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Dissertations / Theses on the topic 'Toxin'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Javid-Khojasteh, Vahideh. "Toxic Shock Syndrome Toxin-1 : detection of the toxin, anti-toxin antibodies and producer organisms in a paediatric burns unit." Thesis, University of Salford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365993.

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2

Guttenberg, Gregor [Verfasser], and Manfred [Akademischer Betreuer] Jung. "Clostridiale Glukosylierende Toxine: Untersuchungen zur Autoprozessierung von Clostridium sordellii Letalem Toxin und Clostridium novyi alpha-Toxin sowie funktionelle Charakterisierung von Clostridium perfringens TpeL-Toxin." Freiburg : Universität, 2012. http://d-nb.info/1123467994/34.

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3

Maldonado-Arocho, Francisco J. "Characterization of host-pathogen interaction of two bacterial toxins anthrax edema toxin and Escherichia coli cytolethal distending toxin /." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1973060671&sid=4&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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4

Fernandes, da Costa Sérgio Paulo. "Molecular and structural characterisation of epsilon toxin and necrotic enteritis toxin B : two pore-forming toxins from Clostridium perfringens." Thesis, University of Exeter, 2013. http://hdl.handle.net/10871/14608.

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Epsilon toxin (Etx) and necrotic enteritis toxin B (NetB) are two pore-forming toxins produced by C. perfringens. While Etx has been shown to be the key virulence factor for enterotoxemia in goats and sheep, NetB has been associated with the pathogenesis of avian necrotic enteritis (NE), a gastro-intestinal disease causing economic damage to the poultry industry worldwide. The crystal structure of Etx H149A (an Etx variant with 6x reduced toxicity relative to wild type toxin) was solved to 2.4 Å and showed that the H149A mutation in domain III does not affect organization of the receptor bindi

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5

Hovey, Bianca T. "Cholera toxin and heat-labile enterotoxin : structural studies of assembly and design of active A-subunit constructs /." Thesis, Connect to this title online; UW restricted, 2000. http://hdl.handle.net/1773/9263.

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6

Edwards-Jones, Valerie. "Toxic shock syndrome toxin production in relation to burned patients." Thesis, University of Salford, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244871.

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7

Kuk, Chiu Ying. "Anthrax Lethal Toxin Is a Tumor Hemorragic Toxin." Thesis, Van Andel Research Institute, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10973827.

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<p> Blood supply is crucial for tumor growth and metastasis. However, current anti-angiogenic therapy is not as effective as predicted, thus a better understanding of the tumor angiogenic process and new anti-angiogenic agent are urgently required. Anthrax lethal toxin (LeTx) has an anti-angiogenic effect on tumors. Tumors treated with LeTx are smaller, paler, and have lower mean vessel density compared to control treated tumors. Most interestingly, compared to current anti-angiogenic treatment, LeTx does not cause normalization of tumor vessels. Instead, tumors treated with LeTx have massive

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8

Pellino, Christine A. "Characterization of Shiga Toxin Potency and Assembly." University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1418909563.

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9

Penha, Marcelo De Luca. "Detecção dos genes das toxinas alfa, beta e épsilon de Clostridium perfringens isolados a partir de amostras clínicas de bovinos pela reação em cadeia da polimerase." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/10/10134/tde-06072005-101119/.

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O Clostridium perfringens é um microrganismo anaeróbio que está presente no solo e no trato intestinal dos mamíferos. Provoca intoxicação alimentar nos seres humanos, doenças enterotoxêmicas nos animais domésticos e gangrena gasosa em ambos os grupos. O C. perfringens é classificado em cinco tipos (A, B, C, D e E) mediante a produção de quatro toxinas principais (alfa, beta, épsilon e iota). Neste trabalho foi possível padronizar a técnica de PCR para detectar a presença dos genes cpa, cpb e etx a partir de culturas de C. perfringens. A sensibilidade analítica da técnica de PCR a partir de cul

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10

Rosten, Patricia Melanie. "The role of toxic shock syndrome toxin-1 in the pathogenesis of toxic shock syndrome." Thesis, University of British Columbia, 1986. http://hdl.handle.net/2429/26527.

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Toxic shock syndrome toxin-1 (TSST-1), an exoprotein produced by some strains of Staphylococcus aureus, is implicated in the pathogenesis of menstrual TSS. However, its role in nonmenstrual TSS is less certain. In order to study the pathogenetic role of TSST-1 in TSS, three approaches were taken: a) to develop an ELISA for detection of TSST-1 in biologic fluids in order to verify TSST-1 production in vivo in TSS patients, b) to quantitate TSST-1 specific antibodies in the serum of TSS patients and controls to determine whether such antibodies are protective, and c) to attempt to identify other

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11

Massey, Christopher. "Cellular and Molecular Mechanisms of Toxin Resistance For Endoplasmic Reticulum Translocating Toxins." Master's thesis, University of Central Florida, 2009. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2687.

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The endoplasmic reticulum (ER) is the site of co- and post-translational modification for secretory proteins. In order to prevent vesicular transport and secretion of misfolded or misassembled proteins, a highly regulated mechanism called ER-associated degradation (ERAD) is employed. This pathway recognizes misfolded proteins in the ER lumen and targets them to the cytosol for ubiquitination and subsequent degradation via the 26S proteasome. Sec61 and Derlin-1 are ER pores through which export occurs. AB-type protein toxins such as cholera toxin (CT), Shiga toxin (ST), exotoxin A (ETA), and ri

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12

Wilczek, Claudia. "Identifizierung des zellulären Rezeptors für das binäre Toxin von Clostridium spiroforme." Doctoral thesis, Universitätsbibliothek Leipzig, 2015. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-166768.

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Erst kürzlich wurde der Lipolyse-stimulierte Lipoproteinrezeptor (LSR, engl. lipolysis-stimulated lipoprotein receptor) als der zelluläre Oberflächenrezeptor von CDT und Iota-Toxin, zweier Vertreter der Iota-Toxin-Familie der clostridialen Aktin-ADP-ribosylierenden Toxine, identifiziert. In dieser Arbeit sollte geprüft werden, ob CST, ein weiterer Vertreter der Iota-Toxin-Familie, ebenfalls LSR für den Zelleintritt nutzt. Zunächst wurden die Toxinkomponenten CSTa und CSTb erstmals rekombinant hergestellt. Dazu wurden die für CSTa und CSTb codierenden Genabschnitte mittels PCR amplifiziert und

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13

Pigatto, Caroline Peters [UNESP]. "Carcaterização denotípica e genotípica de Escerichia coli produtora de toxina shiga (STEC) isoladas de bovinos de corte no Estado do Paraná." Universidade Estadual Paulista (UNESP), 2008. http://hdl.handle.net/11449/103826.

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Made available in DSpace on 2014-06-11T19:32:52Z (GMT). No. of bitstreams: 0 Previous issue date: 2008-01-29Bitstream added on 2014-06-13T20:44:10Z : No. of bitstreams: 1 pigatto_cp_dr_jabo.pdf: 841661 bytes, checksum: 288fcbc74e176eac0befc1827d1bc15e (MD5)<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)<br>Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)<br>Escherichia coli produtoras de toxina Shiga (STEC) são reconhecidas como agentes causadores de infecções em humanos em todo o mundo. O principal reservatório é o bovino. Neste trabalho, cepas de STEC p

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14

Passalacqua, Edward F. "X-ray crystallographic studies of toxic shock syndrome toxin-1 and related superantigens." Thesis, University of Bath, 1995. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295442.

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15

Leka, Oneda. "Structural and functional characterization of A-B toxins: diphtheria toxin and clostridial neurotoxins." Doctoral thesis, Università degli studi di Padova, 2016. http://hdl.handle.net/11577/3421803.

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I performed my doctorate research activity studying three important human pathogens that are A-B toxins: Diphtheria Toxin (DT), Tetanus Neurotoxin (TeNT) and Botulinum neurotoxins (BoNTs), the etiologic agents of diphtheria, tetanus and botulism respectively. In terms of structural organization these toxins consist of three domains, which are termed L chain (the N-terminal catalytic domain), HN (the transmembrane domain), and HC (the C-terminal binding domain). These domains are closely related to the common four step mechanism of action: membrane binding mediated by HC, endocytosis, membrane

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16

Bader, Carly. "The cytopathic activity of cholera toxin requires a threshold quantity of cytosolic toxin." Master's thesis, University of Central Florida, 2013. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/5762.

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Cholera toxin (CT), secreted from Vibrio cholerae, causes a massive fluid and electrolyte efflux in the small intestine that results in life-threatening diarrhea and dehydration which impacts 3-5 million people per year. CT is secreted into the intestinal lumen but acts within the cytosol of intestinal epithelial cells. CT is an AB5 toxin that has a catalytic A1 subunit and a cell binding B subunit. CT moves from the cell surface to the endoplasmic reticulum (ER) by retrograde transport. Much of the toxin is transported to the lysosomes for degradation, but a secondary pool of toxin is diverte

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17

Gao, Haifei. "Chemical biology approaches to study toxin clustering and lipids reorganization in Shiga toxin endocytosis." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB147.

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La toxine bactérienne de Shiga se lie au glycosphingolipide (GSL) globotriaosylcéramide (Gb3) afin d’entrer par endocytose dans les cellules en utilisant une voie dépendante et indépendante de la clathrine. Dans la voie indépendante de la clathrine, la toxine de Shiga réorganise les lipides de la membrane de façon à imposer une contrainte mécanique sur la bicouche, conduisant ainsi à la formation de pic d’invagination d'endocytose profonds et étroits. Mécaniquement ce phénomène n’est pas encore compris, notamment il reste énigmatique, comment se traduisent les propriétés géométriques de l’agré

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18

Karlsson, Sture. "Toxin production in Clostridium difficile /." Stockholm : Karolinska institutet, 2004. http://diss.kib.ki.se/2004/91-77349-812-2/.

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19

Strack, Julia [Verfasser], and Andreas [Akademischer Betreuer] Bechthold. "Osteoklastendifferenzierung durch Pasteurella multocida-Toxin." Freiburg : Universität, 2014. http://d-nb.info/1123480834/34.

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20

Sharma, Davinder Kumar. "Toxin production by Clostridium botulinum." Thesis, University of East Anglia, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301991.

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The endopeptidase activity assay developed for measurement of purified botulinum neurotoxin type A (BoNT/A) in clinical therapeutic preparations has been adopted to provide a specific measure of BoNT/A activity in culture supernatants of proteolytic C. botulinum type A. Electrophoretic studies and inhibition of BoNT/A activity by anti-A antibody confirmed the specificity of the assay. The minimum detection limit was 0.2 MLD50/ml indicating the assay as more sensitive than the standard mouse bioassay or any other in vitro assay available to date. Whilst the assay did not exhibit any cross react

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21

Díaz, Ocaña Raquel. "Recombinant self-assembling nanoparticles for cancer therapy based on toxin and venom compounds." Doctoral thesis, Universitat Autònoma de Barcelona, 2020. http://hdl.handle.net/10803/670483.

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La plataforma desenvolupada d’enginyeria de proteïnes auto-acoblables permet dissenyar nanopartícules únicament proteiques (NPs) capaces d’atacar i actuar selectivament sobre les cèl.lules canceroses mitjançant la interacció amb receptors que es sobreexpressen. Les estructures esfèriques estables de les NPs desenvolupades i la seva mida adequada, en combinació amb els pèptids d’orientació , milloren la seva especificitat. A més, la incorporació de segments de toxina i verí ha millorat els efectes terapèutics d’aquestes estructures que són totalment biocompatibles i que no tenen cap portador ex

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22

Zimmermann, Leigh A. "Environmental regulation of toxin production : comparison of hemolytic activity of Amphidinium carterae and Amphidinium klebsii /." Electronic version (PDF), 2006. http://dl.uncw.edu/etd/2006/zimmermannl/leighzimmermann.pdf.

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23

Trescos, Yannick. "Effets des toxines de Bacillus anthracis sur le cytosquelette des cellules immunitaires : implication sur la phagocytose et les fonctions immunitaires." Thesis, Université Grenoble Alpes (ComUE), 2015. http://www.theses.fr/2015GREAV026/document.

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Bacillus anthracis, agent de la maladie du charbon, est aussi un agent majeur de la menace biologique. Sa virulence est liée à deux principaux facteurs : une capsule et deux toxines, la toxine oedémateuse (ET = EF + PA) et la toxine létale (LT = LF + PA). EF est une adénylate cyclase, calcium et calmoduline dépendante, produisant une élévation de la concentration en AMPc intracellulaire tandis que LF est une métalloprotéase à zinc clivant la majorité des Mitogen Activated Protein Kinase Kinases. Les toxines jouent un rôle central dans la pathogénie de la maladie du charbon et dans la dérégulat

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24

Rystedt, Alma. "Botulinum Toxin : Formulation, Concentration and Treatment." Doctoral thesis, Uppsala universitet, Neurologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-181667.

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Botulinum toxin (BTX) is used in various fields of medicine, including the treatment of hyperhidrosis and cervical dystonia. Botox®, Dysport®, Xeomin® and NeuroBloc® are commercially available BTX products, which are formulated differently and their dosing units are unique. Dosage and concentration of the prepared solution for injection varies considerably among studies comparing the products. Improved guidelines on concentration and dosing when changing from one product to another are warranted. This would ensure the use of the lowest effective doses for good effect, minimal risk of antibody

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25

Taft, Sarah C. "Anthrax toxin immunity and receptor activity /." Cincinnati, Ohio : University of Cincinnati, 2007. http://www.ohiolink.edu/etd/view.cgi?ucin1195584188.

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Thesis (Ph.D.)--University of Cincinnati, 2007.<br>Advisor: Alison A. Weiss. Title from electronic thesis title page (viewed Feb. 5, 2008). Keywords: Bacillus anthracis, anthrax toxin, AVA. Includes abstract. Includes bibliographical references.

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26

Chatwell, Nicola. "Nucleic acid approaches to toxin detection." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.606582.

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PCR is commonly used for detecting contamination of foods by toxigenic bacteria. However, it is unknown whether it is suitable for detecting toxins in samples which are unlikely to contain bacterial cells, such as purified biological weapons. Quantitative real-time PCR assays were developed for amplification of the genes encoding Clostridium botulinum neurotoxins A to F, Staphylococcal enteroxin B (SEB), ricin, and C. perfringens alpha toxin. Botulinum neurotoxins, alpha toxin, ricin and V antigen from Yersinia pestis were purified at Dstl using methods including precipitation, ion exchange, F

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27

Promdonkoy, Boonhiang. "Molecular biology of a microbial toxin." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621541.

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28

Martínez-García, Juan Carlos. "Expression cloning of insecticidal toxin receptors." Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.621840.

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29

Bergmann, Stefan [Verfasser], and Klaus [Akademischer Betreuer] Aktories. "Charakterisierung zytotoxischer Pasteurella multocida-Toxin–Chimären." Freiburg : Universität, 2015. http://d-nb.info/1114996289/34.

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30

TAFT, SARAH C. "ANTHRAX TOXIN: IMMUNITY AND RECEPTOR ACTIVITY." University of Cincinnati / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1195584188.

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31

Tallett, April. "Structure and function of pertussis toxin." Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/20238.

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32

Tan, Yian Kim. "Novel functions of anthrax lethal toxin." Fairfax, VA : George Mason University, 2009. http://hdl.handle.net/1920/3451.

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Thesis (Ph.D.)--George Mason University, 2009.<br>Vita: p. 141. Thesis director: Charles Bailey. Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biodefense. Title from PDF t.p. (viewed June 10, 2009). Includes bibliographical references (p. 110-140). Also issued in print.

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33

MacMaster, Kayleigh A. "Characterization of Cellular Pathways and Potency of Shiga Toxin on Endothelial Cells." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439304438.

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34

Michaelides, Alecos. "Chemical and enzymatic fragmentation of tetanus toxin and immunological studies on anti-tetanus toxin and toxoid sera." Thesis, University of Ottawa (Canada), 1996. http://hdl.handle.net/10393/9661.

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This thesis describes the immunization protocols for the production of antibodies against tetanus toxin and toxoid in guinea pigs and mice. Antibodies were successfully raised against the toxin without mortalities in either species. The murine sera obtained, were isotyped by ELISA and the toxin was proven to be a superior antigen in eliciting production of IgG$\rm\sb{2a}$ and IgG$\sb3$. The two isotypes which have demonstrated antitumor activity. The anti-toxoid sera exhibited a lower reactivity towards the toxin and toxoid when compared with anti-toxin sera. The reactivity of recombinant teta

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35

Hostetter, Shannon Jones. "Role of Shiga toxin dissemination and inflammation in the pathogenesis of Shiga toxin-producing Escherichia coli infection." [Ames, Iowa : Iowa State University], 2009.

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36

SANTOS, Danilo Mamede da Silva. "Detecção de Microcystis potencialmente tóxicas em reservatórios de Pernambuco, através de marcadores moleculares para o operon da sintetase da microcistina - mcyB e mcyA." Universidade Federal Rural de Pernambuco, 2008. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/4757.

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Submitted by (edna.saturno@ufrpe.br) on 2016-06-15T14:42:00Z No. of bitstreams: 1 Danilo Mamede da Silva Santos.pdf: 1106435 bytes, checksum: ca64d8b9517455ac26cf78c379fd9c5e (MD5)<br>Made available in DSpace on 2016-06-15T14:42:00Z (GMT). No. of bitstreams: 1 Danilo Mamede da Silva Santos.pdf: 1106435 bytes, checksum: ca64d8b9517455ac26cf78c379fd9c5e (MD5) Previous issue date: 2008-02-14<br>Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq<br>Cyanobacterias or cyanoficeas, even they have many similarities with eukariotics seaweed and occupy the same ambie

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37

Herrera, Alfa. "Staphylococcus aureus TSST-1 and Beta-toxin contribute to infective endocarditis via multiple mechanisms." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/5775.

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Staphylococcus aureus is a gram positive bacterium asymptomatically colonizing 30-40% of the human population. S. aureus causes a variety of infections including superficial skin lesions, toxic shock syndrome, and infective endocarditis (IE). There are 100,000 cases of IE each year in the United States. IE is a life threatening infection of native/prosthetic valves and the lining of the heart. It is characterized by the formation of vegetations, “cauliflower-like” structures composed of bacteria and host factors. S. aureus is the most commonly identified pathogen (up to 40%) in patients with I

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38

Taylor, J. M. Walsh. "Identification and isolation of emetic toxin producing Bacillus Cereus and heat-stable toxins from other Bacillus species." Thesis, Glasgow Caledonian University, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.415442.

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39

Daimon, Yasushi. "Activation of Toxin-Antitoxin System Toxins Suppresses Lethality Caused by the Loss of σE in Escherichia coli". Kyoto University, 2016. http://hdl.handle.net/2433/215457.

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40

Leeper, Molly Maitland. "Trends in Toxin Profiles of Human Shiga Toxin-Producing Escherichia Coli (STEC) O157 Strains, United States, 1996-2008." Atlanta, Ga. : Georgia State University, 2009. http://digitalarchive.gsu.edu/iph_theses/57/.

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Thesis (M.P.H.)--Georgia State University, 2009.<br>Title from file title page (Digital Archive@GSU, viewed June 16, 2010) Karen Giseker, committee chair; Peter Gerner-Smidt, committee member. Includes bibliographical references (p. 101-105).

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41

Blower, Timothy Robert. "Functional and structural studies of the toxIN abortive infection and toxin-antitoxin locus from Erwinia carotovora subspecies atroseptica." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608655.

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42

Kerzmann, Amy N. "Mechanistic analysis of Clostridium difficile toxin A." [Bloomington, Ind.] : Indiana University, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3378359.

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Thesis (Ph.D.)--Indiana University, Dept. of Biology, 2009.<br>Title from home page (viewed on Jul 12, 2010). Source: Dissertation Abstracts International, Volume: 70-10, Section: B, page: 6182. Advisers: Andrew L. Feig; James T. Drummond.

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43

Li, Feng. "Studies on inhibition against anthrax lethal toxin." Oklahoma City : [s.n.], 2010.

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44

Adams, Toni Elizabeth. "Bordetella bronchiseptica dermonecrotic toxin, purification and characterisation." Thesis, University of Leicester, 1997. http://hdl.handle.net/2381/29723.

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Dermonecrotic toxin (DNT) is produced by all the Bordetella species, and DNT from B. bronchiseptica is considered to be an important virulence factor in turbinate atrophy of pigs.;Recombinant DNT (rDNT) was purified by sonication, ion-exchange and hydroxylapatite chromatography. Other methods for the purification of wild-type DNT and rDNT, including preparative isoelectric focusing and hydrophobic chromatography, were investigated in detail.;Partially pure preparations of rDNT contained a 145 kDa protein band and were cytotoxic to embryonic bovine lung (EBL) cells. Partially pure rDNT induced

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45

Rizzolo, Flavio. "ToXin, an indexing scheme for XML data." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58778.pdf.

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46

Hayes, Edward. "Fragment based design of cholera toxin inhibitors." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.534749.

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47

Rooks, David John. "Molecular ecology of shiga-toxin encoding bacteriophage." Thesis, University of Liverpool, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.548790.

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48

Schmidt, Elke. "Structure-function characterisation of zonula occludens toxin." Thesis, University of Strathclyde, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.501858.

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49

Eames, Niall W. A. "Botulinim toxin A and gastrocnemius muscle length." Thesis, Queen's University Belfast, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.387872.

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50

Smyth, Martin Gerard. "Structural characterization of the pasteurella multocida toxin." Thesis, Birkbeck (University of London), 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338390.

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