox River, Collingwood Harbour, Spanish Harbour, and the Metro Toronto and Region remedial action plan (RAP) processes." Environmental Management 20, no. 4 (1996): 449–59. http://dx.doi.org/10.1007/bf01474648.

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17

Peat, Tyler B., Lee F. G. Gutowsky, Susan E. Doka, et al. "Comparative thermal biology and depth distribution of largemouth bass (Micropterus salmoides) and northern pike (Esox lucius) in an urban harbour of the Laurentian Great Lakes." Canadian Journal of Zoology 94, no. 11 (2016): 767–76. http://dx.doi.org/10.1139/cjz-2016-0053.

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Understanding how individuals are distributed in space and time, as well as how they interact with dynamic environmental conditions, represent fundamental knowledge gaps for many fish species. Using acoustic telemetry tags, we monitored the temperatures and depths used by northern pike (Esox lucius L., 1758) and largemouth bass (Micropterus salmoides (Lacepède, 1802)) in Toronto Harbour (Lake Ontario). Northern pike and largemouth bass had similar thermal experiences throughout the year, except during summer, when northern pike were observed in cooler waters than largemouth bass. Both species

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18

McIlwraith, Thomas. "Digging Out and Filling In." Articles 20, no. 1 (2013): 15–33. http://dx.doi.org/10.7202/1017560ar.

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A half-million square metres (50 hectares) was brought in to railroad and commercial use at wharfage-level along the Toronto lakefront during the 1850s. This major engineering project involved cutting down the terrace south of Front Street, and this was the source of most of the fill dumped into the Bay. Neither railroad cars nor harbour dredges were capable of delivering the additional material necessary for building anticipated port lands, and many parts of the waterfront remained improperly filled for decades. The land-area that was created should be regarded as a byproduct of short-run, se

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19

SCHMIDT, J., P. SETO, and D. Averill. "Pilot-Scale Study of Satellite Treatment Options for the Control of Combined Sewer Overflows." Water Quality Research Journal 32, no. 1 (1997): 169–84. http://dx.doi.org/10.2166/wqrj.1997.012.

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Abstract Combined sewer overflows (CSOs) have been recognized for many years as a pollution problem within the Great Lakes ecosystem. CSOs were identified as a source of contamination in 10 of the 17 Canadian “Areas of Concern” designated by the International Joint Commission, and were considered a major problem in Hamilton Harbour and the Metropolitan Toronto Waterfront. Satellite treatment systems (located upstream in the sewerage system) were identified as being significantly more cost effective than other CSO control options in a feasibility study conducted for Metropolitan Toronto. Conseq

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20

Hoyle, James A., Christine M. Boston, Cindy Chu, Michael J. Yuille, Rick Portiss, and Robert G. Randall. "Fish community indices of ecosystem health: How does Toronto Harbour compare to other Lake Ontario nearshore areas?" Aquatic Ecosystem Health & Management 21, no. 3 (2018): 306–17. http://dx.doi.org/10.1080/14634988.2018.1502562.

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21

Stortz, Paul. "“Rescue Our Family From a Living Death:” Refugee Professors and the Canadian Society for the Protection of Science and Learning at the University of Toronto, 1935-19461." Journal of the Canadian Historical Association 14, no. 1 (2005): 231–61. http://dx.doi.org/10.7202/010326ar.

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Abstract Throughout the 1930s into the early 1940s, the University of Toronto was inundated with desperate letters for succor from European professors who were persecuted under Nazism. Many of the stories in these appeals outlined life and death situations. The university responded by hiring some of these professors, but vigorous debate erupted with the establishment of the Canadian Society for the Protection of Science of Learning in 1939. The Toronto Society, the most influential of the other, more smaller Societies in Canada, was struck as an organization to place refugee professors in Cana

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22

Scott, John D., and Lance A. Durden. "Songbird-transported tick Ixodes minor (Ixodida: Ixodidae) discovered in Canada." Canadian Entomologist 147, no. 1 (2014): 46–50. http://dx.doi.org/10.4039/tce.2014.34.

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AbstractTicks are carried into Canada by millions of birds during spring migration, and some of these blood-sucking ectoparasites harbour tick-associated pathogens. During a pan-Canadian study of ticks on avian hosts, we identified an extralimital tick, Ixodes minor Neumann (Ixodida: Ixodidae) collected from a Common Yellowthroat, Geothlypis trichas (Linnaeus) (Passeriformes: Parulidae) at Toronto, Ontario, Canada. Although the I. minor larva was not tested for any tick-borne pathogens, this tick species is considered a competent enzootic vector of the Lyme disease spirochete, Borrelia burgdor

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23

Michaux, Johan, Markus Dyck, Peter Boag, Stephen Lougheed, and Peter Van Coeverden de Groot. "New Insights on Polar Bear (Ursus maritimus) Diet from Faeces based on Next-Generation Sequencing Technologies." ARCTIC 74, no. 1 (2021): 87–99. http://dx.doi.org/10.14430/arctic72239.

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Practical tools to quantify range-wide dietary choices of the polar bear have not been well developed, thus impeding the monitoring of this species in a changing climate. Here we describe our steps toward non-invasive polar bear diet determination with the optimization of 454 pyrosequencing of a 136 base pair (bp) mitochondrial cytochrome b (cytb) fragment amplified from the extracts of captive and wild polar bear faeces. We first determine the efficacy, reliability, and accuracy of our method using five faecal samples from a captive polar bear fed a known diet at the Canadian Polar Bear Habit

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24

Sherlock, Cassandra, Rafaela F. Gutierrez, Michael David, and Chelsea M. Rochman. "A methodology for quantifying and characterizing litter from trash capture devices (TCDs) to measure impact and inform upstream solutions." FACETS 8 (January 1, 2023): 1–12. http://dx.doi.org/10.1139/facets-2022-0034.

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Trash capture devices (TCDs) are a rapidly evolving tool for municipal governments, non-governmental organizations, and industries to divert litter from our waterways. Here, we introduce protocols to initiate trash trapping projects to quantify and characterize captured anthropogenic litter based on a case study using Seabins. In addition, we have introduced a network for global data collection via TCDs. Our first protocol is a visual audit of the potential site to inform the type and location for TCD deployment. Our next two protocols quantify and characterize the litter captured by TCDs: (1)

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25

Allen, C. Michael, Donald Duchesne, and Jagmohan Humar. "Application of computer-aided design in the Ontario Domed Stadium project." Canadian Journal of Civil Engineering 15, no. 1 (1988): 14–23. http://dx.doi.org/10.1139/l88-002.

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Application of computer-aided design (CAD) in civil engineering is most effective when the entire design process, from design and analysis to construction, is integrated. Owing to the complexity of civil engineering projects, complete integration of design has not been achieved as yet. However, even partial integration considerably improves the reliability and efficiency of the design process. This is illustrated in the paper through a case study on the application of CAD in the structural design of the Ontario Domed Stadium. The Ontario Domed Stadium, currently being constructed on a site nea

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26

Das, Anirban, Vienna Mazzoli, Nicholas Fernandez, et al. "IMMU-13. TRANS-SPECIES STUDY OF IDH-MUTANT REPLICATION-REPAIR DEFICIENT HIGH-GRADE GLIOMAS (RRD-HGG) AND RESPONSE TO COMBINED TARGETED AND IMMUNOTHERAPY: AN IRRDC STUDY." Neuro-Oncology 26, Supplement_8 (2024): viii154. http://dx.doi.org/10.1093/neuonc/noae165.0606.

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Abstract BACKGROUND AND AIMS IDH-mutant gliomas comprise &lt;10% of HGG in children. RRD-HGG comprise 5-10% of childhood HGG, demonstrate high mutation burden (TMB) and respond to immune-checkpoint inhibition (ICI). The impact of RRD within childhood IDH-mutant gliomas, and effective therapeutic options for these patients are not well-established. METHODS Clinical and multi-omic analyses were performed on IDH mut -RRD-HGG registered to the IRRDC and the Toronto glioma taskforce. Tumor development and genomic data were studied from a novel IDH mut -RRD-HGG immunocompetent mouse model. Outco

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27

McDonald, Jackson A., Danielle Boyd, Sarah Diepstraten, et al. "Abstract A043: Identifying critical vulnerabilities that sensitise Lkb1-mutant lung adenocarcinoma to T cell mediated killing." Cancer Immunology Research 11, no. 12_Supplement (2023): A043. http://dx.doi.org/10.1158/2326-6074.tumimm23-a043.

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Abstract KRAS is the most frequently altered oncogene in lung adenocarcinoma (LUAD). While the clinical development of targeted therapies has improved the treatment of a subset of patients, the heterogeneity of KRAS mutant LUAD remains a clinical challenge. Identifying tumor intrinsic dependencies through common co-occurring mutations are one approach to more effectively target KRAS-mutant LUAD. Loss-of-function mutations in STK11/Lkb1, are frequently found co-mutated with KRAS, and comprise an aggressive form of the disease. Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis, w

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28

Cheung, Alison M., Dan Wang, Kela Liu, et al. "Abstract 5622: Integrative cross-platform characterisation of mammographic screen-detected breast cancer." Cancer Research 83, no. 7_Supplement (2023): 5622. http://dx.doi.org/10.1158/1538-7445.am2023-5622.

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Abstract Mammography screening is widely used for earlier detection of breast cancer and has been shown to contribute to reduction of mortality and morbidity. Most screen-detected breast cancers are early stage, hormonal receptor-positive, HER2-negative (HR+ HER2-) breast cancers. The majority of HR+ HER2- cancers are assigned to molecular intrinsic subtypes of Luminal A and Luminal B, which generally harbour low recurrence risk, with Luminal B cases being more invasive but still less aggressive than HER2-enriched or Basal-like subtypes. However, some of these Luminal cancers later recur (5+ y

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29

Sidnell, Michael. "What’s New about Newhouse? / 3: Ambivalences of Representation." Canadian Theatre Review 61 (December 1989): 43–44. http://dx.doi.org/10.3138/ctr.61.010.

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With some deliberation, if not deep consideration, Richard Rose and D.D. Kugler have situated Newhouse right in the middle of the muddle: the muddle of political and social cliches, rough-hewn aesthetics and unarticulated expectations that pass current as criticism of the theatre. They have compounded the problems, moreover, by not making entirely clear to the theatre community what kind of ambitions and sympathies the work harbours. Hence the mute disapproval that Newhouse has been accorded and its peculiar distinction in the annual theatrical caucus race of most unnominated play of the Toron

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30

Assel, R. A., D. M. Robertson, M. H. Hoff, and J. H. Selgeby. "Climatic-change implications from long-term (1823-1994) ice records for the Laurentian Great Lakes." Annals of Glaciology 21 (1995): 383–86. http://dx.doi.org/10.3189/s0260305500016104.

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Long-term ice records (1823-1994) from six sites in different parts of the Laurentian Great Lakes region were used to show the type and general timing of climatic changes throughout the region. The general timing of both freeze-up and ice loss varies and is driven by local air temperatures, adjacent water bodies and mixing, and site morphometry. Grand Traverse Bay and Buffalo Harbor represent deeper-water environments affected by mixing of off-shore waters; Chequamegon Bay, Menominee, Lake Mendota, and Toronto Harbor represent relatively shallow-water, protected environments. Freeze-up dates g

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31

Assel, R. A., D. M. Robertson, M. H. Hoff, and J. H. Selgeby. "Climatic-change implications from long-term (1823-1994) ice records for the Laurentian Great Lakes." Annals of Glaciology 21 (1995): 383–86. http://dx.doi.org/10.1017/s0260305500016104.

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Long-term ice records (1823-1994) from six sites in different parts of the Laurentian Great Lakes region were used to show the type and general timing of climatic changes throughout the region. The general timing of both freeze-up and ice loss varies and is driven by local air temperatures, adjacent water bodies and mixing, and site morphometry. Grand Traverse Bay and Buffalo Harbor represent deeper-water environments affected by mixing of off-shore waters; Chequamegon Bay, Menominee, Lake Mendota, and Toronto Harbor represent relatively shallow-water, protected environments. Freeze-up dates g

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32

Maguire, R. James, and Richard J. Tkacz. "Degradation of the tri-n-butyltin species in water and sediment from Toronto Harbor." Journal of Agricultural and Food Chemistry 33, no. 5 (1985): 947–53. http://dx.doi.org/10.1021/jf00065a043.

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33

Jardine, Claire M., Nicol Janecko, Mike Allan, et al. "Antimicrobial Resistance in Escherichia coli Isolates from Raccoons (Procyon lotor) in Southern Ontario, Canada." Applied and Environmental Microbiology 78, no. 11 (2012): 3873–79. http://dx.doi.org/10.1128/aem.00705-12.

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ABSTRACTWe conducted a cross-sectional study to determine the prevalence of antimicrobial resistance (AMR) in fecalEscherichia coliisolates from raccoons (Procyon lotor) living in Ontario, Canada. From June to October 2007, we trapped raccoons in three areas: one primarily urban site around Niagara, one primarily rural site north of Guelph, and one at the Toronto Zoo. In addition, we conducted a longitudinal study at the Toronto Zoo site to investigate the temporal dynamics of fecalE. coliand AMR in raccoons. Reduced susceptibility to ≥1 antimicrobial agent was detected inE. coliisolates from

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34

Wilson, Hanneke. "antonina harbus and russell poole (edd.). Verbal Encounters: Anglo-Saxon and Old Norse Studies for Roberta Frank. Pp. xii+298 (Toronto Old English Series 13). Toronto: University of Toronto Press, 2005. £48." Review of English Studies 57, no. 228 (2006): 136–38. http://dx.doi.org/10.1093/res/hgl017.

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35

Munawar, M., and R. L. Thomas. "Sediment toxicity testing in two areas of concern of the Laurentian Great Lakes: Toronto (Ontario) and Toledo (Ohio) Harbours." Hydrobiologia 176-177, no. 1 (1989): 397–409. http://dx.doi.org/10.1007/bf00026573.

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36

Snodgrass, William J., Ray Dewey, Michael D’Andrea, Rob Bishop, and Jian Lei. "Forecasting receiving water response to alternative control levels for combined sewer overflows discharging to Toronto’s Inner Harbour." Aquatic Ecosystem Health & Management 21, no. 3 (2018): 245–54. http://dx.doi.org/10.1080/14634988.2018.1507528.

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37

Zatzman, Matthew, Jennifer Seelisch, Federico Comitani, et al. "Abstract B026: Infant ALL without KMT2A rearrangements harbor clinically relevant alterations and share common origins with childhood ALL." Cancer Research 84, no. 17_Supplement (2024): B026. http://dx.doi.org/10.1158/1538-7445.pediatric24-b026.

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Abstract Infant acute lymphoblastic leukemia (ALL) is characterized by high frequency of rearrangements in KMT2A (KMT2Ar), associated with poor outcomes. Infants lacking KMT2Ar typically have superior outcomes, but remain understudied. Here, we use whole genome and transcriptome sequencing to define driver mutations and transcriptional phenotypes in non-KMT2Ar infant ALL. Based on two index cases, we initially suspected that some infants with high-risk clinical features harbored clinically undetected non-canonical alterations to the KMT2A gene; however, we find no such evidence in our data. In

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38

Cooper, Ashley L., Cassandra Carter, Hana McLeod, et al. "Detection of carbapenem-resistance genes in bacteria isolated from wastewater in Ontario." FACETS 6, no. 1 (2021): 569–91. http://dx.doi.org/10.1139/facets-2020-0101.

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Bacterial carbapenem resistance is a major public health concern since these antimicrobials are often the last resort to treat serious human infections. To evaluate methodologies for detection of carbapenem resistance, carbapenem-tolerant bacteria were isolated from wastewater treatment plants in Toronto, Ottawa, and Arnprior, Ontario. A total of 135 carbapenem-tolerant bacteria were recovered. Polymerase chain reaction (PCR) indicated the presence of carbapenem hydrolysing enzymes KPC ( n = 10), GES ( n = 5), VIM ( n = 7), and IMP ( n = 1), and β-lactamases TEM ( n = 7), PER ( n = 1), and OXA

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Chau, Y. K., and O. T. R. Kulikovsky-Cordeiro. "Occurrence of nickel in the Canadian environment." Environmental Reviews 3, no. 1 (1995): 95–120. http://dx.doi.org/10.1139/a95-004.

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Nickel is present in Canadian freshwater and terrestrial environments because of human activities including mining, smelting, refining, alloy processing, scrap metal reprocessing, other metal operations, fuel combustion, and waste incineration. Nickel can also enter the environment as a result of the natural weathering and leaching of rocks. Entry to the Canadian environment from anthropogenic activities results in measurable concentrations of nickel in various media to which organisms may be exposed. Although current anthropogenic rates of emission per tonne of nickel produced are less than 2

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Leiter, Sarah M., Aisosa Guobadia, Ben Fleming, et al. "Abstract A011 Molecular analysis improves the diagnosis of young people with renal tumors." Cancer Research 84, no. 17_Supplement (2024): A011. http://dx.doi.org/10.1158/1538-7445.pediatric24-a011.

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Abstract Background Accurate oncological diagnoses are essential to provide personalized and optimum care for patients. In children, renal tumors account for approximately one in 20 malignancies. Diagnostic workup in pediatric renal tumors is current focused on epidemiology, radiology, and histology, with a very limited role for molecular analysis outside of suspected cancer predisposition. Methods Retrospective clinical record review of seven pediatric and young adult renal tumor patients presenting to a single principal treatment center in the East of England, UK. Data collection was focused

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Stevens, Bradley T., Yang Zhang, Randolph K. Larsen, et al. "Abstract A001: PAX3-FOXO1-induced transcriptional dysregulation in rhabdomyosarcoma." Cancer Research 84, no. 17_Supplement (2024): A001. http://dx.doi.org/10.1158/1538-7445.pediatric24-a001.

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Abstract The survival rate for high-risk rhabdomyosarcoma (RMS) has not increased above 20% in the last thirty years. This insufficiency persists despite thorough molecular characterization of existing models and patient tumors, which has demonstrated that the most challenging RMS tumors harbor chromosomal translocations generating PAX3-FOXO1 (P3F) or PAX7-FOXO1 (P7F) oncofusion transcription factors. The presence of P3/7F largely explains the alveolar subtype of RMS. However, the molecular mechanisms by which P3/7F drives tumor onset and the extent to which they are required after establishme

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Laverty, Brianne, Shilpa Yadahalli, Vallijah Subasri, and David Malkin. "Abstract A010 The role of TP53 on transposable elements in pediatric cancer." Cancer Research 84, no. 17_Supplement (2024): A010. http://dx.doi.org/10.1158/1538-7445.pediatric24-a010.

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Abstract Background: Transposable elements (TEs) are dynamic repetitive regions which generate mutations and structural variants. TP53 plays a crucial role in suppressing TE movement to maintain genomic stability. The relationship between TP53 and TEs has been extensively studied in tumours, but not the germline. Individuals with germline TP53 pathogenic variants have Li-Fraumeni Syndrome (LFS), a cancer predisposition syndrome with a high lifetime risk of cancer in various tissues. This study aims to characterize the TE landscape in individuals with Li-Fraumeni Syndrome and determine how this

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Subasri, Vallijah, Benjamin Brew, Lauren Erdman, et al. "Abstract 1428: DNA methylation predicts early onset of primary tumor in patients with Li-Fraumeni syndrome." Cancer Research 82, no. 12_Supplement (2022): 1428. http://dx.doi.org/10.1158/1538-7445.am2022-1428.

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Abstract Background: Li-Fraumeni syndrome (LFS) is an autosomal dominant cancer predisposition syndrome. Approximately 80% of individuals with LFS harbor a germline TP53 pathogenic variant rendering them susceptible to a wide spectrum of early-onset malignancies. A comprehensive surveillance regimen termed the ‘Toronto Protocol’, has recently been adopted for early tumor detection, demonstrating significant improvement in survival among TP53 pathogenic variant carriers. However, the protocol’s “one-size-fits-all” approach fails to consider an individual patient's risk of cancer. We built a mac

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Wong, Stephanie WY, Carolina de Amat Herbozo, Adriana Vukosich-Pennell, Ben X. Wang, Pamela S. Ohashi, and Adrian G. Sacher. "Abstract B030: Characterizing MAIT cells in lung cancer: Insights from NSCLC and murine models." Cancer Immunology Research 11, no. 12_Supplement (2023): B030. http://dx.doi.org/10.1158/2326-6074.tumimm23-b030.

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Abstract Background: Mucosal-associated invariant T cells (MAIT) are unconventional αβT cells with a semi-invariant TCR that recognizes microbially-derived riboflavin metabolites presented by MHC-related protein 1 (MR1). Upon TCR engagement or cytokine stimulation, MAIT cells can rapidly secrete pro-inflammatory cytokines and cytotoxic molecules. The precise role of MAIT cells in the tumor-immune microenvironment remains unclear, as different reports have described them as either beneficial or detrimental to patient prognosis. Considering that MAIT cells constitute a notable proportion (2-4%)

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Merino-Galan, Leyre, Sergio Ortiz-Espinosa, Matthew Hathaway, et al. "Abstract B024: TrkB.T1 receptor promotes an immunosuppressive microenvironment driven by neutrophil recruitment in gliomas." Cancer Immunology Research 11, no. 12_Supplement (2023): B024. http://dx.doi.org/10.1158/2326-6074.tumimm23-b024.

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Abstract Gliomas are the most common type of brain tumor in both children and adults. Communication between cancer cells and the brain tumor microenvironment (TME) is a fundamental component of brain cancer pathophysiology. Glioma cells release factors that function as chemoattractants and influence the TME. Reciprocally, the activity of neurons from the surrounding TME drives the proliferation and growth of glial malignancies through paracrine signaling, brain-derived neurotrophic factor (BDNF) being a key secreted factor. BDNF binds with high affinity to the tropomyosin receptor kinase B (Tr

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Dickinson, Oliver. "Joseph W. Shaw & Maria C. Shaw (ed.). Kommos V: The Monumental Minoan Buildings at Kommos (Kommos, An Excavation on the South Coast of Crete by the University of Toronto under the auspices of the American School of Classical Studies at Athens, Volume V). xlii+1222 pages, 361 b&W & colour illustrations, 164 tables, 5 fold-out plans. 2006. Princeton (NJ) & Woodstock: Princeton University Press; 0-691-12123-0 hardback $195 & £125. - Joseph W. Shaw. Kommos, a Minoan Harbour Town and Greek Sanctuary in Southern Crete. 171 pages, 77+ b&w & colour illustrations. 2006. Athens: American School of Classical Studies at Athens; 0-87661-659-7 paperback £16.95." Antiquity 80, no. 310 (2006): 1013–14. http://dx.doi.org/10.1017/s0003598x00094667.

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Vasquez, Juan C., Prateek Bhardwaj, Sophia Zhao, et al. "Abstract A081 Biomarker-driven targeting of NAD metabolism in rhabdomyosarcoma." Cancer Research 84, no. 17_Supplement (2024): A081. http://dx.doi.org/10.1158/1538-7445.pediatric24-a081.

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Abstract Introduction/Background: New treatments are needed to improve survival in rhabdomyosarcoma (RMS). Cells primarily synthesize nicotinamide adenine dinucleotide (NAD+) through the Preiss-Handler and Salvage pathways driven by nicotinic acid phosphoribosyltransferase (NAPRT) and nicotinamide phosphoribosyltransferase (NAMPT), respectively. NAMPT inhibitors (NAMPTi) have been tested in clinical trials, but their efficacy has been limited by lack of appropriate biomarkers for patient selection. Here, we sought to determine if RMS harbors NAPRT silencing that confers a synthetic lethal inte

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Treger, Taryn D., Jenny Wegert, Anna Wenger, et al. "Abstract PR002: Somatic genetic development of Wilms tumor via normal kidneys in predisposed children." Cancer Research 84, no. 17_Supplement (2024): PR002. http://dx.doi.org/10.1158/1538-7445.pediatric24-pr002.

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Abstract Ten percent of children with cancer harbor a predisposition mutation, and in children with the kidney cancer, Wilms tumor, the prevalence may be as high as 30%. Whilst clinical management of children with a known predisposition differs from that of children with sporadic Wilms tumors, it is not dependent on the type of predisposition. Some Wilms predispositions are associated with defined histological and clinical features, which suggests differences in the genetic development of such tumors. To investigate this, we assembled a cohort of 137 children with Wilms tumor, of whom 71 were

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Chauvin, Céline, Mamy Andrianteranagna, Sandrina Turczynski, et al. "Abstract A050 DNMT3B DNA methyltransferase acts as a major player and therapeutic target in rhabdoid tumors." Cancer Research 84, no. 17_Supplement (2024): A050. http://dx.doi.org/10.1158/1538-7445.pediatric24-a050.

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Abstract Rhabdoid tumors (RTs) are highly aggressive pediatric malignancies which occur in kidney, soft-parts and brain, where they are named AT/RT. RTs are characterized by the inactivation of the SMARCB1 tumor suppressor gene encoding a core subunit of the chromatin remodeling SWI/SNF complex, which is the only recurrent genetic event, rendering this malignancy a prototype of epigenetically-driven cancers. Hence, targeting epigenetic modifyers by so-called « epidrugs » is an attractive hypothesis for treatment of RTs. Interestingly, several studies have pointed out the overexpression of de n

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Wei, Yun, Luis Antonio Corchete Sanchez, Diego Antelo, et al. "Abstract PR012: MYOD1L122R induces chemoresistance and elevates cancer stem cell programs through WNT11-ROR2-VANGL2 signaling in aggressive rhabdomyosarcoma." Cancer Research 84, no. 17_Supplement (2024): PR012. http://dx.doi.org/10.1158/1538-7445.pediatric24-pr012.

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Abstract Background: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood or adolescents. The spindle sclerosing (ss-RMS) subtype has the worst outcome of all RMS patients and often harbor recurrent mutation of Leucine 122 to Arginine within the DNA binding domain of the transcription factor MYOD1. To date, the molecular function of MYOD1L122Rremains largely unknown. Methods: Here, we create the first animal model of MYOD1L122R using transgenic zebrafish. We also used CRISPR-homology-directed-repair and dox-inducible systems to express MYOD1L122R in human RMS cells. These

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