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Dissertations / Theses on the topic 'Toxicology and medicinal chemistry'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Ptchelintsev, Dmitri Stanislav. "Structure-activity relationship studies in chemoreception, toxicology and medicinal chemistry." Case Western Reserve University School of Graduate Studies / OhioLINK, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=case1060866168.

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2

Allen, Serena. "The Combined Neuropharmacology and Toxicology of Major 'Bath Salts' Constituents MDPV, Mephedrone, and Methylone." Digital Commons @ East Tennessee State University, 2018. https://dc.etsu.edu/etd/3431.

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The synthetic cathinones, 3,4- methylenedioxypyrovalerone (MDPV), 4-methylmethcathinone (mephedrone), and 3,4- methylenedioxymethcathinone (methylone), gained worldwide notoriety as the psychoactive components of ‘bath salts;’ a marketing term used to circumvent federal drug laws and permit their legal sale. Previous studies have shown that these drugs share pharmacological characteristics with cocaine and the amphetamines, however, descriptions of their neurotoxic properties are limited. Moreover, while forensic analysis has revealed that the most frequently abused bath salts ‘brands’ contain

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3

Stice, Szabina A. "Speciation, Metabolism, Toxicity, and Protein-binding of Different Arsenic Species in Human Cells." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1203.

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Despite of its known toxicity and potential to cause cancer, arsenic has been proven to be a very important tool for the treatment of various refractory neoplasms. One of the promising arsenic-containing chemotherapeutic agents in clinical trials is Darinaparsin (dimethylarsinous glutathione, DMAIII(GS)). In order to understand its toxicity and therapeutic efficacy, the metabolism of Darinaparsin in human cancer cells was evaluated. With the aim of detecting all potential intermediates and final products of the biotransformation of Darinaparsin and other arsenicals, an analytical method employ

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4

Rafael, Venson. "Hollow-fibre liquid-phase microextraction : investigation into the potential use in clinical and forensic toxicology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8697/.

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Hollow-fibre liquid-phase microextraction (HF-LPME) was introduced in 1999 as a miniaturised version of liquid-liquid extraction (LLE) in order to reduce the consumption of organic solvents and offer an environmentally-friendly approach to extraction procedures. Since then, several studies have been published in the field of forensic and clinical toxicology applying the technique to a broad range of analytes; however more studies are necessary regarding its applicability to bioanalyses. The principle of HF-LPME is the extraction of analytes across a thin supported liquid membrane within the wa

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5

Mishra, Murli. "EXPLORATION OF THE SRX-PRX AXIS AS A SMALL-MOLECULE TARGET." UKnowledge, 2016. http://uknowledge.uky.edu/toxicology_etds/14.

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Lung cancer is a leading cause of cancer-related mortality irrespective of gender. The Sulfiredoxin (Srx) and Peroxiredoxin (Prx) are a group of thiol-based antioxidant proteins that plays an essential role in non-small cell lung cancer. Understanding the molecular characteristics of the Srx-Prx interaction may help design the strategies for future development of therapeutic tools. Based on existing literature and preliminary data from our lab, we hypothesized that the Srx plays a critical role in lung carcinogenesis and targeting the Srx-Prx axis or Srx alone may facilitate future development

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6

Lai, Kuei-Hung. "Studies on anti-leukemic terpenoids from medicinal mushrooms and marine sponges with ChemGPS-NP-based targets investigation of lead compounds." Doctoral thesis, Uppsala universitet, Avdelningen för farmakognosi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-317554.

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This thesis investigates the anti-leukemic activity of terpenoids isolated from medicinal mushrooms and marine sponges, as well as their possible targets and mechanisms of action. In the first section, we focused on studying the triterpenoidal components of three triterpenoid-enriched medicinal mushrooms Antrodia cinnamomea, Ganoderma lucidum, and Poria cocos, which have been used in folk medicine for centuries and also developed into several contemporary marketed products. We isolated the major and characteristic triterpenoids from these mushrooms, together with six new lanostanoids (II-1–II-

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7

Eckenrode, Joseph Michael. "DEVELOPMENT OF MITHRAMYCIN ANALOGUES WITH IMPROVED EFFICACY AND REDUCED TOXICITY FOR TREATMENT OF ETS-DEPENDENT TUMORS IN EWING SARCOMA AND PROSTATE CANCER." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacy_etds/107.

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Introduction: Genetic rearrangements in Ewing sarcoma, prostate, and leukemia cells result in activation of oncogenic ETS transcription factor fusions. Mithramycin (MTM) has been identified as an inhibitor of EWS-FLI1 transcription factor, a gene fusion product responsible for oncogenesis in Ewing sarcoma. Despite preclinical success, a phase I/II clinical trial testing MTM therapy in refractory Ewing sarcoma was terminated. Liver and blood toxicities resulted in dose de-escalation and sub-therapeutic exposures. However, the promise of selectively targeting oncogenic ETS transcription factors

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8

Al-Darraji, Ahmed Hamish Neamah. "AZITHROMYCIN THERAPY REDUCES CARDIAC INFLAMMATION AND MITIGATES ADVERSE CARDIAC REMODELING AFTER MYOCARDIAL INFARCTION." UKnowledge, 2019. https://uknowledge.uky.edu/pharmacol_etds/30.

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Introduction: Myocardial infarction (MI) remains the leading cause of morbidity and mortality worldwide. Induced by cardiomyocyte death, MI initiates a prolonged and uncontrolled inflammatory response which impairs the healing process. Immune cells, such as macrophages, play a central role in organizing the early post-MI inflammatory response and the subsequent repair phase. Two activation states of macrophages have been identified with distinct and complementary functions (inflammatory vs. reparatory). This bimodal pattern of macrophage activation is an attractive therapeutic target to favora

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9

He, Qinghao. "The Degradation of Pharmaceutical Pollutants in Wastewater Catalyzed by Chloroperoxidase and the Construction of Chloroperoxidase H105R Mutant." FIU Digital Commons, 2016. http://digitalcommons.fiu.edu/etd/2540.

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Trace amounts of pharmaceuticals have been detected in water, from nanograms per liter to micrograms per liter, and have a negatively effect in the aquatic environment and an increased potential risk of drug poisoning for human and animals. In order to address the problem, drug degradation catalyzed by chloroperoxidase (CPO) has been investigated. CPO is a heme-containing glycoprotein secreted by the fungus, Caldariomyces fumago, it catalyzes two major types of oxidations, two one-electron oxidations as catalyzed by most peroxidases and two-electron oxidations which are rare for conventional p

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10

Valadon, Philippe. "Cytochromes P-450 et Activation Metabolique du Noyau Thiophene : exemple de l'acide tiénilique et de ses dérivés." Phd thesis, Université Pierre et Marie Curie - Paris VI, 1992. http://tel.archives-ouvertes.fr/tel-00651961.

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L'acide tiénilique (AT) est un diurétique responsable d'hépatite autoimmunes. Dans le sérum des patients on retrouve des autoanticorps (anti-LKM2) dirigés contre les cytochromes P450 impliquées dans la métabolisation de l'AT et de son isomère (TAI) La première partie concerne la détermination de la nature de l'entité réactive du TAI au moyen d'un piègeage par le mercaptoethanol. Deux sulfoxydes des dihydrothiophène ont été caractérisés qui nous permettent de proposer un sulfoxyde de thiophène. En présence d'un excès de mercaptoethanol, ces deux métabolites de piègeage évoluent en une successio

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11

Cao, William Sam. "Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro." Scholarly Commons, 2015. https://scholarlycommons.pacific.edu/uop_etds/131.

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The risks of damage to the developing nervous system of many chemicals are not known because these studies often require costly and time-consuming multi-generational animal experiments. Pluripotent stem cell-based systems can facilitate developmental neurotoxicity studies because disturbances in nervous system development can be modeled in vitro. In this study, neurons derived from embryonal carcinoma (EC) and induced pluripotent stem (iPS) cells, were first characterized to establish their suitability for developmental neurotoxicity studies. The EC stem cell line, TERA2.cl.SP-12, was differen

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12

Wang, Yu. "Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling." Scholarly Commons, 2013. https://scholarlycommons.pacific.edu/uop_etds/151.

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A novel aryl hydrocarbon receptor nuclear translocator (ARNT)-interacting peptide (Ainpl) was characterized from human liver cDNA library using phage display. Ainpl suppresses hypoxia inducible factor-1a (HIF-1α) signaling pathway through an ARNTdependent manner. HIF-1α is known to be overexpressed in more than 90% of solid tumors, and the inhibition of HIF-1α is proved as an effective approach to suppress tumor growth. ARNT, as the obligatory heterodimeric partner of HIF-1α for downstream gene activation, was used as a bait to screen for Ainpl. Ainpl specifically interacts with the helix-loop

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13

Rajarathinam, Kayathri. "Nutraceuticals based computational medicinal chemistry." Licentiate thesis, KTH, Teoretisk kemi och biologi, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-122681.

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In recent years, the edible biomedicinal products called nutraceuticals have been becoming more popular among the pharmaceutical industries and the consumers. In the process of developing nutraceuticals, in silico approaches play an important role in structural elucidation, receptor-ligand interactions, drug designing etc., that critically help the laboratory experiments to avoid biological and financial risk. In this thesis, three nutraceuticals possessing antimicrobial and anticancer activities have been studied. Firstly, a tertiary structure was elucidated for a coagulant protein (MO2.1) of

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14

Stamatkin, Christopher W. "PHOSPHATIDYLINOSITOL 3-KINASE (PI3K) AS A THERAPEUTIC TARGET IN NSCLC." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/58.

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Deregulated activation of phosphatidylinositol 3-kinase (PI3K) pathway is central to many human malignancies. The functions of this pathway are critical for normal cell metabolism, proliferation, and survival. In lung cancers, the PI3K pathway activity is often aberrantly driven by multiple mutations, including EGFR, KRAS, and PIK3CA. Molecules targeting the PI3K pathway are intensely investigated as potential anti-cancer agents. Although inhibitors of the pathway are currently in clinical trials, rational and targeted use of these compounds, alone or in combination, requires an understanding

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15

Shi, Dong-Fang. "The medicinal chemistry of antitumour benzazoles." Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283645.

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16

Brown, Stacy D., Andy Coop, Paul Trippier, and Eric Walters. "Contemporary Approaches For Teaching Medicinal Chemistry." Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etsu-works/5251.

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As the profession of pharmacy has transitioned from a chemistry-centered profession to a patient-centered profession, the role of medicinal chemistry in the curriculum has evolved. There is decreased emphasis on memorization of chemical structures, and priority placed on relating these structures to ADME, physical properties, and pharmacodynamics. Simultaneously, the delivery of this content has shifted from traditional lecture format to other styles. Here we discuss some new approaches to teaching medicinal chemistry.

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17

Brown, Dustin Paul. "TARGET-DIRECTED BIOSYNTHETIC EVOLUTION: REDIRECTING PLANT EVOLUTION TO GENOMICALLY OPTIMIZE A PLANT’S PHARMACOLOGICAL PROFILE." UKnowledge, 2015. http://uknowledge.uky.edu/neurobio_etds/13.

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The dissertation describes a novel method for plant drug discovery based on mutation and selection of plant cells. Despite the industry focus on chemical synthesis, plants remain a source of potent and complex bioactive metabolites. Many of these have evolved as defensive compounds targeted on key proteins in the CNS of herbivorous insects, for example the insect dopamine transporter (DAT). Because of homology with the human DAT protein some of these metabolites have high abuse potential, but others may be valuable in treating drug dependence. This dissertation redirects the evolution of a nat

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18

Park, Sung H. "High Affinity Block of ICl,swell by Thiol-Reactive Small Molecules." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4433.

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Ebselen (Ebs) is considered as a glutathione peroxidase (GPx) mimetic and primarily thought to function by scavenging intracellular reactive oxygen species (ROS). Previous to our work, Deng et al. (2010a) demonstrated complete block of ICl,swell with 15 microM Ebs following endothelin-1 (ET-1) induced activation of the current in cardiomyocytes. This block was presumed to take effect mainly via the quenching of ROS. Nonetheless, our work with DI TNC1 astrocytes strongly emphasizes that Ebs might function by an alternative mechanism based on its kinetic profile in blocking ICl,swell. Our experi

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19

Akay, Senol. "Diagnosis and Inhibition Tools in Medicinal Chemistry." Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/chemistry_diss/41.

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Cell surface saccharides are involved in a variety of essential biological events. Fluorescent sensors for saccharides can be used for detection, diagnosis, analysis and monitoring of pathological processes. The boronic acid functional group is known to bind strongly and reversibly to compounds with diol groups, which are commonly found on saccharides. Sensors that have been developed for the purpose of saccharide recognition have shown great potential. However, they are very hydrophobic and this lack of essential water-solubility makes them useful in biological applications. The first section

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20

Brown, Stacy D. "Using Guided Inquiry to Teach Medicinal Chemistry." Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/5249.

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21

Kristovich, Robert Lee. "Chemistry and toxicology of respirable airborne particulates." Connect to this title online, 2004. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1100898370.

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Thesis (Ph. D.)--Ohio State University, 2004.<br>Title from first page of PDF file. Document formatted into pages; contains xvii, 260 p.; also includes graphics (some col.). Includes bibliographical references (p. 242-260).

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22

Gal, Aharon. "The toxicology of nitric oxide In vitro." Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/39614.

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23

Lunga, Mayibongwe J. "A medicinal chemistry study in nitrogen containing heterocycles." Thesis, Rhodes University, 2018. http://hdl.handle.net/10962/63521.

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24

Elboray, Elghareeb Elshahat Elghareeb. "Catalytic cascades creating novel architecture for medicinal chemistry." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/8036/.

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The thesis comprises five chapters. Chapter one, the introduction, starts with a brief discussion of the more famous Pd catalysed reactions and their relevance to Pd as a catalyst in allene chemistry. The main part of the introduction reviews the recent work in Pd catalysed allene chemistry (formation of C-C, C-O and C-N bonds) and its importance in both synthetic and natural product syntheses. The second chapter “results and discussion” discusses the author own work including the selection of a broad series of novel substrates chosen to enable a wide range of multicomponent cascades to be des

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25

Li, Ju-Yun. "Quantitative structure-activity relationship studies in medicinal chemistry." Case Western Reserve University School of Graduate Studies / OhioLINK, 1995. http://rave.ohiolink.edu/etdc/view?acc_num=case1062596938.

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26

Waghela, M. B. "Pyrrolizine derivatives of potential medicinal interest." Thesis, De Montfort University, 1986. http://hdl.handle.net/2086/13287.

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27

Njaria, Paul Magutu. "Antimycobacterial 2-aminoquinazolinones and benzoxazole-based oximes: synthesis, biological evaluation, physicochemical profiling and supramolecular derivatization." Doctoral thesis, University of Cape Town, 2017. http://hdl.handle.net/11427/26954.

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Tuberculosis (TB) is a life-threatening infectious disease caused by Mycobacterium tuberculosis (Mtb). Globally, TB is a major public health burden with an estimated 10.4 million new cases and 1.8 million deaths reported in 2015. Although TB is curable, the treatment options currently available are beset by numerous shortcomings such as lengthy and complex treatment regimens, drug-drug interactions, drug toxicities, as well as emergence of widespread multi-drug resistance. Therefore, there is an urgent and compelling need to develop new, more effective, safer drugs with novel mechanisms of act

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28

Chen, Dianne Tzu-Hsiu. "Phytochemical studies on traditional medicinal plants with antimalarial activities." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/21853.

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The active antimalarial principles of three traditional medicinal plants, Passerina obtusifolia (Thymelaeaceae), Tetradenia riparia (Labiatea) and Xerophyta retinervis (V elloziaceae) were investigated by employing bioassay guided fractionation. Two novel compounds and five known constituents were isolated from the active fractions of these three plants. The types of compounds isolated included: three triterpenoids (20(29)-Lupene-3α,28- diol (30), 20(29)-Lupene-3α, 16β,28-triol (32) and 3β-Hydroxy-20(29)-Lupen-28-oic acid (42)); two diterpenoids (8-Abietene-7 β,13 β -diol (45) and cariocal (51

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29

Ni, Nanting. "Application of Boronic Acids in Medicinal Chemistry (Inhibitors, Sensors)." Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/chemistry_diss/34.

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It is well known boronic acids have its unique chemistry and related applications in organic synthesis. The boronic acid functionally group also plays very important roles in medicinal chemistry and chemical biology. For example, boronic acids have been developed as potential therapeutic agents, chemical biology tools. All these applications are directly related to the unique electronic and chemical properties of the boronic acid group. Herein, several application of boronic acids have been studied: 1) several groups of compounds were found as bacterial quorum sensing inhibitors; 2) a boronate

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30

Baxter-Jones, C. S. "Some aspects of the medicinal chemistry of immunomodulatory compounds." Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.235379.

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31

Foster, R. W. "Sustainable approaches to novel heterocyclic scaffolds for medicinal chemistry." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1470876/.

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This thesis investigates new methods for the environmentally sustainable synthesis of heterocyclic scaffolds for application in medicinal chemistry. Chapter I introduces general principles of sustainability in synthetic organic chemistry. This includes the characterization and application of sustainable solvents and the use of biomass feedstocks in synthesis. Chapter II explores the synthesis of substituted isoindolinones via a ruthenium-catalyzed alkyne cyclotrimerization. The introduction details the synthesis and medicinal application of isoindolinones and describes previous research involv

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32

Sherer, Christopher. "A multidisciplinary investigation into the design, synthesis and evaluation of a novel class of anti-glioblastoma drug fragments." Thesis, University of Central Lancashire, 2017. http://clok.uclan.ac.uk/20462/.

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Cancer is the second biggest global killer,[1,2] with cancers of the brain and central nervous system accounting for a disproportionately high number of deaths.[3] The most prolific cancer of the central nervous system is glioblastoma, for which prognosis is still very poor. In this project, analogues of two lead compounds with known activity against glioblastoma cell lines (compounds 4 and 5, Figure 1) were produced in order to develop structure-activity relationships and discover compounds with superior activities against glioblastoma. Figure 1 - The structures of the lead compounds 4 and 5

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33

Orrling, Kristina M. "On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-101356.

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34

Yu, Wenyuan. "Reaction Mechanisms and Synthesis of Oxidized Lipids." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1377387469.

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35

Duffin, Roger. "Molecular toxicology studies on the quartz hazard." Thesis, Edinburgh Napier University, 2003. http://researchrepository.napier.ac.uk/Output/2777.

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Silicon makes up almost 28% of the Earth's crust and within that crust, quartz (crystalline silica) is one of the most abundant minerals. Exposure to quartz can occur in a number of occupations, including the mining and construction industries in which respirable quartz particles are generated and become airborne. Inhalation of quartz can lead to the fibrosing lung disease silicosis and cancer. Silicosis has been recognised for many decades as one of the most prevalent occupational lung diseases. In 1997, an IARC working Group classified quartz as a class 1 lung carcinogen, but only in some in

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36

Di, Martino Giovanni Paolo <1985&gt. "Computational Methods in Biophysics and Medicinal Chemistry: Applications and Challenges." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6329/.

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In this thesis I described the theory and application of several computational methods in solving medicinal chemistry and biophysical tasks. I pointed out to the valuable information which could be achieved by means of computer simulations and to the possibility to predict the outcome of traditional experiments. Nowadays, computer represents an invaluable tool for chemists. In particular, the main topics of my research consisted in the development of an automated docking protocol for the voltage-gated hERG potassium channel blockers, and the investigation of the catalytic mechanism of the hum

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37

Holloway, C. M. "Aspects of the medicinal chemistry associated with the ergopeptide alkaloids." Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.373332.

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38

Brown, Stacy D. "A Process-Oriented Guided Inquiry Approach to Teaching Medicinal Chemistry." Digital Commons @ East Tennessee State University, 2010. https://doi.org/10.5688/aj7407121.

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Objective: To integrate process-oriented guided-inquiry learning (POGIL) team-based activities into a 1-semester medicinal chemistry course for doctor of pharmacy (PharmD) students and determine the outcomes.

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39

Chau, Yasmin-Pei(Yasmin-Pei Kamal). "Biosynthesis and medicinal chemistry of therapeutically promising plant natural products." Thesis, Massachusetts Institute of Technology, 2019. https://hdl.handle.net/1721.1/122839.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>Modern molecular biology, biochemical, and chemical techniques have made it possible to identify individual natural products that possess pharmacological activity from medicinal plants. While approximately 50% of all new FDA-approved small molecule therapeutics in the past 40 years were natural products or natural product analogs, challenges including limited natural resources and the difficulty of solving the tota

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40

Srivastava, Sanjay. "Structure-activity relationship studies in medicinal chemistry and drug design." Case Western Reserve University School of Graduate Studies / OhioLINK, 1992. http://rave.ohiolink.edu/etdc/view?acc_num=case1056054628.

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41

Baig, Ghouse U. "The medicinal chemistry of bicyclic systems containing a NNN bond." Thesis, Aston University, 1986. http://publications.aston.ac.uk/12464/.

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42

Rafael, Christopher Carlos Ferreira. "Synthesis of chromium carbene scaffolds for use in medicinal chemistry." Thesis, Rhodes University, 2014. http://hdl.handle.net/10962/d1010863.

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This study involves using methyllithium to synthesize Fischer carbene complexes as precursors for metal templated α,β-unsaturated complexes with potential as acceptors in the Baylis Hillman reaction as well as in Dötz benzannulation. Fischer carbene complexes contain low oxidation state metal centers, are electrophilic in nature and are stabilized by π-donating substituents such as alkoxy and amino groups. The increased electron withdrawing nature of the metal carbonyl moiety was expected to improve the rates of reaction compared to organic carbonyls. Four Fischer carbenes were synthesized via

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43

Schwehm, Carolin Maria. "Synthesis of 3-dimensional scaffolds for application in medicinal chemistry." Thesis, University of Nottingham, 2016. http://eprints.nottingham.ac.uk/32362/.

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In this thesis the successful synthesis of a novel tricyclic scaffold containing a ring fused triazole and piperidine will be discussed and furthermore its utility as a new potential privileged structure will be evaluated. As starting material for the synthesis of the considered scaffolds the commercially available ethyl 4-oxopiperidine-1-carboxylate 108 was used. Piperidone 108 was converted into scaffolds 96, 97 and 98 alternating the ring size (n=1, 2, 3) of the fused bicyclic ring. This tricyclic triazole scaffold was incorporated into known biologically active molecules (Sitaglitpin, a DP

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44

Lima, Barbosa Ana Soraya. "Organometallic compounds of tin and ruthenium : applications in medicinal chemistry." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF029.

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Nous avons synthétisé des composés d'étain avec des acides undécylénique, ricinoléique et caprylique. Ils ont une activité importante contre certaines souches de microrganismes, puisque ils agissent pour certains d’entre eux à des concentrations nanomolaires. Staphylococcus aureus semble être 4000 fois plus sensible à leur toxicité que les cellules de mammifères. Nous avons obtenu des composés du ruthénium qui présentent cytotoxicité contre des cellules cancéreuses suivant un mécanisme d'action différent de ceux observés pour le Cisplatine ou d'autres composés de Ru, grâce à leur grande stabil

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45

Thompson, Meghan L. "Physicochemical and Structural Analysis of Polymers as Putative Drugs." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/4061.

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Sulfated low molecular weight lignins (LMWLs) have shown good activity as anticoagulants by allosterically inhibiting thrombin, as well as promising agents for treating emphysema through inhibition of elastolysis, oxidation, and inflammation. Sulfated LMWLs are chemo-enzymatically synthesized from starting monomers caffeic, ferulic, and sinapic acid into sulfated dehydropolymers known as CDS, FDS, and SDS. To further the LMWLs’ development as drugs, their structural composition and physicochemical characteristics were defined in this work. The molecular weight distribution profile of the sulfa

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46

MacGregor, James Orrock. "Some chemistry of muconaldehyde pertinent to the toxicology of benzene." Thesis, University of Newcastle Upon Tyne, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261267.

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47

Segretti, Natanael Dante. "Planejamento e síntese de tuberculostáticos potenciais com base na estrutura de maltosiltransferase (GlgE) de Mycobacterium tuberculosis." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/9/9138/tde-24042017-101741/.

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A tuberculose (TB) é uma doença infectocontagiosa causada principalmente pelo Mycobacterium tuberculosis (Mtb). A TB era uma doença considerada em vias de extinção, porém sua incidência voltou a aumentar devido a diversos fatores, como o fluxo migratório dos chamados \"Países Reservatórios\" e a pandemia da AIDS. Em 2013, a OMS estimou 9 milhões de novos casos de TB e 1,5 milhões de mortes. A multirresistência aos quimioterápicos disponíveis justifica a procura por novos tuberculostáticos. Face ao exposto, o trabalho objetivou a síntese de potenciais inibidores da maltosiltransferase (GlgE), u

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Hartman, Alwin Mathijs [Verfasser], and A. K. H. [Akademischer Betreuer] Hirsch. "New applications of dynamic combinatorial chemistry to medicinal chemistry / Alwin Mathijs Hartman ; Betreuer: A.K.H. Hirsch." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2019. http://d-nb.info/1201647282/34.

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Peterson, Kristina L. "Advances in flow extraction techniques : applications in forensic toxicology /." Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/11552.

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Fitzgerald, Leona. "The preparation of novel pyrrolo[2,1-c][1,4]benzodiazepine building blocks and their application to the synthesis of A-to C-ring linked PDB oligomers." Thesis, University of Nottingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288994.

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