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Al-Naimy, Ebtehal H., Ruqaya M. Al-Ezy, Maysaa C. Al-Yas, and Muthanna A. S. Al- Mahdawii. "Immunomodulation of mice blood cells following treatment with free extract of Lactobacillus acidophilus cell." Journal of Biotechnology Research Center 4, no. 2 (2010): 98–107. http://dx.doi.org/10.24126/jobrc.2010.4.2.134.
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A study aimed to examine immunomodulatory effect of concentrated cell free filtrate (CCF) of Lactobacillus acidophilus on immune system of mice by detecting the total and absolute counts of leucocytes. It was shown that CCF of Lactobacillus acidophilus caused a significant increase in total leucocyte count for all concentrations used in comparison with negative control. However, in absolute leucocyte counts the, CCF of L.acidophilus at doses (500 , 750) mg/kg caused a significant increased in lymphocyte, neutrophil and monocyte counts, while there was no significant differences in eosinophils and basophil cells number of mice treated with bacterial filtrate. The interaction study showed that the post-treatment with CCF of L. acidophilus caused a significant increase in total leucocytes count and absolute counts of all types of leucocyte cells except basophils and esinophils which showed no significant differences in comparison with pre-treatment
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A. Joshi, Anagha, Gayathri B. R., and Yashica Gowda R. "The total leucocyte count: its utility in dengue." International Journal of Advances in Medicine 4, no. 6 (2017): 1621. http://dx.doi.org/10.18203/2349-3933.ijam20175178.
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Background: Dengue infections are public health concerns in India, where they occur in epidemics and have a high mortality in the advanced stages. Clinical features are nonspecific, and diagnosis is supported by lab features. One of these lab tests include total leucocyte count-easily available, simple and cost effective which is useful in small rural set ups for early diagnosis and prognosis of dengue. The aim of this study is to analyse the total leucocyte count patterns in dengue and assess its utility as early marker of dengue and prognosticator of severe dengue.Methods: A total of 132 serologically proven cases of dengue with total white cell counts (blood counts obtained by Automated hematology analyser) during November 2016 were analysed.Results: In our study, most cases were noted in the younger age group with a male predominance. The range of total leucocyte count was 1.1x109 /l to 14.3x109/l. Most (55%) had normal counts, leucopenia was noted in 36%, had an equal distribution in all ages and both sexes. 82% had mild leucopenia,52% of leucopenia cases were associated with severe thrombocytopenia. Almost half (47%) of leucopenia cases were NS1 positive while only 15% were antibody positive.59% of NS1 positive had leucopenia in contrast to 13% of antibody positive cases. While leucopenia was mostly (55%) associated with neutrophilia, lymphocytosis was seen in 74% of cases with a normal leucocyte count.Conclusions: Total leucocyte count is one of the simple, easily available, cost effective tests useful in small rural set ups for early diagnosis and prognosis in dengue and helps reduce the morbidity and mortality of dengue.
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Sultana, Safia, Nabila Afsar, Mohammed Jawad, and Mohammed Abdul Hannan Hazari. "Effects of cigarette smoking on erythrocyte sedimentation rate, platelet count, total and differential leucocyte counts in adult male smokers." Annals of Medical Physiology 3, no. 1 (2019): 14–18. https://doi.org/10.23921/amp.2019v3i1.35185.
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Smoking is one of the leading causes of death worldwide. Smokers have higher risk for coronary heart disease, atherosclerosis, acute myocardial infarction, hypertension, clotting disorders, inflammation, respiratory diseases, cancers, etc. A cigarette smoker is exposed to a number of harmful substances. In this study we hypothesized that smoking causes inflammatory reactions and induces hyperthrombic state in the body which may be reflected in erythrocyte sedimentation rate (ESR), total leucocyte count (TLC), differential leucocyte count (DLC) and platelet count values. The purpose of the study was to study the effects of cigarette smoking on erythrocyte sedimentation rate, total leucocyte count and platelet count in adult male smokers and to compare the results with non-smokers and to establish a relationship between the duration and quantity of smoking with the change in ESR, TLC, DLC and platelet count. A cross sectional study was conducted in the department of Pathology on 86 healthy male subjects (smokers=43 and non-smokers=43). ESR was estimated using Westergrens method. TLC, DLC and platelet counts were estimated using HORIBA Pentra ES60 autoanalyser. TLC and basophil counts were significantly higher in smokers than in non-smokers (p<0.05). The mean value of ESR was higher among smokers than non-smokers but it was statistically insignificant. Platelets counts showed no significant difference between smokers and non- smokers. No correlation was observed in various blood parameters and smoking (in pack years). We conclude that smoking initiates an inflammatory response as evidenced from raised TLC, monocyte and basophil counts.
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Kumar, Amit, Kusum Kumari, Priyanki ., and Pranay Kumar Mishra. "A study to assess the therapeutic role of GM-CSF (EMGRAST -M) on augmentation of total leucocyte count and total platelet count in cancer patients after chemotherapy." International Journal of Basic & Clinical Pharmacology 7, no. 9 (2018): 1803. http://dx.doi.org/10.18203/2319-2003.ijbcp20183493.
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Background: The aim of the present study was to assess the therapeutic role of GM-CSF (EMGRAST -M) on augmentation of total leucocyte count and total platelet count in cancer patients after chemotherapy.Methods: The total leucocyte count (TLC) and total platelet count (TPC) of thirty patients on chemotherapy were obtained before and after the administration of GM-CSF. The results were analysed retrospectively for the effect of GM-CSF on these parameters. Statistical analysis was done, and graphs were made by Libre office calc and Student’s T Test was used for comparison of data.Results: The study showed that EMGRAST-M had an impressive effect on both the platelet count and the leucocyte count.Conclusions: GM-CSF has a great therapeutic role in the enhancement of platelet count and leucocyte count in patients of cancer chemotherapy.
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Zeeshan Shoukat, Muhammad Saeed Awan, Talha Makshoof, Mujahid Zulfiqar, Sohail Ilyas, and Muhammad Zubair. "Association of Total Leucocyte Count and Acute Appendicitis Among Young Patients Undergoing Emergency Appendectomy." Pakistan Armed Forces Medical Journal 73, no. 5 (2023): 1205–8. http://dx.doi.org/10.51253/pafmj.v73i5.7825.
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Objective: To study the association of total leucocyte count and acute appendicitis among young patients undergoing emergency appendectomy. Study Design: Comparative cross-sectional study. Place and Duration of Study: Department of Surgery, Combined Military Hospital, Quetta Pakistan, from Mar to Oct 2021. Methodology: The study included one hundred patients diagnosed with acute appendicitis by a consultant surgeon undergoing an emergency appendectomy. The total leucocyte count was calculated for all the patients at the time of diagnosis. The treating surgeon confirmed acute appendicitis findings based on gross examination of the appendix at the time of surgery. The presence of acute appendicitis and other factors was associated with raised total leucocyte count in all the patients. Results: Out of 100 patients diagnosed with acute appendicitis, 59 were male, while 41 were female. The mean age of the study participants was 28.33±3.673 years. On gross examination, 79 had a confirmed diagnosis of acute appendicitis, while 21 did not have an inflamed appendix. 85 had raised total leucocyte count, while 15 patients had total leucocyte count in the normal range. Statistical analysis revealed that acute appendicitis on gross examination and raised C-reactive protein had a statistically significant correlation with raised total leucocyte count (p-value: 0.001). Conclusion: Total leucocyte count was significantly raised in patients who had confirmation of inflammation of the appendix at gross examination during the surgery. Raised total leucocyte count and C reactive protein should be given more weightage in diagnosing acute appendicitis and planning for an emergency appendectomy.
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Ava, Dihingia, and Jahan Wasima. "A Study Of The Hematological Profile In Relation To Some Allergic Diseases (A Hospital Based Study)." International Journal of Basic and Applied Physiology 2, no. 1 (2013): 35–40. https://doi.org/10.5281/zenodo.4478485.
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Eosinophils and neutrophils play major roles in pathogenesis of allergy.However the relation between peripheral blood cell counts of other major leukocyte groups, Hb%, ESR in allergic diseases is less clear.Therefore this study was conducted to find out if there is any variation in the haematological profile in subjects having allergic disease. Method: 50 cases of bronchial asthma, 50 cases of some allergic skin disorders and 50 cases of allergic rhinitis and 50 controls were chosen for this study. The study design was cross-sectional. Total Leucocyte Count, Absolute Eosinophil Count were done using Neubauer’s chamber, Differential Leucocyte Count by Leishman’s staining and Erythrocyte Sedimentation Rate using Westergren’s method. Haemoglobin estimation was done by cyanmethaemoglobin method. The statistical analysis was done using one way analysis of variance (ANOVA) followed by t test. Result: The results showed a significant increase (p<0.05) in the Total Leucocyte Count, Absolute Eosinophil Count, Erythrocyte Sedimentation Rate and the differential counts of neutrophil and eosinophil, and a significant decrease (p<0.05) in the lymphocyte count among the cases as compared to the controls. Conclusion: It is seen that in allergic condition besides an increase in the eosinophil count, other haematological parameters also change.
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Ladyani, Festy, and Nur Fitria Dewi. "DIFFERENCES IN LEUKOCYTE RATE BETWEEN ACUTE NONPERFORATED AND PERFORATED APPENDICITIS IN HOSPITALISED PATIENTS BANDAR LAMPUNG-INDONESIA." Malahayati International Journal of Nursing and Health Science 2, no. 1 (2019): 25–31. http://dx.doi.org/10.33024/minh.v2i1.1058.
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Background: Acute appendicitis is one of the most common acute abdominal pain. A late check up and diagnosis could bring harms which is turning into perforated appendicitis. Leukocyte count is a laboratory collation that is generous and quick to diagnose the acute apendicitis and perforated appendicitis, however there’s no certain limit of the leukocytes count to recognize whether it is acute apendicitis or perforated appendicitis.Purpose: This research was to find out the comparison of leucocyte count average between acute appendicitis and perforation appendicitis in Dr. H. Abdul Moeleok public hospital of Lampung province in 2014-2016.Methods: An analytic research with cross sectional approach. Population was 382 patients with appendicitis in Dr. Hi. Abdul Moeloek public hospital. Samples were taken using total sampling technique with 196 respondent samples for acute appendicitis and 196 respondent samples for perforation appendicitis. Data were analyzed by using univariate analysis with percentage and bivariate analysis with t-test.Results: the average of leucocyte count of acute appendicitis patients was 10,907 with minimum and maximum leucocyte count of 5,000 and 18,500 respectively. The average of leucocyte count of perforation appendicitis patients was 22,789 with minimum and maximum leucocyte count of 16,500 and 31,000 respectively. There were differences of leucocyte counts between acute appendicitis patients and perforation appendicitis patients with p-value < 0.05.Conclusion: there were significant differences of leucocyte count averages between acute appendicitis and perforation appendicitis.
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Lowe-Jinde, L. "Hematological changes in Cryptobia-infected rainbow trout (Salmo gairdneri)." Canadian Journal of Zoology 64, no. 6 (1986): 1352–55. http://dx.doi.org/10.1139/z86-201.
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Rainbow trout, Salmo gairdneri, were experimentally infected with Cryptobia salmositica and total and differential erythrocyte and leucocyte abundances were examined. Total erythrocyte counts were profoundly reduced and were lowest at 4 weeks postinoculation during the peak of infection. Differential erythrocyte number showed significant reduction in mature erythrocytes, degenerating erythrocytes, and erythroblasts. The reduction in mature erythrocytes number was observed from 3 through 8 weeks postinoculation, while erythroblast reduction occurred at 1 through 5 weeks postinoculation. Subsequently, the number of erythroblasts increase and reach control values at 6, 7, and 8 weeks postinoculation. Although the total leucocyte count was not significantly changed, the differential leucocyte abundance showed that granulocytes were significantly increased. Similarly, the rarely seen, circulating, immature granuloblasts were increased. Both granuloblast and granulocyte numbers returned to control values by 8 weeks postinoculation. Thus, the pattern of differential erythrocytic and leucocytic changes reflect an acute parasitemia and a subsequent partial recovery of the infected fish to the parasitemia.
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Sultana, Safia, Nabila Afsar, Mohammed Jawad, and Mohammed Abdul Hannan Hazari. "Effects of cigarette smoking on erythrocyte sedimentation rate, platelet count, total and differential leucocyte counts in adult male smokers." Annals of Medical Physiology 3, no. 1 (2019): 14–18. http://dx.doi.org/10.23921/amp.2019v3i1.35185.
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Smoking is one of the leading causes of death worldwide. Smokers have higher risk for coronary heart disease, atherosclerosis, acute myocardial infarction, hypertension, clotting disorders, inflammation, respiratory diseases, cancers, etc. A cigarette smoker is exposed to a number of harmful substances. In this study we hypothesized that smoking causes inflammatory reactions and induces hyperthrombic state in the body which may be reflected in erythrocyte sedimentation rate (ESR), total leucocyte count (TLC), differential leucocyte count (DLC) and platelet count values. The purpose of the study was to study the effects of cigarette smoking on erythrocyte sedimentation rate, total leucocyte count and platelet count in adult male smokers and to compare the results with non-smokers and to establish a relationship between the duration and quantity of smoking with the change in ESR, TLC, DLC and platelet count. A cross sectional study was conducted in the department of Pathology on 86 healthy male subjects (smokers=43 and non-smokers=43). ESR was estimated using Westergrens method. TLC, DLC and platelet counts were estimated using HORIBA Pentra ES60 autoanalyzer. TLC and basophil counts were significantly higher in smokers than in non-smokers (p<0.05). The mean value of ESR was higher among smokers than non-smokers but it was statistically insignificant. Platelets counts showed no significant difference between smokers and non- smokers. No correlation was observed in various blood parameters and smoking (in pack years). We conclude that smoking initiates an inflammatory response as evidenced from raised TLC, monocyte and basophil counts.
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Joseph, Liya. "Leucocyte count in children with complicated and uncomplicated acute appendicitis: a comparative study." International Surgery Journal 6, no. 12 (2019): 4308. http://dx.doi.org/10.18203/2349-2902.isj20195178.
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Background: Identification of complicated and uncomplicated acute appendicitis is important in children. In acute appendicitis, along with clinical evaluation and staging, many laboratory tests have been used. The aim of the study was to compare total leucocyte count in children with uncomplicated and complicated acute appendicitis in different age groups.Methods: Retrospective cohort study was performed in children who underwent appendicectomy, in a Government tertiary care institution between January 2017 and December 2018. 206 patients were divided into complicated and uncomplicated appendicitis. Total leucocyte count at time of admission was compared according to age. Unpaired t test and Chi-square test were used for statistical analysis.Results: There were 136 males and 70 females. 107 patients (51.94%) had complicated and 99 (48.06%) had uncomplicated appendicitis. Mean leucocyte count per µl in uncomplicated appendicitis was 18993±3540 in <5 years, 17155±3386 in 5-10 years and 15833±3613 in 10-15 years. The mean leucocyte count for complicated appendicitis was 19974±3658 in <5 years, 17727±4487 in 5-10 years and 17220±3411 in 10-15 years age group. In 10-15 years group, patients with complicated acute appendicitis had statistically significant higher values of mean total leucocyte count.Conclusions: Total leucocyte count can be used as marker of severity of acute appendicitis in children older than 10 years. In children with clinical suspicion of acute appendicitis, total leucocyte count >20000 per µl signifies complicated appendicitis in all age groups.
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Hebbar, Shripad, Mehak Misha, and Lavanya Rai. "Significance of Maternal and Cord Blood Nucleated Red Blood Cell Count in Pregnancies Complicated by Preeclampsia." Journal of Pregnancy 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/496416.
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Objectives.To evaluate the effect of preeclampsia on the cord blood and maternal NRBC count and to correlate NRBC count and neonatal outcome in preeclampsia and control groups.Study Design.This is a prospective case control observational study.Patients and Methods.Maternal and cord blood NRBC counts were studied in 50 preeclamptic women and 50 healthy pregnant women. Using automated cell counter total leucocyte count was obtained and peripheral smear was prepared to obtain NRBC count. Corrected WBC count and NRBC count/100 leucocytes in maternal venous blood and in cord blood were compared between the 2 groups.Results.No significant differences were found in corrected WBC count in maternal and cord blood in cases and controls. Significant differences were found in mean cord blood NRBC count in preeclampsia and control groups (40.0±85.1and5.9±6.3,P=0.006). The mean maternal NRBC count in two groups was2.4±9.0and0.8±1.5, respectively (P=0.214). Cord blood NRBC count cut off value ≤13 could rule out adverse neonatal outcome with a sensitivity of 63% and specificity of 89%.Conclusion.Cord blood NRBC are significantly raised in preeclampsia. Neonates with elevated cord blood NRBC counts are more likely to have IUGR, low birth weight, neonatal ICU admission, respiratory distress syndrome, and assisted ventilation. Below the count of 13/100 leucocytes, adverse neonatal outcome is quite less likely.
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Ezeh, Gladys Chinelo, Samuel Okwudili Onoja, Maxwell Ikechukwu Ezeja, Samuel Chukwunyere Udem, and Aruh Otta Anaga. "Splenic and Leucocytic Responses in Wistar Rats Exposed to Chronic Doses of Hydromethanol Extract of Helianthus annuus Leaf in Feed." Advanced Research in Life Sciences 5, no. 1 (2021): 12–17. http://dx.doi.org/10.2478/arls-2021-0024.
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Abstract To evaluate the effects of the hydromethanol extract of Helianthus annuus on leucocyte profile and spleen histology after prolonged exposure to Wistar rats. This study involved the incorporation of varied concentrations (2.50, 5.00 and 10.00 mg/10 g) of hydromethanol extract of H. annuus in feed and feeding same to Wistar rats for 90 consecutive days. Blood samples were collected from the retro-orbital plexus of the rats on days 30, 60 and 90, for leucocyte count. Histopathological examination of the spleen was also conducted. The extract treatment did not cause a significant (p >0.05) change in the leucocyte profile and the spleen histology in the treated rats when compared to the normal control rats. On day 90, the total leucocyte counts of 15.24 ± 1.47, 12.69 ± 0.84 and 16.29 ± 3.36 for the groups that were treated with extract 2.50, 5.00 and 10.00 mg/10 g feed respectively, were not significantly (p > 0.05) different when compared with the total leucocyte count (12.01 ± 0.77) of the control group. The findings suggest that hydromethanol extract of H. annuus do not have a significant effect on the leucocyte profile and the histology of spleen.
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Sajjad, Zunera, Sunila Tashfeen, Samrah Shahid, et al. "Correlation of Total Leucocyte Count, Neutrophil to Lymphocyte Ratio and Platelet Count with Duration of Hospital Stay in Dengue Fever." Life and Science 6, no. 1 (2025): 06. https://doi.org/10.37185/lns.1.1.466.
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Objective: To assess the correlation of total leucocyte count (TLC), neutrophil to lymphocyte ratio (NLR), and platelet count with the duration of hospital stay in dengue patients.Study Design: A cross-sectional study.Place and Duration of Study: The study was conducted at the Department of Haematology and Dengue Ward, Pak Emirates Military Hospital (PEMH) Rawalpindi, Pakistan from January 2023 to February 2023.Methods: Comprised 136 confirmed dengue-positive patients who were admitted to PEMH with symptoms of fever. All the participants were requested for their informed consent before their enrolment in the study. A 3 ml venous sample was taken, and complete blood counts were determined by Sysmex XN-3000.TLC, Hematocrit, platelet count, and differentials were measured while Neutrophil the neutrophil-to-lymphocyte ratio was calculated. Patients were followed in hospital and their total hospital stay was noted. Correlation of total leucocyte count, neutrophil to lymphocyte ratio, and platelet count in dengue patients with duration of hospital stay was noted.Results: TLC and the neutrophil-to-lymphocyte ratio did not show any significant correlation with hospital stay in dengue patients. However, platelet count was found to be negatively correlated with hospital stay duration (r = -0.864, P = 0.00).Conclusion: Platelet count has a significant negative correlation with hospital stay in dengue patients and is found to be a good predicting factor for indoor stay of dengue patients. How to cite this: Sajjad Z, Tashfeen S, Shahid S, Bibi A, Irfan R, Naeem U, Butt MN. Correlation of Total Leucocyte Count, Neutrophil to Lymphocyte Ratio and Platelet Count with Duration of Hospital Stay in Dengue Fever. Life and Science. 2025; 6(1): 15-20. doi: http://doi.org/10.37185/LnS.1.1.466
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Nasiruddin, Syed, Jayanth D.H., Udaya Shankar, and Arjun C. "The Diagnostic Value of Total Leucocyte Count in Acute Appendicitis and Its Complications." New Indian Journal of Surgery 8, no. 2 (2017): 139–43. http://dx.doi.org/10.21088/nijs.0976.4747.8217.22.
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Sonal, Agarwal. "A Prospective Study on the Levels of Serum Uric acid & Serum lactate dehydrogenase in patients suffering from Leukaemia." International Journal of Pharmaceutical and Clinical Research 14, no. 10 (2022): 1040–46. https://doi.org/10.5281/zenodo.13309591.
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<strong>Background: </strong>An early diagnosis & timely treatment can play an important role in improving the prognosis & quality of life in leukaemic patients. Estimation of serum uric acid & serum lactate dehydrogenase in patients suffering from leukaemia have emerged as acceptable markers in monitoring the prognosis of such cases especially when treatment is ongoing. <strong>Aims:</strong> Estimation of Serum uric acid & lactate dehydrogenase levels in leukemic patients. <strong>Material & Method:</strong> The present study recruited 60 patients who were diagnosed as leukaemic (acute or chronic, lymphoid or myeloid) patients of either sex, admitted in Department of Medicine of our Hospital from Dec 2021 to May 2022. Patients with previous history of chemotherapeutic drugs & who didn’t give consent were excluded. For all the patients complete blood count, Hb%, serum lactate dehydrogenase and serum uric acid levels were estimated. Correlation between Serum uric acid &lactate dehydrogenase levels with total leucocyte count was assessed. <strong>Results:</strong> Maximum patients were within 21-30 years age range, mean±SD being 41.67±18.24 years with 57% males & 43% females. The commonest type of leukaemia was chronic myeloid (54%), followed by acute myeloblastic (22%), chronic lymphoblastic (13%) and acute lymphoblastic type (11%). High Hb% was observed in chronic lymphoblastic type & lowest in acute lymphoblastic leukaemia. Mean total leucocyte count observed was 48660 (mm3). Low total leucocyte count was observed in acute type of leukaemia while higher values in chronic leukaemias. Mean serum uric acid was found to be 7.83±1.82 mg/dl with 64% of patients having concentration>7.2 mg/dl. Statistically significant difference was observed in the mean serum uric acid concentrations within different types of leukaemia (p<0.05). Mean LDH level was 801.07±202.54 IU/L. In 89% of study subjects Serum LDH was above normal range i.e.>460 IU/L. Statistically significant difference was noted between all the different types of leukaemia, when comparing mean LDH levels except between AML& CML (p>0.05). A strong correlation between increased total leucocyte counts and mean serum uric acid &lactate dehydrogenase levels were observed (p<0.05). <strong>Conclusion: </strong>Serum uric acid & serum lactate dehydrogenase levels were found to important & significant prognostic markers within patients suffering from leukaemia. The serum levels significantly increased with total leucocyte counts & thus independently assess the deteriorating prognosis in such patients.
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Ndrepepa, Gjin, Siegmund Braun, Raisuke Iijima, et al. "Total leucocyte count, but not C-reactive protein, predicts 1-year mortality in patients with acute coronary syndromes treated with percutaneous coronary intervention." Clinical Science 116, no. 8 (2009): 651–58. http://dx.doi.org/10.1042/cs20080298.
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Although an association between elevated leucocyte count and mortality in patients with ACS (acute coronary syndromes) has been established, the independence of this association from coronary risk factors and C-reactive protein has been inadequately studied. In the present study, this prospective registry included 4329 patients with ACS treated with PCI (percutaneous coronary intervention): 1059 patients with STEMI [ST-segment elevation MI (myocardial infarction)], 1753 patients with NSTEMI (non-STEMI) and 1517 patients with unstable angina. Blood samples were obtained before angiography for leucocyte count and C-reactive protein measurements. The primary outcome of this analysis was 1-year mortality. At 1 year, 345 patients (8%) had died: 45 patients in the 1st tertile, 93 patients in the 2nd tertile and 207 patients in the 3rd tertile of leucocyte count [Kaplan–Meier estimates of mortality, 3.2%, 6.4% and 14.1% with an OR (odds ratio)=2.42, 95% CI (confidence interval)1.78–3.12; P<0.001 for tertile 3 compared with tertile 2 and an OR=1.99, 95% CI 1.77–2.25; P<0.001 for tertile 2 compared with tertile 1]. The Cox proportional hazards model adjusting for coronary risk factors, ACS presentation, extent of coronary artery disease, C-reactive protein and other covariates identified leucocyte count with a HR (hazard ratio)=1.05 (95% CI 1.02–1.07; P<0.001 for 1000 cells/mm3 increase in the leucocyte count), but not C-reactive protein (HR=1.13, 95% CI 0.95–1.34; P=0.15 for a 1 tertile increase in the C-reactive protein concentration) as an independent correlate of 1-year mortality. We conclude that elevated leucocyte count, but not C-reactive protein, predicts 1-year mortality independent of cardiovascular risk factors across the entire spectrum of patients with ACS treated with PCI.
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Baksaas, Svein T., Hanne I. Flom-Halvorsen, Eivind Øvrum, et al. "Leucocyte filtration during cardiopulmonary reperfusion in coronary artery bypass surgery." Perfusion 14, no. 2 (1999): 107–17. http://dx.doi.org/10.1177/026765919901400204.
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Postoperative organ dysfunction after cardiac operations has been related to the damaging effects of cardiopulmonary bypass (CPB). These complications are considered to be mediated partly by complement activation and subsequent activation of leucocytes due to the contact between blood and the large nonendothelial surfaces in the bypass circuit. Removal of leucocytes by filtration during the reperfusion period may potentially reduce the postoperative morbidity after CPB. Forty patients undergoing elective, primary coronary artery bypass grafting were randomized to initial identical bypass circuits until the aortic crossclamp was released. Then, the ordinary arterial line filter was closed and either a leucocyte depletion filter ( n = 20), or a control filter ( n = 20) was incorporated in the circuits during the reperfusion period of CPB. Blood samples were drawn at fixed intervals and analysed for white blood cell and platelet counts, plasma concentration of myeloperoxidase, C3-complement activation products, the terminal complement complex, and interleukins (IL)-6 and -8. The numbers of circulating white blood cells in the leucocyte-depleted group decreased during the reperfusion period from 5.5 (4.8-6.8) to 5.3 (4.4-6.2) × 109/l, and increased in the control group from 6.5 (5.1-8.0) to 7.4 (5.7-9.0) × 109/l. Two hours postoperatively the total white blood cell count in the leucocyte-depleted group was 14.7 (12.1-17.2) × 109/l, and in the control group 17.6 (14.5-20.7) × 109/l. The differences between the groups were statistical significant ( p= 0.05). There were no statistically significant differences between the groups with regard to other test parameters or clinical data. We conclude that the use of leucocyte filters during the reperfusion period in elective coronary artery bypass surgery significantly reduced the number of circulating leucocytes, whereas no effects were seen for granulocyte activation measured as myeloperoxidase release, platelet counts, complement activation, or IL-6 and -8 release. The clinical benefit of leucocyte filters in routine or high risk patients remains to be demonstrated and is suggested to be dependent on both the efficacy and the biocompatibility of the filters.
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Ojha, AR, and UR Aryal. "Leucocytosis in Febrile Seizure." Journal of Nepal Paediatric Society 31, no. 3 (2011): 188–91. http://dx.doi.org/10.3126/jnps.v31i3.4577.
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Introduction: Febrile seizure (FS) is a common condition affecting 2-5% of children. Peripheral blood leucocyte count with its differential is an initial test looking for the cause of fever and high count is usually accounted for the seizure activity. Objectives: To find the incidence of febrile seizure and to evaluate the relationship between fever duration before seizure, seizure duration and the total leucocyte as well as neutrophil response. Methodology: It is a cross sectional study done at Kathmandu Medical College and Teaching Hospital, Kathmandu, Nepal, for one year. After an informed consent, children from 6 months to 6 years with FS were admitted. Those with afebrile seizures and who refused to give consent were excluded. A detail history and examination was done on admission. All were investigated for the source of fever including total and differential count. Results: Out of a total 1742 children admitted, 115 (6.6%) children had febrile seizure. Simple febrile seizure was observed in 93(81%) and 22(19%) was complex febrile seizure. 42% of them had leucocytosis. The duration of fever before the onset of seizure is found to be negatively correlated with total leucocyte count (r = -0.418, p<0.001) and neutrophils count alone (r = -0.375, p<0.001). The duration of seizure is not correlated to both the total leucocyte count (r = -0.162, p = 0.85) and the neutrophil (r = -0.109, p= 0.247). Conclusion: The incidence of febrile seizure is 6.6%. Leucocytosis and neutrophilia in children is negatively correlated with the duration fever before the onset of seizure, associated with underlying infection if any and is not related to seizure event and its duration. Thus any child with febrile seizure with high leucocyte count should be evaluated for infection. Key words: Fever; Leucocytosis; Neutrophilia; Seizure DOI: http://dx.doi.org/10.3126/jnps.v31i3.4577 J Nep Paedtr Soc 2011;31(3):188-191
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Grieve, Paul A., and Barry J. Kitchen. "Proteolysis in milk: the significance of proteinases originating from milk leucocytes and a comparison of the action of leucocyte, bacterial and natural milk proteinases on casein." Journal of Dairy Research 52, no. 1 (1985): 101–12. http://dx.doi.org/10.1017/s0022029900023931.
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SUMMARYThe caseinolytic activities at pH 6·8 of polymorphonuclear (PMN) and mononuclear leucocyte homogenates (equivalent to a level of 106cells/ml milk) were less than the levels of natural milk proteinase activity found in milk from healthy cows. Bulk milks contained ∼ 4 times more milk proteinase activity than the composite milks from individual healthy cows. Isolated blood leucocytes, when added to raw milk of good bacteriological quality and stored at 5 °C, did not readily degenerate and had no detectable effect on the milk proteins even when these cells were completely disrupted by homogenization of the milk. Pasteurization of milk which contained leucocytes caused loss of cell vitality. Extracellular proteinases of psychrotrophic bacteria growing in milk were not detected until the early stationary phase of growth. The total viable count at which this occurred varied greatly. Proteinase production by a pure culture ofPseudomonas fluorescenswas not detected in milk stored at 5 °C until a viable count of ∼ 109colony forming units (c.f.u.)/ml was obtained, whilst normal bulk milks stored at 5 °C produced detectable levels of extracellular proteinase(s) when the psychrotrophic flora reached 107–108c.f.u./ml. Casein proteolysis by PMN and mononuclear leucocyte homogenates resulted in similar polypeptide maps, but plasmin and bacterial proteinase isolated from a strain ofSerratia marcescensresulted in polypeptide maps different from each other and from that produced by the leucocyte proteinase(s). The rate of proteolysis of caseins by the different proteinase sources appeared to be in the order αsl- > β- > > κ-casein for the leucocyte extracts, β- > αsl- > > > κ-casein for bovine plasmin and β- ≈ κ- > αsl-casein forS. marcescensproteinase.
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Gebhard, Catherine, Aurel Toma, Zhao Min, et al. "Preprocedural Leucocyte Count Predicts Risk in Patients with Coronary Chronic Total Occlusion." Thrombosis and Haemostasis 117, no. 11 (2017): 2105–15. http://dx.doi.org/10.1160/th17-06-0381.
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Background As technologies of percutaneous coronary intervention (PCI) for coronary chronic total occlusions (CTO) have improved, great uncertainty exists regarding patient selection and long-term benefit of CTO-PCI. Given that white blood cell (WBC) count has been associated with cardiovascular risk, we hypothesized that the latter might provide incremental prognostic value in patients undergoing CTO-PCI. Methods and Results Our study population consisted of 1,262 consecutive patients (76.3% males, mean age of 67.7 ± 10.3 years) who underwent elective PCI at our centre between January 2002 and December 2008. Four hundred seventy-five patients had at least one CTO, while 787 patients with non-occlusive coronary lesions served as controls. Baseline WBC count was higher in CTO patients as compared with controls (8,072 ± 3,459/μL vs. 7,469 ± 2,668/μL, p = 0.001) and independently predicted the occurrence of a CTO lesion (odds ratio: 1.8; 95% confidence interval [CI]: 1.3–2.4; p < 0.001). After a median follow-up of 3.1 years (interquartile range: 2.1–4.2 years), CTO patients with WBC counts ranging in the highest tertile had significantly worse outcomes than CTO patients with lower WBC counts (log-rank = 0.009 for all-cause mortality and log-rank = 0.01 for major adverse cardiac events). These associations were not seen in controls. Accordingly, elevated WBC count was identified as a significant predictor for all-cause mortality (adjusted hazard ratio: 3.1; 95% CI: 1.6–6.2; p = 0.001) in CTO patients but not in patients with non-occlusive coronary artery disease (p int = 0.088). Conclusion Assessment of the inflammatory status of CTO patients may be an important element in selecting CTO patients at low risk who may be referred to CTO-PCI.
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Dr., Akhlaq Ahmad Tabassom Dr. Muhammad Ahmed Chaudhry Dr. Asad Mehmood Dr. Zuhair Zubair. "ASSOCIATION OF HAEMATOLOGICAL PARAMETERS REFERENCE VALUES VARIATION WITH VARIOUS ATTRIBUTING FACTORS." Indo American Journal of Pharmaceutical Sciences 05, no. 06 (2018): 5782–88. https://doi.org/10.5281/zenodo.1299300.
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<strong><em>Objectives: </em></strong><em>We assessed reference </em><em>Hematological parameters values variation including Total Leucocyte Count (TLC), Hemoglobin (Hb), Platelet Counts (PLT) and Red Blood Cells (RBC) in neonates and its comparison with the similar natured research international studies.</em> <strong><em>Subjects and Methods: </em></strong><em>Research was </em><em>descriptive in nature conducted at Services Hospital, Lahore (Department of Hematology) in the time span of six months starting from August, 2016 to January, 2017. Non-probability method of sampling was used for selection of a sample that consisted of 400 neonates. We assessed the samples of the blood by using an automated hematology analyzer (Sysmex Kx-21) for Total Leucocyte Count (TLC), Hemoglobin (Hb), Platelet Counts (PLT) and Red Blood Cells (RBC).</em> <strong><em>Results: </em></strong><em>Reference values taken as (mean 7 SD) for RBC, TLC and platelets count were respectively </em><em>(4.931012 / l & 0.54), (16.109 / l & 5.35) and (258.499109 / l & 70.5). These mean values were more than the values reported in the international research studies. Reference mean Hb value was low than the internationally reported values as (14g/dl & 2.5) which was reported (16.89 g/dl & 1.92) in the international research studies. As per the comparative research the mean values and SD in the international research study were observed about RBC, TLC and Platelets as (4.21012 / l & 1.2), (12.109 / l & 7) and (200109 / l & 50).</em> <strong><em>Conclusions: </em></strong><em>Our </em><em>hematological parameters reference values of neonates are not same as implemented in international research studies; which leads to a conclusion that numerous and different ethnic, maternal, nutritional, environmental, cultural and socioeconomic factors have an effect on the neonatal hematological parameters.</em> <strong>Key words: </strong><em>Total Leucocyte Count (TLC), Hemoglobin (Hb), Platelet Counts (PLT) and Red Blood Cells (RBC), Neonates, Hematological and Parameters.</em>
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Madineni, Bhavana Chowdary, Sreeramulu Patrapalli Nadipanna, and Krishna Prasad Kamisetty. "Correlation of Early Total Leucocyte Count and Red Cell Distribution Width with Outcome in Trauma." Journal of Evolution of Medical and Dental Sciences 10, no. 17 (2021): 1241. http://dx.doi.org/10.14260/jemds/2021/264.
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BACKGROUND Trauma is the leading cause of morbidity and mortality in young adults. Risk stratification in these patients remains challenging even today. There is a need for a readily available simple prognostic method to categorise these patients and predict the morbidity. We intend to measure and correlate red cell distribution width and total leucocyte count in patients presenting with trauma, within 24 hours of injury, with the outcome. METHODS We included 52 haemodynamically stable, previously healthy, trauma patients who were admitted from November 2019 to April 2020, who did not require emergency surgery and analysed them prospectively. Complete blood picture obtained within 24 hours of injury was analysed in terms of correlation with outcome. The outcome was measured in terms of length of hospital stay. Correlations were performed with the Pearson correlation coefficient. RESULTS There was a statistically significant correlation between total leucocyte count (TLC) and length of hospital stay (P < 0.001). The positive correlation found between red cell distribution width (RDW) and length of hospital stay was not statistically significant. The analysis showed that high leucocyte count and red cell distribution width done within 24 hours of injury, increased patients’ stay in the hospital. CONCLUSIONS TLC and RDW can be used as readily available and simple markers, as an adjunct in early prediction of higher morbidity in patients presenting with trauma. KEY WORDS Injuries, Polytrauma, Blood Cell Count, Leucocytosis, Red Cell Indices
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Hämäläinen, M. T., P. Grönroos, and J. M. Grönroos. "Do Normal Leucocyte Count and C-Reactive Protein on Admission to Hospital Exclude a Life-Threatening Attack of Acute Pancreatitis?" Scandinavian Journal of Surgery 91, no. 4 (2002): 353–56. http://dx.doi.org/10.1177/145749690209100408.
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Background and Aims: The early severity assessment of an attack of acute pancreatitis is clinically of utmost importance. The aim of the present work was to study the role of leucocyte count and C-reactive protein (CRP) measurements on admission to hospital in assessing the severity of an attack of acute pancreatitis. In particular, patients with a life-threatening attack of acute pancreatitis but a normal leucocyte count and CRP level were sought. Material and Methods: A total of 1050 attacks of acute pancreatitis were treated at Turku University Central Hospital during the years 1995–1999. Leucocyte count and C-reactive protein (CRP) value were determined on admission to hospital. There were 58 life-threatening attacks of acute pancreatitis (group A). Fifty-eight consecutive mild attacks served as controls (group B). The number of patients with both values normal, only leucocyte count raised, only CRP level raised and both values raised were calculated in the groups A and B. Results: Both leucocyte count and CRP level were significantly ( P < 0.001 in both comparisons) higher on admission to hospital in patients with a life-threatening disease (group A) than in those with a mild disease (group B). Group A contained no patients with both values in the normal range. In group B, one fifth of the patients had both values normal. Conclusion: It is very unlikely that acute pancreatitis proves to be a life-threatening one when both the leucocyte count and CRP are normal on admission to hospital. In the present 1050 acute pancreatitis there were no patients with life-threatening disease but normal laboratory values on admission.
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Bhatkar, N. V. "Chromium (III) induced haematological alterations in Indian common carp, Labeo rohita (Ham.)." Journal of Applied and Natural Science 3, no. 2 (2011): 258–63. http://dx.doi.org/10.31018/jans.v3i2.192.
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The principle source of chromium in water bodies is discharged from industries which use large amount of chromates or dichromates. The freshwater fish, Labeo rohita was used as a model in the present studies to investigate the responses to chromium metal salt contamination in water bodies as it is the most common fish consumed widely in India. Haematological tests were carried out as these are the important diagnostic tools and are equally valuable as indicators of disease or stress due to pollutants and environmental fluctuations. The fishLabeo rohita were exposed to sublethal concentration of chromium chloride for 10, 20 and 30 days to study alterations in certain haematological parameters. The parameters under study were total erythrocyte count (TEC), haemoglobin (Hb gm%), total leucocyte count (TLC), differential leucocyte count (DLC) and pack cell volume (PCV). The studies revealed that chromium chloride-treated Labeo rohita exhibited decreased levels of total erythrocyte count (TEC), haemoglobinn (Hb gm%) and PCV whereas, total leucocyte count (TLC) was increased under thestress of chromium metal The decreased WBC count found after 30 days along with depleted Hb content and RBC count indicate dysfunctioning of haemopoietic systems along with dysleucopoiesis. Leucocytosis observed after 10 and 20 days exposure has been considered to be an adaptation to meet stressful conditions by animals. Increase in macrophages and basophils appears to be protective response during chromium exposure. An increasing trend in the mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were evident in fish exposed to sublethal doses of chromium chloride when compared with the control.
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Shafi, SheikhMuzamil, Misbha Afsheen, and FarooqA Reshi. "Total leucocyte count, C-reactive protein and neutrophil count: Diagnostic Aid in acute appendicitis." Saudi Journal of Gastroenterology 15, no. 2 (2009): 117. http://dx.doi.org/10.4103/1319-3767.48969.
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Jadhav, Dhanashri, Gaurav Singh, Madan Mishra, Abhinav Srivastava, and Shubhamoy Mondal. "Comparative evaluation of efficacy of C-reactive protein versus total leucocyte count as marker for monitoring patients with orofacial space infection of odontogenic origin." National Journal of Maxillofacial Surgery 14, no. 3 (2023): 406–12. http://dx.doi.org/10.4103/njms.njms_139_22.
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Objective: To compare and evaluate the efficacy of C-Reactive Protein and total leucocyte count as markers for monitoring patients of odontogenic space infection. Materials and Methods: Blood samples were taken preoperatively and post-operatively at day 1, day 2, day 3 and day 7 for measuring the levels of CRP and TLC. The trends of CRP and TLC were analysed against the Clinical Severity Scale (CSS). The study was carried out on patients of odontogenic space infection, and minimum of 50 patients were selected for this study. Comparative evaluation of C-reactive protein (CRP) versus total leucocyte count (TLC) was performed. Results: Data were analysed using Statistical Package for Social Sciences (SPSS) version 21. Inferential statistics were performed using Spearman Correlation. The level of statistical significance was set at 0.05. The result of the study demonstrates that the C-reactive protein (CRP) was found to be more consistent indicator for monitoring the patients of odontogenic space infection than TLC, Differential Leucocyte Count (DLC) and erythrocyte sedimentation rate (ESR). Conclusion: We conclude that CRP should be incorporated as monitoring tool, and it serves as a better indicator than TLC for managing patients with orofacial space infections of odontogenic origin.
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Gangwar, Kavisha, Brijesh Kumar Yadav, Neeraj Kumar Gangwar, and Vikas Sachan. "Cystic Endometrial Hyperplasia and Pyometra Complex in a Bitch." Indian Journal of Animal Reproduction 44, no. 2 (2023): 86–89. http://dx.doi.org/10.48165/ijar.2023.44.02.16.
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A 11 years old German Shepherd bitch with the history of abdominal distension, vomiting, and purulent vaginal dis charge was presented to Veterinary Clinical Complex, DUVASU, Mathura. Haematological examination revealed increase in total erythrocyte count and total leucocyte count while decrease in platelet count. The condition was treated with ovariohysterectomy and histopathological examination revealed the condition as cystic endometrial hyperplasia with pyometra complex.
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Patel, Umang, Mayur Shinde, Samir Patel, Jaishree Ganjiwale, and Bhalendu Vaishnav. "Multifactorial analysis of severity and outcome of COVID 19 infection in young, middle aged and old patients in a Government designated Covid Hospital." Journal of Health Sciences and Professions Education 1, no. 1 (2023): 23. https://doi.org/10.5455/jhspe.20230516041706.
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Context: Present study is one of very few single largest single-centre studies in India of more than 1000 patients which provides multifactorial analysis of 15 factors across three distinct age-groups viz., COVID 19 patients of three different age groups, viz., young ( 18-34 years), middle-age (35-64 years), old ( more than 64 years) and their correlation with severity of disease and outcome during second wave of Covid-19. Method and Material: Data of 1034 patients ( study-period:1st January to 31st May 2021) was retrieved and its multifactorial analysis carried out as regards clinical, biochemical and parameters, outcome and severity. Results: Number of young, middle aged and old patients were 93 (8.99%), 550 (53.19%) , and 391 (37.81%) respectively. There was significant association between: age and severity, age and outcome. There was significant association between Total WBC counts, Sodium, D Dimer, CRP, S.Ferritin, S.LDH, Total bilirubin, S.Urea and Albumin and severity except: S.Sodium and Total WBC count (not associated with severity in young age group). There was significant association between Total WBC counts, D Dimer, S.Ferritin, S.LDH, S.Sodium, S.Albumin and S.Urea and outcome except: S.Ferritin, S.LDH and Total WBC counts were not associated with outcome in young.S.LDH> 234, Sodium >145, S.Ferritin >292, S.Urea >40 and Total leucocyte counts >11,000 were statistically significant in association with outcome. Conclusion: Apart from age, elevated CRP, LDH and S. Sodium , S.Ferritin, Bl.Urea and Total leucocyte count are statistically significantly associated with severity and outcome.
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S., Soujanya1* D. Madhuri2 J. Jyothi3. "Cytological diagnosis and haematological alterations in transmissible venereal tumour." Science World a monthly e magazine 3, no. 9 (2023): 1240–45. https://doi.org/10.5281/zenodo.8370687.
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The study was conducted in 12 non-descriptive dogs (8 female and 4 male) with nodular tumour growths on external genitalia which were presented to Veterinary Clinical Complex, Rajendranagar, Hyderabad, Telangana for treatment. Impression smears were taken from the tumour mass and stained with Fields stain for cytological diagnosis. Cytologically, the tumours revealed homogenous highly cellular mass. The neoplastic cells were large, round with multiple punctate vacuoles in cytoplasm and the nuclear chromatin was coarse to reticulate which were suggestive of transmissible venereal tumour. After diagnosis the affected dogs were treated with Vincristin. Further blood samples were collected and analyzed for various haematological parameters. In dogs, after treatment with Vincristin the total erythrocyte count, hemoglobin, packed cell volume, total leucocyte count and platelet count were significantly (P<0.05) decreased in comparison with before treatment. In differential leucocytic count, the neutrophil percentage was significantly (P<0.05) decreased and lymphocytic percentage was significantly (P<0.05) increased in dogs after treatment in comparison with before treatment.
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Lubis, Nauval Gibran, Sugito Sugito, Zuhrawati Zuhrawati, et al. "EFEK PENINGKATAN SUHU TERHADAP JUMLAH LEUKOSIT IKAN NILA (Oreochromis niloticus) (The Effect of Temperature Increase on Leukocyte Count of Nile Tilapia (Oreochromis niloticus))." Jurnal Medika Veterinaria 10, no. 1 (2016): 31. http://dx.doi.org/10.21157/j.med.vet..v10i1.4033.
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The aim of this research was to find out the effect of water temperature increase on leucocyte count of nile tilapia. The blood sample from 9 tilapia with weigh of 40-50 g were used in this study. The research was conducted using completely randomized design (CRD) with 3 treatments and 3 replications. Treatment P1 as a control with aquarium temperature was maintained at 29±1 C. Water temperature in treatment P2 and P3 was maintained at 32±1 C and 35±1 C respectively. The aquarium size in each treatment group was 80x60x40 cm with height of water 30 cm. The treatment was done for 15 days and on day 16th, the blood were collected from caudal vein. Data were analyzed with analysis of variance (Anova) and followed with Duncan's multiple range test. The result showed that total leucocyte count (x 105/mm3) of nile tilapia in group P1, P2, and P3 were 3.08±0.88, 1.70±0.52, and 1.69±0.20 respectively. lts showed that an increase in temperature significantly affect (P<0.05) the leucocyte count of nile tilapia. The conclusion of this research is the increase in water temperature in aquarium decrease the leucocyte count of nile tilapia.
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Kurian, Amrita, Poornima H, and Abdul Salam. "Association of Total Leucocyte Count and Neutrophil to Lymphocyte Ratio with Short Term Major Adverse Cardiac Events after Acute ST Elevation Myocardial Infarction in a Tertiary Care Centre in South India." Galore International Journal of Health Sciences and Research 8, no. 2 (2023): 27–34. http://dx.doi.org/10.52403/gijhsr.20230206.
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Ischemic Heart Disease is a global health issue with developing countries bearing the brunt of the burden. The development of adverse cardiac events after an acute coronary event further aggravates the morbidity and mortality. In a developing country like India, employing inexpensive markers such as Total Leucocyte Count (TLC) and Neutrophil to Lymphocyte Ratio (NLR) can greatly aid prognostication in acute myocardial infarction. The study aimed at estimating the association of TLC and NLR with short term Major Adverse Cardiac Events (MACE) after acute STEMI. We also studied the association of Total Leucocyte Count and Neutrophil to Lymphocyte ratio with TIMI (Thrombolysis in Myocardial Infarction) score. This hospital based descriptive study that spanned over a year enrolled 270 patients admitted under General Medicine and Cardiology with STEMI. TLC and NLR were measured within 24 hours of admission. The subjects were followed up for MACE (namely heart failure hospitalization, compensated systolic dysfunction, arrhythmias, non-fatal reinfarction/stroke, and cardiovascular death) at the end of 1 week and 1 month. Among the 270 cases, 107 developed MACE after 1 week and 89 developed MACE after 1 month. The most common MACE was LV systolic dysfunction followed by arrhythmias. There was a significant association between NLR and MACE after 1 week (p value:0.04). Similarly, there was a positive association between NLR and TIMI score (p value:0.002). The association between total leucocyte count and MACE was not statistically significant. We concluded that NLR, a routine, easily available test was effective in predicting major adverse cardiac events after 1 week in acute STEMI. Keywords: Acute Coronary Syndrome; ST elevation myocardial infarction; Total leucocyte count; Neutrophil to Lymphocyte Ratio; Major Adverse Cardiac Events; Thrombolysis in Myocardial Infarction Score (TIMI score); LV systolic dysfunction
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Wickström, Erik, Karin Persson-Waller, Helena Lindmark-Månsson, Karin Östensson, and Åse Sternesjö. "Relationship between somatic cell count, polymorphonuclear leucocyte count and quality parameters in bovine bulk tank milk." Journal of Dairy Research 76, no. 2 (2009): 195–201. http://dx.doi.org/10.1017/s0022029909003926.
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The somatic cell count (SCC) in bovine bulk tank milk is presently used as an indicator of raw milk quality, reflecting the udder health status of the herd. During mastitis, SCC increases, mostly owing to an influx of polymorphonuclear leucocytes (PMN) from blood into milk, with a concomitant change in milk composition. Bulk tank milk samples were categorized according to their SCC, as well as polymorphonuclear leucocyte count (PMNC), to study relationships between SCC, PMNC and various raw milk quality traits, i.e. contents of total protein, whey protein, casein, fat and lactose, casein number, proteolysis and rheological properties. The proportion of PMN, obtained by direct microscopy, was significantly higher in samples with high SCC compared with low SCC samples. SCC and PMNC were strongly correlated, yielding a correlation coefficient of 0·85. High SCC samples had lower lactose and casein contents, lower casein number and more proteolysis than low SCC samples. Samples with high PMNC had a lower casein number than low PMNC samples. Samples with high and low SCC or PMNC did not differ in respect to rheological properties. Our results do not indicate that PMNC is a better biomarker than SCC for raw bulk tank milk quality, as previously proposed.
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P R, Athira, and Ramjeela S. "Assessment of Hemoglobin, Total Leucocyte Count and Platelet Count in Type II Diabetes Patients and Non-Diabetes Group - A Case Control Study." International Journal of Science and Research (IJSR) 12, no. 11 (2023): 916–17. http://dx.doi.org/10.21275/sr231112155238.
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Widjajanti, S., S. E. Estuningsih, Subandriyo ., D. Piedrafita, and H. W. Raadsma. "The effect of the liver fluke Fasciola gigantica infestation on the leucocyte eosinophil cell profile on sheep." Jurnal Ilmu Ternak dan Veteriner 9, no. 3 (2012): 191–96. https://doi.org/10.14334/jitv.v9i3.408.
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Eosinophil is one of the major leucocyte cell in the blood which specifically reacted on parasite infection, thus it is important to determine its profile against the F. gigantica infection. The aims of this study is to determine the differences of the eosinophil count profiles on the different breed of sheep infected with F. gigantica and its relation with the resistance of sheep bred against parasitic disease. Four groups of sheep consist of Indonesian Thin Tail (ITT) sheep, Merino sheep, backcross sheep (10 families) and F2 sheep were infected with 300 metacercariae of Fasciola gigantica. The total sheep used in this trial is 621. Those sheep were observed for 12 weeks and the blood samples were collected every 2 weeks after infection. The results showed that total eosinophil counts in all infected sheep increased after two weeks post infection and ITT sheep showed the highest counts. On the other hand, the mean fluke counts on ITT sheep is the lowest compared with the other groups of sheep. Merino and F2 sheep had the highest mean fluke counts. Three families of backcross sheep had the mean flukes count similar to ITT sheep and the other 7 families were similar to the Merino sheep. In conclusion, the highest total eosinophil count at the early stage of infection on ITT sheep might be related with the genetic resistance, which was showed by the lowest flukes count, and the resistance was inherited to some of the backcross sheep, which had similar flukes count with ITT sheep. Â Key words: Fasciola gigantica, eosinophil, sheep
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Sotiropoulos, Georgios C., Jörg Steinmann, Sabrina Stern, et al. "Donor Leucocytosis Predicts Bacterial and Fungal Contamination of the Preservation Solution in Visceral Organ Transplantation." Progress in Transplantation 28, no. 1 (2017): 24–28. http://dx.doi.org/10.1177/1526924817746681.
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Introduction: Contamination of the preservation solution may contribute to septic complications that can occur after transplantation and cause higher morbidity and mortality among recipients. The aim of this study was to determine potential donor-related predictors of positive microbiological findings in the preservation solution. Design: We retrospectively studied 16 donor parameters on data from our center for microbiological findings in the preservation solution used in solid-organ recovery. From January 2008 through December 2011, 976 solid organs were transplanted, and in 167, the solution was positive for contaminants. Results: The most frequently detected contaminant was coagulase-negative staphylococci. Only the donor leucocyte count (cutoff at 9.1 × 109/L) predicted positive microbiological findings in the preservation solution ( P = .0024). Multivariable regression analysis found that donor age, donor sex, intensive care unit stay, total number of organs recovered, and leucocyte count differentiated various categories of potentially pathogenic bacteria. Conclusion: Donor leucocyte count higher than 9.1 × 109/L predicts contamination of preservation solution.
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Meirina, Fathia, Bidasari Lubis, Tiangsa Sembiring, Nelly Rosdiana, and Olga Siregar. "Hematological scoring system as an early diagnostic tool for neonatal sepsis." Paediatrica Indonesiana 55, no. 6 (2016): 315. http://dx.doi.org/10.14238/pi55.6.2015.315-21.
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Background Sepsis was the leading cause of death in babies by30%-50% in developing countries. Early diagnosis of neonatalsepsis is still a difficult problem because of clinical features are notspecific. Blood culture is the gold standard, but it takes several daysand is expensive. The hematological scoring system (HSS) consistsof hematologic parameters (leucocyte count, polymorphonuclear(PMN) cells, degenerative changes, and platelet count) for earlydiagnosis of neonatal sepsis.Objective To measure HSS as an early diagnostic tool for neonatalsepsis.Methods A cross sectional study was conducted in March toJune 2013. Samples were collected by consecutive sampling.Fourty neonates suspected sepsis in neonatology unit H. AdamMalik Hospital, Medan, North Sumatera, underwent routineblood count, blood culture, and peripheral blood smear. Eachhematologic parameters were analysed using the HSS of Rodwellet al. The hematologic parameters were total leucocyte count, totalPMN cells, total PMN immature, I:T PMN ratio, I:M PMN ratio,degenerative changes, and platelet count. The total value revealedHSS score. Diagnostic study parameters were calculated.Results Ten of fourty neonates had sepsis based on blood culturewith positive predictive value (PPV) 73%, negative predictivevalue (NPV) 93%, ROC curve showed cut off point 0.902 (95%CI 0.803 to 1.0).Conclusion tool for neonatal sepsis.
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Pai Jakribettu, Ramakrishna, Rekha Boloor, Andrew Thaliath, et al. "Correlation of Clinicohaematological Parameters in Paediatric Dengue: A Retrospective Study." Journal of Tropical Medicine 2015 (2015): 1–7. http://dx.doi.org/10.1155/2015/647162.
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Dengue is one of the arthropod-borne (arbo) viral diseases transmitted by female mosquitoAedes aegypti. Dengue fever has a wide spectrum of clinical presentation ranging from flu-like illness to severe complicated stage of dengue hemorrhagic fever leading to mortality. This was a retrospective study conducted in a tertiary care hospital in Coastal Karnataka, South India, to know the correlation between the clinical presentation and haematological parameters in the paediatric cases presented with dengue symptoms. A total of 163 paediatric cases who presented fever and dengue-like illness were included in the study. Of which, 69 were confirmed dengue patients. Critical analysis showed that there was a significant difference in the haematological parameters like total leucocyte count, percent differential leucocyte count, and platelets count, in the erythrocyte sedimentation rate (P<0.05to 0.0001). Additionally, when compared to nondengue patients, even the liver function and renal function parameters were significantly deranged (P<0.05to 0.0001). Stratification based on NS1, IgG, and IgM showed significant alterations in the haematological, hepatic, and renal parameters. With respect to the treatment a small percentage of patients, that is, 8% (4 patients), required platelet transfusion as their counts went below 20,000/μL. Two patients succumbed to their illness while three required ICU stay.
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Gupta, Palak, Umesh Gurjar, B. S. Sharma, and M. L. Gupta. "Complication profile of scrub typhus and its association with total leucocyte count." International Journal of Contemporary Pediatrics 4, no. 1 (2016): 96. http://dx.doi.org/10.18203/2349-3291.ijcp20164585.
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Background: Recent reports from several parts of India indicate that there is a resurgence of scrub typhus. There have been a few studies analysing the association of various complications of scrub typhus with leukocyte count. The objective of this study was to study the association of various complications of scrub typhus with leukocyte count in children.Methods: A prospective study done at SPMCHI, SMS Medical College, Jaipur from August 2014 to November 2014. 75 Scrub typhus positive children were included in the study group. A detailed history of signs, symptoms, complications, demographic background was taken and relevant laboratory investigations done. The association between the complications of scrub and the total leukocyte count was studied, statistical analysis was done using Chi Square test.Results: Meningoencephalitis was most commonly seen complication in 14.7% followed by ARDS (9.3%), hepatitis (8%), AKI (6.7%), shock (6.7%) and myocarditis (1.3%). Meningoencephalitis and acute renal failure were more frequent among Scrub Typhus cases with leucopenia (p = 0.006, P = 0.011 respectively). It was observed that hepatitis was more frequent with leukocytosis, but was not statistically significant.Conclusions: Our study revealed that leukopenia has a significant association with meningoencephalitis and acute kidney injury.
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Pratiksha Sharma and Dr. Umesh Shukla. "Impact of Smokeless Tobacco Product Consumption on Certain Haematological Parameters in Albino Rats." Journal of Science Innovations and Nature of Earth 5, no. 1 (2025): 46–47. https://doi.org/10.59436/jsiane.335.2583-2093.
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The tobacco plant (Nicotiana tabacum) has historically been utilized as chewing tobacco globally. Snuff is a form of tobacco processed into small particles and packaged in cans or pouches. This study aimed to investigate the impact of snuff tobacco on certain hematological indicators in albino rats. Albino rats with a weight range of 100 to 150 grams were utilized in the study. The oral LD50 for tobacco snuff was established at 3 mg per 100 g of rat body mass. Group A served as the control and received no treatment, whereas group B was administered snuff in milligrams per body weight orally using a gavage tube daily for 28 days. Blood samples were collected under chloroform anesthesia and analyzed for total erythrocyte count, total leucocyte count, hemoglobin concentration, packed cell volume, erythrocyte sedimentation rate, and absolute values. Total Erythrocyte count (TEC) was significantly decreased in group B (5.41±0.04 million/mm3) as compared to the control (6.33±0.3 million/mm3). Total Leucocyte Count was significantly increased in group B (9.0±0.21 x109/L) respectively as compared to the control group A (7.2±0.28 x109/L). Haemoglobin concentration was significantly decreased. Smokeless tobacco may possibly affect all the Haematological parameters.
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Seemen Ghafoor, Azra Saleem, Abdullah Abbasi, and Shaheena. "Levels of Fructose-2,6-Bisphosphate in Lymphocytes of Diabetic Patients." JMMC 4, no. 1 (2013): 24–26. http://dx.doi.org/10.62118/jmmc.v4i1.337.
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Background: Patients with diabetes mellitus have infections more often than those without diabetes. Severalfactors predispose diabetic patients to infections, including an alteration in immune defense mechanism. Elevated levels of fructose-2,6- bisphosphate in lymphocyte have been shown in diabetic patients. The activation ofglycolysis by fructose -2,6- bisphosphate in peripheral blood mononuclear cells causes the accumulation of glycolytic metabolites and inhibits the activation of immune cells.Objective: To observe and compare the levels of fructose-2,6-bisphosphate in lymphocytes of diabetics and normal subjectsMaterial and Methods: 200 diabetic and 50 control subjects were selected for study .The subjects were evaluated for severity of diabetes and their fasting blood glucose, HbA1C, total leucocyte count, lymphocyte count andfructose-2,6-bisphosphate in lymphocytes were estimated.Results: The results show that mean fasting blood glucose, HbA1C, total leucocytes count and fructose-2,6-bisphosphate levels in lymphocytes were significantly higher (P<0.001) while lymphocyte count was significantlylower (P<0.001) in diabetic patients as compared to control group.Conclusions: It was concluded from the facts observed in this study that elevated levels of fructose-2,6-bisphosphate in lymphocytes and decreased number of lymphocytes may have induced chances of infections indiabetic patients.Keywords: Lymphocytes, Fructose-2,6-bisphosphate, Diabetes, Infections.
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Jain, Vibhuti, and Aklesh Kumar Jain. "White blood cell count on admission as prognostic marker for assessment of severity of acute myocardial infarction." International Journal of Clinical Trials 6, no. 3 (2019): 96. http://dx.doi.org/10.18203/2349-3259.ijct20192567.
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<p class="abstract"><strong>Background:</strong> High white blood cell/leucocyte counts were predicted as important biomarkers for future cardiovascular events in both healthy individuals and are having history myocardial infarction. The aim of the study was to assess the role of leucocytes as predictors of morbidity and mortality during the hospitalization of patients with acute myocardial infarction.</p><p class="abstract"><strong>Methods:</strong> This was a prospective study conducted on 79 patients with evolving STEMI attending the emergency department of Maharaja Yeshwant Rao Hospital, Indore during the period from November 2004 to July 2005. Blood total leucocyte count (TLC) was done in all the patients. All-cause mortality rate during the follow up period was defined as the primary end point of the study. Composite of death, reinfarction and heart failure till follow up day were defined as the secondary outcomes.</p><p class="abstract"><strong>Results:</strong> The mean age of the patients was 55.9±10.4 years. Male dominance was (86%) seen in the study. The mean TLC in the study population was 12345±4922/cumm. A total of 16 (20.2%) patients were died during 3 months of follow up. Statistically significant difference (p&lt;0.001) was seen for characteristics such as age, risk index score, mean blood pressure heart rate and the Kilip class between survivors and non-survivors. The mean difference of TLC and mean CKMB was greater in non-survivors compared to survivors but the difference was not significant (p=0.177). Age, risk index, Kilip class, serum creatinine and baseline TLC, was found to affect the occurrence of the events significantly with a p value of less than 0.05.</p><p class="abstract"><strong>Conclusions: </strong>The findings conclude that the high blood leucocyte count was proved to be an important prognostic factor for assessing the severity of acute myocardial infarction in study population.</p>
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Barua, Chiranjib, Md Nurul Anwar, Md Shahidullah, Sharmila Barua, and Nobel Chowdhury. "Role Of Serial C-reactive Protein (Crp) In Relation To Total Leucocyte Count, Platelet Count & Blood Culture For Early Diagnosis Of Neonatal Septicemia In Developing Countries." Journal of Chittagong Medical College Teachers' Association 24, no. 2 (2014): 22–25. http://dx.doi.org/10.3329/jcmcta.v24i2.60211.
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Neonatal septicemia is a clinical syndrome of systemic illness accompanied by bacteremia occuring in the first 28 days of life. Neonatal septicemia is one of the major causes of neonatal death in developing countries. Early diagnosis and treatment can prevent neonatal mortality and morbidity. The present study includes: 1) usefulness of CRP (C-reactive protein), Total Leucocyte Count, Platelet Count and Blood Culture in early diagnosis of Neonatal Sepsis, 2) significance of serial CRP in diagnosis of neonatal sepsis. 3) the prognostic value of CRP in neonatal sepsis. This is a prospective study done in neonatal ward, Chittagong Medical College Hospital and carried out from January 2008 to January 2011. Sample size was 300. One hundred fifty neonates with suspected sepsis as cases and 150 healthy babies as control were enrolled in this study. Seventy two percent of cases neonates were preterm and low birth weight. Common risk factors for neonatal septicemia which were identified in this study; preterm (72%), low birth weight (72%), premature rupture membrane (60%), chorioamnionitis (26%) and maternal urinary tract infection (16%). Out of 150 cases of suspected neonatal sepsis total 80.7%% had raised CRP, in initial sample 70.39% were CRP positive and in 2nd sample additional 9.31% case were CRP positive . In control group 91% were CRP negative. CRP was positive in 100% of culture proven sepsis. Sensitivity of CRP was 80.67% and specificity of CRP was 76.44%. Leucocytosis was observed in 7% of cases and leucopenia was found in 11% of cases. In 82 % cases leucocyte count was found normal. In control group, 95% had normal leucocyte count and 5% had leucocytosis but no leucopenia. Sensitivity of leucocyte count was 18% and specificity was 20.68%. Thrombocytopenia was found in 28% of case group. Out of 150 cases only 15.33% yielded growth of organisms in blood culture. Klebsiella was the most common pathogen isolated which was followed by E.coli and Strph. aureus. Sensitivity of blood culture was 15.33% and specificity was 100% Therefore serial CRP can be taken as alternative method for diagnosis of neonatal sepsis specially in developing countries where blood culture is not readily available.
 JCMCTA 2013 ; 24 (2): 22-25
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Barua, Chiranjib, Md Nurul Anwar, Md Shahidullah, Shahadat Hossain, Sharmila Barua, and Nobel Chowdhury. "Role of Serial C-reactive Protein (CRP) in Relation to Total Leucocyte Count, Platelet Count & Blood Culture for early Diagnosis of Neonatal Septicemia in Developing Countries." Journal of Bangladesh College of Physicians and Surgeons 32, no. 2 (2015): 61–65. http://dx.doi.org/10.3329/jbcps.v32i2.26032.
Full textAbstract:
Neonatal septicemia is a clinical syndrome of systemic illness accompanied by bacteremia occuring in the first 28 days of life. Neonatal septicemia is one of the major causes of neonatal death in developing countries. Early diagnosis and treatment can prevent neonatal mortality and morbidity. The present study includes: 1) usefulness of CRP (C-reactive protein), Total Leucocyte Count, Platelet Count and Blood Culture in early diagnosis of Neonatal Sepsis, 2) significance of serial CRP in diagnosis of neonatal sepsis. 3) the prognostic value of CRP in neonatal sepsis. This is a prospective study done in neonatal ward, Chittagong Medical College Hospital and carried out from January 2008 to January 2011. Sample size was 300. One hundred fifty neonates with suspected sepsis as cases and 150 healthy babies as control were enrolled in this study. Seventy two percent of cases neonates were preterm and low birth weight. Common risk factors for neonatal septicemia which were identified in this study; preterm (72%), low birth weight (72%), premature rupture membrane (60%), chorioamnionitis (26%) and maternal urinary tract infection (16%) . Out of 150 cases of suspected neonatal sepsis total 80.7%% had raised CRP, in initial sample 70.39% were CRP positive and in 2nd sample additional 9.31% case were CRP positive . In control group 91% were CRP negative. CRP was positive in 100% of culture proven sepsis. Sensitivity of CRP was 80.67% and specificity of CRP was 76.44%. Leucocytosis was observed in 7% of cases and leucopenia was found in 11% of cases. In 82 % cases leucocyte count was found normal. In control group, 95% had normal leucocyte count and 5% had leucocytosis but no leucopenia. Sensitivity of leucocyte count was 18% and specificity was 20.68%. Thrombocytopenia was found in 28% of case group. Out of 150 cases only 15.33% yielded growth of organisms in blood culture. Klebsiella was the most common pathogen isolated which was followed by E.coli and Strph. aureus. Sensitivity of blood culture was 15.33% and specificity was 100% Therefore serial CRP can be taken as alternative method for diagnosis of neonatal sepsis specially in developing countries where blood culture is not readily available.J Bangladesh Coll Phys Surg 2014; 32: 61-65
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Dhal, Nirjharini, Sridhar Panda, Namita Mohapatra, Naresh C. Pattanayak, and Rohan Pattanaik. "Study of haematological abnormalities in HIV infected patients and its correlation with CD4 counts." International Journal of Research in Medical Sciences 6, no. 9 (2018): 2937. http://dx.doi.org/10.18203/2320-6012.ijrms20183385.
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Background: To study and correlate the haematological abnormalities with CD4 cell counts in HIV infected patients diagnosed on OPD basis in S.C.B Medical College, Cuttack, before they are initiated on Antiretroviral (ARV) therapy.Methods: A 100, ELISA positive, untreated HIV patients were included in the study while those patients with history of any haematological disease, Chronic Kidney Disease (CKD), Chronic Liver Disease (CLD), underlying malignancy or on chemotherapy were excluded. Following clinical evaluation, haemoglobin levels (Hb. %), Total Leucocyte Count (TLC), Differential Leucocyte Count (DLC), Erythrocyte Sedimentation Rate (ESR), Platelet Count (PC), CD4 counts (by flow cytometry) and peripheral smear examination was done. They were staged as per WHO clinical staging guidelines given by NACO and statistical analysis was drawn by Fischer Exact Test and association between CD4 counts and haematological abnormalities were inferred.Results: The mean age of the patients was found to be 36.85±6.2 years with males (63%), married (80%) and rural population (78%) showing commonest mode of transmission of the virus as heterosexual route (94%). Most common clinical finding was found to be pallor (68%) with majority in stage III of AIDS. Mean TLC count was found to be 5872±2210 cells/mm 2.40% had leucopenia on TLC and 29% had neutropenia, 30% lymphocytopenia and 20% monocytopenia on DLC. Mean CD4 count was 89 cells per microliter and 79% were anaemic. CD4 counts did not statistically correlate either with WHO staging or cytopenias or haemoglobin levels. However, there was positive association between CD4 counts with anaemia, WHO stages of AIDS, lymphocytopenia and monocytopenia in this study.Conclusions: In this study we could ascertain that, majority were in WHO stage III of AIDS with CD4 counts <200 cells per microliter and blood findings of various cytopenias and anaemia. From our findings, we could correlate between WHO stage of AIDS, CD4 counts and haematological abnormalities thus, establishing the essence of our study.
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R A, Sureshbalaji, Prem Kumar S, Lavanya R, et al. "CORRELATION OF TOTAL LEUCOCYTE COUNT, EOSINOPHIL, NEUTROPHIL AND LYMPHOCYTE COUNTS WITH PULMONARY FUNCTION IN COPD PATIENTS." Journal of Evolution of Medical and Dental Sciences 6, no. 84 (2017): 5870–73. http://dx.doi.org/10.14260/jemds/2017/1275.
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Ghimire, P., P. Thapa, N. Yogi, and P. Ghimire. "Role of serum bilirubin as a marker of acute gangrenous appendicitis." Nepal Journal of Medical Sciences 1, no. 2 (2012): 89–92. http://dx.doi.org/10.3126/njms.v1i2.6606.
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Background: This study has compared the difference in serum bilirubin between patients with gangrenous and non-gangrenous appendicitis. Methods: A prospective analytical study of, 141 patients who underwent appendectomy, from March 2010 to March 2011 in Manipal Teaching Hospital, Pokhara, Nepal was carried out. Clinico-demographic data, Alvarado’s score, total serum bilirubin, total leucocyte count and histopathological report of all the cases were collected in a prestructured proforma. Comparison between gangrenous and non-gangrenous appendicitis groups was carried out using independent sample t test, Chisquare test, and direct logistic regression. The data was analyzed using SPSS 11.6 software. Result: Around 43% (61 out of 141) patients had gangrenous appendicitis and statistically significant difference was found between the two groups in total Alvarado’s score, total count and total bilirubin level. The effect size as indicated by eta square statistics was large for total bilirubin (eta squared=0.39) as compared to total Alvarado’s score (0.09) and total leucocyte count (0.05). Direct logistic regression model showed serum total bilirubin as the only independent variable to make a unique statistically significant contribution in predicting gangrenous appendicitis. Conclusion: Pre-operative assessment of serum total bilirubin can serve as an important maker of acute gangrenous appendicitis. DOI: http://dx.doi.org/10.3126/njms.v1i2.6606 Nepal Journal of Medical Sciences. 2012;1(2): 89-92
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MOHAMMAD ARSHAD and ANIL KUMAR. "EFFECT OF GENERATOR CAUSED AIR POLLUTION ON TOTAL LEUCOCYTE COUNT (TLC) IN RATTUS RATTUS." Knowledgeable Research: A Multidisciplinary Journal 2, no. 07 (2024): 1–4. http://dx.doi.org/10.57067/kr.v2i1.211.
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The study was conducted to observe the influence of Generator emissions on the Total Leucocytes Count (TLC) of the common house rat, Rattus rattus linnaeus, 1758 collected from Bareilly, Uttar Pradesh (India). The Total Leucocytes Count values were estimated in GroupI control and GroupII experimental which were exposed to generator emissions from 5KV diesel generator. The latter were further subdivided into four groups, based on distance of exposure [group A (2 feet), Group B (4feet), Group C (6feet), Group D (8 feet)] The results indicated significantly lower values in exposed rats suggesting that the emissions adversely affected TLC exposed as heart disease, high fever and cancer. When from 2 feet distance mortality of 33.33% was observed.
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MOHAMMAD ARSHAD and ANIL KUMAR. "EFFECT OF GENERATOR CAUSED AIR POLLUTION ON TOTAL LEUCOCYTE COUNT (TLC) IN RATTUS RATTUS." Knowledgeable Research A Multidisciplinary Journal 2, no. 07 (2024): 1–4. https://doi.org/10.57067/kr.v2i07.211.
Full textAbstract:
The study was conducted to observe the influence of Generator emissions on the Total Leucocytes Count (TLC) of the common house rat, Rattus rattus linnaeus, 1758 collected from Bareilly, Uttar Pradesh (India). The Total Leucocytes Count values were estimated in GroupI control and GroupII experimental which were exposed to generator emissions from 5KV diesel generator. The latter were further subdivided into four groups, based on distance of exposure [group A (2 feet), Group B (4feet), Group C (6feet), Group D (8 feet)] The results indicated significantly lower values in exposed rats suggesting that the emissions adversely affected TLC exposed as heart disease, high fever and cancer. When from 2 feet distance mortality of 33.33% was observed.
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Shivam, Kumar Sharma, Anilkumar Bhat Vedika, and Nayak N. Prasad. "Correlation of Liver Function Test and Total Leukocyte Count with Severity of Disease in Children with Dengue Fever: A Prospective Study." International Journal of Pharmaceutical and Clinical Research 16, no. 8 (2024): 438–44. https://doi.org/10.5281/zenodo.13384989.
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<strong>Introduction: </strong>Dengue fever is a vector borne disease manifesting in many clinical ways. It is a well-studied disease, and many research aims to understand various aspects of its severity and prognosis. Hepatic dysfunction, especially when accompanied by encephalopathy, significantly increases the risk of mortality. In addition, liver dysfunction can exacerbate bleeding manifestations and disseminated intravascular coagulation, both of which are associated with poor outcomes. Early detection and prompt supportive care are crucial to reducing mortality and morbidity. This study aims to explore the correlation between the severity of dengue fever in children and their total leukocyte count and liver function test. <strong>Method: </strong>The prospective observational study was conducted in the Department of Pediatrics at Rohilkhand Medical College and Hospital from November 2022 to October 2023. 55 participants were enrolled after obtaining informed consent from the guardians or parents, with clearance from the institutional ethics committee. Readings of LFTs and total leucocyte count was obtained. All children were further followed up for minimum 3 months or normalized LFT and Total leukocyte count whichever is earlier. <strong>Result: </strong>Laboratory tests revealed significant changes in the average Total Leukocyte Count (TLC) during the follow-up period, particularly among patients with Dengue Shock Syndrome (DSS). There were also notable differences in liver enzyme levels (SGOT and SGPT) between the initial and follow-up tests, reflecting the considerable impact of dengue on liver function. Additionally, average platelet counts varied with disease severity, highlighting a clear link between thrombocytopenia and the seriousness of dengue. However, no statistically significant changes were observed in leucocyte count or other laboratory parameters, such as PCV, Alkaline Phosphatase, Total Protein, and Albumin levels, across different forms of dengue. <strong>Conclusion: </strong>This study underscores the complex diagnostic and laboratory features of dengue virus infection in children, emphasizing the need for careful patient monitoring and tailored care strategies to improve outcomes based on the severity of the disease.
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Dhabangi, Aggrey, Ezra Musisi, and Dorothy Kyeyune. "Improving blood transfusion safety in resource-poor countries: a case study of using leucocyte reduced blood in Uganda." African Health Sciences 20, no. 2 (2020): 977–83. http://dx.doi.org/10.4314/ahs.v20i2.54.
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Background: The majority of blood transfusion safety strategies recommended by the WHO for resource-poor countries focus mainly on reducing the risk of transfusion-transmitted infections (TTIs). Other technologies such as leucocyte reduc- tion may represent complementary strategies for improving transfusion safety.
 Objective: To evaluate the role of using leucocyte reduced blood in a resource-poor country.
 Methods: Pre-storage leucocyte reduced (LR) red blood cells (RBCs) were specially prepared for the Tissue Oxygenation by Transfusion in severe Anaemia and Lactic acidosis (TOTAL) study, at the Uganda Blood Transfusion Services from Feb- ruary 2013 through May 2015. Quality control tests were performed to evaluate the procedure, and the incremental cost of an LR–RBC unit was estimated.
 Results: A total of 608 RBCs units were leucocyte reduced. Quality control tests were performed on 55 random RBCs units. The median (IQR) residual leucocyte count was 4 (0•5-10) WBC/uL, equivalent to 1•8x106 WBC per unit. The estimated incremental unit cost of leucocyte reduction was $37 USD per LR RBC unit.
 Conclusion: Leucocyte reduction of blood in a resource-poor country is doable although relatively costly. As such, its value in resource-poor countries should be weighed against other transfusion safety propositions.
 Keywords: Blood transfusion safety; leucocyte reduction; resource-poor countries.