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De, Vlaemynck Thijs. "Study of the effect of solvent and molecular weight of TQ1 on the morphology of TQ1:PC60BM and TQ1:PC70BM spin coated systems." Thesis, Karlstads universitet, Institutionen för ingenjörs- och kemivetenskaper (from 2013), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-69361.
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Pasquier, Marie. "STUDY OF HANSEN SOLUBILITY PARAMETERS OFPC60BM, F8, TQ1 AND N2200." Thesis, Karlstads universitet, Institutionen för ingenjörs- och kemivetenskaper (from 2013), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-69358.
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Lundin, Lisa. "Solvents and solvent blends for the polymers TQ1 and N2200." Thesis, Karlstads universitet, Institutionen för ingenjörs- och kemivetenskaper (from 2013), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-74693.
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Abstract The solubility of polymers depends on how well the parameters of the polymers and solvents used resemble each other. The more similar the parameters are, the more likely the polymers are to be dissolved. Hansen´s solubility parameters (HSP) tells us how dispersion forces, polar forces and hydrogen bonding influences the structure of the polymers and thereby their solubility. To be able to manufacture effective organic polymer solar cells in the future, we need more knowledge of how polymers and organic solvents interact with each other. This is an essay on how you could gather more knowledge of how primarily the polymer Poly{[N,N′-bis(2-octyldodecyl)-naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5′-(2,2′-bithiophene)} , (N2200), but also the polymer Poly[2,3-bis-(3-octyloxyphenyl) quinoxaline-5,8-diyl-alt-thiophene-2,5-diyl], (TQ1) dissolves in different organic solvent blends. It is also a test on using the computer software Hansen´s Solubility Parameters in Practice (HSPiP), to estimate the HSP:s for the polymers and the polymer blend. The HSPiP was good at estimating the Hansen solubility parameters for the solubility test on N2200. The software´s drawing tool in the do it yourself- part (DIY) that is used to create a structure code-string (SMILES) for the polymer, did not work as well in this project. The Optimizer in HSPiP made good suggestions of organic solvent blends for N2200 and TQ1, that dissolved the polymers. o-Xylene and tetrahydronaphthalene were the solvents that dissolved N2200 in the solubility test in 24 h and 50 ֯C and among the organic solvent blends it was toluene/1-methylnaphthalene, tetrahydronaphthalene/methyl acetate, tetrahydronaphthalene/o-Xylene and tetrahydronaphthalene/2-methyltetrahydrofuran that were able to dissolve the polymers in the concentrations of 10.0 mg/ml. N2200 dissolved very well up to 10.0 mg/ml in the calculated solvent blends but on the other hand, the samples became very viscous at that concentration and hardly fluent, if fluent at all. It was more difficult to find organic solvent blends that could dissolve N2200 than it was for TQ1. TQ1 dissolved in all solvent ratios that dissolved N2200.Sammanfattning Löslighet hos polymerer beror på hur löslighetsparametrarna hos polymeren och det lösningsmedel man använder, liknar varandra. Ju mer löslighetsparametrarna liknar varandra, desto bättre löser sig polymeren i lösningsmedlet. Hansen´s löslighetsparametrar (HSP) talar om hur dispersionskrafter, polära krafter och vätebindningar påverkar strukturer hos polymerer och därigenom deras löslighet. För att kunna tillverka effektiva organiska polymera solceller i framtiden, behöver vi mer kunskap i hur polymerer och organiska lösningsmedel interagerar med varandra. Detta är en uppsats i hur man kan gå tillväga för att ta reda på mer om hur främst polymeren Poly{[N,N′-bis(2-octyldodecyl)-naphthalene-1,4,5,8-bis(dicarboximide)-2,6-diyl]-alt-5,5′-(2,2′-bithiophene)} , (N2200), men också polymeren Poly[2,3-bis-(3-octyloxyphenyl) quinoxaline-5,8-diyl-alt-thiophene-2,5-diyl], (TQ1) löser sig i olika blandningar av organiska lösningsmedel. Det är också ett försök till att använda dataprogrammet, Hansen´s Solubility Parameters in Practice (HSPiP), för att estimera löslighet hos polymererna och polymerblandningen. Det visade sig att HSPiP, var bra på att estimera Hansens löslighetsparametrar för löslighetstestet på N2200. Programmets ritverktyg i DIY (do it yourself/gör det själv), för att skapa SMILES-kod (kod för den ritade molekylens struktur) för polymeren, visade sig vara mindre bra. Optimeraren i HSPiP visade sig kunna föreslå organiska lösningsmedelsblandningar för N2200 och TQ1 som kunde lösa polymererna. o-Xylene och tetrahydronaftalen var de som löste N2200 i löslighetstestet på 24 h med 50 ֯C och av blandningarna var det toluen/1-methylnaftalen, tetrahydronaftalen/metylacetat, tetrahydronaftalen/o-Xylene och tetrahydronaftalene/2-metyltetrahydrofuran som kunde lösa polymererna i koncentrationer av 10.0 mg/ml. N2200 löste sig bra ända upp till 10.0 mg/ml för de beräknade lösningsmedelsblandningarna men däremot blev proverna väldigt viskösa i den koncentrationen och knappt flytande, om alls flytande. Det var svårare att hitta organiska lösningsmedelsblandningar som fungerade för N2200 medan TQ1 kunde lösa sig i allt som fungerade för N2200.
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Johansson, Jim. "An Investigation of Short Circuits in All-solution Processed and All-organic Solar Cells." Thesis, KTH, Skolan för kemivetenskap (CHE), 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-207027.
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Organic solar cells have shown great promise of becoming a cheaper alternative to inorganic solar cells. Additionally, they can also be made semitransparent. To avoid using expensive indium tin oxide electrodes in organic solar cells the electrodes can be made from conductive polymer, poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS). However, these so-called PEDOT-PEDOT solar cells are prone to short-circuiting. The work behind this thesis thus aimed to find the cause of these short circuits. The initial working hypothesis assumed the hygroscopic PSS in the bottom electrode could attract water across the active layer when the top electrode layer was applied. This would then swell the bottom electrode and cause the active layer to crack leading to short circuits. Accordingly, swelling was investigated as it was suspected to be the main cause of the shorts. This was achieved by coating reflective substrates with different layers from the solar cell, dropping water on top of the stack and then filming the thin film interference effects. SEM, AFM and IR were also used for further analysis. Although the bottom electrode swells, it was found that water does not cause permanent cracking. Instead, the research unveiled that water causes a formation of blisters, which are suspected to be made of PSS. The exact mechanism for the formation of the shorts remains unclear however.
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Medina, Tiago da Silva. "Participação do eixo Th17/IL-27 no controle da infecção experimental com Trypanosoma cruzi." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/17/17147/tde-02052014-160055/.
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Produzida por macrófagos e células dendríticas, a IL-27 é uma citocina heterodimérica capaz de induzir células Tr1 produtoras de IL-10 e consequentemente regular linfócitos Th1, Th2 e Th17, dependendo da doença envolvida. Partindo-se do pressuposto de que a infecção causada por Trypanosoma cruzi normalmente induz miocardite refletida pela migração intensa de linfócitos Th1 para o tecido cardíaco, nós analisamos o papel regulador da IL-27 nesta condição inflamatória. Nós inicialmente verificamos que a IL-27 foi prontamente induzida in vitro em células infectadas com T. cruzi. Para gerar miocardite intensa coordenada por linfócitos Th1, nós polarizamos linfócitos T naïves para o padrão Th1 na ausência de moléculas relacionadas ao perfil Th17 (camundongos IL-17R-/-, IL-23-/- e IL-6-/-). Como esperado, a inflamação cardíaca intensa e o dano tecidual foram observados na ausência das moléculas do padrão Th17, o que contribuiu para a morte prematura dos animais IL-17R-/-, IL-23-/- e IL-6-/-, precisa e notoriamente pela indução da migração excessiva de linfócitos Th1 para o tecido cardíaco via CXCL-9 e CXCL-10. Para explorar os mecanismos pelos quais a IL-27 controla a miocardite induzida pelo T. cruzi, nós encontramos um recrutamento substancial de macrófagos produtores de IL-27 para o tecido cardíaco, o qual foi mediado pelas quimiocinas CCL3 e CCL4 na ausência de moléculas do padrão Th17. Para determinar quais os receptores necessários para a produção de IL-27, nós observamos que macrófagos derivados da medula óssea de camundongos deficientes de TLR4-/-, TLR9-/- e NLRP3-/- aboliram completamente a produção desta citocina após a infecção in vitro com T. cruzi, enquanto o receptor TLR2 foi dispensável. Nós também verificamos que macrófagos produtores de IL-27 suprimiram linfócitos Th1 através da indução de células Tr1 produtoras de IL-10 após a infecção com T. cruzi. Em seguida, nós avaliamos se a IL-27 foi correlacionada com a proteção cardíaca durante a doença de Chagas. Nós observamos níveis séricos elevados de IL-27 tanto em pacientes com a forma clínica indeterminada ou cardíaca leve, enquanto pacientes com cardiomiopatia moderada ou grave produziram níveis reduzidos de IL-27. Neste estudo, nós descrevemos um novo mecanismo regulador desempenhado por macrófagos produtores de IL-27 no controle da miocardite induzida por T. cruzi. Macrófagos produtores de IL-27 podem suprimir processos inflamatórios desencadeados por linfócitos Th1, os principais vilões na doença de Chagas.IL-27 is a heterodimeric cytokine produced by macrophages and dendritic cells known to induce IL-10-producing Tr1 cells and to regulate Th1, Th2, and Th17 lymphocytes, depending on the underlying disease. Because the infection caused by Trypanosoma cruzi normally induces myocarditis mirrored by an outstanding migration of Th1 cells to the heart tissue, we analyzed the regulatory role of IL-27 in this inflammatory condition. We firstly verified that IL-27 was promptly induced by in vitro T. cruzi-infected spleen cells. To generate a robust myocarditis coordinated by Th1 lymphocytes, we polarized lymphocytes to a Th1 pattern by infecting mice in the absence of Th17-related molecules (IL-17R-/-, IL-23-/-, and IL-6-/- mice). As expected, an impressive cardiac inflammation and damage was observed in the absence of Th17-related molecules, leading IL-17R-/-, IL-23-/-, and IL-6-/- mice to the premature death, precisely and notably by inducing an exuberant Th1 migration to the heart tissue via CXCL9 and CXCL10 chemokines. To explore the mechanisms by which IL-27 controls T. cruzi-induced myocarditis, we found a striking recruitment of IL-27-producing macrophages to the heart tissue mediated by increased levels of CCL3 and CCL4 chemokines in the absence of Th17-associated molecules. To gain further insights into the receptors required to IL-27 production, we observed that bone marrow-derived macrophages from TLR4-/-, TLR9-/-, and NLRP3-/- mice completely abolished IL-27 production after in vitro T. cruzi infection, while TLR2 was dispensable. We also verified that IL-27-producing macrophages supressed Th1 lymphocytes by inducing IL-10-producing Tr1 cells after T. cruzi infection. We next assessed whether IL-27 was correlated to cardiac protection during Chagas Disease. We observed augmented serum levels of IL-27 in either patients with indeterminate (asymptomatic) form or mild cardiac form, whereas patients with moderate or severe cardiomyopathy were poor producers of IL-27. Here, we described a novel regulatory mechanism developed by IL-27-producing macrophages in the control of T. cruzi-induced myocarditis. IL-27-producing macrophages can suppress inflammatory processes caused by Th1 lymphocytes, the bona fide culprits of Chagas Disease.
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Sinclair-Williams, M. J. M. "Disability and safety management systems in TQM and non-TQM organisations." Thesis, University of Surrey, 1998. http://epubs.surrey.ac.uk/844353/.
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Historically society has, at various periods in time, protected the health, safety and welfare of those most disadvantaged by using socially based collective mechanisms. Within the United Kingdom the model used to achieve this collective protection has developed from proscription, under the Factories Acts, to a more self-regulatory and risk based approach advocated by Lord Roben's under the Health and Safety at Work etc. Act 1974 and its relevant statutory provisions. The body tasked with providing examples of good practice and regulating the provisions of the Act, The Health and Safety Executive, advocate a management-led model using the principles of total quality management (TQM). This model is one which purports to focus on a systematic and empowered approach by involving all staff in the evaluation and reduction of systematic error within processes throughout the whole organisation. It can be argued that the contemporary disadvantaged are no longer the children of the industrial revolution but are those members of society who seek employment yet are handicapped by society through disability or impairment- the paradigm of disability. This study sought to explore this paradigm of disability and TQM within the context of two contrasting industrial sectors - the engineering and retail sectors. The study sought to break new ground by exploring whether the TQM model, which advocates system totality, reduction in variation and continuous improvement as fundamental principles, does in fact provide improved cognitive adequacy (a construct of institutional responsibility, communication and problem resolution) within the paradigm of disability. The study used a triangulation methodology to collect qualitative data at the individual and institutional level. This involved a number of phases comprising group discussions, focus groups and self-completed questionnaires (n=1135) by economically active disabled, impaired and handicapped individuals and at the organisational level case study analysis (n=8) and self-completed questionnaires (n=2181) by institutional key players. Although the construct of disability is multifaceted, the study concluded that at the individual level a number of factors were perceived to be ranked higher and as such more important to disabled employees in maintaining their health, safety and welfare. These were further classified into 'software' and 'hardware' domains of a safety management system with institutional social support being most important. Social support comprised support, communication and trust and was perceived to be low at the organisational level. At the institutional or organisational level social support can be measured using the theory of cognitive adequacy comprising responsibility, communication and problem resolution. When measured at the organisational level, via the policy domain, cognitive adequacy was once more concluded to be low or absent. These results applied equally to individuals within both the retail and engineering sectors. The study also concluded that, at the organisational level, safety systems which can be categorised as formal did not exist to meet the needs of the disabled within the organisations studied. This was particularly evident at the policy domain level where it was noted that few companies had included provisions for the allocation of specifically defined responsibility and control. However there existed many informal sub-systems which had developed through group dynamics and personal interrelations. In many cases those tasked with operational responsibility were unaware of such sub-systems. There also existed many barriers within the disability paradigm to both the duty holder and disabled employees meeting specific duties under the Health and Safety at Work etc. Act 1974. In particular communication, both verbal and non-verbal, presented the highest ranked barrier to organisations achieving a high cognitive adequacy condition. Each construct was measured using contingency tables and log-linear analysis to determine any association between TQM and non-TQM organisations for the paradigm of disability. Significant differences in data acquisition, performance measurement and problem resolution existed between TQM and Non-TQM organisations. However in relation to the paradigm of disability, the study concluded that the data supported the null hypothesis that, in the context of the paradigm of disability, no significant differences were exhibited between the safety management systems (SMS) of organisations who had adopted TQM and those that had not. Holistically this study has provided a deeper understanding of the complexity of the disabled paradigm and safety provisions at work.
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Burkhard, Carina. "TQM-Trend-Matrix Methode zur prognostischen Analyse unternehmensspezifischer Wirkungen von TQM-Massnahmen /." [S.l.] : [s.n.], 2006. http://se6.kobv.de:8000/btu/volltexte/2007/41.
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Piercecchi, Marco. "Undersökning av affinitet till TS1-218, TS1-2182 och HE1-Q enkelkedjeantikroppar i multicellulära tumörsfäroider cytokeratin 8 för TS1-218, TS1-2182 och HE1-Q enkelkedjeantikroppar i multicellulära tumörsfäroider." Thesis, Karlstads universitet, Institutionen för kemi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-4987.
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In vitro-test för upptäckt och behandling av tumör eller mikrometastaser har de senaste 30 åren gjort stora framsteg tack vare immunokemi och nya framgångsrika cellodlings- tekniker som bättre reproducerar celltillväxt i tre dimensioner (3D) och det omgivande stromat (multicellulär tumörsfäroidodling). TS1-218 scFv (single chain variable fragment) är en monoklonal antikropp som har affinitet till ett protein tillhörande cytoskelettet (cytokeratin). Av TS1-218 har skapats olika varianter (en dimer TS1-2182 och en mutant HE1-Q) med syftet att öka affinitet och retentionstid på platsen för dess verkan. I det här projektet försökte vi att testa och jämföra egenskaper hos alla 3 joderade antikropparna genom att inkubera odlade Hela Hep 2 tumörcellssfäroider med dessa antikroppar. Alla tre antikroppsvarianter visade god förmåga att penetrera sfäroider och att binda deras epitop i cytokeratin 8. Försöken visade att det fanns affinitetsskillnader mellan TS1-218 monomer, dimer och mutant vilket visade sig som olika inbindningsförmåga till sfäroiderna.
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(UPC), Universidad Peruana de Ciencias Aplicadas, Chih Te Chang, and Andreas Whittome. "Chino TI1 - TR214 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623669.
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El curso de Chino 1 es un curso de especialidad en la carrera de traducción e interpretación profesional, de
carácter teórico-práctico dirigido a los estudiantes del tercer ciclo que busca desarrollar las competencias
específicas de segundas lenguas y habilidades interpersonales, basando en el enfoque comunicativo que permite
al alumno comprender información y expresarse de manera oral y escrita acerca de temas cotidianos, de su
entorno personal y de interés general, así como familiarizarse con los aspectos históricos y culturales de China,
utilizando el vocabulario y las estructuras gramaticales básicas del idioma.
El Chino es el idioma más hablado del mundo, es el segundo más utilizado en internet, y la lengua oficial de la
segunda potencia económica mundial, el dominio del chino mandarín forma una ventaja competitiva para un
traductor o intérprete en este mundo globalizado que vivimos actualmente, brinda mayor facilidad para el
acceso a nuevas oportunidades en el desarrollo profesional, ya que la economía, política y cultura de China cada
día se vuelve más importante en el ámbito internacional.
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(UPC), Universidad Peruana de Ciencias Aplicadas, and Cestari Adriana Domenico. "Portugués ti1 - TR83 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623623.
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Descripción: El curso Portugués TI1 es el primer contacto del alumno de Traducción e Interpretación con la
segunda lengua electiva de su elección. Representa el primer nivel para la adquisición del idioma portugués que
le permitirá, a futuro, ser un mediador lingüístico y cultural efectivo para abordar problemáticas, crear acuerdos
e implementar soluciones de manera inmediata en dicho idioma.
Propósito: El curso Portugués TI 1 ha sido diseñado para que el alumno adquiera las competencias necesarias
para alcanzar el nivel A2 (usuario básico) en dicho idioma, según el Marco Común Europeo de Referencias para
Segundas Lenguas. Al trabajar con las competencias generales UPC de Comunicación Oral y Comunicación
Escrita, ambas a un nivel 1 y con la competencia específica Segundas Lenguas de la carrera, a un nivel 1, brinda
al futuro traductor-intérprete una herramienta fundamental para enfrentar los retos en su campo profesional con
eficiencia.
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Huerto, Massaro Fiorella Marisa, and Lafitte Ivette Soto. "Francés TI1 - TR75 201801." Universidad Peruana de Ciencias Aplicadas (UPC), 2018. http://hdl.handle.net/10757/623361.
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El curso Francés TI1 valida el primer nivel de dominio de la lengua francesa (nivel A1 del Marco Comuìn
Europeo de Referencia de las Lenguas) que permite a futuros traductores e intérpretes profesionales
comunicarse en términos básicos en forma oral y escrita en francés para desempeñarse en situaciones
cotidianas, teniendo una base sólida para el desarrollo de la competencia comunicativa en francés a lo largo de
su vida.
El curso de Francés TI1 desarrolla la competencia lingüística y cultural en francés a fin de favorecer el
crecimiento cognitivo, cultural y humano necesarios para futuros traductores e intérpretes profesionales y
propias de un usuario básico que comprende y utiliza expresiones cotidianas de uso muy frecuente a fin de
satisfacer necesidades de tipo inmediato. El curso no tiene prerrequisitos. El curso contribuye directamente al
desarrollo de las competencias generales de Comunicación Oral y Escrita y la competencia específica de
Segundas Lenguas, a un nivel 1.
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Bergereau, Emilie. "Rôle des LT-CD8+ dans l'auto-immunité du SNC : influence des autres effecteurs de l'immunité adaptative." Toulouse 3, 2010. http://thesesups.ups-tlse.fr/1108/.
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La sclérose en plaques est une maladie inflammatoire chronique multifactorielle caractérisée par de nombreux infiltrats inflammatoires (lymphocytes T, lymphocytes B, macrophages activés, cellules de la microglie) et par des lésions focales résultant en une démyélinisation des axones et une perte d'oligodendrocytes. Afin de comprendre le rôle pathogène des LT-CD8+ et l'implication des autres effecteurs de l'immunité adaptative comme les LT-CD4+ auto-réactifs et les auto-Ac, des transferts adoptifs de LT-CD8+ spécifiques de l'Hémaglutinine du virus Influenza (HA) différenciés in vitro en Tc1 spécifiques de HA et/ou de LT-CD4+ spécifiques de HA différenciés in vitro en Th1 ont été réalisés dans les souris MOG-HA (exprimant le néo-auto-antigène exclusivement dans les oligodendrocytes). Il a ainsi pu être évalué les conséquences cliniques et pathologiques de l'inflammation du système nerveux central (SNC). Les résultats obtenus ont montré que le transfert de Th1 seuls ne provoque pas de signes cliniques apparents : pas de perte de poids ni de diminution des performances physiques suite à un effort malgré la présence d'une inflammation (sans démyélinisation) au niveau du SNC. Le transfert de Tc1 seuls induit dans 30% des cas, des pertes de poids ainsi qu'une mobilité réduite et des défaillances motrices. Au niveau histologique, il existe une infiltration massive de LT suite à ce transfert conduisant à une inflammation sévère du SNC et une démyélinisation des axones. Le co-transfert des deux populations aggrave ces signes cliniques et histologiques suggérant une coopération des deux populations lymphocytaires au niveau du SNC. Des analyses complémentaires en cytométrie de flux ont permis de caractériser les cellules immunes qui infiltrent le SNC. Nous avons ainsi pu montrer qu'il existe une différence au niveau de l'activation de la microglie entre les différents types de transfert. En effet, lors du co-transfert Tc1/Th1, il y a une activation très importante de la microglie, des macrophages et un recrutement plus important de cellules dendritiques et de LT au niveau du SNC comparé aux transferts isolés des populations. Dans le même esprit de recherche d'une synergie entre les effecteurs de l'immunité adaptative, des transferts adoptifs de LT-CD8+ spécifiques de HA différenciés in vitro en Tc1 suivis d'injection d'anticorps démyélinisants (anti-MOG) ont été réalisés chez les souris MOG-HA. Cette injection d'anticorps potentialise également le phénotype induit par le transfert de Tc1 seuls. Ceci est associé à un recrutement précoce des molécules du complément au niveau des lésions. Ces travaux ont ainsi permi de conclure en une synergie d'action entre les LT-CD8+ spécifique d'un auto-antigène et d'autres effecteurs de l'immunité adaptotive tels que les LT-CD4+ et les AcMultiple sclerosis is a multifactoriral chronic inflammatory disease characterized by numerous inflammatory infiltrats (T lymphocyte, B lymphocyte, activated macrophages, microglia) and by focal lesions resulting in a demyelination of axons and loss of oligodendrocytes. To understand the pathogenic role of LT-CD8+ and the implication of the other effectors of the adaptive immunity such as auto-reactive CD4+-T cells and auto-Ab, adoptive transfers of CD8+-T cells specific for HA differentiated in vitro in Tc1 and\or CD4+-T cells specific of HA differentiated in vitro in Th1 were performed in mice MOG-HA (expressing the neo-auto-antigen exclusively in oligodendrocytes). We then followed the clinical and pathological consequences of the inflammation of central nervous system (CNS). The obtained results showed that the isolated transfer of Th1 does not provoke visible clinical signs: no weight loss nor decrease of the physical performances during an effort in spite of the presence of an inflammation (without demyelination). The isolated transfer of Tc1 resulted in 30 % of cases in weight loss as well as a reduced mobility. At the histological level, there is a massive infiltration of T cells after this Tc1 transfer leading to a severe inflammation of CNS and a demyelination of axons. The co-transfer of both populations aggravates these clinical and histological signs suggesting a cooperation of both lymphocytes populations in the CNS. Complementary analyses by flow cytometry allowed to characterize the immune cells that had infiltrated the CNS. We were so able to show that there was a difference at the level of the activation of the microglia between the various types of transfer. Indeed, during the co-transfer Tc1 / Th1, an important activation of microglia, macrophages and a more important recruitment of dendritic cells and T cells in the CNS was observed compared to transfers of isolated populations. In the same spirit of research for synergy between the effectors of the adaptive immunity, adoptive transfers of CD8+-T cells specific of HA differentiated in vitro in Tc1 followed by injection of demyelinating antibody ( anti-MOG ) were realized in mice MOG-HA. This injection of antibody also potentialise the phenotype induced by the transfer of Tc1. This is associated with an early recruitment of complement factors at the level of the lesions. So, these works permit to conclude in a synergy between CD8+-T cells specific of an auto-antigene and others effectors of the adaptative immunity such as CD4+-T cells and Ab
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Chiang, Sonnig Sue Whei. "Th1/Th2 imbalance in schizophrenia." Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-35074.
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Hettle, S. J. H. "Expression of TN1/3 transposase." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375435.
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Zelená, Karolína. "Aplikace TQM v hotelovém provozu." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-200153.
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This master thesis is focused on Total Quality Management implementation into Sovereign Hotel Prague. The aim of this thesis is to discover the quality level of this hotel and initiate such arrangments that would lead to longterm sustainability.Therefore there is a complete intern audit realized, that is conducted out of 25 quality checklists with all together 376 evaluation criteria. There are also used reviews from Tripadvisor and Booking.com for evaluation of the quality in hotel Sovereign. The results from the intern audit lead to implementation of TQM in the hotel. The theoretical part is focused on definition of quality, its characters, aspects and possibilities of quality management. It describes the principles of Total Quality Management and its use in hotel business. Facilities, services, organisational structure and market position of Hotel Sovereign is also characterised.
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Piercecchi, Marco. "Undersökning av affinitet till TS1-218, TS1-2182 och HE1-Q enkelkedjeantikroppar i multicellulära tumörsfäroider cytokeratin 8 för TS1-218, TS1-2182 och HE1-Q enkelkedjeantikroppar i multicellulära tumörsfäroider." Thesis, Karlstad University, Division for Chemistry, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-4987.
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In vitro-test för upptäckt och behandling av tumör eller mikrometastaser har de senaste 30 åren gjort stora framsteg tack vare immunokemi och nya framgångsrika cellodlings- tekniker som bättre reproducerar celltillväxt i tre dimensioner (3D) och det omgivande stromat (multicellulär tumörsfäroidodling). TS1-218 scFv (single chain variable fragment) är en monoklonal antikropp som har affinitet till ett protein tillhörande cytoskelettet (cytokeratin). Av TS1-218 har skapats olika varianter (en dimer TS1-2182 och en mutant HE1-Q) med syftet att öka affinitet och retentionstid på platsen för dess verkan. I det här projektet försökte vi att testa och jämföra egenskaper hos alla 3 joderade antikropparna genom att inkubera odlade Hela Hep 2 tumörcellssfäroider med dessa antikroppar. Alla tre antikroppsvarianter visade god förmåga att penetrera sfäroider och att binda deras epitop i cytokeratin 8. Försöken visade att det fanns affinitetsskillnader mellan TS1-218 monomer, dimer och mutant vilket visade sig som olika inbindningsförmåga till sfäroiderna.
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Kazak, Ilkay. "Th1-Th2-Zytokine bei entzündlicher Herzmuskelerkrankung." [S.l.] : [s.n.], 2002. http://www.diss.fu-berlin.de/2002/70/index.html.
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Søvik, Harald. "GeneTUC : Event extraction from TQL logic." Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2006. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-10061.
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As Natural Language Processing systems converge on a high percentage of successful deeply parsed text, parse success alone is an incomplete measure of the ``intelligence'' exhibited by the system. Because systems apply different grammars, dictionaries and programming languages, the internal representation of parsed text is often different from system to system, making it difficult to compare performance and exchange useful data such as tagged corpora or semantic interpretations. This report describes how semantically annotated corpora can be used to measure quality of Natural Language Processing systems. A selected corpus produced by the GENIA project were used as ``golden standard'' (event-annotated abstracts from MEDLINE). This corpus were sparse (19 abstracts), thus manual methods were employed to produce a mapping from the native GeneTUC knowledge format (TQL). This mapping were used to produce an evaluation of events in GeneTUC. We were able to attain a recall of 67% and average precision of 33% on the training data. These results suggest that the mapping is inadequate. On test data, the recall were 28% and average precision 21%. Because events is a new ``feature'' in NLP-applications, there are no large corpora that can be used for automated rule learning. The conclusion is that at least there exists a partial mapping from TQL to GENIA events, and that larger corpora and AI-methods should be applied to refine the mapping rules. In addition, we discovered that this mapping can be of use for extraction of protein-protein interactions.
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Nitek, Kevin W. "Americas [sic] automotive competitiveness and TQM." Online version, 1998. http://www.uwstout.edu/lib/thesis/1998/1998nitekk.pdf.
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Zuccon, Jonathan Venturim. "Supercondutividade em ligas de Ta1-xZrx." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/43/43134/tde-12052016-125023/.
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No presente estudo, amostras policristalinas ricas em Ta e com estequiometrias Ta1-xZrx; x < 0.15; foram preparadas através da mistura apropriada dos elementos metálicos, os quais foram fundidos em forno a arco elétrico sobre uma placa de cobre refrigerada a água e sob atmosfera de argônio de alta pureza. Os padrões de difração de raios-X das ligas, como fundidas (as cast) e tratadas termicamente a 850 °C por 24 h, revelaram a ocorrência de uma estrutura cristalina cúbica de corpo centrada bcc, tipo W, e parâmetros de rede que aumentam suavemente com o aumento do teor de Zr nas ligas. Medidas de susceptibilidade magnética dc, conduzidas nas condições de resfriamento da amostra em campo zero (ZFC) e do resfriamento com o campo magnético aplicado (FC), indicaram que supercondutividade volumétrica é observada abaixo de ~ 5.8, 6.9, 7.0 K em amostras com x = 0.05, 0.08, e 0.10, respectivamente. Essas temperaturas críticas supercondutoras são bastante superiores àquela observada no Ta elementar ~ 4.45 K. Medidas de resistividade elétrica na presença de campos magnéticos aplicados de até 9 T confirmaram a temperatura crítica supercondutora das amostras estudadas. O campo crítico superior Hc2 e o comprimento de coerência E foram estimados a partir dos dados de magnetorresistência. Os valores estimados de Hc2 foram de ~ 0.46, 1.78, 3.85 e 3.97 T, resultando em valores de E ~ 26.0, 13.6, 9.2 e 9.1 nm para as ligas as cast com x = 0.00, 0.05, 0.08 e 0.10, respectivamente. A partir dos dados experimentais do calor específico Cp das ligas, magnitudes estimadas do salto em Cp nas vizinhanças das transições supercondutoras indicaram valores maiores que o previsto pela teoria BCS. Utilizando as equações analíticas derivadas da teoria do acoplamento forte da supercondutividade foi então proposto que o aumento da temperatura de transição supercondutora nas ligas devido a substituição parcial do Ta por Zr está intimamente relacionado ao aumento do acoplamento elétron-fônon, visto que a densidade de estados eletrônicos no nível de Fermi foi estimada ser essencialmente constante através da série Ta1-xZrx com x < 0.10.In the present study, polycrystalline samples of Ta-rich binary alloys with stoichiometry Ta1-xZrx; x < 0.15; were prepared by mixing appropriate amounts of the metallic elements which were arc-melted on a water-cooled hearth under high-purity argon atmosphere. The X-ray diffraction patterns of the as cast alloys and heat treated ones at 850 °C by 24 h revealed the occurrence of the body-centered cubic crystal structure bcc, type W, and lattice parameters that increase slightly with increasing Zr content. Magnetic susceptibility measurements dc, performed in zero-field cooling ZFC and field cooling FC processes, indicated that bulk superconductivity is observed below ~ 5.8, 6.9, and 7.0 K, in samples with x = 0.05, 0.08, and 0.10, respectively. These superconducting critical temperatures are higher than that of ~ 4.45 K found in elemental Ta. Electrical resistivity measurements under applied magnetic fields to 9 T corroborated the superconducting critical temperatures for the samples studied. The thermodynamic upper critical field Hc2 and the coherence length E were estimated from the magnetoresistance data. The estimated values of Hc2 were 0.46, 1.78, 3.85, and 3.97 T, leading to E 26.0, 13.6, 9.2, and 9.1 nm for the as cast alloys with x = 0.00, 0.05, 0.08, and 0.10, respectively. In addition to this, from the results of heat capacity Cp data, jumps in the vicinity of the superconducting transition were estimated and found to be larger than the one expected from the BCS theory. By using analytic equations derived from the strong coupling theory of superconductivity we argued that the enhancement of Tc in alloying Ta with Zr is due to the increase of the electron-phonon coupling, provided that the density of states in the Fermi level was found to be essentially constant in the series Ta1-xZrx; x < 0.10.
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Eriksson, Henrik. "Benefits from TQM for organisational performance." Licentiate thesis, Luleå tekniska universitet, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-18776.
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Total Quality Management (TQM) is sometimes considered as a management system in continuous change and consisting of values, methodologies and tools, the aim of which is to increase external and internal customer satisfaction with a reduced amount of resources. Whether TQM improves the performance of companies has been discussed for several years. One way to work with TQM and its values, methodologies and tools is to apply for and work with a quality award. Today, there are international, national, regional, branch-wise and in-company quality awards. The purpose of this thesis is to evaluate whether and describe how working with quality awards affects the performance of companies. The thesis consists of an extended summary and three appended papers on this subject, each one with a different aim and methodology. Two of the papers study the benefits from in-company quality awards for the performance of units, and one paper studies the financial performance of quality award recipients compared with competitors and branch indices. The main conclusion of the thesis, which strengthens earlier published results, is that working with quality awards affects financial performance positively if companies successfully implement TQM, which is the case for quality award recipients. Moreover, the results of this thesis have not been able to show strong evidence proving that the performance of units which have worked with in-company quality awards, but have not yet successfully implemented TQM, are affected by this work. However, such units experience that working with in-company quality awards has positive effects on the customers as well as the employees.Godkänd; 2002; 20070222 (ysko)
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Elfaituri, Ashref A. "An assessment of TQM implementation, and the influence of organisational culture on TQM implementation in Libyan banks." Thesis, University of Gloucestershire, 2012. http://eprints.glos.ac.uk/2127/.
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TQM has become a competitive strategy for organisations and has been widely implemented throughout the world. Over the previous three decades, there has been a dramatic growth globally in the implementation of total quality management (TQM) in many organisations with the aim of improving the quality of their products and services, and meeting customers‘ needs. Although the literature in the field relates the success of many organisations in the implementation of TQM, it also refers to the fact that there have been some failures or shortcomings and barriers to the implementation of TQM. These failures or barriers to adoption and implementation are due not only to a lack of top management commitment or weak understanding of total quality management, but also encompass organisational cultural factors. The purpose of this research is to assess the level of TQM implementation, and to explore the influence of organisational culture on TQM implementation in Libyan banks. In addition, this research identifies the main obstacles that affect the implementation of TQM in Libyan banks. This study uses both quantitative and qualitative methods to achieve the objectives of the research. A questionnaire was designed to determining the level of TQM implementation in Libyan banks, and to identify the causal relationships between factors, in order to explore the influence of organisational culture on TQM implementation. Complimentary semi-structured interviews were conducted with managers and supervisors to gain a greater understanding of some additional issues with regard to TQM practice and organisational culture. The results of data analysis show that the level of TQM implementation in Libyan banks was low. The competing value framework (CVF) as proposed and tested by Denison and Spreitzer (1991) was used to explore the influence of organisational culture types on TQM implementation factors in Libyan banks. The findings showed that group culture and developmental culture had a positive influence on all TQM implementation factors. In addition, hierarchical culture and rational culture did not have any influence on TQM implementation factors in this context. Moreover, the study revealed that some of the obstacles that affected the achievement of a high level of TQM implementation in Libyan banks were: a lack of top management commitment; a lack of training programmes relating to quality management; and a weak focus on customer expectations and satisfaction. The findings of this study make an original contribution to the academic and practical knowledge of TQM. It is the first exploratory study to have assessed TQM implementation, and to have investigated the influence of organisational culture types on TQM implementation in Libyan banks. Besides presenting some recommendations for Libyan banks, the research offers suggestions for further research in this area.
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Ferndale, Clint, and n/a. "The true worth of TQM to Army - a model for TQM in the Australian Army : prophecy of fallacy?" University of Canberra. Management, 1990. http://erl.canberra.edu.au./public/adt-AUC20060710.104131.
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The philosophy of Total Quality Management (TQM) is
relatively little known in Australia, and does not feature at
policy level in the Australian Army. It has, however, been
adopted by the US Department of Defense (US DoD) and the
Royal Australian Air Force (RAAF), and is being investigated
by the Royal Australian Navy (RAN).
TQM is analyzed as a theory and as an organizational
concept. This is supported by extensive analysis and case
studies from US and Australian organizations. The public and
private sector organizations examined provide indications of
the worth of TQM, guidance for planning and implementation,
and the facility to learn from the experiences of others. TQM
cannot be undertaken without detailed, organizationally specific
preparation and requires pro-active support from the
highest level of the organization.
This paper examines the TQM philosophy and the Australian
Army and proposes a model for the development of TQM as an
integral part of the organizational function of the Army. The
emphasis is on general management, the level that has the
responsibility for structuring and managing the Army in
support of all Army functions.
Research conducted by elements of the US DoD is analyzed
to indicate applicability to the future requirements of the
Australian Army.
The paper argues that general management in the
Australian Army has been affected by organizational changes
over time. A management philosophy is now needed that will
support, into the 21st Century, the values and roles required
by the Army. TQM provides such a basis, and the proposed TQM
Development Model provides in turn a sound basis for further
examination of TQM by the Army.
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Belabbes, Mehdi El. "Les déterminants de la réussite pérenne du management par la qualité totale : cas du groupe CODIM2." Thesis, Corte, 2013. http://www.theses.fr/2013CORT0010.
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Notre thèse repose sur le constat, confirmé par les auteurs et les professionnels, que le management par la qualité totale (TQM) est un mode de gestion centré sur la qualité, visant la rentabilité à long terme par la satisfaction des clients et l'amélioration continue de l'ensemble des processus de production. Notre travail a pour objectif d’explorer les déterminants qui assurent la pérennité de la réussite de ce système managérial. En adoptant un mode exploratoire de recherche basé sur une étude clinique, nous avons choisi le groupe CODIM comme un terrain pour effectuer notre étude de cas. Dans cette perspective, notre question de recherche est formulée de la manière suivante :- Quels sont les déterminants de la réussite pérenne du management par la qualité totale ?Nous avons entrepris de répondre à cette interrogation lors d’une recherche en trois phases :• Une phase de conceptualisation qui comprenait une étude approfondie du concept du management par la qualité totale, fondée sur l’expérience des auteurs et sur la littérature existante, ainsi que l’étude des théories et des pratiques liées au TQM.• La seconde phase visait à élaborer un modèle idéal des déterminants de réussite du management par la qualité totale, concrétisé par l'ensemble des variables explicatives de notre question centrale.• La troisième phase consistait à expérimenter notre modèle théorique et à tester nos hypothèses grâce à une étude qualitative suivie d'une étude quantitativeOur thesis is based on the fact, confirmed by the authors and professionals that the total quality management (TQM) is a management focused on quality, for the long-term profitability by customer satisfaction and improving all continuous production process. Our work aims to explore the determinants that ensure the sustainability of the success of the managerial system. By adopting an exploratory search mode based on a clinical study, we chose the CODIM group as a ground for making our case study. In this context, our research question is formulated as follows :- What are the determinants of long-term success of the total quality management ?We set out to answer this question during a search of three phases:• A conceptualization phase that included a thorough study of the concept of total quality management , based on the authors experience and the literature, and the study of theories and practices related to TQM .• The second phase was to develop an ideal model of the determinants of success in total quality management, embodied by the set of explanatory variables in our central issue.• The third phase was to test our theoretical model and test our hypotheses through a qualitative study followed by a quantitative study
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Todeschini, Anne-Laure. "Etude de la régulation du rétrotransposon Ty1 chez la levure Saccharomyces cerevisiae : activation par la carence en adénine." Paris 7, 2005. http://www.theses.fr/2005PA077083.
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Craft, Michael J. "Successful achievement of TQL in DoN activities." Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1993. http://handle.dtic.mil/100.2/ADA272671.
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Svensson, Magnus. "TQM-based self-assessment in educational organisations." Licentiate thesis, Luleå, 2002. http://epubl.luth.se/1402-1757/2002/12/index.html.
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Yiu, Chung, and 姚忠. "Application of TQM in Hong Kong Government." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31268456.
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Yiu, Chung. "Application of TQM in Hong Kong Government /." Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18836379.
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Xiao, Yanping. "APRIL (TNFSF13) in Th1, Th2 and Th17 Responses." Scholarly Repository, 2009. http://scholarlyrepository.miami.edu/oa_dissertations/335.
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The T cell function of a proliferation inducing ligand (APRIL or TNFSF13) remains unclear. By comparing APRIL-/- mice with wild type (WT) mice, we have investigated the roles of APRIL in Th1, Th2 and Th17 responses. With regard to APRIL in Th1 responses, cultured APRIL-/- CD4+ T cells showed increased IFN-gamma production under non-polarizing, but not under Th1 polarizing, conditions. No difference in antigen-specific IgG2a levels existed between APRIL-/- and WT mice immunized with ovalbumin (OVA) and complete Freund's adjuvant (CFA) which induces Th1 polarization. Our data indicate that APRIL represses Th1 responses only under non-polarizing conditions. As for APRIL in Th2 responses, cultured APRIL-/- CD4+ T cells exhibited enhanced Th2 cytokine production under non-polarizing conditions, and augmented IL-13 production under Th2 polarizing conditions. Upon immunization with OVA and aluminum potassium sulfate (alum) which induces Th2 polarization, APRIL-/- mice responded with an increased antigen-specific IgG1 response. In the OVA-induced allergic lung inflammation model which is mediated by Th2 responses, APRIL-/- mice had significantly aggravated allergic lung inflammation. Accordingly, a decoy receptor-Ig fusion protein, TACI-Ig, treatment to block APRIL in WT mice enhanced allergic lung inflammation. In agreement with the role of APRIL in CD4+ T cells, the transfer of APRIL sufficient, OVA-specific, TCR transgenic CD4+ T (OT-II) cells to APRIL-/- mice restored the suppressive effect of APRIL on allergic lung inflammation. Mechanistically, the expression of c-maf, the IL-4 gene transcription factor, was markedly enhanced in APRIL-/- CD4+ T cells under non-polarizing and Th2 polarizing conditions. Our data suggest that APRIL inhibits Th2 responses and allergic lung inflammation by suppressing IL-4 production in CD4+ T cells via diminished c-maf expression, and by suppressing IL-13 production in CD4+ T cells via an IL-4 independent, IL-13 specific pathway. Regarding APRIL in Th17 responses, the incidence of Th17-mediated collagen-induced arthritis (CIA) in APRIL-/- mice was reduced, in parallel with diminished levels of antigen-specific IgG2a autoantibody and IL-17 production. Our data indicate that APRIL promotes IL-17 production, and that APRIL-triggered signals contribute to arthritis. Our data clearly show that APRIL is important in T cell immunity, inhibitory in Th2 responses and costimulatory in Th17 responses.
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Guimaraes, Miguel Dantas Terra Machado. "An attempt at TQM ( a motivation case study)." Thesis, University of Macau, 1999. http://umaclib3.umac.mo/record=b1636716.
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Wilson, Marya L. "Total quality management (TQM) at the University Centers." Menomonie, WI : University of Wisconsin--Stout, 2006. http://www.uwstout.edu/lib/thesis/2006/2006wilsonm.pdf.
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Rabih, Joyce. "TQM implementation in health care : a proposed framework." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ39974.pdf.
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Harnesk, Roland. "Leadership for co-worker commitment : a TQM approach /." Luleå, 2004. http://epubl.luth.se/1402-1757/2004/33/index.html.
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Schulz, Kerstin Ingrid. "Modulation of Th1 and Th2 type immune responses." Thesis, University of Glasgow, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390690.
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Bolton, Eric C. "Replication of the TY1 retrotransposon in saccharomyces cerevisiae." Available to US Hopkins community, 2002. http://wwwlib.umi.com/dissertations/dlnow/3068121.
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Ganakammal, Satishkumar Ranganathan. "CIS REGULATORY MODULE DISCOVERY IN TH1 CELL DEVELOPMENT." Thesis, Proceeding ISB '10 Proceedings of the International Symposium on Biocomputing ACM New York, NY, USA ©2010 table of contents ISBN: 978-1-60558-722-6 doi>10.1145/1722024.1722039, 2010. http://hdl.handle.net/1805/2678.
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Indiana University-Purdue University Indianapolis (IUPUI)Immune response enables the body to resist foreign invasions. The Inflammatory response is an important aspect in the immune response which is articulated by elements such as cytokines, APC, T-cell and B-cell, effector cell or natural killer. Of these elements, T-cells especially T-helper cells; a sub class of T-cells plays a pivotal role in stimulating the immune response by participating in various biological reactions such as, the transcription regulatory network. Transcriptional regulatory mechanisms are mediated by a set of transcription factors (TFs), that bind to a specific region (motifs or transcription factor binding sites, TFBS), on the target gene(s) controlling the expression of genes that are involved in T-helper cell mediated immune response. Eukaryotic regulatory motifs, referred to as cis regulatory modules (CRMs) or cistrome, co-occur with the regulated gene’s transcription start site (TSS) thus, providing all the essential components for building the transcriptional regulatory networks that depends on the relevant TF-TFBS interactions. Here, we study IL-12 stimulated transcriptional regulators in STAT4 mediated T helper 1 (Th1) cell development by focusing on the identification of TFBS and CRMs using a set of Stat4 ChIP-on-chip target genes. A region containing 2000 bases of Mus musculus sequences with the Stat4 binding site, derived from the ChIP-on-chip data, has been characterized for enrichment of other motifs and, thus CRMs. Our experiments identify some potential motifs, (such as NF-κB and PPARγ/RXR) being enriched in the Stat4 binding sequences compared to neighboring background sequences. Furthermore, these predicted CRMs were observed to be associated with biologically relevant target genes in the ChIP-on-chip data set by meaningful gene ontology annotations. These analyses will enable us to comprehend the complicated transcription regulatory network and at the same time categorically analyze the IL-12 stimulated Stat4 mediated Th1 cell differentiation.
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Ljungström, Martin. "Obstacles towards a work-development-oriented TQM strategy." Licentiate thesis, Luleå tekniska universitet, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:ltu:diva-16873.
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The following thesis originates from the results of a research project carried out in collaboration between Luleå University of Technology and the University of Gävle, with the assistance of nine Swedish and three American companies. Over the past few years, a dramatically increased interest in quality has been observed. This has been particularly noticeable in companies where facilitators, quality catalysts and activity developers are hired; at universities with an expanding curriculum as well as in everyday life when you see or hear the word "quality" in advertisements or conversations. In Sweden, quality-oriented strategies have become one of the leading methods to develop industrial companies, instead of focusing on work organisation and work development that was the main strategy in the later part of the 80s. The major interest of the author is to describe the interaction between quality and work development and the thesis has the following purposes: "Describe how companies can work with TQM and work development" and "Find how different companies can deal with obstacles related to the implementation of a work-development-oriented TQM-strategy". Case studies at Dayco, Ericsson Cables, GM:son Frost and ProfilGruppen are carried out to get a relevant description of how companies can work with TQM and work development. The empirical background together with the theoretical framework, concerning TQM and work development indicates that companies work differently with TQM. Even if the studied companies commit themselves to TQM, and the same core values the differences are obvious in terms of customer focus, continuous improvement and practical TQM approach. An SPC approach is applied to predict the outcome of an implementation process of a work-development-oriented TQM-strategy and to find assignable causes, or obstacles of this process. The findings, obstacles and the elimination of them, are presented under the headings: Management, Continuous improvement, Tools, ISO 9000, Work development, Process orientation and Union. The main obstacles as to work development are limited resources, lack of knowledge and the management's perspective concerning work development. Here, the union traditionally plays a significant role in modulating the public opinion, but in TQM tasks its role as a natural discussion partner is not that clear. This is important since these discussions are a core activity to secure the providence of the employees with the suitable competence and decisive authority to carry out their work in the spirit of TQM. Not only shall everybody be involved in the daily work, but also participate in the improvements and analyses. To reach beyond management programmes without substantial changes in the basic work processes and work organisation, it is important to focus on organisational structure and learning organisation. Continuous improvement as a way of working, lends importance to the concept of learning organisation if a company is to ascend the TQM-ladder. This is the case both in terms of level in the Swedish Quality Award and in terms of fulfilment of the work- development-oriented TQM-strategy presented in this thesis.Godkänd; 2000; 20070318 (ysko)
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Al-Jalahma, Rashed. "Impact of organization culture on TQM implementation barriers." Thesis, Brunel University, 2012. http://bura.brunel.ac.uk/handle/2438/8554.
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This study examines the relationship between organisational culture and TQM implementation barriers to gain a more comprehensive understanding of the factors affecting TQM implementation. For TQM implementation to take root effectively, the critical role of organisational culture is widely recognised. The existence of pitfalls and obstacles (barriers) to implementing TQM is also widely recognized, as is the importance of understanding these TQM implementation barriers. Nevertheless, whilst many TQM implementation models and frameworks have been designed and proposed, no study has been located in the literature that has systematically examined the relationship between organisational culture and TQM implementation barriers. This theoretical lapse in the TQM literature necessitates an investigation of the direction and significance of the relationship which can help in devising more informed TQM implementation models. In this context, a quantitative research methodology was adopted to examine the profiles of organisational culture and of TQM implementation barriers in organisations in Bahrain and to examine the relationship between these variables. Bahrain is presently going through a rapid expansion in quality management system adoption. Accordingly, the research uses four constructs of organisational culture as independent variables and six constructs of TQM implementation barriers identified through the literature as dependent variables. A set of hypotheses was developed describing the expected relationships between these two sets of variables. The study adopted a positivist, deductive approach using an online survey questionnaire to obtain quantitative data for hypothesis testing. The research instrument was assessed for validity and reliability through structured interviews. Responses to the survey were obtained from 325 organisations located in Bahrain. Analysis of Moment Structure (AMOS) version 16.0 was used to test the measurement model using Confirmatory Factor Analysis (CFA), and to test the structural model using Structural Equation Modelling (SEM). Both models showed a very good fit to the data, with good construct validity and reliability. The findings of the study showed that group culture, which is believed to be an ‘ideal’ culture for TQM implementation helps decrease employee barriers, information barriers and customer related barriers as predicted. However group culture wasn’t found to help decrease top management barriers. Rational culture was found to decrease top management barriers as predicted but it wasn’t found to help decrease employee and customer barriers. The findings confirm the significant impact of hierarchical culture in the Bahrain context in decreasing planning and process management barriers. Developmental culture’s potential to lower employee and customer barriers was observed but was not found to be statistically significant. This research makes several contributions in both academic and practical terms. Theoretically, positioning organisational culture as an antecedent of TQM implementation barriers, this study is the first holistic approach that attempts to empirically investigate which type of organisational culture is related to which TQM implementation barriers. Understanding the nature, strength and direction of these relationships can help to inform and support future TQM implementation attempts. Practically, this research will benefit organisations who have not been able to fully realise TQM, or who are in the process of planning the introduction of TQM. The findings of the study can help Bahraini organisations to realise the long term quality objectives of the Bahrain Centre of Excellence’s Vision 2030 programme. Furthermore, the study has contributed a new empirically tested scale for measuring TQM implementation barriers - a valuable tool on its own, or in conjunction with the organisational culture profile assessment tool - for both practitioners wishing to examine their readiness for TQM or progress in creating a TQM ethos, and for future researchers wishing to extend our understanding of the influence of TQM barriers and/or culture on major organisational improvement interventions. It is expected that replication of this study in other countries and regions with different culture and context may help in developing an improved model of TQM implementation. Implications for managers and future research are advanced.
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Kristensen, Tina. "Quantification of thymidine kinase (TK1) mRNA in normal and leukemic cells and investigation of structure-function relationship of recombinant TK1 enzyme /." Roskilde : Department of Life Sciences and Chemistry, Roskilde University, 1996. http://hdl.handle.net/1800/479.
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Kelemen, Mihaela Ligia. "The role of leadership in achieving total quality management in the UK service sector : a multi-paradigm study." Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307211.
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Kandampully, Jaya Anand. "Total quality management through continuous improvement in service industries." Thesis, University of Exeter, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294482.
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Nwabueze, Uche. "An analysis of the feasibility of developing a generic model for the implementation of total quality management within the National Health Service." Thesis, Sheffield Hallam University, 1995. http://shura.shu.ac.uk/3112/.
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This is an exploratory case study evaluating the process of TQM implementation in the 23 TQM demonstration sites in the NHS. These sites were set up in 1989 by the Department of Health as centres of excellence for the implementation of TQM. An earlier study' evaluating TQM in the NHS failed to adequately contextualise the reasons for the argument that orthodox TQM has failed in the NHS. Against this background, it became necessary to carry out an extensive reassessment of TQM initiatives in the NHS. The central thrust of the study involves the identification of: i.the differing modes of implementation of TQM across the sites; ii.the difficulties managers were encountering in the implementation of TQM - barriers to the implementation of TQM; iii.the critical key success factors for the successful implementation of TQM in theNHS; and, iv.based on empirical evidence seeks to determine whether a specific model of TQM is required in the NHS. As Francis Bacon noted, 'if anyone wants to understand nature, he has to study nature rather than base their understanding on Aristotle's postulations of nature. This is because Aristotle did not understand nature, his ideas about nature were not empirically determined'2 Hence, to gain a conceptual understanding of TQM, it is necessary to understand 'implementation' and not base understanding on the outmoded ideas of the Gurus, whose philosophies are not grounded in empirical data. Thus, the TQM literature is inundated with TQM models that are based on anecdotal evidence and the personal prescriptions of TQM writers'. This situation has led to a call by a number of writers' for an empirically determined implementation model for TQM; particularly in the healthcare setting. To determine whether such a model is required in the NHS, this exploratory study used a unique combination of qualitative and quantitative data to sample 23 Quality Managers at the 23 TQM sites in order to provide an accurate rendition of the TQM process in the NHS. The study makes a valid contribution to the quality literature, by contending that TQM has not failed in the NHS as earlier suggested by one stud?, but is yet to be tried. Allegations of failure arise from improper implementation, which is itself symptomatic of the lack of a context-specific model for the implementation of TQM in the NHS. The conclusion was reached from a number of perspectives: (1) the critique of current TQM literature which is based on the personal ideas of quality management proponents (Chapter Three). (2) a reconceptualisation of the implementation of TQM. The study suggests that the traditional paradigms of TQM lack adequate contextualisation. They only provide answers for the "what" of TQM in the form of step-by-step approaches, or of TQM as a vehicle for culture change, without providing the practising manager with the 'how' of the implementation process. This apparent limitation, the author suggests, makes TQM orthodoxy inappropriate to deal with the complexities of the NHS (Chapter Four). (3) the study also found that the suggestions in the literature that the barriers to the implementation of TQM have generic applicability across organisations is a misnomer. In most of the hospitals the difficulties that quality managers were facing were specific to the organisational context (Chapter Five). (4) seventeen critical success factors were identified as valid and specific to the NHS. These factors, unlike the 'Ten Critical Success Factors' identified by Black6 are of equal importance for the implementation of TQM and are not categorised on a scale of importance (Chapter Seven). In the final analysis, the study, as a major contribution to knowledge in the quality management field, provides the first empirically determined context specific model for the implementation of TQM in the NHS. The model represents the first problem specific model validated by the experiences of fifteen quality managers in the NHS. It provides an empirical understanding of the 'nature' of the implementation of TQM within the confines of the British National Health Service. In addition, a measurement framework to monitor the progress of TQM at various stages of the implementation process is offered (Chapter Seven).
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Doherty, William. "Assessment and self-assessment of total quality management in organisations using knowledge-based techniques." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.318764.
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Clark, Michael Colin. "The role(s) of ISO 9000 quality management systems in the management of educational institutions : an empirical and theoretical analysis." Thesis, University of Wolverhampton, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297605.
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Al-Raisi, Abdullah M. "The feasibility of introducing Total Quality Management into Oman Telecommunication Company (OMANTEL)." Thesis, Sheffield Hallam University, 2000. http://shura.shu.ac.uk/19257/.
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Total Quality Management (TQM) and the issues relating to its implementation have been widely discussed and debated in the business and management literature during the last few years, particularly in the West. The implementation of TQM principles, concepts and methods in an organisation has been regarded as a real movement towards transforming its culture and improving its management processes and the quality of its services and products. Nevertheless, available data on TQM implementation within the context of the developing countries are limited or mainly focused on the manufacturing sector. Little research has been carried out on the subject within the service sector, particularly within the telecommunication sector. The issues relating to TQM implementation in this study are investigated within the context of a developing country; namely Oman; more particularly, within the context of the Omani telecommunication sector. Against this background, this study examines the feasibility of introducing TQM into Oman Telecommunications Company (OMANTEL). The study provides an analysis and assesses the extent to which there is a need for TQM implementation in OMANTEL, and the extent to which the company's internal environment is compatible with the tenets of TQM. The study is based on both secondary and primary data analysis. The secondary data are used to delineate the underpinning principles, methods, tools and techniques of TQM and to offer a background to the organisation under investigation. The secondary data were obtained through a survey of TQM literature and the archival data relating to OMANTEL. The primary data were obtained through an empirical study by questionnaire and conducting several interviews within OMANTEL. The primary data obtained are presented to manifest the extent to which it is feasible to introduce TQM in OMANTEL and to offer recommendations that would enhance this feasibility. The secondary data analysis reveals that there are several emerging trends in the Omani telecom sector that entail some changes in OMANTEL. The secondary data analysis reveals that TQM has much to offer to OMANTEL in order to meet those emerging trends. The primary data analysis reveals that there is a limited knowledge and understanding amongst OMANTEL's personnel of TQM and that there is a significant need for TQM implementation in OMANTEL. The primary data analysis reveals that there are some barriers that could be encountered in implementing TQM in OMANTEL; nevertheless, there are some driving forces that could facilitate this implementation. The primary data also reveals that the internal environment of OMANTEL is conductive to implementing the elements, concepts and principles of the proposed TQM framework.
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Al-Zomany, Yasser M. A. "The acceptability of Total Quality Management in the Islamic culture of Yemen." Thesis, University of the West of England, Bristol, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249413.
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Kamradt, Thomas. "Aktivierung und Differenzierung von T-Lymphozyten durch Infektion und Autoimmunität." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2001. http://dx.doi.org/10.18452/13757.
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Klinische, epidemiologische und experimentelle Daten deuten darauf hin, dass Autoimmunkrankheiten wie z.B. rheumatoide Arthritis, multiple Sklerose oder Typ I Diabetes durch Infektionen ausgelöst oder verschlimmert werden können. Bis heute ist jedoch nicht bekannt, welche molekularen und zellulären Mechanismen den Zusammenhang zwischen Infektion und Autoimmunität vermitteln. Eine Hypothese, die diesen Zusammenhang zu erklären versucht, ist die Hypothese der molekularen Mimikry. Dieser Hypothese zufolge sind kreuzreaktive Lymphozyten, die sowohl Selbst- als auch Fremdantigene erkennen, für die Induktion von Autoimmunität verantwortlich. Die Hypothese der molekularen Mimikry erklärt die Kreuzreaktivität von Lymphozyten durch Sequenzhomologie oder Identität von Selbst- und Fremdantigenen. Wir haben diese Hypothese an zwei Modellen, der chronischen Lyme Arthritis und einem Maus Modell der multiplen Sklerose, getestet und dabei festgestellt, dass Kreuzreaktivität von Lymphozyten weitaus häufiger ist als bis vor kurzem noch vermutet wurde. Wir konnten weiterhin zeigen, dass nicht die Primärstruktur sondern definierbare strukturelle Motive die Ursache für die Kreuzerkennung von Selbst- und Fremdpeptiden sind, und das Kreuzreaktivität in den seltensten Fällen von pathogenetischer Relevanz ist. Die Vorstellung, immunologische Kreuzreaktivität zwischen einem definierten mikrobiellen Antigen und einem definierten Selbstantigen sei für die Pathogenese von Autoimmunkrankheiten verantwortlich, ist also zu einfach. Der zweite Schwerpunkt dieser Arbeit ist die immunologische Analyse eines von uns charakterisierten Th2-spezifisch exprimierten Moleküls, T1/ST2. Wir konnten zeigen, dass T1/ST2 auf Th2, nicht jedoch Th1-Zellen exprimiert wird; dass die Expression von T1/ST2 ex vivo die Lokalisation aktueller Th2-Antworten widerspiegelt; und dass T1/ST2 von funktioneller Bedeutung für die Th2 Zellen ist: Kreuzvernetzung des T1/ST2 Moleküls durch einen T1/ST2-spezifischen monoklonalen Antikörper induziert Proliferation und die Produktion von Typ 2 Zytokinen. In vivo läßt sich durch Applikation des löslichen Antikörpers gegen T1/ST2 die pathogene Th2-Immunantwort im Mausmodell von Asthma modulieren. T1/ST2 ist also ein Kandidat für die gezielte immunmodulatorische Therapie Th2-dominierter Erkrankungen wie Asthma und Allergie.Clinical, epidemiological, and experimental data suggest that infections can sometimes trigger or exacerbate autoimmune diseases such as multiple sclerosis, type I diabetes, or rheumatoid arthritis. To date, the molecular and cellular mechanisms leading from infection to autoimmunity have not been defined. The molecular mimicry hypothesis proposes that crossreactive lymphocytes that recognize both self- and microbial antigens are key factors in the pathogenesis of autoimmunity. According to the molecular mimicry hypothesis, sequence identity or marked sequence similarity between self- and microbial antigens is the cause of such crossreactivity. We have examined the molecular mimicry hypothesis systematically in two different models: treatment-resistant Lyme arthritis and experimental autoimmune encephalitis (EAE). The major findings were: i) crossreactivity at the level of peptide recognition by T cells is far more frequent than previously expected; ii) structural criteria rather than sequence similarity determine cross-recognition; iii) immunoregulatory mechanisms normally prevent pathogenic effects mediated by crossreactive lymphocytes. Thus, the idea that crossrecognition of a defined microbial peptide and a particular self-peptide would explain autoimmunity is most likely too simple. The other major topic of this work was the immunological analysis of T1/ST2, a Th2-specific molecule that we characterized. Here, we could show that T1/ST2 is expressed on Th2 but not Th1 cells. Furthermore, T1/ST2 expression can be used to identify sites of ongoing Th2 reactions directly ex vivo. Most importantly, T1/ST2 is important for Th2 effector functions: crosslinking of T1/ST2 via a T1/ST2-specific monoclonal antibody induces proliferation and type 2-cytokine production. In vivo, administration of the soluble antibody against T1/ST2 ameliorates the immunological parameters of bronchial hyperreactivity in a murine model of asthma. Thus, T1/ST2 is a candidate target for therapeutic immunomodulation of diseases such as allergy and asthma.
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Boloko, Titus Machuene. "An evaluation of total quality management in the chemical industry / Titus Machuene Boloko." Thesis, North-West University, 2009. http://hdl.handle.net/10394/4778.
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Globally, there are great efforts made by organisations to improve effectiveness and systems to remain competitive in ever-changing business markets. Total quality management (TOM) has become a philosophy that most companies adopt once they reach a state where it would like to have a system where all efforts are made to satisfy customers or add value to customer experiences. An investigation was done at a South African chemical company to ascertain if important philosophies (continuous improvement, customer focus and winning with people) of TOM, which are found to be related to some of the company values, are taken seriously at all levels of the company.
The company received a number of complaints from customers about the quality of service and goods supplied and it is of utmost importance to investigate if the concept of
TOM is practiced effectively by this company since the implementation of the TOM
programme. The study conducted has shown that the company understands the concept of quality and the impact of quality on customer satisfaction. TOM is useful when it is implemented at all levels in a company and was indeed found to be implemented on all company levels in this company. Management support, employee improvement, employee empowerment, process improvement, training and development, cleanliness and organisation, teamwork as well as customer focus are the TOM practices that were found to be highly rated within the company. Responses showed that management communication should be improved to ensure that everyone in the organisation is fully informed about all developments. From the results, it was concluded that the foundation of effective TOM is being practiced by the company except in a few minor cases and, therefore, more focus should be placed on those cases.Thesis (M.B.A.)--North-West University, Vaal Triangle Campus, 2010
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Kayser, Anke N. "Stoffflüsse in Escherichia coli TG1 unter aeroben, glucoselimitierten Bedingungen." [S.l. : s.n.], 1999. http://deposit.ddb.de/cgi-bin/dokserv?idn=956676243.
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