Relevant bibliographies by topics / TPGS

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
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Academic literature on the topic 'TPGS'

Author: Grafiati
Published: 4 June 2021
Last updated: 3 February 2022

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Journal articles on the topic "TPGS"

1

Zuccari, Guendalina, Sara Baldassari, Silvana Alfei, Barbara Marengo, Giulia Elda Valenti, Cinzia Domenicotti, Giorgia Ailuno, Carla Villa, Leonardo Marchitto, and Gabriele Caviglioli. "D-α-Tocopherol-Based Micelles for Successful Encapsulation of Retinoic Acid." Pharmaceuticals 14, no. 3 (March 4, 2021): 212. http://dx.doi.org/10.3390/ph14030212.

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All-trans-retinoic acid (ATRA) represents the first-choice treatment for several skin diseases, including epithelial skin cancer and acne. However, ATRA’s cutaneous side effects, like redness and peeling, and its high instability limit its efficacy. To address these drawbacks and to improve ATRA solubilization, we prepared ATRA-loaded micelles (ATRA-TPGSs), by its encapsulation in D-α-tocopheryl-polyethylene-glycol-succinate (TPGS). First, to explore the feasibility of the project, a solubility study based on the equilibrium method was performed; then, six ATRA-TPGS formulations were prepared by the solvent-casting method using different TPGS amounts. ATRA-TPGSs showed small sizes (11–20 nm), low polydispersity, slightly negative zeta potential, and proved good encapsulation efficiency, confirmed by a chemometric-assisted Fourier transform infrared spectroscopy (FTIR) investigation. ATRA-TPGS stability was also investigated to choose the most stable formulation. Using Carbopol® 980 as gelling agent, ATRA-TPGS-loaded gels were obtained and analyzed for their rheological profiles. Ex vivo release studies from ATRA-TPGSs were performed by Franz cells, demonstrating a permeation after 24 h of 22 ± 4 µ cm−2. ATRA-TPGSs showed enhanced cytotoxic effects on melanoma cells, suggesting that these formulations may represent a valid alternative to improve patient compliance and to achieve more efficacious therapeutic outcomes.
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Zuccari, Guendalina, Silvana Alfei, Alessia Zorzoli, Danilo Marimpietri, Federica Turrini, Sara Baldassari, Leonardo Marchitto, and Gabriele Caviglioli. "Increased Water-Solubility and Maintained Antioxidant Power of Resveratrol by Its Encapsulation in Vitamin E TPGS Micelles: A Potential Nutritional Supplement for Chronic Liver Disease." Pharmaceutics 13, no. 8 (July 23, 2021): 1128. http://dx.doi.org/10.3390/pharmaceutics13081128.

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Children affected by chronic liver disease exhibit impaired neurocognitive development and growth due to the low absorption and digestion of nutrients. Furthermore, malnutrition is an adverse prognostic factor in liver transplantation as it is associated with an increase in morbidity and mortality. D-α-tocopheryl-polyethylene-glycol-succinate (TPGS) is currently administered per os as a vitamin E source to improve children’s survival and well-being; however, TPGS alone does not reverse spinocerebellar degeneration and lipid peroxidation. To potentiate the effects of TPGS, we loaded micelles with resveratrol (RES), a natural polyphenol, with antioxidant and antiinflammatory activities, which has demonstrated protective action in the liver. Firstly, we investigated the suitability of TPGS to encapsulate RES in micelles by means of a phase-solubility study, then RES-TPGS formulations were prepared via solvent casting and solvent diffusion evaporation methods. RES-TPGS colloidal dispersions showed small mean diameters (12 nm), low polydispersity, and quite neutral Zeta potentials. The formulations showed a sustained drug release and a good drug loading capacity, further confirmed by infrared spectroscopy and differential scanning calorimetry. RES-TPGSs exhibited unaltered antioxidant activity compared to pristine RES via the DPPH assay and a significant reduction in toxicity compared to empty TPGS on HaCaT cells. Thus, RES-TPGS micelles may overcome the challenges of current liver disease therapy by providing more protective effects thanks to the antioxidant activity of RES and by reducing the surfactant toxicity on normal cells.
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Jia, Shuxin, Shaochen Wang, Shanshan Li, Peng Hu, Shuling Yu, Jiahua Shi, and Jintao Yuan. "Specific modification and self-transport of porphyrins and their multi-mechanism cooperative antitumor studies." Journal of Materials Chemistry B 9, no. 14 (2021): 3180–91. http://dx.doi.org/10.1039/d0tb02847a.

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The introduction of TPGS increases the cellular uptake and antitumor activity of TAPP-TPGS. TAPP-TPGS/PTX with small size increases the enrichment of drug and photosensitizer in tumor region and has excellent biocompatibility and synergistic treatment effect of TPGS, chemotherapy and PDT.
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ZHAO, TIEJUN, HEZHONG CHEN, LIXIN YANG, HAI JIN, ZHIGANG LI, LIN HAN, FANGLIN LU, and ZHIYUN XU. "DDAB-MODIFIED TPGS-b-(PCL-ran-PGA) NANOPARTICLES AS ORAL ANTICANCER DRUG CARRIER FOR LUNG CANCER CHEMOTHERAPY." Nano 08, no. 02 (April 2013): 1350014. http://dx.doi.org/10.1142/s1793292013500148.

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Oral chemotherapy is a great way to cancer treatment because it is less stressful being that the patient will have less hospital visits and can still maintain a close relationship with health care professionals. In this research, three types of nanoparticle formulation from commercial PCL and self-synthesized TPGS-b-(PCL-ran-PGA) diblock copolymer were fabricated for oral delivery of antitumor agents, including DDAB-modified PCL nanoparticles, unmodified TPGS-b-(PCL-ran-PGA) nanoparticles and DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles. Firstly, the TPGS-b-(PCL-ran-PGA) diblock copolymer was synthesized and characterized. DDAB was adopted to increase retention time at the cell surface, thus increasing the chances of nanoparticle uptake by the gastrointestinal mucosa and improving drug absorption. The TPGS-b-(PCL-ran-PGA) nanoparticles were found by FESEM of spherical shape and around 200 nm in diameter. The surface charge of TPGS-b-(PCL-ran-PGA) nanoparticles was reversed from anionic to cationic after DDAB modification. The DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles have significantly higher level of the cell uptake than that of DDAB-modified PCL nanoparticles and unmodified TPGS-b-(PCL-ran-PGA) nanoparticles. In vitro cell viability studies showed advantages of the DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticles over Taxotere® in terms of cytotoxicity against A549 cells. In conclusion, oral chemotherapy by DDAB-modified TPGS-b-(PCL-ran-PGA) nanoparticle formulation may provide a promising outcome for lung cancer patients.
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Liu, Tengfei, Xiaoyan Liu, Hui Xiong, Cheng Xu, Jianxu Yao, Xiumei Zhu, Jianping Zhou, and Jing Yao. "Mechanisms of TPGS and its derivatives inhibiting P-glycoprotein efflux pump and application for reversing multidrug resistance in hepatocellular carcinoma." Polymer Chemistry 9, no. 14 (2018): 1827–39. http://dx.doi.org/10.1039/c8py00344k.

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Ji, Suping, Xiao Lin, Enjiang Yu, Chengyang Dian, Xiong Yan, Liangyao Li, Meimei Zhang, Wenchang Zhao, and Linghui Dian. "Curcumin-Loaded Mixed Micelles: Preparation, Characterization, and In Vitro Antitumor Activity." Journal of Nanotechnology 2018 (2018): 1–9. http://dx.doi.org/10.1155/2018/9103120.

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The objective of this study was to prepare curcumin-loaded mixed Soluplus/TPGS micelles (Cur-TPGS-PMs) for oral administration. The Cur-TPGS-PMs showed a mean size of 65.54 ± 2.57 nm, drug encapsulation efficiency over 85%, and drug loading of 8.17%. The Cur-TPGS-PMs were found to be stable in various pH media (pH 1.2 for 2 h, pH 6.8 for 2 h, and pH 7.4 for 6 h). The X-ray diffraction (XRD) patterns illustrated that curcumin was in the amorphous or molecular state within PMs. The In vitro release test indicated that Cur-TPGS-PMs possessed a significant sustained-release property. The cell viability in MCF-7 cells was found to be relatively lower in Cur-TPGS-PM-treated cells as compared to free Cur-treated cells. CLSM imaging revealed that mixed micelles were efficiently absorbed into the cytoplasm region of MCF-7 cells. Therefore, Cur-TPGS-PMs could have the significant value for the chronic breast cancer therapy.
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Ji, Li Li, Qiao Ling Li, Zeng Hu Yang, Wei Jing Hu, and Kui Hua Zhang. "Fabrication and Characterization of Vitamin E TPGS Loaded Silk Fibroin/Hyaluronic Acid Nanofibrous Scaffolds." Advanced Materials Research 721 (July 2013): 274–77. http://dx.doi.org/10.4028/www.scientific.net/amr.721.274.

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Vitamin E d-alpha-tocopheryl polyethylene glycol 1000 succinate (VE TPGS) loaded silk fibroin (SF)/ hyaluronic acid (HA) nanofibrous scaffolds were fabricated by means of electrospinning to biomimic the natural extracellular matrix. Scanning electronic microscopy (SEM) results indicated that electrospun VE TPGS loaded SF/HA nanofibers were ribbon-shaped, the width of nanofibers decreased slightly with the addition of VE TPGS to SF/HA blended solutions. Fourier transform infrared (FTIR) spectroscopy and Wide-angle X-ray diffraction (WAXD) curves revealed that VE TPGS did not induce SF conformation from random coil to β-sheet. SF conformation converted from random coil to β-sheet after being treated with 75% ethanol vapor. In vitro release studies confirmed VE TPGS had no obvious burst release and present good release behavior.
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Wang, Hai Long, Shan Kui Liu, Yao Yao Qin, and Yun Gang Chen. "Hydroxycamptothecin Stealth Liposomes: Containing TPGS as a Novel PEGylated Long-Circulating Coating Material." Advanced Materials Research 886 (January 2014): 333–36. http://dx.doi.org/10.4028/www.scientific.net/amr.886.333.

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The goal of this study was to develop long-circulating liposomes of hydroxylcamptothecin (HCPT) with TPGS as a new coating material. Liposomes were prepared by a thin-film dispersion method with the lipids comprised phosphatidylcholine, cholesterol and TPGS. By contrast, other common PEGylated derivatives were also involved. HCPT-loaded liposomes with TPGS as coating material showed similar physicochemical characteristics andin vitrorelease profile to liposomes with DSPE-PEG or DPPE-PEG. It is suggested that TPGS can be applied as a novel coating material for long-circulating liposomes.
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Yusuf, Osman, Raisuddin Ali, Abdullah H. Alomrani, Aws Alshamsan, Abdullah K. Alshememry, Abdulaziz M. Almalik, Afsaneh Lavasanifar, and Ziyad Binkhathlan. "Design and Development of D‒α‒Tocopheryl Polyethylene Glycol Succinate‒block‒Poly(ε-Caprolactone) (TPGS−b−PCL) Nanocarriers for Solubilization and Controlled Release of Paclitaxel." Molecules 26, no. 9 (May 4, 2021): 2690. http://dx.doi.org/10.3390/molecules26092690.

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The objective of this study was to synthesize and characterize a set of biodegradable block copolymers based on TPGS-block-poly(ε-caprolactone) (TPGS-b-PCL) and to assess their self-assembled structures as a nanodelivery system for paclitaxel (PAX). The conjugation of PCL to TPGS was hypothesized to increase the stability and the drug solubilization characteristics of TPGS micelles. TPGS-b-PCL copolymer with various PCL/TPGS ratios were synthesized via ring opening bulk polymerization of ε-caprolactone using TPGS, with different molecular weights of PEG (1–5 kDa), as initiators and stannous octoate as a catalyst. The synthesized copolymers were characterized using 1H NMR, GPC, FTIR, XRD, and DSC. Assembly of block copolymers was achieved via the cosolvent evaporation method. The self-assembled structures were characterized for their size, polydispersity, and CMC using dynamic light scattering (DLS) technique. The results from the spectroscopic and thermal analyses confirmed the successful synthesis of the copolymers. Only copolymers that consisted of TPGS with PEG molecular weights ≥ 2000 Da were able to self-assemble and form nanocarriers of ≤200 nm in diameter. Moreover, TPGS2000-b-PCL4000, TPGS3500-b-PCL7000, and TPGS5000-b-PCL15000 micelles enhanced the aqueous solubility of PAX from 0.3 µg/mL up to 88.4 ug/mL in TPGS5000-b-PCL15000. Of the abovementioned micellar formulations, TPGS5000-b-PCL15000 showed the slowest in vitro release of PAX. Specifically, the PAX-loaded TPGS5000-b-PCL15000 micellar formulation showed less than 10% drug release within the first 12 h, and around 36% cumulative drug release within 72 h compared to 61% and 100% PAX release, respectively, from the commercially available formulation (Ebetaxel®) at the same time points. Our results point to a great potential for TPGS-b-PCL micelles to efficiently solubilize and control the release of PAX.
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Liu, Yude, Lian Rao, Hongguan Zhang, Yanyou Cen, and Kaili Cheng. "Conjugation of vitamin E-TPGS and guar gum to carry borneol for enhancing blood–brain barrier permeability." Journal of Biomaterials Applications 33, no. 4 (September 12, 2018): 590–98. http://dx.doi.org/10.1177/0885328218799551.

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Herb borneol is usually used in clinics for the treatment of central nervous system illness, for its ability of blood–brain barrier permeability, although its poor water solubility and poor bioavailability limit its clinical application to some degree. In this study, we developed a novel nanoparticle combining the benefits of vitamin E d-ɑ-tocopheryl poly(ethylene glycol) succinate (E-TPGS) (or TPGS) and guar gum to get TPGS-g-guar gum as a drug delivery system to carry borneol, which could improve the solubility of borneol and increase the drug-loading capacity efficiently. The results showed that TPGS-g-guar gum nanoparticles delivery system was suitable to carry borneol and release the drug effectively, and TPGS-g-guar gum/borneol nanoparticles would be a potential platform for improving the treatment of central nervous system illness and cerebrovascular disease.
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Dissertations / Theses on the topic "TPGS"

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Muenyi, Clarisse Sornsay. "Cell Toxicology Study of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS)." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/1037.

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This research focused on the cytotoxic properties of RRR-alpha-tocopheryl polyethylene glycol 1000 succinate (TPGS) in transformed and cancerous cell lines. We used RAW264.7 macrophage and prostate cancer (LNCaP) cell lines in this study. TPGS caused cell death and decreased cell viability in a dose and time dependent manner. Cell death was evaluated fluorimetrically by employing the nucleic acid-binding fluorophore; propidium iodide. A colorimetric 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay was used to evaluate cell viability. Cell death can occur through necrosis or apoptosis. Our results suggested that TPGS triggered apoptotic cell death. Induction of apoptosis, as measured by caspase 3 enzymatic activity, was dependent upon the TPGS dose and incubation time. Caspase 8 was activated before caspase 9, suggesting the importance of the death receptor pathway in apoptosis. Our results indicated that TPGS cytotoxicity could also be due to one of its products of hydrolysis, alpha-tocopheryl succinate.
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Santos, Adriane Gasparino dos [UNESP]. "Efeito da vitamina E-TPGS hidromiscível sobre as alterações nutricionais e a lesão hepática na colestase crônica." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/104681.

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Made available in DSpace on 2014-06-11T19:33:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-16Bitstream added on 2014-06-13T19:23:22Z : No. of bitstreams: 1 santos_ag_dr_botfm_prot.pdf: 1292610 bytes, checksum: 023b1ade3c67039310cf3b6cd129631a (MD5)
A colestase crônica por ligadura e ressecção do ducto biliar em ratos jovens é freqüentemente utilizada como modelo experimental de atresia biliar. Na colestase ocorre má absorção de vitamina E com resultante estresse oxidativo. Objetivos: Sendo a vitamina E-TPGS hidromiscível, e portanto absorvível mesmo na colestase, testamos os seus efeitos sobre as conseqüências nutricionais, sobre as alterações do metabolismo lipídico e sobre a lesão hepática da colestase obstrutiva crônica no modelo experimental acima. Métodos: Quarenta ratos machos da raça Wister com 21 dias de vida (P21) foram divididos em 4 grupos de 10 animais e submetidos a um dos seguintes tratamentos: 1) LA-ligadura e ressecção do ducto biliar comum e administração diária de água, por gavagem, num volume de 0,02ml por grama de peso do animal; 2) LELigadura e ressecção do ducto biliar comum e administração diária, por gavagem, de 25UI/kg num volume de 0,02ml de vitamina E-TPGS por grama de peso do animal de uma solução a 20% de vitamina E-TPGS; 3) SA-operação simulada e administração diária de água, por gavagem, num volume de 0,02ml por grama de peso do animal; 4) SE-operação simulada e administração diária, por gavagem, de 25Ul/kg num volume de 0,02ml de vitamina E-TPGS por grama de peso do animal de uma solução a 20% de vitamina E-TPGS. Durante o experimento foi determinado o ganho de peso, a quantidade de ração ingerida, o aproveitamento nutricional (P21 a P49) e balanço nitrogenado (P42 aoP49). No P48, foram submetidos ao teste do tempo de sono após pentobarbital. No P49, foram sacrificados e colhido sangue e órgãos para seguintes determinações: peso fresco, conteúdo de água e gordura da carcaça, fígado e baço, concentrações séricas de colesterol-T, triacilglicerol, LOL-colesterol, VLDL-colesterol, HDL-colesterol, albumina, globulinas totais, vitamina A e E, atividade sérica das aminotransferases (ALT e AST).
Chronic cholestasis by bile duct ligature and resection in young rats is a commonly used experimental model of biliary atresia. Vitamin E absorption is poor in cholestasis causing oxidative stress. Objectives: As Vitamin E-TPGS dissolves in water, and is therefore absorbable even in cholestasis, we tested its effects on nutritional outcome, Iipid metabolism alterations, and hepatic lesion from chronic obstructive cholestasis in the above mode!. Methods: Forty 21-day-old male Wistar rats (P21) were divided into four groups of 10 and submitted to the following treatments: 1) LA - ligature and common bile duct resection with daily administration of water by gavage (0.02ml/g animal weight); 2) LE- ligature and common bile duct resection with daily administration of 251U/Kg Vitamin E-TPGS in water by gavage (0.02mLlg wt of 20% Vitamin E-TPGS solution); 3) SA - sham operation and daily administration of water by gavage (0.02ml/g wt); and 4) SE - sham operation and daily administration of 251U/Kg Vitamin E-TPGS in water by gavage (0.02ml/g wt of 20% Vitamin E-TPGS solution). During the experiment we measured weight gain, ingested food, diet utilization (P21 to P49), and nitrogen balance (P42 to P49). On P48, pentobarbital sleeping time was measured. On P49, eutanasia was carried out and blood and organs were collected to determine: body,liver, and spleen fresh weight, and water and fat content, serum levels of total cholesterol, triacylg Iycerols, LDL-cholesterol, VLDL -cholesterol, HOL-cholesterol, albumin, total globulins, Vitamin A & E, and ALT & AST activity. Also liver histological sections were analyzed for fibrosis intensity, duct proliferation, necrosis, steatosis, hydropic degeneration, inflammation, and mitosis frequency. The effects of cholestasis, Vitamin E-TPGS, and their interactions were tested by ANOVA with two factors, and multiple paired comparisons... (Complete abstract click electronic access below)
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Santos, Adriane Gasparino dos. "Efeito da vitamina E-TPGS hidromiscível sobre as alterações nutricionais e a lesão hepática na colestase crônica /." Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/104681.

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Orientador: Cláudio Antônio Rabello Coelho
Banca: Cilmery S. Kurokwa
Banca: Rosangela Maria Barone
Banca: Ana Paula R. Battochio
Banca: Maria Ângela
Resumo: A colestase crônica por ligadura e ressecção do ducto biliar em ratos jovens é freqüentemente utilizada como modelo experimental de atresia biliar. Na colestase ocorre má absorção de vitamina E com resultante estresse oxidativo. Objetivos: Sendo a vitamina E-TPGS hidromiscível, e portanto absorvível mesmo na colestase, testamos os seus efeitos sobre as conseqüências nutricionais, sobre as alterações do metabolismo lipídico e sobre a lesão hepática da colestase obstrutiva crônica no modelo experimental acima. Métodos: Quarenta ratos machos da raça Wister com 21 dias de vida (P21) foram divididos em 4 grupos de 10 animais e submetidos a um dos seguintes tratamentos: 1) LA-ligadura e ressecção do ducto biliar comum e administração diária de água, por gavagem, num volume de 0,02ml por grama de peso do animal; 2) LELigadura e ressecção do ducto biliar comum e administração diária, por gavagem, de 25UI/kg num volume de 0,02ml de vitamina E-TPGS por grama de peso do animal de uma solução a 20% de vitamina E-TPGS; 3) SA-operação simulada e administração diária de água, por gavagem, num volume de 0,02ml por grama de peso do animal; 4) SE-operação simulada e administração diária, por gavagem, de 25Ul/kg num volume de 0,02ml de vitamina E-TPGS por grama de peso do animal de uma solução a 20% de vitamina E-TPGS. Durante o experimento foi determinado o ganho de peso, a quantidade de ração ingerida, o aproveitamento nutricional (P21 a P49) e balanço nitrogenado (P42 aoP49). No P48, foram submetidos ao teste do tempo de sono após pentobarbital. No P49, foram sacrificados e colhido sangue e órgãos para seguintes determinações: peso fresco, conteúdo de água e gordura da carcaça, fígado e baço, concentrações séricas de colesterol-T, triacilglicerol, LOL-colesterol, VLDL-colesterol, HDL-colesterol, albumina, globulinas totais, vitamina A e E, atividade sérica das aminotransferases (ALT e AST).
Abstract: Chronic cholestasis by bile duct ligature and resection in young rats is a commonly used experimental model of biliary atresia. Vitamin E absorption is poor in cholestasis causing oxidative stress. Objectives: As Vitamin E-TPGS dissolves in water, and is therefore absorbable even in cholestasis, we tested its effects on nutritional outcome, Iipid metabolism alterations, and hepatic lesion from chronic obstructive cholestasis in the above mode!. Methods: Forty 21-day-old male Wistar rats (P21) were divided into four groups of 10 and submitted to the following treatments: 1) LA - ligature and common bile duct resection with daily administration of water by gavage (0.02ml/g animal weight); 2) LE- ligature and common bile duct resection with daily administration of 251U/Kg Vitamin E-TPGS in water by gavage (0.02mLlg wt of 20% Vitamin E-TPGS solution); 3) SA - sham operation and daily administration of water by gavage (0.02ml/g wt); and 4) SE - sham operation and daily administration of 251U/Kg Vitamin E-TPGS in water by gavage (0.02ml/g wt of 20% Vitamin E-TPGS solution). During the experiment we measured weight gain, ingested food, diet utilization (P21 to P49), and nitrogen balance (P42 to P49). On P48, pentobarbital sleeping time was measured. On P49, eutanasia was carried out and blood and organs were collected to determine: body,liver, and spleen fresh weight, and water and fat content, serum levels of total cholesterol, triacylg Iycerols, LDL-cholesterol, VLDL -cholesterol, HOL-cholesterol, albumin, total globulins, Vitamin A & E, and ALT & AST activity. Also liver histological sections were analyzed for fibrosis intensity, duct proliferation, necrosis, steatosis, hydropic degeneration, inflammation, and mitosis frequency. The effects of cholestasis, Vitamin E-TPGS, and their interactions were tested by ANOVA with two factors, and multiple paired comparisons... (Complete abstract click electronic access below)
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Baréa, Silvana Azambuja. "Dispersões sólidas contendo talidomida : desenvolvimento, caracterização e avaliação das propriedades biofarmacêuticas in vitro." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2014. http://hdl.handle.net/10183/149461.

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A talidomida (TLD) é um fármaco usado no tratamento de lesões associadas ao eritema nodoso leprótico, úlceras aftóides em pacientes HIV+/AIDS, algumas doenças crônico-degenerativas e mieloma múltiplo refratário à quimioterapia. Porém, apresenta problemas relacionados à sua farmacocinética, é pouco hidrossolúvel, e, por conseguinte, apresenta lenta e variável absorção no trato gastrintestinal. Uma proposta inédita que pode ser de interesse clínico é a formulação de uma dispersão sólida para a via oral, que permita a modulação da dissolução e biodisponibilidade da talidomida. O objetivo deste trabalho foi desenvolver e caracterizar dispersões sólidas (DS) contendo carreadores autoemulsionáveis e TLD, veiculado em cápsulas duras, a fim de melhorar as propriedades biofarmacêuticas do fármaco. Foram desenvolvidas formulações de TLD dispersa em Gelucire® (GEL) ou Kolliphor® (TPGS), associadas ou não a um adjuvante que em geral, diminui a recristalização de fármacos, a polivilpirrolidona (PVP K30). A técnica utilizada para preparar as DS foi o método de evaporação de solvente. A caracterização físico-química foi realizada por microscopia eletrônica de varredura (MEV), difração de raios-X (DRX), calorimetria exploratória diferencial (DSC) acoplada a células de aquecimento (Hot Stage), sugeriu formação de DS semicristalinas. A espectroscopia Infravermelha (IV), juntamente com DRX, demonstrou que a porção cristalina remanescente corresponde ao polimorfo α. A dissolução in vitro do fármaco a partir das DS foi significativamente melhor quando comparada ao fármaco isolado ou ao controle com amido. No tempo limite de 120 minutos, as DS tiveram percentual de dissolução em torno de 90%, enquanto o fármaco isolado de 50%, e o controle com amido de 70%. O estudo de solubilidade aquosa com diferentes excessos de fármaco foi realizado com o intuito de verificar se as DS eram capazes de manter o aumento da solubilidade aparente (estado de supersaturação) por um longo período de tempo. Foram obtidos incrementos da solubilidade aparente de até 3x superiores a do fármaco isolado, mas a capacidade solubilizante das DS mostrou-se saturável. Como conclusão, os resultados das análises físico-químicas, perfil de dissolução e solubilidade sugerem que a associação da talidomida com os carreadores autoemulsionáveis proporcionou melhora nas propriedades biofarmacêuticas da TLD, e criam perspectivas de investigação futuras, tais como a avaliação da permeabilidade intestinal in vitro.
Thalidomide (TLD) is a drug used for the treatment of lesions associated to the erythema nodosum leprosum, aphthous ulcers in HIV + / AIDS patients, some chronic diseases, and multiple myeloma refractory to chemotherapy. However, the drug is poorly aqueous soluble, and therefore presents slow and variable absorption in the gastrointestinal tract. An innovative proposal, which could be of clinical interest, is the formulation of oral solid dispersions, which allow modulation of dissolution, solubility, and, therefore, bioavailability of thalidomide. The objective of this study was to develop and characterize solid dispersions (DS) containing self-emulsifying carriers and TLD, filled in hard capsules, aiming to improve the biopharmaceutical properties of the drug. TLD has been dispersed in Gelucire® (GEL) or Kolliphor® (TPGS), associated or not to an excipient that usually decreases the drug recrystallization, polyvinylpyrrolidone (PVP K30). The technique used for preparing the DS was the solvent evaporation method. The physicochemical characterization by scanning electron microscopy (SEM), X-ray diffraction (XRD), differential scanning calorimetry (DSC) coupled to heating cells (Hot Stage), indicated the formation of semi crystalline DS. Infrared spectroscopy (IR), together with XRD, showed that the remaining crystalline portion corresponds to the polymorph α. The in vitro dissolution of the drug from the DS was significantly higher when compared to the drug alone, or the control with starch. At 120 min, the percentage of TLD dissolved from DS was around 90%, while drug alone showed 50% and drug+starch showed 70% dissolution. The aqueous solubility study performed with different drug excess assessed whether the DS were able to maintain the increase in apparent solubility (supersaturation state) for a long period of time. Increments around 3x were obtained in the apparent solubility, but the solubilizing ability of DS was found to be saturable. In conclusion, the results of physicochemical analysis, dissolution profile and aqueous solubility suggest that the association of thalidomide with self-emulsifying carriers provided improvement on the biopharmaceutical properties of TLD, and opened future research perspectives, such as the assessment of intestinal permeability in vitro.
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Komguem, Kamga Christelle. "Cell Toxicity and Uptake of RRR-Alpha-Tocopheryl Polyethylene Glycol 1000 Succinate (TPGS) by Various Cell ines In Vitro." Digital Commons @ East Tennessee State University, 2005. https://dc.etsu.edu/etd/1040.

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This research focused on investigating and comparing the cytotoxicity and cellular uptake of RRR-alpha-tocopheryl polyethylene glycol succinate (TPGS, with that of alpha-tocopheryl succinate (α-TS). Both TPGS and α-TS are water-soluble forms of vitamin E with important clinical applications. Cytotoxicity assays with RAW 264.7 and LNCaP cells incubated overnight with TPGS or α-TS at concentrations ≥ 12.4 μM suggest that α-TS is more cytotoxic than TPGS. Macrophages were found to be more sensitive than LNCaP cells when treated with similar concentrations of α-TS. For both cell lines, most of the TPGS or α-TS taken up remained esterified after 24 hours. Our results suggest that cell death was due to TPGS and/or α-TS and not alpha-tocopherol. A para-hydroxyanilide of α-TS (p-HATS) that could be used to distinguish between cellular TPGS and α-TS was studied. It was found that p-HATS can be detected electrochemically and that it is hydrolyzed to α-TOH.
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Souza, Marina Claro de. "Micelas de longo tempo de circulação contendo tamoxifeno como sistema nanocarreador para otimização da terapia do câncer de mama." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-23052018-143506/.

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O câncer de mama é a segunda principal causa de morte entre as mulheres nos países em desenvolvimento, devido ao seu alto grau de malignidade. O tratamento baseia-se, principalmente, em terapias hormonais, uma vez que as células deste tipo de tumor expressam, em sua maioria, um elevado número de receptores hormonais, responsáveis pela regulação do crescimento do mesmo. O tamoxifeno é um fármaco da classe dos moduladores seletivos de receptores de estrógeno, que atua através do antagonismo à ativação de tais receptores por este hormônio, reduzindo, assim, a taxa de crescimento celular do tecido tumoral. Embora o tratamento com tamoxifeno seja altamente efetivo, este se relaciona a severos efeitos colaterais dosedependentes. O objetivo central deste trabalho foi desenvolver sistemas micelares de longo tempo de circulação contendo tamoxifeno, preparados à base do fosfolipídeo DSPE-PEG(n), associado ou não ao derivado de vitamina E TPGS, para administração intravenosa, capazes de permitir um acúmulo maior do fármaco no sítio tumoral devido a suas dimensões nanométricas, permitindo, desta forma, a redução da dose e a consequente redução dos efeitos colaterais. A determinação da eficiência de encapsulação e a quantificação do tamoxifeno no estudo de liberação in vitro a partir dos sistemas obtidos foram realizadas por CLAE, utilizando métodos previamente validados. Os melhores resultados foram alcançados com as formulações à base de DSPE-PEG(2000) e TPGS, preparadas pelo método de evaporação do solvente, as quais apresentaram diâmetro médio inferior a 20 nm, baixo índice de polidispersividade e eficiência de encapsulação entre 70 e 95%. A análise por microscopia eletrônica de transmissão evidenciou o formato esférico e comprovou a homogeneidade do tamanho das partículas. Os sistemas foram caracterizados, ainda, por espectrofotometria no infravermelho para avaliação de possíveis interações entre os componentes das formulações. O perfil de liberação in vitro demonstrou que após 168 h, no máximo cerca de 30% do fármaco foi liberado, verificando-se que o aumento na quantidade de TPGS na formulação reduziu a porcentagem de tamoxifeno liberado. A baixa taxa de liberação in vitro sugere que a maior parte do fármaco mantenha-se no interior da estrutura micelar durante o período de permanência no sangue, favorecendo a chegada da nanoestrutura íntegra ao sítio tumoral. No estudo do perfil de concentração plasmática em ratas Wistar, não foi possível detectar o fármaco e seu principal metabólito pelo método por CLAE desenvolvido, sugerindo que os sistemas micelares tenham extravasado rapidamente para os órgãos.
Breast cancer is the second main cause of death among women in development countries due to their high malignance grade. The treatment is mainly based on hormonal therapies, once the cells of the majority of mammary tumors express a high number of hormone receptors, responsible for the tumor growth. Tamoxifen is a selective estrogen receptor modulator drug, acting through the antagonism of the activation of the estrogen receptor, reducing thus the tumor growing rate. Despite the treatment with tamoxifen is highly effective, it is related to severe dose-dependent side effects. The central objective of this work was the development of long time circulation micelles containing tamoxifen, prepared with the phospholipid DSPEPEG(n) and TPGS, a vitamin E derivative, by the method of solvent evaporation, for intravenous administration, able to allow a higher accumulation of the drug at the tumoral site due to their nanometric dimensions, leading to a reduction in the dose and consequently in the side effects. The determination of the encapsulation efficiency and the quantification of tamoxifen in the in vitro release profile study from the micellar systems were carried out by HPLC, using methods previously validated. The best results were achieved with the formulations based on DSPE-PEG(2000) and TPGS, which showed mean particle diameter less than 20 nm, low polydispersity index and encapsulation efficiency ranging from 70 to 95%. The transmition electronic microscopy pointed the spherical shape and proved the homogeneity of particle size. The systems were also characterized by infrared spectrophotometry to identify eventual interactions among the components of the formulations. The in vitro release profile study showed that after 168 h, a maximum of about 30% of tamoxifen was released, evidencing that the increase of the TPGS amount in the formulation reduced the amount of tamoxifen released. The low rate of in vitro release drug suggests that the major part of the drug will remain encapsulated during the period of blood permanence, favoring the arrival of the intact nanostructure at the tumoral site. During the evaluation of the plasmatic concentration profile, conducted with Wistar rats, it was not possible to detect neither the tamoxifen nor its main metabolite, suggesting that the intact micelles may have quickly accumulated in the organs.
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Schütten, Markus. "Konzept eines COM-basierten technischen Produktinformationssystems (TPIS)." [S.l. : s.n.], 2001. http://deposit.ddb.de/cgi-bin/dokserv?idn=962834858.

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Albozahid, Muayad. "Design of novel high modulus TPUs for nanocomposite applications." Thesis, University of Manchester, 2018. https://www.research.manchester.ac.uk/portal/en/theses/design-of-novel-high-modulus-tpus-for-nanocomposite-applications(ce7989db-b70d-46a3-8c11-6793a6d9e235).html.

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This thesis focuses on designing thermoplastic nanocomposites with good mechanical, thermal and electrical properties. Thermoplastic nanocomposites, which are used in this work, are composed of thermoplastic polyurethane (TPU) matrices and graphene nanofillers (GNFs). TPUs were synthesised with large ratios of hard segments (HS), including 60, 70 and 80 Wt. % HS. The influences of HS content and annealing treatment at 80oC on the thermal, electrical and mechanical properties of TPUs and TPUs/GNFs samples have been investigated. The crystallinity, Tg, tensile strength, yield strength, and tensile modulus of all pure TPU samples are seen to increase after annealing treatment due to microphase separation. This also depends on the HS content in order to achieve better properties with various annealing times. The nanofillers include graphene nanoplatelets (GNP), graphene oxide (GO), and reduced graphene oxide (rGO). Various dispersion routes have been utilised to achieve better dispersion and distribution of the nanofillers. In-situ polymerisation, melt-compounding and solution-mixing techniques have been used to study dispersion effects and further moulding by injection moulding to prepare new TPU nanocomposites. Filler-matrix and filler-filler interfaces significantly influence the final performance of TPU nanocomposites. There is therefore a balance to be struck in the design of graphene-based TPU nanocomposites between the ability to achieve higher loadings of reinforcement and the reduction in effective Young’s modulus of the reinforcement as the number of layers in the nanofillers is increased. Effective stress transfer is achieved as a result of both dispersion and interfacial interaction. It has been demonstrated that graphene plays a reinforcing role in nanocomposites through its effective modulus as well as bonding with TPU phases. The first nanofiller studied is GNP, which shows good mechanical, thermal and electrical properties. The in-situ polymerisation approach was found to be the best dispersion method compared to melt compounding and solution mixing, as the optimum properties of GNP nanofillers can be achieved in the TPU/70 HS matrix. The TPU/70 HS had higher values compared to both TPU/60 HS and TPU/80 HS. However, the preparation of GO and rGO incorporating TPU/70 HS was not successfully synthesised due to the suppression of chain growth during polymerisation. Thus, the melt-compounding process was used instead for both GO- and rGO-based TPU matrices. TPU/70/GO nanocomposites displayed better mechanical performance compared to TPU/70/rGO nanocomposites, as a result of greater interaction between TPUs chains and fillers surfaces. It was found that the percolation thresholds for GO- and rGO-filled nanocomposites were significantly lower than that of GNP-filled nanocomposites due to their higher aspect ratio. Annealing treatment showed lower mechanical properties of TPU nanocomposite samples compared to non-annealed TPU nanocomposite samples, resulting from disruption of phase separation and restacking of nanofillers. The tensile moduli of nanocomposites were predicted using modified Halpin-Tsai models. Results showed good agreement at low loadings of GNP (≤1, 3 and 5 Wt. %), which depend on the effect of TPU phase interaction. However, poor agreement was observed at higher loadings of nanofillers, where the TPU nanocomposites displayed reduced reinforcement efficiency. This is due to the fact that the model assumes perfect adhesion between the nanofillers and the matrix, uniform particle dispersion and distribution, and complete exfoliation and total orientation in the direction of applied stress. This also correlates with results from SEM, TEM, POM and diffusivity mapping images, which showed aggregation, agglomeration and poorer distribution of nanofillers in the TPU matrix at higher loadings.
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Barro, Alessandro. "Indirect TPMS improvement: sensor fusion with ultrasound parking sensors." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021. http://amslaurea.unibo.it/23765/.

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Pre-feasibility analysis on the optimization of the performance of the indirect tyre pressure monitoring system through a sensor fusion with a new generation of ultrasound parking sensors: from the idea to the development of macro project specifications and macro business case, with definition of the possible new scenario in terms of performance, costs and perceived quality
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Geca, Piotr. "Assessment of TPUs for use in the laser sintering process." Thesis, University of Sheffield, 2016. http://etheses.whiterose.ac.uk/16771/.

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Additive Manufacturing (AM) technologies and especially the Laser Sintering (LS) systems have made an enormous impact on the manufacturing market in the last decade and their adoption continues to grow. Currently, the market of sinterable polymer powders is heavily dominated by polyamides (PAs), which fail to address all the possible LS application niches. Thermoplastic Elastomers (TPEs) and more specifically Thermoplastic Polyurethanes (TPUs) have the potential of broadening LS applications, by offering alternative, rubber-like properties to manufactured parts. Laser Sintering is a highly demanding process in regards to materials' thermal properties, as well as bulk properties of its powder form. In the first part of project we assessed TPU powder's compatibility with the Formiga P100 LS system. We found that the greatest obstacle to powder's safe use was its poor ability to flow and the resulting incompatibility with the powder deposition system. Improvement of flow properties was attempted by use of annealing process as well as addition of flow agent (FA). We found neither solution to produce satisfactory bulk properties, but we note that higher levels of FA are likely to increase the additive's effectiveness. In the second part of the project we assessed the performance of twelve diverse batches of TPU, to form a better understanding of factors influencing the mechanical performance of sintered parts. Based on a new paradigm, the sintering process was split into issues of particle coalescence and densification. We found that the particle size and melt viscosity had a strong effect on the strength of interparticle bonds formed in a limited sintering time. When long sintering time was simulated by oven-sintering, we found that parts' density was chiefly determined by powders' ability to cross over into closed-pore densification stage. Powders with Specific Surface Area of 90m²/kg and less were unable to densify and formed a stable open-pore structure instead. Avoiding this threshold condition is the first priority in designing future powder batches.
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Books on the topic "TPGS"

1

Schlechter, Melvin. Metallocene elastomers/TPEs. Norwalk, CT: Business Communications Co., 1996.

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Höfling, Wolfram, and Steffen Augsberg. TPG: Transplantationsgesetz : Kommentar. 2nd ed. Berlin: Erich Schmidt, 2013.

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FEDERAL AVIATION ADMINISTRATION. Third party draft system (TPDS) accounting procedures. [Washington, D.C.?]: Dept. of Transportation, Federal Aviation Administration, 1994.

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Woinikow, Karina. Richtlinien der Transplantationsmedizin: Zur Verfassungsmässigkeit des [Paragraph] 16 TPG. Frankfurt am Main: PL Academic Research, 2014.

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Chilver, A. S. The economic viability of true potato seed (TPS) in Indonesia. Lima, Perú: International Potato Center, 1994.

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Domingue, Richard-Philippe. La TPS: Un survol de certaines des solutions de rechange. Ottawa, Ont: Bibliothèque du Parlement, Service de recherche, 1993.

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Kerr, Patricia A. User's guide: Steady-state aerodynamic-loads program for shuttle TPS tiles. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1986.

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Kerr, Patricia A. User's guide: Steady-state aerodynamic-loads program for shuttle TPS tiles. Hampton, Va: National Aeronautics and Space Administration, Langley Research Center, 1986.

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Briscoe, Margaret. The prognostic value of CA125 and TPS in epithelial ovarian carcinoma. [S.l: The Author], 1994.

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Nakamura, Keisuke. Toyota in Indonesia: A case study on the transfer on the TPS. [Depok, Indonesia]: Center for Japanese Studies, University of Indonesia, 1999.

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Book chapters on the topic "TPGS"

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Yao, Mingyi, and Tamer Elbayoumi. "Anionic and Cationic Vitamin E-TPGS Mixed Polymeric Phospholipid Micellar Vehicles." In Pharmaceutical Nanotechnology, 31–41. New York, NY: Springer New York, 2019. http://dx.doi.org/10.1007/978-1-4939-9516-5_3.

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Naskar, Kinsuk, and R. Rajesh Babu. "Thermoplastic Elastomers (TPEs) and Thermoplastic Vulcanizates (TPVs)." In Encyclopedia of Polymeric Nanomaterials, 2517–22. Berlin, Heidelberg: Springer Berlin Heidelberg, 2015. http://dx.doi.org/10.1007/978-3-642-29648-2_310.

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Naskar, Kinsuk, and R. Rajesh Babu. "Thermoplastic Elastomers (TPEs) and Thermoplastic Vulcanizates (TPVs)." In Encyclopedia of Polymeric Nanomaterials, 1–7. Berlin, Heidelberg: Springer Berlin Heidelberg, 2014. http://dx.doi.org/10.1007/978-3-642-36199-9_310-1.

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Gooch, Jan W. "TPS." In Encyclopedic Dictionary of Polymers, 757. New York, NY: Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_11994.

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Rosso, Stefano, Andrea Curtarello, Federico Basana, Luca Grigolato, Roberto Meneghello, Gianmaria Concheri, and Gianpaolo Savio. "Modeling Symmetric Minimal Surfaces by Mesh Subdivision." In Lecture Notes in Mechanical Engineering, 249–54. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-70566-4_40.

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AbstractThanks to the great diffusion of additive manufacturing technologies, the interest in lattice structures is growing. Among them, minimal surfaces are characterized by zero mean curvature, allowing enhanced properties such as mechanical response and fluidynamic behavior. Recent works showed a method for geometric modeling triply periodic minimal surfaces (TPMS) based on subdivision surface. In this paper, the deviation between the subdivided TPMS and the implicit defined ones is investigated together with mechanical properties computed by numerical methods. As a result, a model of mechanical properties as a function of the TPMS thickness and relative density is proposed.
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Han, Lingtao, Ted Huang, and Wei Xu. "Engineering Design of TPMS." In Lecture Notes in Electrical Engineering, 107–13. Berlin, Heidelberg: Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-33829-8_11.

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Zhang, Lixian, Ting Yang, Peng Shi, and Yanzheng Zhu. "Composite TPs Case." In Analysis and Design of Markov Jump Systems with Complex Transition Probabilities, 71–85. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-28847-5_5.

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Camenisch, Jan, Manu Drijvers, and Anja Lehmann. "Anonymous Attestation with Subverted TPMs." In Advances in Cryptology – CRYPTO 2017, 427–61. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63697-9_15.

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Arthur, Will, David Challener, and Kenneth Goldman. "Existing Applications That Use TPMs." In A Practical Guide to TPM 2.0, 39–50. Berkeley, CA: Apress, 2015. http://dx.doi.org/10.1007/978-1-4302-6584-9_4.

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Yates, John T. "Temperature-Programmed Reaction Spectroscopy (TPRS)." In Experimental Innovations in Surface Science, 404–6. New York, NY: Springer New York, 1997. http://dx.doi.org/10.1007/978-1-4612-2304-7_119.

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Conference papers on the topic "TPGS"

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Poda, Anil B., C. M. Riley, Josh Perkel, R. N. Hampton, Shashi Patel, and Thomas Lancaster. "A Simulation Model to Analyze Current Split Distribution of Multiple Temporary Protective Grounds (TPGs)." In 2019 IEEE Power & Energy Society General Meeting (PESGM). IEEE, 2019. http://dx.doi.org/10.1109/pesgm40551.2019.8973626.

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Zheng, Yi, Laiqiang Huang, and Lin Mei. "Notice of Retraction: Docetaxel-Loaded TPGS-b-(PLA-ran-PGA) Nanoparticles for Cervix Cancer Treatment." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5780321.

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Li, P. Y., P. S. Lai, and C. C. Lin. "Reversal of multidrug resistance using poly(L-lactide)-vitamin E TPGS micelles in breast cancer cell." In 2009 International Conference on Biomedical and Pharmaceutical Engineering (ICBPE). IEEE, 2009. http://dx.doi.org/10.1109/icbpe.2009.5384064.

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Huang, Dale H. Y., Thanh N. Tran, and Bao Yang. "Reactive Heat Source for Standalone Thermoelectric Power Generator: Thermal Analysis of Pyrophoric Iron Mixture." In ASME 2011 International Mechanical Engineering Congress and Exposition. ASMEDC, 2011. http://dx.doi.org/10.1115/imece2011-63695.

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The idea of a small size, light weight, robust, scalable and standalone power generators has always been of great interest in personal and commercial transportation systems as well as military weapon systems. One potential source of portable power is electricity produced from heat sources through the use of thermoelectric materials. The heat can come from the combustion of fossil fuels, from sunlight, or as a byproduct of various processes (e.g. combustion, chemical reactions and nuclear decay) and in our case, a pyrophoric iron mixture that spontaneously generates heat as soon as it reacts with air. In this study, to apply the pyrophoric powder as a portable heat source for the thermoelectric power generators (TPGs), the final mixture composition is determined to be iron powder, activated carbon, and salt. With the characterization of thermal analysis techniques such as differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA), this exothermic reaction generates 9000+ J/g of heat with peak temperature ranges from 400 to 500 degrees Celsius.
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Koohi, Somayyeh, and Shaahin Hessabi. "Empirical Analysis of the Dependence of Test Power, Delay, Energy and Fault Coverage on the Architecture of LFSR-Based TPGs." In 22nd IEEE International Symposium on Defect and Fault-Tolerance in VLSI Systems (DFT 2007). IEEE, 2007. http://dx.doi.org/10.1109/dft.2007.27.

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Prashant, Chandrasekharan, Maity Dipak, Yong Cai Xian, Chuang Kai-Hsiang, Ding Jun, and Feng Si Shen. "Superparamagnetic iron oxides formulated in polylactide-co-glycolide/ D-alpha-tocopherol polyethylene glycol 1000 succinate (PLGA/TPGS) nanoparticles for high contrast MRI." In 2011 1st Middle East Conference on Biomedical Engineering (MECBME). IEEE, 2011. http://dx.doi.org/10.1109/mecbme.2011.5752145.

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Neophytou, Christiana M., Constantina Constantinou, and Andreas I. Constantinou. "Abstract 4903: D-alpha-tocopheryl polyethylene glycol succinate (TPGS) induces apoptosis and cell cycle arrest selectively in breast cancer cells by targeting aberrantly activated pathways engaging survivin signaling." In Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL. American Association for Cancer Research, 2012. http://dx.doi.org/10.1158/1538-7445.am2012-4903.

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Ferraiuolo, Michele, Oronzio Manca, and Aniello Riccio. "A Procedure to Evaluate the Thermal Response of a Multilayered Thermal Protection System Subjected to Aerodynamic Heating." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-12327.

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Next generation reusable re-entry vehicles must be capable of sustaining consistent repeated aero-thermal loads without damage or deterioration. This means that such structures must tolerate the high temperatures engendered by aero-thermal re-entry fluxes due to the establishment of a hypersonic regime over the body. Thermal Protection Systems (TPS) are used to maintain a reusable launch vehicle’s structural temperature within acceptable limits during re-entry flights; that is, internal temperature should not overcome the temperature limit use of the internal structure. TPS are usually composed by several layers made of different materials. Heat transfer through a multilayer insulation during atmospheric re-entry involves combined modes of heat transfer: heat conduction through the solid, heat radiation to the outer space etc. In the frame of TPS design activities a procedure based on one dimensional analytical solutions of transient nonlinear analyses has been developed in order to estimate the temperature variation with time and space of a multilayered body subjected to aerodynamic heating inside a radiating space. Since internal temperature values of TPSs of re-entry vehicles cannot exceed certain values, that procedure allows to quickly evaluate those temperature values and to preliminary size layer thicknesses before preparing and performing Finite Element analyses.
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Yu, Jingjun, Shusheng Bi, Guanghua Zong, and Yuefa Fang. "Geometric Synthesis and Enumeration of the Family of 3-DOF Translational Parallel Manipulators via the Screw Theory." In ASME 2004 International Design Engineering Technical Conferences and Computers and Information in Engineering Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/detc2004-57281.

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In this paper, a systematic method based on the screw theory is proposed for the geometric synthesis of a family of 3-DoF translational parallel manipulators (TPMs). The theory of screws and reciprocal screws is employed for the analysis of the geometric conditions undergoing the different types of constraints for the TPMs. In terms of these established geometric conditions, limb structures that can be used for constructing TPMs are enumerated, and a number of novel TPMs including both symmetrical structure and asymmetrical structure are synthesized accordingly. On the other hand, some composite kinematic pairs are proposed. The involvement of these composite kinematic pairs into the limbs of a TPM greatly enlarges the family of the TPMs.
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"Preface TPCS." In 2021 Picture Coding Symposium (PCS). IEEE, 2021. http://dx.doi.org/10.1109/pcs50896.2021.9477402.

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Reports on the topic "TPGS"

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Landron, C. O., and G. T. Baldwin. Time Projection Compton Spectrometer (TPCS). User`s guide. Office of Scientific and Technical Information (OSTI), April 1994. http://dx.doi.org/10.2172/10148465.

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Gordon, David. CAE Tools Assessment for TPS Development (Preliminary). Fort Belvoir, VA: Defense Technical Information Center, February 1991. http://dx.doi.org/10.21236/ada244633.

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Miller, J. R. Impact of several reactor features on TF coil design for TPSS. Office of Scientific and Technical Information (OSTI), January 1986. http://dx.doi.org/10.2172/6294457.

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Christ, Callista, and Brian Nord. Fast Inference on FPGAs and TPUs: Classifying Gravitational Lensing Images Efficiently. Office of Scientific and Technical Information (OSTI), August 2019. http://dx.doi.org/10.2172/1623374.

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Fassnacht, Malena, and Hugh Lippincott. Analyzing Gas Diffusion in LXe-TPCs for Upcoming Hydrogen Doping Studies. Office of Scientific and Technical Information (OSTI), August 2019. http://dx.doi.org/10.2172/1637623.

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Miller, J. R., and R. H. Bulmer. Impact of several reactor features on TF coil design for TPSS. Office of Scientific and Technical Information (OSTI), March 1986. http://dx.doi.org/10.2172/6002264.

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Gordon, Randy, Robert Fails, Solomon Baase, Jason Eckberg, Charles Ryan, and Chris Smith. USAF TPS L-23 Shear Wind Observed Optimized Path Investigation for NASA (SENIOR ShWOOPIN). Fort Belvoir, VA: Defense Technical Information Center, June 2006. http://dx.doi.org/10.21236/ada470169.

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Liu, D. D., P. C. Chen, Lei Tang, K. T. Chang, and Adel Chemaly. Integrated Hypersonic Aerothermoelastic Methodology for Transatmospheric Vehicle (TAV)/Thermal Protection System (TPS) Structural Design and Optimization. Fort Belvoir, VA: Defense Technical Information Center, January 2002. http://dx.doi.org/10.21236/ada403577.

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Krishnamurthy, Ranjani, Gayathri Sarangan, Abhilaasha Nagarajan, Reeba Devaraj, Rajesh Ramamoorthy, Blessy Oviya, and Nandini Natarajan. Gender and Social Inclusion Across the Sanitation Chain in Tamil Nadu – Assessment and Strategy. Indian Institute for Human Settlements, 2019. http://dx.doi.org/10.24943/gsiatnas10.2019.

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The Government of Tamil Nadu (GoTN) has prioritised the full sanitation chain, including the strengthening of septage management as an economical and sustainable complement to networkbased sewerage systems. The Bill and Melinda Gates Foundation (BMGF) is supporting the GoTN to achieve the Sanitation Mission of Tamil Nadu through the Tamil Nadu Urban Sanitation Support Programme (TNUSSP). TNUSSP Phase I (2015-2018) was designed to support GoTN and selected cities in making improvements along the entire urban sanitation chain. In the second phase (2018– 2020), TNUSSP seeks to go one step further and integrate a gender and social inclusion (GSI) perspective within its interventions at two sites – the city of Tiruchirappalli (Trichy), and the two town panchayats (TPs) of Periyanaicken-Palayam (PNP) and Narasimhanaicken-Palayam (NNP) in Coimbatore district – along the urban sanitation cycle and in its support provided at the State level.
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