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Journal articles on the topic 'Toxicology and medicinal chemistry'

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1

Timmerman, H., A. Bast, H. Van der Goot, N. P. E. Vermeulen, and F. J. Zeelen. "Comprehensive medicinal chemistry." Trends in Pharmacological Sciences 12 (January 1991): 167–68. http://dx.doi.org/10.1016/0165-6147(91)90535-z.

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2

Shaw, Subrata. "Welcome to the Journal of Medicinal Chemistry and Toxicology." Journal of Medicinal Chemistry and Toxicology 1, no. 1 (September 7, 2016): 17. http://dx.doi.org/10.15436/2575-808x.16.1079.

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3

Foye, William O. "Medicinal chemistry, a biochemical approach." Trends in Pharmacological Sciences 6 (January 1985): 488. http://dx.doi.org/10.1016/0165-6147(85)90230-5.

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4

Leeson, P. D. "Progress in medicinal chemistry. volume 29." Trends in Pharmacological Sciences 13 (January 1992): 451–52. http://dx.doi.org/10.1016/0165-6147(92)90144-u.

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5

Jyoti, Divya Dheer, Davinder Singh, Gulshan Kumar, Manvika Karnatak, Suresh Chandra, Ved Prakash Verma, and Ravi Shankar. "Thymol Chemistry: A Medicinal Toolbox." Current Bioactive Compounds 15, no. 5 (January 3, 2019): 454–74. http://dx.doi.org/10.2174/1573407214666180503120222.

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Background: Thymol is a natural phenolic monoterpenoid widely used in pharmaceutical and food preservative applications. Thymol isomeric with carvacrol, extracted primarily from Thymus species (Trachyspermum ammi) and other plants sources such as Baccharisgrise bachii and Centipeda minima, has ethnopharmacological characteristics. <p></p> Methods: This review was prepared by analyzing articles published on thymol moiety in last decade and selected from Science Direct, Scopus, Pub Med, Web of Science and SciFinder. The selected articles are classified and gives brief introduction about thymol and its isolation, illustrates its natural as well as synthetic sources, and also therapeutic benefits of thymol worldwide <p></p> Results: Thymol has been covering different endeavors such as antimicrobial, antioxidant, antiinflammatory, antibacterial, antifungal, antidiarrhoeal, anthelmintic, analgesic, digestive, abortifacient, antihypertensive, spermicidal, depigmenting, antileishmanial, anticholinesterase, insecticidal and many others. This phenolic compound is among the essential scaffolds for medicinal chemists to synthesize more bio-active molecules by further derivatization of the thymol moiety. <p></p> Conclusion: Thymol is an interesting scaffold due to its different activities and derivatization of thymol is proved to enhance its biological activities. However, more robust, randomised, controlled clinical trials would be desirable with well-characterised thymol preparations to corroborate its beneficial effects in diseased patients. Moreover, in view of the potential use of thymol and thymol-rich essential oils in the treatment of human infections, comprehensive studies on chronic and acute toxicity and also teratogenicity are to be recommended.
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6

Metternich, Rainer, and Giorgio Tarzia. "Medicinal Chemistry: Defining Itself." ChemMedChem 3, no. 8 (August 18, 2008): 1147–49. http://dx.doi.org/10.1002/cmdc.200800116.

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7

Blomme, Eric, and Shana J. Sturla. "Chemical Toxicology and Medicinal Chemistry: A Special Issue Promoting Scientific Advances for Safer Medicines, Part 1." Chemical Research in Toxicology 33, no. 1 (January 21, 2020): 1. http://dx.doi.org/10.1021/acs.chemrestox.9b00496.

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8

Metternich, Rainer, and Giorgio Tarzia. "“Hot Spots” in Medicinal Chemistry." ChemMedChem 5, no. 8 (May 11, 2010): 1159–62. http://dx.doi.org/10.1002/cmdc.201000266.

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9

Differding, Edmond. "50 Years European Federation for Medicinal Chemistry (EFMC) – The Ascent of Medicinal Chemistry in Europe." ChemMedChem 15, no. 24 (October 29, 2020): 2338–51. http://dx.doi.org/10.1002/cmdc.202000691.

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10

Faruk Khan, M. O., Michael J. Deimling, and Ashok Philip. "Medicinal Chemistry and the Pharmacy Curriculum." American Journal of Pharmaceutical Education 75, no. 8 (October 10, 2011): 161. http://dx.doi.org/10.5688/ajpe758161.

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11

Zeelen, F. J. "Molecular biological techniques make an impact on medicinal chemistry." Trends in Pharmacological Sciences 10, no. 12 (December 1989): 472. http://dx.doi.org/10.1016/0165-6147(89)90039-4.

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12

Zimmermann, Marc, Juliane Fluck, Le Thi, Corinna Kolarik, Kai Kumpf, and Martin Hofmann. "Information Extraction in the Life Sciences: Perspectives for Medicinal Chemistry, Pharmacology and Toxicology." Current Topics in Medicinal Chemistry 5, no. 8 (August 1, 2005): 785–96. http://dx.doi.org/10.2174/1568026054637692.

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13

Dove, Stefan, Roland Seifert, Sigurd Elz, and Armin Buschauer. "Frontiers in Medicinal Chemistry in Regensburg." ChemMedChem 3, no. 8 (August 18, 2008): 1181–84. http://dx.doi.org/10.1002/cmdc.200800114.

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14

Timmerman, H., J. Wilting, M. Th M. Tulp, J. Kelder, Pramod R. Saxena, J. M. van Nueten, W. J. Janssens, et al. "Abstracts of papers medicinal chemistry meeting." Pharmaceutisch Weekblad 10, no. 6 (December 1988): 300–308. http://dx.doi.org/10.1007/bf02219673.

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15

Darlison, M. G., A. N. Bateson, R. J. Harvey, W. Wisden, E. A. Barnard, H. Loosfelt, M. Atger, et al. "Abstracts of papers Medicinal chemistry meeting." Pharmaceutisch Weekblad 11, S1 (February 1989): M1—M12. http://dx.doi.org/10.1007/bf02196049.

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16

Lambrecht, G., E. Mutschler, J. A. D. M. Tonnaer, Th de Boer, A. M. L. van Delft, G. Mihm, J. Kroon, et al. "Abstracts of papers medicinal chemistry meeting." Pharmaceutisch Weekblad 10, no. 2 (April 1988): 96–97. http://dx.doi.org/10.1007/bf01962687.

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17

Yue, Jianmin. "Review of Handbook of Chinese Medicinal Plants/Chemistry, Pharmacology, Toxicology. Volumes 1 and 2." Chinese Journal of Chemistry 29, no. 8 (August 2011): 1774. http://dx.doi.org/10.1002/cjoc.201190243.

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18

Soudijn, W. "Research in the division of medicinal chemistry." Pharmaceutisch Weekblad Scientific Edition 7, no. 2 (April 1985): 71–74. http://dx.doi.org/10.1007/bf02106131.

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19

Schepmann, Dirk, and Bernhard Wünsch. "Frontiers in Medicinal Chemistry 2010: The Highlights." ChemMedChem 5, no. 6 (May 11, 2010): 949–54. http://dx.doi.org/10.1002/cmdc.201000193.

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20

Bunch, Lennart. "Bioisosteres in Medicinal Chemistry. Edited byNathan Brown." ChemMedChem 8, no. 6 (March 28, 2013): 1012. http://dx.doi.org/10.1002/cmdc.201300117.

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21

Folkers, Gerd. "Synthesis in medicinal chemistry, a future orphan discipline?" Pharmaceutica Acta Helvetiae 68, no. 3 (January 1994): 143. http://dx.doi.org/10.1016/0031-6865(94)90036-1.

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22

Alsharif, Naser Z., Kimberly A. Galt, Ahmed Mehanna, Robert Chapman, and Alaba M. Ogunbadeniyi. "Instructional Model to Teach Clinically Relevant Medicinal Chemistry." American Journal of Pharmaceutical Education 70, no. 4 (September 2006): 91. http://dx.doi.org/10.5688/aj700491.

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23

Gouramma Patil and Sharanabasappa B Patil. "Biological synthesis of Nanoparticles from Medicinal Plants: Recent Studies." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (January 13, 2021): 344–49. http://dx.doi.org/10.26452/ijrps.v12i1.4142.

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In a recent trend, nanotechnology has been developed to be an important field of research in various fields like medicinal chemistry, pharmaceuticals and all. On the other hand, compared to chemical method of synthesis, method of synthesis of nanoparticles by green method is simple, effective & ecofriendly. Plant extracts are obtained from the plant, creep, cereals, etc. generally natural extracts are prepared by decoction method or solid powder formation method. The natural extracts are very much effective in the medicinal approach. The study of Nano sized particles towards natural extracts has given a novel way in the field of medicines. So from the nanomaterials of natural extracts, one can expect still good effective results. As we know that preparation of nanoparticles through green approach is one of the good selections in the view of betterment of ecology. Therefore by taking aqueous extracts of medicinal plants’ parts and metal ions, nanoparticles can be synthesized. The plant extract and metal ions are taken in a fixed ratio and keep at room temperature for the reduction. The Changes in the Color confirmed the formation of nanoparticles. Further, the synthesized nanoparticles were characterized by UV, EPMA, XRD and FTIR data.
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24

Alsharif, Naser Z., and Victoria F. Roche. "Promoting key interactions in a distance medicinal chemistry course." Currents in Pharmacy Teaching and Learning 2, no. 2 (March 2010): 114–25. http://dx.doi.org/10.1016/j.cptl.2010.01.003.

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25

Timmerman, Henk, and Noel J de Souza. "Medicinal Chemistry Teaching and Training: A Continuous Adaptation." ChemMedChem 4, no. 7 (July 6, 2009): 1055–58. http://dx.doi.org/10.1002/cmdc.200900128.

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26

Auberson, Yves P. "EFMC, Medicinal Chemistry and Chemical Biology in Europe." ChemMedChem 15, no. 24 (September 3, 2020): 2334–37. http://dx.doi.org/10.1002/cmdc.202000178.

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27

Soudijn, W. "The role of medicinal chemistry in drug research." Pharmaceutisch Weekblad Scientific Edition 13, no. 4 (August 1991): 161–66. http://dx.doi.org/10.1007/bf01957740.

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28

Strauss, Chris. "Methods and Principles in Medicinal Chemistry 25: Microwaves in Organic and Medicinal Chemistry. By C. Oliver Kappe and Alexander Stadler." ChemMedChem 1, no. 1 (January 16, 2006): 158–59. http://dx.doi.org/10.1002/cmdc.200500050.

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29

Differding, Edmond. "Trends in Drug Discovery over Five Decades – The European Federation for Medicinal Chemistry International Symposium on Medicinal Chemistry (EFMC−ISMC)." ChemMedChem 15, no. 24 (November 26, 2020): 2352–58. http://dx.doi.org/10.1002/cmdc.202000840.

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30

Talele, Tanaji. "Editorial [Medicinal Chemistry of Novel Therapeutics (Guest Editor: Tanaji Talele)]." Current Bioactive Compounds 4, no. 2 (August 1, 2008): 56. http://dx.doi.org/10.2174/157340708785294181.

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31

Guan, Xiangming. "Editorial of Virtual Special Issue on Progress in Medicinal Chemistry." Acta Pharmaceutica Sinica B 6, no. 5 (September 2016): 510–11. http://dx.doi.org/10.1016/j.apsb.2016.08.002.

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32

Tait, Annalisa. "Medicinal Chemistry in Parasitology: New Avenues in Drug Discovery." ChemMedChem 3, no. 3 (March 14, 2008): 409–11. http://dx.doi.org/10.1002/cmdc.200700184.

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33

Cristalli, Gloria, Péter Mátyus, Peter Mohr, Giuseppe Ronsisvalle, Noel J de Souza, and Anna Tsantili-Kakoulidou. "European Medicinal Chemistry Education: The Transformational Accomplishments and Challenges." ChemMedChem 3, no. 4 (April 14, 2008): 561–63. http://dx.doi.org/10.1002/cmdc.200700316.

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34

Brasili, Livio, Daniele Donati, and Luisa Mosti. "The XIXth National Meeting on Medicinal Chemistry: Verona, Italy." ChemMedChem 4, no. 6 (June 8, 2009): 899–904. http://dx.doi.org/10.1002/cmdc.200900168.

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35

Zettl, Heiko, Manfred Schubert-Zsilavecz, and Dieter Steinhilber. "Medicinal Chemistry of Incretin Mimetics and DPP-4 Inhibitors." ChemMedChem 5, no. 2 (February 1, 2010): 179–85. http://dx.doi.org/10.1002/cmdc.200900448.

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36

Giampietro, Letizia, Alessandra Ammazzalorso, Rosa Amoroso, and Barbara De Filippis. "Development of Fibrates as Important Scaffolds in Medicinal Chemistry." ChemMedChem 14, no. 11 (May 7, 2019): 1051–66. http://dx.doi.org/10.1002/cmdc.201900128.

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37

Ntoupa, Panagoula-Stamatina A., Ioannis I. Papoutsis, Artemisia A. Dona, Chara A. Spiliopoulou, and Sotiris A. Athanaselis. "A fluorine turns a medicinal benzodiazepine into NPS: the case of flualprazolam." Forensic Toxicology 39, no. 2 (February 2, 2021): 368–76. http://dx.doi.org/10.1007/s11419-020-00565-4.

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Abstract Purpose The purpose of this review is to summarize the existing knowledge on flualprazolam, a novel ‘designer’ benzodiazepine that derives from the fluorination of the phenyl moiety in the ortho-position of alprazolam. Methods An extensive literature search was carried out in PubMed, Google Scholar and World Wide Web using relevant keywords. All articles found were gathered, and the available information is presented. Results This article reviews the existing knowledge on chemistry, pharmacology, toxicology, prevalence and current legal status of flualprazolam. Moreover, forensic and clinical cases where flualprazolam was involved worldwide, as well as flualprazolam seizures, along with the methods for its determination in biological samples are presented. Conclusions The recent flualprazolam-related cases have raised concerns to regulatory authorities and international stakeholders suggesting that flualprazolam should be under international control. The urgent international control of flualprazolam, despite the limited information on clinical effects and pharmacologic characteristics available, is an important measure for the prevention of its increasing abuse worldwide.
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38

Brown, Stacy D. "A Process-Oriented Guided Inquiry Approach to Teaching Medicinal Chemistry." American Journal of Pharmaceutical Education 74, no. 7 (September 2010): 121. http://dx.doi.org/10.5688/aj7407121.

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39

Roche, Victoria F. "Antihyperlipidemic Statins: A Self-Contained, Clinically Relevant Medicinal Chemistry Lesson." American Journal of Pharmaceutical Education 69, no. 4 (September 2005): 77. http://dx.doi.org/10.5688/aj690477.

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40

Alsharif, Naser Z. "Medicinal Chemistry and Therapeutic Relevance of Angiotensin-Converting Enzyme Inhibitors." American Journal of Pharmaceutical Education 71, no. 6 (September 2007): 123. http://dx.doi.org/10.5688/aj7106123.

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41

Vincent, Omambia Mokoro, Joseph Mwanzia Nguta, Eric Simon Mitema, Fredrick Mutie Musila, Dorine Matara Nyak, Ali Hashim Mohammed, and Moriasi Apiri Gervason. "Ethnopharmacology, pharmacological activities, and chemistry of the Hypericum genus." Journal of Phytopharmacology 10, no. 2 (March 29, 2021): 105–13. http://dx.doi.org/10.31254/phyto.2021.10206.

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There are over 500 species in the Hypericum genus worldwide. Crude extracts from Hypericum species have been reported in folkloric medicine as analgesics, anthelmintics, astringents, antidepressants, diuretics, and anti-inflammatories. The current review aims to provide an in-depth analysis of local uses, pharmacological activities, and phytochemical composition of different extracts generated from Hypericum species. The review data was collected via literature search from Google, Google Scholar, Medline, Pubmed, Mendeley, Science Direct, Chemical Abstracts, Web of Science, and Scopus. The most studied of the entire Hypericum genus is H. perforatum, approved to manage mild depression. Other species that have been reported to have ethnomedicinal value are H. erectum, H. monogynum, H. attenuatum, H. japonicum, H. beanii, H. monantheum, H. wightianum, H. scabrum, H. monogynum, H. monogynum, H. geminiflorum, H. ascyron, H. seniawinii, H. elodeoides, H. petiolulatum, H. wightianum, H. hengshanense, H. japonicum, and H. revolutum. Over 900 phytochemicals have been isolated from the Hypericum genus plant species, mostly phenolics, and terpenoids. Studies have been carried out to validate the ethnopharmacological use of extracts from Hypericum species against depression, cancer, inflammation, and microbial infections. There are limited safety studies involving medicinal plants from the Hypericum genus; however,further investigations on toxic effects, phytochemical composition, and biological activities are necessary to validate the medicinal uses of plant species of the Hypericum genus empirically. The present article reviews ethnopharmacology, phytochemistry, and toxicology of the Hypericum genus, which several communities have used to treat various conditions.
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42

Smith, Chase, and Carolyn J. Friel. "Development and use of augmented reality models to teach medicinal chemistry." Currents in Pharmacy Teaching and Learning 13, no. 8 (August 2021): 1010–17. http://dx.doi.org/10.1016/j.cptl.2021.06.008.

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43

Krebs, Johanna, and Maureen McKeague. "Green Toxicology: Connecting Green Chemistry and Modern Toxicology." Chemical Research in Toxicology 33, no. 12 (November 20, 2020): 2919–31. http://dx.doi.org/10.1021/acs.chemrestox.0c00260.

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44

Cramer, Jörg, and Michael Berger. "European Medicinal Chemistry—Strategies, Targets, and Drugs under the Spotlight." ChemMedChem 1, no. 1 (January 16, 2006): 155–57. http://dx.doi.org/10.1002/cmdc.200500049.

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45

Hinzen, Berthold, Siegfried Raddatz, Holger Paulsen, Thomas Lampe, Andreas Schumacher, Dieter Häbich, Veronica Hellwig, et al. "Medicinal Chemistry Optimization of Acyldepsipeptides of the Enopeptin Class Antibiotics." ChemMedChem 1, no. 7 (July 10, 2006): 689–93. http://dx.doi.org/10.1002/cmdc.200600055.

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46

Veale, Clinton G. L., and Ronel Müller. "Recent Highlights in Anti‐infective Medicinal Chemistry from South Africa." ChemMedChem 15, no. 10 (April 9, 2020): 809–26. http://dx.doi.org/10.1002/cmdc.202000086.

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47

Felicetti, Tommaso, Giuseppe Manfroni, Violetta Cecchetti, and Rolando Cannalire. "Broad‐Spectrum Flavivirus Inhibitors: a Medicinal Chemistry Point of View." ChemMedChem 15, no. 24 (October 22, 2020): 2391–419. http://dx.doi.org/10.1002/cmdc.202000464.

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48

Gladysz, Rafaela, Anne-Marie Lambeir, Jurgen Joossens, Koen Augustyns, and Pieter Van der Veken. "Substrate Activity Screening (SAS) and Related Approaches in Medicinal Chemistry." ChemMedChem 11, no. 5 (February 4, 2016): 467–76. http://dx.doi.org/10.1002/cmdc.201500569.

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49

Veale, Clinton G. L. "Into the Fray! A Beginner's Guide to Medicinal Chemistry." ChemMedChem 16, no. 8 (February 16, 2021): 1199–225. http://dx.doi.org/10.1002/cmdc.202000929.

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50

Knaup, Fabian H., Christian Meyners, Anna Charalampidou, Patryk Krajczy, Patrick L. Purder, Tatjana Ross, and Felix Hausch. "Med Chem Remote: The Frontiers in Medicinal Chemistry 2021." ChemMedChem 16, no. 15 (June 7, 2021): 2411–16. http://dx.doi.org/10.1002/cmdc.202100355.

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