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Journal articles on the topic 'Toxicity testing In vitro'

Author: Grafiati

Published: 4 June 2021

Last updated: 30 July 2024

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1

Ciabattoni, G., P. Montuschi, D. Curró, and P. Preziosi. "In vitro testing for lung toxicity." Toxicology in Vitro 7, no. 5 (September 1993): 581–85. http://dx.doi.org/10.1016/0887-2333(93)90091-i.

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2

Flint, Oliver. "In Vitro Toxicity Testing: Redefining our Objectives." Alternatives to Laboratory Animals 20, no. 4 (October 1992): 571–74. http://dx.doi.org/10.1177/026119299202000411.

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3

Soldatow, Valerie Y., Edward L. LeCluyse, Linda G. Griffith, and Ivan Rusyn. "In vitro models for liver toxicity testing." Toxicol. Res. 2, no. 1 (2013): 23–39. http://dx.doi.org/10.1039/c2tx20051a.

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4

Lipman, Jack, Oliver Flint, June Bradlaw, John Frazier, Charlene McQueen, Carol Green, Daniel Acosta, et al. "Cell culture systems andin vitro toxicity testing." Cytotechnology 8, no. 2 (June 1992): 129–76. http://dx.doi.org/10.1007/bf02525495.

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5

DelRaso, N. J. "In vitro methodologies for enhanced toxicity testing." Toxicology Letters 68, no. 1-2 (May 1993): 91–99. http://dx.doi.org/10.1016/0378-4274(93)90122-e.

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6

Prieto, Pilar. "Barriers, Nephrotoxicology and Chronic Testing In Vitro." Alternatives to Laboratory Animals 30, no. 2_suppl (December 2002): 101–5. http://dx.doi.org/10.1177/026119290203002s15.

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In many organs of the human body, there are effective physiological barriers which contribute to regulation of the uptake, transport and secretion of endogenous and exogenous materials. ECVAM is involved in the development of several in vitro models for detecting damage to various barriers, including, the renal epithelium, the intestinal barrier, and the blood–brain barrier, after acute and chronic exposure to chemicals and products of various kinds. Long-term toxicity testing is an important issue in toxicology. At present, there are no generally accepted in vitro models available for replaci

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7

Flint, Oliver P. "In Vitro Toxicity Testing: Purpose, Validation and Strategy." Alternatives to Laboratory Animals 18, no. 1_part_1 (November 1990): 11–18. http://dx.doi.org/10.1177/026119299001800103.1.

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The fullest potential for in vitro evaluation of toxicity will be realised in the context of the process of assessing the risk of human toxicity. This article is an attempt to clarify what contributions can be made by in vitro tests and what types of in vitro test can best be used. In vitro tests are clarified according to the type of biological endpoint evaluated, first into tests for general (‘basal’) cytotoxicity and, secondly, into tests for differentiated cell function. The role of each type of test is analysed and it is suggested that tests for general cytotoxicity, as opposed to differe

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8

Vinken, M. "Liver-based in vitro models for toxicity testing." Toxicology Letters 295 (October 2018): S7. http://dx.doi.org/10.1016/j.toxlet.2018.06.029.

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9

Jennings, P. "Kidney-based in vitro models for toxicity testing." Toxicology Letters 295 (October 2018): S7—S8. http://dx.doi.org/10.1016/j.toxlet.2018.06.030.

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10

Constant, S. "Lung-based in vitro models for toxicity testing." Toxicology Letters 295 (October 2018): S8. http://dx.doi.org/10.1016/j.toxlet.2018.06.031.

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11

Gutleb, A. C. "Three-dimensional models for in vitro toxicity testing." Toxicology Letters 295 (October 2018): S8. http://dx.doi.org/10.1016/j.toxlet.2018.06.033.

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12

Dover, R., W. R. Otto, J. Nanchahal, and D. J. Riches. "Toxicity testing of wound dressing materials in vitro." British Journal of Plastic Surgery 48, no. 4 (1995): 230–35. http://dx.doi.org/10.1016/0007-1226(95)90007-1.

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13

Rodriguez, Rosita J. "In vitro toxicity testing. Applications to safety evaluation." Toxicology Letters 63, no. 2 (November 1992): 221–23. http://dx.doi.org/10.1016/0378-4274(92)90014-b.

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14

Ackerman, Steven B., Gordon L. Stokes, R. James Swanson, Sherry P. Taylor, and Lori Fenwick. "Toxicity testing for human in vitro fertilization programs." Journal of In Vitro Fertilization and Embryo Transfer 2, no. 3 (September 1985): 132–37. http://dx.doi.org/10.1007/bf01131499.

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15

May, J. E., J. Xu, H. R. Morse, N. D. Avent, and C. Donaldson. "Toxicity testing: the search for an in vitro alternative to animal testing." British Journal of Biomedical Science 66, no. 3 (January 2009): 160–65. http://dx.doi.org/10.1080/09674845.2009.11730265.

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16

Watanabe, Masami. "Safety Evaluation and Toxicity Testing Using In Vitro Methods." Journal of Toxicological Sciences 16, SupplementII (1991): 91–95. http://dx.doi.org/10.2131/jts.16.supplementii_91.

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17

Vippola, M., GCM Falck, HK Lindberg, S. Suhonen, E. Vanhala, H. Norppa, K. Savolainen, A. Tossavainen, and T. Tuomi. "Preparation of nanoparticle dispersions for in-vitro toxicity testing." Human & Experimental Toxicology 28, no. 6-7 (June 2009): 377–85. http://dx.doi.org/10.1177/0960327109105158.

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Studies on potential toxicity of engineered nanoparticle (ENP) in biological systems require a proper and accurate particle characterization to ensure the reproducibility of the results and to understand biological effects of ENP. A full characterization of ENP should include various measurements such as particle size and size distribution, shape and morphology, crystallinity, composition, surface chemistry, and surface area of ENP. It is also important to characterize the state of ENP dispersions. In this study, four different ENPs, rutile and anatase titanium dioxides and short single- and m

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18

Smoot, E. Clyde, John O. Kucan, Allan Roth, Nat Mody, and Natalio Debs. "In Vitro Toxicity Testing for Antibacterials Against Human Keratinocytes." Plastic and Reconstructive Surgery 87, no. 5 (May 1991): 917–24. http://dx.doi.org/10.1097/00006534-199105000-00017.

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19

Simms, L., L. Czekala, M. Stevenson, G. Phillips, R. Tilley, K. Rudd, and T. Walele. "An in vitro approach to e-cigarette toxicity testing." Toxicology Letters 295 (October 2018): S118. http://dx.doi.org/10.1016/j.toxlet.2018.06.658.

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20

Orbach, Sophia M., Rebekah R. Less, Anjaney Kothari, and Padmavathy Rajagopalan. "In Vitro Intestinal and Liver Models for Toxicity Testing." ACS Biomaterials Science & Engineering 3, no. 9 (January 23, 2017): 1898–910. http://dx.doi.org/10.1021/acsbiomaterials.6b00699.

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21

Jarrell, John F., Margaret L. Sevcik, David C. Villeneuve, and Per O. Janson. "Toxicity testing using the isolated in vitro perfused ovary." Reproductive Toxicology 7 (January 1993): 63–68. http://dx.doi.org/10.1016/0890-6238(93)90070-n.

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22

Catroux, P., A. Rougier, K. G. Dossou, and M. Cottin. "The silicon microphysiometer for testing ocular toxicity in vitro." Toxicology in Vitro 7, no. 4 (July 1993): 465–69. http://dx.doi.org/10.1016/0887-2333(93)90048-a.

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23

Phalen, Robert F. "Commentary on ‘‘Toxicity Testing in the 21st Century: A vision and a Strategy’’." Human & Experimental Toxicology 29, no. 1 (January 2010): 11–14. http://dx.doi.org/10.1177/0960327109354660.

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Toxicity Testing in the 21st Century: A Vision and a Strategy (NRC, 2007) presents a bold plan for chemical toxicity testing that replaces whole-animal tests with cell-culture, genetic, other in-vitro techniques, computational methods, and human monitoring. Although the proposed vision is eloquently described, and recent advances in in-vitro and in-silico methods are impressive, it is difficult believe that replacing in-vitro testing is either practical or wise. It is not clear that the toxicity-related events that occur in whole animals can be adequately replicated using the proposed methods.

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24

Bhanushali, M., V. Bagale, A. Shirode, Y. Joshi, and V. Kadam. "An in-vitro toxicity testing - a reliable alternative to toxicity testing by reduction, replacement and refinement of animals." International Journal of Advances in Pharmaceutical Sciences 1, no. 1 (March 12, 2010): 15–31. http://dx.doi.org/10.5138/ijaps.2010.0976.1055.01002.

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25

Tabernilla, Andrés, Bruna dos Santos Rodrigues, Alanah Pieters, Anne Caufriez, Kaat Leroy, Raf Van Campenhout, Axelle Cooreman, et al. "In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach." International Journal of Molecular Sciences 22, no. 9 (May 10, 2021): 5038. http://dx.doi.org/10.3390/ijms22095038.

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The liver is among the most frequently targeted organs by noxious chemicals of diverse nature. Liver toxicity testing using laboratory animals not only raises serious ethical questions, but is also rather poorly predictive of human safety towards chemicals. Increasing attention is, therefore, being paid to the development of non-animal and human-based testing schemes, which rely to a great extent on in vitro methodology. The present paper proposes a rationalized tiered in vitro testing strategy to detect liver toxicity triggered by chemicals, in which the first tier is focused on assessing gen

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26

Northup, Sharon J. "Perspectives on In Vitro Toxicity for Medical Devices." Journal of the American College of Toxicology 7, no. 4 (July 1988): 481–89. http://dx.doi.org/10.3109/10915818809019521.

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In vitro toxicity testing has found widespread application in its use for screening materials for medical devices. Cytotoxicity tests, which have been in use for nearly 20 years, have been validated for intralaboratory repeatability, interlaboratory reproducibility, and correlation with acute animal toxicity assays. The three primary cytotoxicity assays, i.e., direct contact, agar diffusion, and elution tests, allow a selection between assay and material characteristics. Mutagenicity assays have had limited application to materials testing because of the insoluble nature of the materials and t

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27

Flatt, L., S. Hartvelt, M. Feliksik, T. Zwetsloot, G. Hendriks, T. Osterlund, and A. Jamalpoor. "P06-12 ReproTracker: Next generation in vitro developmental toxicity testing." Toxicology Letters 368 (September 2022): S117. http://dx.doi.org/10.1016/j.toxlet.2022.07.330.

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28

Herrala, M., M. Huovinen, E. Järvelä, M. Lahtela-Kakkonen, R. Räisänen, J. Yli-Öyrä, and J. Rysä. "P07-18 In vitro toxicity testing of environmental water contaminants." Toxicology Letters 368 (September 2022): S127. http://dx.doi.org/10.1016/j.toxlet.2022.07.361.

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29

Fentem, Julia H. "Book Review: In Vitro Toxicity Testing: Applications to Safety Evaluation." Alternatives to Laboratory Animals 20, no. 4 (October 1992): 581. http://dx.doi.org/10.1177/026119299202000417.

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30

Seibert, Hasso, Michael Gulden, and Jens-Uwe Voss. "Comparative Cell Toxicology: The Basis for In Vitro Toxicity Testing." Alternatives to Laboratory Animals 22, no. 3 (May 1994): 168–74. http://dx.doi.org/10.1177/026119299402200306.

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If “cell toxicology” is defined as the discipline aimed at studying the general principles of chemical interference with cellular structures and/or functions, then “comparative cell toxicology” may be defined as the study of the variety of responses to xenobiotics using: (a) different endpoints within one cell type; (b) cell types from different tissues from one species; and (c) homologous cell types from different species. If the full potential of in vitro models for toxicity testing is to be realised and the scientific basis for hazard assessment improved, then comparative cell toxicological

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31

Watanabe, Masami. "Toxicity and Effectiveness Testing of Drugs Using In Vitro Methods." Japanese Journal of Pharmacology 71 (1996): 44. http://dx.doi.org/10.1016/s0021-5198(19)36430-3.

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32

Bakand, Shahnaz, and Amanda Hayes. "Troubleshooting methods for toxicity testing of airborne chemicals in vitro." Journal of Pharmacological and Toxicological Methods 61, no. 2 (March 2010): 76–85. http://dx.doi.org/10.1016/j.vascn.2010.01.010.

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33

Ehnert, S., L. Schyschka, A. Noss, D. Knobeloch, J. Kleeff, P. Büchler, S. Gillen, et al. "Further characterization of autologous NeoHepatocytes for in vitro toxicity testing." Toxicology in Vitro 25, no. 6 (September 2011): 1203–8. http://dx.doi.org/10.1016/j.tiv.2011.05.013.

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34

Faria, João, Sabbir Ahmed, Karin G. F. Gerritsen, Silvia M. Mihaila, and Rosalinde Masereeuw. "Kidney-based in vitro models for drug-induced toxicity testing." Archives of Toxicology 93, no. 12 (October 29, 2019): 3397–418. http://dx.doi.org/10.1007/s00204-019-02598-0.

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Abstract The kidney is frequently involved in adverse effects caused by exposure to foreign compounds, including drugs. An early prediction of those effects is crucial for allowing novel, safe drugs entering the market. Yet, in current pharmacotherapy, drug-induced nephrotoxicity accounts for up to 25% of the reported serious adverse effects, of which one-third is attributed to antimicrobials use. Adverse drug effects can be due to direct toxicity, for instance as a result of kidney-specific determinants, or indirectly by, e.g., vascular effects or crystals deposition. Currently used in vitro

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35

Barile, F. A., P. J. Dierickx, and U. Kristen. "In vitro cytotoxicity testing for prediction of acute human toxicity." Cell Biology and Toxicology 10, no. 3 (June 1994): 155–62. http://dx.doi.org/10.1007/bf00757558.

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36

Kolárová, H., J. Mosinger, R. Lenobel, K. Kejlová, D. Jı́rová, and M. Strnad. "In vitro toxicity testing of supramolecular sensitizers for photodynamic therapy." Toxicology in Vitro 17, no. 5-6 (October 2003): 775–78. http://dx.doi.org/10.1016/s0887-2333(03)00094-8.

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37

Botham, P. A. "Book Reviews: In Vitro Toxicity Testing. Applications to Safety Evaluation." Human & Experimental Toxicology 13, no. 2 (February 1994): 142. http://dx.doi.org/10.1177/096032719401300217.

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38

Kimmel, Gary L. "Invited perspective: In vitro testing in developmental toxicity risk assessment." Teratology 58, no. 2 (August 1998): 25–26. http://dx.doi.org/10.1002/(sici)1096-9926(199808)58:2<25::aid-tera1>3.0.co;2-#.

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39

Combes, Robert, Christina Grindon, Mark T. D. Cronin, David W. Roberts, and John F. Garrod. "Integrated Decision-tree Testing Strategies for Acute Systemic Toxicity and Toxicokinetics with Respect to the Requirements of the EU REACH Legislation." Alternatives to Laboratory Animals 36, no. 1 (February 2008): 45–63. http://dx.doi.org/10.1177/026119290803600107.

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Liverpool John Moores University and FRAME conducted a joint research project, sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) system for the safety testing and risk assessment of chemicals. The project covered all the main toxicity endpoints associated with REACH. This paper focuses on the use of alternative (non-animal) methods (both in vitro and in silico) for acute systemic toxicity and toxicokinetic testing. The paper reviews in vitro tests based on basal cytotoxicity and

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40

Combes, Robert, Christina Grindon, Mark T. D. Cronin, David W. Roberts, and John F. Garrod. "Integrated Decision-tree Testing Strategies for Acute Systemic Toxicity and Toxicokinetics with Respect to the Requirements of the EU REACH Legislation." Alternatives to Laboratory Animals 36, no. 1_suppl (October 2008): 91–109. http://dx.doi.org/10.1177/026119290803601s08.

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Liverpool John Moores University and FRAME conducted a joint research project, sponsored by Defra, on the status of alternatives to animal testing with regard to the European Union REACH (Registration, Evaluation and Authorisation of Chemicals) system for the safety testing and risk assessment of chemicals. The project covered all the main toxicity endpoints associated with REACH. This paper focuses on the use of alternative (non-animal) methods (both in vitro and in silico) for acute systemic toxicity and toxicokinetic testing. The paper reviews in vitro tests based on basal cytotoxicity and

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41

Zavala, Jose, Anastasia N. Freedman, John T. Szilagyi, Ilona Jaspers, John F. Wambaugh, Mark Higuchi, and Julia E. Rager. "New Approach Methods to Evaluate Health Risks of Air Pollutants: Critical Design Considerations for In Vitro Exposure Testing." International Journal of Environmental Research and Public Health 17, no. 6 (March 23, 2020): 2124. http://dx.doi.org/10.3390/ijerph17062124.

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Air pollution consists of highly variable and complex mixtures recognized as major contributors to morbidity and mortality worldwide. The vast number of chemicals, coupled with limitations surrounding epidemiological and animal studies, has necessitated the development of new approach methods (NAMs) to evaluate air pollution toxicity. These alternative approaches include in vitro (cell-based) models, wherein toxicity of test atmospheres can be evaluated with increased efficiency compared to in vivo studies. In vitro exposure systems have recently been developed with the goal of evaluating air

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42

Neagu, Monica, Fabia Grisi, Alfio Pulvirenti, Rosana Simón-Vázquez, Carlos A. García-González, and Antonella Caterina Boccia. "Updated Aspects of Safety Regulations for Biomedical Applications of Aerogel Compounds—Compendia-Like Evaluation." Safety 9, no. 4 (November 20, 2023): 80. http://dx.doi.org/10.3390/safety9040080.

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Aerogels have recently started to be considered as “advanced materials”; therefore, as a general consideration, aerogels’ toxicity testing should focus on their functionality which resides in their nanoscale open internal porosity. To assess the hazards of organic aerogels, testing at three levels may characterize their biophysical, in vitro and in vivo toxicity, defining distinct categories of aerogels. At the first level of testing, their abiotic characteristics are investigated, and the best aerogel(s) is forwarded to be tested at level 2, wherein in vitro methodologies may mainly evaluate

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43

Lamb, J. C. "Reproductive Toxicity Testing: Evaluating and Developing New Testing Systems." Journal of the American College of Toxicology 4, no. 2 (March 1985): 163–71. http://dx.doi.org/10.3109/10915818509014511.

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Reproductive toxicity testing systems are used by national and international regulatory agencies. Protocols have not been standardized between agencies or even within certain agencies. Although there have been efforts at standardization, a certain amount of the differences between testing protocols is a reflection of the needs of the particular agency. New developments in in vitro techniques might lead to new test systems, but reproductive function is dependent upon the interaction of various cells and organs that cannot presently be copied in the test tube; this makes whole-animal testing sys

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44

Citi, Valentina, Eugenia Piragine, Simone Brogi, Sara Ottino, and Vincenzo Calderone. "Development of In Vitro Corneal Models: Opportunity for Pharmacological Testing." Methods and Protocols 3, no. 4 (November 2, 2020): 74. http://dx.doi.org/10.3390/mps3040074.

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The human eye is a specialized organ with a complex anatomy and physiology, because it is characterized by different cell types with specific physiological functions. Given the complexity of the eye, ocular tissues are finely organized and orchestrated. In the last few years, many in vitro models have been developed in order to meet the 3Rs principle (Replacement, Reduction and Refinement) for eye toxicity testing. This procedure is highly necessary to ensure that the risks associated with ophthalmic products meet appropriate safety criteria. In vitro preclinical testing is now a well-establis

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45

Bouwmeester, Manon C., Yu Tao, Susana Proença, Frank G. van Steenbeek, Roos-Anne Samsom, Sandra M. Nijmeijer, Theo Sinnige, et al. "Drug Metabolism of Hepatocyte-like Organoids and Their Applicability in In Vitro Toxicity Testing." Molecules 28, no. 2 (January 7, 2023): 621. http://dx.doi.org/10.3390/molecules28020621.

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Emerging advances in the field of in vitro toxicity testing attempt to meet the need for reliable human-based safety assessment in drug development. Intrahepatic cholangiocyte organoids (ICOs) are described as a donor-derived in vitro model for disease modelling and regenerative medicine. Here, we explored the potential of hepatocyte-like ICOs (HL-ICOs) in in vitro toxicity testing by exploring the expression and activity of genes involved in drug metabolism, a key determinant in drug-induced toxicity, and the exposure of HL-ICOs to well-known hepatotoxicants. The current state of drug metabol

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46

Kolossa, Marike, and Hasso Seibert. "Toxicity Testing by Means of Cryopreserved Bovine Spermatozoa." Alternatives to Laboratory Animals 19, no. 2 (April 1991): 204–8. http://dx.doi.org/10.1177/026119299101900210.

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The aim of the present study was to investigate the suitability of bovine spermatozoa cryopreserved in a “defined” medium as an in vitro model for the assessment of the cytotoxic potential of chemicals. The endpoints used for this purpose were motion activity and cellular ATP content. The evaluation of properties of cryopreserved sperm shortly after thawing and at the end of a one-hour incubation period, shows that the cryoprotective medium developed is able to provide suitable cellular material for cytotoxicity tests. Results from experiments employing substances with known modes of action ar

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47

Yan, Zhen-guang, Xin Zheng, Fu Gao, Jun-tao Fan, Shu-ping Wang, and Li-xin Yang. "A Framework for Ecotoxicity Testing in the 21st Century: Ecotox21." Applied Sciences 9, no. 3 (January 28, 2019): 428. http://dx.doi.org/10.3390/app9030428.

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To reduce the considerable investments of toxicity testing and protecting animal welfare, a new toxicity testing strategy based on response pathways of human cell lines has been proposed in the United States to evaluate the chemical exposure risks to human health. However, the in vitro high-throughput assays have not yet been fully applied in ecotoxicity testing. This paper proposes a framework for high-efficiency ecotoxicity testing strategies to evaluate the ecological risk of chemicals. It consists of pathway-based toxicity testing, embryo-based toxicity testing, and predictive toxicology a

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48

Li, Meng, Rui Han, Juan Li, Wenhui Wu, and Jianqi Gu. "Research Progress in Acute Oral Toxicity Testing Methods." International Journal of Biology and Life Sciences 6, no. 1 (May 29, 2024): 19–22. http://dx.doi.org/10.54097/nv9van65.

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Acute oral toxicity is the first phase of safety toxicological evaluation, with the median lethal dose (LD50) being the most commonly used assessment parameter. This paper aims to summarize and compare conventional methods for determining LD50 and alternative approaches, along with their respective advantages and disadvantages, to provide options for further toxicological studies. Alternative tests, which do not require the precise determination of LD50 values, minimize animal mortality to the greatest extent and reduce the waste of human and material resources, making them worthy of promotion

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49

Bakand, Shahnaz, Amanda Hayes, and Chris Winder. "An Integrated in Vitro Approach for Toxicity Testing of Airborne Contaminants." Journal of Toxicology and Environmental Health, Part A 70, no. 19 (August 31, 2007): 1604–12. http://dx.doi.org/10.1080/15287390701434604.

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50

Vinken, Mathieu, and Jan G. Hengstler. "Characterization of hepatocyte-based in vitro systems for reliable toxicity testing." Archives of Toxicology 92, no. 10 (August 23, 2018): 2981–86. http://dx.doi.org/10.1007/s00204-018-2297-6.

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