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Dissertations / Theses on the topic 'Toxicity Evaluation'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Elkin, Naomi D. "Evaluation of biomarkers for testicular toxicity." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4412.

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Non-clinical safety assessment is essential during the drug development process in the pharmaceutical industry, and involves numerous, detailed in vitro and in vivo toxicology tests (general, reproductive and genetic), and safety pharmacology studies. The testis is a common organ for adverse drug effects leading to attrition of potential compounds. It would, therefore, be useful to detect testicular toxicity as early as possible in the drug development process. Histopathology is the standard method for assessing testis toxicity, but a biomarker for ‘early warning’ detection of testicular toxic

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2

Krigel, Arthur. "Ocular toxicity evaluation of LED lighting systems." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB167.

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Pas de résumé<br>The aim of the study was to evaluate in controlled retinal risk LED lighting conditions compared to other common household lighting such as CCFL or CFL, in standard lighting conditions, on different animal species pigmented and non-pigmented. At first, we characterized the conditions of adaptation before enlightenment. We found that housing conditions before the light exposure is a source of artifact. Indeed, the location of the cages in a ventilated cabinet and the period before stalling before illumination generates a variable response to retinal light toxicity. Then, we tes

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3

Mazzatorta, Paolo. "Evaluation of pesticide toxicity : a hierarchical QSAR approach to model the acute aquatic toxicity and avian oral toxicity of pesticides." Thesis, Open University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424819.

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The thesis aimed to extract information relevant to the hazard and risk assessment of pesticides. In particular, quantitative structure-activity relationship (QSAR) approaches have been used to build up a mathematical model able to predict the aquatic acute toxicity, Leso, and the avian oral toxicity, LDso, for pesticides. Ecotoxicological values were collected from several databases, and screened according to quality criteria. A hierarchical QSAR approach was applied for the prediction of acute aquatic toxicity. Chemical structures were encoded into molecular descriptors by an automated, seam

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4

Dissanayake, Kosala Nimanthi. "Evaluation of neuromuscular transmission in organophosphorus pesticide toxicity." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/15837.

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Organophosphorus (OP) pesticide toxicity is a global health problem. Respiratory failure due to neuromuscular transmission dysfunction accounts for about 300,000 deaths annually in rural Asia. However, the clinical manifestation is complex, and described in terms of acute, intermediate, and chronic syndromes. The underlying mechanism of toxicity is still unclear. OP pesticides contain inhibitors of acetylcholinesterase (AChE), for example dimethoate, emulsified in an organic solvent, typically cyclohexanone. A hypothesized mechanism is initial excitotoxicity through inhibition of acetylcholine

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5

CAPANNI, FRANCESCA. "TOXICITY EVALUATION OF PLASTIC NANOPARTICLES ON AQUATIC ORGANISMS." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/3008871.

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Plastics are an immense family of unique and versatile materials which play an essential role in modern society and are an indispensable part of our daily lives. With a global production of nearly 440 million tons in 2019, plastic waste has been described to accumulate in virtually any environment, from marine to freshwater ecosystems. The irreversibility and global ubiquity of marine plastic pollution has turned plastics into a potential planetary boundary threat. Nanoplastics (NPs) represent the smallest fraction of plastic litter and can result in the environment as the degradation products

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6

Galletti, Andrea. "Toxicity evaluation of TiO2 Nanoparticles embedded in consumer products." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2016. http://amslaurea.unibo.it/11285/.

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Lo studio è orientato alla determinazione dei rischi tossici posti dalle nanoparticelle di diossido di titanio rilasciate in ambiente marino. L’organismo modello utilizzato per questo studio è la diatomea Thalassiosira pseudonana, la quale è stata scelta per la sua semplicità biologica unita alla fondamentale rilevanza nella catena alimentare e nell’ecosistema marino. Oltre alle nanoparticelle prodotte industrialmente, questo studio ha lo scopo di determinare e confrontare la tossicità delle nanoparticelle utilizzate in alcuni prodotti di cura personale (in particolare crema solare e dentifri

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7

Silva, Ana Rita Rego Gouveia. "Toxicity and bioremediation evaluation of TBT: bioassays with plants." Master's thesis, Universidade de Aveiro, 2011. http://hdl.handle.net/10773/5657.

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Mestrado em Biologia Aplicada - Toxicologia e Ecotoxicologia<br>A poluição ambiental é um problema que afecta todo o ecossistema. Os compostos orgânicos de estanho, e em particular o tributilestanho (TBT), estão amplamente dispersos, por terem uma variedade de aplicações, sendo utilizados como estabilizadores de cloreto de polivinila (PVC), em canalizações de água, como catalisadores, conservantes da madeira e em vários productos de consumo doméstico, como líquidos de limpeza, esponjas e papel. Devido à acção biocida do TBT, este composto era principalmente utilizado em tintas antivegetativas.

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8

Pecoraro, Roberta. "Toxicity evaluation of new engineered nanomaterials in model organisms." Doctoral thesis, Università di Catania, 2017. http://hdl.handle.net/10761/3998.

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According to the definition adopted by European Commission in 2011 a nanomaterial (NM) is a natural, incidental or manufactured material containing particles, in an unbound state or as an aggregate or as an agglomerate and where, for 50% or more of the particles in the number size distribution, one or more external dimensions is in the size range 1 nm-100 nm (European Commission, 2011/696/EU). NM exhibit peculiar characteristics (e.g. small size, large surface area to mass ratio, shape, surface charge, reactive surface groups, state of agglomeration) that confer them properties substantially

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9

Rueda, Juan. "Evaluation of The Biodegradability and Toxicity of PCA and mPCA." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5696.

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The main types of hypergolic propellants used at Kennedy Space Center (KSC) are hydrazine (HZ) and monomethylhydrazine (MMH). HZ and MMH are classified as hazardous materials and they are also known to be potentially carcinogenic to humans; therefore, handling these substances and their waste is strictly regulated. The wastes streams from HZ and MMH have been estimated to be the main hazardous wastes streams at KSC. Currently at KSC these wastes are first neutralized using citric acid and then they are transported on public roads for incineration as hazardous materials. A new method using alph

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10

Magee, Pamela Jane. "Evaluation of the efficacy and toxicity of novel fungal extracts." Thesis, University of Ulster, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322422.

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11

Zhou, Lulu. "Toxicity evaluation and medical application of multi-walled carbon nanotubes." Thesis, Cranfield University, 2015. http://dspace.lib.cranfield.ac.uk/handle/1826/9262.

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Carbon nanotubes (CNTs) are of special interest to industry and they have been increasingly utilised as advanced nanovectors in drug/gene delivery systems. They possess significant advantages including high surface area, welldefined morphologies, unique optical property, superior mechanical strength and thermal conductivity. However, despite their unique and advanced physicochemical properties, the low compatibility of some of those materials [e.g. multiwalled CNTs (MWCNTs)] in most biological and chemical environments has also generated some serious health and environment concerns. Chemical f

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12

Silva, Thilini Upekshika. "An Evaluation of Coating Material Dependent Toxicity of Silver Nanoparticles." Digital Commons @ East Tennessee State University, 2011. https://dc.etsu.edu/etd/1229.

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Silver nanoparticles (AgNPs) synthesized using numerous types of coating materials may exhibit different toxicity effects. The study evaluated coating material dependent toxicity by selecting 3 types of AgNP synthesis methods with different coating materials (citrate, polyvinyl pyrrolidone, and branched polyethyleneimine, coated AgNPs as citrate-AgNPs, PVP-AgNPs, and BPEI-AgNPs respectively). Two acute aquatic toxicity tests were performed; 48hr D. magna and MetPLATE E. coli toxicity tests. Significantly different toxicity effects were observed in D. magna test exhibiting lethal median concent

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13

COSTA, VICTOR SURERUS LEAL. "EVALUATION OF TOXICITY USING THE RESPIROMETRIC METHOD ON ACTIVATED SLUDGE PROCESSES." PONTIFÍCIA UNIVERSIDADE CATÓLICA DO RIO DE JANEIRO, 2009. http://www.maxwell.vrac.puc-rio.br/Busca_etds.php?strSecao=resultado&nrSeq=15510@1.

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COORDENAÇÃO DE APERFEIÇOAMENTO DO PESSOAL DE ENSINO SUPERIOR<br>Para a avaliação da toxicidade aguda através do método respirométrico, foram empregados quatro compostos intoxicantes: Cu2+, fenol, surfactante e antibiótico, em distintas concentrações, os quais foram mantidos em contato durante 15 minutos com quatro tipos de lodo ativado: um oriundo de uma indústria farmacêutica, dois provenientes de indústria alimentícia e o outro aclimatado com efluente produzido sinteticamente. O reator biológico experimental foi montado e operado de modo contínuo para simular as condições encontradas nas ind

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14

Shannon, Robert David. "Evaluation of a mitochondrial test for the determination of chemical toxicity." Thesis, Virginia Tech, 1988. http://hdl.handle.net/10919/43054.

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The feasibility of using rat liver mitochondria respiratory parameters as a short-term toxicity test was investigated. Mitochondrial fractions were exposed to six concentrations of five chlorophenols. Respiratory parameters were measured and compared to control experiments. The toxicity of the chlorophenos, measured by the 50% uncoupling concentration (UC50), increased with increasing chloro substitution. The UC50 values for the five chlorophenols were compared to six physicochemical parameters for the same chlorophenols and high degrees of correlation were found (r >/- 0.890). The hig

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15

Wang, Yu. "The Application of Metabolomics to the Evaluation of the Celllular Toxicity." University of Akron / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=akron1397057769.

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16

Adesina-Georgiadis, Kyrillos N. "A metabonomic approach to the evaluation of xenobiotic metabolism and toxicity." Thesis, Imperial College London, 2015. http://hdl.handle.net/10044/1/32526.

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This thesis comprises of studies which collectively describe the development and application of novel metabonomic approaches to the investigation of xenobiotic metabolism and toxicity. Both computational and UPLC-MS technologies are critically evaluated to facilitate the development of rapid, robust and high throughput analytical approaches for the analysis of compounds in biological matrices, particularly applicable in the area of drug discovery. Pattern recognition statistical modelling approaches were employed on both a small scale metabolism study of diclofenac and a large toxicology of ac

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17

Di, Cesare Silvia. "Anticiper les effets des pesticides sur la santé des travailleurs agricoles sur la base des pratiques réelles : le cas des plantations de banane." Thesis, Montpellier, 2018. http://www.theses.fr/2018MONTG016/document.

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Les écosystèmes et les personnes sont exposés chaque jour à de multiples facteurs de stress chimiques par l'intermédiaire de multiples voies et voies en raison de la croissance économique et démographique. Considérant que l'utilisation de pesticides est particulièrement susceptible de nuire à la santé sur le lieu de travail, nous avons décidé de concevoir une méthode dédiée. Ce projet de thèse vise à développer une méthode pour examiner les effets comparatifs de différents systèmes de production agricole sur la santé des opérateurs à cause des pesticides. L'objectif est de permettre l'évaluati

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18

Peric, Brezana. "Evaluation of (eco)toxicity and biodegradability of short aliphatic protic ionic liquids." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285632.

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Ionic liquids (ILs) are a fairly new and very promising group of compounds. They are often considered as environmentally benign substitutes for traditional volatile organic solvents due to their attractive properties and physicochemical characteristics (e.g. non-volatility, high thermal stability and very good and versatile solving capacity). The ILs are salts composed entirely of ions (cations and anions) with a melting point below 100°C and they are liquid in a wide range of temperatures. The ILs are usually described as "green", but they are chemical products, and as such have to fulfill th

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19

Silwana, Bongiwe. "Heavy and precious metal toxicity evaluation using a horseradish peroxidase immobilised biosensor." University of the Western Cape, 2012. http://hdl.handle.net/11394/4619.

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>Magister Scientiae - MSc<br>Environmental pollution is always the hottest topic in public conversation and one of the most concerned aspects of human health. The thin film sputtered microelectrode devices have been developed to improve the quality of human health, by offering better monitoring capabilities. This thesis is divided into three parts and the studies were performed on chemical sensor technology currently available and under development using modified methods. In the first part of this thesis: (i) the studies are related to synthesis, characterization and polymerisation of polyanil

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20

Harwood, Amanda D. "Temperature as a toxicity identification evaluation tool for pyrethroid insecticides : toxicokinetic confirmation /." Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1594480611&sid=9&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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21

Van, der Schoor Ciska. "An in vivo and in ovo evaluation of the toxicity of Sibutramine." Diss., University of Pretoria, 2014. http://hdl.handle.net/2263/46008.

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Sibutramine hydrochloride monohydrate is a weight loss agent banned from most global markets due to reports of serious adverse events including death. It is classified as a serotonin-norepinephrine reuptake inhibitor and acts within the central nervous system by inhibiting the reuptake of these neurotransmitters essentially influencing satiety and also energy expenditure. Despite its ban, sibutramine is still available for use in some countries and is often an unlisted ingredient in herbal or natural weight loss products. This leads to the oblivious and unintentional consumption of this compou

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22

Giuliano, Francesco. "Evaluation of the activity and selectivity of non-steroidal anti-inflammatory drugs in vivo, ex vivo and in vitro." Thesis, Queen Mary, University of London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367598.

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23

Riley, Robert John. "An evaluation of the importance of metabolic activation and detoxication in drug toxicity." Thesis, University of Liverpool, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316895.

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24

Newcomb, Alden. "EVALUATION OF THE PHYSIOLOGICAL EFFECTS OF REDUCED HYDROXOCOBALAMIN ON ACUTE CARBON MONOXIDE TOXICITY." VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3560.

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Carbon monoxide (CO) poisoning represents a global health threat responsible for hundreds of thousands of hospital visits and tens of thousands of deaths annually. Oxygen therapy is the only current approved treatment for CO poisoning. Previous work published in the 1970’s and research conducted in the VCURES lab group has indicated that a reduced form of vitamin B12, hydroxocobalamin (B12r), can potentially serve as an antidote for CO poisoning by converting CO bound to hemoglobin to carbon dioxide (CO2) and mitigating the deleterious neurological effects of CO poisoning. For the first time i

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25

VIANELLO, ELEONORA. "In vivo evaluation of biomolecular mechanisms of bilirubin toxicity and pre-clinical therapies." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2908155.

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Introduction. Neonatal jaundice is a common and benign condition usually resolved during the first week of life. Neonates with very high level of unconjugated bilirubin (UCB), with an increase of the free bilirubin (Bf), may develop encephalopathy, with different grade of severity. Typical symptoms include motor disorder, auditory dysfunction, memory and learning deficits, reflecting selective damage respectively for cerebellum and basal ganglia, inferior colliculus, and hippocampus. Several studies reported that bilirubin may activate signal cascades that culminate to cell survival or death,

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26

Middendorf, Paul Joseph. "Development and evaluation of toxicity tests using Caenorhabditis elegans with reproduction, mutation, lethality, and behavior as end points." Diss., Georgia Institute of Technology, 1994. http://hdl.handle.net/1853/25201.

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27

Alderman, Lori A. "The evaluation and comparison of the extraction procedure toxicity test and the toxicity characteristic leaching procedure for the analysis of municipal wastewater sludges." Thesis, Virginia Tech, 1989. http://hdl.handle.net/10919/44103.

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<p>A viable sludge management alternative is land application of waste sludge. However, it is necessary to implement efficient monitoring and analysis of land applied sludges in order to assess potential health risks associated with this means of disposal.</p> <p> The State of Virginia is considering a proposal that requires land-applied wastewater sludges to undergo analysis by EPAâ s Toxicity Characteristic Leaching Procedure (TCLP) (EPA, 1986b) to determine if the sludge exhibits hazardous characteristics, which preclude land application as a management alternative. The method currently us

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28

Martins, Carla Maria Alves. "Toxicological effects of a pharmaceutical, simvastatin, in Gammarus locusta: histopathological evaluation." Master's thesis, Faculdade de Ciências e Tecnologia, 2013. http://hdl.handle.net/10362/10801.

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Dissertação para obtenção do Grau de Mestre em Engenharia do Ambiente<br>Pharmaceuticals and their derivatives are considered emerging organic contaminants of aquatic ecosystems, mostly by inputs from domestic and hospital effluents. The toxicological risk associated to these substances results essentially from their ability to act on a specific metabolic process. These substances have been revealed toxic to aquatic organisms as well as to the human populations that depend on these ecosystems. However, the toxicity of pharmaceuticals in the environment is not yet well known, such as for simva

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29

Mochan, Daria Galina. "Evaluation of a Rapid-screening Toxicity Test Using the Ciliate, Colpoda inflata (Stokes): Sensitivity and Bioavailability to Model Compounds." PDXScholar, 1996. https://pdxscholar.library.pdx.edu/open_access_etds/5165.

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Standard toxicity tests often require high costs for maintaining healthy cultures, so few test species are employed in routine ecotoxicological analysis. An alternative is the "battery of tests" approach involving using rapid toxicity tests for screening. Rapid-screening toxicity tests must display organism sensitivity, similarity in responses to other test organisms, relevancy to many circumstances, and repeatability. Protozoa are ideal candidates for rapid-screening bioassays. They are cosmopolitan, play important roles in ecosystems, and have high reproductive rates. Many protozoa can form

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30

Gadgil, Priyadarshini. "Evaluation of toxicity, mutagenicity, metabolism and formation of 2-dodecylcyclobutanone in irradiated ground beef." Diss., Manhattan, Kan. : Kansas State University, 2006. http://hdl.handle.net/2097/180.

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31

Bull, Sarah. "An evaluation of human cytochrome P450-transfected cell lines for metabolism-mediated toxicity studies." Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301703.

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32

Bertrand, Benoit. "Gold-based complexes : synthesis and evaluation as anticancer agents." Thesis, Dijon, 2015. http://www.theses.fr/2015DIJOS013.

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Depuis sa mise sur le marché à la fin des années 70, le Cisplatin est devenu l’un des pricipaux agents de chimiothérapie anticancéreuse. Actuellement, les composés à base de platine sont présents dans la majorité des coktails de chimiothérapie. Cependant, malgré leur succès clinique, ces composés présentent de nombreux inconvenients comme par exemple de nombreux et graves effets secondaires. Une des stratégies envisagées pour parer à ces défauts a été de remplacer le platine par d’autres métaux de transition. Parmi les différents métaux possibles, l’or est apparu comme particulièrement promett

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33

Zorloni, Alberto. "Evaluation of plants used for the control of animal ectoparasitoses in Southern Ethiopia (Oromiya and Somali regions)." Diss., University of Pretoria, 2008. http://hdl.handle.net/2263/26482.

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The burden of ticks in semi-arid lands of Ethiopia is not as pronounced as in some more humid areas of the continent. Nevertheless, the increasing recourse to chemicals smuggled by illegal traders has led to serious problems, including poisoning of humans and animals, discontinuous and irrational treatment regimens, tick-resistance to acaricidal products, loss of traditional knowledge and weakening of social structures. In order to encourage a resumption of the long-established ethnoveterinary practices, a survey on plants locally used in tick control was undertaken, and plant species used in

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34

Langford, Alan Maxwell. "An evaluation of exogenous thiols in rat lung slices and their effects on electrophile toxicity." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284231.

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35

Wang, Wenlong. "Studies on phenotypic and genotypic effects of xenoestrogens for integrated toxicity evaluation of environmental water." Kyoto University, 2018. http://hdl.handle.net/2433/232026.

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付記する学位プログラム名: グローバル生存学大学院連携プログラム<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(工学)<br>甲第21093号<br>工博第4457号<br>新制||工||1693(附属図書館)<br>京都大学大学院工学研究科都市環境工学専攻<br>(主査)教授米田稔, 教授高野裕久, 教授清水芳久<br>学位規則第4条第1項該当

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Reid, Eilidh M. "Evaluation of in vitro models for detection of hepatocyte toxicity induced by anti-cancer drugs." Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/30677.

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The aim of the studies included in this thesis is to evaluate <i>in vitro</i> models in which anti-cancer drug-induced hepatoxicity may be detected, to decrease the likelihood of hepatotoxic anticancer agents energin clinical development. <i>In vitro</i> models that represent hepatocytes, the major cell type in the liver, were selected, and were all of human origin. Murine models were not considered as there are significant inter-species differences that may impact on drug metabolism and therefore on drug-induced liver toxicity. The selected models comprised fresh and cryopreserved hepatocytes

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Gunkel, Ann Marilyn. "Evaluation of the Mutagenicity and Toxicity of Monoazo Dyes in Wastewater Effluents and Sludge Supernatants." University of Cincinnati / OhioLINK, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1021908155.

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Waits, Eric R. "Identification and evaluation of candidate genes associated with susceptibility to PCB-126 induced developmental toxicity." University of Cincinnati / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1305892257.

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Atchia, Sarah Miriam. "Toxicological studies in yeast species : production of cytochrome P450 and evaluation of carbon tetrachloride toxicity." Thesis, London Metropolitan University, 1993. http://repository.londonmet.ac.uk/3030/.

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In this work a number of yeast species were assessed for their potential in testing putative toxic and genotoxic compounds. Carbon tetrachloride (CCÍ4) was used as a model compound. Exposure of cells of Schizosaccharomyces pombe and Saccharomyces cerevisiae to carbon tetrachloride showed that the compound was toxic to the cells in a dose-dependent manner. Sch. pombe was more sensitive to the effects of carbon tetrachloride than S. -cerevisiae. Administration of the anti-oxidant a-tocopherot (vitamin E) to ceils of Sch, pombe treated with a toxic dose of carbon tetrachloride appeared to increa

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CAMMISULI, FRANCESCA. "Effects of nanomaterials on biological barriers, fetal and post-natal, and evaluation of epigenetic toxicity." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908037.

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Beyond the opportunities offered by nanotechnology research, there is a great need of studies aimed at understanding the harmful effects of general exposure to nanomaterials. My Ph.D. project aimed to be part of this evaluation, focusing on the interaction and the induction of possible toxic effects of two fibrous nanomaterials (asbestos and carbon nanotubes) at two critical internal biological barriers: the pleura and the placenta. The work is carried out by using advanced microscopy (µXRM and XRF) based on synchrotron radiation and other microscopes (SEM and AFM), and also conventional molec

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Parviz, Maryam Gross Guenter W. "Evaluation of zinc toxicity using neuronal networks on microelectrode arrays response quantification and entry pathway analysis /." [Denton, Tex.] : University of North Texas, 2007. http://digital.library.unt.edu/permalink/meta-dc-3928.

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Parviz, Maryam. "Evaluation of Zinc Toxicity Using Neuronal Networks on Microelectrode Arrays: Response Quantification and Entry Pathway Analysis." Thesis, University of North Texas, 2007. https://digital.library.unt.edu/ark:/67531/metadc3928/.

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Murine neuronal networks, derived from embryonic frontal cortex (FC) tissue grown on microelectrode arrays, were used to investigate zinc toxicity at concentrations ranging from 20 to 2000 mM total zinc acetate added to the culture medium. Continual multi-channel recording of spontaneous action potential generation allowed a quantitative analysis of the temporal evolution of network spike activity generation at specific zinc acetate concentrations. Cultures responded with immediate concentration-dependent excitation lasting from 5 to 50 min, consisting of increased spiking and enhanced, coordi

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Chen, Hong Carleton University Dissertation Biology. "Evaluation of the toxicity of Salmonella selective media and modes of action of selenite cystine medium." Ottawa, 1993.

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Davies-Coleman, H. D. (Heather D). "The growth and reproduction of the freshwater limpet Burnupia stenochorias (Pulmonata, Ancylidae), and an evaluation of its use as an ecotoxicology indicator in whole effluent testing." Thesis, Rhodes University, 2002. http://hdl.handle.net/10962/d1005389.

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For the protection of the ecological Reserve in South Africa, the proposed introduction of compulsory toxicity testing in the licensing of effluent discharges necessitates the development of whole effluent toxicity testing. The elucidation of the effects of effluent on the local indigenous populations of organisms is essential before hazard and risk assessment can be undertaken. The limpet Burnupia stenochorias, prevalent in the Eastern Cape of South Africa, was chosen to represent the freshwater molluscs as a potential toxicity indicator. Using potassium dichromate (as a reference toxicant) a

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45

Mehler, Wesley Tyler. "Identification of the sediment-associated contaminants in the Illinois River Complex using a toxicity identifcation evaluation (TIE)." OpenSIUC, 2009. https://opensiuc.lib.siu.edu/theses/134.

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The difficulty of assessing risk of sediment-associated contaminant mixtures to benthic ecosystems is often attributed to understanding the bioavailable fraction of each contaminant. These issues have led to the development of the toxicity identification evaluation (TIE). Past pore water TIE testing on Illinois River sediments has indicated that ammonia was the primary contaminant. The current study, however, suggests that ammonia is no longer the primary contaminant of concern, but rather non-polar organics, including polycyclic aromatic hydrocarbons, are the primary cause for toxicity in

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Roberts, Simon A. "Studies on the toxicity and metabolism of T-2 toxin in keratinocyte cultures : evaluation of a keratinocyte cell line and primary cultures as model systems for toxicity testing." Thesis, University of Surrey, 1989. http://epubs.surrey.ac.uk/847950/.

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With a view to establishing a model system for examining toxicity in skin, primary lingual keratinocyte cultures , a keratinocyte cell line and freshly isolated keratinocytes all derived from rat sub-lingual epithelium, were partially characterized both morphologically and enzymically and the toxicity and metabolism of the mycotoxin T-2, studied therein. A number of techniques for obtaining pure suspensions of sublingual keratinocytes (NCK) were examined and dispase is recommended for completely separating the epithelium from its dermis prior to trypsinization. Existing methods for the culture

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Hassan, Ibrahim Zubairu. "Evaluation of a current avian environmental toxicity guideline prescribed for pesticide evaluation for the prediction of the toxic effect of diclofenac in vultures." Diss., University of Pretoria, 2018. http://hdl.handle.net/2263/65524.

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Diclofenac was responsible for the death of millions of Gyps vultures (G. bengalensis, G. indicus and G. tenuirostris) in the Indian sub-region with the safety of the other members of nonsteroidal anti-inflammatory drugs (NSAIDs) being questionable. This has resulted in calls to test all the available NSAIDs for their vulture toxicity potential especially as studies have shown meloxicam to be safe; and ketoprofen, carprofen, flunixin and phenylbutazone as toxic. Unfortunately, due to the cost of testing, the time taken to establish toxicity reliably and the questionable ethics of repeat toxici

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48

Gu, Zu-Wei. "La cancerogenese chimique : aspect methodologique et evaluation du potentiel cancerogene." Paris 7, 1987. http://www.theses.fr/1987PA077051.

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Wimer, Adam Francis. "Resistance evaluation and management of Colorado potato beetle, Leptinotarsa decemlineata (Say), using novel chemistries." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/23232.

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Leptinotarsa decemlineata (Say) is the most important defoliating pest of potato Solanum tuberosum L., in North America and Europe. Management of this pest relies heavily on chemical control and insecticide resistance is a persistent problem. This phenomenon has increased the need for developing novel insecticides, resistance evaluation, and the development of alternative control strategies regarding this insect pest. From 2010 to 2013, field and lab experiments were conducted to evaluate the efficacy of a novel insecticide tolfenpyrad on L. decemlineata. In leaf-dip assays, tolfenpyrad wa

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Mehler, W. Tyler. "Identification of the sediment-associated contaminants in the Illinois River Complex using a toxicity identification evaluation (TIE) /." Available to subscribers only, 2009. http://proquest.umi.com/pqdweb?did=1966536661&sid=1&Fmt=2&clientId=1509&RQT=309&VName=PQD.

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