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Journal articles on the topic 'Total bilirubin'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Ball, Matthew, Irene Miller, and Steven W. Cotten. "Direct Bilirubin Higher Than Total Bilirubin?" Clinical Chemistry 61, no. 6 (2015): 889. http://dx.doi.org/10.1373/clinchem.2014.237040.

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2

Rosenthal, P., M. T. Keefe, D. Henton, et al. "Total and direct-reacting bilirubin values by automated methods compared with liquid chromatography and with manual methods for determining delta bilirubin." Clinical Chemistry 36, no. 5 (1990): 788–91. http://dx.doi.org/10.1093/clinchem/36.5.788.

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Abstract This study compares total and direct-reacting bilirubin values in 40 serum samples from patients with various diagnoses, as measured by automated methods (Beckman Synchron CX-5, Beckman Astra 8, Kodak Ektachem 700) and HPLC and by a manual method for delta bilirubin. For total bilirubin, within-run CVs were less than 6%. The Ektachem 700 method underestimated bilirubin with serum samples from patients with Crigler-Najjar syndrome and from newborns in whom unconjugated bilirubin concentrations were increased but conjugated bilirubins were not present or were present only in small amoun

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3

Rothuizen, Jan, and Ted van den Ingh. "Covalently protein-bound bilirubin conjugates in cholestatic disease of dogs." American Journal of Veterinary Research 49, no. 5 (1988): 702–4. https://doi.org/10.2460/ajvr.1988.49.05.702.

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SUMMARY We investigated the occurrence of covalently protein-bound bilirubins in the plasma of dogs with hyperbilirubinemia attributable to hepatobiliary diseases or Coombs test-positive hemolysis. The bilirubins in plasma were measured with the conventional Van den Bergh reaction, by treatment with diazotized p-iodoaniline, and by high-performance liquid chromatography of bilirubin and its methylesters after alkaline methanolysis. All but one dog had covalently protein-bound bilirubin conjugates. The concentration and the fraction of total bilirubins varied in all diseases investigated, but t

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4

Manasa, D. R., H. M. Lokesh, B. Yadgude Ramkrishna, et al. "Analyzing the Stability of Stored Serum of Different Biochemical Parameters on Different Days." International Journal of Pharmaceutical and Clinical Research 16, no. 12 (2024): 221–25. https://doi.org/10.5281/zenodo.14591874.

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<strong>Background:</strong> Sample repository is noteworthy, especially in cases of many scientific & medical processes that expedite diagnosis & treatment design. Furthermore, to know the sample integrity which can impact on providing accurate or reproducible data. <strong>Materials & Methods:</strong> A, total of 11 biochemical parameters were gauged by taking 13 patients’ serum samples at Chikkamagaluru Institute of Medical Sciences, Chikkamagaluru. Each patient’s serum was stowed in an aliquot at -20<sup>ο</sup>C for a month. Initial analysis

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5

He, Yujian, Jingjing Zhu, Fei Xiao, et al. "Association of Different Total Bilirubin Levels with Prognosis of Peritoneal Dialysis-Associated Peritonitis." Medicina 59, no. 10 (2023): 1837. http://dx.doi.org/10.3390/medicina59101837.

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Background and Objectives: Peritoneal dialysis-associated peritonitis (PDAP) poses significant challenges in peritoneal dialysis (PD) patient management and outcomes. Total bilirubin has gained attention due to its antioxidant and immunomodulatory properties. However, its relationship with PDAP prognosis remains underexplored. Materials and Methods: We conducted a retrospective single-center study involving 243 PDAP patients stratified into tertile-based groups according to total bilirubin levels. The association between total bilirubin levels and treatment failure risk was investigated throug

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6

Langbaum, M. E., S. J. Farber, and P. Rosenthal. "Automated Total and Neonatal Bilirubin Values in Newborns: Is a Distinction Clinically Relevant?" Clinical Chemistry 38, no. 9 (1992): 1690–93. http://dx.doi.org/10.1093/clinchem/38.9.1690.

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Abstract Guidelines for managing hyperbilirubinemia in newborns were developed by using diazo methods that measure total and direct-reacting bilirubins and calculate an indirect fraction. The automated Kodak Ektachem system allows for measuring serum bilirubin by either of two dry-slide methods: TBIL, involving a modified diazo method, and NBIL, involving a dual-wavelength colorimetric method that fractionates and directly measures the unconjugated (Bu) and conjugated (Bc) bilirubins (Bu+Bc = neonatal bilirubin). The manufacturer recommends that NBIL be used in newborns less than 15 days old,

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7

Sarmin, Sarmin, Pudji Astuti, Claude Mona Airin, and Nur Adianto. "Profil Total Bilirubin, Aktivitas Alanine Transaminase danTotal Protein Domba Garut pada Umur danStatus Fisiologis yang Berbeda." Jurnal Veteriner 23, no. 3 (2022): 433–40. http://dx.doi.org/10.19087/jveteriner.2022.23.3.432.

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Tujuan peneltiian ini adalah mengkaji profil total bilirubin, aktivitas ALT, dan total protein domba garut pada umur dan status fisiologis yang berbeda. Sebanyak 36 ekor domba garut dengan berbagai kondisi fisiologis (domba betina, domba jantan, anak domba betina, anak domba jantan, anak domba lepas sapih betina, anak domba lepas sapih jantan, domba jantan muda umur enam bulan, domba jantan muda umur satu tahun, domba bunting dan domba laktasi) digunakan dalam peneltian ini. Sampel darah diambil melalui vena jugularis pada pagi hari sebelum domba diberi pakan., selanjutnya dianalisis nilai tot

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8

Sofyanita, Eko Naning, Endang Susilowaty, and Roni Afriansya. "The Effect of Light Exposure to Bilirubine Levels on Serum Jaundice Infant in Hospital of Islamic NU Demak." Borneo Journal of Medical Laboratory Technology 3, no. 1 (2020): 168–71. http://dx.doi.org/10.33084/bjmlt.v3i1.1766.

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Bilirubin is a substance formed from the normal breakdown of erythrocytes in the body so that it gives a yellow color to the stool and urine. The test of bilirubin in the laboratory must avoid exposure to light, which can cause decreased serum bilirubin levels by up to 50% in 1 hour due to disruption of the bilirubin's stability. This study is a cross-sectional analytic study of primary data using 30 samples of jaundice baby serum and direct and total bilirubin test. Data collection was conducted from the primary data by a direct test using 40 samples of infant jaundice and test of direct bili

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9

Perry, B., B. T. Doumas, G. Buffone, M. Glick, C. N. Ou, and K. Ryder. "Measurement of total bilirubin by use of bilirubin oxidase." Clinical Chemistry 32, no. 2 (1986): 329–32. http://dx.doi.org/10.1093/clinchem/32.2.329.

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Abstract We used an enzymatic method for measuring total bilirubin in serum. Results by this method varied linearly with bilirubin concentrations to at least 300 mg/L. The day-to-day precision (CV) of the method ranged from less than 1% to about 11% at bilirubin concentrations of 183 and 12 mg/L, respectively. Commonly used anticoagulants, serum preparation materials, and selected drugs had no effect on the apparent bilirubin concentration, but turbidity caused a slight increase and hemoglobin concentrations of 2 g/L resulted in lower values, by as much as 17 mg/L at a bilirubin concentration

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10

Gupta, BK, N. Chaudhary, BD Bhatia, and Binod Gupta. "Non invasive trans-cutaneous bilirubin as a screening test to identify the need for serum bilirubin assessment in healthy term neonates." Journal of Universal College of Medical Sciences 1, no. 4 (2014): 17–21. http://dx.doi.org/10.3126/jucms.v1i4.9567.

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INTRODUCTION: Hyperbilirubinemia is a common problem in the neonates. It can progress to develop kernicterus unless intervention is initiated. Severity of jaundice and decision for management are usually based on total serum bilirubin (TsB) estimation which technique and results closely correlates with total serum bilirubin levels. OBJECTIVES: To compare the accuracy of visual assessment of jaundice by single trained observer based on Kramer's index with total serum bilirubin levels in healthy term neonates. To compare accuracy of non invasive bilirubin assessment with serum bilirubin levels,

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11

Turnell, D. C. "The Calibration of Total Serum Bilirubin Assays." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 22, no. 3 (1985): 217–21. http://dx.doi.org/10.1177/000456328502200301.

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Bilirubin assays yield variable results due to the lack of a universal calibrant. The preparation of a bilirubin calibrant is associated with the following problems: (a) only unconjugated bilirubin is available in a ‘pure’ form and this is of doubtful stability, (b) the test for its purity is arbitrary, (c) the true molar absorptivity of bilirubin is unknown, (d) due to the various specificities of methods, the calibrant has to be in a protein matrix, (e) the matrix alters the properties of bilirubin and (f) there is no definitive bilirubin assay. The use of a lyophilised human-based bilirubin

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12

Mahmoud Elhabiby, Mahmoud, Ayman Abu Mustafa, and Abdelmarouf Mohieldein. "Effect of Seasonal Variation on the Bilirubin Content and Hematological Indices among Neonates in Southern Gaza, Palestine." Global Journal of Health Science 15, no. 5 (2023): 24. http://dx.doi.org/10.5539/gjhs.v15n5p24.

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BACKGROUND &amp; OBJECTIVES: Premature newborns&rsquo; bilirubin conjugation and excretion mechanisms are undeveloped. Seasonal changes and other variables affect the severity of newborns&rsquo; physiological jaundice. This study examined blood indices, bilirubin levels, and birth season in neonates in the southern Gaza Strip of Palestine.  METHODS: A cross-sectional study of 366 neonates aged one to 14 days was conducted in Medical Nasser Complex-Southern Gaza, Palestine.The newborns were divided into four groups based on season of birth: spring (n=72), winter (n=96),

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13

Santosa, Budi, and Siti Istiqomah. "KADAR BILIRUBIN PASCA FOTOTERAPI PADA BAYI DI RSIA FATMA BOJONEGORO." Klinikal Sains : Jurnal Analis Kesehatan 11, no. 1 (2023): 71–79. http://dx.doi.org/10.36341/klinikal_sains.v11i1.3324.

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Salah satu fenomena yang masih banyak dijumpai pada bayi baru lahir adalah terjadinya Hiperbilirubinemia. Fototerapi adalah salah satu penanganan untuk menghindari kondisi yang lebih fatal. Tujuan penelitian adalah untuk melihat pengaruh fototerapi terhadap kadar bilirubin total pada bayi yang mengalami hiperbilirubinemia. Metode penelitian analitik observasional dilakukan pada populasi bayi yang mengalami ikterus di RSIA Fatma Bojonegoro. Teknik sampling berupa total populasi sebanyak 110 responden melalui data rekam medis. data berupa karakteristik responden, fototerapi, dan kadar bilirubun

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14

Err, Hai, and Viroj Wiwanitkit. "Total bilirubin in nasogastric aspirate." African Journal of Paediatric Surgery 10, no. 4 (2013): 394. http://dx.doi.org/10.4103/0189-6725.125460.

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15

Phattraprayoon, Nanthida, Kamonwan Soonklang, Peeraya Amnucksoradeja, and Tanin Pirunnet. "Correlation of microbilirubin with total serum bilirubin and transcutaneous bilirubin." PLOS One 20, no. 6 (2025): e0324201. https://doi.org/10.1371/journal.pone.0324201.

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Jaundice is a common condition in newborns that requires early detection. Screening for neonatal jaundice involves measuring microbilirubin (MB), total serum bilirubin (TSB), and transcutaneous bilirubin (TcB). This study aimed to examine the correlation between bilirubin levels obtained from these three measurements: MB, TSB, and TcB. The cross-sectional study included infants with a gestational age (GA) of 35 weeks or more who met the criteria for jaundice screening or exhibited signs of jaundice. Bilirubin levels were simultaneously measured using MB, TSB, and TcB at both the forehead and s

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16

Kosim, M. Sholeh, Robert Soetandio, and M. Sakundarno. "Dampak Lama Fototerapi Terhadap Penurunan Kadar Bilirubin Total pada Hiperbilirubinemia Neonatal." Sari Pediatri 10, no. 3 (2016): 201. http://dx.doi.org/10.14238/sp10.3.2008.201-6.

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Latar belakang. Fototerapi dapat menurunkan kadar bilirubin total namun lama pemberian fototerapi masih belum jelas. Fototerapi di RS dr Kariadi biasanya dilakukan selama 12-24 jam berturut-turut tanpa memandang kadar bilirubin total awal.Tujuan. Menganalisis perbedaan rata-rata penurunan kadar bilirubin total dalam 6 jam, 12 jam, 18 jam, dan 24 jam setelah pemberian fototerapi.Metode. Penelitian kuasi eksperimental pada 40 neonatus hiperbilirubinemia, dibagi 4 kelompok (kelompok I: bilirubin total 13-15 mg/dL, fototerapi 6 jam; kelompok II: 16-17 mg/dL, fototerapi 12 jam; kelompok III: 18-20

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17

Shihadeh, Manal D., Deena Kheyami, and Mona Al Jufairi. "Transcutaneous Bilirubin Measurement Correlation with Total Serum Bilirubin in Healthy Newborns." Bahrain Medical Bulletin 38, no. 4 (2016): 208–10. http://dx.doi.org/10.12816/0047507.

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18

Pyrkov, L. M., T. A. Sokolova, L. G. Kopyakova, and I. S. Rozen. "Microassay of total serum bilirubin on the ABFTs-1 bilirubin analyzer." Biomedical Engineering 20, no. 5 (1986): 156–57. http://dx.doi.org/10.1007/bf00563381.

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19

Poon, R., and I. H. Hinberg. "Indican interference with six commercial procedures for measuring total bilirubin." Clinical Chemistry 31, no. 1 (1985): 92–94. http://dx.doi.org/10.1093/clinchem/31.1.92.

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Abstract We have studied the effect of indican on six commercial procedures for the measurement of total bilirubin in serum. Total bilirubin measured by the Bilirubin A-Gent (Abbott) 2,4-dichlorophenyl diazonium procedure increased by 50 mg/L for each 1 mmol/L of added indican. Similarly, total bilirubin measured by the Bilirubin C-System (Boehringer Mannheim) 2,5-dichlorophenyl diazonium procedure increased by 33 mg/L per mmol/L of indican. Indican also interfered with the Micro Bilirubin Reagent Set (Harleco) Malloy-Evelyn procedure, but to a much lesser extent. The Jendrassik Bilirubin Reag

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20

Chan, K. M., M. G. Scott, T. W. Wu, et al. "Inaccurate values for direct bilirubin with some commonly used direct bilirubin procedures." Clinical Chemistry 31, no. 9 (1985): 1560–63. http://dx.doi.org/10.1093/clinchem/31.9.1560.

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Abstract We compared five methods for the determination of total and direct bilirubins in serum samples from normal controls, subjects with Gilbert's syndrome, and serum pools containing about 50 and 150 mg of total bilirubin per liter. The Kodak Ektachem method and a diazotized sulfanilic acid method with 0.15 mmol/L sodium nitrite concentrations are the only methods that gave accurate direct bilirubin values, as judged by liquid-chromatographic results. The aca method that involved p-nitrobenzene diazonium tetrafluoroborate and another diazotized sulfanilic acid method with a higher concentr

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Chae, Hyojin, Woojae Kwoun, Jeong Joong Lee, and Young-Ah Youn. "Comparative analysis of the quantitative point-of-care CareSTART™ total bilirubin with central laboratory total bilirubin assays in neonatal blood samples." Medicine 103, no. 21 (2024): e38267. http://dx.doi.org/10.1097/md.0000000000038267.

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This study aimed to assess and compare the accuracy of point-of-care CareSTART™ S1 Total Bilirubin test with a central laboratory total bilirubin assay using neonatal samples. This study was conducted using 152 paired measurements obtained from 122 neonates admitted to the neonatal intensive care unit. Total serum bilirubin (TSB) levels assayed with the central laboratory assay, laboratory bilirubinomter, trancutaneous bliribubin (TcB) instrument and CareSTART were compared using Bland-Altman analysis. The mean difference between the CareSTART and TSB values was −1.43 mg/dL and the 95% limit o

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Bekbossynova, M., T. Ivanova-Razumova, G. Daniyarova, and S. Khamitov. "ASSOCIATION BETWEEN TOTAL BILIRUBIN LEVELS WITH INCIDENCE OF ATHEROSCLEROSIS: SYSTEMATIC REVIEW AND META-ANALYSIS." BULLETIN OF SURGERY IN KAZAKHSTAN 20, no. 2 (2024): 32–38. http://dx.doi.org/10.35805/bsk2024ii004.

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Background. Bilirubin is a byproduct of the breakdown of erythrocytes. Bilirubin levels can potentially serve as a biomarker for cardiovascular risk assessment. In this study, we would be investigating most recent manuscripts, published in the last 5 years, that studied association of serum bilirubin level to atherosclerosis progression to elicit how strongly low level of total bilirubin can prognose the disease progression. Methods. Using Pubmed search engine, all articles that included keywords “bilirubin” and “atherosclerosis” were retrieved. In total 67 search results emerged for the 2019-

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Kesuma, Suryanata, Siti Rodiyah, and Maulida. "EVALUASI PEMERIKSAAN BILIRUBIN TOTAL MENGGUNAKAN MODEL SPECIMEN INSIGNIFICANT DAN MILD HEMOLYSIS." GEMA KESEHATAN 15, no. 2 (2023): 139–50. http://dx.doi.org/10.47539/gk.v15i2.428.

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Bilirubin total merupakan salah satu pemeriksaan fungsi hati. Pemeriksaan bilirubin total umumnya menggunakan sampel darah yang tidak boleh hemolisis, sehingga sampel hemolisis menjadi salah satu faktor yang dapat mempengaruhi hasil pemeriksaan bilirubin total. Hemolisis dapat terjadi secara in vivo dan in vitro. Hemolisis secara in vitro menyebabkan kesalahan pemeriksaan bilirubin total. Tujuan penelitian ini untuk mengetahui hasil evaluasi pemeriksaan bilirubin total menggunakan model specimen insignificant dan mild hemolysis. Metode penelitian ini adalah kuasi eksperimen. Pembuatan hemolisa

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Zhang, Hui, Guizhao Yang, Rongqiong Jiang, et al. "Correlation Between Total Bilirubin, Total Bilirubin/Albumin Ratio with Disease Activity in Patients with Rheumatoid Arthritis." International Journal of General Medicine Volume 16 (January 2023): 273–80. http://dx.doi.org/10.2147/ijgm.s393273.

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25

Neocleous, Charalambos, Alkistis Adramerina, Stefanos Limnaios, et al. "A Comparison between Transcutaneous and Total Serum Bilirubin in Healthy-term Greek Neonates with Clinical Jaundice." Prague Medical Report 115, no. 1-2 (2014): 33–42. http://dx.doi.org/10.14712/23362936.2014.4.

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The accuracy of transcutaneous bilirubin meters has been assessed in newborns from various ethnic backgrounds. However, there are limited data on Greek newborns. Our study examined the accuracy of transcutaneous bilirubin measurements in clinically jaundiced healthy-term Greek newborns, using total serum bilirubin as the reference standard, in order to re-evaluate our local guidelines about neonatal jaundice. Clinically jaundiced newborns requiring total serum bilirubin level estimation were recruited prospectively. 368 pairs of total serum bilirubin/transcutaneous bilirubin measurements were

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Fajrian, Fatima Maulidina. "Enzim Transferase dengan Bilirubin Total Penderita Ikterus Obstruktif." Jurnal Ilmiah Kesehatan Sandi Husada 11, no. 1 (2020): 176–82. http://dx.doi.org/10.35816/jiskh.v11i1.240.

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Ikterus obstruktif post-hepatik merupakan ikterus yang terjadi akibat adanya suatu sumbatan pada saluran empedu yang mengakibatkan terjadinya gangguan aliran empedu antara organ hati dengan duodenum. Fungsi hati dapat diukur dengan cara memeriksa aktivitas enzim serum, salah satunya serum aminotransferase yaitu Serum Glutamic Oxaloacetic Transaminase (SGOT) dan Serum Glutamic Piruvic Transaminase (SGPT). SGOT, SGPT dan bilirubin merupakan salah satu produksi dari hati yang dimana jika terjadi kerusakan hati maka akan terjadi kelainan pada hasil enzim hati dan bilirubin total. Tujuan penelitian

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Nitish, Kumar. "A Prospective Observational Study to Assess the Diagnostic Efficacy of total TLC, CRP and Total Bilirubin in Acute Appendicitis." International Journal of Pharmaceutical and Clinical Research 14, no. 4 (2022): 52–59. https://doi.org/10.5281/zenodo.13835176.

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<strong>Aim:</strong> To study the diagnostic value of total leucocytes count, C-reactive protein and total bilirubin in acute appendicitis: a prospective study. <strong>Methods: </strong>This study was performed on 45 patients who have clinically and radiologically diagnosed of having acute appendicitis. All patients fulfilled all the inclusion criteria like all clinically and radiologically diagnosed cases of acute appendicitis and its complications will be included in present study and Patients with hepatic disorders, a history of alcohol intake with AST/ALT >2, A history

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Slusher, T. M., I. A. Angyo, F. Bode-Thomas, et al. "Transcutaneous Bilirubin Measurements and Serum Total Bilirubin Levels in Indigenous African Infants." PEDIATRICS 113, no. 6 (2004): 1636–41. http://dx.doi.org/10.1542/peds.113.6.1636.

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Venkatesan, Mohanram, Arulraj Russelian, and Palpandi Velimuthu. "Correlation of transcutaneous bilirubin with total serum bilirubin in neonates with hyperbilirubinemia." International Journal of Contemporary Pediatrics 8, no. 7 (2021): 1256. http://dx.doi.org/10.18203/2349-3291.ijcp20212322.

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Background: For determining hyperbilirubinemia in a neonate, clinical evaluation, serum bilirubin estimation and trans cutaneous bilirubin estimation are the modalities available. Transcutaneous bilirubinometry (TcB) is routinely used to monitor jaundice in term and near-term infants. Literature shows a positive correlation observed between TcB and total serum bilirubin (TSB). The present study was conducted determine the correlation of TcB with TSB in neonates with hyperbilirubinemia admitted at a tertiary care hospital, ChennaiMethods: A cross sectional study was conducted at a tertiary care

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Shrestha, Sandeep, Binod Man Shrestha, and Bina Prajapati. "COMPARISON OF TOTAL SERUM BILIRUBIN AND TRANSCUTANEOUS BILIRUBIN IN NEONATES WITH HYPERBILIRUBINAEMIA." Journal of Chitwan Medical College 12, no. 1 (2022): 121–25. http://dx.doi.org/10.54530/jcmc.670.

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Background: Jaundice is considered as one of the most prevalent and common clinical problems during neonatal period which may require interventional treatment. Transcutaneous bilirubinometry is a simple method for estimating bilirubin levels and diagnosing jaundice in neonates. This study was done to compare transcutaneous bilirubin and total serum bilirubin in jaundiced neonates. Methods: A hospital based prospective cross-sectional study of neonates from Out Patient Department, Emergency Ward, and Neonatal Intensive Care Unit with clinical jaundice was conducted between January 2016 and Dece

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Muliana, Cut, Isra Firmansyah, Eka Yunita Amna, Syafruddin Haris, Sulaiman Yusuf, and Zaki Akbar. "Hubungan Kadar Bilirubin Transkutan dengan Bilirubin Serum Total pada ikterus Neonatorum di Rumah Sakit Umum dr. Zainoel Abidin Banda Aceh." Syntax Literate ; Jurnal Ilmiah Indonesia 9, no. 11 (2024): 6537–43. http://dx.doi.org/10.36418/syntax-literate.v9i11.52280.

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Ikterus pada minggu pertama kehidupan ditemukan 60% pada neonatus cukup bulan dan 80% pada neonatus kurang bulan. Pemeriksaan kadar bilirubin penting dalam membedakan hiperbilirubinemia fisiologis dan patologis pada neonatus, juga untuk menentukan pengobatan pada ikterus neonatorum. Selama ini penentuan kadar bilirubin dilakukan dengan pemeriksaan serum darah vena, namun memiliki beberapa efek samping. Pengukuran bilirubin transkutan merupakan metode non-invasif untuk mengukur kadar bilirubin pada bayi baru lahir. Penelitian ini bertujuan untuk mengetahui korelasi kadar bilirubin transkutan de

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Fadhilah, Fitri. "PENGARUH LAMANYA PENCAHAYAAN TERHADAP KADAR BILIRUBIN TOTAL METODE KOLORIMETRIC DIAZO." Klinikal Sains : Jurnal Analis Kesehatan 7, no. 1 (2019): 1–7. http://dx.doi.org/10.36341/klinikal_sains.v7i1.597.

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Pemeriksaan laboratorium klinik merupakan system yang dapat menentukan keputusan mengenai suatu diagnosis penyakit melalui hasil laboratorium. Pemeriksaan laboratorium klinik dengan hasil yang berkualitas sangat diperlukan, salah satu pemeriksaan laboratorium yang harus dijaga kualitasnya adalah tentang penanganan sampel. Penanganan sampel yang baik memberikan hasil penanganan spesimen yang akurat, pemeriksaan yang membutuhkan penanganan sampel yang baik seperti pada pengukuran bilirubin karena mudah berubah ke stabilannya sehingga perlu pemeriksaan segera. Jenis penelitian ini merupakan ekspe

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Gulian, Jean-Marc, Christiane Dalmasso, and Veronique Gonard. "Interaction of Beta-Lactam Antibiotics on Bilirubin-Albumin Complex: Comparison by Three Methods, Total Bilirubin, Unbound Bilirubin and Erythrocyte-Bound Bilirubin." Chemotherapy 36, no. 2 (1990): 91–97. http://dx.doi.org/10.1159/000238753.

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Hao, Lu, Qiuyan Chen, Xi Chen, and Qing Zhou. "Association of Serum Total Bilirubin Concentration with Telomere Length: The National Health and Nutrition Examination Survey." Oxidative Medicine and Cellular Longevity 2021 (September 23, 2021): 1–11. http://dx.doi.org/10.1155/2021/4688900.

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Introduction. Mildly increased bilirubin concentration has a protective effect on oxidative stress–related diseases. However, it remains unknown whether elevated circulating bilirubin is associated with longer telomere length. The aim of this cross-sectional study was to examine the association between total bilirubin concentration and telomere length. Methods. We used the data from the National Health and Nutrition Examination Survey (NHANES) 1999-2002. The multivariable linear regression model was used to examine the association between total bilirubin concentration and telomere length. The

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Mithila, Das Mazumder, and D'souza Joy. "Assessing Bilirubin Measures: Serum Vs Transcutaneous in Neonates." International Journal of Pharmaceutical and Clinical Research 16, no. 2 (2024): 1017–22. https://doi.org/10.5281/zenodo.11077534.

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<strong>Background:</strong> Neonatal Icterus in in newborns is a serious condition. It’s one of the most common reasons of infant immaturity. The total investigation of complete serum bilirubin (TSB) is a widely known procedure for identifying hyperbilirubinemia, but it is intrusive for neonates. TCB (TCB) was used to assess bilirubin levels since over 2 decades as just a non-invasive and painless method. Acute bilirubin encephalopathy, commonly referred as kernicterus, is indeed a bilirubin toxicity which is linked to significant morbidity and mortality. The focus of this research

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Nilsen, Dennis Winston T., Peder Langeland Myhre, Svein Solheim, et al. "Total Bilirubin Yields Prognostic Information Following a Myocardial Infarction in the Elderly." Antioxidants 12, no. 6 (2023): 1157. http://dx.doi.org/10.3390/antiox12061157.

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Total bilirubin consists of an unconjugated form, solubilized by its binding to albumin, and a conjugated form representing a minor part of the circulating bilirubin. As total bilirubin in physiological concentrations is a powerful antioxidant, its concentration gradient may reflect the health status of an individual, and serve as a prognostic indicator of outcome in primary and secondary cardiovascular disease prevention. The aim of this study was to assess the association between total bilirubin and incident cardiovascular events following a myocardial infarction. Total bilirubin in serum wa

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Muhammad Shahid, Anum Zia, Aqsa Mazhar, Faez Qasem Mohammad Hassan, Saad Muhammad Shahid, and Nida Aslam. "CORRELATION BETWEEN TOTAL SERUM BILIRUBIN LEVELS AND TRANSCUTANEOUS BILIRUBINOMETER VALUES IN NEONATAL JAUNDICE." Pakistan Postgraduate Medical Journal 35, no. 01 (2024): 3–6. http://dx.doi.org/10.51642/ppmj.v35i01.645.

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Background: Jaundice in newborns is a prevalent postnatal complication, typically benign in nature. To assess neonatal jaundice, the development of non-invasive techniques, such as the transcutaneous bilirubinometer, has proven instrumental. This study focuses on evaluating neonatal bilirubin levels using transcutaneous bilirubin (TcB) meters, which employ a non-invasive approach by measuring light transmission through the skin. Objective: The objective of this research is to conduct a comparative analysis between transcutaneous bilirubin levels in neonates and their corresponding total

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Alsaeedi, Bahjat Abdulridha, Razan Ali Mohammed, and Waad Edan Louis Al-Rubaye. "A Comparative Study between Transcutaneous Bilirubinometry and Total Serum Bilirubin Measurement in Jaundiced Newborns." AL-Kindy College Medical Journal 18, no. 2 (2022): 148–55. http://dx.doi.org/10.47723/kcmj.v18i2.787.

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Background: Drawing blood to measure total serum bilirubin is painful & time consuming. Transcutaneous bilirubinometer working by multiwavelength spectral reflectance from the skin surface on forehead or upper sternum is a quick & painless technique. Objectives: to compare the effectiveness of transcutaneous (over the upper sternum and forehead) and serum bilirubin measurement of neonate with jaundice. Subjects and Methods: This is a cross sectional prospective study. It enrolled 175 jaundiced neonates & excluded those exposed to phototherapy. It was conducted at Child Central Teac

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Yakovleva, M. S., N. S. Yakovleva, N. A. Gotovchikov, S. N. Tishkov, and L. P. Ermakova. "DOSE-DIFFERENTIATED CORRELATION INTERACTIONS BETWEEN INDICES OF HEMOGLOBIN EXCHANGE IN TURKEYS UNDER THE INFLUENCE OF THE PROBIOTIC FORMULATION VETOM 1.2." Bulletin of NSAU (Novosibirsk State Agrarian University), no. 1 (March 22, 2020): 82–91. http://dx.doi.org/10.31677/2072-6724-2020-54-1-82-91.

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The effect of the probiotic preparation Vetom 1.2 on the basis of Bacillus subtilis VKPM B-10641, Bacillus amyloliquefaciens VKPM B-10642 and Bacillus amyloliquefaciens VKPM B-10643 in different doses on the correlation interactions between the parameters of turkey hemoglobin exchange, blood erythrocytes and blood red blood cells direct and total bilirubin, total protein and serum albumin was studies. Correlations were calculated using Spearman formula, the reliability of correlations was checked by Student. The formulation was used for turkeys once a day for 30 days in doses of 12.5; 25; fift

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Alyousef, Tareq, Kumar Kunnal Batra, Harsha v. Poola, et al. "A Phenomenon of Normal Total Bilirubin with Increased Direct Bilirubin Noted In Patients with Plasma Cell Dyscrasias." Blood 116, no. 21 (2010): 4986. http://dx.doi.org/10.1182/blood.v116.21.4986.4986.

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Abstract Abstract 4986 Introduction: One of the authors noted the phenomenon of increased direct bilirubin with normal total bilirubin in patients with multiple myeloma and other plasma cell dyscrasias seen at our institute. This triggered a literature search regarding the same. Gammopathy interference in automated chemistry assays has been described before. Increased serum total bilirubin levels have been reported in patients with monoclonal gammopathy. There is also one report of decrease in direct bilirubin due to paraprotein interference. As far as we know the phenomenon noted by us has ne

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Lee, Zon-Min, Ling-Sai Chang, Kuang-Che Kuo, Meng-Chiao Lin, and Hong-Ren Yu. "Impact of Protein Binding Capacity and Daily Dosage of a Drug on Total Serum Bilirubin Levels in Susceptible Infants." Children 10, no. 6 (2023): 926. http://dx.doi.org/10.3390/children10060926.

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Hyperbilirubinemia is a common pathological condition in neonates. Free bilirubin can penetrate the blood–brain barrier (BBB), which can lead to bilirubin neurotoxicity. In the context of predicting the risk of bilirubin neurotoxicity, although the specificity and sensitivity of free bilirubin levels are higher than those of total serum bilirubin (TSB), free bilirubin is not widely monitored in clinical practice. The threshold TSB levels at which phototherapy must be administered have been established previously. However, TSB levels are not well correlated with neurodevelopmental outcomes. Cur

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Ye, Man-Li, and Jie-Ke Wang. "Association of total bilirubin with depression risk in adults with diabetes: A cross-sectional study." World Journal of Clinical Cases 12, no. 18 (2024): 3428–37. http://dx.doi.org/10.12998/wjcc.v12.i18.3428.

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BACKGROUND Individuals with diabetes mellitus are more likely to experience depression, although most patients remain undiagnosed. The relation between total bilirubin and depression has been increasingly discussed, but limited studies have examined the association of total bilirubin with depression risk in adults with diabetes, which warrants attention. AIM To investigate the association between total bilirubin levels and the risk of depression in adults with diabetes. METHODS The study included adults with diabetes from the National Health and Nutrition Examination Survey 2007-2018. Depressi

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Ihara, H., H. Nakamura, Y. Aoki, T. Aoki, and M. Yoshida. "In Vitro Effects of Light on Serum Bilirubin Subfractions Measured by High-Performance Liquid Chromatography: Comparison with Four Routine Methods." Clinical Chemistry 38, no. 10 (1992): 2124–29. http://dx.doi.org/10.1093/clinchem/38.10.2124.

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Abstract The effects of light on serum bilirubin subfractions in vitro were investigated by HPLC and four routine methods for bilirubin analysis. By HPLC, the rate of photodegradation of unconjugated bilirubin (Bu) was nearly twice that of monoconjugated bilirubin (mBc) and threefold that of diconjugated bilirubin (dBc); delta bilirubin (Bd) was most stable against photoirradiation. In the diazo method, the rate of photodegradation of direct bilirubin was almost the same as that of the sum of mBc, dBc, and Bd determined by the HPLC method. However, the rate of photodegradation of indirect bili

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Tetrault, G. A., B. A. Meiklejohn, and C. E. Sparks. "Clinical utility of Ektachem-determined bilirubin fractions for classifying adult inpatients." Clinical Chemistry 33, no. 9 (1987): 1662–64. http://dx.doi.org/10.1093/clinchem/33.9.1662.

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Abstract We determined total bilirubin, "direct" and "indirect" bilirubin fractions, and, in parallel, using Ektachem slides, the total, conjugated, unconjugated, and delta bilirubin contents for specimens from 88 adult inpatients at various times during hospitalization in a tertiary-care facility. We wanted to see if the results correlated with the patients' diagnoses, based on a review of medical records and other laboratory data. The patients (including some with mixed disease types) were assigned to one of three predominant disease-process groups: obstructive liver disease, parenchymal liv

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Wang, Jun, Ya-nan Xu, Long Tang, et al. "Correlation Between Serum Total Bilirubin Levels and Blood Pressure Variability in Patients With Hypertension." American Journal of Hypertension 34, no. 9 (2021): 1009–10. http://dx.doi.org/10.1093/ajh/hpab063.

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Abstract Background To investigate the effect of serum total bilirubin levels on blood pressure and its variability in patients with hypertension. Methods This study was a retrospective observational study. A total of 189 subjects were recruited from September 2019 to March 2020. All hypertensive patients were scheduled for ambulatory blood pressure and a 24-hour dynamic electrocardiography. Standard deviations of 24-hour systolic and diastolic blood pressure were used as blood pressure variability indicators. A multiple linear regression was used to analyze the relationship between total bili

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Bannerji, Rohit, Avijit Mandal, Jaydeb Ray, Monjori Mitra, SyedMd Azad, and Surupa Basu. "Correlation between transcutaneous bilirubin estimation and total serum bilirubin estimation in neonatal hyperbilirubinemia." BLDE University Journal of Health Sciences 3, no. 1 (2018): 36. http://dx.doi.org/10.4103/bjhs.bjhs_6_17.

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Wennberg, Richard P., and A. J. Hance. "Experimental Bilirubin Encephalopathy: Importance of Total Bilirubin, Protein Binding, and Blood-Brain Barrier." Pediatric Research 20, no. 8 (1986): 789–92. http://dx.doi.org/10.1203/00006450-198608000-00018.

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Al-Mendalawi, MahmoodDhahir. "Correlation between transcutaneous bilirubin estimation and total serum bilirubin estimation in neonatal hyperbilirubinemia." BLDE University Journal of Health Sciences 3, no. 2 (2018): 123. http://dx.doi.org/10.4103/bjhs.bjhs_21_18.

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Chhikara, Chetan, Vijaya Pai H, and Ganesh Pai C. "Kayser-Fleischer-like rings in patients with hepatic disease." Indian Journal of Ophthalmology 69, no. 5 (2021): 1084–87. http://dx.doi.org/10.4103/ijo.ijo_438_20.

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Purpose: The aim of this work was to study Kayser-Fleischer [KF]-like rings in patients with hepatic or cholestatic liver disease and to find out the relation between serum bilirubin level and the presence of KF like ring in these patients. Methods: In this study, we evaluated patients with hepatic and cholestatic liver diseases with total Serum bilirubin levels >10 mg/dl. These patients were evaluated for the presence or absence of KF like ring. Results: A total of 67 patients with total bilirubin >10 mg/dl were included in the study. Patients were divided into 3 groups based on total S

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Hur, Kyuhwa, and Ile-Kyu Park. "Clinical Usefulness of Direct/Total Bilirubin Ratio." Laboratory Medicine Online 8, no. 4 (2018): 127. http://dx.doi.org/10.3343/lmo.2018.8.4.127.

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