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Journal articles on the topic 'Toxicita substrátu'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Silverio, Juliana Milene, Cleberton Correia Santos, Rodrigo da Silva Bernardes, Giselly Marques Espíndola, Hércules Lazari Meurer, and Maria do Carmo Vieira. "GERMINAÇÃO DE SEMENTES E VIGOR DE PLÂNTULAS DE Arctium lappa L. SUBMETIDAS À TOXICIDADE DE ALUMÍNIO." Revista Brasileira de Engenharia de Biossistemas 15, no. 1 (2021): 154–67. http://dx.doi.org/10.18011/bioeng2021v15n1p154-167.

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O alumínio (Al) presente nos solos ácidos reduz o potencial fisiológico de sementes e limita o crescimento plântulas de diversas espécies de interesse agronômico. Entretanto, informações quanto à toxicidade do Al em Arctium lappa L. (bardana, Asteraceae) são escassos. Objetivou-se nesse estudo avaliar o efeito do estresse por alumínio na germinação e no vigor de plântulas de A. lappa. Foram testadas cinco concentrações de sulfato de alumínio hidratado Al2(SO4)3·16H2O: 0 (controle), 5, 10, 15 e 20 mmol L-1. O teste de germinação foi feito em caixas do tipo Gerbox (sobre papel – SP) e em rolo pa

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Garcia, Kaio Gráculo Vieira, Vânia Felipe Freire Gomes, Aldênia Mendes Mascena de Almeida, and Paulo Furtado Mendes Filho. "Micorrizas arbusculares no crescimento de mudas de sabiá em um substrato proveniente da mineração de manganês." Revista Verde de Agroecologia e Desenvolvimento Sustentável 11, no. 2 (2016): 15. http://dx.doi.org/10.18378/rvads.v11i2.4088.

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<p>O manganês (Mn) é considerado um micronutriente essencial às plantas, porém o seu excesso pode resultar em toxidez, causando clorose e necrose nas folhas. O uso de leguminosas inoculadas com fungos micorrízicos arbusculares tem se tornado uma importante estratégia do ponto de vista da remediação de áreas contaminadas com metais como é o caso do manganês. Neste sentido, o objetivo deste trabalho foi avaliar o crescimento de mudas de <em>Mimosa caesalpiniaefolia</em> Benth. inoculadas com micorrizas arbusculares sob condições de substrato esterilizado e natural proveniente d

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3

Torres Lozada, Patricia, Yazmín Stefhany Carabalí Rivera, and Luz Edith Barba Ho. "Determination of leachate toxicity through acute toxicity using Daphnia pulex and Anaerobic Toxicity Assays." Ingeniería e Investigación 37, no. 1 (2017): 16. http://dx.doi.org/10.15446/ing.investig.v37n1.54220.

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The municipal solid waste (MSW) of large cities, in particular in developing countries, is mainly disposed of in landfills (LFs), whose inadequate management generates the emission of greenhouse gases and the production of leachates with high concentrations of organic and inorganic matter and occasionally heavy metals. In this study, the toxicity of the leachates from an intermediate-age municipal landfill was evaluated by ecotoxicity and anaerobic digestion tests. The acute toxicity assays with Daphnia pulex presented a toxic unit (TU) value of 49.5%, which indicates that these leachates shou

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Speece, R. E., G. F. Parkin, and S. K. Bhattacharya. "Modelling Toxic Response of Anaerobic Treatment." Water Science and Technology 18, no. 12 (1986): 27–39. http://dx.doi.org/10.2166/wst.1986.0161.

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The toxicity response of the anaerobic treatment process can be modelled from a number of different approaches. Toxicity affects the growth rate and the effluent substrate concentration and can be modelled by competitive and uncompetitive inhibition. The biological safety factor is reduced. Most toxicants exhibit reversible toxicity, which is quite significant. Acclimation is noted to some toxicants. Molecular structure can be used to model and predict toxicity.

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Barthet, Gael, Anastasios Georgakopoulos та Nikolaos K. Robakis. "Cellular mechanisms of γ-secretase substrate selection, processing and toxicity". Progress in Neurobiology 98, № 2 (2012): 166–75. http://dx.doi.org/10.1016/j.pneurobio.2012.05.006.

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6

Jung, Keumhee, Gabriel Bitton, and Ben Koopman. "Selective assay for heavy metal toxicity using a fluorogenic substrate." Environmental Toxicology and Chemistry 15, no. 5 (1996): 711–14. http://dx.doi.org/10.1002/etc.5620150515.

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7

He, Jingting, Junfeng Zhai, Dengbin Yu, et al. "A respiration substrate-less isolation method for acute toxicity assessment." Chemosphere 244 (April 2020): 125511. http://dx.doi.org/10.1016/j.chemosphere.2019.125511.

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8

Bardaweel, Sanaa K., Rana Abu-Dahab, and Nour F. Almomani. "An in vitro based investigation into the cytotoxic effects of D-amino acids." Acta Pharmaceutica 63, no. 4 (2013): 467–78. http://dx.doi.org/10.2478/acph-2013-0032.

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Abstract In the present study, cytotoxic effects of D-Ala, D-Pro and D-Lys are demonstrated. In an effort to study the possible mechanisms of the observed cytotoxicity, catalase activity, H2O2 generation, and apoptotic activity were measured in HeLa and MCF-7 cell lines. Although D-Lys is a poor substrate for DAO and therefore low H2O2 was detected, it was shown to provoke severe impairment of cellular integrity and survival. Interestingly, a very good substrate for DAO, such as D-Pro, did not substantially reduce cell viability. On the other hand, a moderate substrate for DAO, represented by

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9

Paul, John H., and Wade H. Jeffrey. "The effect of surfactants on the attachment of estuarine and marine bacteria to surfaces." Canadian Journal of Microbiology 31, no. 3 (1985): 224–28. http://dx.doi.org/10.1139/m85-043.

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The effect of dilute surfactants on bacterial attachment to hydrophilic and hydrophobic substrata has been investigated. Triton X-100 at 0.002% completely inhibited attachment to polystyrene, a hydrophobic surface, for 10 of 11 isolates and all isolates at 0.01%. This concentration of surfactant also caused displacement of previously attached Vibrio proteolytica cells. Attachment to glass, a hydrophilic substratum, was far less sensitive to surfactants, and one isolate showed no inhibition at 0.1%, the highest concentration employed. Concentrations of surfactant sufficient to completely inhibi

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10

Mann, R. A. "Phosphorus adsorption and desorption characteristics of constructed wetland gravels and steelworks by-products." Soil Research 35, no. 2 (1997): 375. http://dx.doi.org/10.1071/s96041.

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Laboratory phosphorus (P) adsorption and desorption experiments were conducted on 9 substrata to evaluate their potential to remove P from sewage effluent. The substrata comprised 2 gravels used in constructed wetlands, Hawkesbury sandstone, and 6 steelworks by-products: granulated blast furnace slag, blast furnace slag, steel slag, fly ash, bottom ash, and coal wash. The studies involved ion-exchange experiments and calculation of Langmuir and Freundlich adsorption isotherms and column adsorption/desorption trials. The ability to adsorb P was then correlated to the physico-chemical attributes

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11

Tune, B. M., and C. Y. Hsu. "The renal mitochondrial toxicity of beta-lactam antibiotics: in vitro effects of cephaloglycin and imipenem." Journal of the American Society of Nephrology 1, no. 5 (1990): 815–21. http://dx.doi.org/10.1681/asn.v15815.

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The nephrotoxic beta-lactam antibiotics cephaloridine, cephaloglycin, and imipenem produce irreversible injury to renal mitochondrial anionic substrate uptake and respiration after 1 to 2 h of in vivo exposure. Toxicity during in vitro exposure is nearly identical but is immediate in onset and is reversed by the mitochondria being washed or the substrate concentrations being increased. A model of injury that accounts for these findings proposes that the beta-lactams fit carriers for mitochondrial substrate uptake, causing inhibition that is initially reversible and becomes irreversible as the

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12

Repečkienė, Juratė, Dalė Pečiulytė, Algimantas Paškevičius, Olga Salina, Karolis Jankevičius та Rapolas Liužinas. "MICROBIOLOGICAL REDUCTION OF MONOETHANOLAMINE WASTE TOXICITY / MIKROBIOLOGINIS MONOETILAMINO ATLIEKŲ TOKSIŠKUMO MAŽINIMO BŪDAS / МИКРОБИОЛОГИЧЕСКОЕ СНИЖЕНИЕ ТОКСИЧНОСТИ МОНОЭТИЛЕНАМИННЫХ ОТХОДОВ". Journal of Environmental Engineering and Landscape Management 19, № 4 (2011): 287–95. http://dx.doi.org/10.3846/16486897.2011.634054.

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Aims of the investigation were to evaluate toxicity of monoethanolamine waste to various microorganisms and plants; and to search for means accelerating waste biodegradation. The results of the investigation show toxic effects of MEA waste on bacteria, fungi and plant seeds at rather low concentrations. Some microorganisms are able to adapt to the pollutant in the mixed substrates of the MEA and peat. During the experiment, density of the bacterial and fungal populations in the MEA and peat mixed substrates increased, followed by the intensive acidifying process of the substrates and by the de

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13

Rodrigues, Gustavo Araújo, Breno De Jesus Pereira, Anacleto Ranulfo dos Santos, Francielle Medeiros Costa, and Gilvanda Leão dos Anjos. "PIGEON PEA INITIAL GROWTH UNDER DIFFERENT CONCENTRATIONS OF ALUMINUM AND COMMERCIAL SUBSTRATE." JOURNAL OF NEOTROPICAL AGRICULTURE 7, no. 4 (2020): 1–6. http://dx.doi.org/10.32404/rean.v7i4.5046.

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The incorporation of organic substrate into the soil can reduce aluminum toxicity in pigeon pea (Cajanus cajan (L.) Millsp.) plants, making it a viable alternative for use by small farmers in acidic soil regions such as the northeast semi-arid regions of Brazil that contain toxic aluminum in the soil. The aim of this study was to evaluate the effect of increasing aluminum doses and different commercial substrate concentrations on the initial growth of the pigeon pea. The experiment was undertaken in a greenhouse using a completely randomized design with a 5 × 3 factorial scheme. The first fact

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Mendes, Tiago Pacheco, Fábio Luiz de Oliveira, Marcelo Antonio Tomaz, Wagner Nunes Rodrigues, and Ariany das Graças Teixeira. "Aluminum toxicity effect on the initial growth of yacon plantlets." Revista Ceres 65, no. 2 (2018): 120–26. http://dx.doi.org/10.1590/0034-737x201865020002.

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ABSTRACT The increasing consumption of yacon potato has raised worldwide interest in its crop and generated demand for scientific elucidations of several factors associated to its agricultural management. Among the demands, there are the studies related to the effects of aluminum (Al3+) on the development of yacon plants. Thus, this study was developed to evaluate the effects of aluminum on budding and initial growth of yacon plantlets. The experiment was carried out in a completely randomized block design, with three replications and six aluminum contents in the substrate: 0, 10, 25, 50, 100,

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15

Samara de Assis Carneiro, Rayza, and Cristiane Ramos Vieira. "Produção de Mudas de Espécies Florestais em Substrato Contendo Esterco de Aves ou Esterco Bovino." Ensaios e Ciência C Biológicas Agrárias e da Saúde 24, no. 4 (2020): 386–95. http://dx.doi.org/10.17921/1415-6938.2020v24n4p386-395.

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A produção de mudas contempla etapas que podem demandar maiores, ou menores investimentos financeiros, como é a adubação. Caso esta se faça totalmente com base em adubos minerais granulados, essa fase será a mais cara do processo. Uma forma de minimizar estes custos é com a utilização de materiais orgânicos que podem ser ricos em nutrientes e condicionar fisicamente o substrato. O objetivo deste artigo foi realizar uma revisão bibliográfica para apresentar as características dos estercos bovino e de aves, utilizados como componentes de substratos, na produção de mudas florestais. Para essa rev

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Bucher, Annette S., and Manfred K. Schenk. "Characterization of Phytoavailable Copper in Compost-Peat Substrates and Determination of a Toxicity Level." Journal of the American Society for Horticultural Science 125, no. 6 (2000): 765–70. http://dx.doi.org/10.21273/jashs.125.6.765.

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Heavy metal-sensitive `Express Orchid' petunias (Petunia ×hybrida Hort Vilm.-Andr. `Express Orchid') were grown in substrates of 2 green yard waste compost: 3 peat (v/v) with target Cu contents of 100 and 200 mg·kg-1 at varying pH. Iron supply was also varied. Copper contents of the substrate were determined by H2O, NH4NO3, NH4OAc, CaCl2, CaCl2-DTPA, and aqua regia extraction. Plant Cu concentration increased with increasing Cu supply and decreasing pH, indicating that Cu phytoavailability depended on substrate pH. Extraction of fresh substrates with CaCl2-DTPA provided a good prediction of pl

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17

Guisasola, A., J. A. Baeza, J. Carrera, C. Casas, and J. Lafuente. "An off-line respirometric procedure to determine inhibition and toxicity of biodegradable compounds in biomass from an industrial WWTP." Water Science and Technology 48, no. 11-12 (2004): 267–75. http://dx.doi.org/10.2166/wst.2004.0858.

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Determining whether a certain compound is toxic (or inhibitor) or not to a biomass of a WWTP is crucial in order to avoid WWTP malfunction. Respirometric techniques have been commonly used to assess the toxicity of a certain compound by evaluating the oxygen uptake rate (OUR) profile obtained when a pulse of substrate is added to endogenous biomass and comparing it with the OUR profile obtained when the pulse is a mixture of substrate and the possible toxic or inhibitor (PTI). However, when using this method with biodegradable compounds some difficulties arise because the PTI consumption impli

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Ahmad, Shama, Carl W. White, Ling-Yi Chang, Barbara K. Schneider, and Corrie B. Allen. "Glutamine protects mitochondrial structure and function in oxygen toxicity." American Journal of Physiology-Lung Cellular and Molecular Physiology 280, no. 4 (2001): L779—L791. http://dx.doi.org/10.1152/ajplung.2001.280.4.l779.

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Glutamine is an important mitochondrial substrate implicated in the protection of cells from oxidant injury, but the mechanisms of its action are incompletely understood. Human pulmonary epithelial-like (A549) cells were exposed to 95% O2 for 4 days in the absence and presence of glutamine. Cell proliferation in normoxia was dependent on glutamine, and glutamine deprivation markedly accelerated cell death in hyperoxia. Glutamine significantly increased cellular ATP levels in normoxia and prevented the loss of ATP in hyperoxia seen in glutamine-deprived cells. Mitochondrial membrane potential a

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19

Vallecillo, A., P. A. Garcia-Encina, and M. Pen˜a. "Anaerobic Biodegradability and Toxicity of Chlorophenols." Water Science and Technology 40, no. 8 (1999): 161–68. http://dx.doi.org/10.2166/wst.1999.0412.

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Anaerobic biodegradation of several chlorophenol compounds under different conditions was studied. The experiments were carried out in batch and continuous processes and supplying or not an external carbon source. In the batch bioassays the observed reductive dechlorination with external carbon was greater than without external carbon source. The addition of the external carbon source stimulated the dechlorination, stabilized the process, and ensured the presence of sufficient amount of active biomass. The continuous process was evaluated in a fluidized bed reactor fed with synthetic wastewate

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Batova, Ayse, Howard Cottam, John Yu, Mitchell B. Diccianni, Carlos J. Carrera та Alice L. Yu. "EFA (9-β-D-erythrofuranosyladenine) is an effective salvage agent for methylthioadenosine phosphorylase-selective therapy of T-cell acute lymphoblastic leukemia with L-alanosine". Blood 107, № 3 (2006): 898–903. http://dx.doi.org/10.1182/blood-2005-06-2430.

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AbstractThe deficiency of methylthioadenosine phosphorylase (MTAP) in T-cell acute lymphoblastic leukemia (T-ALL) and other cancers, while constitutively expressed in normal cells, allows for selective therapy using L-alanosine, an inhibitor of de novo AMP synthesis. We demonstrate that MTAP- T-ALL cells obtained at relapse are as sensitive to L-alanosine toxicity as diagnosis samples. The therapeutic index of L-alanosine can be increased by the use of a MTAP substrate, which protects MTAP+ normal cells. Since MTAP substrates MTA and 5′deoxyadenosine are prone to toxicities associated with ade

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Jung, Keumhee, Gabriel Bitton, and Ben Koopman. "SELECTIVE ASSAY FOR HEAVY METAL TOXICITY USING A FLUOROGENIC SUBSTRATE—Short Communication." Environmental Toxicology and Chemistry 15, no. 5 (1996): 711. http://dx.doi.org/10.1897/1551-5028(1996)015<0711:scsafh>2.3.co;2.

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Yun, Seung Pil, Hyojung Kim, Sangwoo Ham, et al. "VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2." Cell Death & Disease 8, no. 4 (2017): e2741-e2741. http://dx.doi.org/10.1038/cddis.2017.157.

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Mizutani, Takaharu, Kazuo Kanaya, and Kazutaka Tanabe. "Selenophosphate as a substrate for mammalian selenocysteine synthase, its stability and toxicity." BioFactors 9, no. 1 (1999): 27–36. http://dx.doi.org/10.1002/biof.5520090105.

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Tynecka, Z., A. Malm, U. Kosikowska, and A. Kot. "Substrate-dependent cadmium toxicity affecting energy-linked K+/86Rb transport inStaphylococcus aureus." Folia Microbiologica 43, no. 6 (1998): 617–22. http://dx.doi.org/10.1007/bf02816378.

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25

Li, Xiao-Fang, Jin-Wei Sun, Yi-Zong Huang, Yi-Bing Ma, and Yong-Guan Zhu. "Copper toxicity thresholds in Chinese soils based on substrate-induced nitrification assay." Environmental Toxicology and Chemistry 29, no. 2 (2010): 294–300. http://dx.doi.org/10.1002/etc.51.

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26

Paulilo, Maria Terezinha Silveira, Flávia Simão Lapa, and Miriam de Barcellos Falkenberg. "Effect of light intensity and growth substratum on plant development and production of secondary metabolites in Cordia curassavica (Jacq.) Roem. & Schult." Revista Árvore 34, no. 3 (2010): 417–23. http://dx.doi.org/10.1590/s0100-67622010000300005.

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Cordia curassavica (Jacq.) Roem. & Schult. (Boraginaceae), also referred to as Cordia verbenacea DC, has been traditionally used for medicinal purposes. This study was driven to verify the behavior of the species in similar conditions to its natural environment, such as high light intensity and sandbank soil, and in conditions of low light intensity and fertilized substratum (dystroferric red nitosoil plus earthworm humus). The growth of the plant, the income of leaf crude extracts and, in the alcoholic extract, the number of substances found in thin layer cromatography and the toxicity of

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27

Demko, Martin, Lukáš Chrást, Pavel Dvořák, Jiří Damborský, and David Šafránek. "Computational Modelling of Metabolic Burden and Substrate Toxicity in Escherichia coli Carrying a Synthetic Metabolic Pathway." Microorganisms 7, no. 11 (2019): 553. http://dx.doi.org/10.3390/microorganisms7110553.

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In our previous work, we designed and implemented a synthetic metabolic pathway for 1,2,3-trichloropropane (TCP) biodegradation in Escherichia coli. Significant effects of metabolic burden and toxicity exacerbation were observed on single cell and population levels. Deeper understanding of mechanisms underlying these effects is extremely important for metabolic engineering of efficient microbial cell factories for biotechnological processes. In this paper, we present a novel mathematical model of the pathway. The model addresses for the first time the combined effects of toxicity exacerbation

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Poloznikov, Andrey A., Sergey V. Nikulin, Arpenik A. Zakhariants, et al. "“Branched Tail” Oxyquinoline Inhibitors of HIF Prolyl Hydroxylase: Early Evaluation of Toxicity and Metabolism Using Liver-on-a-chip." Drug Metabolism Letters 13, no. 1 (2019): 45–52. http://dx.doi.org/10.2174/1872312813666181129100950.

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Background: “Branched tail” oxyquinolines, and adaptaquin in particular, are potent HIF prolyl hydroxylase inhibitors showing promising results in in vivo hemorrhagic stroke models. The further improvement of the potency resulted in identification of a number of adaptaquin analogs. Early evaluation of toxicity and metabolism is desired right at the step of lead selection. Objective: The aim of the study is to characterize the toxicity and metabolism of adaptaquin and its new improved analogs. Method: Liver-on-a-chip technology with differentiated HepaRG cells followed by LC-MS detection of the

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Zhao, Xuefei, Laura Jarboe, and Zhiyou Wen. "Utilization of pyrolytic substrate by microalga Chlamydomonas reinhardtii: cell membrane property change as a response of the substrate toxicity." Applied Microbiology and Biotechnology 100, no. 9 (2016): 4241–51. http://dx.doi.org/10.1007/s00253-016-7439-2.

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Owen, W. Garrett, Brian E. Whipker, Josh B. Henry, Paul Cockson, and Hunter Landis. "Low Substrate pH–Induced Iron/Manganese Toxicity of New Guinea Impatiens: A Diagnostic Guide." Plant Health Progress 19, no. 4 (2018): 324–28. http://dx.doi.org/10.1094/php-06-18-0031-dg.

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New Guinea impatiens (Impatiens hawkeri) are popular bedding plants, but the knowledge of diagnosing abiotic disorders during greenhouse production is evolving. Symptomology of nutrient deficiencies and excessive fertilization have been extensively documented. Exact symptomology of low substrate pH (<5.5) and toxic iron (Fe) and/or manganese (Mn) leaf tissue levels are not defined or photographed, thereby aiding in diagnosis. Therefore, the objective of the diagnostic guide was to photograph symptomology and document the tissue levels in New Guinea impatiens to provide a definitive guide of

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Vitcheva, Vessela, Magdalena Kondeva-Burdina, and Mitka Mitcheva. "D-Amphetamine Toxicity in Freshly Isolated Rat Hepatocytes: A Possible Role of CYP3A." Archives of Industrial Hygiene and Toxicology 60, no. 2 (2009): 139–45. http://dx.doi.org/10.2478/10004-1254-60-2009-1912.

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D-Amphetamine Toxicity in Freshly Isolated Rat Hepatocytes: A Possible Role of CYP3AThe aim of this study was to trace D-amphetamine toxicity in isolated rat hepatocytes and to elucidate a possible involvement of CYP3A in the mechanisms of its toxicity. To this end, male Wistar rats were treated with nifedipine (5 mg kg-1i.p., 5 days), a substrate and inducer of CYP3A. Hepatocytes isolated from nifedipine-treated and control rats were incubated with D-amphetamine at a concentration of 100 μmol L-1, which was determined to be an average toxic concentration (TC50) for the compound. To evaluate t

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Benouis, S., H. A. Reguieg Yssaad, E. H. Bouziani, and I. Khedim. "Physiological responses of Vicia faba to copper toxicity." Agricultural Science and Technology, Volume 13, Issue 1 (March 2021): 63–69. http://dx.doi.org/10.15547/ast.2021.01.012.

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Abstract. Copper plays an important role in multiple plant physiological processes including photosynthesis and protein synthesis. Excess copper in tissues leads to physiological and biochemical disturbances. In order to determine the physiological response of Vicia faba L. to copper toxicity, two varieties (Sidi Aïch and Super Aguadulce) were grown in a substrate of sand and compost (3V/V) and contaminated by different doses of Cu (0, 80, 160, 240, 320, 400 mg kg-1). Dose rates ≥160 mg kg-1 led to the accumulation of copper in roots and shoots, in turn leading to decreases in photosynthetic a

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L. B. Moody, R. T. Burns, S. T. Sell, and G. Bishop. "Using Anaerobic Toxicity Assays to Aid in Co-substrate Selection for Co-digestion." Applied Engineering in Agriculture 27, no. 3 (2011): 441–47. http://dx.doi.org/10.13031/2013.37070.

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McAuley, Erin, Bhavana Mohanraj, Theresa Phamduy, George E. Plopper, David T. Corr, and Douglas B. Chrisey. "Evaluation of electric cell-substrate impedance sensing for the detection of nanomaterial toxicity." International Journal of Biomedical Nanoscience and Nanotechnology 2, no. 2 (2011): 136. http://dx.doi.org/10.1504/ijbnn.2011.040998.

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Li, Ji, Yizong Huang, Ying Hu, et al. "Lead toxicity thresholds in 17 Chinese soils based on substrate-induced nitrification assay." Journal of Environmental Sciences 44 (June 2016): 131–40. http://dx.doi.org/10.1016/j.jes.2015.09.019.

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Kosalwat, Prapimpan, and Allen W. Knight. "Acute toxicity of aqueous and substrate-bound copper to the midge,Chironomus decorus." Archives of Environmental Contamination and Toxicology 16, no. 3 (1987): 275–82. http://dx.doi.org/10.1007/bf01054944.

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Kalme, S. D., S. U. Jadhav, G. K. Parshetti, and S. P. Govindwar. "Biodegradation of Green HE4B: Co-substrate effect, biotransformation enzymes and metabolite toxicity analysis." Indian Journal of Microbiology 50, no. 2 (2010): 156–64. http://dx.doi.org/10.1007/s12088-010-0001-5.

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Letourneau, F., and P. Villa. "Saccharomyces yeast growth on beet molasses effects of substrate concentration on alcohol toxicity." Biotechnology Letters 9, no. 1 (1987): 53–58. http://dx.doi.org/10.1007/bf01043394.

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Bailey, Christopher M., Rajesh Kasiviswanathan, William C. Copeland та Karen S. Anderson. "R964C Mutation of DNA Polymerase γ Imparts Increased Stavudine Toxicity by Decreasing Nucleoside Analog Discrimination and Impairing Polymerase Activity". Antimicrobial Agents and Chemotherapy 53, № 6 (2009): 2610–12. http://dx.doi.org/10.1128/aac.01659-08.

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ABSTRACT The R964C mutation of human DNA polymerase γ was recently linked to stavudine (d4T)-mediated mitochondrial toxicity. We utilized pre-steady-state kinetics to determine the effect of this mutation on incorporation of natural substrate dTTP and the active metabolite of d4T (d4TTP). The R964C polymerase γ holoenzyme demonstrated a 33% decrease in dTTP incorporation efficiency and a threefold-lower d4TTP discrimination relative to that of the wild-type polymerase γ, providing a mechanistic basis for genetic predisposition to nucleoside reverse transcriptase inhibitor toxicity.

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Sohl, Christal D., Kamlendra Singh, Rajesh Kasiviswanathan та ін. "Mechanism of Interaction of Human Mitochondrial DNA Polymerase γ with the Novel Nucleoside Reverse Transcriptase Inhibitor 4′-Ethynyl-2-Fluoro-2′-Deoxyadenosine Indicates a Low Potential for Host Toxicity". Antimicrobial Agents and Chemotherapy 56, № 3 (2011): 1630–34. http://dx.doi.org/10.1128/aac.05729-11.

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ABSTRACTThe potent antiretroviral 4′-ethynyl-2-fluoro-2′-deoxyadenosine (EFdA) is a promising experimental agent for treating HIV infection. Pre-steady-state kinetics were used to characterize the interaction of EFdA-triphosphate (EFdA-TP) with human mitochondrial DNA polymerase γ (Pol γ) to assess the potential for toxicity. Pol γ incorporated EFdA-TP 4,300-fold less efficiently than dATP, with an excision rate similar to ddATP. This strongly indicates EFdA is a poor Pol γ substrate, suggesting minimal Pol γ-mediated toxicity, although this should be examined under clinical settings.

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Inanc, B., B. Calli, K. Alp, F. Ciner, B. Mertoglu, and I. Ozturk. "Toxicity assessment on combined biological treatment of pharmaceutical industry effluents." Water Science and Technology 45, no. 12 (2002): 135–42. http://dx.doi.org/10.2166/wst.2002.0419.

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This paper describes the wastewater characterization and aerobic/anaerobic treatability (oxygen uptake rate and biogas production measurement) of chemical-synthesis based pharmaceutical industry effluents in a nearby baker's yeast industry treatment plant. Preliminary experiments by the industry had indicated strong anaerobic toxicity. On the other hand, aerobic treatability was also uncertain due to complexity and unknown composition of the wastewater. The work in this study has indicated that the effluents of the pharmaceutical industry can be treated without toxicity in the aerobic stage of

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S.Windsor, Eric, Dale E.Newbury, John D.Kessler, and Peter H.Chi. "Boron Substrates for Particulate X-Ray Microanalysis." Microscopy and Microanalysis 5, S2 (1999): 920–21. http://dx.doi.org/10.1017/s143192760001792x.

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Sample substrates for x-ray microanalysis of particles should be chemically simple and composed of low atomic number elements. Substrates meeting these requirements will generate a minimum number of low energy x-ray peaks that should not interfere with spectra generated by the particles of interest. Elemental carbon fulfills these requirements and carbon planchets are used for the majority of work involving x-ray microanalysis of particles. When particles of interest are carbonaceous, alternate substrates must be sought. Beryllium planchets have traditionally been used for the analysis of carb

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Kalogeropulou, Alexia F., Jing Zhao, Marc F. Bolliger, et al. "P62/SQSTM1 is a novel leucine-rich repeat kinase 2 (LRRK2) substrate that enhances neuronal toxicity." Biochemical Journal 475, no. 7 (2018): 1271–93. http://dx.doi.org/10.1042/bcj20170699.

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Autosomal-dominant, missense mutations in the leucine-rich repeat protein kinase 2 (LRRK2) gene are the most common genetic predisposition to develop Parkinson's disease (PD). LRRK2 kinase activity is increased in several pathogenic mutations (N1437H, R1441C/G/H, Y1699C, G2019S), implicating hyperphosphorylation of a substrate in the pathogenesis of the disease. Identification of the downstream targets of LRRK2 is a crucial endeavor in the field to understand LRRK2 pathway dysfunction in the disease. We have identified the signaling adapter protein p62/SQSTM1 as a novel endogenous interacting

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Ghaleb, Aiban Abdulhakim Saeed, Shamsul Rahman Mohamed Kutty, Yeek-Chia Ho, et al. "Response Surface Methodology to Optimize Methane Production from Mesophilic Anaerobic Co-Digestion of Oily-Biological Sludge and Sugarcane Bagasse." Sustainability 12, no. 5 (2020): 2116. http://dx.doi.org/10.3390/su12052116.

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Oily-biological sludge (OBS) generated from petroleum refineries has high toxicity. Therefore, it needs an appropriate disposal method to reduce the negative impacts on the environment. The anaerobic co-digestion process is an effective method that manages and converts organic waste to energy. For effective anaerobic digestion, a co-substrate would be required to provide a suitable environment for anaerobic bacteria. In oily-biological sludge, the carbon/nitrogen (C/N) ratio and volatile solids (VS) content are very low. Therefore, it needs to be digested with organic waste that has a high C/N

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Brown, Jessica A., Lindsey R. Pack, Jason D. Fowler, and Zucai Suo. "Pre-Steady-State Kinetic Analysis of the Incorporation of Anti-HIV Nucleotide Analogs Catalyzed by Human X- and Y-Family DNA Polymerases." Antimicrobial Agents and Chemotherapy 55, no. 1 (2010): 276–83. http://dx.doi.org/10.1128/aac.01229-10.

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ABSTRACTNucleoside reverse transcriptase inhibitors (NRTIs) are an important class of antiviral drugs used to manage infections by human immunodeficiency virus, which causes AIDS. Unfortunately, these drugs cause unwanted side effects, and the molecular basis of NRTI toxicity is not fully understood. Putative routes of NRTI toxicity include the inhibition of human nuclear and mitochondrial DNA polymerases. A strong correlation between mitochondrial toxicity and NRTI incorporation catalyzed by human mitochondrial DNA polymerase has been established bothin vitroandin vivo. However, it remains to

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Fdz-Polanco, F., P. Nieto, S. I. Pérez-Elvira, and M. Fdz-Polanco. "Automated manometric method to assess anaerobic toxicity of chemicals." Water Science and Technology 54, no. 2 (2006): 95–101. http://dx.doi.org/10.2166/wst.2006.491.

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Industrial additives eventually used for different purposes (antifoaming, cleaning, bactericides, antiscale, etc) are discharged to the wastewater treatment plant. The anaerobic toxicity of these commercial products is not provided by suppliers. A new manometric method is developed and tested to evaluate anaerobic toxicity or inhibition using four different commercial products. Antifoaming Cleron 6 (50–200 ppm), bactericide Divosan-forte (0.05–1.0% v/v), bleach (0.1–1.0% v/v) and cleaning agent Topax 66 (0.10–1.0% v/v). According to the different methods proposed in the literature, from the me

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Charlton-Menys, Valentine, Yifen Liu, and Paul N. Durrington. "Semiautomated Method for Determination of Serum Paraoxonase Activity Using Paraoxon as Substrate." Clinical Chemistry 52, no. 3 (2006): 453–57. http://dx.doi.org/10.1373/clinchem.2005.063412.

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Abstract Background: Serum paraoxonase (PON1) is an enzyme associated with HDL, and its ability to protect LDL from oxidation is one mechanism by which HDL protects against atherosclerosis. Low concentrations of PON1 are found in patients with type 2 diabetes or coronary heart disease. Serum PON1 activity may also be important in avoidance of organophosphate toxicity in industry. Methods: The generally accepted method for determining PON1 activity requires use of a recording spectrophotometer and is not suited to large numbers of samples; in addition, automation presents particular problems be

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Zhao, Libo, Jing Si, Yuan Wei, et al. "Toxicity of porcelain-fused-to-metal substrate to zebrafish ( Danio rerio ) embryos and larvae." Life Sciences 203 (June 2018): 66–71. http://dx.doi.org/10.1016/j.lfs.2018.04.019.

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Ramesh Reddy, G., G. R. Veera Babu, P. Reddanna, and C. S. Chetty. "Substrate-affinity relationship of succinate dehydrogenase in brain of albino rat during dieldrin toxicity." Ecotoxicology and Environmental Safety 18, no. 2 (1989): 141–44. http://dx.doi.org/10.1016/0147-6513(89)90074-2.

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Ablieieva, Iryna. "THEORETICAL SUBSTANTIATION OF THE PETROLEUM HYDROCARBONS DESTRUCTION BY SPECIFIC MICROFLORA USING ANAEROBIC DIGESTATE." Environmental Problems 5, no. 4 (2020): 191–201. http://dx.doi.org/10.23939/ep2020.04.191.

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Implementation of the proposed approach to bioremediation of oil-contaminated soils provides an intensification of the hydrocarbons degradation process biologically using a digestate as a bio-stimulant, contributes to the production of an ecologically safe substrate, and excludes its toxicity to living organisms due to the degradation of petroleum hydrocarbons.

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