Relevant bibliographies by topics / Toxine

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Toxine'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 January 2023

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Journal articles on the topic "Toxine"

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Suaad Abid Fazaa ALmiyah. "Frequency of exofoliative toxine genes among staphylococcus aureus isolated from burn infection patients in the Specialized Centre for burns of Al – Diwaniyah city." Journal of Pharmaceutical Negative Results 13, no. 4 (2022): 814–19. http://dx.doi.org/10.47750/pnr.2022.13.04.109.

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Background: Exfoliative toxins (ETs) of bacterium Staphylococcus aureus are the main cause of infections in skin burns. This research sought to determine the frequency of the eta(exofoliative toxine A) gene, etb(exofoliative toxine B) gene and etd(exofpliative toxine D) gene in the S. aureus..Methods: Between January 2021 and December 2021, 155 S. aureus isolates were gathered from burn sample patients at the Al-Diwaniyah Specialized Burns Center. The polymerase chain reaction was utilized to identify the eta gene , etb gene and etd gene found in the isolates after the species had been establi
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Russmann, H. "Toxine." Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 46, no. 11 (2003): 989–96. http://dx.doi.org/10.1007/s00103-003-0716-0.

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Veres, Claude. "Toxine botulique." EMC - Cosmétologie et dermatologie esthétique 1, no. 1 (2006): 1–4. http://dx.doi.org/10.1016/s1283-0143(06)75102-0.

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Chatin, B. "Toxine botulique." Annales de Chirurgie Plastique Esthétique 49, no. 1 (2004): 47–48. http://dx.doi.org/10.1016/j.anplas.2003.12.005.

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Siproudhis, L. "Toxine botulique." Côlon & Rectum 5, no. 2 (2011): 96–97. http://dx.doi.org/10.1007/s11725-011-0300-y.

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Groß, Michael. "Protein-Toxine." Nachrichten aus der Chemie 51, no. 7-8 (2003): 830–31. http://dx.doi.org/10.1002/nadc.20030510715.

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Parnas, J. "Toxine der Leptospiren." Zentralblatt für Veterinärmedizin Reihe B 18, no. 8 (2010): 596–603. http://dx.doi.org/10.1111/j.1439-0450.1971.tb01663.x.

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Perrier, Jean-Jacques. "Toxine contre cancer." Biofutur 2000, no. 205 (2000): 13. http://dx.doi.org/10.1016/s0294-3506(01)80016-8.

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Ben Smaïl, D., P. Denys, and B. Bussel. "Toxine botulique et paraplégie." Annales de Réadaptation et de Médecine Physique 46, no. 6 (2003): 296–98. http://dx.doi.org/10.1016/s0168-6054(03)00101-6.

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Simon, O., P. Raibaut, M. Faucher, S. Sheik-Ismael, and G. Amarenco. "Toxine botulique et céphalées." Annales de Réadaptation et de Médecine Physique 46, no. 6 (2003): 312–18. http://dx.doi.org/10.1016/s0168-6054(03)00104-1.

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Dissertations / Theses on the topic "Toxine"

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Keller, Laurence. "L'utilisation therapeutique des toxines bacteriennes : exemples de la toxine botulinique et de la toxine diphterique." Strasbourg 1, 1994. http://www.theses.fr/1994STR15056.

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Perelle, Sylvie. "Toxine IOTA de "Clostridium perfringens" et toxines apparentées." Paris 11, 1996. http://www.theses.fr/1996PA114811.

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Kaddari, Fatiha. "Conformations et activités ionophores de toxines cyclotétrapeptidiques HC toxine et tentoxine /." Grenoble 2 : ANRT, 1987. http://catalogue.bnf.fr/ark:/12148/cb37606224c.

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Goeders, Nathalie. "Diversité des systèmes toxine-antitoxine bactérien de type II." Doctoral thesis, Universite Libre de Bruxelles, 2014. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209291.

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Les systèmes toxine-antitoxine (TA) sont composés d’une toxine intracellulaire qui cible un processus cellulaire essentiel et qui est neutralisée par une antitoxine. Ces systèmes sont très abondant chez les bactéries et sont impliqués dans la réponse aux stress, la formation de biofilm, le phénomène de persistance, etc.<p>Mon projet de thèse a porté sur l’étude de la diversité des systèmes TA à deux niveaux. Dans un premier temps, plusieurs toxines de la famille RelE provenant de différentes espèces bactériennes et associées à des antitoxines non-canoniques ont été étudiées. Dans la seconde pa
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Guglielmini, Julien. "Origine et évolution des systèmes toxine-antitoxine de classe II." Doctoral thesis, Universite Libre de Bruxelles, 2010. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/210148.

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Les systèmes toxine-antitoxine (TA) sont composés de deux gènes organisés en opéron retrouvés chez la quasi-totalité des bactéries ainsi que chez les archées. Ils ont été découverts sur des plasmides, où ils induisent une tuerie post-segregationnelle (PSK). En effet, l’antitoxine est instable car elle est dégradée par une protéase ATP dépendante. Lors de la réplication, si un plasmide portant un système TA n’est pas transmis à la cellule fille, celle-ci recevra tout de même une partie du cytoplasme de la cellule mère qui contenait des protéines de toxine et d’antitoxine. Cette dernière étant i
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Aullo, Patricia. "Toxines chimériques dérivées de la toxine diphtérique : application en biologie cellulaire et thérapeutique." Paris 7, 1992. http://www.theses.fr/1992PA077008.

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La toxine diphtérique, avec la mise en œuvre par génie génétique de toxines chimériques, est devenue un outil polyvalent. Nous avons réalisé deux types de toxines chimériques dérivées de la toxine diphtérique, l'une présente un intérêt thérapeutique important pour l'éradication des infections par le VIH (virus de l'immunodéficience humaine), l'autre constitue un outil pour l'analyse de la régulation de l'actine par la petite protéine-G rho.
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Geeraerts, Damien. "Diversité et évolution des systèmes toxine-antitoxine bactériens de classe II." Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209762.

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Les systèmes toxine-antitoxine sont divisés en trois classes suivant la nature et le mode d’action de l’antitoxine. Ils sont fortement représentés au sein du règne bactérien et se trouvent sur des éléments génétiques mobiles qu’ils stabilisent dans la population bactérienne, mais aussi sur les chromosomes bactériens où leur fonction n’a pas encore été établie avec certitude. Au cours de ce travail, nous avons étudié les systèmes toxine-antitoxine bactériens de classe II, qui sont généralement composés de deux gènes organisés en opéron. Le premier gène code pour une antitoxine qui antagonise l’
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El, Hage Tatiana. "Rôle du compartiment endosomal dans la cytotoxicité de trois toxines hétérodimériques AB : la toxine diphtérique, l'exotoxine A de pseudomonas aeruginosa et la toxine du choléra." Paris 11, 2010. http://www.theses.fr/2010PA114838.

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Les toxines AB sont des toxines hétérodimériques d’origine bactérienne ou végétale constituées de deux sous unités: la sous-unité B liante qui permet l’interaction de la toxine avec la cellule infectée ; et la sous-unité A catalytique qui exerce l’activité cytotoxique. Les toxines AB natives sont synthétisées sous la forme dimérique inactive et requiert au moins un clivage protéolytique et/ou réductionnel par des systèmes enzymatiques cellulaires afin de libérer la sous-unité catalytique A sous la forme monomérique cytotoxique. Afin d’atteindre leur cible protéique localisée dans le compartime
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Mansour, Moïse. "Mécanisme moléculaire des systèmes toxine-antitoxines de M. tuberculosis." Thesis, Toulouse 3, 2019. http://www.theses.fr/2019TOU30251.

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Les systèmes de toxines-antitoxines (TA) bactériens de type II sont des éléments sensibles au stress composés d'une toxine et d’une antitoxine capable d’inhiber l’action de la toxine. Les deux partenaires sont présents sur le même opéron qui est généralement autorégulé par l'antitoxine et/ou le complexe toxine-antitoxine. Sous certaines conditions de stress, l'antitoxine est dégradée par les protéases et la toxine active peut alors cibler certains processus cellulaires importants, comme la réplication de l'ADN, la synthèse de la paroi, la division cellulaire ou la traduction, entraînant ainsi
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Beaufrere, Laurent. "Traitement par la toxine botulique : application en ophtalmologie." Montpellier 1, 1992. http://www.theses.fr/1992MON11201.

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Books on the topic "Toxine"

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Toxine. Abimo, 2007.

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Robin, Cook. Toxine. Éd. France loisirs, 2000.

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Manuel de détoxication: Santé et vitalité par l'élimination des toxines. Ed. Jouvence, 1990.

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Schallehn, G. Beiträge zur Isolierung und Identifizierung von Clostridium sp. und Bacillus sp. sowie zum Nachweis deren Toxine. Bundesamt für Zivilschutz, 1998.

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Levert, Myriam. Évaluation de la disfluidité de la dysphonie spasmodique avant et après injection de toxine botulique. Programme de maîtrise en orthophonie, Université Laurentienne, 1999.

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Foster, Helen. Detox solutions: 14 plans to detox your life. Select Publications, 2003.

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Phan, Văn Chi. Trichobakin và Immunotoxin tái tổ hợp. Nhà xuất bản Khoa học tự nhiên và công nghệ, 2008.

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Botulinum neurotoxins. Springer, 2013.

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Joseph, Jankovic, ed. Botulinum toxin: Therapeutic clinical practice & science. Saunders/Elsevier, 2008.

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Gluckstein, Fritz P. Clinical use of botulinum toxin: January 1987 through September 1990, 318 citations. U.S. Dept. of Health and Human Services, Public Health Service, National Institutes of Health, National Library of Medicine, Reference Section, 1990.

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Book chapters on the topic "Toxine"

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Fürnsinn, Gerhard. "Toxine." In Der biologisch-chemische Katastrophenfall. Springer Vienna, 2001. http://dx.doi.org/10.1007/978-3-7091-3742-0_6.

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Niehaus-Osterloh, Monika, and Claudia Mainka. "Bakterielle Toxine." In Toxikologie. Springer Berlin Heidelberg, 2017. http://dx.doi.org/10.1007/978-3-662-55265-0_8.

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Schrader, Adolf, Otfried Strubelt, Gustav Wagner, and Folker Amelung. "Bakterielle Toxine." In Toxisch bedingte Krankheiten des Nervensystems. Springer Berlin Heidelberg, 1992. http://dx.doi.org/10.1007/978-3-642-76898-9_15.

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Fritsch, Peter. "Erytheme durch bakterielle Toxine." In Fortschritte der praktischen Dermatologie und Venerologie. Springer Berlin Heidelberg, 2001. http://dx.doi.org/10.1007/978-3-642-56437-6_73.

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Elsner, Peter. "Exfoliative Toxine und Hauterkrankungen." In Fortschritte der praktischen Dermatologie und Venerologie. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-48223-6_67.

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Schurch, B., and G. Karsenty. "Les injections de toxine botulinique." In Les incontinences urinaires de l’homme. Springer Paris, 2011. http://dx.doi.org/10.1007/978-2-287-99160-8_28.

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Wätjen, Wim. "Natürlich vorkommende Toxine in Lebensmitteln." In Ernährung - Physiologische und Praktische Grundlagen. Springer Berlin Heidelberg, 2021. http://dx.doi.org/10.1007/978-3-662-61667-3_14.

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Bhakdi, S. "Schädigung von Zellen durch porenbildende bakterielle Toxine." In Bakterien, Endotoxin, Sepsis — Immunglobulin M. Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-70794-0_5.

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Luther, Peter, and Hans Becker. "Lektine und Toxine aus Viscum album L. (Mistel)." In Die Mistel. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71257-9_4.

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Kallinowski, Friedrich, M. Hofmann, A. Wassmer, J. Heesemann, HJ Buhr, and C. Herfarth. "Prävalenz enteropathogener Bakterien und Toxine bei operationspflichtigen chronisch entzündlichen Darmerkrankungen." In Chirurgisches Forum ’95 für experimentelle und klinische Forschung. Springer Berlin Heidelberg, 1995. http://dx.doi.org/10.1007/978-3-642-79621-0_134.

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Conference papers on the topic "Toxine"

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Pöhlmann, C., T. Elßner, and R. Wörl. "Paralleler Nachweis biologischer Toxine mit einer elektrochemischen Detektionsplattform." In 10. Dresdner Sensor-Symposium 2011. Forschungsgesellschaft für Messtechnik, Sensorik und Medizintechnik e.V. Dresden, 2011. http://dx.doi.org/10.5162/10dss2011/7.2.

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Dichtelmuller, H., and W. Stephan. "IN VIVO AND IN VITRO NEUTRALIZATION OF BACTERIAL TOXINES BY IGM ENRICHED AND CONVENTIONAL I. V. IMMUNOGLOBULINS." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644255.

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Severe septic phenomena are caused bybacterial toxins. We therefore investigated the neutralization of toxins derived from Staphylococcus aureus and Pseudcmonas aeruginosa by different i.v. irtmunoglobulin preparations using hemolysis inhibition tests and mouse protection tests. The efficacy of conventional i.v. immunoglobulin containing preparations were compared with an IgM enriched i.v. immunoglobulin (Pentaglobin).For hemolysis inhibition tests sterile filtered supernatant of Staphylococcusaureus was prepared and given to human erythrocytes. When IgM enriched immunoglobulin was added, toxi
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Sicard, L., A. B. Kaddour, D. O'Hana, and R. Khonsari. "Luxation bilatérale de l’articulation temporo-mandibulaire chez l’enfant." In 66ème Congrès de la SFCO. EDP Sciences, 2020. http://dx.doi.org/10.1051/sfco/20206602015.

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La luxation bilatérale non-traumatique de l’articulation temporo-mandibulaire est une pathologie aiguë qui peut évoluer vers la chronicité ou la récurrence. Chez l’enfant, peu de cas ont été rapportés dans la littérature et aucun protocole de prise en charge globale n’a été proposé à ce jour. 2 cas de luxation chronique de l’articulation temporo-mandibulaire chez le jeune enfant sont décrits et leur prise en charge discutée au vue des données issues de la littérature. Lors de la prise en charge de la phase aiguë, le protocole de sédation doit être particulièrement adapté au degré de coopératio
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Gomes, Maria Clara Cavalcante, Nathaly Bruna de Oliveira Silva, João Lucas Pessoa de Vasconcelos, Saulo Brivaldo Mendonça da Silva, Mariana Souza Bezerra Cavalcanti, and Ana Bárbara Xavier da Silva. "USO DA TOXINA BOTULÍNICA COMO TERAPIA COADJUVANTE EM PACIENTES COM DOENÇA DE PARKINSON, DISFUNÇÕES TEMPOROMANDIBULARES E BRUXISMO." In XXVII Semana de Biomedicina Inovação e Ciência. Editora IME, 2021. http://dx.doi.org/10.51161/9786588884119/46.

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Introdução: A toxina botulínica é uma neurotoxina produzida pelo Clostridium botulinum, causador do botulismo, doença neuroparalítica grave(1,3). Esta, é uma proteinase de zinco que realiza a clivagem de proteínas associadas a vesículas neuronais, responsáveis pela liberação de acetilcolina na junção neuromuscular(1). A doença de Parkinson (DP), afeta significativamente a vida dos pacientes, alguns não respondem às opções terapêuticas aplicadas costumeiramente, prejudicando ainda mais essa situação(2). Ademais, disfunções temporomandibulares (DTMs) e bruxismo do sono (BS), são condições que pr
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Taylor, Graham, Donald Leo, and Andy Sarles. "Detection of Botulinum Neurotoxin/A Insertion Using an Encapsulated Interface Bilayer." In ASME 2012 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/smasis2012-8101.

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Many signaling mechanisms in living cells occur at biological boundaries via cell surface receptors and membrane proteins embedded in lipid bilayers. The coordination of actions of sensory and motor neurons in the nervous system represents one example of many that heavily depends on lipid membrane bound receptor mediated signaling. As a result, chemical and biological toxins that disrupt these neural signals can have severe physiological effects, including paralysis and death. Botulinum neurotoxin Type A (BoNT/A) is a proteolytic toxin that inserts through vesicle membranes and cleaves membran
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Assis, Luana, Marcus Gomez та Célio Junior. "Synergistic attenuation of cancer-related pain and implications on adverse effects by the use of methadone and Phα1β in C57BL/6J mice". У 1st International Electronic Conference on Toxins. MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09158.

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Castano-Duque, Lina, Brian Mack, Matthew Gilbert, Christine Sickler, Jeffrey Cary, and Kanniah Rajasekaran. "Flavonoids play a key role in resistance to accumulation of aflatoxin in corn." In 1st International Electronic Conference on Toxins. MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09131.

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Sanchez, Elda, Emelyn Salazar, Kassandra Rodriguez, and Montamas Suntravat. "Biological characterization of a Kunitz-type inhibitor from the Malaysian King cobra (<em>Ophiophagus hannah</em>) venom." In 1st International Electronic Conference on Toxins. MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09144.

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Tonello, Fiorella, and Caterina Peggion. "<em>In silico</em> analysis of short linear motifs present in snake venom phospholipases A2." In 1st International Electronic Conference on Toxins. MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09137.

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Kiseleva, Mariya, Zakhar Chalyy, and Irina Sedova. "Herbal tea: transfer of mycotoxins from matrix into infusion." In 1st International Electronic Conference on Toxins. MDPI, 2021. http://dx.doi.org/10.3390/iect2021-09159.

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Reports on the topic "Toxine"

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Gurevitz, Michael, Michael E. Adams, Boaz Shaanan, et al. Interacting Domains of Anti-Insect Scorpion Toxins and their Sodium Channel Binding Sites: Structure, Cooperative Interactions with Agrochemicals, and Application. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7585190.bard.

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Integrated pest management in modern crop protection may combine chemical and biological insecticides, particularly due to the risks to the environment and livestock arising from the massive use of non-selective chemicals. Thus, there is a need for safer alternatives, which target insects more specifically. Scorpions produce anti-insect selective polypeptide toxins that are biodegradable and non-toxic to warm-blooded animals. Therefore, integration of these substances into insect pest control strategies is of major importance. Moreover, clarification of the molecular basis of this selectivity
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Mevarech, Moshe, Jeremy Bruenn, and Yigal Koltin. Virus Encoded Toxin of the Corn Smut Ustilago Maydis - Isolation of Receptors and Mapping Functional Domains. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7613022.bard.

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Ustilago maydis is a fungal pathogen of maize. Some strains of U. maydis encode secreted polypeptide toxins capable of killing other susceptible strains of U. maydis. Resistance to the toxins is conferred by recessive nuclear genes. The toxins are encoded by genomic segments of resident double-strande RNA viruses. The best characterized toxin, KP6, is composed of two polypeptides, a and b, which are not covalently linked. It is encoded by P6M2 dsRNA, which has been cloned, sequenced and expressed in a variety of systems. In this study we have shown that the toxin acts on the membranes of sensi
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Gurevitz, Michael, Michael E. Adams, and Boaz Shaanan. Structural Elements and Neuropharmacological Features Involved in the Insecticidal Properties of an Alpha Scorpion Neurotoxin: A Multidisciplinary Approach. United States Department of Agriculture, 1995. http://dx.doi.org/10.32747/1995.7573061.bard.

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Integrated pest management in modern crop protection requires the use of chemical or biological insecticides in many instances. Nontheless, the use non-selective chemical insecticides poses risks to the environment and livestock and consequently urgent need exists for safer alternatives, which target insects more specifically. Scorpions produce anti-insect selective polypeptide toxins that are biodegradable and not toxic to wam-blooded animals. Therefore, mobilization of these substances into insect pest targets is of major interest. Moreover, clarification of the molecular basis of this selec
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Gurevitz, Michael, Michael Adams, and Eliahu Zlotkin. Insect Specific Alpha Neurotoxins from Scorpion Venoms: Mode of Action and Structure-Function Relationships. United States Department of Agriculture, 1996. http://dx.doi.org/10.32747/1996.7613029.bard.

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This study was motivated by the need to develop new means and approaches to the design of future, environmentally-safe, insecticides. Utilization of anti-insect selective toxins from scorpion venoms and clarification of the molecular basis for their specificity, are a major focus in this project and may have an applicative value. Our study concentrated on the highly insecticidal toxin, LqhaIT, and was devoted to: (I) Characterization of the neuropharmacological and electrophysiological features of this toxin. (II) Establishment of a genetic system for studying structure/activity relationships
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Gurevitz, Michael, William A. Catterall, and Dalia Gordon. Learning from Nature How to Design Anti-insect Selective Pesticides - Clarification of the Interacting Face between Insecticidal Toxins and their Na-channel Receptors. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7697101.bard.

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Structural details on the interacting faces of toxins and sodium channels (Navs), and particularly identification of elements that confer specificity for insects, are difficult to approach and require suitable experimental systems. Therefore, natural toxins capable of differential recognition of insect and mammalian Navs are valuable leads for design of selective compounds in insect control. We have characterized several scorpion toxins that vary in preference for insect and mammalian Navs, and identified residues important for their action. However, despite many efforts worldwide, only little
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Gordon, Dalia, Ke Dong, and Michael Gurevitz. Unexpected Specificity of a Sea Anemone Small Toxin for Insect Na-channels and its Synergic Effects with Various Insecticidal Ligands: A New Model to Mimic. United States Department of Agriculture, 2010. http://dx.doi.org/10.32747/2010.7697114.bard.

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Motivated by the high risks to the environment and human health imposed by the current overuse of chemical insecticides we offer an alternative approach for the design of highly active insect-selective compounds that will be based on the ability of natural toxins to differentiate between insect and mammalian targets. We wish to unravel the interacting surfaces of insect selective toxins with their receptor sites on voltage-gated sodium channels. In this proposal we put forward two recent observations that may expedite the development of a new generation of insect killers that mimic the highly
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Wisniewski, Michael, Samir Droby, John Norelli, Dov Prusky, and Vera Hershkovitz. Genetic and transcriptomic analysis of postharvest decay resistance in Malus sieversii and the identification of pathogenicity effectors in Penicillium expansum. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7597928.bard.

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Use of Lqh2 mutants (produced at TAU) and rNav1.2a mutants (produced at the US side) for identifying receptor site-3: Based on the fact that binding of scorpion alpha-toxins is voltage-dependent, which suggests toxin binding at the mobile voltage-sensing region, we analyzed which of the toxin bioactive domains (Core-domain or NC-domain) interacts with the DIV Gating-module of rNav1.2a. This analysis was based on the assumption that the dissociation of toxin mutants upon depolarization would vary from that of the unmodified toxin should the substitutions affect a site of interaction with the ch
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8

Chejanovsky, Nor, and Bruce D. Hammock. Enhancement of Baculoviruses' Insecticidal Potency by Expression of Synergistic Anti-Insect Scorpion Toxins. United States Department of Agriculture, 1996. http://dx.doi.org/10.32747/1996.7573070.bard.

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The extensive use or non-specific, hazardous, chemical insecticides demands the development of "healthier" alternative means for pest control. Insect-specific, baculoviruses expressing anti-insect toxin genes (from mites or scorpions) demonstrated in laboratory assays and field trials enhanced insecticidal activity and provided some protection from lepidopterous larvae to agricultural plantations. To utilize recombinant baculoviruses as commercial biopesticides in row crop agriculture, further increase in their speed of kill should be achieved and the reduction in crop damage should be compara
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9

Chejanovsky, Nor, Bruce D. Hammock, Eliahu Zlotkin, and Michael Gurevitz. Dually Functional Recombinant Baculovirus Expressing Both the Excitatory and Depressant Insect Selective Neurotoxins. United States Department of Agriculture, 1993. http://dx.doi.org/10.32747/1993.7568101.bard.

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The present project is aimed to improve the insecticidal potency of baculoviruses, to American and Israeli lepidopterous pests of Spodoptera and Heliothis species, by engineering recombinant baculoviruses expressing anti-insect toxins derived from scorpion venom. Through this study were isolated recombinant Autographa california M Nucleopolyhedroviruses (AcNPVs) which expressed alpha (LqhaIT), excitatory (AaIT, LqhIT1 and LqhIT3) and depressant (LqhIT2) anti-insect neurotoxins. Bioassays on Heliothis species (Helicoverpa armigera and Heliothis virescens) were employed to assess the potency of
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10

Gurevitz, Michael, William A. Catterall, and Dalia Gordon. face of interaction of anti-insect selective toxins with receptor site-3 on voltage-gated sodium channels as a platform for design of novel selective insecticides. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699857.bard.

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Voltage-gated sodium channels (Navs) play a pivotal role in excitability and are a prime target of insecticides like pyrethroids. Yet, these insecticides are non-specific due to conservation of Navs in animals, raising risks to the environment and humans. Moreover, insecticide overuse leads to resistance buildup among insect pests, which increases misuse and risks. This sad reality demands novel, more selective, insect killers whose alternative use would avoid or reduce this pressure. As highly selective insect toxins exist in venomous animals, why not exploit this gift of nature and harness t
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