Academic literature on the topic 'Toxicita substrátu'

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Journal articles on the topic "Toxicita substrátu"

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Silverio, Juliana Milene, Cleberton Correia Santos, Rodrigo da Silva Bernardes, Giselly Marques Espíndola, Hércules Lazari Meurer, and Maria do Carmo Vieira. "GERMINAÇÃO DE SEMENTES E VIGOR DE PLÂNTULAS DE Arctium lappa L. SUBMETIDAS À TOXICIDADE DE ALUMÍNIO." Revista Brasileira de Engenharia de Biossistemas 15, no. 1 (2021): 154–67. http://dx.doi.org/10.18011/bioeng2021v15n1p154-167.

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O alumínio (Al) presente nos solos ácidos reduz o potencial fisiológico de sementes e limita o crescimento plântulas de diversas espécies de interesse agronômico. Entretanto, informações quanto à toxicidade do Al em Arctium lappa L. (bardana, Asteraceae) são escassos. Objetivou-se nesse estudo avaliar o efeito do estresse por alumínio na germinação e no vigor de plântulas de A. lappa. Foram testadas cinco concentrações de sulfato de alumínio hidratado Al2(SO4)3·16H2O: 0 (controle), 5, 10, 15 e 20 mmol L-1. O teste de germinação foi feito em caixas do tipo Gerbox (sobre papel – SP) e em rolo pa
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Garcia, Kaio Gráculo Vieira, Vânia Felipe Freire Gomes, Aldênia Mendes Mascena de Almeida, and Paulo Furtado Mendes Filho. "Micorrizas arbusculares no crescimento de mudas de sabiá em um substrato proveniente da mineração de manganês." Revista Verde de Agroecologia e Desenvolvimento Sustentável 11, no. 2 (2016): 15. http://dx.doi.org/10.18378/rvads.v11i2.4088.

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<p>O manganês (Mn) é considerado um micronutriente essencial às plantas, porém o seu excesso pode resultar em toxidez, causando clorose e necrose nas folhas. O uso de leguminosas inoculadas com fungos micorrízicos arbusculares tem se tornado uma importante estratégia do ponto de vista da remediação de áreas contaminadas com metais como é o caso do manganês. Neste sentido, o objetivo deste trabalho foi avaliar o crescimento de mudas de <em>Mimosa caesalpiniaefolia</em> Benth. inoculadas com micorrizas arbusculares sob condições de substrato esterilizado e natural proveniente d
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Torres Lozada, Patricia, Yazmín Stefhany Carabalí Rivera, and Luz Edith Barba Ho. "Determination of leachate toxicity through acute toxicity using Daphnia pulex and Anaerobic Toxicity Assays." Ingeniería e Investigación 37, no. 1 (2017): 16. http://dx.doi.org/10.15446/ing.investig.v37n1.54220.

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The municipal solid waste (MSW) of large cities, in particular in developing countries, is mainly disposed of in landfills (LFs), whose inadequate management generates the emission of greenhouse gases and the production of leachates with high concentrations of organic and inorganic matter and occasionally heavy metals. In this study, the toxicity of the leachates from an intermediate-age municipal landfill was evaluated by ecotoxicity and anaerobic digestion tests. The acute toxicity assays with Daphnia pulex presented a toxic unit (TU) value of 49.5%, which indicates that these leachates shou
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Speece, R. E., G. F. Parkin, and S. K. Bhattacharya. "Modelling Toxic Response of Anaerobic Treatment." Water Science and Technology 18, no. 12 (1986): 27–39. http://dx.doi.org/10.2166/wst.1986.0161.

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The toxicity response of the anaerobic treatment process can be modelled from a number of different approaches. Toxicity affects the growth rate and the effluent substrate concentration and can be modelled by competitive and uncompetitive inhibition. The biological safety factor is reduced. Most toxicants exhibit reversible toxicity, which is quite significant. Acclimation is noted to some toxicants. Molecular structure can be used to model and predict toxicity.
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Barthet, Gael, Anastasios Georgakopoulos та Nikolaos K. Robakis. "Cellular mechanisms of γ-secretase substrate selection, processing and toxicity". Progress in Neurobiology 98, № 2 (2012): 166–75. http://dx.doi.org/10.1016/j.pneurobio.2012.05.006.

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Jung, Keumhee, Gabriel Bitton, and Ben Koopman. "Selective assay for heavy metal toxicity using a fluorogenic substrate." Environmental Toxicology and Chemistry 15, no. 5 (1996): 711–14. http://dx.doi.org/10.1002/etc.5620150515.

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He, Jingting, Junfeng Zhai, Dengbin Yu, et al. "A respiration substrate-less isolation method for acute toxicity assessment." Chemosphere 244 (April 2020): 125511. http://dx.doi.org/10.1016/j.chemosphere.2019.125511.

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Bardaweel, Sanaa K., Rana Abu-Dahab, and Nour F. Almomani. "An in vitro based investigation into the cytotoxic effects of D-amino acids." Acta Pharmaceutica 63, no. 4 (2013): 467–78. http://dx.doi.org/10.2478/acph-2013-0032.

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Abstract In the present study, cytotoxic effects of D-Ala, D-Pro and D-Lys are demonstrated. In an effort to study the possible mechanisms of the observed cytotoxicity, catalase activity, H2O2 generation, and apoptotic activity were measured in HeLa and MCF-7 cell lines. Although D-Lys is a poor substrate for DAO and therefore low H2O2 was detected, it was shown to provoke severe impairment of cellular integrity and survival. Interestingly, a very good substrate for DAO, such as D-Pro, did not substantially reduce cell viability. On the other hand, a moderate substrate for DAO, represented by
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Paul, John H., and Wade H. Jeffrey. "The effect of surfactants on the attachment of estuarine and marine bacteria to surfaces." Canadian Journal of Microbiology 31, no. 3 (1985): 224–28. http://dx.doi.org/10.1139/m85-043.

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The effect of dilute surfactants on bacterial attachment to hydrophilic and hydrophobic substrata has been investigated. Triton X-100 at 0.002% completely inhibited attachment to polystyrene, a hydrophobic surface, for 10 of 11 isolates and all isolates at 0.01%. This concentration of surfactant also caused displacement of previously attached Vibrio proteolytica cells. Attachment to glass, a hydrophilic substratum, was far less sensitive to surfactants, and one isolate showed no inhibition at 0.1%, the highest concentration employed. Concentrations of surfactant sufficient to completely inhibi
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Mann, R. A. "Phosphorus adsorption and desorption characteristics of constructed wetland gravels and steelworks by-products." Soil Research 35, no. 2 (1997): 375. http://dx.doi.org/10.1071/s96041.

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Laboratory phosphorus (P) adsorption and desorption experiments were conducted on 9 substrata to evaluate their potential to remove P from sewage effluent. The substrata comprised 2 gravels used in constructed wetlands, Hawkesbury sandstone, and 6 steelworks by-products: granulated blast furnace slag, blast furnace slag, steel slag, fly ash, bottom ash, and coal wash. The studies involved ion-exchange experiments and calculation of Langmuir and Freundlich adsorption isotherms and column adsorption/desorption trials. The ability to adsorb P was then correlated to the physico-chemical attributes
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Dissertations / Theses on the topic "Toxicita substrátu"

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Lebeau, Thierry. "Fermentation alcoolique de mélanges glucose-xylose par les levures Candida shehatae et Saccharomyces cerevisiae co-immobilisées dans un nouveau type de bioréacteur à membrane." Rouen, 1997. http://www.theses.fr/1997ROUES014.

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Ce travail étudie la fermentation alcoolique d'un mélange de glucose (35 g/l) et de xylose (15 g/l) par Candida shehatae et Saccharomyces cerevisiae co-immobilisées dans une structure membranaire composite constituée d'une couche plane d'agar enserree entre deux membranes microporeuses. L'utilisation d'un bioréacteur à double chambre a permis une alimentation dissymétrique en substrats et en dioxygène de la structure immobilisatrice et de répondre ainsi aux exigences de culture de chacune des deux espèces. Lors de fermentations discontinues, nous avons montré que les levures consommaient total
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Carredano, Enrique. "Crystallographic studies of phospholipase A2 and naphtalene 1,2-dioxygenase : implications for phospholipase toxicity and dioxygenase substrate specificity /." Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 1999. http://epsilon.slu.se/avh/1999/91-576-5700-9.pdf.

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Aguedo, Mario. "Biotransformation de lipides en arômes par Yarrowia lipolytica : interactions avec le substrat, excrétion et toxicité des métabolites produits." Dijon, 2002. http://www.theses.fr/2002DIJOS072.

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Yarrowia lipolytica produit, par biotransformation, de la g-décalactone, composé d'arôme issu de la dégradation peroxysomale du ricinoléate de méthyle. Certaines étapes potentiellement limitantes ont été étudiées. L'assimilation du substrat émulsionné se fait par adhésion de microgouttelettes sur la surface cellulaire (via des interactions hydrophobes et de type acide/base de Lewis) et par action d'un surfactant. Le substrat n'est pas accumulé, ce qui rend non limitant sa dégradation intracellulaire en acide 4-hydroxy-décanoi͏̈que, précurseur direct de la g-décalactone. Ces deux composés peuve
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Scherrer, Pierre. "La regeneration de la mangrove apres un deversement accidentel d'hydrocarbures : phytotoxicite et evolution physico-chimique du petrole brut piege dans le substrat." Toulouse 3, 1988. http://www.theses.fr/1988TOU30136.

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Ce travail traite de la recolonisation, par les especes vegetales de la mangrove, d'un sol pollue par les hydrocarbures. La premiere partie concerne les experimentations de terrain. Des parcelles sont polluees avec du petrole brut associe, selon les cas, a un dispersant ou un activateur de la biodegradation. Des plantations de fruits ou de plantules sont realisees par la suite. En guadeloupe, les especes etudiees sont rhizophora mangle et avicennia germinans. A borneo, il s'agit d'especes des genres sonneratia et avicennia. La deuxieme partie est relative aux experiences realisees en chambre t
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Liotta, Flavia. "Bio-methanation tests and mathematical modelling to assess the role of moisture content on anaerobic digestion of organic waste." Phd thesis, Université Paris-Est, 2013. http://tel.archives-ouvertes.fr/tel-00967951.

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Dry Anaerobic Digestion (AD) presents different advantages if compared to wet AD, i.e. smaller reactor size, lesser water addition, digestate production and pretreatment needed, although several studies have demonstrated that water promotes substrate hydrolysis and enables the transfer of process intermediates and nutrients to bacterial sites. To better understand the role of water on AD, dry and semidry digestion tests of selected complex organic substrates (food waste, rice straw, carrot waste), with various TS contents of the treated biomass have been carried out in the present study. The r
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Clift, Martin James David. "Quantum dots : an investigation into how differing surface characteristics affect their interaction with macrophages in vitro." Thesis, Edinburgh Napier University, 2009. http://researchrepository.napier.ac.uk/Output/2557.

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Quantum dots (QDs) are potentially advantageous tools for both diagnostics and therapeutics due to their light emitting characteristics. The impact of QDs on biological systems however, is not fully understood. The aim of this project therefore, was to investigate the interaction of a series of different surface modifies QDs with macrophages and their subsequent toxicity. CdTe/CdSe (core), ZnS (shell) QDs with either an organic, COOH or NH2 polyethylene glycol (PEG) surface coatings were used. Fluorescent COOH polystyrene beads (PBs) at (Ø) 20nm and 200nm were also studied. J774.A1 murine ‘mac
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BIZOS, Jiří. "Reakce půdních vířníků (Rotifera) na chemický stres v substrátech hnědouhelné výsypky." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-55101.

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Abundance and species composition of soil rotifer communities was investigated in two seasons and six sites on dumps in the Sokolov mining area (Czech Republic). Every site was split into three plots, which differed in toxicity for vegetation and chemical composition of spoil material. The ability of soil rotifers to live in environment of spoil materials and the effect of pollution were studied in field conditions. According to results, abundance and species composition did not correspond to chemical environmental characteristics. Species composition of rotifer communities was affected by env
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Venclovská, Lenka. "Toxicita výsypkových substrátů a možnosti jejího zmírnění." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-298567.

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The content of this diploma thesis is to verify of possibilities for remediation spoil heap toxicity in Sokolov area, by the help of creating biological crusts. The main question of this work is the possibility of using algae to create biological crust on toxical substrates, which could improve the properties of substrates and contribute to the acceleration of succession. The correctness of this theory was tested using two tests on toxic soils in spoil heaps near Sokolov. In the first test (laboratory test) have been chosen two of the soils and the higher plants, in most cases, even did not ge
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Zadinová, Radka. "Vliv toxicity a ostatních vlastností výsypkových substrátů na růst rostlin." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-321041.

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Surface mining of coal in the country leaves a lot of damage. This type of mining is characterized by the creation of large external dumps. The dumps often contain substrates with toxic substances or substances which become toxic after reaction with air. These substrates are toxic to plants and edaphon. This work is intended to show what properties of substrates are important for phytotoxicity. The location of research was selected including 3 different kinds of substrates, terrain unevenness and a lagoon in the middle. Coordinate grid has been created on the selected location. At each point a
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Ely, Roger L. "Effects of substrate interactions, toxicity, and bacterial response during cometabolism of chlorinted solvents by nitrifying bacteria." Thesis, 1996. http://hdl.handle.net/1957/34644.

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Books on the topic "Toxicita substrátu"

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Ely, Roger L. Effects of substrate interactions, toxicity, and bacterial response during cometabolism of chlorinted solvents by nitrifying bacteria. 1996.

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Book chapters on the topic "Toxicita substrátu"

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Walsh, Christopher. "Fluorinated Substrate Analogs: Routes of Metabolism and Selective Toxicity." In Advances in Enzymology - and Related Areas of Molecular Biology. John Wiley & Sons, Inc., 2006. http://dx.doi.org/10.1002/9780470123010.ch3.

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Pinel, Dominic, and Vincent J. J. Martin. "Meiotic Recombination-Based Genome Shuffling ofSaccharomyces CerevisiaeandSchefferomyces Stiptisfor Increased Inhibitor Tolerance to Lignocellulosic Substrate Toxicity." In Engineering Complex Phenotypes in Industrial Strains. John Wiley & Sons, Inc., 2012. http://dx.doi.org/10.1002/9781118433034.ch9.

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William Tong, C. Y. "Antivirals." In Tutorial Topics in Infection for the Combined Infection Training Programme. Oxford University Press, 2019. http://dx.doi.org/10.1093/oso/9780198801740.003.0059.

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Viruses are obligate intracellular pathogens that utilize many of the host metabolic machineries for reproduction. Unlike the binary fission of bacteria, the replication process of viruses is more like a production line with a final assembly process to produce their progenies. Any agents used to prevent viral replication must be specific to the virus and cause as little problem for the host as possible. The rate of virus replication can also cause problems. In rapidly reproducing viruses, the high replication rate generates mutants that could be selected for resistance to antivirals. On the other hand, viruses could remain latent with little metabolic activity. None of the current antivirals are effective against latent viruses. The life cycle of a typical virus goes through the following stages: ● Attachment; ● Entry and uncoating; ● Replication of viral nucleic acid; ● Establishing latency or persistent infection (in some viruses); ● Translation of viral protein and post-translational modifications; ● Secretion and assembly of viral particles; and ● Release from host cells. Each of these steps can be used as antiviral targets. The most common strategy is to use a nucleoside analogue as a false substrate. However, such a false substrate can also be taken up by host polymerase and could result in toxicity, e.g. mitochondrial toxicity in some of the earlier antiretroviral drugs. The most successful example to circumvent this problem is aciclovir, which is the prodrug of the active agent aciclovir tri-phosphate. Aciclovir is a substrate for the viral enzyme thymidine kinase carried by the herpes simplex virus (HSV) and varicella-zoster virus (VZV), which converts it into aciclovir monophosphate. As this only happens inside cells infected by HSV or VZV, it is concentrated only in infected cells. Host enzymes then add further phosphates to form the active agent aciclovir triphosphate, which has a higher affinity to viral polymerase than host polymerase. It acts as a false substrate for the viral polymerase and results in premature termination of nucleic acid replication. A similar mechanism is utilized in ganciclovir against cytomegalovirus (CMV). The viral phosphate kinase involved in the case of CMV is the UL97 protein.
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Das, Rajib, Vibhav Ambardekar, and Partha Pratim Bandyopadhyay. "Titanium Dioxide and Its Applications in Mechanical, Electrical, Optical, and Biomedical Fields." In Titanium Dioxide [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98805.

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Titanium dioxide (TiO2), owing to its non-toxicity, chemical stability, and low cost, is one of the most valuable ceramic materials. TiO2 derived coatings not only act like a ceramic protective shield for the metallic substrate but also provide cathodic protection to the metals against the corrosive solution under Ultraviolet (UV) illumination. Being biocompatible, TiO2 coatings are widely used as an implant material. The acid treatment of TiO2 promotes the attachment of cells and bone tissue integration with the implant. In this chapter, the applications of TiO2 as a corrosion inhibitor and bioactive material are briefly discussed. The semiconducting nature and high refractive index of TiO2 conferred UV shielding properties, allowing it to absorb or reflect UV rays. Several studies showed that a high ultraviolet protection factor (UPF) was achieved by incorporating TiO2 in the sunscreens (to protect the human skin) and textile fibers (to minimize its photochemical degradation). The rutile phase of TiO2 offers high whiteness, and opacity owing to its tendency to scatter light. These properties enable TiO2 to be used as a pigment a brief review of which is also addressed in this chapter. Since TiO2 exhibits high hardness and fracture toughness, the wear rate of composite is considerably reduced by adding TiO2. On interacting with gases like hydrogen at elevated temperatures, the electrical resistance of TiO2 changes to some different value. The change in resistance can be utilized in detecting various gases that enables TiO2 to be used as a gas sensor for monitoring different gases. This chapter attempts to provide a comprehensive review of applications of TiO2 as an anti-corrosion, wear-resistant material in the mechanical field, a UV absorber, pigment in the optical sector, a bioactive material in the biomedical field, and a gas sensor in the electrical domain.
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Taber, Douglass. "The Castle Synthesis of (-)-Acutumine." In Organic Synthesis. Oxford University Press, 2011. http://dx.doi.org/10.1093/oso/9780199764549.003.0104.

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The complex tetracyclic alkaloid (-)-acutumine 3, isolated from the Asian vine Menispermum dauricum, shows selective T-cell toxicity. The two adjacent cyclic all-carbon quaternary centers of 3 offered a particular challenge. Steven L. Castle of Brigham Young University solved (J. Am. Chem. Soc. 2009, 131, 6674) this problem by effecting net enantioselective conjugate allylation of the enantiomerically pure substrate 1 to give 2 with high diastereocontrol. The starting coupling partners ( Organic Lett . 2006, 8, 3757; Organic Lett. 2007, 9, 4033) for the synthesis were the Weinreb amide 4, prepared over several steps from 2,3- dimethoxyphenol, and the diastereomerically- and enantiomerically-pure cyclopentenyl iodide 5, prepared by singlet oxygenation of cyclopentadiene followed by enzymatic hydrolysis. Transmetalation of 5 by the Knochel protocol, addition of the resulting organometallic to 4 and enantioselective (and therefore diastereoselective) reduction of the resulting ketone delivered the alcohol 6. Methods for installing cyclic halogenated stereogenic centers are not well developed. Exposure of the allylic alcohol to mesyl chloride gave the chloride 7 with inversion of absolute configuration. Remarkably, this chlorinated center was carried through the rest of the synthesis without being disturbed. A central step in the synthesis of 3 was the spirocyclization of 7 to 8. Initially, iodine atom abstraction generated the aryl radical. The diastereoselectivity of the radical addition to the cyclopentene was set by the adjacent silyloxy group. The α-keto radical so generated reacted with the Et3Al to give a species that was oxidized by the oxaziridine to the α-keto alcohol, again with remarkable diastereocontrol. Conjugate addition to the cyclohexenone 1 failed, so an alternative strategy was developed, diastereoselective 1,2-allylation of the ketone followed by oxy-Cope rearrangement. The stereogenic centers of 1 are remote from the cyclohexenone carbonyl, so could not be used to control the facial selectivity of the addition. Fortunately, the stoichiometric enantiomerically-pure Nakamura reagent delivered the allyl group preferentially to one face of the ketone 1, to give 9. The subsequent sigmatropic rearrangement to establish the very congested second quaternary center of 2 then proceeded with remarkable facility, at 0°C for one hour.
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Conference papers on the topic "Toxicita substrátu"

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Liu, Fei, Anis N. Nordin, Fang Li, and Ioana Voiculescu. "A Sensitive Multiparametric Biosensor With Capabilities of Rapid Toxicity Detection of Drinking Water." In ASME 2013 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/imece2013-62281.

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Recently, there has been interest to develop biosensors based on live mammalian cells to monitor the toxicity of water. The cell viability after exposure to toxic water can be monitored by electric cell-substrate impedance sensing (ECIS) of the cell membrane. However, these impedance based toxicity sensors can only provide one single sensing endpoint (impedance measurement), and many toxicants cannot be detected at the concentration between Military Exposure Guideline levels and estimated Human Lethal Concentrations. The goal of this paper is to provide a rapid and sensitive sensing platform f
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Liu, Fei, Tingting Chen, Xudong Zhang, Fang Li, and Ioana Voiculescu. "Study of Long Term Viability of Endothelial Cells on Biochip for Rapid and Reliable Water Toxicity Measurements." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93035.

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Measuring water toxicity is a lengthy process, and rapid analytical methods are limited. A complementary approach is to measure water toxicity on live cells via electric cell-substrate impedance sensing (ECIS) using a field portable device. This paper presents a study of the longevity of bovine aortic endothelial cell (BAECs VEC Technologies, Rensselaer, NY) by integrating a microfluidic device onto the ECIS sensors. This microfluidic chamber with a network of tree-like perfusion microfluidic channels for cell media delivery to the culturing chamber was fabricated from a biocompatible polymer
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Lee, Kun-Lin, Fang Li, Anis Nurashikin Nordin, and Ioana Voiculescu. "Preliminary Exploration of Cell-Based SAW Detection for Water Toxicity." In ASME 2018 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2018. http://dx.doi.org/10.1115/imece2018-86436.

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Nowadays, many surface sensing mechanisms exist, not all of them can be applied in water-based environment. Most of surface sensing techniques were developed in air-based environment. In order to obtain a potential cell-based biosensor, the sensing method needs to be reliable and repeatable in liquid environment. Therefore, we adapt existing air-based surface acoustic sensor and promote the technology into water-based applications. The goal of this study is to apply surface acoustic waves (SAW) for water-based environment sensing. We will use shear horizontal wave (SH wave) as surface sensing
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Liu, Fei, Fang Li, Ali Khademhosseini, and Ioana Voiculescu. "Multiparametric MEMS Biosensors With Integrated Impedance Spectroscopy and Gravimetric Measurements for Water Toxicity Sensing." In ASME 2013 2nd Global Congress on NanoEngineering for Medicine and Biology. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/nemb2013-93034.

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This paper presents the design, fabrication and characterization of a novel multiparametric microelectromechanical (MEMS) biosensor based on live mammalian cells with capabilities of sensing the toxicity of field water with minimized false-positive rate. This biosensor combines two biosensing techniques, resonant frequency measurements and electric cell-substrate impedance sensing (ECIS) on a single chip. The sensor is based on the innovative placement of the working microelectrode for ECIS technique as the upper electrode of a quartz crystal microbalance (QCM) resonator. This multiparametric
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Choi, Chang K., Chuck Margraves, Anthony E. English, and Kenneth D. Kihm. "Opto-Electric Biosensor to Examine In Vitro Toxicity Stimuli to Endothelial Cell Motility and Morphology." In ASME 2007 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2007. http://dx.doi.org/10.1115/sbc2007-176715.

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An integrated opto-electric biosensor is developed that uses an optically transparent and electrically conductive indium tin oxide (ITO) thin film coated on a slide glass substrate. This biosensor can simultaneously acquire the micro-impedance response and microscopic images of live cells in vitro under various toxic agent stimuli. The dynamic response of live porcine pulmonary artery endothelial cells (PPAECs) exposed to various doses of cytochalasin D are comprehensively examined by monitoring the micro-impedance characteristics at a specified frequency and DICM images using the opto-electri
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Copeland, D. Scott, M. Kaysar Rahim, Jeffrey C. Suhling, et al. "High Reliability Flip Chip Using Low CTE Laminate Substrates." In ASME 2005 International Mechanical Engineering Congress and Exposition. ASMEDC, 2005. http://dx.doi.org/10.1115/imece2005-82662.

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In this work, we report on our efforts to develop high reliability flip chip on laminate assemblies for deployment in harsh thermal cycling environments characteristic of ground and aerospace vehicles (e.g. −55 to 150 °C). Reliability enhancement has been achieved through the use of a novel low expansion, high stiffness, and relatively low cost laminate substrate material that virtually eliminates CTE mismatches between the silicon die and top layer PCB interconnect. The utilized laminate features a sandwich construction that contains standard FR-406 outer layers surrounding a low expansion hi
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"Molecular composition - inhibition activity relationships for humic substances narrow fractions sets obtained by solid-phase extraction." In Sixth International Conference on Humic Innovative Technologies "Humic Substances and Eco-Adaptive Technologies ”(HIT – 2021). Non-Commercial Partnership "Center for Biogenic Resources "Humus Sapiens" (NP CBR "Humus Sapiens"), 2021. http://dx.doi.org/10.36291/hit.2021.mikhnevich.001.

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Humic substances (HS) have a wide spectrum of biological activity including inhibitory activity against β-lactamases.1 The latter are capable of hydrolyzing beta-lactam antibiotics and represent one of the main pathways of bacterial antibiotic resistance. HS are characterized by low toxicity and good solubility in water. A use of HS for therapeutic purposes is hindered by extreme molecular heterogeneity and high level of isomeric complexity. Solid-phase extraction (SPE) fractionation in combination with ultra-high resolution mass spectrometry (FTICR MS) is a promising method to simplify this m
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