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Journal articles on the topic 'Toxicometric parameters'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Antonenko, A.M., O.P. Vavrinevych, S.T. Omelchuk, and B.I. Shpak. "Hygienic substantiation of calculating models for predicting toxicity of different classes insecticides (first part)." Medicni perspektivi 24, no. 3 (2019): 106–12. https://doi.org/10.26641/2307-0404.2019.3.181892.

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This work is the first part of our study to develop alternative experimental mathematic models for predicting toxicity of insecticides. In the first stage, calculations will be carried out and the most reliable models will be proposed. In the second – a statistical analysis and comparative estimation of the toxicometric parameters obtained experimentally and calculated according to the proposed equations. The purpose of the research is the scientific substantiation of the calculation models for predicting toxicity of insecticides of different classes. Data on the physico-chemical propert

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2

Komarova, E. F., E. V. Verenikina, N. A. Shevchenko, et al. "EVALUATION OF TOXICOMETRIC PARAMETERS OF BENZIMIDAZOLE DERIVATIVE FOR LINEAR MICE C57/BL6." Современные проблемы науки и образования (Modern Problems of Science and Education), no. 2 2023 (2023): 47. http://dx.doi.org/10.17513/spno.32499.

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3

Vavrinevych, O.P., B.I. Shpak, A.M. Antonenko, S.T. Omelchuk, and T.I. Zinchenko. "Hygienic substantiation of calculating models for prognosis of toxicity of different classes insecticides (second part)." Medicni perspektivi 25, no. 4 (2020): 166–73. https://doi.org/10.26641/2307-0404.2020.4.221663.

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This work is the second part of our study to develop alternative experimental mathematic models for predecting toxicity of insecticides, where we carried out a statistical analysis and comparative estimation of the toxicometric parameters obtained experimentally and calculated according to the proposed equations. In the first stage calculations were carried out and the most reliable models were proposed. The purpose of the research is the scientific substantiation and statistical analysis of the calculation models for predicting the toxicity of insecticides of different classes. For research w

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4

Epishina, Tatiana M. "Comparative studies of the toxicity of new synthetic detergents based on anionic and nonionic surface active substance." Toxicological Review 32, no. 5 (2024): 301–6. http://dx.doi.org/10.47470/0869-7922-2024-32-5-301-306.

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Introduction. Among the complex of environmental factors that are subject to toxicological and hygienic studies, household chemicals deserve great attention due to their mass production, a variety of components and formulations, as well as possible direct effects on the human body. The purpose of the work is to conduct comparative studies on the study of toxicometric parameters of new synthetic detergents. Material and methods. In accordance with the planned purpose of the study in the biological testing laboratory of the “Federal Scientific Center of Hygiene named after F.F. Erisman”, experim

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Novikova, O. N., E. S. Matyugina, A. V. Gorshenin, et al. "5'-Noraristeromycin Repurposing: Well-known S-Adenosyl-L-homocysteine Hydrolase Inhibitor As a Potential Drug Against Leukemia." Acta Naturae 16, no. 3 (2024): 60–66. http://dx.doi.org/10.32607/actanaturae.27443.

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5ˊ-Noraristeromycin as a racemic mixture of enantiomers was found to exhibit a pronounced cytotoxic effect on leukemia cells; IC50 for the Jurkat, K562, and THP-1 cell lines was 7.3, 1.3, and 3.7 μM, respectively. The general toxicity of 5'-noraristeromycin was studied in experiments on white mice upon single-dose intragastric administration; toxicometric parameters were determined, and the clinical and pathomorphological presentation of acute intoxication was studied. LD50 of the substance was shown to be 63.2 (52.7÷75.8) mg/kg; LD16, 44.7 mg/kg, and LD84, 89.4 mg/kg. Administration of the su

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6

Głowacki, Arkadiusz, Przemysław Rybiński, Monika Żelezik, and Ulugbek Zakirovich Mirkhodjaev. "Cage Nanofillers’ Influence on Fire Hazard and Toxic Gases Emitted during Thermal Decomposition of Polyurethane Foam." Polymers 16, no. 5 (2024): 645. http://dx.doi.org/10.3390/polym16050645.

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Polyurethane (PUR), as an engineering polymer, is widely used in many sectors of industries. However, the high fire risks associated with PUR, including the smoke density, a high heat release rate, and the toxicity of combustion products limit its applications in many fields. This paper presents the influence of silsesquioxane fillers, alone and in a synergistic system with halogen-free flame-retardant compounds, on reducing the fire hazard of polyurethane foams. The flammability of PUR composites was determined with the use of a pyrolysis combustion flow calorimeter (PCFC) and a cone calorime

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Khalilov, Laziz, and Yunus Salimov. "PARAMETERS OF ACUTE TOXICITY AND TOXIC EFFECTS OF THE SYNTHETIC PYRETHROID ASHIMETHRIN ALPHA ON THE ANIMAL BODY." INTERNATIONAL JOURNAL OF SCIENCE AND TECHNOLOGY 2, no. 05 (2025): 87–89. https://doi.org/10.70728/tech.v2.i05.030.

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The article presents the results of studying the acute toxicity of the synthetic pyrethroid ashimethrin alpha (Achich Life Science Put.Ltd., India) on the body of rabbits and Karakul sheep. To determine the main toxicometric parameters, experimental rabbits were given ashimethrin alpha orally once in the form of a 10% suspension at doses of 1300, 1375, 1450, 1525 and 1600 mg / kg, and Karakul sheep received doses of 200, 275, and 350 mg/kg (based on the active ingredient). Studies have established that LD50 for rabbits is 1450.00 mg/kg, and for sheep 347.79 mg/kg. Our observations showed that

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8

Antonova, O. M. "Promising approaches to assessing the public health risk with real ways of entering a toxicant into the body." Povolzhskiy Journal of Ecology, no. 4 (June 11, 2022): 371–84. http://dx.doi.org/10.35885/1684-7318-2021-4-371-384.

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The paper discusses promising directions of scientific and technological development of the Russian Federation in the field of ecology and nature management, and related problems and solutions for assessing the public health risk. The prospects of creating methods for rapid assessment of public health risk using modern data and representations of toxicokinetics and toxicodynamics of the substance are substantiated. It is shown that it is possible to deduce adequate mathematical dependencies for substances regardless of their structure, based on modern concepts of the formation of the dose of a

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9

Andreev, V. A., E. Yu Andreeva, L. P. Erdniyev, et al. "Using the Paramecium caudatum test object to determine acute toxicity of physiologically active substances." Bulletin of the Russian Military Medical Academy 21, no. 2 (2019): 110–13. http://dx.doi.org/10.17816/brmma25929.

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The advantage of biotesting in comparison with the physicochemical analysis of the use of Paramecium caudatum for toxicological studies has been shown. Physical and chemical analysis often fails to detect unstable compounds. In addition, these tools are not possible to determine the ultra-low concentration of chemicals. In addition to the traditional use of laboratory animals, representatives of protozoa have recently been used. In connection with this, a test object of the Sim-plest type was chosen and justified. The advantages of using the simplest compared with the use of laboratory animals

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10

Vostroilova, G. A., N. A. Khokhlova, Y. A. Chaplygina, and M. S. Bogdanova. "SAFETY ASSESSMENT OF THE NEW DRUG "MT-6" IN AN ACUTE EXPERIMENT ON WHITE MICE." Scientific Life 15, no. 5 (2020): 700–707. http://dx.doi.org/10.35679/1991-9476-2020-15-5-700-707.

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The article presents the results of assessing the safety of the new drug "MT-6" in an acute experiment on white mice. Experiments to assess acute toxicity were carried out in three series of experiments with intragastric, subcutaneous and intramuscular routes of administration in duplicate. The drug was administered intragastrically once after a 12-hour fasting diet in doses from 5500 to 10000 mg/kg in a volume of 0.5 ml per mouse; subcutaneously – in the dose range from 2000 to 6800 mg/kg in a volume of 0.5 ml per mouse; intramuscularly – in doses from 2000 to 6800 mg/kg in a volume of 0.25 m

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11

Dotsenko, Roman, Yevheniia Vashchyk, Andriy Zakhariev, Andrii Zemlianskyi, Ekaterina Dotsenko, and Nataliia Seliukova. "Determination of toxicological characteristics of a complex antiemeric drug based on maduramycin and nicarbazine." ScienceRise: Biological Science, no. 2(27) (June 30, 2021): 37–43. http://dx.doi.org/10.15587/2519-8025.2021.235941.

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The aim: to determine the parameters of acute toxicity of the preparative form of an antiemeric agent based on maduramycin and nicarbazine for white mice, white rats and guinea pigs with a single oral administration. Materials and methods. Determination of acute toxicity of the formulation by oral administration was performed on 48 adult male mice, 48 adult nonlinear male rats, 48 adult male guinea pigs. To conduct an experiment on the principle analogues were formed seven experimental and one control group, 6 animal each. The dose of the formulation was calculated individually based on

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12

Poghosyan, Susanna Babken, Natalya Stepan Tadevosyan, Susanna Arshavir Muradyan, Siranush Hovhannes Ter-Zakaryan, Ashot Norayr Jzhandzhapanyan, and Gayane Vladimir Kirakosyan. "Toxicological assessment of Capparis spinosa L. seed’s oil." Toxicological Review 29, no. 5 (2021): 58–63. http://dx.doi.org/10.36946/0869-7922-2021-29-5-58-63.

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Introduction. Herbal medicines are unique therapeutic agents that represent multicomponent complexes of biologically active substances. They have low toxicity, a wide spectrum of therapeutic action with a minimum of side effects and a relatively low cost. Capparis spinosa L. has been widely used in traditional medicine for the treatment of various diseases and health conditions. Material and methods. An assessment of the toxicometric parameters of Capparis spinosa L. seed’s oil was done by a single oral and dermal exposure, the average lethal doses have been calculated for both routes, sensiti

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13

Roman, Dotsenko, Vashchyk Yevheniia, Zakhariev Andriy, Zemlianskyi Andrii, Dotsenko Ekaterina, and Seliukova Nataliia. "Determination of toxicological characteristics of a complex antiemeric drug based on maduramycin and nicarbazine." ScienceRise: Biological Science, no. 2(27) (June 30, 2021): 37–43. https://doi.org/10.15587/2519-8025.2021.235941.

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<strong>The </strong><strong>aim:</strong> to determine the parameters of acute toxicity of the preparative form of an antiemeric agent based on maduramycin and nicarbazine for white mice, white rats and guinea pigs with a single oral administration. <strong>Materials and methods.</strong> Determination of acute toxicity of the formulation by oral administration was performed on 48 adult male mice, 48 adult nonlinear male rats, 48 adult male guinea pigs. To conduct an experiment on the principle analogues were formed seven experimental and one control group, 6 animal each. The d

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14

Kucherskoy, Semen Alexandrovich, Liliya Anatolievna Alikbaeva, Evgenii Yrievich Karmanov, Irina Borisovna Ermakova, Diana Gaevna Oskina, and Andrej Stanislavovich Radilov. "Experimental substantiation of the tentatively safe level of diethyl disulfide in the air of the working area and the atmospheric air of populated areas." Toxicological Review 30, no. 3 (2022): 177–81. http://dx.doi.org/10.47470/0869-7922-2022-30-3-177-181.

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Introduction. Diethyl disulfide belongs to the group of dialkyl disulfides, is a part of disulfide oil and a mixture of dialkyl disulfides. As a result of industrial purification of hydrocarbon raw materials from mercaptans, tens of thousands of tons of dialkyldisulfides and their mixtures are accumulated annually, the toxicity and danger of which have not been fully studied. No hygiene standards have been developed for diethyl disulfide. Materials and methods. Studies of the effects of diethyl disulfide were carried out in non-linear animals (rats and mice). The toxic properties of diethyl di

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15

Bagreev, Anton Yu, Valery N. Rakitskiy, Sergey V. Kuzmin, Daria I. Bagreeva, and Marina V. Vostrikova. "Toxicological characteristics of active ingredient of chlorosulfuron." Hygiene and sanitation 104, no. 5 (2025): 636–42. https://doi.org/10.47470/0016-9900-2025-104-5-636-642.

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Introduction. Herbicides have been one of the most effective weed control agents for many decades. They account for more than half of all registered pesticides. In the modern list of herbicides, more than a quarter of all active substances are compounds belonging to the class of sulfonylurea derivatives. Taking into account the specific aspects of the use of pesticides, the requirements for their toxicological and hygienic assessment are increasing every year. Among the promising drugs for the control of annual and some perennial weeds in the cultivation of grain crops, new combined products c

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16

Gorokhova, Larisa G., Nadezhda N. Mikhailova, Evgeniya V. Ulanova, and Tatyana K. Yadykina. "Assessment of the toxicity of benzoic acid derivatives in the intragastric intake." Hygiene and sanitation 99, no. 7 (2020): 755–60. http://dx.doi.org/10.47470/0016-9900-2020-99-7-755-760.

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Introduction. Benzoic acid and its numerous derivatives are widely used in all areas of chemical production. However, there is no information about the toxic properties of a large number of benzoic acid derivatives. The purpose of the study was to study the toxic properties of several derivatives of benzoic acids in intragastric intake in an experiment.Material and methods. The following derivatives of benzoic acid were studied: 4-chlorobenzoic, 4-methoxybenzoic, p-acetoxybenzoic and 2-methoxy-5-sulfamoylbenzoic acids. The studies were performed on white laboratory rats; toxicity was studied i

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17

Doronin, M. I., D. A. Lozovoy, V. V. Pronin, et al. "Miramistin effect on BHK-21 and PSGK-30 cell line proliferation and FMD virus reproduction in these cells." Veterinary Science Today, no. 1 (March 30, 2020): 17–24. http://dx.doi.org/10.29326/2304-196x-2020-1-32-17-24.

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At present, Miramistin drug (benzyldimethyl [3-(myristoylamino) propyl] ammonium chloride monohydrate), which has a broad bactericidal effect, is used in veterinary practice. This antiseptic is active against most viruses, mycoplasmas, bacteria, fungi and protozoa. According to toxicometric parameters, Miramistin is classified as a low-hazard substance. Use of cell structures as test systems for assessing the toxicity of pharmacological substances instead of conventional tests on experimental animals allows us to better clarify the possible mechanism of the effect of the investigated substance

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18

Pankratova, Galina P., Marina V. Bidevkina, and Zukhra К. Shaikhutdinova. "Safety of using disinfectants based on sodium hypochlorite in practice." Disinfection affairs, no. 1 (March 2023): 23–30. http://dx.doi.org/10.35411/2076-457x-2023-1-23-30.

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The parameters of toxicometry of disinfectants based on sodium hypochlorite obtained by chlorination of an aqueous solution of caustic soda (31 agents) and by electrochemical method – 10 anoliths were established. Based on the determination of the chlorine content in the air, recommendations are given for the safe use of these disinfectants: for surface treatment by wiping and disinfection of air and surfaces by aerosol spraying using a special device – an aerosol generator that provides dispersion of aerosol particles of 5–50 microns. A working solution of sodium hypochlorite with an active c

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19

Radilov, A. S., S. A. Solntseva, I. E. Shkaeva, et al. "EXPERIMENTAL SUBSTANTIATION OF THE MAXIMUM ALLOWABLE CONCENTRATION OF DIOCTYL TEREPHTHALATE IN THE AIR OF THE WORKING AREA." Toxicological Review, no. 1 (February 24, 2020): 34–38. http://dx.doi.org/10.36946/0869-7922-2020-1-34-38.

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Toxicity and hazard assessment of dioctyl terephthalate (DOTP) was performed in acute, subacute, and chronic experiments, and its principal toxicometry parameters were determined.It was found that on single exposure DOTP exhibits low toxicity and hazard. No resorptive and irritant effects on skin and mucous membrane of eyes were detected in animal experiments. The single inhalation exposure threshold limit value was set at 300 mg/m3, based on the results of monitoring of the functional state of the central nervous system and myocardium and hematological parameters.Thirty-day subacute experimen

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Rakitskiy, Valerii N., Elena G. Chkhvirkia, Darya I. Miroshnikova, Natalya N. Belyaeva, and Marina V. Vostrikova. "Actual problems of hygiene and toxicology of pesticides based on glyphosate." Hygiene and sanitation 101, no. 10 (2022): 1233–39. http://dx.doi.org/10.47470/0016-9900-2022-101-10-1233-1239.

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Introduction. For several decades, glyphosate has been one of the most widely used herbicides in the world, but the safety of glyphosate and its commercial formulations is still controversial. Materials and methods. The parameters of acute oral and dermal toxicity of glyphosate in rats have been established. An irritant effect on the skin and mucous membranes of the eyes (rats, rabbits), a sensitizing effect on guinea pigs were studied. To establish the degree of damaging effect on the body during its long-term administration, there was made a study of the chronic effect of glyphosate acid and

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Sheina, Natalia I., Marina V. Bidevkina, Margarita I. Golubeva, and Elena V. Budanova. "Improving approaches to hygienic rationing of antimicrobial drugs." Russian Journal of Occupational Health and Industrial Ecology 64, no. 4 (2024): 210–18. http://dx.doi.org/10.31089/1026-9428-2024-64-4-210-218.

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Introduction. Currently, the production of medicines, including those with antimicrobial properties, is expanding at chemical and pharmaceutical enterprises. However, scientific approaches to hygienic regulation of the content of specific antimicrobials in the air of the work area are not yet available. The study aims to substantiate approaches to predicting approximate safe levels of exposure (ASLE) to substances with a specific antimicrobial effect. Materials and methods. The scientists have carried out the research in two stages. The first stage is an experimental study of the single inhala

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Gorokhova, L. G., N. N. Mikhailova, A. G. Zhukova, and A. S. Kazitskaya. "Studies of the effect of indole and its derivative 1-benzylindole on the functional state of the heart and blood values of laboratory rats." Acta Biomedica Scientifica 9, no. 1 (2024): 64–72. http://dx.doi.org/10.29413/abs.2024-9.1.7.

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Background. Indole and its derivatives are widely used in all areas of pharmaceutical production. The toxicometry of indole compounds has been sufficiently studied. At the same time, there is still no information on the toxic effect on individual organs and systems during long-term intake of most compounds.The aim. To carry out an experimental study of the toxic effect of indole and its derivative 1-benzylindole on the functional state of the heart and blood values.Materials and methods. The work was carried out on 46 white rats, divided into groups: control group (n = 22); animals receiving i

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23

Nikolayeva, Natalia I., Andrey S. Filin, Ekaterina A. Guseva, and Lubov’ G. Ivanova. "The biological action of solid solutions (on the example of cadmium-mercury-tellurium alloy)." Health Care of the Russian Federation 64, no. 3 (2020): 158–62. http://dx.doi.org/10.46563/0044-197x-2020-64-3-158-162.

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Solid solutions are widely used in various industries. Experimental studies have been conducted to study the biological effects of warm-blooded animals (rat, mouse) solid solution based on cadmium (7%) mercury (52%) and tellurium (41%) (CMT). The purpose of the study: To investigate the biological effect of the solid solution (CMT) on the body of experimental animals. Material and methods. On the models of acute and subchronic exposure, the biological effect of CMT on the organism of warm-blooded animals (rats, mice) was evaluated. Studies have been carried out to establish toxicometry paramet

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Tonshin, Anton A., Tatiana A. Tkacheva, Svetlana V. Kautina, and Margarita I. Golubeva. "Development of new methods for predicting hygienic standards for the content of medicines in the air of the working area on the example of non-steroidal anti-inflammatory drugs." Russian Journal of Occupational Health and Industrial Ecology 63, no. 9 (2023): 574–85. http://dx.doi.org/10.31089/1026-9428-2023-63-9-574-585.

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Introduction. Experts predict the hygienic standards of medicines in Russia in accordance with the methods common to all medicines (MG 1.1.726-98), developed more than 25 years ago on the basis of experimental materials obtained during the rationing of 66 medicines. By 2023, the content of more than 230 medicines of various pharmacological orientation has already been normalized in the air of the working area. Such an array of experimental materials makes it possible to study the relationship between the values of standard toxicological and pharmacological indicators and hygienic standards app

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Klimov, V. I., O. S. Lalymenko, and L. V. Korsun. "Potential risks of occupational exposure to innovative biopharmaceuticals: a review." Extreme Medicine 26, no. 4 (2024): 74–81. https://doi.org/10.47183/mes.2024-26-4-74-81.

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Introduction. Gene-targeted therapies (gene-targeted, high-tech, and biopharmaceuticals) are developed based on active pharmaceutical ingredients, which are reactive compounds with pleiotropic activity. Such ingredients are associated with health hazards to workers employed at various stages of their production. Clinically significant pharmacological or toxicological effects of innovative medications on employees exposed to these components are unsafe from the perspective of a risk-based approach in occupational medicine.Objective. Assessment of potential risks of occupational exposure to inno

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26

Korshun, M. M., and Y. V. Martіianova. "ECOLOGICAL AND HYGIENIC ASSESSMENT OF NEW PESTICIDES FOR GRAIN CEREALS CHEMICAL PROTECTION." Medical Science of Ukraine (MSU) 17, no. 3 (2021): 85–92. http://dx.doi.org/10.32345/2664-4738.3.2021.09.

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Relevance. The use of pesticides in the national economy is to destroy or inhibit the growth of harmful plants and to protect crops from pathogens requires a mandatory assessment of their environmental hygienic hazard. Objective of our study is to assess the hazards of three new pesticides for cereal grains protection: amicarbazone from the chemical class of triazolinone compounds, bicyclopyrone from the class of tricetones and pydiflumetofen from the class of carboxamides, in terms of ecotoxicity and environmental behavior. Materials and methods. Hazard assessment of amicarbazone,

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Kayutina, Svetlana V., Anton A. Tonshin, Elena A. Karpukhina, et al. "Toxicological and hygienic assessment of calcium dinitrate: justification of the maximum permissible concentration in the air of the working area." Russian Journal of Occupational Health and Industrial Ecology 64, no. 11 (2024): 713–21. http://dx.doi.org/10.31089/1026-9428-2024-64-11-713-721.

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Introduction. The article tells about the widespread use of calcium nitrate (calcium nitrate, anhydrous calcium nitrate, calcium salt of nitric acid), about the use in the production of additives to concrete, deicing reagents, detergents, fertilizers and in other fields of human activity. There are data in the literature on the toxicity and danger of compounds similar in chemical structure, there is an approved maximum permissible concentration of calcium dinitrate in the atmospheric air of urban and rural settlements equal to 0.03 mg/m3 — the maximum single and 0.01 mg/m3 — the average daily

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Shyshkin, I. O., V. Yu Anisimov, A. V. Nikitin, and V. O. Gelmboldt. "ACUTE TOXICITY OF OCTENIDINE HEXAFLUOROSILICATE." Odes’kij medičnij žurnal (The Odessa Medical Journal), no. 5 (2021). http://dx.doi.org/10.54229/2226-2008-2021-5-3.

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The aim of the work. Determination of toxicometric characteristics of octenidine hexafluorosilicate (OHFS), characterized by significant pharmaceutical potential, in an acute experiment on rats by oral administration. Materials and Methods. A study of the acute toxicity of octenidine hexafluorosilicate was carry out on 42 male Wistar rats weighing 180–200 grams. The main criterion for quantifying the toxicity of octenidine hexafluorosilicate was LD50, which was determined using the least squares method. In addition, the following hazard indicators were calculated: 1/LD50 – median lethal dose (

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Anna, Antonenko, and Vavrinevych Olena. "DEVELOPMENT AND HYGIENIC SUBSTANTIATION OF CALCULATING MODELS FOR PROGNOSIS OF PYRAZOLECARBOXAMIDES, CARBOXAMIDES, TRIAZOLES, CARBAMATES CLASSES OF FUNGICIDES TOXICITY DEPEND ON THEIR PHYSICAL AND CHEMICAL PROPERTIES." October 31, 2017. https://doi.org/10.21303/2585-663.2017.00441.

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Methods for determining the toxicological parameters of pesticides are long-term, labor-intensive and require significant financial and resource costs, which is why laboratories do not always cope with the increasing flow of chemical plant protection products. In solving this problem, the important role is played by methods of mathematical modeling and prediction of xenobiotics toxicity. <strong>The </strong>aim of the research is the scientific substantiation of the possibility of creating and using of calculation models for predicting the toxicity of various classes of fungicides. <stro

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Yakubov, Khayot Khamidullaevich Kadirov Kuralbay Urazbayevich Otakulov Sohibjon Ismatillaevich. "FORENSIC TOXICOMETRY AND TANATOGENESIS IN ACUTE COMBINED POISONINGS." May 1, 2024. https://doi.org/10.5281/zenodo.11098445.

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<em>The nosology of acute poisoning is extremely diverse and differs significantly in different countries. In Uzbekistan, the bulk of poisoning is accounted for by alcohol and its surrogates, acids (mainly acetic) and alkalis, various medications, mainly hypnotics and sedatives, organophosphorus and other pesticides. The biological activity of chemical compounds is determined by their structure, physical and chemical properties, dose (concentration) and duration of exposure; features of intake and biotransformation in the body; resistance of tissues and organs to poisons and the individual cha

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E.K., Vlasenko, Gapanovich V.N., Vasilyeva E.N., et al. "TOXICOLOGICAL CHARACTERISTICS, HAZARD CLASSIFICATION AND SUBSTANTIATION OF MAXIMUM PERMISSIBLE CONCENTRATIONS OF THE PHARMACEUTICAL SUBSTANCE OF METFORMIN HYDROCHLORIDE IN THE AIR OF THE WORKING AREA AND ATMOSPHERE." Medical Journal, 2022, 39–46. http://dx.doi.org/10.51922/1818-426x.2022.4.39.

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A toxicological and hygienic assessment of the pharmaceutical substance of metformin hydrochloride was performed using various regimens, doses and ways of entry into the body of laboratory animals. The conducted studies allowed us to establish the parameters of the toxicometry of metformin and the features of its biological action, which consist in the absence of an irritating effect on the skin and skin-resorptive properties, an allergenic effect on the body and weak cumulative properties and irritant effect on the mucous membranes of the eyes. Hazard classes of the metformin hydrochloride an

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Kucherskoy, SA, and LA Alikbaeva. "In vivo toxicity study of dialkyl disulphides." Medicine of Extreme Situations, no. (2)2021 (June 2021). http://dx.doi.org/10.47183/mes.2021.015.

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As a result of the industrial purification of hydrocarbons from mercaptans, tens of thousands of tons of dialkyl disulphides and their mixtures, the toxicity and hazard of which has not been fully understood, are accumulated annually. The exposure standards have been developed only for dimethyl disulphide. The study was aimed to define toxicometry parameters for diethyl disulphide, disulphide oil, and the mixture of dialkyl disulphides. Toxicology studies involving male outbred rats made it possible to define the median lethal doses and concentrations: diethyl disulphide — after intragastric i

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Mykola, Kondratiuk, and Blagaia Anna. "TOXICOLOGICAL ASSESSMENT OF COMBINED FUNGICIDES PROPOSED FOR APPLICATION ON CEREAL SPIKED CROPS IN UKRAINE." October 31, 2017. https://doi.org/10.21303/2585-663.2017.00442.

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Toxicological assessment of combined fungicides proposed for application on cereal spiked crops in Ukraine was performed according approved State Sanitary Norms and Rules. Statistics, bibliographical methods were used in the study. The classes of hazard were established after evaluation of toxicometry parameters, which included assessment of acute oral toxicity, acute dermal toxicity, acute inhalation toxicity, irritation potential to eyes (mucous membranes) and skin, and sensitizing properties. Integral hazard class of the studied formulations was established. Formulations<strong> </stro

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Avdeeva, E. Yu, M. G. Skorokhodova, V. V. Sheikin, T. V. Kadyrova, and M. V. Belousov. "Technology of dry extract from the <i>Filipendula ulmaria</i> (L.) Maxim. and preliminary assessment of its safety profile." Drug development & registration, May 3, 2024. http://dx.doi.org/10.33380/2305-2066-2024-13-2-1682.

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Introduction. Medicines of natural origin have advantages over synthetic drugs and occupy a significant share in the assortment of pharmacies. Filipendula ulmaria (L.) Maxim., characterized by a chemical composition rich in phenolic compounds and various types of biological activity has the potential in terms of the development of new herbal medicines. In an in vivo experiment, F. ulmaria extract showed immunomodulatory, anti-inflammatory, osteogenic activity and effectively stimulated myelopoiesis in conditions of microbial damage of bone tissue.Aim. Development of an optimal technology for o

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