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Journal articles on the topic 'Toxicity profile'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Wells, J. Elisabeth, Nick B. Cross, and Ann K. Richardson. "Toxicity profile of lithium." Lancet 379, no. 9834 (2012): 2338. http://dx.doi.org/10.1016/s0140-6736(12)61012-5.

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Sharwan, Gotmi, Parag Jain, Ravindra Pandey, and Shiv Shankar Shukla. "Toxicity profile of traditional herbal medicine." Journal of Ayurvedic and Herbal Medicine 1, no. 3 (2015): 81–90. http://dx.doi.org/10.31254/jahm.2015.1306.

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Medicines obtained from natural sources have become the basis for pharmaceutical drugs. Traditional herbal medicines are naturally occurring plant derived substances; these have been used for treatment and cure of various diseases and as a nutraceuticals. Toxicological research and testing help to live safely and predict benefit from synthetic and natural substance while avoiding harm. The toxicity study is done for data profiling and safety of the herbal drugs, the toxicity study of various plant and herbal formulation are reported. This review briefly discusses the need of toxicity study, to

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3

Meneghelli, I., C. Biagi, M. L. Iorio, et al. "Toxicity Profile of Ticlopidine: Unavoidable Reactions?" Drug Safety 30, no. 10 (2007): 919–90. http://dx.doi.org/10.2165/00002018-200730100-00091.

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4

Lucero, María Luisa, Joseba K. Arteche, E. W. Sommer, and Agustín Casadesus. "Preclinical toxicity profile of oral bilastine." Drug and Chemical Toxicology 35, sup1 (2012): 25–33. http://dx.doi.org/10.3109/01480545.2012.682652.

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5

MUTO, Shin-ichi, Hiroko KASAHARA, Ryohei YOKOI, et al. "Toxicity Profile of Silodosin (KMD-3213)." YAKUGAKU ZASSHI 126, Special (2006): 247–56. http://dx.doi.org/10.1248/yakushi.kj00004483560.

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6

CHARTRAND, STEPHEN A. "Safety and toxicity profile of aztreonam." Pediatric Infectious Disease Journal 8, no. 9 (1989): S120–123. http://dx.doi.org/10.1097/00006454-198909001-00007.

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7

MUTO, Shin-ichi, Hiroko KASAHARA, Ryohei YOKOI, et al. "Toxicity Profile of Silodosin (KMD-3213)." YAKUGAKU ZASSHI 126, Special_Issue (2006): 247–56. http://dx.doi.org/10.1248/yakushi.126.247.

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8

WORCESTER, SHARON. "Meta-Analysis Outlines Lithium Toxicity Profile." Clinical Psychiatry News 40, no. 2 (2012): 6. http://dx.doi.org/10.1016/s0270-6644(12)70035-8.

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9

WORCESTER, SHARON. "Meta-Analysis Outlines Lithium Toxicity Profile." Family Practice News 42, no. 2 (2012): 33. http://dx.doi.org/10.1016/s0300-7073(12)70097-x.

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10

Solomon, Benjamin. "Refining the Toxicity Profile of Crizotinib." Journal of Thoracic Oncology 9, no. 11 (2014): 1596–97. http://dx.doi.org/10.1097/jto.0000000000000375.

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11

Khraishi, Mm, and G. Singh. "The role of anti-malarials in rheumatoid arthritis – the American experience." Lupus 5, no. 1_suppl (1996): 41–44. http://dx.doi.org/10.1177/0961203396005001101.

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Rheumatoid Arthritis (RA) is a chronic disease with significant morbidity and functional disability. The traditional treatment for RA relied on the use of NSAIDs early in the disease course, followed by disease-modifying agents later. More recently, the disease-modifying anti-rheumatic drugs (DMARDs) have become the mainstay of RA therapy because of the recognition of their superior efficacy/toxicity profile. The antimalarial drugs, chloroquine and hydroxychloroquine, are some of the most commonly used DMARDs in the management of RA. They have been shown to be significantly more effective than

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12

&NA;. "A profile of nitrofurantoin toxicity and efficacy." Reactions Weekly &NA;, no. 291 (1990): 4–5. http://dx.doi.org/10.2165/00128415-199002910-00006.

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13

KHOKHLOVA, S. V., and O. A. SHILKINA. "PARP INHIBITORS IN OVARIAN CANCER: TOXICITY PROFILE." Medical Council, no. 6 (January 1, 2017): 24–29. http://dx.doi.org/10.21518/2079-701x-2017-6-24-29.

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14

Jos, Angeles, and Ana M. Cameán. "Freshwater Algal Toxins: Monitoring and Toxicity Profile." Toxins 12, no. 10 (2020): 653. http://dx.doi.org/10.3390/toxins12100653.

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15

Ballestín, Pablo, Alfonso López de Sá, Cristina Díaz-Tejeiro, et al. "Understanding the Toxicity Profile of Approved ADCs." Pharmaceutics 17, no. 2 (2025): 258. https://doi.org/10.3390/pharmaceutics17020258.

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Background: Antibody–drug conjugates (ADCs) represent a novel therapeutic class that combines an antibody against a tumor-associated antigen (TAA), a payload, and a linker that binds these two components. Serious adverse events (SAEs), particularly those of grade 3 (G3) or higher, frequently contribute to the abandonment of ADCs during clinical development. Methods: In this study, we analyzed the toxicity profiles of all approved ADCs, aiming to uncover correlations between their safety profiles and the specific characteristics of their components. Results: In our analysis, dose reductions, do

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16

Sethi, Poonam, and Pushpa R. Kulkarni. "Leucaena Leucocephala a Nutrition Profile." Food and Nutrition Bulletin 16, no. 3 (1995): 1–16. http://dx.doi.org/10.1177/156482659501600307.

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Leucaena leucocephala is one of the fastest-growing leguminous trees. Its foliage is used as animal feed, and its leaves and seeds are used as human food in Central America, Indonesia, and Thailand. Mimosine, the toxic, non-protein amino acid in Leucaena, causes alopecia, growth retardation, cataract, goitre, decreased fertility, and mortality in non-ruminants. The mechanism of this toxicity is complicated. Mimosine probably exerts its toxic action by blocking the metabolic pathways of aromatic amino acids and tryptophan; by chelating metals; by antagonizing the action of vitamin B6; by inhibi

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17

Padgett, SL, JE Stokes, RL Tucker, and LG Wheaton. "Hematometra secondary to anticoagulant rodenticide toxicity." Journal of the American Animal Hospital Association 34, no. 5 (1998): 437–39. http://dx.doi.org/10.5326/15473317-34-5-437.

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An adult, intact female Australian shepherd presented for frank vaginal bleeding of unknown duration. The only coagulation profile abnormality upon presentation was mild prolongation of the partial thromboplastin time (PTT). The uterus was removed at surgery and contained a large amount of coagulated blood. Clotting profiles were markedly abnormal 48 hours postoperatively. Serum analysis was positive for brodifacoum, an anticoagulant rodenticide. Preoperative coagulation was most likely normalized by vitamin K1 therapy administered prior to presentation. The only manifestation of anticoagulant

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18

Tate, Pravin M., B. J. Patgiri, P. K. Prajapati, and B. Ravishankar. "Safety profile of Naga Bhasma prepared by two classical methods." AYU (An International Quarterly Journal of Research in Ayurveda) 45, no. 2 (2024): 96–110. http://dx.doi.org/10.4103/ayu.ayu_87_20.

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Abstract Background: Naga Bhasma (NB) (incinerated lead) has been indicated as a remedy for the treatment of a wide range of diseases including Prameha (diabetes), Kasa (cough), Raktapradara (menorrhagia), Shukradosha (defects in semen), etc., However, improperly prepared NB can cause harmful effects on the human body. In modern science also, lead consumption has been accepted to produce toxicity. Aim: The present study was undertaken to elucidate and compare the toxicity profile of two samples of NB prepared by two different methods to ascertain the safety aspects. Materials and methods: In t

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19

Joshi, Padmaja V., Atul A. Shirkhedkar, Krishnan Prakash, and Vijay L. Maheshwari. "Antidiarrheal activity, chemical and toxicity profile ofBerberis aristata." Pharmaceutical Biology 49, no. 1 (2010): 94–100. http://dx.doi.org/10.3109/13880209.2010.500295.

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20

Erickson, Britt E. "Research Profile: Proteomics sheds light on dioxin toxicity." Journal of Proteome Research 4, no. 4 (2005): 1049. http://dx.doi.org/10.1021/pr0505190.

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21

Kharlamova, Ulyana V., Andrei V. Vazhenin, Olga V. Kurchenkova, Alina A. Brosalina, and Ksenia N. Troyan. "Cardiovascular toxicity profile of immune response checkpoint inhibitors." Clinical review for general practice 5, no. 7 (2024): 18–22. http://dx.doi.org/10.47407/kr2024.5.7.00444.

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The introduction of immune response checkpoint inhibitors is a step toward an innovative treatment paradigm, but along with increased antitumor efficacy may come a potential increase in cardiotoxicity. Objective. To study the frequency of clinical manifestations of early cardiovascular toxicity during IcT administration in patients with malignant neoplasms. Materials and methods. 47 patients (27 men, 20 women), mean age 59,5±7,38 years were included in the prospective study. clinical cardiovascular symptoms, dynamics of blood pressure, laboratory parameters (c-reactive protein (crP), troponin

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22

Shale, K., J. Mukamugema, R. J. Lues, and P. Venter. "Toxicity profile of commercially produced indigenous banana beer." Food Additives & Contaminants: Part A 29, no. 8 (2012): 1300–1306. http://dx.doi.org/10.1080/19440049.2012.688879.

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23

Darcy, Philip, Keith Dredge, Padraig Kellehir, John P. Kelly, Brian E. Leonard, and Philip L. Chambers. "Acute Toxicity Profile of Maprotiline in the Rat." Pharmacology & Toxicology 85 (October 1999): 276–81. http://dx.doi.org/10.1111/j.1600-0773.1999.tb02022.x.

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24

Krenzelok, Edward P. "Liquid automatic dishwashing detergents: A profile of toxicity." Annals of Emergency Medicine 18, no. 1 (1989): 60–63. http://dx.doi.org/10.1016/s0196-0644(89)80315-4.

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25

Young, J. "Mecamylamine: new therapeutic uses and toxicity/risk profile." Clinical Therapeutics 23, no. 4 (2001): 532–65. http://dx.doi.org/10.1016/s0149-2918(01)80059-x.

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26

Ali, Mujtaba. "Clinical profile of paraphenylenediamine intoxication." Rawal Medical Journal 49, no. 1 (2024): 185. http://dx.doi.org/10.5455/rmj.20231126082530.

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Hair dyes are widely used for decorative skin paint, nail coloring, and hair dye. Hair dye toxicity has been attributed to adding a synthetic dye paraphenylenediamine (PPD). PPD is added to natural henna to accentuate the dark color and shorten the duration of application. PPD self-harm or accidental toxicity is well-known in developing countries and extensively reported in the medical literature. Acute intoxication with PPD causes characteristic severe angioedema of the pharynx and larynx which usually necessitates tracheostomy, and it is associated with facial and tongue edema. PPD poisoning

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27

Oluwasegun, Adedokun, Ume Ogochukwu, Odunola Mansurat, et al. "Evaluation of toxicological profile of methanol leaf extract of Waltheria indica (Sterculiaceae)." GSC Biological and Pharmaceutical Sciences 17, no. 2 (2021): 034–43. https://doi.org/10.5281/zenodo.5720153.

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<em>Waltheria indica</em> has been claimed to be used in managing several diseases in traditional medicine, although substantial scientific data are not available as regards its safety despite its pronounced efficacy in management of some ailments. Therefore, methanol leaf extract of <em>W. indica </em>was evaluated for its effects on some toxicological parameters using experimental animals. However, acute and sub-acute toxicity were carried out using experimental animals as described by standard methods. Absence of death reported after 24 hours of single oral administration of&

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28

Benrahou, Kaoutar, Hanae Naceiri Mrabti, Hamza M. Assaggaf, et al. "Acute and Subacute Toxicity Studies of Erodium guttatum Extracts by Oral Administration in Rodents." Toxins 14, no. 11 (2022): 735. http://dx.doi.org/10.3390/toxins14110735.

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The present study aimed to evaluate the acute and subacute toxicity profiles of Erodium guttatum extracts in mice using the methods described in the guidelines of the OECD. In the acute toxicity study, the LD50 value was greater than 2000 mg/kg. The subacute toxicity study of E. guttatum extracts showed no significant changes in body or organ weights. The administration of E. guttatum extracts to mice at a dose of 200 mg/kg led to an increase in white blood cells, platelets and hemoglobin. Moreover, the aqueous extract of E. guttatum only decreased liver aspartate aminotransferase (ASAT) level

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29

Georgewill, Udeme Owunari, and Janet Chika Iwu. "Acute toxicity profile of chlorpheniramine: Potential use as antidote to dichlorvos poisoning." GSC Biological and Pharmaceutical Sciences 14, no. 1 (2021): 149–53. https://doi.org/10.5281/zenodo.4527721.

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<strong>Introduction</strong>: Pesticide poisoning is a serious public health concern all over the world. Alternative therapies for organophosphorus poisoning are being explored, and this could be very useful especially in emergency situations of antidote shortages. This study therefore set out to determine the effects of chlorpheniramine on the kidney and liver function in dichlorvos poisoning. <strong>Methodology</strong>: Chlorpheniramine (2mg/kg, 4mg/kg, and 8mg/kg), atropine (0.4mg/kg, 0.8mg/kg, and 1.6mg/kg) and dichlorvos (4mg/kg) were all administered intraperitoneally. Administration

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30

Smith, Mary Lou, Carol B. White, Elda Railey, Anna Maria Storniolo, and George W. Sledge. "Examining patient choices for metastatic breast cancer drugs." Journal of Clinical Oncology 30, no. 15_suppl (2012): 6053. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.6053.

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6053 Background: Patients with metastatic breast cancer face difficult drug decisions. Our previous research (ASCO Proc 2011, abstr 6044) focused on general benefit and toxicity showed that conjoint analysis (CA) allows patients to express preferences; our current research quantifies patient preference for specific drug profiles (capecitabine and paclitaxel). Methods: Research Advocacy Network and CBWhite conducted research using CA for DOD Center of Excellence for Individualization of Therapy in Breast Cancer. An online survey was sent by four breast cancer organizations (N=641). Questions el

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31

Lai, Yu-Wei, Yi-Nan Lee, Hung-I. Yeh та ін. "Long-Term Safety Evaluation of Fluorescent Gold Nanoclusters Conjugated with α-Lipoic Acid: Insights from a Six-Month In Vivo Study". Journal of Functional Biomaterials 16, № 3 (2025): 89. https://doi.org/10.3390/jfb16030089.

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Background: Fluorescent gold nanoclusters conjugated with α-lipoic acid (FANCs) have shown great promise for drug development. In a previous study, FANCs did not show any acute or subacute toxicity under 0.6–20 μM/100 μL/25 g body weight in male and female ICR mice. However, the chronic toxicity of FANCs has not been studied. Aim of study: This study used oral administration of FANCs to determine the long-term safety profile and adverse effects in ICR mice. Methods: In vivo chronic toxicity was examined via oral administration of FANCs to male and female ICR mice. The daily food consumption, b

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32

Garg, Praveen, Fauzia Rana, Ruchi Gupta, Elena M. Buzaianu, and Troy H. Guthrie. "Predictors of Toxicity and Toxicity Profile of Adjuvant Chemotherapy in Elderly Breast Cancer Patients." Breast Journal 15, no. 4 (2009): 404–8. http://dx.doi.org/10.1111/j.1524-4741.2009.00745.x.

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33

R., Dawnji S., Reeja R., and Rakesh Praveen Raj M. R. "Toxicity profile of thal-dex regime in patients with multiple myeloma." International Journal of Basic & Clinical Pharmacology 6, no. 5 (2017): 1073. http://dx.doi.org/10.18203/2319-2003.ijbcp20171505.

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Background: To study the spectrum, incidence and severity of toxicity among Multiple Myeloma patients receiving Thal-Dex in South Indian population.Methods: Between November 2005 and November 2005, 25 adult patients with previously- untreated Multiple Myeloma were assigned to receive Thal-Dex at Regional Cancer Centre, Trivandrum. During chemotherapy, patients were followed-up to detect the development of any toxicity symptoms. The toxicities recorded, were graded according to the criteria of the World Health Organization toxicity-guidelines.Results: In the 25 patients who received Thal-Dex, p

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34

Murwanti, Retno, A. Nurrochmad, Andayana P. Gani, et al. "Acute and Subchronic Oral Toxicity Evaluation of Herbal Formulation: Piper crocatum Ruiz and Pav., Typhonium flagelliforme (Lodd.) Blume, and Phyllanthus niruri L. in Sprague–Dawley Rats." Journal of Toxicology 2023 (January 3, 2023): 1–11. http://dx.doi.org/10.1155/2023/7511397.

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Background. The product combination of Piper crocatum Ruiz. and Pav., Phyllanthus niruri Linn., and Typhonium flagelliforme (Lodd.) BL ethanolic extract (SKM) exerts immunomodulatory activity. However, the toxicity profile of the combination has never been investigated. Objective. This study aimed to establish the acute toxicity profile of the SKM product on Sprague–Dawley (SD) rats and its subchronic toxicity profile on female SD rats. Method. The acute and subchronic toxicity tests were conducted in accordance with OECD 423 and OECD 408, respectively. Result. The SKM product was safe up to 5

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35

Sundaram, Dhivya, Sobiya Mathiayalagan, Palanisamy Selvamani, and Subbiah Latha. "Cadaba indica Leaf Extract: Neuroprotection and Cognitive Enhancement with Safety Profile Comparison." International Journal of Nutrition, Pharmacology, Neurological Diseases 13, no. 4 (2023): 259–71. http://dx.doi.org/10.4103/ijnpnd.ijnpnd_6_22.

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Aim: The current study aims to investigate the toxicity profile, the anti-amyloidogenic, and anti-ameliorative effects of crude ethanol extract from Cadaba indica leaves in contrast with a prominent drug. Methods: Phytochemical screening of the ethanol extract of C. indica was performed by GC–MS analysis. The cell viability of SH-SY5Y cells was assessed by a neutral red uptake assay, and neuroprotective effects were evaluated against the Aβ25–35 toxicity in SH-SY5Y cells experienced pretreatment with plant extracts. In acute and sub-chronic toxicity studies were conducted according to the OECD

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36

Chen, Huanxian, Judy Y. W. Chan, Xue Yang, et al. "Developmental and organ-specific toxicity of cucurbit[7]uril: in vivo study on zebrafish models." RSC Advances 5, no. 38 (2015): 30067–74. http://dx.doi.org/10.1039/c5ra04335b.

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37

Matos, Renata Almeida de, Érica Toledo de Mendonça, Patrícia De Oliveira Salgado, and Cristiane Chaves de Souza. "Profile of patients with hematological toxicity grades 3 and 4 and gastrointestinal toxicity of patients undergoing chemotherapy." Ciência e Natura 43 (May 18, 2021): e17-43673. http://dx.doi.org/10.5902/2179460x43673.

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The administration of chemotherapeutic agents may lead to the occurrence of toxicities in organic systems not affected by cancer. This study aimed to evaluate the profile of patients with hematological toxicity grades 3 and 4 and gastrointestinal toxicity of patients undergoing chemotherapy. There was a prevalence of 48.70% of gastrointestinal toxicity, 42.20% of hematological toxicity and 9.10% of hematological and gastrointestinal toxicities. The most common symptoms of toxicity grade 3 was Hb 8.0 - 6,5g/dl (47.05%), and of hematological toxicity grade 4 was febrile neutropenia (44.44%). Pat

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38

Prayogo, Yanico Hadi, Wasrin Syafii, Rita Kartika Sari, Irmanida Batubara, and Danu. "Pharmacological Activity and Phytochemical Profile of Acacia Heartwood Extracts." Scientia Pharmaceutica 89, no. 3 (2021): 37. http://dx.doi.org/10.3390/scipharm89030037.

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Reactive oxygen species (ROS) are related to several degenerative diseases. In this study, Acacia, a genus with many fast-growing species, was investigated to explore the many phytochemical compounds that are biologically active in processes dealing with ROS-related diseases. This study aimed to select extracts of Acacia heartwood on the basis of their pharmacological and phytochemical profiles and identify their bioactive compounds. Five methanolic extracts from Acacia heartwood were evaluated for their antioxidant activity using three different in vitro assays: toxicity toward Artemia salina

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39

Markovich, A. A., A. A. Kuznetsova, V. A. Gorbunova, et al. "Potential for use sunitinib in pancreatic neuroendocrine tumors." Medical Council, no. 10 (June 24, 2019): 115–19. http://dx.doi.org/10.21518/2079-701x-2019-10-115-119.

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The treatment efficacy and toxicity profile was evaluated in 33 patients with highly differentiated neuroendocrine tumors NEO (G1, G2), who received sunitinib therapy in various dose regimens. Stable disease was achieved in 24 patients (72.7%), partial effect in 1 patient (3%). The efficacy of treatment did not depend on the used dose regimen. The toxicity profile was consistent with international study data.

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40

Gobran, Nagy Samy, Mohammed Reda Kelany, and Mohammed Abdallah Fathy. "Chemotherapy Toxicity Profile in Adjuvant Treated Colorectal Carcinoma Patients." Journal of Cancer Therapy 11, no. 02 (2020): 74–87. http://dx.doi.org/10.4236/jct.2020.112007.

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41

Thompson, Marcher, and Kenneth E. Rosenzweig. "The evolving toxicity profile of SBRT for lung cancer." Translational Lung Cancer Research 8, no. 1 (2018): 48–57. http://dx.doi.org/10.21037/tlcr.2018.10.06.

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42

Nirmala, M. Joyce, John Thomas, Amitava Mukherjee, and N. Chandrasekaran. "Assessing the Toxicity Profile of Clove Oil Microemulsion System." Journal of Bionanoscience 8, no. 2 (2014): 96–100. http://dx.doi.org/10.1166/jbns.2014.1213.

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43

&NA;. "Dideoxyinosine: promising antiviral effects and toxicity profile in AIDS." Inpharma Weekly &NA;, no. 754 (1990): 7. http://dx.doi.org/10.2165/00128413-199007540-00015.

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44

Smith, Brenda B., Mary Ellen Cosenza, Audrey Mancini, et al. "A Toxicity Profile of Osteoprotegerin in the Cynomolgus Monkey." International Journal of Toxicology 22, no. 5 (2003): 403–12. http://dx.doi.org/10.1177/109158180302200512.

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Osteoprotegerin (OPG) is a novel secreted glycoprotein of the tumor necrosis factor (TNF) receptor superfamily that acts as an antiresorptive agent inhibiting osteoclast maturation. OPG acts by competitively inhibiting the association of the OPG ligand with the RANK receptor on osteoclasts and osteoclast precursors. This inhibition of osteoclasts can lead to excess accumulation of newly synthesized bone and cartilage in vivo. The purpose of this study was to investigate the potential toxicity of a human recombinant form of OPG in the young cynomolgus monkey. OPG was administered by intravenous

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45

Chabane, Sarra, Amel Boudjelal, Morris Keller, Sara Doubakh, and Olivier Potterat. "Teucrium polium - wound healing potential, toxicity and polyphenolic profile." South African Journal of Botany 137 (March 2021): 228–35. http://dx.doi.org/10.1016/j.sajb.2020.10.017.

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46

Edet, Uwem Okon, Ogemdi Chinwendu Anika, and Elizabeth Umoren. "Toxicity Profile of Crude Oil on Degrading Bacterial Isolates." International Journal of Scientific & Engineering Research 10, no. 7 (2019): 1131–35. http://dx.doi.org/10.14299/ijser.2019.07.08.

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47

Sangeetha, M. K., D. Eazhisai Vallabi, Veeresh Kumar Sali, J. Thanka, and Hannah R. Vasanthi. "Sub-acute toxicity profile of a modified resveratrol supplement." Food and Chemical Toxicology 59 (September 2013): 492–500. http://dx.doi.org/10.1016/j.fct.2013.06.037.

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48

Williams, John B., Susan M. Keenan, Qi Gan, and Mark M. Knuepfer. "Hemodynamic response profile predicts susceptibility to cocaine-induced toxicity." European Journal of Pharmacology 464, no. 2-3 (2003): 189–96. http://dx.doi.org/10.1016/s0014-2999(03)01429-8.

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49

McKnight, Rebecca F., Marc Adida, Katie Budge, Sarah Stockton, Guy M. Goodwin, and John R. Geddes. "Lithium toxicity profile: a systematic review and meta-analysis." Lancet 379, no. 9817 (2012): 721–28. http://dx.doi.org/10.1016/s0140-6736(11)61516-x.

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Christian, Mildred S., Valerie A. Sharper, Alan M. Hoberman, et al. "The Toxicity Profile of Hydrolyzed Aqueous Olive Pulp Extract." Drug and Chemical Toxicology 27, no. 4 (2004): 309–30. http://dx.doi.org/10.1081/dct-200039714.

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