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Journal articles on the topic 'TPO test'

Author: Grafiati

Published: 5 June 2025

Last updated: 16 July 2025

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1

Haider, Y. Abdulrazaq. "Evaluation of Thyroperoxidase and TSH Receptor Autoantibodies in Thyroid Dysfunction Patients." INTERNATIONAL JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH STUDIES 03, no. 09 (2023): 1831–34. https://doi.org/10.5281/zenodo.8321536.

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Thyroid autoimmune disease is one of the most common disorders which are generally associated with existence of anti-thyroid peroxidase (TPO) in addition to ant thyroid stimulating hormone receptor (TSHR) antibodies, and anti-thyroglobulin (Tg). The present study was a cross-sectional one, conducted on (200) patients selected randomly from cases already diagnosed with thyroid disorder diseases by a specialized endocrinology center in AL-Basra city / Iraq. Where TPO test was performed for 127 of them, and TRAB test was conducted for the remaining 73 patients. The study showed that 74% of the ca

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2

Sood, Neelam, and Jitendra Singh Nigam. "Correlation of Fine Needle Aspiration Cytology Findings with Thyroid Function Test in Cases of Lymphocytic Thyroiditis." Journal of Thyroid Research 2014 (2014): 1–5. http://dx.doi.org/10.1155/2014/430510.

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Background. Chronic lymphocytic thyroiditis is the second most common thyroid lesion diagnosed on FNAC after goiter. FNAC is reliable tool in the diagnosis of thyroid lesion.Objective. To correlate FNAC cytologic findings with TFT in the lymphocytic thyroiditis.Methods. 175 patients with thyroid swellings were referred for FNAC as well as TFT during 2011–2013. Fine needle aspiration cytology was performed using non-aspiration or aspiration techniques and TFT performed on Beckman culter access 2.Results. Lymphoid infiltrate was seen in 55 cases. The commonest age group of lymphocytic thyroiditi

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3

Dr., Tahira Jabeen Dr. Sadia Bashir Dr. Shaheena Nawab. "EVALUATION OF THYROID FUNCTION TEST IN NEPHROTIC SYNDROME PATIENTS." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 08 (2019): 15006–9. https://doi.org/10.5281/zenodo.3373784.

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<strong><em>Objective: </em></strong><em>To evaluate the thyroid dysfunction in patients of nephrotic syndrome presenting at BVH Bahawalpur.</em> <strong><em>Material and methods: </em></strong><em>In this cross-sectional study total 39 patients of nephrotic syndrome having age >18 years, both male or female were selected from Department of Pathology, Quaid-e-Azam Medical College Bahawalpur from October 2018 to April 2019.  Thyroid dysfunction was assessed in selected patients.</em> <strong><em>Results: </em></strong><em>Thirty-nine patients presented with newly diagnosed NS. The mean

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TOGAY, Alper, Banu Isbilen BASOK, Ayfer ÇOLAK, and Nisel YILMAZ. "Evaluation of the association of anti-thyroid peroxidase with antinuclear antibodies and different antinuclear antibodies patterns." Journal of Medicine and Palliative Care 4, no. 4 (2023): 311–14. http://dx.doi.org/10.47582/jompac.1317134.

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Aims: To investigate the relationship between anti-thyroid peroxidase (TPO), a marker for Hashimoto’s thyroiditis, and antinuclear antibodies (ANA) and ANA patterns, biomarkers for systemic autoimmune diseases. Methods: In this study, ANA and anti-TPO test results, obtained in our hospital laboratory between 2019 and 2022, were retrospectively evaluated. ANA was detected by the indirect immunofluorescence antibody method using commercial HEp-20-10 cell substrates and anti-TPO was determined by the sandwich immunoassay method using a commercial immunoassay analyzer. Results: A total

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Sánchez, Jorge, Andres Sánchez, and Ricardo Cardona. "Clinical Characterization of Patients with Chronic Spontaneous Urticaria according to Anti-TPO IgE Levels." Journal of Immunology Research 2019 (December 7, 2019): 1–11. http://dx.doi.org/10.1155/2019/4202145.

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Background. Chronic spontaneous urticaria (CSU) is a heterogeneous disease with some frequent comorbidities like autoimmune diseases, drug reactions, and inducible urticaria. IgE antibodies against thyroid peroxidase (anti-TPO IgE) could be associated with some of these clinical characteristics. Objective. To explore the clinical characteristics of CSU patients, according to the presence of anti-TPO IgE in serum. Methods. Anti-TPO IgE levels were measured during the clinical control period (Urticaria Activity Score, 0 point) and exacerbation period (≥3 points) in 100 CSU patients. Patients wit

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Patel, Saumil C., and Pragnesh K. Brahmbhatt. "Performance and Emission Analysis of Diesel Engine Fueled with Tyre Pyrolysis Oil and Diesel Blends." Advanced Science, Engineering and Medicine 12, no. 12 (2020): 1474–78. http://dx.doi.org/10.1166/asem.2020.2703.

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In this research work, performance and emissions of Tyre Pyrolysis Oil (TPO) in a diesel engine are experimentally examined as per Indian Standard: 10000. The main objective of this research work is to find the best proportion of blend based on performance and emission analysis. For the study, Tyre Pyrolysis Oil is added to diesel fuel, numbered D100 (pure diesel), D95T5 (by volume of 5% TPO and 95% diesel), D90T10 (by volume of 10% TPO and 90% diesel), D85T15 (by volume of 15% TPO and 85% diesel), D80T20 (by volume of 20% TPO and 80% diesel) and D75T25 (by volume of 25% TPO and 75% diesel). F

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Kowalska, Andrea, Jerzy Sokołowski, Małgorzata Iwona Szynkowska-Jóźwik, Tomasz Gozdek, Karolina Kopacz, and Kinga Bociong. "Can TPO as Photoinitiator Replace “Golden Mean” Camphorquinone and Tertiary Amines in Dental Composites? Testing Experimental Composites Containing Different Concentration of Diphenyl(2,4,6-trimethylbenzoyl)phosphine Oxide." International Journal of Molecular Sciences 23, no. 19 (2022): 11594. http://dx.doi.org/10.3390/ijms231911594.

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The aim of this research was to compare the biomechanical properties of experimental composites containing a classic photoinitiating system (camphorquinone and 2-(dimethylami-no)ethyl methacrylate) or diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) as a photoinitiator. The produced light-cured composites consisted of an organic matrix-Bis-GMA (60 wt.%), TEGDMA (40 wt.%) and silanized silica filler (45 wt.%). Composites contained 0.27; 0.5; 0.75 or 1 wt.% TPO. Vickers hardness, microhardness (in the nanoindentation test), diametral tensile strength, resistance to three-point bending and t

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Rocha, MG, DCRS de Oliveira, MAC Sinhoreti, JF Roulet, and AB Correr. "The Combination of CQ-amine and TPO Increases the Polymerization Shrinkage Stress and Does Not Improve the Depth of Cure of Bulk-fill Composites." Operative Dentistry 44, no. 5 (2019): 499–509. http://dx.doi.org/10.2341/18-234-l.

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SUMMARY Objectives: To evaluate the effect of combining camphorquinone (CQ) and diphenyl(2,4,6-trimethylbenzoyl)phosphine oxide (TPO) on the depth of cure and polymerization shrinkage stress of bulk-fill composites. Methods and Materials: Experimental bulk-fill composites were produced containing equal molar concentrations of either CQ-amine or CQ-amine/TPO. The degree of in-depth conversion through each millimeter of a 4-mm-thick bulk-fill increment was evaluated by Fourier transform near-infrared microspectroscopy using a central longitudinal cross section of the increment of each bulk-fill

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Paparodis, Rodis, Sarantis Livadas, Evangelos Karvounis, et al. "PSAT381 Rising Preoperative TPO Titers Decrease the Risk for Differentiated Thyroid Cancer in a Linear Fashion: A Retrospective Analysis of 1620 Consecutive Thyroid Surgeries." Journal of the Endocrine Society 6, Supplement_1 (2022): A846—A847. http://dx.doi.org/10.1210/jendso/bvac150.1750.

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Abstract Introduction Chronic lymphocytic thyroiditis is an important risk factor for differentiated thyroid cancer (DTC) in surgical series, but the role of thyroid peroxidase antibodies (TPO) seems less clear in that regard. We designed the present study to evaluate that effect in our large patient population. Methods We recruited subjects operated with total thyroidectomy in 4 sites (USA: 1, Greece: 3) during a period of 14 consecutive years. We gathered data on TPO antibodies titers measured with commercially available radioimmunoassays, and reviewed data on surgical pathology. TPO≥34IU/ml

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10

Ekka, Shreyasi C., Mani Bhushan K. Sinha, and Anita Kumari. "A study of autoimmune thyroid disease in pregnant women and its effect on fetal and maternal outcome." Journal of Family Medicine and Primary Care 13, no. 11 (2024): 4916–25. http://dx.doi.org/10.4103/jfmpc.jfmpc_485_24.

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ABSTRACT Introduction: Anti-thyroid antibodies not only cause thyroid dysfunction but have independent adverse outcomes in the fetus and mother during pregnancy and after birth. Chronic lymphocytic thyroiditis as a presentation of immune system deregulation may be associated with a generalized activation of the immune system at the fetus–maternal unit, the placenta. This interference could be associated with pregnancy morbidities in m o t h e r a n d fetus. This study was done to find out the frequency of autoimmune thyroid disease and its effect on maternal and fetal outcomes in a tertiary ca

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Singh, Sharanya, Mateus Garcia Rocha, Mario Alexandre Coelho Sinhoreti, Alexandre Carneiro Silvino, and Dayane Oliveira. "Cure Efficiency and Biocompatibility of an Iron-Based Coordination Complex as a Photoinitiator for Dental 3D-Printed Resins." Journal of Composites Science 9, no. 1 (2025): 26. https://doi.org/10.3390/jcs9010026.

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Objective: The aim of this study was to evaluate the cure efficiency and biocompatibility of a novel iron-based coordination complex used as a photoinitiator in comparison to conventional ethyl (2,4,6-trimethylbenzoyl) phenylphosphinate (TPO-L) and camphorquinone (CQ) as photoinitiators in dental 3D-printed resins. Materials and Methods: Experimental dental resin formulations were prepared by blending 1:1 ratio of Bis-GMA and TEGDMA, to which 0.2 wt% of either the iron-based coordination complex or CQ were added, along with 0.2 wt% EDAB and 0.4 wt% IOD, and the TPO-L. The degree of conversion

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12

Longo, Giorgio. "Domande e risposte." Medico e Bambino 44, no. 02 (2025): 123. https://doi.org/10.53126/meb44123.

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Makar, Robert, Olga S. Zhukov, Mervyn A. Sahud, and David J. Kuter. "Thrombopoietin Levels May Predict Responsiveness to Therapy with Thrombopoietin Agonists Among Patients with Immune Thrombocytopenic Purpura,." Blood 118, no. 21 (2011): 3288. http://dx.doi.org/10.1182/blood.v118.21.3288.3288.

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Abstract Abstract 3288 INTRODUCTION: Thrombopoietin (TPO) is the major regulator of platelet production. In prior clinical studies, thrombopoietin levels have been shown to vary inversely with circulating platelet mass and with the rate of platelet production. Thus, TPO levels may help distinguish between the various disorders of thrombocytopenia. In addition, the introduction of TPO agonists has created an interest in predicting the response of patients to these agents. Determining TPO levels may help predict such treatment responses. METHODS: Sera from 121 patients with a history of abnormal

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Gotlib, Jason, Bing Zhang, Carol D. Jones, et al. "Identification of a Novel Splice Donor Mutation In the Thrombopoietin Gene In a Philippine Family with Hereditary Thrombocythemia." Blood 116, no. 21 (2010): 3086. http://dx.doi.org/10.1182/blood.v116.21.3086.3086.

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Abstract Abstract 3086 Background: Hereditary thrombocythemia (HT) is a rare autosomal dominant disorder related to mutations in either the gene encoding thrombopoietin (THPO), or its receptor MPL. In some cases of HT, mutational involvement of the THPO or MPL genes has been excluded. To date, five HT families with three distinct THPO mutations have been published, including Dutch, Japanese, and Polish pedigrees. In all cases, the mechanism of overproduction of platelets is related to alteration of the 5′ untranslated region (5′ UTR) of the THPO gene which results in enhanced translation of th

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15

Ruf, J., B. Czarnocka, M. Ferrand, F. Doullais, and P. Carayon. "Novel routine assay of thyroperoxidase autoantibodies." Clinical Chemistry 34, no. 11 (1988): 2231–34. http://dx.doi.org/10.1093/clinchem/34.11.2231.

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Abstract This radioimmunoassay was developed for specific and large-scale routine measurement of autoantibodies to thyroperoxidase (TPO), an enzyme recently identified as the thyroid microsomal antigen. Because of the scarcity of purified thyroperoxidase, we did not base the assay on the antigen-coated method but rather on autoantibody inhibition of the binding of labeled TPO to a solid-phase-bound monoclonal antibody to TPO. This assay design ensured highly specific measurements without interference from irrelevant thyroid antigens and autoantibodies. When we used affinity-purified autoantibo

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OKUBO, Michiko, Goshi SHIOTA, and Hironaka KAWASAKI. "Thrombopoietin levels in serum and liver tissue in patients with chronic viral hepatitis and hepatocellular carcinoma." Clinical Science 99, no. 3 (2000): 207–14. http://dx.doi.org/10.1042/cs0990207.

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Thrombocytopenia in liver diseases is considered to be due to splenic platelet pooling and accelerated destruction. Since thrombopoietin (TPO), a regulator of thrombopoiesis, is produced mainly in the liver, decreased production of TPO may account for thrombocytopenia in liver diseases. To address this issue, we measured serum TPO, using a sensitive sandwich ELISA, in 108 patients with chronic viral hepatitis, which included chronic hepatitis (CH) and liver cirrhosis (LC), and hepatocellular carcinoma (HCC), and in 29 normal controls. TPO mRNA in 78 liver samples was examined by reverse transc

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Ameen, Bilal Qays, Rashid Jame, and Mohammed Ibrahim Nader. "Investigating the Association Between Vitamin D and Anti-Thyroid Peroxidase Antibodies in Hypothyroid Iraqi Patients." Advancements in Life Sciences 12, no. 1 (2025): 76. https://doi.org/10.62940/als.v12i1.2363.

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Objective: The aim of this study was to investigate the relationship between vitamin D quantities and anti-thyroid peroxidase antibodies (anti-TPO) in Iraqi hypothyroidism patients and healthy individuals, using statistical analyses including the Cs-T, t-test, and P-values.Methods: This study collected samples from hypothyroidism patients and healthy individuals as the control group. Statistical analyses were conducted using the Cs-T, t-test, and P-values to compare the results of vitamin D quantities and anti-TPO levels between the two groups.Results: The study found no statistically signific

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Xu, Miao, Li Ma, Naadiya Carrim, et al. "Platelet GPIba Is Important for Thrombopoietin Production and Thrombopoietin-Induced Platelet Generation." Blood 126, no. 23 (2015): 12. http://dx.doi.org/10.1182/blood.v126.23.12.12.

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Abstract Background: Platelets are generated from megakaryocytes in the bone marrow and play a key role in hemostasis. GPIba is the major subunit in the GPIb-IX complex expressed on platelets and megakaryocytes (MKs). Deficiency of GPIba results in Bernard Soulier Syndrome (BSS), a severe bleeding phenotype characterized by thrombocytopenia and abnormal platelet morphology. The generation of megakaryocytes and platelets is regulated by the hematopoietic growth factor, thrombopoietin (TPO). In patients with thrombocytopenia, the TPO receptor agonists and recombinant TPO (rTPO) have been used to

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D., Vinoth Kumar, and Aruna R. "Cross sectional study evaluating the correlation of thyroid dysfunction with severity of disease in rheumatoid arthritis." International Journal of Research in Medical Sciences 8, no. 6 (2020): 2074. http://dx.doi.org/10.18203/2320-6012.ijrms20202246.

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Background: The present study was conducted to evaluate the correlation of disease severity in RA and thyroid dysfunction.Methods: The present cross-sectional descriptive study enrolled 164 participants aged 12 years and above diagnosed as having RA. Use of drugs causing thyroid dysfunction, malignancy, diabetes mellitus, systemic hypertension, pregnancy and prior thyroidectomy were the criteria for exclusion. Data was analyzed using R and tests of significance were Chi square test and independent sample t-test and Pearson correlation. Institutional ethics committee approved the study and writ

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Kim, Sang Yoon, and Jung Hyo Ahn. "Clinical Characteristics of Patients with Euthyroid Thyroid-associated Ophthalmopathy." Journal of the Korean Ophthalmological Society 63, no. 9 (2022): 741–46. http://dx.doi.org/10.3341/jkos.2022.63.9.741.

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Purpose: To compare clinical features between thyroid-associated ophthalmopathy (TAO) patients with hyperthyroidism and euthyroidism.Methods: Between September 2015 and January 2021, we enrolled 96 TAO patients with euthyroidism (n = 16) or hyperthyroidism (n = 80). We recorded the age, sex, smoking status, presence of hypertension and diabetes, total follow-up period, unilateral involvement, eyelid edema, lid lag and retraction, clinical activity score (CAS), modified NOSPECS score, exophthalmometry, Hess test, area of extraocular muscles on orbital computed tomography (CT), treatment with sy

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Gautam, Bijaya, Satish Poudel, and Shanti Pokhrel. "Significance of thyroid peroxidase antibodies (anti-TPO antibodies) in patients undergoing thyroid function tests." Journal of Gandaki Medical College-Nepal 17, no. 2 (2024): 111–6. https://doi.org/10.3126/jgmc-n.v17i2.70774.

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Introduction: Thyroid peroxidase (TPO) enzyme is a poorly glycosylated enzyme responsible for the synthesis of the thyroid hormones. TPO antibodies appear where there is tissue destruction in thyroid follicles, thereby making it a good marker for detection of autoimmune thyroid disorders. Thus, this study was conducted to analyze the significance of anti-TPO antibodies in patients undergoing a thyroid function test. Methods: This is a hospital-based cross-sectional study conducted on 235 patients who had undergone thyroid function tests (TFTs) along with anti-TPO. Overnight fasting samples wer

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Anjali, Kumari, Kanak Lata Kumari, and Singh Mamta. "Relationship between Gestational Hypothyroidism and Postpartum Thyroid Dysfunction: A Retrospective Cohort Study." International Journal of Pharmaceutical and Clinical Research 16, no. 5 (2024): 2270–76. https://doi.org/10.5281/zenodo.13173298.

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<strong>Background:</strong> Gestational hypothyroidism is common during pregnancy and after pregnancy. Postpartum thyroid dysfunction may affect mother health and requires continuous monitoring. This study examined thyroid autoantibodies in postpartum thyroid dysfunction and pregnancy hypothyroidism. <strong>Method</strong><strong>:</strong> From December 2021 to May 2023, we conducted a retrospective cohort analysis at NMCH Patna.150 women affected with Gestational hypothyroidism were included in the study. We examined thyroid function tests (TSH, FT4, TPO-Ab) during and after

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Cotton, James, Ying Hong, Emma Hawe, et al. "Rise of circulating thrombopoietin following cardiothoracic surgery is potentiated in patients with coronary atherosclerosis: correlation with a preceding increase in levels of interleukin-6." Thrombosis and Haemostasis 89, no. 03 (2003): 538–43. http://dx.doi.org/10.1055/s-0037-1613385.

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SummaryThrombopoietin (TPO) is the major regulator of platelet production. Plasma levels of TPO are thought to be regulated by its binding to platelets and megakaryocytes. Here we have used a model of cardiac surgery with cardiopulmonary bypass (CBP) to test the possibility that changes in TPO levels are influenced by the presence of coronary artery disease (CAD) and by changes in interleukin-6 (IL-6). After surgery patients with CAD (n = 22) or with normal coronary arteries (n = 11) showed a significant thrombocytopaenia followed by a reactive thrombocytosis. The platelet recovery was precede

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Nemati, Mohadese, Elmira Roshani Asl, Venus Haghshenas, Siamak Rashidi, Zohre Ahmadi, and Bohran Taushih. "Thyroid Dysfunction in Type 1 Diabetes Mellitus in an Iranian Elderly Woman." Asian Pacific Journal of Cancer Care 4, no. 1 (2018): 15–18. http://dx.doi.org/10.31557/apjcc.2019.4.1.15-18.

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Objective: Type 1 Diabetes mellitus (T1DM) and thyroid dysfunction consider as main metabolic and endocrine disorders. In previous studies, individuals with T1DM were susceptible to Thyroid disorders. The prevalence of clinical and subclinical Thyroid dysfunction have noticeable importance especially regarding women and their related stigma. Methods: The presented survey, a case-control study evaluated the thyroid dysfunction among T1DM elderly women referred to diabetes clinic of Tohid Hospital in Sanandaj city. The whole blood samples were attained from all individuals and then the following

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Dieme, A., C. Tressol, E. Bidat, C. Feuillet-Dassonval, and G. Benoist. "Test de provocation orale (TPO) à la noisette cuite en pratique chez l’enfant." Revue Française d'Allergologie 59, no. 2 (2019): 83–89. http://dx.doi.org/10.1016/j.reval.2018.09.005.

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Reena Mariyath, Olasseri K., Manikoth P. Binitha, Vadakke P. Anilakumari, George Biju, Pappinisseri K. Nikhila, and Mann Pradeep. "Association between chronic spontaneous urticaria and thyroid autoimmunity: a case control study from a tertiary care centre." International Journal of Research in Dermatology 3, no. 1 (2017): 64. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20170362.

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<p class="abstract"><strong>Background:</strong> The exact etiology of chronic spontaneous urticaria is unknown in the majority of patients. A subset of chronic spontaneous urticaria can be autoimmune and may be associated with thyroid autoimmunity<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> Serum anti thyroid peroxidase (anti-TPO) antibody level and thyroid function tests (TFT) including triiodothyronine (T3), thyroxine (T4) and thyroid stimulating hormone (TSH) levels were estimated in 100patients with chro

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Huang, Zhen, Min He, and Xiuyin Wang. "Performance verification of Siemens Atellica DL IM1600 automatic immune analyzer detection system: A-TPO and A-TG." Medicine 103, no. 43 (2024): e40168. http://dx.doi.org/10.1097/md.0000000000040168.

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To study the performance of the Siemens Atellica DL IM1600 automatic immune analyzer detection system for thyroid peroxidase antibodies (A-TPO) and anti-thyroglobulin antibodies (A-TG). Perform performance verification based on CNAS and CLSI related documents, including precision, accuracy, reference interval, and linearity. In precision validation, intra-batch imprecision coefficient of variation values of A-TG and A-TPO were 3.60%, 5.40%, and 3.20%, 2.20%, inter-batch imprecision coefficient of variation values were 5.40%, 4.40%, and 5.00%, 2.50%, all within the specified range. In the accur

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Agrawal, Kanhaiya, Preetam Basak, Pinaki Dutta, Rama Walia, Anil Bhansali, and Naresh Sachdeva. "Does Primary BCG Vaccination Prevent Autoimmune Hypothyroid Disease?" Journal of the Endocrine Society 5, Supplement_1 (2021): A838—A839. http://dx.doi.org/10.1210/jendso/bvab048.1711.

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Abstract Autoimmune thyroid disease (AITD) involves autoimmune destruction of thyrocytes marked by the presence of anti-TPO and/or anti-TG antibodies. In autoimmune diseases, an immunomodulatory role of BCG vaccination has been reported with decreased autoantibody production and induction of regulatory T cells (Tregs). We hypothesize that the loss of efficacy of BCG vaccine in adulthood might be associated with the appearance of AITD. To evaluate the protective efficacy of primary BCG vaccination, we assessed the anti-mycobacterial responses, thyroid function, and anti-thyroid autoimmune respo

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Chhaya, Chitra, Rani Rekha, Kumar Amit, and Wakeel Ahmad Md. "Fine Needle Aspiration Cytology Findings of Lymphocytic Thyroiditis and It's Correlation with Thyroid Function Test (TFT)." International Journal of Pharmaceutical and Clinical Research 16, no. 8 (2024): 1740–45. https://doi.org/10.5281/zenodo.13824147.

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This study investigates the relationship between Fine Needle Aspiration Cytology (FNAC) findings and Thyroid Function Tests (TFTs) in patients diagnosed with lymphocytic thyroiditis, commonly referred to as Hashimoto’s thyroiditis. Over the course of a year, the study was carried out on 85 patients. The study was carried out in the department of Pathology, Narayan Medical College and Hospital, Jamuhar, Sasaram. The severity of lymphocytic infiltration was assessed using FNAC, and these results were then compared to the levels of Thyroid Stimulating Hormone (TSH) and anti-thyroid peroxida

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Rosello, Olivier, Federico Solla, Ioana Oborocianu, et al. "Advanced containment methods for Legg-Calvé-Perthes disease: triple pelvic osteotomy versus Chiari osteotomy." HIP International 28, no. 3 (2017): 297–301. http://dx.doi.org/10.5301/hipint.5000569.

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Introduction: The goal of intervention in Legg-Calvé-Perthes disease (LCPD) is to prevent femoral head deformation by containing the head within the acetabulum. Currently, surgical containment methods are the mainstay of treatment, and pelvic osteotomies have been shown to be successful. They include triple pelvic osteotomy (TPO), Salter osteotomy, Chiari osteotomy and shelf procedure. The purpose of this study was to compare clinical and radiologic results for Chiari osteotomy and TPO in LCPD. Methods: 29 children treated between 1980 and 2010 for LCPD in 2 centres were reviewed. 19 underwent

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Cantoni, Silvia, Monica Carpenedo, Maria Gabriella Mazzucconi, et al. "Thrombopoietin Receptor Agonist (TPO-RA) Switch in Adult Primary Immune Thrombocytopenia (ITP) Patients: A Retrospective Collaborative Survey from 8 Italian Hematology Centers." Blood 126, no. 23 (2015): 3462. http://dx.doi.org/10.1182/blood.v126.23.3462.3462.

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Abstract Introduction. Availability of the 2 TPO-RAs Romiplostim (Rom) and Eltrombopag (El) offers an effective treatment option for primary ITP patients (pts). However, some pts are either not responsive or lose response - i.e. desired platelet (plt) count achieved but not sustained over time, or experience wide fluctuations in plt count with either TPO-RA. Adverse events may cause treatment discontinuation. Finally, ptÕs preference may be an important issue considering the different route and timing of administration of the two agents. Availability of two TPO-RAs for clinical use, with diffe

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McIntosh, Bryan J., Norma E. Fox, and Kenneth Kaushansky. "Factors Affecting Thrombopoietin Production from Bone Marrow Stromal Cells." Blood 104, no. 11 (2004): 1280. http://dx.doi.org/10.1182/blood.v104.11.1280.1280.

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Abstract Thrombopoietin (TPO) is the primary regulator of megakaryopoiesis and therefore also the most important determinant of the number of platelets in circulation. The regulation of TPO blood concentration is complex, with at least a significant component mediated by removal and degradation of the hormone by the mature circulating platelet mass. In this way, if the production of TPO were fixed, when the number of platelets rises, an increased amount of TPO is removed from the plasma, resulting in an inverse relationship between platelet counts and TPO concentration. However, several studie

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Geddis, Amy E., Norma E. Fox, and Kenneth Kaushansky. "The C-Mpl Receptor Expressed on Endothelial Cells Does Not Contribute Significantly to the Regulation of Circulating Thrombopoietin (TPO) Levels." Blood 104, no. 11 (2004): 739. http://dx.doi.org/10.1182/blood.v104.11.739.739.

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Abstract Blood levels of TPO, the primary regulator of platelet production, are thought to be regulated primarily by cellular degradation following its binding to, and internalization by its cell surface receptor, c-Mpl. This physiology is supported by in vitro studies, in which TPO can be removed from solution by incubation with platelets, and accounts for the very high levels of circulating TPO in individuals with congenital amegakaryocytic thrombocytopenia (CAMT), as in this disorder there are no c-Mpl receptor-bearing cells to bind and remove the hormone. Previous reports have demonstrated

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Surendranath, Sindhu Panakkaparambil, Anil Palakkaparambil, Suchithra Erath Thadathil, and Shibu Thadathil Sreedharan. "Lipid Profile in Thyroid Autoimmunity - A Study among Reproductive Age Group Females of Central Kerala." Journal of Evolution of Medical and Dental Sciences 10, no. 37 (2021): 3231–36. http://dx.doi.org/10.14260/jemds/2021/656.

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BACKGROUND One of the most common causes of thyroid dysfunction among women is autoimmunity, especially in fertile age group. Thyroid hormone disorders are associated with a number of biochemical abnormalities including dyslipidaemia, metabolic dysfunctions, spontaneous miscarriage, and preterm delivery. Dyslipidaemia is one of the most common metabolic abnormalities present in patients with thyroid disease. The purpose of this study was to find the association between anti-thyroid peroxidase antibody (anti-TPO) and dyslipidaemia in reproductive age group females from Central Kerala. METHODS A

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Adilla, Magfhira Tiara, Ahmad Syauqy, and Diana Nur Afifah. "KANDUNGAN GIZI, DAYA CERNA PATI IN VITRO, DAN PENERIMAAN FORMULASI COOKIES BERBASIS TEPUNG PISANG BATU (Musa balbisiana Colla) DENGAN MODIFIKASI ENZIMATIK [NUTRITIONAL COMPOSITION, IN VITRO STARCH DIGESTIBILITY, AND FORMULATION ACCEPTANCE OF COOKIES BASE." Penelitian Gizi dan Makanan (The Journal of Nutrition and Food Research) 43, no. 2 (2021): 101–11. http://dx.doi.org/10.22435/pgm.v43i2.3351.

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ABSTRACT In this study, the nutritional composition, in vitro starch digestibility, and formulation acceptance of batu banana flour with enzymatic modification cookies were analyzed. Batu banana (Musa balbisiana Colla) contain high resistant starch that can potentially prevent colorectal cancer. Experimental study with 9 groups of sample tested by duplo, namely non-modified batu banana(Tp1), autoclaving-cooling(TP2), enzymatic autoclaving-cooling(Tp3), enzymatic autoclaving-cooling with autoclaving-cooling(Tp4), and wheat flour(Tp5). The substitutions of Tp1, Tp2, Tp3, and Tp4 were 20%(A

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Aydin, Elanur, Hasan Türkez, and Şener Taşdemir. "Anticancer and Antioxidant Properties of Terpinolene in Rat Brain Cells." Archives of Industrial Hygiene and Toxicology 64, no. 3 (2013): 415–24. http://dx.doi.org/10.2478/10004-1254-64-2013-2365.

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Abstract Terpinolene (TPO) is a natural monoterpene present in essential oils of many aromatic plant species. Although various biological activities of TPO have been demonstrated, its neurotoxicity has never been explored. In this in vitro study we investigated TPO’s antiproliferative and/or cytotoxic properties using the 3-(4,5-dimethylthiazol-2-yl)-2,5 diphenyltetrazolium bromide (MTT) test, genotoxic damage potential using the single-cell gel electrophoresis (SCGE), and oxidative effects through total antioxidant capacity (TAC) and total oxidative stress (TOS) in cultured primary rat neuron

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Jilani, S., C. Metz-Favre, L. Guenard, N. Khayath, and F. De Blay. "Hypersensibilité immédiate aux quinolones : intérêt du test de provocation orale (TPO) à la ciprofloxacine." Revue Française d'Allergologie 56, no. 3 (2016): 305. http://dx.doi.org/10.1016/j.reval.2016.02.132.

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Noor, Syeda Fateha, Sharifatun Jannat, Saidul Islam Khan, and Mohammad Abul Kalam Azzad. "Clinical Association of Anti-TPO in Patients with Chronic Urticaria." Journal of Rangpur Medical College 8, no. 2 (2023): 29–33. http://dx.doi.org/10.3329/jrpmc.v8i2.69323.

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Background: Chronic urticaria may occur when the body's immune system attacks its self-tissues. It is a skin condition marked by brief purpuric wheals that last longer than six weeks. Uncertainty surrounds the disease's etiopathogenesis. Autoimmunity and endocrine dysfunction may both be at play, according to the available research. Objective: This study aimed to evaluate if thyroid immunity is statistically linked with chronic urticaria. Methods: This case-control study was held from June 2022 to March 2023 at Department of Dermatology & Venerology in IMCH, Popular diagnostic center and D

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Kalsoom Noor, Habibullah, and Abdul Aziz. "Frequency of anti TPO positive subclinical hypothyroidism in pregnancy." Professional Medical Journal 29, no. 06 (2022): 879–81. http://dx.doi.org/10.29309/tpmj/2022.29.06.6712.

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Objective: To determine the frequency of anti TPO positive subclinical hypothyroidism in pregnancy. Study Design: Cross Sectional Study. Setting: Outpatient Departments of Gynaecology & Obstetrics and Medicine at a Tertiary Care Hospital of Quetta, Pakistan. Period: May 2020 to May 2021. Material & Methods: All the pregnant women of age 18-45 years whose TSH was above 2.5 uIU/ml and less than 10 uIU/ml and Total T4 was between 5.5-16 ug/dl was said to be having subclinical hypothyroidism and is included in the study. Their age, TSH value, anti TPO and history of prior miscarriage was d

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Butta, Nora V., Mayte Álvarez Román, Ihosvany Fernández Bello, et al. "Effects Of Thrombopoietin Receptor Agonists On APRIL Plasma Levels In Patients With Immune Thrombocytopenia." Blood 122, no. 21 (2013): 1083. http://dx.doi.org/10.1182/blood.v122.21.1083.1083.

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Abstract Introduction Immune thrombocytopenia (ITP) is an example of an autoimmune disease in which B-lymphocytes produce autoantibodies against platelets. Antibody-mediated platelet destruction and suboptimal platelet production leads to a decrease in platelet count. ITP patients with thrombocytopaenia have increased plasma levels of a proliferation-inducing ligand (APRIL), a factor that can promote B-cell maturation and survival. Two new compounds that bind to the thrombopoietin receptor (TPO-R) and activate the megakaryopoiesis have been recently approved for the treatment of chronic ITP as

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Scanlon, Vanessa M., Maria Kochugaeva, Betty M. Lawton, et al. "Single-Cell Tracking By Time Lapse Imaging Confirms Thrombopoietin Promotes Megakaryocytic-Erythroid Progenitor Self Renewal, but Does Not Instruct Lineage Commitment." Blood 138, Supplement 1 (2021): 3270. http://dx.doi.org/10.1182/blood-2021-154360.

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Abstract The molecular mechanisms underlying lineage commitment of stem and progenitor cells have implications for deriving specific cell types in vitro for regenerative medicine purposes. Current approaches to derive transfusable amounts of erythrocytes and platelets fall short of producing physiologically relevant amounts of each cell type. Thrombopoietin (TPO), commonly used in culture systems to increase platelet yield from cultured megakaryocytes, increases megakaryocyte (Mk) numbers and promotes platelet production. With the goal of generating adequate quantities of transfusion products

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Oztop, Nida, Semra Demir, Derya Unal, et al. "Predictive factors of recurrence after omalizumab cessation in the elderly with urticaria: A real-life study." Allergy and Asthma Proceedings 43, no. 6 (2022): 519–28. http://dx.doi.org/10.2500/aap.2022.43.220068.

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Background: There are no well-defined data that help predict the recurrence risk of urticaria after omalizumab cessation in elderly patients with chronic spontaneous urticaria (CSU). Objective: We aimed to evaluate the effectiveness and safety of omalizumab and to determine the possible predictive factors for recurrence after omalizumab cessation in the elderly with CSU. Methods: A total of 193 patients with CSU treated with omalizumab were included and divided into two groups according to age: group 1, ages 18‐64 years (n = 127), and group 2, ages ≥ 65 years (n = 66). Demographics, clinical f

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Serikbayeva, A. A., O. D. Rymar, L. V. Shcherbakova, and Z. B. Tauesheva. "Hormonal, biochemical parameters and blood microelement levels in young women with subclinical hypothyroidism combined with thyroid peroxidase antibody positivity." Therapist’s Bulletin 64, no. 3 (2024): 20–29. http://dx.doi.org/10.31550/2712-8601-vt-2024-3-3.

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Many studies have been devoted to investigating the relationship between subclinical hypothyroidism (SH), thyroid gland (TG) autoimmunity, and blood trace elements; however, the data presented in these studies are often contradictory. Aim of study. To identify the factors associated with SH in combination with the presence of Anti-thyroid peroxidase antibody (TPO-Ab). Design. Single-center, observational, single-cohort, cross-sectional, and uncontrolled study. Materials and Methods. This study analyzed 859 women aged 18–45 with SH and without TG dysfunction. Based on thyroid function and TPO-A

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Voytsekhovskiy, V. V., T. V. Esenina, V. A. Krivutsa, E. A. Filatova, and N. A. Fedorova. "Treatment of patients with COVID-19-associated immune thrombocytopenia in real clinical practice." Bulletin Physiology and Pathology of Respiration, no. 87 (April 3, 2023): 115–23. http://dx.doi.org/10.36604/1998-5029-2023-87-115-123.

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Aim. Demonstration of three clinical cases of immune thrombocytopenic purpura (ITP) that developed during the pandemic of a novel coronavirus infection (COVID-19) from the personal practice of the authors.Materials and methods. A brief review of the literature on the diagnosis and differential diagnosis of COVID-19-associated ITP is presented. Three clinical observations of this pathology are given.Results. In two situations, thrombocytopenia developed after severe COVID-19-associated pneumonia. In one case, ITP was diagnosed after a viral infection; PCR test for COVID19 was negative. A young

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Minxuri, Dorina, Anila Mitre, Silva Bino, Entela Kostrista, and Kejsi Hysaj. "SCREENING TESTS FOR THYROID DYSFUNCTION; IS TSH SUFFICIENT?" LIFE: International Journal of Health and Life-Sciences 7 (November 15, 2021): 111–22. http://dx.doi.org/10.20319/lijhls.2021.7.111122.

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There are different recommendations on how to screen for thyroid gland problems and TSH is the most ordered test. Anti TPO antibodies are usually tested when TSH is not within the normal range, but their presence before TSH changes has not been appreciated. This study aims to evaluate the role of anti-TPO and thyroid ultrasound for the early detection of thyroid pathologies, especially in the subclinical phase. This is a cross-sectional study in 458 individuals (80% females and 20% males). Thyroid laboratory tests and thyroid ultrasound was done. Statistical analysis was performed to assess th

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Mariotti, Stefano, Giuseppe Barbesino, Patrizio Caturegli, et al. "False negative results observed in anti-thyroid peroxidase autoantibody determination by competitive radioimmunoassays using monoclonal antibodies." European Journal of Endocrinology 130, no. 6 (1994): 552–58. http://dx.doi.org/10.1530/eje.0.1300552.

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Mariotti S, Barbesino G, Caturegli P, Atzeni F, Manetti L, Marinò M, Grasso L, Velluzzi F, Loviselli A, Pinchera A, Martino E. False negative results observed in anti-thyroid peroxidase autoantibody determination by competitive radioimmunoassays using monoclonal antibodies. Eur J Endocrinol 1994;130:552–8. ISSN 0804–4643 Objective: Anti-thyroid peroxidase autoantibody (anti-TPO) and anti-thyroid microsomal antibody (anti-M) are strictly related, but discrepancies are sometimes observed. The aim of this study was to assess the incidence and to identify the causes of these discrepancies. Design

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Silitonga, Andi Jaihutan, and Hiace Vega Fernando Siahaan. "PENGGUNAAN TOEFL PRATICE ONLINE SEBAGAI LAYANAN PEMBELAJARAN DAN UJI TEST TOEFL BAGI PARA MAHASISWA DI UNIVERSITAS DARMA AGUNG." PKM Maju UDA 3, no. 3 (2022): 43. http://dx.doi.org/10.46930/pkmmajuuda.v3i3.2595.

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Di Indonesia, ketika ada orang berbicara masalah nilai TOEFL, hampir bisa dipastikan apa yang mereka maksud adalah TOEFL yang bentuk PBT. Jarang dari mereka yang berbicara masalah CBT dan bahkan iBT. Banyak sekali orang di sekitar kita yang belum tahu kalau Test TOEFL juga ada yang format komputer (CBT) dan bahkan internet (iBT). Hal ini bisa jadi dikarenakan keterbatasan informasi ataupun ketidakingintahuan lebih jauh mengenai TOEFL. TOEFL Practice Online (TPO) adalah tes online untuk TOEFL iBT, dibuat dan dikembangkan oleh layanan pengujian platform online. TPO dapat diikuti di rumah, di sek

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Karam, Wissam, Anas Alqam, Ryan Ashkar, et al. "Outcomes of rituximab as treatment for immune thrombocytopenic purpura in patients who have failed steroids or IVIG: A retrospective study in a community practice." Journal of Clinical Oncology 42, no. 16_suppl (2024): e23256-e23256. http://dx.doi.org/10.1200/jco.2024.42.16_suppl.e23256.

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e23256 Background: Immune thrombocytopenic purpura (ITP) is a challenging disorder with multiple treatment options. The 2019 American Society of Hematology guidelines outline treatment recommendations for ITP which include intravenous immunoglobulin (IVIG) and steroids as first-line, with Thrombopoietin receptor agonists (TPO-RAs) and Rituximab as second-line agents. They favor TPO-RAs over Rituximab but suggest that the choice should be individualized. In this study, we explore the rate and duration of response to Rituximab as a second-line agent for ITP. We also analyze relapse rates and res

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Pokharel, Sunil. "Cause of Hypothyroidism in Post Iniversal Salt Iodization era in Nepal." Journal of Diabetes and Endocrinology Association of Nepal 3, no. 1 (2019): 10–15. http://dx.doi.org/10.3126/jdean.v3i1.24059.

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Introduction: Iodine deficiency remains the most common cause of hypothyroidism worldwide, but in areas of iodine sufficiency autoimmune disease (Hashimoto’s thyroiditis) is most common. After implementation of Universal Salt Iodization (USI) to control Iodine Deficiency Disorder(IDD), Nepal is heading towards iodine sufficiency but the prevalence of clinical and subclinical hypothyroidism is still high. So this study was done to find out either chronic autoimmune thyroiditis is the cause of clinical hypothyroidism in post universal salt iodization era of Nepal by measuring Anti-TPO antibody.&

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Abdulsada, Ayaat Abbas, and Hadeel Jabbar Neama. "Association of TPO Gene (rs 2048722) Polymorphisms and Serum Level of Thyroid Hormones with Papillary Thyroid Cancer." Al-Rafidain Journal of Medical Sciences ( ISSN 2789-3219 ) 6, no. 2 (2024): 124–30. http://dx.doi.org/10.54133/ajms.v6i2.781.

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Background: Papillary thyroid carcinoma (PTC) is the most prevalent form of thyroid cancer, making up about 80% of cases. It is influenced by both genetic and environmental factors, making it the most prevalent form of thyroid cancer. Objective: Determine the connection between PTC and polymorphisms in the thyroid peroxidase gene (TPO, rs2048722) as a risk factor, as well as the changes in thyroid hormone serum levels. Methods: The study involved 52 PTC patients and 48 healthy controls. We looked into the link between a type of TPO polymorphism and the risk of getting PTC by finding and genoty

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