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1

Lyon, Gholson J., David Shprecher, Barbara Coffey, and Roger Kurlan. "Tourette’s Disorder." Current Treatment Options in Neurology 12, no. 4 (May 13, 2010): 274–86. http://dx.doi.org/10.1007/s11940-010-0073-x.

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2

Karim, Muhammad Enayeth, Zeenat Parvin Ruhie, Kazi Dider A. Mostofa, Mohammad Shafiul Islam, and Susmita Roy. "Tourette’s disorder and obsessive compulsive disorder: a case report." Bangladesh Journal of Psychiatry 31, no. 1 (February 6, 2020): 24–26. http://dx.doi.org/10.3329/bjpsy.v31i1.45369.

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Tourette’s disorder is a childhood onset neuropsychiatric disorder characterized by multiple motor and vocal tics for at least one year in duration. Occasionally this disorder may be associated with obsessive compulsive disorder. This case was presented here to demonstrate the co-occurrence of these two disorders as well as the effectiveness of pharmacological treatment for the improvement of the condition. The case report described the history of a 21 years old male patient with 7 years history of Tourette’s disorder and obsessive compulsive disorder. He was seriously disabled by his symptoms that necessitated thorough evaluation to exclude causes, differential diagnoses and or any other co morbidities. Treatment with fluoxetine 60 mg daily and quitiapine 100 mg daily in divided dose improved his symptoms and he was able to return his functional life, that he had been mislaid because of his illness. Bang J Psychiatry June 2017; 31(1): 24-26
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3

Bloch, Michael H. "Emerging treatments for Tourette’s disorder." Current Psychiatry Reports 10, no. 4 (August 2008): 323–30. http://dx.doi.org/10.1007/s11920-008-0052-z.

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4

Cunningham, Annelise, and Kimberly Renk. "I’m Uncomfortable, You’re Uncomfortable, We’re Uncomfortable: An Integrative Family Approach to the Treatment of Tourette’s Disorder and Separation Anxiety Disorder in a Young Child." Clinical Case Studies 16, no. 6 (September 21, 2017): 446–63. http://dx.doi.org/10.1177/1534650117732143.

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This case study follows a 6-year old Caucasian Hispanic male who presented with symptoms of Tourette’s disorder and separation anxiety disorder. Given the young age of the child, a critical focus was placed on parental involvement and parental mastery of the treatment components within an attachment-focused conceptualization as the foundation for all treatment delivery. To address all issues presented by the family of this young child, a behavioral treatment was utilized to target symptoms of Tourette’s disorder, and components of cognitive-behavioral therapy were used to address symptoms associated with separation anxiety disorder (in the young child). Further, components of an attachment-based parenting program, Circle of Security–Parenting, were inserted throughout treatment to keep this young child’s parents in tune with their relationship with their young child. Following completion of treatment, this young child displayed significant decreases in his symptoms across both disorders. Further, this young child and his parents demonstrated a mastery of treatment concepts and coping skills. The family reported both qualitative and quantitative improvements in the young child’s overall emotional and behavioral functioning. This study displayed the effectiveness of an integrative family-based approach in the treatment of a young child with symptoms of both Tourette’s disorder and separation anxiety disorder.
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5

Hussain, Humaira. "PRESENCE OF DYSPHONIA IN INDIVIDUALS WITH TOURETTE’S SYNDROME." Pakistan Journal of Rehabilitation 4, no. 1 (January 10, 2015): 42–47. http://dx.doi.org/10.36283/pjr.zu.4.1/009.

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Professionals working in the field of voice disorders have come to recognize the variability of vocal qualities in different populations. While voice disorders can be of organic, neurogenic, or functional etiology, concomitant disorders often directly impact the vocal features. Such a disorder is Tourette’s Syndrome which is an impairment characterized by motor and vocal tics. This study examined the prevalence of voice disorders in individuals with Tourette’s Syndrome. Research was conducted over the duration of two years with clientele aged 15;2 to 26;5. Participants were receiving continuous treatment from a team of neurologist and psychologist at private clinics situated around a suburban area. Two case studies consisting of 1-2 individuals were also closely examined to further distinguish the types of voice disorders present given the severity of motor and vocal tics. Instrumental and perceptual analysis was obtained to accurately diagnose the voice disorder. Given the sample of participants, presence of spasmodic dysphonia and falsetto were noted. Results of this study indicates a strong presence of dysphonia in individuals with Tourette’s Syndrome, particularly spasmodic dysphonia and falsetto. Additionally, dysphonic vocal qualities were irrelevant to the existence of vocal tics. Further research with this population is mandated to determine assessment and treatment strategies
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6

Dell’Osso, Bernardo, Humberto Nicolini, Nuria Lanzagorta, Beatrice Benatti, Gregorio Spagnolin, M. Carlotta Palazzo, Donatella Marazziti, et al. "Cigarette smoking in patients with obsessive compulsive disorder: a report from the International College of Obsessive Compulsive Spectrum Disorders (ICOCS)." CNS Spectrums 20, no. 5 (September 9, 2015): 469–73. http://dx.doi.org/10.1017/s1092852915000565.

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Obsessive compulsive disorder (OCD) showed a lower prevalence of cigarette smoking compared to other psychiatric disorders in previous and recent reports. We assessed the prevalence and clinical correlates of the phenomenon in an international sample of 504 OCD patients recruited through the International College of Obsessive Compulsive Spectrum Disorders (ICOCS) network.Cigarette smoking showed a cross-sectional prevalence of 24.4% in the sample, with significant differences across countries. Females were more represented among smoking patients (16% vs 7%; p<.001). Patients with comorbid Tourette’s syndrome (p<.05) and tic disorder (p<.05) were also more represented among smoking subjects. Former smokers reported a higher number of suicide attempts (p<.05).We found a lower cross-sectional prevalence of smoking among OCD patients compared to findings from previous studies in patients with other psychiatric disorders but higher compared to previous and more recent OCD studies. Geographic differences were found and smoking was more common in females and comorbid Tourette’s syndrome/tic disorder.
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7

Greydanus, Donald E., and Julia Tullio. "Tourette’s disorder in children and adolescents." Translational Pediatrics 9, S1 (February 2020): S94—S103. http://dx.doi.org/10.21037/tp.2019.09.11.

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8

Buzan, Randall D., Jay H. Shore, Christopher O’Brien, and Christopher Schneck. "Obsessive-compulsive disorder and Tourette’s syndrome." Current Treatment Options in Neurology 2, no. 2 (March 2000): 125–39. http://dx.doi.org/10.1007/s11940-000-0014-1.

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9

Calder-Sprackman, Samantha, Stephanie Sutherland, and Asif Doja. "The Portrayal of Tourette Syndrome in Film and Television." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 41, no. 2 (March 2014): 226–32. http://dx.doi.org/10.1017/s0317167100016620.

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Objective:To determine the representation of Tourette Syndrome (TS) in fictional movies and television programs by investigating recurrent themes and depictions.Background:Television and film can be a source of information and misinformation about medical disorders. Tourette Syndrome has received attention in the popular media, but no studies have been done on the accuracy of the depiction of the disorder.Methods:International internet movie databases were searched using the terms “Tourette’s”, “Tourette’s Syndrome”, and “tics” to generate all movies, shorts, and television programs featuring a character or scene with TS or a person imitating TS. Using a grounded theory approach, we identified the types of characters, tics, and co-morbidities depicted as well as the overall representation of TS.Results:Thirty-seven television programs and films were reviewed dating from 1976 to 2010. Fictional movies and television shows gave overall misrepresentations of TS. Coprolalia was overrepresented as a tic manifestation, characters were depicted having autism spectrum disorder symptoms rather than TS, and physicians were portrayed as unsympathetic and only focusing on medical therapies. School and family relationships were frequently depicted as being negatively impacted by TS, leading to poor quality of life.Conclusions:Film and television are easily accessible resources for patients and the public that may influence their beliefs about TS. Physicians should be aware that TS is often inaccurately represented in television programs and film and acknowledge misrepresentations in order to counsel patients accordingly.
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10

Essoe, Joey Ka-Yee, Marco A. Grados, Harvey S. Singer, Nicholas S. Myers, and Joseph F. McGuire. "Evidence-based treatment of Tourette’s disorder and chronic tic disorders." Expert Review of Neurotherapeutics 19, no. 11 (July 17, 2019): 1103–15. http://dx.doi.org/10.1080/14737175.2019.1643236.

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11

MUNASIPOVA, S. E., Z. A. ZALYALOVA, and D. M. KHASANOVA. "Comorbidity of tic hyperkineses with impulsive disorders." Practical medicine 18, no. 5 (2020): 88–92. http://dx.doi.org/10.32000/2072-1757-2020-5-88-92.

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Tourette’s syndrome, the most common cause of tics, manifests itself in a wide range of motor and behavioral disorders and is found in men about three times more often than in women. The purpose — to establish the comorbidity of neuropsychiatric disorders in patients with tic hyperkinesis. Material and methods. The study included 111 patients with tic hyperkinesis of various ages and sex, who were outpatiently observed at the Clinical and Diagnostic Center for Movement Disorders and Botulinum Therapy of the Republic of Tatarstan from 2011 to 2014. Results and conclusions. In the group of patients we studied, tics were more common in males (in 71.6% of cases), and patients with Tourette’s syndrome were numerically predominant, taking into account the visits to the Clinical and Diagnostic Center for Movement Disorders and Botulinum Therapy of the Republic of Tatarstan. Clinical manifestations of obsessive-compulsive disorders were found not only in patients with Tourette’s syndrome, but they are characteristic of 53.2% of patients with tic hyperkinesis of various severity and phenomenology. Also, regardless of the structural and phenomenological characteristics of tic hyperkinesis, they were almost always associated with attention deficit hyperactivity disorder with a predominance of hyperactivity.
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12

Essoe, Joey Ka-Yee, Kesley A. Ramsey, Harvey S. Singer, Marco Grados, and Joseph F. McGuire. "Mechanisms Underlying Behavior Therapy for Tourette’s Disorder." Current Developmental Disorders Reports 8, no. 3 (February 24, 2021): 161–74. http://dx.doi.org/10.1007/s40474-021-00225-1.

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13

Soltanifar, A., R. Lashkarnevis, M. Ziaee, R. Samadi, A. Soltanifar, and M. Kamrani. "Aripiprazole or Risperidone for Tourette’s Disorder in Children and Adolescents? Efficacy and Impact on Weight Comparative study of therapeutic efficacy and body mass index of risperidone and Aripiprazole in children and adolescents with Tourette’s syndrome." Pakistan Journal of Medical and Health Sciences 15, no. 5 (May 30, 2021): 1564–70. http://dx.doi.org/10.53350/pjmhs211551564.

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Introduction: Due to the high prevalence of Tourette’s disorder among children and adolescents and its negative consequences, an appropriate and effective medical treatment with minimal complications is necessary. Therefore, this study was conducted to compare the effects of Aripiprazole and Risperidone on Tourette’s disorders in both children and adolescents. Method: The statistical population of this clinical trial was children and adolescents aged from seven to eighteen years old. They were diagnosed with the Tourette’s disorders based on the DSM-V criteria by the clinical interview of a child and adolescent psychiatrist in the child Psychiatry clinic of Ibn-e-Sina's Psychiatric Hospital (Mashhad-Iran) in 2018. A total of forty participants were selected by the convenience sampling method, and they were randomly divided into two groups treated by medicines, named as Risperidone or Aripiprazole for two months. Then, the demographic information questionnaire was completed. The Y-GTSS Scale was completed. Clinical Effect Rating Scale (CGI-Tics Scale) was completed. Calculation of body mass index and medical side effects complications were completed. The evaluation was carried out both at the beginning and on second, fourth and eighth weeks, and the results were compared. The data were analyzed by SPSS software (version 14) through using descriptive statistics, chi-square, and variance analysis. Results: The two groups were homogeneous for demographic variables. There was no significant difference in BMI between the two groups. Despite the positive effect of both medicines, no significant difference was observed among the general scores of such disorders, the overall score of severity, Tourette’s recovery, and BMI of these two groups at the intervals and at the end of treatments. (p <0.05). Due to the low number of complications reported, statistical comparisons of the medical side effects were not done for us Conclusion: According to the results, it seems that the two medicines, Aripiprazole and Risperidone, were effective in improving the symptoms of Tourette’s disorders and its overall severity. However, there was no significant statistical differences between them. In terms of the medical side effects, the statistical comparison between the two medicines was not possible due to the small number of complications. Keywords: tic, Tourette’s syndrome, Aripiprazole, Risperidone
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14

Roessner, Veit, Pieter J. Hoekstra, and Aribert Rothenberger. "Tourette’s disorder and other tic disorders in DSM-5: a comment." European Child & Adolescent Psychiatry 20, no. 2 (November 13, 2010): 71–74. http://dx.doi.org/10.1007/s00787-010-0143-3.

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15

Wendt, Frank R., Gita A. Pathak, Daniel S. Tylee, Aranyak Goswami, and Renato Polimanti. "Heterogeneity and Polygenicity in Psychiatric Disorders: A Genome-Wide Perspective." Chronic Stress 4 (January 2020): 247054702092484. http://dx.doi.org/10.1177/2470547020924844.

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Genome-wide association studies (GWAS) have been performed for many psychiatric disorders and revealed a complex polygenic architecture linking mental and physical health phenotypes. Psychiatric diagnoses are often heterogeneous, and several layers of trait heterogeneity may contribute to detection of genetic risks per disorder or across multiple disorders. In this review, we discuss these heterogeneities and their consequences on the discovery of risk loci using large-scale genetic data. We primarily highlight the ways in which sex and diagnostic complexity contribute to risk locus discovery in schizophrenia, bipolar disorder, attention deficit hyperactivity disorder, autism spectrum disorder, posttraumatic stress disorder, major depressive disorder, obsessive-compulsive disorder, Tourette’s syndrome and chronic tic disorder, anxiety disorders, suicidality, feeding and eating disorders, and substance use disorders. Genetic data also have facilitated discovery of clinically relevant subphenotypes also described here. Collectively, GWAS of psychiatric disorders revealed that the understanding of heterogeneity, polygenicity, and pleiotropy is critical to translate genetic findings into treatment strategies.
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16

Sulkowski, Michael L., Joseph F. McGuire, and Andrew Tesoro. "Treating Tics and Tourette’s Disorder in School Settings." Canadian Journal of School Psychology 31, no. 1 (August 26, 2015): 47–62. http://dx.doi.org/10.1177/0829573515601820.

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17

McGuire, Joseph F., Nathaniel Ginder, Kesley Ramsey, Joey Ka-Yee Essoe, Emily J. Ricketts, James T. McCracken, and John Piacentini. "Optimizing behavior therapy for youth with Tourette’s disorder." Neuropsychopharmacology 45, no. 12 (July 12, 2020): 2114–19. http://dx.doi.org/10.1038/s41386-020-0762-4.

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18

Steingard, Ronald, and Donna Dillon-Stout. "Tourette’s Syndrome and Obsessive Compulsive Disorder: Clinical Aspects." Psychiatric Clinics of North America 15, no. 4 (December 1992): 849–60. http://dx.doi.org/10.1016/s0193-953x(18)30213-2.

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19

Nunes, Fernanda T., and Lisieux E. B. Telles. "Tourette’s disorder and sexual offenses: psychiatric-forensic considerations." Brazilian Journal of Psychiatry 41, no. 4 (August 2019): 364–65. http://dx.doi.org/10.1590/1516-4446-2019-0420.

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20

McGuire, Joseph, John Piacentini, and Joseph McGuire. "Managing Tics and Tourette’s Disorder Using Behavior Therapy." Journal of the American Academy of Child & Adolescent Psychiatry 57, no. 10 (October 2018): S335—S336. http://dx.doi.org/10.1016/j.jaac.2018.07.850.

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21

Darrow, Sabrina M., Marco Grados, Paul Sandor, Matthew E. Hirschtritt, Cornelia Illmann, Lisa Osiecki, Yves Dion, et al. "Autism Spectrum Symptoms in a Tourette’s Disorder Sample." Journal of the American Academy of Child & Adolescent Psychiatry 56, no. 7 (July 2017): 610–17. http://dx.doi.org/10.1016/j.jaac.2017.05.002.

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22

Wilkinson, Berney J., Richard M. Marshall, and Brenda Curtwright. "Impact of Tourette’s Disorder on Parent Reported Stress." Journal of Child and Family Studies 17, no. 4 (October 30, 2007): 582–98. http://dx.doi.org/10.1007/s10826-007-9176-8.

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23

Storch, Eric A., Lisa J. Merlo, Heather Lehmkuhl, Kristen M. Grabill, Gary R. Geffken, Wayne K. Goodman, and Tanya K. Murphy. "Further Psychometric Examination of the Tourette’s Disorder Scales." Child Psychiatry and Human Development 38, no. 2 (November 29, 2006): 89–98. http://dx.doi.org/10.1007/s10578-006-0043-4.

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24

Lewis, Kendra, Leonard Rappa, Devon A. Sherwood-Jachimowicz, and Margareth Larose-Pierre. "Aripiprazole for the Treatment of Adolescent Tourette’s Syndrome." Journal of Pharmacy Practice 23, no. 3 (March 31, 2010): 239–44. http://dx.doi.org/10.1177/0897190009358771.

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Gilles de la Tourette syndrome (GTS) is a neuropsychiatric, lifelong disorder with onset in childhood. The essential features of this disorder are multiple motor tics and one or more vocalizations. The neurochemical pathophysiology of GTS involves an unknown abnormality in the central dopaminergic system. Atypical antipsychotics, such as aripiprazole, serve as a new therapeutic option for GTS. The authors describe a unique case of Tourette’s syndrome (TS) in an adolescent in which aripiprazole resolved the patient’s symptoms. A 17-year-old, 5′11′′ tall, African American male weighing 220 lbs was diagnosed with TS at 9 years old. By age 16, the patient developed prominent symptoms of intermitted eye blinking, forehead raising, finger snapping, heavy breathing, and head bobbing. Clonidine, in addition to homeopathic remedies ( N-acetylcholine and alpha lipoic acid), was administered to the patient without significant diminution of symptoms. Later, aripiprazole was initiated at 5 mg/d. As a result, noticeable symptomatic improvement occurred within 48 hours. Aripiprazole was titrated over the next 4 weeks to 6.5 mg/d, with significant results. Over the next 6 months, aripiprazole was titrated again to 10 mg/d with additional symptom reduction. This case illustrates a patient who responded to aripiprazole with no reported adverse effects, when standard therapy failed to improve symptoms.
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25

McGuire, Joseph, Nathaniel Ginder, James T. McCracken, and John Piacentini. "4.4 Optimizing Therapeutic Outcomes for Youth With Tourette’s Disorder." Journal of the American Academy of Child & Adolescent Psychiatry 57, no. 10 (October 2018): S275. http://dx.doi.org/10.1016/j.jaac.2018.07.638.

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26

Kim, Woo Hyun, Tae Won Park, Juhyun Park, Sang-Keun Chung, Jong-Chul Yang, Jong-Il Park, Eun-Ji Kim, Eun-Cheong Cho, and Jae Cheol Park. "Comparing Intelligence Test Profiles to Assess Tourette’s Disorder with Attention-Deficit Hyperactivity Disorder." Journal of the Korean Academy of Child and Adolescent Psychiatry 28, no. 1 (January 1, 2017): 25–30. http://dx.doi.org/10.5765/jkacap.2017.28.1.25.

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27

Fan, Siyan, Danielle C. Cath, Ysbrand D. van der Werf, Stella de Wit, Dick J. Veltman, and Odile A. van den Heuvel. "Trans-diagnostic comparison of response inhibition in Tourette’s disorder and obsessive-compulsive disorder." World Journal of Biological Psychiatry 19, no. 7 (July 25, 2017): 527–37. http://dx.doi.org/10.1080/15622975.2017.1347711.

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28

Montalbano, G. E., M. Rozenman, T. Peris, P. Tan, J. Piacentini, and E. Ricketts. "0997 The Sleep Disturbance Scale For Children In Youth With Tourette’S Disorder." Sleep 43, Supplement_1 (April 2020): A378—A379. http://dx.doi.org/10.1093/sleep/zsaa056.993.

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Abstract Introduction Sleep disturbance is common in youth with Persistent Tic Disorders (PTDs), including Tourette’s Disorder. However, studies elucidating the nature of sleep problems in PTDs are limited. The present study examines the types of sleep disturbance present in youth with PTDs relative to healthy controls, and investigates the relationship between sleep disturbance and tic severity. Methods Participants were 56 youth ages 8 to 17 (M=11.9, SD=2.86), including individuals with PTDs (n=27), and healthy controls (n=29). An interviewer evaluated psychiatric diagnosis using the Anxiety Disorders Interview Schedule, and tic severity using the Yale Global Tic Severity Scale (YGTSS). Parents rated sleep using the Sleep Disturbance Scale for Children (SDSC), and tic severity using the Parent Tic Questionnaire (PTQ). Independent-samples t-tests and bivariate correlations were performed. Results Higher SDSC Total scores, t(30)=-3.74, p=.001) were found in youth with PTDs relative to healthy controls. Youth with PTDs endorsed elevated sleep disturbance with respect to: Disorders of Initiating and Maintaining Sleep, t(35)=-2.43, p=.02), Sleep-Wake Transition Disorders, t(37)=-3.04, p=.004), and Disorders of Excessive Somnolence, t(33)=-2.36, p=.02). No significant group differenceswere shown for Sleep Breathing Disorders, Disorders of Arousal, and Sleep Hyperhydrosis. There was a positive association between SDSC Total scores and YGTSS Total (p=.01, r=.56) and YGTSS Impairment scores (p= .03, r=.33). Finally, there was a positive relationship between SDSC Total and PTQ Total scores (p=.01, r=.61). Conclusion Findings suggest youth with PTDs are more likely to experience sleep disturbance than healthy children, particularly difficulties with sleep initiation and maintenance, abnormal movements during sleep, and daytime sleepiness. Further, there is a relationship between sleep disturbance and tic severity. Findings highlight the need for sleep screening and targeted sleep intervention in youth with PTDs. Support N/A
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29

Gardner, Marcia Rubenstein. "Understanding and Caring for the Child With Asperger Syndrome." Journal of School Nursing 17, no. 4 (August 2001): 178–84. http://dx.doi.org/10.1177/10598405010170040201.

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Nurses in a variety of settings encounter children with the unfamiliar diagnosis of Asperger syndrome (AS). This disorder, which falls clinically along the autism spectrum, is receiving increasing attention because of its inclusion in the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) as one of the pervasive developmental disorders. The characteristic features of AS include deficits in social skills, atypical understanding of and use of pragmatic language, behavior problems, and a restricted set of interests. Cognitive abilities vary, and some children with AS have high intelligence. In addition, many children with AS have other conditions, such as attention deficit hyperactivity disorder, Tourette’s syndrome, obsessive-compulsive disorder, and depression. The disorder can result in significant functional difficulties in the home, school, and community contexts. A case study highlights the features of AS, and a related individualized school health care plan demonstrates the school nurse’s role in family and staff education, monitoring for comorbidities, behavioral management, medication management, support to family members, and referral.
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Nam, Seok Hyun, Juhyun Park, and Tae Won Park. "Clinical Aspects of Premonitory Urges in Patients with Tourette’s Disorder." Journal of the Korean Academy of Child and Adolescent Psychiatry 30, no. 2 (April 1, 2019): 50–56. http://dx.doi.org/10.5765/jkacap.180025.

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31

Charania, Sana N., Melissa Danielson, Rebecca Bitsko, Angelika Claussen, and Lydie A. Leburn-Harris. "2.51 BULLYING VICTIMIZATION AND PERPETRATION AMONG CHILDREN WITH TOURETTE’S DISORDER." Journal of the American Academy of Child & Adolescent Psychiatry 58, no. 10 (October 2019): S187. http://dx.doi.org/10.1016/j.jaac.2019.08.143.

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32

Joung, Yoo-Sook, and Moon-Soo Lee. "The therapeutic approaches in children and adolescent with Tourette’s disorder." Precision and Future Medicine 5, no. 1 (March 31, 2021): 21–30. http://dx.doi.org/10.23838/pfm.2020.00191.

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33

Berthier, Marcelo L., Jaime Kulisevsky, and Víctor M. Campos. "Bipolar Disorder in Adult Patients with Tourette’s Syndrome: A Clinical Study." Biological Psychiatry 43, no. 5 (March 1998): 364–70. http://dx.doi.org/10.1016/s0006-3223(97)00025-5.

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34

Jakušić, Nenad, and Aleksandra Klobučar. "Holistic approach in the treatment of a boy with Tourette’s disorder." Paediatria Croatica 59, no. 1 (March 30, 2015): 51–54. http://dx.doi.org/10.13112/pc.2015.10.

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35

Haddad, A. D. M., G. Umoh, V. Bhatia, and M. M. Robertson. "Adults with Tourette’s syndrome with and without attention deficit hyperactivity disorder." Acta Psychiatrica Scandinavica 120, no. 4 (September 10, 2009): 299–307. http://dx.doi.org/10.1111/j.1600-0447.2009.01398.x.

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36

Rankins, D., J. L. Bradshaw, and N. Georgiou-Karistianis. "Local–global processing in obsessive–compulsive disorder and comorbid Tourette’s syndrome." Brain and Cognition 59, no. 1 (October 2005): 43–51. http://dx.doi.org/10.1016/j.bandc.2005.04.003.

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37

Rankins, D., J. L. Bradshaw, and N. Georgiou-Karistianis. "The semantic Simon effect in Tourette’s syndrome and obsessive-compulsive disorder." Brain and Cognition 61, no. 3 (August 2006): 225–34. http://dx.doi.org/10.1016/j.bandc.2006.01.002.

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38

Zago, Stefano, Adriana Delli Ponti, Silvia Mastroianni, Federica Solca, Emanuele Tomasini, Barbara Poletti, Silvia Inglese, Giuseppe Sartori, and Mauro Porta. "Counterfactual Thinking in Tourette’s Syndrome: A Study Using Three Measures." Behavioural Neurology 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/256089.

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Pathophysiological evidence suggests an involvement of frontostriatal circuits in Tourette syndrome (TS) and cognitive abnormalities have been detected in tasks sensitive to cognitive deficits associated with prefrontal damage (verbal fluency, planning, attention shifting, working memory, cognitive flexibility, and social reasoning). A disorder in counterfactual thinking (CFT), a behavioural executive process linked to the prefrontal cortex functioning, has not been investigated in TS. CFT refers to the generation of a mental simulation of alternatives to past factual events, actions, and outcomes. It is a pervasive cognitive feature in everyday life and it is closely related to decision-making, planning, problem-solving, and experience-driven learning—cognitive processes that involve wide neuronal networks in which prefrontal lobes play a fundamental role. Clinical observations in patients with focal prefrontal lobe damage or with neurological and psychiatric diseases related to frontal lobe dysfunction (e.g., Parkinson’s disease, Huntington’s disease, and schizophrenia) show counterfactual thinking impairments. In this work, we evaluate the performance of CFT in a group of patients with Tourette’s syndrome compared with a group of healthy participants. Overall results showed no statistical differences in counterfactual thinking between TS patients and controls in the three counterfactual measures proposed. The possible explanations of this unexpected result are discussed below.
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39

Morrison, Kate L., and Michael P. Twohig. "A Functional and Cohesive Treatment of Tourette’s Disorder and Chewing Tobacco Use." Clinical Case Studies 15, no. 2 (August 16, 2015): 103–16. http://dx.doi.org/10.1177/1534650115599442.

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40

Meidinger, Amy L., Raymond G. Miltenberger, Michael Himle, Matthew Omvig, Casey Trainor, and Ross Crosby. "An Investigation of Tic Suppression and the Rebound Effect in Tourette’s Disorder." Behavior Modification 29, no. 5 (September 2005): 716–45. http://dx.doi.org/10.1177/0145445505279262.

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41

Sims, Anthony, and Brendan Stack. "Tourette’s Syndrome: A Pilot Study for the Discontinuance of a Movement Disorder." CRANIO® 27, no. 1 (January 2009): 11–18. http://dx.doi.org/10.1179/crn.2009.003.

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42

Storch, Eric A., Vanessa Milsom, Caleb W. Lack, Steven L. Pence, Gary R. Geffken, Marni L. Jacob, Wayne K. Goodman, and Tanya K. Murphy. "Sleep-Related Problems in Youth with Tourette’s Syndrome and Chronic Tic Disorder." Child and Adolescent Mental Health 14, no. 2 (May 2009): 97–103. http://dx.doi.org/10.1111/j.1475-3588.2008.00497.x.

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43

Pauls, David L. "The Genetics of Obsessive Compulsive Disorder and Gilles De La Tourette’s Syndrome." Psychiatric Clinics of North America 15, no. 4 (December 1992): 759–66. http://dx.doi.org/10.1016/s0193-953x(18)30206-5.

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44

Wilhelm, Sabine, Thilo Deckersbach, Barbara J. Coffey, Antje Bohne, Alan L. Peterson, and Lee Baer. "Habit Reversal Versus Supportive Psychotherapy for Tourette’s Disorder: A Randomized Controlled Trial." American Journal of Psychiatry 160, no. 6 (June 2003): 1175–77. http://dx.doi.org/10.1176/appi.ajp.160.6.1175.

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45

Tudor, Megan E., Emilie Bertschinger, Justyna Piasecka, and Denis G. Sukhodolsky. "Cognitive Behavioral Therapy for Anger and Aggression in a Child With Tourette’s Syndrome." Clinical Case Studies 17, no. 4 (July 12, 2018): 220–32. http://dx.doi.org/10.1177/1534650118782438.

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Tourette syndrome (TS) is a neurodevelopmental disorder that is characterized by vocal and motor tics. Children with TS often also exhibit disruptive behaviors including sudden anger outbursts accompanied by verbal and physical aggression. This case study presents cognitive behavioral therapy (CBT) treatment of anger and aggression in a 9-year-old girl with TS, co-occurring generalized anxiety disorder (GAD), and oppositional defiant disorder (ODD). At initial assessment, tics were well-managed and disruptive behavior concerns, including near-daily tantrums lasting 20 min to 1 hr, were primary clinical concerns. The child and her mother received 12 weekly sessions of CBT for anger and aggression, with select supplements and modifications that related to the context of TS. Posttreatment assessment indicated a significant decrease in noncompliance, anger outbursts, and aggressive behavior. CBT for anger and aggression can be a useful treatment for the disruptive behaviors that often co-occur with TS.
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Forde, N., M. P. Zwiers, J. Naaijen, S. E. A. Akkermans, T. Openneer, A. Dietrich, J. K. Buitelaar, and P. J. Hoekstra. "Basal ganglia structure in Tourette’s disorder and attention deficit hyperactivity disorder: influence of comorbidity and medication use." European Neuropsychopharmacology 26 (October 2016): S315—S316. http://dx.doi.org/10.1016/s0924-977x(16)31224-x.

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47

Fan, Siyan, Danielle C. Cath, Odile A. van den Heuvel, Ysbrand D. van der Werf, Caroline Schöls, Dick J. Veltman, and Petra J. W. Pouwels. "Abnormalities in metabolite concentrations in tourette’s disorder and obsessive-compulsive disorder—A proton magnetic resonance spectroscopy study." Psychoneuroendocrinology 77 (March 2017): 211–17. http://dx.doi.org/10.1016/j.psyneuen.2016.12.007.

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Suyeon Kim and Jinkook Tak. "Analyses of Psychological Stress and Coping of Parents of Children with Tourette’s Disorder." Korean Journal of Health Psychology 25, no. 1 (January 2020): 153–85. http://dx.doi.org/10.17315/kjhp.2020.25.1.009.

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Cortese, Samuele, Michel Lecendreux, Bernardo Dalla Bernardina, Marie Christine Mouren, Andrea Sbarbati, and Eric Konofal. "Attention-deficit/hyperactivity disorder, Tourette’s syndrome, and restless legs syndrome: The iron hypothesis." Medical Hypotheses 70, no. 6 (January 2008): 1128–32. http://dx.doi.org/10.1016/j.mehy.2007.10.013.

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50

Bryson, W. Jeff, Christopher L. Edwards, David B. Sommer, and Burton L. Scott. "Integrated Behavior Therapy in the Treatment of Complicated Tourette’s Disorder and Its Comorbidities." Clinical Case Studies 9, no. 2 (February 25, 2010): 154–63. http://dx.doi.org/10.1177/1534650109357929.

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