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1

อุชชิน, พรรธนมณฑน์. "ห้องปฏิบัติการอัตโนมัติ(Total Laboratory Automation: TLA)". Chulalongkorn Medical Journal 56, № 4 (2012): 399–401. http://dx.doi.org/10.58837/chula.cmj.56.4.1.

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Bailey, Adam L., Nathan Ledeboer, and Carey-Ann D. Burnham. "Clinical Microbiology Is Growing Up: The Total Laboratory Automation Revolution." Clinical Chemistry 65, no. 5 (2019): 634–43. http://dx.doi.org/10.1373/clinchem.2017.274522.

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Abstract BACKGROUND Historically, culture-based microbiology laboratory testing has relied on manual methods, and automated methods (such as those that have revolutionized clinical chemistry and hematology over the past several decades) were largely absent from the clinical microbiology laboratory. However, an increased demand for microbiology testing and standardization of sample-collection devices for microbiology culture, as well as a dwindling supply of microbiology technologists, has driven the adoption of automated methods for culture-based laboratory testing in clinical microbiology. CO
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Souverijn, John H. M. "Assay on FAQ's on Total Lab Automation." JALA: Journal of the Association for Laboratory Automation 7, no. 6 (2002): 41–46. http://dx.doi.org/10.1016/s1535-5535-04-00225-4.

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The purpose of the introduction of an automated laboratory system in one format or another is reducing the costs of the laboratory by cutting staff. Also speeding up the performance often is a goal. At the same time it is planned to increase the quality of the work done by using automated labelling and reading of documents. The use of vacuum tubes and the handling of these by the apparatus are raising the safety of the labwork. In this paper many aspects of the daily routines when using a TLA system are discussed. The aspects are collected during the discussions before and after the implementa
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Antonios, Kritikos, Antony Croxatto, and Karissa Culbreath. "Current State of Laboratory Automation in Clinical Microbiology Laboratory." Clinical Chemistry 68, no. 1 (2021): 99–114. http://dx.doi.org/10.1093/clinchem/hvab242.

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Abstract Background Although it has been 30 years since the first automation systems were introduced in the microbiology laboratory, total laboratory automation (TLA) has only recently been recognized as a valuable component of the laboratory. A growing number of publications illustrate the potential impact of automation. TLA can improve standardization, increase laboratory efficiency, increase workplace safety, and reduce long-term costs. Content This review provides a preview of the current state of automation in clinical microbiology and covers the main developments during the last years. W
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Lippi, Giuseppe, and Giorgio Da Rin. "Advantages and limitations of total laboratory automation: a personal overview." Clinical Chemistry and Laboratory Medicine (CCLM) 57, no. 6 (2019): 802–11. http://dx.doi.org/10.1515/cclm-2018-1323.

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Abstract Automation is considered one of the most important breakthroughs in the recent history of laboratory diagnostics. In a model of total laboratory automation (TLA), many analyzers performing different types of tests on different sample matrices are physically integrated as modular systems or physically connected by assembly lines. The opportunity to integrate multiple diagnostic specialties to one single track seems effective to improve efficiency, organization, standardization, quality and safety of laboratory testing, whilst also providing a significant return of investment on the lon
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Assama Riaz, Dinali Obeysekera, and Kelsie Ruslow. "Total lab automation in microbiology: An overview of BD Kiestra InoqulA and Copan WASP." Open Access Research Journal of Biology and Pharmacy 1, no. 1 (2021): 07–015. http://dx.doi.org/10.53022/oarjbp.2021.1.1.0011.

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Total Laboratory Automation (TLA) is the future of laboratory diagnostics due to its efficiency, reproducibility, better turnaround time (TATs), precision, sensitivity, and specificity. Microbiology is generally considered a human dependent field and still, most of the microbiology world is confused with TLA implementation. Two better-claimed technologies BD Kiestra InoqulA and Copan WASP have emerged as a well satisfactory solution of microbiology automation in the last decade. Here we design a practical approach and reviewed all studies of BD Kiestra InoqulA and Copan WASP, assessed microbio
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Mitchell, Kaitlin, Abby Crozier, Carey-Ann Burnham, and Melanie Yarbrough. "Processing of Positive Blood Cultures Using a Total Laboratory Automation System: Workflow and Clinical Validation." American Journal of Clinical Pathology 152, Supplement_1 (2019): S31—S32. http://dx.doi.org/10.1093/ajcp/aqz112.060.

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Abstract Automated systems for culture-based microbiology are in the early phase of implementation in clinical laboratories. Here, our objective was to evaluate the performance of the BD Kiestra Total Laboratory Automation (TLA) System for inoculation, incubation, and imaging of positive blood culture broth specimens. To optimize parameters for clinical testing, 56 clinical specimens were processed using both TLA and manual standard-of-care (SOC) methods. For TLA processing, 3 mL positive blood culture broth (35 VersaTREK: 19 aerobic, 16 anaerobic; 21 BD BACTEC: 15 aerobic, 6 anaerobic) was tr
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Aldajani, Enjod Saleh, and Bussma Ahmed Bugis. "Patient Perspectives on The Implementation of Specimen-Tracking Services Through Total Laboratory Automation In Dammam, Saudi Arabia." International Journal of Membrane Science and Technology 10, no. 3 (2023): 3353–63. http://dx.doi.org/10.15379/ijmst.v10i3.3325.

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Introduction: Total laboratory automation (TLA) is a system in which performs several diverse categories of assessments on different types of specimens. This study aims to study patient perspectives on the implementation of specimen-tracking services through TLA in Dammam. Materials and methods: The study was based on a cross-sectional research design. A self-administered questionnaire was developed, and data was collected from patients who utilized the laboratory services in Dammam from January 2022 to January 2023 and who were more than 18 years old. Results: The total number of 283 response
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Kritikos, Antonios, Guy Prod’hom, Damien Jacot, Antony Croxatto, and Gilbert Greub. "The Impact of Laboratory Automation on the Time to Urine Microbiological Results: A Five-Year Retrospective Study." Diagnostics 14, no. 13 (2024): 1392. http://dx.doi.org/10.3390/diagnostics14131392.

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Total laboratory automation (TLA) is a valuable component of microbiology laboratories and a growing number of publications suggest the potential impact of automation in terms of analysis standardization, streaking quality, and the turnaround time (TAT). The aim of this project was to perform a detailed investigation of the impact of TLA on the workflow of commonly treated specimens such as urine. This is a retrospective observational study comparing two time periods (pre TLA versus post TLA) for urine specimen culture processing. A total of 35,864 urine specimens were plated during the pre-TL
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Roundy, Caleb S., David C. Lin, Paul J. Klopping, Ammon T. Ence, Anthony C. Krezel, and Jonathan R. Genzen. "Specimen Temperature Detection on a Clinical Laboratory Pre-Analytic Automation Track: Implications for Direct-from-Track Total Laboratory Automation (TLA) Systems." SLAS TECHNOLOGY: Translating Life Sciences Innovation 25, no. 3 (2019): 293–99. http://dx.doi.org/10.1177/2472630319881999.

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Clinical laboratory regulations require temperature monitoring of facilities, reagent and specimen storage, as well as temperature-dependent equipment. Real-time specimen temperature detection has not yet been integrated into total laboratory automation (TLA) solutions. An infrared (IR) pyrometer was paired with a complementary metal oxide semiconductor (CMOS) laser sensor and connected to an embedded networked personal computer (PC) to create a modular temperature detection unit for closed, moving clinical laboratory specimens. Accuracy of the detector was assessed by comparing temperature me
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Bryan, Andrew, Linda Cook, Ederlyn E. Atienza, et al. "Bloodborne Viral Pathogen Contamination in the Era of Laboratory Automation." Clinical Chemistry 62, no. 7 (2016): 973–81. http://dx.doi.org/10.1373/clinchem.2016.255349.

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Abstract BACKGROUND The CDC states that laboratory testing for persons under investigation for Ebola virus disease can be safely performed using automated laboratory instruments by adhering to bloodborne pathogen practices. We therefore sought to investigate the levels of viral contamination of a total laboratory automation (TLA) system to guide risk mitigation strategies for handling infectious agents. METHODS Environmental swabs followed by PCR for hepatitis B (HBV) and hepatitis C (HCV) viruses were taken from a chemistry TLA system during routine clinical use and after running a small numb
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Graves, Sean, Bill Holman, and Robin A. Felder. "Modular Robotic Workcell for Coagulation Analysis." Clinical Chemistry 46, no. 5 (2000): 772–77. http://dx.doi.org/10.1093/clinchem/46.5.772.

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Abstract Background: Total laboratory automation (TLA) has been shown to increase laboratory efficiency and quality. However, modular automation is smaller, requires less initial capital, and requires less planning than TLA. We engineered and performed clinical trials on a modular robotic preanalytical workcell for coagulation analysis. Methods: Timing studies were used to quantify the efficiency of the manual processes and to identify areas in the processing of coagulation specimens where bottlenecks and long waiting periods were encountered. We then designed our modular robotic system to eli
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Emmalyn, B. Cutamora, C. Cortes Kenneth, and Andrew Pepito Joseph. "Are Medical Technologists still needed in Medical Laboratories in a Technologically Advanced Future?" Journal of Health and Medical Sciences 5, no. 3 (2022): 56–65. https://doi.org/10.31014/aior.1994.05.03.230.

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An emerging trend in modern medical laboratories is automation, and it is having a positive impact on the quality of service to patients and on the safety of medical laboratory staff. The use of automation in medical laboratories enable many tests by analytical instruments with minimal use of an analyst. These automated instruments result in increasing the capabilities of a laboratory to process more workload with minimum involvement of manpower. Total Laboratory Automation (TLA) has many advantages including workload reduction, less time spent per sample, increased number of tests done in les
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Ayesha, Aftab, Fabha Ali Syeda, Saad Bin Najeeb Shah, et al. "Total Laboratory Automation System in Clinical Biochemistry: Efficient Turnaround Time (TAT) with Prompt, Accurate, Quality Assured Reports for Sustainable Patient Care of Accident and Emergency Department-At a Tertiary Care Hospital." Chemistry Research Journal 8, no. 6 (2023): 114–18. https://doi.org/10.5281/zenodo.11391044.

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<strong>Abstract </strong> <strong>Objective:</strong> To compare and assess benefits of Total Laboratory Automation and its impact on Turnaround Time for Accident and Emergency Department requested chemistry and liver function profile tests. <strong>Materials and Methods</strong>: It&rsquo;s an observational study based on efficiency of Total lab automation with integrated system of Cobas p471, p512, e801, c503 and p501 in clinical chemistry work flow and achievable targeted TAT of AED requested chemistry profile tests viz, urea, creatinine, electrolytes (tagged as Profile UCE), and Liver fun
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Acero, Raquel, Marta Torralba, Emilio-David Valverde, Lourdes Roc, and Antonio Rezusta. "Integrating Lean and Automation for Enhanced Serology Diagnosis Efficiency in Tertiary Healthcare Microbiology Laboratories." Applied Sciences 14, no. 1 (2023): 241. http://dx.doi.org/10.3390/app14010241.

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Healthcare services and institutions are focused on providing the most appropriate medical service in terms of patient safety and satisfaction outcomes. According to Lean methodologies, effectiveness and efficiency can be improved by assuring value-added processes. This article presents a joint approach for the development and implementation of Lean techniques combined with Total Laboratory Automation (TLA) for serology diagnosis in a microbiology laboratory in a tertiary-level hospital. The results obtained show an improvement in the process efficiency and its key performance indicators. In p
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Ishrat, Sultana, Sardar Afsheen, Mahmood Alam Junaid, Shamim Anwer Afshan, Waseem Jafferi Syed, and Ameen Mehwish. "Comparative precision analysis of six enzymatic parameters from both normal and diseased individuals on two separate standalone Cobas c501 and TLA modular CCM Cobas c503 instruments." Chemistry Research Journal 8, no. 3 (2023): 52–55. https://doi.org/10.5281/zenodo.11304500.

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<strong>Abstract </strong>Analytical precisions, accuracy and standardization are now mandatory requirements for a clinical laboratory for sustainable patient care and good standing. Present study described comparative precision analysis of six enzymatic parameters from both normal and diseased individuals on two separate standalone Cobas c501 and TLA modular CCM Cobas c503 instruments. Blood was collected from fifty (n = 50), healthy individuals, as well as fifty (n = 50) from confirmed cases of hepatic, muscular and cardiac patients, twenty five each from either gender (males or female). Pla
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Patel, Parul, Lauren E. Droske, Jignesh Patel, Ruby Barza, Rebecca Lindgren, and Erin McElvania. "2152. Detection of Uropathogens Using BD Kiestra™ Total Laboratory Automation with Urine Culture Application." Open Forum Infectious Diseases 6, Supplement_2 (2019): S730. http://dx.doi.org/10.1093/ofid/ofz360.1832.

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Abstract Background Urine is the most frequently cultured specimen type for the majority of clinical microbiology laboratories. Typically, around 30% of cultures are positive for uropathogens with 70% yielding insignificant or mixed growth. BD is developing a software Urine Culture Application (UCA) for the BD Kiestra Total Laboratory Automation (TLA) system to screen images of urine culture plates, sort them based on growth vs. insignificant growth and also allow for presumptive pathogen identification. Methods De-identified urine specimens were inoculated onto BD BBL™ CHROMagar™ Orientation
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Xiao, Lei. "Designing and implementing a large-scale high-throughput Total Laboratory Automation (TLA) system for DNA database construction." Forensic Science International 302 (September 2019): 109859. http://dx.doi.org/10.1016/j.forsciint.2019.06.017.

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Pasqualetti, Sara, Assunta Carnevale, Alberto Dolci, and Mauro Panteghini. "A step towards optimal efficiency of HbA1c measurement as a first-line laboratory test: the TOP-HOLE (Towards OPtimal glycoHemOgLobin tEsting) project." Clinical Chemistry and Laboratory Medicine (CCLM) 60, no. 3 (2022): 441–50. http://dx.doi.org/10.1515/cclm-2021-1249.

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Abstract Objectives The TOP-HOLE (Towards OPtimal glycoHemOgLobin tEsting) project aimed to validate the HbA1c enzymatic method on the Abbott Alinity c platform and to implement the HbA1c testing process on the total laboratory automation (TLA) system of our institution. Methods Three different measuring systems were employed: Architect c4000 stand-alone (s-a), Alinity c s-a, and Alinity c TLA. Eight frozen whole blood samples, IFCC value-assigned, were used for checking trueness. A comparison study testing transferability of HbA1c results from Architect to Alinity was also performed. The alig
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Baste, Charisse Liz, David M. Loeffler, Carmen Brana-Mulero, Archana Shah, and Ming Jin. "Hepatitis Testing Performance of an Analyzer Integrated into Another Manufacturer’s Automation System." Journal of Applied Laboratory Medicine 5, no. 4 (2020): 716–23. http://dx.doi.org/10.1093/jalm/jfaa034.

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Abstract Background The capacity to integrate platforms across vendors and disciplines has become an essential feature in the design of total laboratory automation (TLA) due space and test menu constraints. However, data on its performance are lacking. We aim to evaluate an integrated third-party immunoassay platform to the TLA system for the performance of hepatitis testing using turnaround time (TAT). Methods We use the Beckman Power Express (PE) system with linked 2 Beckman AU5800, 2 Beckman DxI 800, 2 Abbott Architect i2000, and other accessory components. The PE system is managed and inte
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Farooq, Nouman, Alanna Emrick, Carolyn Gonzalez-Ortiz, et al. "2161. Organism-Specific Turn Around Time Improvement in Urinary Specimens as a Result of Microbiological Laboratory Automation." Open Forum Infectious Diseases 6, Supplement_2 (2019): S733. http://dx.doi.org/10.1093/ofid/ofz360.1841.

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Abstract Background University Medical Center in Lubbock, TX is one of few medical centers using Becton Dickinson (BD) Kiestra Total Laboratory Automation (TLA) system since May 2015. The impact on organism-specific turn around time (TAT) in urinary specimens after implementation of TLA was evaluated. Methods After approval from the Quality Improvement Review Board, a retrospective analysis of microbiological data from urinary specimens in BD research database was performed. Before vs. after implementation (2013 vs. 2016) TAT was compared. Ten clinically relevant organisms were analyzed. Stati
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Ishrat, Sultana, Sardar Afsheen, Ali Humaira, Mahmood Alam Junaid, Noureen Shazia, and Ameen Mehwish. "Comparative precision analysis of urinary micro-albumin of female diabetic patients with underlying clinical conditions on Standalone Cobas c501 and CCM Cobas Total Lab Automation c503." Chemistry Research Journal 8, no. 3 (2023): 56–59. https://doi.org/10.5281/zenodo.11304567.

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<strong>Abstract </strong>Elevated levels of urinary micro-albumin indicates proceeding cardiovascular and renal anomalies and should be treated immediately. Timely reporting of such an important biomarker, with precision and accuracy must and should be a priority of any clinical laboratory. Aim of present study is to analyze precision and accuracy of newly installed total lab automation system CCM c503 analyzer with existing standalone Cobas c501 and vice versa using urinary micro-albumin as test material. Samples from diagnosed female patients of hypertension (n = 35), renal disease (n = 40)
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Yadav, Anurag, Ramlingareddy, Avinash SS, and Malathi M. "“A ROBUST METHOD FOR REDUCING SAMPLE RETRIEVAL TAT IN CLINICAL LABORATORY SETUP AT ZERO ADDED INVESTMENT.”." International Journal of Medical Laboratory Research 07, no. 02 (2022): 12–17. http://dx.doi.org/10.35503/ijmlr.2022.7203.

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Background: The concept of Total Laboratory Automation (TLA) is shifting towards the automation in individual process i.e., Task Targeted automation (TTA). Sample storage is one of the key areas in the Total Testing Process (TTP), hence we developed a robust method to reduce the TAT for blood sample retrieval in clinical biochemistry laboratory with zero added investment. We compared the sample retrieval time (TAT) improvement in sample retrieval with the old conventional and the new method of sample storage. Material and method: study was conducted at a medium-large scale lab with average sam
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Damaševičius, Robertas, Rytis Maskeliūnas, Gintautas Narvydas, Rūta Narbutaitė, Dawid Połap, and Marcin Woźniak. "Intelligent automation of dental material analysis using robotic arm with Jerk optimized trajectory." Journal of Ambient Intelligence and Humanized Computing 11, no. 12 (2020): 6223–34. http://dx.doi.org/10.1007/s12652-020-02605-8.

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AbstractMany types of biomaterial analysis require numerous repetition of the same operations. We suggest applying the principles of Total Laboratory Automation (TLA) for analysis of dental tissues in in-vitro conditions. We propose an innovative robotic platform with ABB high precision industrial robotic arm. We programmed the robot to achieve 3000 cycles of submerging for analysis of the stability and thermal wear of dental adhesive materials. We address the problem of robot trajectory planning to achieve smooth and precise trajectory while minimizing jerk. We generate different variants of
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Jasuja, Jasmin Kaur, Stefan Zimmermann, and Irene Burckhardt. "Applicability and performance of EUCAST’s rapid antimicrobial susceptibility testing (RAST) on primarily sterile body fluids in blood culture bottles in laboratory routine with total lab automation." European Journal of Clinical Microbiology & Infectious Diseases 40, no. 6 (2021): 1217–25. http://dx.doi.org/10.1007/s10096-020-04146-6.

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AbstractOptimisation of microbiological diagnostics in primarily sterile body fluids is required. Our objective was to apply EUCAST’s RAST on primarily sterile body fluids in blood culture bottles with total lab automation (TLA) and to compare results to our reference method Vitek2 in order to report susceptibility results earlier. Positive blood culture bottles (BACTEC™ Aerobic/Anaerobic/PEDS) inoculated with primarily sterile body fluids were semi-automatically subcultured onto Columbia 5% SB agar, chocolate agar, MacConkey agar, Schaedler/KV agar and Mueller-Hinton agar. On latter, cefoxiti
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Thomson, Richard B., and Erin McElvania. "Total Laboratory Automation." Clinics in Laboratory Medicine 39, no. 3 (2019): 371–89. http://dx.doi.org/10.1016/j.cll.2019.05.002.

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Brown, Megan, Jennifer Colby, Matthew Feldhammer, and James Nichols. "Automated Clinical Chemistry Platform Performance Across Two Academic Medical Centers." American Journal of Clinical Pathology 152, Supplement_1 (2019): S24. http://dx.doi.org/10.1093/ajcp/aqz112.046.

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Abstract Our objective was to define the performance of automated chemistry platforms at two large academic medical centers by calculating and comparing sigma metrics for 28 analytes. Performance characteristics of chemistry assays on two Roche Cobas analyzers and four Abbott Architect analyzers were estimated using 12 months of Bio-Rad quality control (QC) data at two concentrations. Method imprecision was calculated as the cumulative QC coefficient of variation (CV) across analyzers at each QC concentration and percent bias was calculated by comparison of analyzer QC mean to peer group means
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嶋田, 好宏, and 敬児 阿南. "A Plan of Structuring Total Laboratory Automation (Laboratory Automation System )." JAPANES JOURNAL OF MEDICAL INSTRUMENTATION 67, no. 12 (1997): 591–96. http://dx.doi.org/10.4286/ikakikaigaku.67.12_591.

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Yu, Hoi-Ying Elsie, Harold Lanzoni, Tracy Steffen, et al. "Improving Laboratory Processes with Total Laboratory Automation." Laboratory Medicine 50, no. 1 (2018): 96–102. http://dx.doi.org/10.1093/labmed/lmy031.

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Sasaki, Masahide, Takeshi Kageoka, Katsumi Ogura, Hiromi Kataoka, Tadashi Ueta, and Shigeyoshi Sugihara. "Total laboratory automation in Japan." Clinica Chimica Acta 278, no. 2 (1998): 217–27. http://dx.doi.org/10.1016/s0009-8981(98)00148-x.

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Hawker, Charles D. "Laboratory Automation: Total and Subtotal." Clinics in Laboratory Medicine 27, no. 4 (2007): 749–70. http://dx.doi.org/10.1016/j.cll.2007.07.010.

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Palutke, Margarita. "Total Hematology Automation." Laboratory Automation News 1, no. 6 (1996): 8–13. http://dx.doi.org/10.1177/221106829600100602.

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Hitachi and Sysmex corporations combined their efforts to produce an integrated, high through-put laboratory by combining various sections of hematology and chemistry requiring a small fraction of the number of personnel employed.
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Tomar, Russell. "Total Laboratory Automation and Diagnostic Immunology." Clinical Diagnostic Laboratory Immunology 6, no. 3 (1999): 293–94. http://dx.doi.org/10.1128/cdli.6.3.293-294.1999.

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Ialongo, Cristiano, Ottavia Porzio, Ilio Giambini, and Sergio Bernardini. "Total Automation for the Core Laboratory." Journal of Laboratory Automation 21, no. 3 (2016): 451–58. http://dx.doi.org/10.1177/2211068215581488.

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Lamb, Dennis A. "Total Laboratory Automation - The Planning Process." Laboratory Automation News 2, no. 6 (1997): 57–60. http://dx.doi.org/10.1177/221106829700200612.

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BENGHEZEL, Hichem, and Mounir SADELAOUD. "Total automation of medical biology laboratories." Batna Journal of Medical Sciences (BJMS) 11, no. 1 (2024): 31–38. http://dx.doi.org/10.48087/bjmsra.2024.11106.

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This literature review provides a detailed examination of the preanalytical, analytical, and postanalytical tasks that can be automated within the operations of a medical biology laboratory. We conduct an in-depth analysis of the various components of automation, making precise distinctions between no automation, partial automation, and full automation. The objectives and expectations associated with full automation will be discussed, while identifying the limitations and challenges inherent in it. In conclusion, we present prospects for automation in this vital area of medicine, highlighting
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Brunner, Linda A. "The laboratory of the 1990s—Planning for Total Automation." Journal of Automatic Chemistry 14, no. 2 (1992): 43–45. http://dx.doi.org/10.1155/s1463924692000105.

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The analytical laboratory of the 1990s must be able to meet and accommodate the rapid evolution of modern-day technology. One such area is laboratory automation. Total automation may be seen as the coupling of computerized sample tracking, electronic documentation and data reduction with automated sample handling, preparation and analysis, resulting in a complete analytical procedure with minimal human involvement. Requirements may vary from one laboratory or facility to another, so the automation has to be flexible enough to cover a wide range of applications, and yet fit into specific niches
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Da Rin, Giorgio, and Giuseppe Lippi. "Total Laboratory Automation of Routine Hemostasis Testing." Journal of Laboratory Automation 19, no. 4 (2014): 419–22. http://dx.doi.org/10.1177/2211068213511246.

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Salvagno, Gian Luca, Elisa Danese, and Giuseppe Lippi. "Mass spectrometry and total laboratory automation: opportunities and drawbacks." Clinical Chemistry and Laboratory Medicine (CCLM) 58, no. 6 (2020): 994–1001. http://dx.doi.org/10.1515/cclm-2019-0723.

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AbstractThe diffusion of laboratory automation, initiated nearly 50 years ago with consolidation of preanalytical, clinical chemistry and immunochemistry workstations, is now also gradually embracing mass spectrometry (MS). As for other diagnostic disciplines, the automation of MS carries many advantages, such as efficient personnel management (i.e. improving working atmosphere by decreasing manual activities, lowering health risks, simplifying staff training), better organization (i.e. reducing workloads, improving inventory handling, increasing analytical process standardization) and the pos
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Lee, Y. "Considerations of valuable technologies for total laboratory automation." Clinica Chimica Acta 530 (May 2022): S460—S461. http://dx.doi.org/10.1016/j.cca.2022.04.786.

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Genzen, Jonathan R., Carey-Ann D. Burnham, Robin A. Felder, Charles D. Hawker, Giuseppe Lippi, and Octavia M. Peck Palmer. "Challenges and Opportunities in Implementing Total Laboratory Automation." Clinical Chemistry 64, no. 2 (2018): 259–64. http://dx.doi.org/10.1373/clinchem.2017.274068.

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Adler, Jakob, and Georg Hoffmann. "Total Laboratory Automation: Vom „AutoAnalyzer“ zum Labor 4.0." Trillium Diagnostik 22, no. 5 (2024): 6–9. http://dx.doi.org/10.47184/td.2024.05.01.

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Die Welt wandelt sich. Waren bisher die Ingenieursdisziplinen in der führenden Rolle, so sind es im 21. Jahrhundert die Software-Unternehmen, die den Ton angeben. Diese Entwicklung spielt auch bei der Automation im medizinischen Labor eine entscheidende Rolle. Während die Hardware-Automationslösungen der unterschiedlichen Hersteller relativ vergleichbar arbeiten, unterscheiden sich die Softwarelösungen für das Labor (LIS, Middleware etc.) mitunter erheblich. Kann mehr und bessere Software einen Beitrag zur Linderung des Fachkräftemangels leisten?
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Dolci, Alberto, Davide Giavarina, Sara Pasqualetti, Dominika Szőke, and Mauro Panteghini. "Total laboratory automation: Do stat tests still matter?" Clinical Biochemistry 50, no. 10-11 (2017): 605–11. http://dx.doi.org/10.1016/j.clinbiochem.2017.04.002.

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44

Seaberg, Richard S., Robert O. Stallone, and Bernard E. Statland. "The Role of Total Laboratory Automation in a Consolidated Laboratory Network." Clinical Chemistry 46, no. 5 (2000): 751–56. http://dx.doi.org/10.1093/clinchem/46.5.751.

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Abstract Background: In an effort to reduce overall laboratory costs and improve overall laboratory efficiencies at all of its network hospitals, the North Shore–Long Island Health System recently established a Consolidated Laboratory Network with a Core Laboratory at its center. Methods: We established and implemented a centralized Core Laboratory designed around the Roche/Hitachi CLAS Total Laboratory Automation system to perform the general and esoteric laboratory testing throughout the system in a timely and cost-effective fashion. All remaining STAT testing will be performed within the Ra
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45

Hawker, Charles D., and Marc R. Schlank. "Development of Standards for Laboratory Automation." Clinical Chemistry 46, no. 5 (2000): 746–50. http://dx.doi.org/10.1093/clinchem/46.5.746.

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Abstract In clinical laboratories, the installation of total laboratory automation systems and/or modular systems has grown dramatically in the 1990s, particularly in the US, Japan, and Europe. As the number of installations and level of interest grew, several individuals and corporations active in the automation field recognized that the development of prospective standards might enable customers of such systems or equipment to purchase analyzers, automation systems or devices, and software from different vendors and retain interconnectivity of such equipment. These individuals also believed
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46

Bakan, Ebubekir, and Nuri Bakan. "Prevention of extra-analytical phase errors by non-analytical automation in clinical laboratory." Turkish Journal of Biochemistry 46, no. 3 (2021): 235–43. http://dx.doi.org/10.1515/tjb-2020-0483.

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Abstract During previous decades, significant improvements in laboratory errors have become a substantial part of reducing preventable diagnostic errors. In clinical laboratory practice, the errors in the testing process are primarily associated with extra-analytical phase error sources, influencing the test result quality profoundly. Thus, the management of these critical error sources makes their effects preventable thanks to automation and computer sciences. The implementation of non-analytical automated systems requires a risk management strategy based on laboratory’s workflow and bottlene
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47

Vercruysse, Kobe, Stijn Lambrecht, and Matthijs Oyaert. "Total lab automation: sample stability of clinical chemistry parameters in an automated storage and retrieval module." Clinical Chemistry and Laboratory Medicine (CCLM) 60, no. 1 (2021): 52–59. http://dx.doi.org/10.1515/cclm-2021-0866.

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Abstract Objectives Automated storage and retrieval modules (SRM), as part of total lab automation (TLA) systems, offer tremendous practical and economic benefits. In contrast to manual storage systems, SRMs indicate continuous motion of samples and may leave samples prone to temperature fluctuations. This study investigates analyte stability in serum and heparin plasma within an automated storage module. Methods The stability of 28 common biochemistry analytes was investigated using 57 freshly obtained routine serum samples and 42 lithium-heparin plasma samples. Following baseline measurement
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Méndez, A., S. Brunner-Agten, and A. R. Huber. "Automation in haemostasis." Hämostaseologie 33, no. 04 (2013): 295–98. http://dx.doi.org/10.5482/hamo-12-05-0002.

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SummaryAutomatia, an ancient Greece goddess of luck who makes things happen by themselves and on her own will without human engagement, is present in our daily life in the medical laboratory. Automation has been introduced and perfected by clinical chemistry and since then expanded into other fields such as haematology, immunology, molecular biology and also coagulation testing. The initial small and relatively simple standalone instruments have been replaced by more complex systems that allow for multitasking. Integration of automated coagulation testing into total laboratory automation has b
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Zu, Yunqin, Siqi Li, Qijia Liu, and Lixun Zhang. "Real-time and accurate detection in total laboratory automation." Computers and Electrical Engineering 122 (March 2025): 110016. https://doi.org/10.1016/j.compeleceng.2024.110016.

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50

Markin, Rodney S., and Scott A. Whalen. "Laboratory Automation: Trajectory, Technology, and Tactics." Clinical Chemistry 46, no. 5 (2000): 764–71. http://dx.doi.org/10.1093/clinchem/46.5.764.

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Abstract Laboratory automation is in its infancy, following a path parallel to the development of laboratory information systems in the late 1970s and early 1980s. Changes on the horizon in healthcare and clinical laboratory service that affect the delivery of laboratory results include the increasing age of the population in North America, the implementation of the Balanced Budget Act (1997), and the creation of disease management companies. Major technology drivers include outcomes optimization and phenotypically targeted drugs. Constant cost pressures in the clinical laboratory have forced
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