Relevant bibliographies by topics / Total plasma protein

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Total plasma protein'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Total plasma protein"

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Schwarz, HP, W. Muntean, H. Watzke, B. Richter, and JH Griffin. "Low total protein S antigen but high protein S activity due to decreased C4b-binding protein in neonates." Blood 71, no. 3 (1988): 562–65. http://dx.doi.org/10.1182/blood.v71.3.562.562.

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Abstract Protein S, a vitamin K-dependent cofactor for activated protein C, exists in normal adult plasma in a free anticoagulantly active form and in an inactive form complexed to C4b-binding protein. Immunologic and functional levels of protein S and C4b-binding protein in plasma were determined for 20 newborn infants and compared with adult normal pooled plasma. Total protein S antigen levels averaged 23%, similar to other vitamin K-dependent plasma proteins. However, the protein S anticoagulant activity was 74% of that of adult normal plasma. This apparent discrepancy of activity to antige
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Schwarz, HP, W. Muntean, H. Watzke, B. Richter, and JH Griffin. "Low total protein S antigen but high protein S activity due to decreased C4b-binding protein in neonates." Blood 71, no. 3 (1988): 562–65. http://dx.doi.org/10.1182/blood.v71.3.562.bloodjournal713562.

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Protein S, a vitamin K-dependent cofactor for activated protein C, exists in normal adult plasma in a free anticoagulantly active form and in an inactive form complexed to C4b-binding protein. Immunologic and functional levels of protein S and C4b-binding protein in plasma were determined for 20 newborn infants and compared with adult normal pooled plasma. Total protein S antigen levels averaged 23%, similar to other vitamin K-dependent plasma proteins. However, the protein S anticoagulant activity was 74% of that of adult normal plasma. This apparent discrepancy of activity to antigen was sho
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HERNVANN, A., J. GONZALES, M. C. DIEMERT, and J. GALLI. "Determination of Total Protein in Human Seminal Plasma." Andrologia 19, S1 (2009): 233–37. http://dx.doi.org/10.1111/j.1439-0272.1987.tb02338.x.

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Rippe, B., M. Townsley, J. C. Parker, and A. E. Taylor. "Osmotic reflection coefficient for total plasma protein in lung microvessels." Journal of Applied Physiology 58, no. 2 (1985): 436–42. http://dx.doi.org/10.1152/jappl.1985.58.2.436.

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The osmotic reflection coefficient (sigma) for total plasma proteins was estimated in 11 isolated blood-perfused canine lungs. Sigma's were determined by first measuring the capillary filtration coefficient (Kf,C in ml X min-1 X 100g-1 X cmH2O-1) using increased hydrostatic pressures and time 0 extrapolation of the slope of the weight gain curve. Kf,C averaged 0.19 +/- 0.05 (mean +/- SD) for 14 separate determinations in the 11 lungs. Following a Kf,C determination, the isogravimetric capillary pressure (Pc,i) was determined and averaged 9.9 +/- 0.5 cmH2O for all controls reported in this stud
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Weber, J. A., and A. P. van Zanten. "Interference of plasma expanders in determination of total protein." Clinical Chemistry 35, no. 10 (1989): 2143–44. http://dx.doi.org/10.1093/clinchem/35.10.2143.

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GREGG, MICHAEL A., MIKE R. DUNBAR, JOHN A. CRAWFORD, and MICHAEL D. POPE. "Total Plasma Protein and Renesting by Greater Sage-Grouse." Journal of Wildlife Management 70, no. 2 (2006): 472–78. http://dx.doi.org/10.2193/0022-541x(2006)70[472:tpparb]2.0.co;2.

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Oztas, Yesim, Selma Unal, and Nuriman Ozgunes. "Plasma Protein Oxidation and Triglyceride Levels in Sickle Cell Anemia." Blood 114, no. 22 (2009): 2578. http://dx.doi.org/10.1182/blood.v114.22.2578.2578.

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Abstract Abstract 2578 Poster Board II-555 Introduction: A mutant and unstable hemoglobin is characteristic in sickle cell anemia (SCA) with an increased formation of methemoglobin, hemichrome and haemin. Increased oxidative stress and altered lipid balance in the plasmas of SCA patients have been documented previously. Lower total plasma cholesterol (TC) and higher-than-avarage triglyceride (TG) levels have also been reported in SCA patients compared to healthy controls. Plasma phospholipids (PL) were normal or increased according to various studies. However, to our knowledge only a few repor
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Zhu, Liguo, Liping Sun, Fengyan Fan, Dongqing Zhang, Changqing Li, and Deqing Wang. "Stability of plasma proteins and factors in Chinese universal pooled plasma." Journal of International Medical Research 47, no. 6 (2018): 2637–46. http://dx.doi.org/10.1177/0300060518798999.

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Objective This study aimed to determine the precision dose of Chinese universal pooled plasma (CUPP) developed by our laboratory, and the stability of plasma proteins and factors. Methods A total of 100 single fresh-frozen plasma (FFP) units were selected to test plasma proteins, including total protein, albumin, fibrinogen, factor V, factor VIII, antithrombin-III, and protein C. Different pooling protocols with 20, 40, 60, 80, and 100 units were used to optimize the number of pooled units. The pooled plasma was then used to further evaluate the optimal storage conditions and duration at 22°C,
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Parker, R. E., N. E. Wickersham, R. J. Roselli, T. R. Harris, and K. L. Brigham. "Effects of hypoproteinemia on lung microvascular protein sieving and lung lymph flow." Journal of Applied Physiology 60, no. 4 (1986): 1293–99. http://dx.doi.org/10.1152/jappl.1986.60.4.1293.

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Experiments were conducted on five chronically instrumented unanesthetized sheep to determine the effects of sustained hypoproteinemia on lung fluid balance. Plasma total protein concentration was decreased from a control value of 6.17 +/- 0.019 to 3.97 +/- 0.17 g/dl (mean +/- SE) by acute plasmapheresis and maintained at this level by chronic thoracic lymph duct drainage. We measured pulmonary arterial pressure, left atrial pressure, aortic pressure, central venous pressure, cardiac output, oncotic pressures of both plasma and lung lymph, lung lymph flow rate, and lung lymph-to-plasma ratio o
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Hipgrave Ederveen, Agnes L., Noortje de Haan, Melissa Baerenfaenger, Dirk J. Lefeber, and Manfred Wuhrer. "Dissecting Total Plasma and Protein-Specific Glycosylation Profiles in Congenital Disorders of Glycosylation." International Journal of Molecular Sciences 21, no. 20 (2020): 7635. http://dx.doi.org/10.3390/ijms21207635.

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Protein N-glycosylation is a multifactorial process involved in many biological processes. A broad range of congenital disorders of glycosylation (CDGs) have been described that feature defects in protein N-glycan biosynthesis. Here, we present insights into the disrupted N-glycosylation of various CDG patients exhibiting defects in the transport of nucleotide sugars, Golgi glycosylation or Golgi trafficking. We studied enzymatically released N-glycans of total plasma proteins and affinity purified immunoglobulin G (IgG) from patients and healthy controls using mass spectrometry (MS). The appl
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Dissertations / Theses on the topic "Total plasma protein"

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Melo, Aryse Martins. "Curva de parâmetros sanguíneos e de peso em (Spheniscus magellanicus) (Foster, 1781) pinguins de Magalhães com aspergilose durante reabilitação." Universidade Federal de Pelotas, 2015. http://repositorio.ufpel.edu.br:8080/handle/prefix/3373.

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Submitted by Ubirajara Cruz (ubirajara.cruz@gmail.com) on 2017-05-05T16:57:11Z No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Aryse_Martins.pdf: 857909 bytes, checksum: 6af8a55ce9256458f340496528f323af (MD5)<br>Approved for entry into archive by Aline Batista (alinehb.ufpel@gmail.com) on 2017-05-05T17:12:02Z (GMT) No. of bitstreams: 2 license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Dissertacao_Aryse_Martins.pdf: 857909 bytes, checksum: 6af8a55ce9256458f340496528f323af (MD5)<br>Made available in DSpace on 2017-05-05
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Silva, Katiane Queiroz da. "Efeito da adiÃÃo de plasma seminal e de sua composiÃÃo bioquimica sobre os espermatozÃides epididimÃrios de caprinos." Universidade Federal do CearÃ, 2009. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=4413.

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Conselho Nacional de Desenvolvimento CientÃfico e TecnolÃgico<br>O objetivo deste estudo foi verificar o efeito da adiÃÃo e da composiÃÃo do plasma seminal (PS) sobre as caracterÃsticas dos espermatozÃides epididimÃrios (EEP) de caprinos. Utilizaram-se oito machos caprinos para obtenÃÃo do PS, que foi obtido em coletas prÃvias e armazenado a -18o C atà que se procedessem a sua adiÃÃo aos EEP e as anÃlises bioquÃmicas. Os EEP foram obtidos da cauda do epidÃdimo pelo mÃtodo de castraÃÃo cirÃrgica. Do âpoolâ de EEP foram retiradas quatro alÃquotas de 100 &#956;L, sendo que em duas delas foram adi
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Silva, Katiane Queiroz da. "Efeito da adição de plasma seminal e de sua composição bioquimica sobre os espermatozóides epididimários de caprinos." reponame:Repositório Institucional da UFC, 2009. http://www.repositorio.ufc.br/handle/riufc/18815.

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SILVA, Katiane Queiroz da. Efeito da adição de plasma seminal e de sua composição bioquimica sobre os espermatozóides epididimários de caprinos. 2009. 43 f. : Dissertação (mestrado) - Universidade Federal do Ceará, Centro de Ciências Agrárias, Departamento de Zootecnia, Fortaleza-CE, 2009<br>Submitted by Nádja Goes (nmoraissoares@gmail.com) on 2016-08-02T14:51:18Z No. of bitstreams: 1 2009_dis_kqsilva.pdf: 313426 bytes, checksum: 9fae2725277c1fe6e2b27d9bb34c0908 (MD5)<br>Approved for entry into archive by Nádja Goes (nmoraissoares@gmail.com) on 2016-08-02T14:51:56Z (GMT) No. of bitstreams: 1 2
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Elejalde, Denise Adelaide Gomes. "Interface planta-animal em função da intensidade de aplicação de insumos em pastagem natural." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2011. http://hdl.handle.net/10183/36021.

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O trabalho foi conduzido na região da Campanha do RS, no município de Quaraí, com objetivo de avaliar a composição florística e bromatológica de pastagem natural submetida ou não à utilização de insumos, e os reflexos sobre o comportamento ingestivo e desempenho animal. Os tratamentos foram pastagem natural (PN), pastagem natural adubada (PNA) e melhorada com adubação + sobressemeadura de espécies hibernais (PNM). O delineamento experimental foi blocos ao acaso, com três repetições, sendo os dados submetidos à análise de variância considerando as estações do ano como medidas repetidas no tempo
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DŘÍZHALOVÁ, Blanka. "Bílkoviny krevní plazmy ovcí." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-252111.

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Plasma protein shave many important functions in the organism. Gamma globulins are carriers of immunoglobulins which play animportant role in the immune response. Their contentis primarily given by the health burden of the organism. The aimofthe study was to determine the individual protein fractions in the blood plasma of ewes and lambs, comparemutual relations between total plasma proteins and thein variol factions and assess the concentrations of individual plasma proteins, mainly globulin, in connection with the aktivity of the thyroidgland, physiological state, and increments. The samplin
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Oliveira, Luiza da Costa Corrêa. "Evaluation of a filter system to harvest plasma for total protein measurement in newborn calves of the holstein breed." Master's thesis, 2018. http://hdl.handle.net/10198/17816.

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The objective of this study was to evaluate a filter system to harvest plasma in order to assess failure of passive transfer (FPT) in newborn calves. Blood samples (n = 227) were collected from Holstein calves aged 1 to 6 days, from 4 commercial dairy herds in the northeast of Germany. Serum IgG concentration was determined in serum using an ELISA test. Failure of passive transfer was defined as IgG concentrations ≤ 10 mg/mL and used as a gold standard. An optical refractometer and 2 different digital BRIX refractometers were used to assess FPT in serum or plasma. Serum was obtained through ce
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Kullmann, Anne. "Effects of xylazine, romifidine and detomidine on haematology, serum biochemistry and splenic size in horses." Diss., 2011. http://hdl.handle.net/2263/29981.

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Alpha 2 agonists are frequently used in equine medicine. This study focused primarily on α2 agonist-induced changes in PCV and TSP. A secondary aim of this study was to investigate the effects of α2 agonist on selected serum biochemical parameters and splenic size in order to identify potential causes for the changes seen in PCV and TSP. Four healthy adult mares were treated in a blinded, randomized, cross-over design with a single dose of xylazine (0.5 mg/kg), romifidine (0.04 mg/kg) or detomidine (0.01 mg/kg) intravenously, or detomidine (0.02 mg/kg) intramuscularly. A 1-week washout period
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Books on the topic "Total plasma protein"

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Murer, Heini, Jürg Biber, and Carsten A. Wagner. Phosphate homeostasis. Edited by Robert Unwin. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0025.

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Inorganic phosphate ions (H2PO4−/ HPO42−) (abbreviated as Pi) are involved in formation of bone and generation of high-energy bonds (e.g. ATP), metabolic pathways, and regulation of cellular functions. In addition, Pi is a component of biological membranes and nucleic acids. Only about 1% of total body Pi content is present in extracellular fluids, at a plasma concentration in adults within the range 0.8–1.4 mMol/L (at pH 7.4 mostly as HPO42−), with diurnal variations of approximately 0.2 mM. A small amount of plasma Pi is bound to proteins or forms complexes with calcium. Under normal, balanc
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Book chapters on the topic "Total plasma protein"

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Sohn, Hae Won, Pavel Tolar, Joseph Brzostowski, and Susan K. Pierce. "A Method for Analyzing Protein–Protein Interactions in the Plasma Membrane of Live B Cells by Fluorescence Resonance Energy Transfer Imaging as Acquired by Total Internal Reflection Fluorescence Microscopy." In Methods in Molecular Biology. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-60761-404-3_10.

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Chan, Huai En Huang, Iman Jilani, Richard Chang, and Maher Albitar. "Cell-Free Bead-Based Detection of Total and Phosphorylated Proteins in Plasma and Cell Lysates." In Methods in Molecular Biology. Humana Press, 2007. http://dx.doi.org/10.1007/978-1-59745-323-3_10.

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Gupta, Prem, and Neelu Gupta. "Quantitative Estimation of Total Protein, Albumin, Globulins and Fibrinogen in Serum/Plasma." In Essentials of Practical Biochemistry. Jaypee Brothers Medical Publishers (P) Ltd., 2017. http://dx.doi.org/10.5005/jp/books/12972_26.

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Murphy, Elaine. "Cognitive and Behavioral Manifestations of Disorders of Homocysteine Metabolism." In Cognitive and Behavioral Abnormalities of Pediatric Diseases. Oxford University Press, 2010. http://dx.doi.org/10.1093/oso/9780195342680.003.0041.

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This chapter reviews the metabolism of homocysteine and its associated defects, focusing on the clinical manifestations of cognitive and behavioral disturbances. The terminology of homocysteine and its derivatives can be confusing, so I begin by clarifying that. Next, the metabolism of homocysteine is outlined, followed by discussion of the disorders of homocysteine transsulfuration. Vitamin B12 (cobalamin, CBL) is important in the effective metabolism of homocysteine and thus defects of CBL absorption, transport, and intracellular transport are also discussed. Finally, disorders of remethylation of methionine will be described. Diagnostic criteria, imaging results, and the pathophysiology of these disorders are also considered. The terminology related to homocysteine metabolism can be confusing. In 2000, a consensus statement on homocysteine nomenclature was published (Mudd et al. 2000). Normal human plasma contains total concentrations of homocysteine and its derivative disulfides of less than 15 μmol/L, although there is some variation due to genetic and other factors. Of this total, only 1%–2% occurs as the thiol (i.e., sulfhydryl) containing amino acid homocysteine. The remaining 98% is in the form of disulfides. Approximately 75%–80% of the total is bound to protein through disulfide bonds with protein cysteines, mainly in albumin, whereas the remainder occurs in non–protein-bound or free forms: the disulfide homocystine-homocystine (Hcy-Hcy), homocysteine-cysteine mixed disulphide, and minor amounts of other mixed disulfides. Together all these moieties make up what is referred to as total homocysteine (tHcy). As all these disulfide bonds can be cleaved by reducing agents, giving the thiol homocysteine, this allows measurement of tHcy as the sum of any thiol homocysteine originally present plus that originally present as a disulfide. In patients with homocystinuria, the percentage contribution of the thiol homocysteine to the total of these forms in plasma rises, reaching 10%–25% as the total homocysteine concentration reaches 150–400 μmol/L. The methionine/homocysteine cycle, also known as the single carbon transfer pathway, is found in all tissues and can broadly be divided into transsulfuration and remethylation components. The cycle aims to conserve methionine and provide sufficient S-adenosylmethionine (AdoMet) for vital transmethylation reactions.
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Cegla, Jaimini, and James Scott. "Lipid disorders." In Oxford Textbook of Medicine, edited by Timothy M. Cox. Oxford University Press, 2020. http://dx.doi.org/10.1093/med/9780198746690.003.0232.

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High blood cholesterol and high blood triglycerides are causal risk factors for atherosclerotic cardiovascular disease, which remains the leading cause of death in the developed world. Lipid and lipoprotein metabolism—cholesterol, triglycerides, and fat-soluble vitamins are transported with specific proteins in the blood as multimeric complexes called lipoproteins. Lipid and lipoprotein metabolism are effected by three principal physiological processes: (1) intestinal absorption of dietary lipid and transport in the blood of dietary lipid and lipids, principally derived from the liver (as triglyceride-rich lipoproteins) to peripheral tissues for catabolism by skeletal and cardiac muscle or storage in adipose tissue; (2) return of triglyceride-rich lipoprotein remnants to the liver, hepatic synthesis of low-density lipoprotein, and the transport of cholesterol between peripheral tissues and the liver; and (3) reverse cholesterol transport by high-density lipoprotein (HDL) between peripheral tissues and the liver. Dyslipidaemias are disorders of lipoprotein metabolism in which there is elevation of total cholesterol and/or triglycerides, often accompanied by reduced levels of HDL cholesterol. Causes of dyslipidaemia—particular lipid disorders including polygenic hypercholesterolaemia, familial hypercholesterolaemia, combined hypercholesterolaemia and hypertriglyceridaemia, familial combined hyperlipidaemia, familial dysbetalipoproteinaemia (also called type 3 hyperlipoproteinaemia), and severe hypertriglyceridaemia, as well as secondary or aggravating factors. Management of dyslipidaemia—the key questions are: (1) what classes of lipoproteins and lipids are increased or decreased in the patient’s plasma? (2) Does the patient has a primary (genetic) or secondary (acquired) dyslipidaemia (often contributions from both influences)? (3) Is the patient at risk of atherosclerotic cardiovascular disease or acute pancreatitis? (4) What other risk factors (e.g. hypertension or diabetes) are present? (5) What treatments might be used to address these abnormalities?
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Veldhuis, Johannes D., Lindsay M. Faunt, and Michael L. Johnson. "[16] Analysis of nonequilibrium dynamics of bound, free, and total plasma ligand concentrations over time following nonlinear secretory inputs: Kinetics of two or more hormones pulsed into compartments containing multiple variable-affinity binding proteins." In Part B: Numerical Computer Methods. Elsevier, 1994. http://dx.doi.org/10.1016/s0076-6879(94)40055-5.

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Conference papers on the topic "Total plasma protein"

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Malm, J., R. Bennhagen, L. Holmberg, and B. Dahlbäck. "LOW PLASMA CONCENTRATIONS OF C4b-BINDING PROTEIN AND VITAMIN K-DEPENDENT PROTEIN S IN PRETERM INFANTS WITH DECREASED FORMATION OF PROTEIN S-C4b-BINDING PROTEIN COMPLEXES." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644265.

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Protein S is a vitamin K-dependent plasmaprotein functioning as a non-enzymatic cofactor to the activated form of protein C in the degradation of coagulationfactors Va and VIIa. In the circulation approximately 60% of protein S is complexed to the complement protein C4b-binding protein (C4BP). Only the remaining, free fraction exhibits protein Ca cofactor activity.The plasma concentrations of protein S and C4BP were determined in 25 term and 26 preterm infants. Both proteins werequantified with radioimmunoassays. The free, functionally active form of proteinS and the total protein S concentrat
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Schwarz, H. P., and W. Muntean. "LOW TOTAL PROTEIN S ANTIGEN BUT HIGH PROTEIN S ACTIVITY DUE TO DECREASED C4b-BINDING PROTEIN (C4b-BP) LEVELS IN NEWBORNS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643610.

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Vitamin K-dependent coagulation proteins are known to be decreased in the neonatal period. So far no data have been published on protein S (PS), the vitamin K-dependent cofactor for the antithrombotic enzyme, activated protein C (APC) in this period. We determined, therefore, PS antigen, PS activity and C4b-BP,a regulatory protein of the classical complement pathway to which PS is complexed, in 36 neonates. Total PS antigen in newborns was below the range associated with thromboembolism in patients congenitally deficient in this protein (22±9.6%, mean±SD). None of these infants had clinical or
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Viganò D'Angelo, S., L. Gugliotta, F. Gilardoni, A. Macagni, L. Chetti, and A. D'Angelo. "PLASMA LEVELS OF PROTEIN S AND C4b-BINDING PROTEIN DURING TREATMENT WITH L-ASPARAGINASE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644292.

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Protein S (PS), the cofactor of activated protein C (PC), circulates in plasma as free PS (active) and in complex with C4b-binding protein (inactive). We have followed the changes of total PS, free PS, PS activity and C4b-binding protein in 5 adult patients with acute lymphoblastic leukemia treated with 20,000 IU/sqm L-asparaginase (L-ASE) administered three times weekly for two weeks (6 doses) and compared them to the changes of PC antigen and activity, antithrombin III and fibrinogen. The table shows the mean values of these parameters (% of pretreatment values) observed after three doses of
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Comp, P. C., and C. T. Esmon. "Defects in the protein C pathway." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643715.

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Activated protein C functions as an anticoagulant by enzymatically degrading factors Va and Villa in the clotting cascade. Protein C may be converted to its enzymatically active form bythrombin. The rate at which thrombin cleavage of the zymogen occurs is greatly enhanced when thrombin is bound to an endothelial cell receptor protein, thrombomodulin. Activated proteinC has a relatively long half-life in vivo and the formation of activated protein C in response to low level thrombin infusion suggests that the protein C system may provide a feedback mechanism to limit blood clotting. Clinical su
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Gadelha-Parente, T., M. Gouault-Heilmann, G. Rostoker, et al. "TOTAL AND FREE PROTEIN S IN NEPHROTIC SYNDROME." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644296.

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25 consecutive patients (15M, 10F ; mean age 30 years) with nephrotic syndrome (NS) of different grade were studied. Control group consisted in 18 healthy adult volunteers. Total protein S antigen (TPS:Ag) and free protein S antigen (FPS:Ag) after precipitation of C4-BP-bound protein S by PEG 3-5 % final concentration were measured by Laurell's technique. PS:Ag was also searched in concentrated urine of 9 patients by ELISA method, more sensitive than the Laurell's technique. In the same plasma samples we measured C4-BP, Protein C Ag and AT III biological activity (all reagents from D.Stago). S
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Vigano D'Angelo, S., F. Gilardoni, M. P. Seveso, A. Marassi, G. Mari, and A. D'Angelo. "REDUCTION OF THE ANTICOAGULANT ACTIVITY OF PROTEIN C AND PROTEIN S DURING THE POSTOPERATIVE PERIOD." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644287.

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Protein S circulates in plasma as free protein S and in complex with C4b-binding protein, an inhibitor of complement activation. Only free protein S functions as the cofactor for the anticoagulant and profibrinolytic effects of activated protein C. Since isolated reductions of protein C and protein S result in increased thrombotic risk, only measurement of both proteins permits comprehensive evaluation of the antithrombotic potential of the protein C system. No information is available on protein C and protein S functional levels during the postoperative period, an established prothrombotic co
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D'Angelo, A., F. Gilardoni, M. P. Seveso, P. Poli, R. Quintavalle, and C. Manotti. "ANTICOAGULANT AND ANTIGENIC LEVELS OF PROTEIN C AND PROTEIN S IN PATIENTS ON STABILIZED ORAL ANTICOAGULANT TREATMENT." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644286.

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Isolated deficiencies of protein C and protein S, two vitamin K-dependent plasma proteins, constitute about 70% of the congenital abnormalities of blood coagulation observed in patients with recurrent venous thrombosis beLow the age of 40. The laboratory diagnosis of congenital deficiency of these proteins represents a major problem since a large proportion of patients are on oral anticoagulation (OA) at the time the deficiencies are suspected.Under these circumstances the availability of a reference interval obtained in patients on stabilized OA has proven useful.Functional (C) and antigenic
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D'Angelo, A., F. Gilardoni, V. Toschi, C. Ciminiello, E. A. Sinico, and S. Viganò D'Angelo. "REDUCED PROTEIN S ANTICOAGULANT ACTIVITY IN ESSENTIAL MIXED CRYOGLOBULINEMIA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644293.

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Abstract:
Protein S (PS) is found in two forms in plasma, as free PS, which functions as a cofactor for activated protein C, and in e-quimolar complex with C4b-binding protein (C4b-bp), an inhibitor of the complement system. The Kd of the PS-C4b-bp interaction is one order of magnitude lower than the plasma concentration of the two proteins; thus 55-60% of total PS circulates in the bound form. Evidence has been provided that in vitro complement activation does not affect the equilibrium between PS and C4b-bp; however in patients with systemic lupus erythematosus and low C4 levels, a shift from free to
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Wilkinson, J. M., N. Hack, L. I. Thorsen, and J. A. Thomas. "MONOCLONAL ANTIBODIES RECOGNISING PROTEINS OF THE OUTER AND INNER SURFACE OF THE PLATELET PLASMA MEMBRANE." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644493.

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Abstract:
Platelet membrane preparations can be fractionated into two major subpopulations by free flow electrophoresis and these have been shown to correspond to the plasma membrane and the endoplasmic reticulum of the platelet. The plasma membrane fraction can be shown, by two-dimensional electrophoresis, to contain the major surface glycoproteins together with considerable amounts of actin and actin-associated proteins such as the 250 kDa actin-binding protein (filamin), P235 (talin), myosin, α-actinin and tropomyosin (Hack, N. … Crawford, N., Biochem. J. 222, 235 (1984). These cytoskeletal proteins
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10

Laurell, M., T. Carlsson, and J. Stenflo. "IMMUNOAFFINITY PURIFICATION OF PLASMA INHIBITOR FOR ACTIVATED PROTEIN C." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643814.

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Abstract:
Activated protein C (APC) is an important regulator of blood coagulation in vivo. In plasma this serine protease is slowly inhibited by a specific inhibitor, activated protein C inhibitor (PCI), (Suzuki et al. (1983) J.Biol.Chem. 258 , 163-168). We have now made monoclonal antibodies against PCI by immunizing with the APC-PCI complex. Positive clones were identified by solid phase immunoassay with 125I labelled partially purified inhibitor. After subcloning and expansion in mice, one of the monoclonal antibodies was immobilized on Sepharose 4B and used in the purification of the inhibitor. A t
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