Relevant bibliographies by topics / Toxicology and medicinal chemistry

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Toxicology and medicinal chemistry'

Author: Grafiati
Published: 4 June 2021
Last updated: 14 February 2022

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Journal articles on the topic "Toxicology and medicinal chemistry"

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Timmerman, H., A. Bast, H. Van der Goot, N. P. E. Vermeulen, and F. J. Zeelen. "Comprehensive medicinal chemistry." Trends in Pharmacological Sciences 12 (January 1991): 167–68. http://dx.doi.org/10.1016/0165-6147(91)90535-z.

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Shaw, Subrata. "Welcome to the Journal of Medicinal Chemistry and Toxicology." Journal of Medicinal Chemistry and Toxicology 1, no. 1 (2016): 17. http://dx.doi.org/10.15436/2575-808x.16.1079.

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Foye, William O. "Medicinal chemistry, a biochemical approach." Trends in Pharmacological Sciences 6 (January 1985): 488. http://dx.doi.org/10.1016/0165-6147(85)90230-5.

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Leeson, P. D. "Progress in medicinal chemistry. volume 29." Trends in Pharmacological Sciences 13 (January 1992): 451–52. http://dx.doi.org/10.1016/0165-6147(92)90144-u.

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Jyoti, Divya Dheer, Davinder Singh, et al. "Thymol Chemistry: A Medicinal Toolbox." Current Bioactive Compounds 15, no. 5 (2019): 454–74. http://dx.doi.org/10.2174/1573407214666180503120222.

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Background: Thymol is a natural phenolic monoterpenoid widely used in pharmaceutical and food preservative applications. Thymol isomeric with carvacrol, extracted primarily from Thymus species (Trachyspermum ammi) and other plants sources such as Baccharisgrise bachii and Centipeda minima, has ethnopharmacological characteristics. <p></p> Methods: This review was prepared by analyzing articles published on thymol moiety in last decade and selected from Science Direct, Scopus, Pub Med, Web of Science and SciFinder. The selected articles are classified and gives brief introduction ab
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Metternich, Rainer, and Giorgio Tarzia. "Medicinal Chemistry: Defining Itself." ChemMedChem 3, no. 8 (2008): 1147–49. http://dx.doi.org/10.1002/cmdc.200800116.

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Blomme, Eric, and Shana J. Sturla. "Chemical Toxicology and Medicinal Chemistry: A Special Issue Promoting Scientific Advances for Safer Medicines, Part 1." Chemical Research in Toxicology 33, no. 1 (2020): 1. http://dx.doi.org/10.1021/acs.chemrestox.9b00496.

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Metternich, Rainer, and Giorgio Tarzia. "“Hot Spots” in Medicinal Chemistry." ChemMedChem 5, no. 8 (2010): 1159–62. http://dx.doi.org/10.1002/cmdc.201000266.

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Differding, Edmond. "50 Years European Federation for Medicinal Chemistry (EFMC) – The Ascent of Medicinal Chemistry in Europe." ChemMedChem 15, no. 24 (2020): 2338–51. http://dx.doi.org/10.1002/cmdc.202000691.

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Faruk Khan, M. O., Michael J. Deimling, and Ashok Philip. "Medicinal Chemistry and the Pharmacy Curriculum." American Journal of Pharmaceutical Education 75, no. 8 (2011): 161. http://dx.doi.org/10.5688/ajpe758161.

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Dissertations / Theses on the topic "Toxicology and medicinal chemistry"

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Ptchelintsev, Dmitri Stanislav. "Structure-activity relationship studies in chemoreception, toxicology and medicinal chemistry." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1060866168.

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Allen, Serena. "The Combined Neuropharmacology and Toxicology of Major 'Bath Salts' Constituents MDPV, Mephedrone, and Methylone." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3431.

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The synthetic cathinones, 3,4- methylenedioxypyrovalerone (MDPV), 4-methylmethcathinone (mephedrone), and 3,4- methylenedioxymethcathinone (methylone), gained worldwide notoriety as the psychoactive components of ‘bath salts;’ a marketing term used to circumvent federal drug laws and permit their legal sale. Previous studies have shown that these drugs share pharmacological characteristics with cocaine and the amphetamines, however, descriptions of their neurotoxic properties are limited. Moreover, while forensic analysis has revealed that the most frequently abused bath salts ‘brands’ contain
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Stice, Szabina A. "Speciation, Metabolism, Toxicity, and Protein-binding of Different Arsenic Species in Human Cells." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1203.

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Despite of its known toxicity and potential to cause cancer, arsenic has been proven to be a very important tool for the treatment of various refractory neoplasms. One of the promising arsenic-containing chemotherapeutic agents in clinical trials is Darinaparsin (dimethylarsinous glutathione, DMAIII(GS)). In order to understand its toxicity and therapeutic efficacy, the metabolism of Darinaparsin in human cancer cells was evaluated. With the aim of detecting all potential intermediates and final products of the biotransformation of Darinaparsin and other arsenicals, an analytical method employ
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Rafael, Venson. "Hollow-fibre liquid-phase microextraction : investigation into the potential use in clinical and forensic toxicology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8697/.

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Hollow-fibre liquid-phase microextraction (HF-LPME) was introduced in 1999 as a miniaturised version of liquid-liquid extraction (LLE) in order to reduce the consumption of organic solvents and offer an environmentally-friendly approach to extraction procedures. Since then, several studies have been published in the field of forensic and clinical toxicology applying the technique to a broad range of analytes; however more studies are necessary regarding its applicability to bioanalyses. The principle of HF-LPME is the extraction of analytes across a thin supported liquid membrane within the wa
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Mishra, Murli. "EXPLORATION OF THE SRX-PRX AXIS AS A SMALL-MOLECULE TARGET." UKnowledge, 2016. http://uknowledge.uky.edu/toxicology_etds/14.

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Lung cancer is a leading cause of cancer-related mortality irrespective of gender. The Sulfiredoxin (Srx) and Peroxiredoxin (Prx) are a group of thiol-based antioxidant proteins that plays an essential role in non-small cell lung cancer. Understanding the molecular characteristics of the Srx-Prx interaction may help design the strategies for future development of therapeutic tools. Based on existing literature and preliminary data from our lab, we hypothesized that the Srx plays a critical role in lung carcinogenesis and targeting the Srx-Prx axis or Srx alone may facilitate future development
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Lai, Kuei-Hung. "Studies on anti-leukemic terpenoids from medicinal mushrooms and marine sponges with ChemGPS-NP-based targets investigation of lead compounds." Doctoral thesis, Uppsala universitet, Avdelningen för farmakognosi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317554.

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This thesis investigates the anti-leukemic activity of terpenoids isolated from medicinal mushrooms and marine sponges, as well as their possible targets and mechanisms of action. In the first section, we focused on studying the triterpenoidal components of three triterpenoid-enriched medicinal mushrooms Antrodia cinnamomea, Ganoderma lucidum, and Poria cocos, which have been used in folk medicine for centuries and also developed into several contemporary marketed products. We isolated the major and characteristic triterpenoids from these mushrooms, together with six new lanostanoids (II-1–II-
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Eckenrode, Joseph Michael. "DEVELOPMENT OF MITHRAMYCIN ANALOGUES WITH IMPROVED EFFICACY AND REDUCED TOXICITY FOR TREATMENT OF ETS-DEPENDENT TUMORS IN EWING SARCOMA AND PROSTATE CANCER." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/107.

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Introduction: Genetic rearrangements in Ewing sarcoma, prostate, and leukemia cells result in activation of oncogenic ETS transcription factor fusions. Mithramycin (MTM) has been identified as an inhibitor of EWS-FLI1 transcription factor, a gene fusion product responsible for oncogenesis in Ewing sarcoma. Despite preclinical success, a phase I/II clinical trial testing MTM therapy in refractory Ewing sarcoma was terminated. Liver and blood toxicities resulted in dose de-escalation and sub-therapeutic exposures. However, the promise of selectively targeting oncogenic ETS transcription factors
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Al-Darraji, Ahmed Hamish Neamah. "AZITHROMYCIN THERAPY REDUCES CARDIAC INFLAMMATION AND MITIGATES ADVERSE CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacol_etds/30.

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Introduction: Myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide. Induced by cardiomyocyte death, MI initiates a prolonged and uncontrolled inflammatory response which impairs the healing process. Immune cells, such as macrophages, play a central role in organizing the early post-MI inflammatory response and the subsequent repair phase. Two activation states of macrophages have been identified with distinct and complementary functions (inflammatory vs. reparatory). This bimodal pattern of macrophage activation is an attractive therapeutic target to favora
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He, Qinghao. "The Degradation of Pharmaceutical Pollutants in Wastewater Catalyzed by Chloroperoxidase and the Construction of Chloroperoxidase H105R Mutant." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2540.

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Trace amounts of pharmaceuticals have been detected in water, from nanograms per liter to micrograms per liter, and have a negatively effect in the aquatic environment and an increased potential risk of drug poisoning for human and animals. In order to address the problem, drug degradation catalyzed by chloroperoxidase (CPO) has been investigated. CPO is a heme-containing glycoprotein secreted by the fungus, Caldariomyces fumago, it catalyzes two major types of oxidations, two one-electron oxidations as catalyzed by most peroxidases and two-electron oxidations which are rare for conventional p
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Valadon, Philippe. "Cytochromes P-450 et Activation Metabolique du Noyau Thiophene : exemple de l'acide tiénilique et de ses dérivés." Phd thesis, Université Pierre et Marie Curie - Paris VI, 1992. http://tel.archives-ouvertes.fr/tel-00651961.

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L'acide tiénilique (AT) est un diurétique responsable d'hépatite autoimmunes. Dans le sérum des patients on retrouve des autoanticorps (anti-LKM2) dirigés contre les cytochromes P450 impliquées dans la métabolisation de l'AT et de son isomère (TAI) La première partie concerne la détermination de la nature de l'entité réactive du TAI au moyen d'un piègeage par le mercaptoethanol. Deux sulfoxydes des dihydrothiophène ont été caractérisés qui nous permettent de proposer un sulfoxyde de thiophène. En présence d'un excès de mercaptoethanol, ces deux métabolites de piègeage évoluent en une successio
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Books on the topic "Toxicology and medicinal chemistry"

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Neuwinger, Hans Dieter. African ethnobotany: Poisons and drugs : chemistry, pharmacology, toxicology. Chapman & Hall, 1996.

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Paolo, Milani, Da Ros Tatiana, and SpringerLink (Online service), eds. Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes. Springer Science + Business Media B.V, 2008.

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1957-, Kumar M., and Gupta V. 1966-, eds. Heterocyclic chemistry. Springer, 1998.

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library, Wiley online, ed. Principles and Practice of Mixtures Toxicology. Wiley-VCH, 2010.

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Schulte, Jurgen. Fundamental Research in Ultra High Dilution and Homoeopathy. Springer Netherlands, 1998.

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Albee, Sarah. Poison: Deadly deeds, perilous professions, and murderous medicines. Crown Children's Books, 2017.

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Borchardt, Ronald T. Models for Assessing Drug Absorption and Metabolism. Springer US, 1996.

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Staines, Henry M. Treatment and Prevention of Malaria: Antimalarial Drug Chemistry, Action and Use. Springer Basel, 2012.

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American Chemical Society. Committee on Professional Training. Directory of graduate research 1999: Faculties, publications, and doctoral and master's theses in departments or divisions of chemistry, chemical engineering, biochemistry, medicinal/pharmaceutical chemistry, clinical chemistry, polymer science, food science, forensic science, marine science, toxicology, materials science, and environmental science at universities in the United States and Canada. American Chemical Society, 1999.

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Chambless, William. Fifty years of research and service: Haskell Laboratory for Toxicology and Industrial Medicine. E.I. du Pont de Nemours & Co., 1985.

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Book chapters on the topic "Toxicology and medicinal chemistry"

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Anastas, Nicholas D. "Green Toxicology." In Green Techniques for Organic Synthesis and Medicinal Chemistry. John Wiley & Sons, Ltd, 2012. http://dx.doi.org/10.1002/9780470711828.ch1.

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Heckel, Tobias, and Laura Suter-Dick. "Predictive Toxicology: Genetics, Genomics, Epigenetics, and Next-Generation Sequencing in Toxicology." In Methods and Principles in Medicinal Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527674183.ch08.

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Powley, Mark W. "CHAPTER 16. Toxicology and Drug Development." In The Handbook of Medicinal Chemistry. Royal Society of Chemistry, 2015. http://dx.doi.org/10.1039/9781782621836-00413.

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Mesens, Natalie. "The Zebrafish Model in Toxicology." In Methods and Principles in Medicinal Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527674183.ch11.

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Braggio, Simone, Mauro Corsi, Aldo Feriani, Stefano Fontana, Luciana Marocchio, and Caterina Virginio. "CHAPTER 15. Discovery Toxicology In Lead Optimisation." In The Handbook of Medicinal Chemistry. Royal Society of Chemistry, 2015. http://dx.doi.org/10.1039/9781782621836-00364.

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Suter-Dick, Laura, and Friedlieb Pfannkuch. "Introduction to Predictive Toxicology Tools and Methods." In Methods and Principles in Medicinal Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527674183.ch01.

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Mangiatordi, Giuseppe Felice, Angelo Carotti, Ettore Novellino, and Orazio Nicolotti. "A Round Trip from Medicinal Chemistry to Predictive Toxicology." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3609-0_19.

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Walz, Antje-Christine, Hans Peter Grimm, Christophe Meille, Antonello Caruso, Neil Parrott, and Thierry Lavé. "Role of Modeling and Simulation in Toxicology Prediction." In Methods and Principles in Medicinal Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2014. http://dx.doi.org/10.1002/9783527674183.ch04.

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Park, Tae-Joon, Jeffrey G. Martin, and Robert J. Linhardt. "Pharmacological Applications of Biocompatible Carbon Nanotubes and Their Emerging Toxicology Issues." In Medicinal Chemistry and Pharmacological Potential of Fullerenes and Carbon Nanotubes. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6845-4_12.

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Jarvis, Bruce B. "Chemistry and Toxicology of Molds Isolated from Water-Damaged Buildings." In Advances in Experimental Medicine and Biology. Springer US, 2002. http://dx.doi.org/10.1007/978-1-4615-0629-4_5.

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Conference papers on the topic "Toxicology and medicinal chemistry"

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Ahangar, A. G., R. J. Smernik, and R. S. Kookana. "Role of the chemistry of soil organic matter on the sorption of diuron." In ENVIRONMENTAL TOXICOLOGY 2008. WIT Press, 2008. http://dx.doi.org/10.2495/etox080341.

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Benito, Elena, Rocío Recio, Belén Begines, et al. "CASE STUDY: MEDICINAL CHEMISTRY." In 10th annual International Conference of Education, Research and Innovation. IATED, 2017. http://dx.doi.org/10.21125/iceri.2017.1425.

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Chou, Kuo-Chen. "Trends in Medicinal Chemistry." In MOL2NET 2017, International Conference on Multidisciplinary Sciences, 3rd edition. MDPI, 2017. http://dx.doi.org/10.3390/mol2net-03-04615.

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Gieré, Reto. "Mineralogy, Chemistry, and Toxicology of Particulate Emissions from Combustion Processes." In Goldschmidt2020. Geochemical Society, 2020. http://dx.doi.org/10.46427/gold2020.827.

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DAGO, Déliko. "Development of New 5-Arylidene-3-(arylmethyl)aminobutyl-2-thioxo-1,3-thiazolidine-4-one under Microwave Irradiation and Their Biological Effects on Protein Kinases and Tumoral Cell Lines." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a001.

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Donno, Dario, Maria Gabriella Mellano, Alessandro Cerutti, and Gabriele Beccaro. "Biomolecules and Natural Medicine Preparations: Analysis of New Sources of Bioactive Compounds from Ribes and Rubus spp. ." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a002.

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KOMARAGIRI, RAJESH. "Recycling of Drugs from Expired Drug Products." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2016. http://dx.doi.org/10.3390/ecmc-1-a003.

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Fruit, Corinne, Julien Godeau, Marine Harari, Sylvain Laclef, Vincent Levacher, and Thierry Besson. "Microwave-assisted C-H arylation of Quinazolin-4-one-type Precursors of Bioactive Heterocycles." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a004.

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KOMARAGIRI, RAJESH. "Recycling of Drugs from Expired Drug Products." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a005.

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Gadgoli, Chhaya, Lalit Sali, Mahesh Abhyankar, and Prachi Pathak. "Complex of zinc and lectins from seeds of Vigna radiata as potential anti-diabetic agent." In 1st International Electronic Conference on Medicinal Chemistry. MDPI, 2015. http://dx.doi.org/10.3390/ecmc-1-a006.

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Reports on the topic "Toxicology and medicinal chemistry"

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Ward, C. H. Environmental Toxicology and Chemistry. An International Journal. Volume 15, Number 11, November 1996,. Defense Technical Information Center, 1996. http://dx.doi.org/10.21236/ada332986.

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Munavalli, Shekar, Dennis K. Rohrbaugh, and H. D. Durst. Chemistry, Biochemistry, Pharmacology, and Toxicology of CS and Synthesis of Its Novel Analogs. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada474594.

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