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1

Srinivasan, Sanjay, and Elin Lee. "Toxic optic neuropathy." Indian Journal of Ophthalmology 60, no. 2 (2012): 159. http://dx.doi.org/10.4103/0301-4738.94065.

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2

Sharma, Reena, and Pradeep Sharma. "Toxic optic neuropathy." Indian Journal of Ophthalmology 59, no. 2 (2011): 137. http://dx.doi.org/10.4103/0301-4738.77035.

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3

Kesler, Anat, and Pazit Pianka. "Toxic optic neuropathy." Current Neurology and Neuroscience Reports 3, no. 5 (2003): 410–14. http://dx.doi.org/10.1007/s11910-003-0024-y.

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4

Constantin, Farah Sunnar, Monica Irina Ion, and Andrei Erol Constantin. "Tobacco-Alcohol Toxic Optic Neuropathy." romanian journal of ophthalmology 63, no. 4 (2019): 403–5. http://dx.doi.org/10.22336/rjo.2019.65.

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5

Libershteyn, Yevgeniya. "Ethambutol/Linezolid Toxic Optic Neuropathy." Optometry and Vision Science 93, no. 2 (2016): 211–17. http://dx.doi.org/10.1097/opx.0000000000000783.

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6

Teus, Miguel A., José L. Teruel, Julio Pascual, and Eduardo Martin-Escobar. "Corticosteroid-induced Toxic Optic Neuropathy." American Journal of Ophthalmology 112, no. 5 (1991): 605–6. http://dx.doi.org/10.1016/s0002-9394(14)76873-4.

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7

Kulkarni, K. "Linezolid induced toxic optic neuropathy." British Journal of Ophthalmology 89, no. 12 (2005): 1664–65. http://dx.doi.org/10.1136/bjo.2005.074237.

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8

Ostroumova, O. D., E. V. Chikh, E. V. Rebrova, A. Y. Ryazanova, G. Sh Arzhimatova, and L. K. Moshetova. "Drug-induced toxic optic neuropathy." Vestnik oftal'mologii 136, no. 4 (2020): 156. http://dx.doi.org/10.17116/oftalma2020136041156.

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9

Samarakoon, Nadeeka, Brian Harrisberg, and Jonathan Ell. "Ciprofloxacin-induced toxic optic neuropathy." Clinical & Experimental Ophthalmology 35, no. 1 (2007): 102–4. http://dx.doi.org/10.1111/j.1442-9071.2007.01427.x.

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10

Gundogan, Fatih C., Ebru Gorgun, Oguzhan Oz, Fatih M. Mutlu, Gungor Sobaci, and Suat Karagul. "Toluene Related Toxic Optic Neuropathy." Neuro-Ophthalmology 33, no. 5 (2009): 248–52. http://dx.doi.org/10.3109/01658100902998757.

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11

Gundogan, Fatih, Ebru Gorgun, Oguzhan Oz, Fatih Mutlu, Gungor Sobaci, and Suat Karagul. "Toluene Related Toxic Optic Neuropathy." Neuro-Ophthalmology 33, no. 5 (2009): 248–52. http://dx.doi.org/10.1080/01658100902998757.

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12

Rucker, J. C., S. R. Hamilton, D. Bardenstein, C. M. Isada, and M. S. Lee. "Linezolid-associated toxic optic neuropathy." Neurology 66, no. 4 (2006): 595–98. http://dx.doi.org/10.1212/01.wnl.0000201313.24970.b8.

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13

Rucker, J. C., S. R. Hamilton, D. Bardenstein, C. M. Isada, and M. S. Lee. "Linezolid-associated toxic optic neuropathy." American Journal of Ophthalmology 142, no. 3 (2006): 534. http://dx.doi.org/10.1016/j.ajo.2006.07.006.

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14

Aljebreen, MeshaalA, AbdulazizK Alotaibi, and Malek Alrobaian. "Linezolid-Induced Toxic Optic Neuropathy." Middle East African Journal of Ophthalmology 27, no. 4 (2020): 235. http://dx.doi.org/10.4103/meajo.meajo_73_20.

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15

Sheremet, N. L., N. A. Khanakova, N. V. Zhorzholadze, and T. A. Nevinitsyna. "Clinical features of toxic optic neuropathies." Kazan medical journal 98, no. 3 (2017): 400–403. http://dx.doi.org/10.17750/kmj2017-400.

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Aim. To study the features of the clinical symptoms of toxic optic neuropathy. 
 Methods. 21 patients (42 eyes) with toxic optic neuropathy were examined with the use of standard ophthalmic exam, computer visual field test, spectral optical coherence tomography of the retina and optic nerve. 
 Results. Toxic optic neuropathies were caused by the acute (4 patients) or chronic (10 patients) alcohol intake, drug abuse (6 patients) and medications (ethambutol, 1 patient). In all patients bilateral visual deterioration with central scotomas with various levels of light sensitivity reducti
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16

Freund, Paul R., Tom Wright, and Edward A. Margolin. "Toxic Optic Neuropathy From Quinine Overdose." Journal of Neuro-Ophthalmology 40, no. 2 (2020): 258–61. http://dx.doi.org/10.1097/wno.0000000000000865.

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17

Savino, PeterJ, and HemaL Ramkumar. "Toxic optic neuropathy: An unusual cause." Indian Journal of Ophthalmology 62, no. 10 (2014): 1036. http://dx.doi.org/10.4103/0301-4738.146045.

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18

Merino, P., M. Luque, and E. Bouza. "Severe Toxic Optic Neuropathy and Isoniazid." Infectious Diseases in Clinical Practice 5, no. 4 (1996): 279–80. http://dx.doi.org/10.1097/00019048-199605000-00011.

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19

&NA;. "Severe Toxic Optic Neuropathy and Isoniazid." Infectious Diseases in Clinical Practice 5, no. 4 (1996): 281. http://dx.doi.org/10.1097/00019048-199605000-00012.

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20

Kervinen, Marko, Paula Widgren, Ville Saarela, Johanna Uusimaa, and Anne Remes. "Leber hereditary optic neuropathy mutations and toxic-genetic optic neuropathy - Authors' response." Acta Ophthalmologica 92, no. 1 (2013): e78-e79. http://dx.doi.org/10.1111/aos.12089.

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21

Santiesteban-Freixas, Rosaralis, Carlos E. Mendoza-Santiesteban, Yannara Columbie-Garbey, Alina Gonzalez Quevedo, Alberto Gonzalez Garcia, and Ramón Cabal Rodríguez. "Cuban Epidemic Optic Neuropathy and its Relationship to Toxic and Hereditary Optic Neuropathy." Seminars in Ophthalmology 25, no. 4 (2010): 112–22. http://dx.doi.org/10.3109/08820538.2010.500267.

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22

Ommurugan, Balaji, Dipanjan Bhattacharjee, and Navin Patil. "ISONIAZID THE CULPRIT BEHIND TOXIC OPTIC NEUROPATHY." Asian Journal of Pharmaceutical and Clinical Research 10, no. 7 (2017): 1. http://dx.doi.org/10.22159/ajpcr.2017.v10i7.17797.

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Literature regarding toxic optic neuropathy (TON) due to isoniazid (INH) is scarce. This diagnosis is often missed, leading to unnecessary delay in institution of corrective measures. Often, this delay can worsen the patient’s vision, with a high likelihood of development of serious damage to the patient’s vision. We report a case of a 49-year-old gentleman, afflicted with meningeal tuberculosis, who developed visual disturbances following the administration of antitubercular therapy. The patient’s vision improved dramatically following INH’s withdrawal. This case highlighted the need to keep
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23

Park, Su Jin, Jae Uk Jung, Yong Koo Kang, Bo Young Chun, and Byeong Jae Son. "Toxic Optic Neuropathy Caused by Chlorfenapyr Poisoning." Journal of the Korean Ophthalmological Society 59, no. 11 (2018): 1097. http://dx.doi.org/10.3341/jkos.2018.59.11.1097.

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24

Kogachi, Kaitlin, Anna Ter-Zakarian, Samuel Asanad, Alfredo Sadun, and Rustum Karanjia. "Toxic medications in Leber's hereditary optic neuropathy." Mitochondrion 46 (May 2019): 270–77. http://dx.doi.org/10.1016/j.mito.2018.07.007.

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25

Zoric, Lepsa, Aleksandra Ilic, Emina Colak, et al. "Tacrolimus-induced bilateral optic neuropathy: A case report." Vojnosanitetski pregled, no. 00 (2021): 4. http://dx.doi.org/10.2298/vsp201126004z.

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Intrduction. Tacrolimus (fujimycin or FK506) is a potent immunosuppressive drug with growing usage. It is usually used in prevention of transplanted organ rejection. Its use is highly valuable, but like other immunosupressants, it has adverse effects. One of them is optic neuropathy. Case report. A 47-year-old white male patients who had received tacrolimus therapy for nine years, after kidney transplantation, developed a subacute, painless vision loss on both eyes. He was thoroughly examined on different possible optic neuropathies and other causes of vision loss. After exclusion of other pos
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26

Wang, Li Lyung, Hee Jun Song, Young Hee Jung, and Ju-Yeun Lee. "Ischemic Optic Neuropathy Caused by Iron Deficiency Anemia Accompanied by Ethambutol-induced Toxic Optic Neuropathy." Journal of the Korean Ophthalmological Society 61, no. 11 (2020): 1399–405. http://dx.doi.org/10.3341/jkos.2020.61.11.1399.

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27

Bouffard, Marc A., Ruvandhi R. Nathavitharana, David S. Yassa, and Nurhan Torun. "Re-Treatment With Ethambutol After Toxic Optic Neuropathy." Journal of Neuro-Ophthalmology 37, no. 1 (2017): 40–42. http://dx.doi.org/10.1097/wno.0000000000000445.

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28

Mimouni, Michael, Liron Berkovitz, Irena Krasnitz, Itzchak Beiran, and EytanZ Blumenthal. "Isolated reversible toxic optic neuropathy secondary to linezolid." Journal of Clinical Ophthalmology and Research 5, no. 1 (2017): 40. http://dx.doi.org/10.4103/2320-3897.195309.

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29

Beaumont, W., P. Sustronck, and E. H. Souied. "A case of oxaliplatin-related toxic optic neuropathy." Journal Français d'Ophtalmologie 44, no. 7 (2021): e393-e395. http://dx.doi.org/10.1016/j.jfo.2020.10.013.

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30

Ioyleva, E. E., N. A. Gavrilova, A. V. Zinov’eva, and M. V. Kats. "Amiodarone-associated optic neuropathy in the treatment of cardiovascular diseases." Russian Ophthalmological Journal 13, no. 2 (2020): 83–87. http://dx.doi.org/10.21516/2072-0076-2020-13-2-83-87.

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An increase in the growth of cardiovascular diseases has been observed in the last few years. Cardiac rhythm disturbances, especially atrial fibrillation, in absence of cardioversion and proper prophylaxis lead to thromboembolic complications. Drug therapy in rhythm disorders consists of the many antiarrhythmic drugs, prescribed for a long period of time. This fact can result to the ocular toxicy, which have insidious and slow progression. First and foremost, there is a risk of amiodarone-associated toxicity. Amiodarone affects as anterior segment structures (photosensitivity, corneal and conj
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31

Ijaz, Umer, Asad Habib, Hassan Sajjad Rathore, and Muhammad Imran Sarwar. "SPECTRUM OF OPTIC NEUROPATHIES PRESENTING IN NEUROOPHTHALMOLOGY CLINIC AT AFIO." PAFMJ 71, no. 1 (2021): 112–16. http://dx.doi.org/10.51253/pafmj.v71i1.2435.

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Objective: To study the spectrum of optic neuropathies in patient’s presenting at AFIO Rawalpindi.
 Study Design: Descriptive study/retrospective study.
 Place and Duration of Study: Armed Forces Institute of Ophthalmology, Rawalpindi, from Jan 2017 to Dec 2017.
 Methodology: Retrospective analysis of hospital record of patients coming to neuro-ophthalmic clinic of ArmedForces Institute of Ophthalmology (AFIO), Rawalpindi, from Jan to Dec 2017 was done. Only patients with clearfinal diagnosis of neurophthalmic disease were included. Those with vague diagnosis were excluded. Data
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32

Fortenberry, Sandra, Lloyd Pate, and Pat Segu. "Poster 40: Optic Neuropathy Secondary to Nutritional/Toxic Amblyopia." Optometry - Journal of the American Optometric Association 79, no. 6 (2008): 317. http://dx.doi.org/10.1016/j.optm.2008.04.047.

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33

Yang, H. K., M. J. Park, J.-H. Lee, C.-T. Lee, J. S. Park, and J.-M. Hwang. "Incidence of toxic optic neuropathy with low-dose ethambutol." International Journal of Tuberculosis and Lung Disease 20, no. 2 (2016): 261–64. http://dx.doi.org/10.5588/ijtld.15.0275.

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34

LUCAS, RS, and BP LEROY. "Toxic optic neuropathy secondary to disulfiram: a case series." Acta Ophthalmologica 89, s248 (2011): 0. http://dx.doi.org/10.1111/j.1755-3768.2011.2265.x.

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35

Rana, Proteesh, Vandana Roy, and Jamshed Ahmad. "Drug-induced optic neuropathy in a case of extensively drug-resistant pulmonary tuberculosis." Journal of Basic and Clinical Physiology and Pharmacology 30, no. 1 (2018): 139–40. http://dx.doi.org/10.1515/jbcpp-2018-0007.

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Abstract We report a 26-year-old male patient diagnosed with extensively drug-resistant pulmonary tuberculosis presenting with reversible bilateral toxic optic neuropathy induced by the use of linezolid along with high-dose isoniazid. The case emphasizes the importance of recognizing toxic optic neuritis in patients on antitubercular therapy. Prompt recognition and treatment of such adverse drug reactions will reduce the associated morbidity.
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36

Venkatramani, Devendra V., Shubhra Goel, Vineet Ratra, and Rashmin Anilkumar Gandhi. "Toxic optic neuropathy following ingestion of homeopathic medication Arnica-30." Cutaneous and Ocular Toxicology 32, no. 1 (2012): 95–97. http://dx.doi.org/10.3109/15569527.2012.708910.

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37

Tanrivermis Sayit, Asli, Kerim Aslan, Muzaffer Elmali, and Inci Gungor. "Methanol-induced toxic optic neuropathy with diffusion weighted MRI findings." Cutaneous and Ocular Toxicology 35, no. 4 (2016): 337–40. http://dx.doi.org/10.3109/15569527.2015.1122031.

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38

Radhakrishnan, D., N. Kumar, S. Ramanuj, R. Shree, M. Rajat, and S. Kumari. "Toxic optic neuropathy- An uncommon complication of commonly used antibiotics." Journal of the Neurological Sciences 405 (October 2019): 262. http://dx.doi.org/10.1016/j.jns.2019.10.1300.

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39

Gokoffski, Kimberly K., and Vivek R. Patel. "A case of reversible toxic optic neuropathy from tacrolimus (FK506)." American Journal of Ophthalmology Case Reports 20 (December 2020): 100932. http://dx.doi.org/10.1016/j.ajoc.2020.100932.

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40

Monferrer-Adsuara, Clara, Carolina García-Villanueva, Lucía Mata-Moret, Miguel Ortiz-Salvador, Lidia Remolí-Sargues, and Enrique Cervera-Taulet. "Case Report: Nutritional and Toxic Optic Neuropathy: A Diagnostic Dilemma." Optometry and Vision Science 97, no. 7 (2020): 477–81. http://dx.doi.org/10.1097/opx.0000000000001531.

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41

Lee, E., S. Burger, C. Melton, M. Mullen, F. Warren, and R. Press. "Linezolid-Associated Toxic Optic Neuropathy: A Report of 2 Cases." Clinical Infectious Diseases 37, no. 10 (2003): 1389–91. http://dx.doi.org/10.1086/379012.

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42

Naidu Sugnanam, Kirthi Kumar, Natalie H. Turner, and Stephen O'Hagan. "Docetaxel-Related Toxic Optic Neuropathy in Management of Prostate Adenocarcinoma." Clinical Genitourinary Cancer 15, no. 1 (2017): e115-e118. http://dx.doi.org/10.1016/j.clgc.2016.07.004.

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43

Okonkwo, Arthur. "Toxic Optic Neuropathy secondary to Systemic Chloramphenicol for Septic Arthritis: Case Report." Journal of Pharmaceutics and Therapeutics 4, no. 1 (2018): 152–55. http://dx.doi.org/10.18314/jpt.v4i1.1153.

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Introduction – Chloramphenicol is a broad-spectrum antibiotic with excellent tissue penetration. Systemic use was popularised in the 1950s due to its affordability andease of preparation. It is now rarely used in developed countries due to its significant side effect profile including toxic optic neuropathy.
 Case Description – A 68-year-old female presented to a neighbouring eye department with a 2-month history of bilateral visual deterioration, initially thought to be due to cataracts. However, due to the moderate cataract density and visual acuities of 6/60 and hand movements a medica
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44

Kuzenko, Olena, Yuri Demin, and Yevhen Kuzenko. "RESEARCH OF REPARATIVE MECHANISMS IN THE OPTIC NERVE IN TOXIC NEUROPATHY CAUSED BY Cr (VI)." ScienceRise, no. 6 (December 30, 2020): 31–39. http://dx.doi.org/10.21303/2313-8416.2020.001549.

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Intoxication lesions of the optic nerve (toxic optic neuropathy, TON) most often occur under the influence of exogenous factors, including heavy metals. Сell survival under stress have involves heat shock proteins (HSPs). The aim of the research. To assess the optic nerve’s immunoreactivity to heat shock proteins of the HSP70 and HSP90α families and reveal its relationship with the severity of morphological changes in toxic optic neuropathy caused by Cr (VI). Materials and methods. The study was conducted on 48 mature male rats. The experimental groups were given to drink water with Cr(VI) for
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45

Moodley, Anand, Sudika Bhola, Fierdoz Omar, and Jade Mogambery. "Antiretroviral therapy-induced Leber’s hereditary optic neuropathy." Southern African Journal of HIV Medicine 15, no. 2 (2014): 69–71. http://dx.doi.org/10.4102/sajhivmed.v15i2.24.

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Optic neuropathy in HIV-infected patients results from the HIV infection itself, post-infectious auto-immune disease, opportunistic infections and drugs. Nucleoside reverse transcriptase inhibitors (NRTIs) such as zidovudine and stavudine have known mitochondrial toxicity and can cause mitochondrial myopathies, neuropathies, hyperlactataemia, and can induce mitochondrial genetic disorders. Individuals with the mutation for Leber’s hereditary optic neuropathy (LHON), a mitochondrial disorder, are usually asymptomatic but develop visual loss when exposed to external triggers such as smoking. We
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46

Alroughani, R., and R. Behbehani. "Optic Nerve Sheath Meningioma Masquerading as Optic Neuritis." Case Reports in Neurological Medicine 2016 (2016): 1–3. http://dx.doi.org/10.1155/2016/5419432.

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Optic neuritis is a common presentation of demyelinating disorders such as multiple sclerosis. It typically presents with acute painful monocular vision loss, whereas chronic optic neuropathy can be caused by compressive lesions along the anterior visual pathway, genetic, toxic, or nutritional causes. We report an unusual presentation mimicking optic neuritis, which was subsequently diagnosed as optic nerve sheath meningioma (ONSM). Misinterpretation of white matter lesions on MRI of brain and the failure to image the optic nerves at the time of acute loss of vision led to the misdiagnosis of
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47

Ino-Ue, Masanori, and Misao Yamamoto. "Toxic Optic Neuropathy: Psychotropics and Ethambutol Inhibit Myelin Basic Protein Phosphorylation." Journal of Toxicology: Cutaneous and Ocular Toxicology 18, no. 1 (1999): 13–22. http://dx.doi.org/10.3109/15569529909049320.

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48

Sanaei-Zadeh, H. "How should the ophthalmologists treat the methanol-induced toxic optic neuropathy?" Nepalese Journal of Ophthalmology 4, no. 2 (2012): 348–50. http://dx.doi.org/10.3126/nepjoph.v4i2.6563.

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49

Pakravan, Mohammad, Hamed Esfandiari, Nasrin Sanjari, and Elham Ghahari. "Erythropoietin as an adjunctive treatment for methanol-induced toxic optic neuropathy." American Journal of Drug and Alcohol Abuse 42, no. 6 (2016): 633–39. http://dx.doi.org/10.1080/00952990.2016.1198800.

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50

Shah, Ritish K. "Clinical and Etiological Profile of Patients with Optic Disc Edema in Tertiary Care Centre of Nepal." Journal of Institute of Medicine Nepal 41, no. 1 (2019): 24–30. http://dx.doi.org/10.3126/jiom.v41i1.28588.

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Introduction: Optic disc edema can be a manifestation of various neurological disorders. Identification of those causes is possible in most cases using tests like visual acuity, color vision, visual field and suitable radiological imaging. Study in Nepalese population with regard to optic disc edema is scarce. Hence this study aims to act as a guideline for evaluation of such cases and help in further studies in this regard.
 Methods: A descriptive, cross-sectional study was conducted in all cases of optic disc edema presenting to neuro-ophthalmology clinic of B.P. Koirala Lions Centre fo
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