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Journal articles on the topic 'Toxicity Evaluation'

Author: Grafiati

Published: 4 June 2025

Last updated: 15 July 2025

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1

Hutchings, Matt, Ian Johnson, Elaine Hayes, et al. "Toxicity Reduction Evaluation, Toxicity Identification Evaluation and Toxicity Tracking in Direct Toxicity Assessment." Ecotoxicology 13, no. 5 (2004): 475–84. http://dx.doi.org/10.1023/b:ectx.0000035297.90620.73.

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2

Kumar, A. Satheesh, E. Manikgantan, and M. Ravichandran. "Safety Evaluation of Novel Siddha Herbal Formulation Maramanjal Chooranam: Acute and Subacute Toxicity Evaluations in Sprague Dawley Rats." Indian Journal Of Science And Technology 18, no. 9 (2025): 745–54. https://doi.org/10.17485/ijst/v18i9.3840.

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Background: Maramanjal Chooranam (MMC) is a novel siddha herbal medicine believed to offer therapeutic benefits such as anti-inflammatory and hepatoprotective effects. Evaluating the toxicological effects associated with herbal medicine is a crucial public health concern that must be addressed to better establish its clinical efficacy. Aim and Objective: Aim of the present study is to evaluate the acute and sub acute toxicity of MMC in Sprague Dawley rats, through biochemical, hematological, and histopathological analyses. Materials & Methods: The acute toxicity study involved administerin

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3

Sato, Shuzo. "Evaluation of ophthalmic toxicity." Folia Pharmacologica Japonica 131, no. 1 (2008): 50–54. http://dx.doi.org/10.1254/fpj.131.50.

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4

MTA, Abdel Wareth. "Evaluation of Fentonʼs Reagent Toxicity to Biomphalaria Alexandrina Snails". International Journal of Zoology and Animal Biology 3, № 1 (2020): 1–5. http://dx.doi.org/10.23880/izab-16000206.

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Fentonʼs reagent is considered a promising disinfecting agent as it has antimicrobial activity. In the present study, effective antifungal Fenton concentrations were investigated on Biomphalaria alexandrina snails as bio indicators of toxicity. Generally, they resulted in low mortality rate of snails, as only 20% mortality was recorded after 60 min of exposure. Also the activities of two antioxidant enzymes; catalase (CAT) and superoxide dismutase (SOD) in snails’ tissues were investigated at different time intervals. Although the activities of both enzymes were different from control group, t

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5

Lukavský, Jaromír, and Blahoslav Maršálek. "The evaluation of toxicity by a biosensor with immobilized algae." Algological Studies/Archiv für Hydrobiologie, Supplement Volumes 85 (June 6, 1997): 147–55. http://dx.doi.org/10.1127/algol_stud/85/1997/147.

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6

Liang, Ling, Menghua Cui, Mei Zhang, et al. "Nanoparticles' interference in the evaluation of in vitro toxicity of silver nanoparticles." RSC Advances 5, no. 82 (2015): 67327–34. http://dx.doi.org/10.1039/c5ra05863e.

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We have investigated the interference of silver nanoparticles on the toxicity evaluations. For accurate toxicity evaluation of nanoparticles, it would be very necessary to limit particle concentrations or choose other approaches free from the interference.

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7

Eckenfelder, W. W., and P. W. Lankford. "Protocol for Source Toxicity Evaluation." Water Science and Technology 25, no. 3 (1992): 45–54. http://dx.doi.org/10.2166/wst.1992.0076.

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Recent legislation in the United States is placing emphasis on the removal of priority pollutants and aquatic toxicity from industrial wastewaters. A protocol has been developed to select candidate technologies for specific effluent objectives. Wastewaters which are non-biodegradable and toxic are designated for source treatment. Design parameters for biological treatment are developed using a modified FBR test. The applicability of alternative physical-chemical technologies are discussed.

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8

Taketa, Yoshikazu. "Luteal toxicity evaluation in rats." Journal of Toxicologic Pathology 35, no. 1 (2022): 7–17. http://dx.doi.org/10.1293/tox.2021-0058.

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9

Hathcock, J. N., D. G. Hattan, M. Y. Jenkins, J. T. McDonald, P. R. Sundaresan, and V. L. Wilkening. "Evaluation of vitamin A toxicity." American Journal of Clinical Nutrition 52, no. 2 (1990): 183–202. http://dx.doi.org/10.1093/ajcn/52.2.183.

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10

Borges, F. A., N. T. Scognamiglio, C. Pedroso-de-Moraes, and C. A. Christofoletti. "Evaluation of citriculture sludge toxicity." Toxicology Letters 259 (October 2016): S138. http://dx.doi.org/10.1016/j.toxlet.2016.07.355.

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11

Lynch, Barry, Ryan Simon, and Ashley Roberts. "Subchronic toxicity evaluation of aloesin." Regulatory Toxicology and Pharmacology 61, no. 2 (2011): 161–71. http://dx.doi.org/10.1016/j.yrtph.2011.07.005.

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12

Simeonova, Petia P. "Evaluation of carbon nanotube toxicity." Nanomedicine: Nanotechnology, Biology and Medicine 2, no. 4 (2006): 304–5. http://dx.doi.org/10.1016/j.nano.2006.10.114.

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13

Vergnes, Jane S., Reinhard Jung, Ajit K. Thakur, Thomas R. Barfknecht, and Vincent L. Reynolds. "Genetic toxicity evaluation of octamethylcyclotetrasiloxane." Environmental and Molecular Mutagenesis 36, no. 1 (2000): 13–21. http://dx.doi.org/10.1002/1098-2280(2000)36:1<13::aid-em3>3.0.co;2-z.

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14

Aylagas, Eva, Iratxe Menchaca, Aitor Laza-Martínez, Sergio Seoane, and Javier Franco. "Evaluation of marine phytoplankton toxicity by application of marine invertebrate bioassays." Scientia Marina 78, no. 2 (2014): 173–83. http://dx.doi.org/10.3989/scimar.03957.26c.

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15

Vanitha Ramesh, G., Jeniben Jyotinra Bhaya, and Siddharth Birla. "Evaluation of Developmental Toxicity of Various Food Preservatives Using Drosophila Melanogaster." International Journal of Science and Research (IJSR) 9, no. 6 (2020): 27–34. http://dx.doi.org/10.21275/sr20524221955.

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16

Yuanita, Emmy, Harno Dwi Pranowo, Dwi Siswanta, et al. "One-Pot Synthesis, Antioxidant Activity and Toxicity Evaluation of Some Hydroxyxanthones." Chemistry & Chemical Technology 12, no. 3 (2018): 290–95. http://dx.doi.org/10.23939/chcht12.03.290.

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17

Clemedson, Cecilia, Elisabeth McFarlane-Abdulla, Marianne Andersson, et al. "MEIC Evaluation of Acute Systemic Toxicity." Alternatives to Laboratory Animals 24, no. 1_part_1 (1996): 251–72. http://dx.doi.org/10.1177/026119299602400102.1.

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The multicentre evaluation of in vitro cytotoxicity (MEIC) study is a programme designed to evaluate the relevance of in vitro toxicity tests for predicting human toxicity, and is organised by the Scandinavian Society for Cell Toxicology. The project started in 1989 and is scheduled to be finished by June 1996. MEIC is a voluntary effort by international laboratories to test the same 50 reference chemicals in their own in vitro toxicity systems. At present, 31 laboratories have submitted results for the first 30 reference chemicals from a total of 68 in vitro cytotoxicity tests. In the definit

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18

Makarova, Veronika, and Konstantin Usov. "EVALUATION OF ACUTE TOXICITY OF ISOPROPYLMETACARBORANE." Modern Technologies and Scientific and Technological Progress 2020, no. 1 (2020): 250–51. http://dx.doi.org/10.36629/2686-9896-2020-1-250-251.

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19

Bertoletti, E., R. P. A. Araújo, P. A. Zagatto, and E. Gherardi-Goldstein. "Toxicity Evaluation of Paper Mill Effluents." Water Science and Technology 20, no. 2 (1988): 191. http://dx.doi.org/10.2166/wst.1988.0068.

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20

Zagorc-Koncan, J., and M. Dular. "Evaluation of Toxicity in Receiving Streams." Water Science and Technology 26, no. 9-11 (1992): 2357–60. http://dx.doi.org/10.2166/wst.1992.0736.

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A laboratory river model for the study of self-purification inhibition in a stream containing toxic substances is presented. It enables an engineering - technological prediction of the impact of toxic substances or wastewaters on dissolved oxygen (DO) profile in an organically polluted river downstream from the point of entry of toxic effluent thus providing rapidly and inexpensively significant design information to an environmental scientist or engineer. The method was applied to the toxicity evaluation of wastewaters from electroplating industry. The effects of copper, cyanide (representing

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21

Wagner, Burkhard O. "Chemical databank and evaluation of toxicity." Information Services & Use 10, no. 1-2 (1990): 101–5. http://dx.doi.org/10.3233/isu-1990-101-213.

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22

Moles, Adam. "Changing Perspectives on Oil Toxicity Evaluation." International Oil Spill Conference Proceedings 2001, no. 1 (2001): 435–39. http://dx.doi.org/10.7901/2169-3358-2001-1-435.

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ABSTRACT Recent advances in oil toxicity research may well alter the way oil spill response decisions are made. Those responding to spills should be aware of the limitations surrounding the use of acute toxicity data to predict even short-term oil effects. Many animals previously classified as tolerant of short-term oil exposure, such as fish eggs and benthic organisms, are just as or much more sensitive than pelagic fishes to chronic exposures. Toxicity bioassays proved to be of limited value in predicting the long-term damage from the Exxon Valdez oil spill because such toxicity information

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23

Clemedson, Cecilia, Elisabeth McFarlane-Abdulla, Marianne Andersson, et al. "MEIC Evaluation of Acute Systemic Toxicity." Alternatives to Laboratory Animals 24, no. 1_part_1 (1996): 273–311. http://dx.doi.org/10.1177/026119299602400103.1.

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Results from tests of the first 30 MEIC reference chemicals in 68 different toxicity assays are presented as a prerequisite to subsequent in vitro/in vivo comparisons of acute toxicity data. A comparative cytotoxicity study was also carried out. Firstly, the variability of all of the results was analysed by using principal components analysis (PCA), analyses of variance (ANOVAs) and pairwise comparisons of means according to Tukey's method. The first PCA component described 80% of the variance of all of the cytotoxicity data. Tukey's ANOVA indicated a similar sensitivity for the assays, of app

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24

Clemedson, Cecilia, Frank A. Barile, Barbro Ekwall, et al. "MEIC Evaluation of Acute Systemic Toxicity." Alternatives to Laboratory Animals 26, no. 1_suppl (1998): 93–129. http://dx.doi.org/10.1177/026119299802601s02.

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Results from tests on the first 30 MEIC reference chemicals in 16 different systems are presented as a prerequisite to the subsequent in vitro/in vivo comparisons of acute toxicity data, i.e. the final MEIC evaluation of all test results of the study. The study is a supplement to the previously published results from 68 methods (including methods 45B and 46B [old numbers]) used to test the same set of chemicals. The strategies and methods of the preceding paper were employed to enable a comparative cytotoxicity analysis of the results from these 68 methods and from the 16 new methods to be mad

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25

Clemedson, Cecilia, Marianne Andersson, Yasunobu Aoki, et al. "MEIC Evaluation of Acute Systemic Toxicity." Alternatives to Laboratory Animals 26, no. 1_suppl (1998): 131–83. http://dx.doi.org/10.1177/026119299802601s03.

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Results from tests on the Multicentre Evaluation of In Vitro Cytotoxicity (MEIC) reference chemicals 31–50 in 67 different in vitro toxicity assays are presented in this paper as a prerequisite to in vitro/in vivo comparisons for all MEIC in vitro toxicity data in forthcoming papers, i.e. the final MEIC evaluation of the relevance of the tests. With the aim of increasing knowledge about the relative significance of some in vitro methodological factors, the strategies and methods of the preceding parts in the MEIC series (Parts II and III) were again employed to enable comparative cytotoxicity

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26

Ekwall, Björn, Cecilia Clemedson, Balcarras Crafoord, et al. "MEIC Evaluation of Acute Systemic Toxicity." Alternatives to Laboratory Animals 26, no. 2_suppl (1998): 571–616. http://dx.doi.org/10.1177/026119299802602s02.

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The Multicenter Evaluation of In Vitro Cytotoxicity (MEIC) programme was set up to evaluate the relevance for acute human systemic toxicity of in vitro cytotoxicity tests. At the end of the programme in the summer of 1996, 29 laboratories had tested all 50 reference chemicals in 61 cytotoxicity assays. As a necessary prerequisite to the forthcoming evaluation papers of this series, this paper presents the animal and human toxicity data of the programme. This database contains tabulated handbook data for the 50 chemicals, on: a) oral rat and mouse LD50 values; b) acute oral lethal doses in huma

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27

Ekwall, Björn, Frank A. Barile, Argelia Castano, et al. "MEIC Evaluation of Acute Systemic Toxicity." Alternatives to Laboratory Animals 26, no. 2_suppl (1998): 617–58. http://dx.doi.org/10.1177/026119299802602s03.

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The Multicenter Evaluation of In Vitro Cytotoxicity (MEIC) programme was set up to evaluate the relevance for human acute toxicity of in vitro cytotoxicity tests. At the end of the project in 1996, 29 laboratories had tested all 50 reference chemicals in 61 cytotoxicity assays. Five previous articles have presented the in vitro data and the human database to be used in the evaluation. This article presents three important parts of the final evaluation: a) a comparison of rat and mouse oral LD50 with human acute lethal doses for all 50 chemicals; b) a display of the correlations between IC50 (c

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28

Reddy, Gunda, Dale A. Mayhew, and Anne E. G. Hampton. "Acute Toxicity Evaluation of Diesel Fuel." Journal of the American College of Toxicology 15, no. 1_suppl (1996): S5—S6. http://dx.doi.org/10.1177/10915818960150s103.

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29

Reddy, Gunda, Dale A. Mayhew, and Anne E. G. Hampton. "Acute Toxicity Evaluation of Fog Oil." Journal of the American College of Toxicology 15, no. 1_suppl (1996): S7—S8. http://dx.doi.org/10.1177/10915818960150s104.

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30

Reddy, Gunda, Indu A. Muni, Elliot B. Gordon, Jane B. Goodband, Dale A. Mayhew, and Howard T. Bausum. "Acute Toxicity Evaluation of Brass Powder." Journal of the American College of Toxicology 15, no. 1_suppl (1996): S12—S14. http://dx.doi.org/10.1177/10915818960150s106.

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31

Hendrich, Suzanne, Maohong Fan, Shih wu Sung, et al. "Toxicity evaluation of polymeric ferric sulphate." International Journal of Environmental Technology and Management 1, no. 4 (2001): 464. http://dx.doi.org/10.1504/ijetm.2001.000775.

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32

Gruiz, Katalin, Ildikó Fekete-Kertész, Zsuzsanna Kunglné-Nagy, et al. "Direct toxicity assessment — Methods, evaluation, interpretation." Science of The Total Environment 563-564 (September 2016): 803–12. http://dx.doi.org/10.1016/j.scitotenv.2016.01.007.

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33

Baer, Kevin N., Robert L. Boeri, Timothy J. Ward, and David W. Dixon. "Aquatic toxicity evaluation of para-methylstyrene." Ecotoxicology and Environmental Safety 53, no. 3 (2002): 432–38. http://dx.doi.org/10.1016/s0147-6513(02)00035-0.

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34

Parus, Anna, Marta Woźniak, Mateusz Sydow, Alicja Szulc, Lukasz Chrzanowski, and Grzegorz Framski. "Evaluation of toxicity of glucose surfactants." New Biotechnology 33 (July 2016): S132. http://dx.doi.org/10.1016/j.nbt.2016.06.1182.

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35

Beaudoin, Allan R. "A developmental toxicity evaluation of gossypol." Contraception 37, no. 2 (1988): 197–219. http://dx.doi.org/10.1016/0010-7824(88)90131-x.

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36

Robertson, Donald G. "Muscling Mussels: Metabolomic Evaluation of Toxicity." Toxicological Sciences 115, no. 2 (2010): 305–6. http://dx.doi.org/10.1093/toxsci/kfq088.

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37

DEY, B. P., and M. L. FIELDS. "TOXICITY EVALUATION OF STRAINS OF CELLULOMONAS." Journal of Food Safety 15, no. 3 (1995): 265–73. http://dx.doi.org/10.1111/j.1745-4565.1995.tb00138.x.

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38

Reyes-Contreras, Carolina, and Gladys Vidal. "Methanogenic toxicity evaluation of chlortetracycline hydrochloride." Electronic Journal of Biotechnology 18, no. 6 (2015): 445–50. http://dx.doi.org/10.1016/j.ejbt.2015.09.009.

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39

Wells, M. J. M., A. J. Rossano, and E. C. Roberts. "Textile wastewater effluent toxicity identification evaluation." Archives of Environmental Contamination and Toxicology 27, no. 4 (1994): 555–60. http://dx.doi.org/10.1007/bf00214849.

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40

Grant, Roberta L., Bernard J. Kadlubar, Neeraja K. Erraguntla, and Michael Honeycutt. "Evaluation of acute inhalation toxicity for chemicals with limited toxicity information." Regulatory Toxicology and Pharmacology 47, no. 3 (2007): 261–73. http://dx.doi.org/10.1016/j.yrtph.2006.11.003.

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41

Gustavson, K. E., S. A. Sonsthagen, R. A. Crunkilton, and J. M. Harkin. "Groundwater toxicity assessment using bioassay, chemical, and toxicity identification evaluation analyses." Environmental Toxicology 15, no. 5 (2000): 421–30. http://dx.doi.org/10.1002/1522-7278(2000)15:5<421::aid-tox10>3.0.co;2-z.

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42

Lin, Cheng-Fang, Oliver J. Hao, and Fu-Tien Jeng. "Microtox evaluation of industrial wastewaters." Water Science and Technology 30, no. 10 (1994): 97–106. http://dx.doi.org/10.2166/wst.1994.0516.

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The main purpose of this study was to establish an inhibitory database using the Microtox assay for different wastes. The waste samples included 19 pretreated industrial wastes from two different industrial parks, 11 other industrial wastes outside industrial parks, and different treatment process effluents. The following is a brief summary of the findings from this study: (1) COD and BOD had a close relationship among different wastes; (2) Microtox data did not correlate with the conventional parameters of BOD, COD and SS; (3) many wastes did not meet the pretreatment standards and exhibited

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43

Tišler, T., and J. Zagorc-Koncan. "The toxicity evaluation of wastewater from the chemical industry." Water Science and Technology 30, no. 10 (1994): 107–11. http://dx.doi.org/10.2166/wst.1994.0517.

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The purpose of our investigation was the acute and chronic toxicity evaluation of the wastewater from the chemical industry, while the previous study had indicated high toxicity of the receiving streams far away from the point of wastewater inflow. The luminescent bacteria Photobacterium phosphoreum and invertebrate Daphnia magna were used for toxicity tests. The results of the toxicity tests showed that the investigated wastewater contained toxic substances, which caused acute and chronic toxicity to test organisms. Daphnia magna were more sensitive than Photobacterium phosphoreum. The acute

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44

Kadam, Asha Bhausaheb. "Evaluation of Synergistic Formulation Extract of Traditional Contraceptive Plants for Acute Oral Toxicity." Advances in Clinical Toxicology 8, no. 4 (2023): 1–8. http://dx.doi.org/10.23880/act-16000284.

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In folk medicine, certain plants are used to prevent pregnancy. The purpose of the study was to evaluate the synergistic formulation of conventional contraceptive herb’s acute toxicity. Acute toxicity refers to a negative change that happens right away after exposure to a drug. Using OECD-423 recommendations, the acute toxicity of crude oil and its aqueous extract was assessed after oral administration to female mice. 2000mg/kg of a high extract was provided as a single dosage, and the effects on mortality, behavioural pattern, and spontaneous movement (Locomotor activity) of the body were ass

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45

Kabadi, Shruti V., Jeffrey Fisher, Benjamin Hung, and Jason Aungst. "Considerations for Applying Route-to-Route Extrapolation to Assess the Safety of Oral Exposure to Substances." Biomolecules 13, no. 1 (2022): 5. http://dx.doi.org/10.3390/biom13010005.

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The safety evaluation of oral exposure to substances, such as food ingredients, additives, and their constituents, relies primarily on a careful evaluation and analysis of data from oral toxicity studies. When relevant oral toxicity studies are unavailable or may have significant data gaps that make them inadequate for use in safety evaluations, data from non-oral toxicity studies in animals, such as studies on inhalation, dermal exposure, etc., might be used in support of or in place of oral toxicity studies through route-to-route (R-t-R) extrapolation. R-t-R extrapolation is applied on a cas

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46

Choi, Seo Yoon, Tae Hee Kim, Min Jeong Kim, et al. "Validating Well-Functioning Hepatic Organoids for Toxicity Evaluation." Toxics 12, no. 5 (2024): 371. http://dx.doi.org/10.3390/toxics12050371.

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“Organoids”, three-dimensional self-organized organ-like miniature tissues, are proposed as intermediary models that bridge the gap between animal and human studies in drug development. Despite recent advancements in organoid model development, studies on toxicity using these models are limited. Therefore, in this study, we aimed to analyze the functionality and gene expression of pre- and post-differentiated human hepatic organoids derived from induced pluripotent stem cells and utilize them for toxicity assessment. First, we confirmed the functional similarity of this hepatic organoid model

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47

Lee, Sijoon, Kyung-Ku Kang, Soo-Eun Sung, et al. "Toxicity Study and Quantitative Evaluation of Polyethylene Microplastics in ICR Mice." Polymers 14, no. 3 (2022): 402. http://dx.doi.org/10.3390/polym14030402.

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The production, use, and waste of plastics increased worldwide, which resulted in environmental pollution and a growing public health problem. In particular, microplastics have the potential to accumulate in humans and mammals through the food chain. However, the toxicity of microplastics is not well understood. In this study, we investigated the toxicity of 10–50 μm polyethylene microplastics following single- and 28-day repeated oral administration (three different doses of microplastics of 500, 1000, and 2000 mg/kg/day) in ICR mice. For the investigation, we administered the microplastics o

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48

Riabenko, T. V., V. I. Hula, O. V. Korenkov, et al. "METOTREKSATIN TOKSİK TƏSİRLƏRİNİN TƏDQİQİ." Azerbaijan Medical Journal, no. 4 (December 20, 2023): 141–46. http://dx.doi.org/10.34921/amj.2023.4.020.

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The article analyzes literary sources on the study of the toxic effects of methotrexate in the treatment of various diseases and examines scientific data on methods of preventing their development. According to the literary information, the main toxic effects of methotrexate manifest as damage to the liver, kidneys, bone marrow, lungs, digestive system, and skin. Methotrexate exhibits pronounced embryotoxic and teratogenic effects. Monitoring of blood test parameters and selection of an optimal dose will minimize methotrexate toxic effects and help in achieving success in the treatment. Məqalə

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49

Daflon, S. D. A., I. L. Guerra, M. V. Reynier, C. M. R. Botta, and J. C. Campos. "Toxicity identification and evaluation of a refinery wastewater from Brazil (Phase I)." Ecotoxicology and Environmental Contamination 10, no. 1 (2015): 41. http://dx.doi.org/10.5132/eec.2015.01.07.

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50

Syamaroopa Jnanathapaswini, Janani. "FTIR & Acute, Subacte Toxicity Evaluation of Alli Chooranam (Nympheanouchali) burm. f)." International Journal of Science and Research (IJSR) 12, no. 3 (2023): 904–10. http://dx.doi.org/10.21275/sr23315122424.

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