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Journal articles on the topic 'Traceless Linkers'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Gibson (née Thomas), Susan E., Neil J. Hales, and Mark A. Peplow. "Chromium carbonyl complexes as novel traceless linkers." Tetrahedron Letters 40, no. 7 (1999): 1417–18. http://dx.doi.org/10.1016/s0040-4039(98)02623-9.

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2

Reitz, Allen B. "ChemInform Abstract: Recent Advances in Traceless Linkers." ChemInform 30, no. 52 (2010): no. http://dx.doi.org/10.1002/chin.199952265.

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3

Zaragoza, Florencio. "New Sulfur- and Selenium-Based Traceless Linkers—More than just Linkers?" Angewandte Chemie International Edition 39, no. 12 (2000): 2077–79. http://dx.doi.org/10.1002/1521-3773(20000616)39:12<2077::aid-anie2077>3.0.co;2-d.

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4

Sui, Binglin, Chen Cheng, Mingming Wang, Elijah Hopkins, and Peisheng Xu. "Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer." Advanced Functional Materials 29, no. 50 (2019): 1906433. http://dx.doi.org/10.1002/adfm.201906433.

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5

Zaragoza, Florencio. "ChemInform Abstract: New Sulfur- and Selenium-Based Traceless Linkers - More Than Just Linkers?" ChemInform 31, no. 37 (2000): no. http://dx.doi.org/10.1002/chin.200037278.

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6

Aioub, Allison G., Cody J. Higginson, and M. G. Finn. "Traceless Release of Alcohols Using Thiol-Sensitive Oxanorbornadiene Linkers." Organic Letters 20, no. 11 (2018): 3233–36. http://dx.doi.org/10.1021/acs.orglett.8b01093.

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7

Núñez-Villanueva, Diego, and Christopher A. Hunter. "Molecular replication using covalent base-pairs with traceless linkers." Organic & Biomolecular Chemistry 17, no. 44 (2019): 9660–65. http://dx.doi.org/10.1039/c9ob02336d.

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8

Haensch, Veit G., Toni Neuwirth, Johannes Steinmetzer, et al. "Metal‐Free Aryl Cross‐Coupling Directed by Traceless Linkers." Chemistry – A European Journal 25, no. 70 (2019): 16068–73. http://dx.doi.org/10.1002/chem.201903582.

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9

Bräse, Stefan, and Stefan Dahmen. "Traceless Linkers-Only Disappearing Links in Solid-Phase Organic Synthesis?" Chemistry - A European Journal 6, no. 11 (2000): 1899–905. http://dx.doi.org/10.1002/1521-3765(20000602)6:11<1899::aid-chem1899>3.0.co;2-m.

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10

Bernardes, Gonçalo J. L., Martina Steiner, Isabelle Hartmann, Dario Neri, and Giulio Casi. "Site-specific chemical modification of antibody fragments using traceless cleavable linkers." Nature Protocols 8, no. 11 (2013): 2079–89. http://dx.doi.org/10.1038/nprot.2013.121.

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11

Brase, Stefan. "ChemInform Abstract: New Linkers for Solid Phase Organic Chemistry. Multidirectional (Multifunctional), Backbone Amide, and Traceless Linker." ChemInform 32, no. 22 (2010): no. http://dx.doi.org/10.1002/chin.200122281.

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12

Lei, Eric K., and Shana O. Kelley. "Delivery and Release of Small-Molecule Probes in Mitochondria Using Traceless Linkers." Journal of the American Chemical Society 139, no. 28 (2017): 9455–58. http://dx.doi.org/10.1021/jacs.7b04415.

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13

He, Maomao, Jie Li, Hesong Han, et al. "A traceless linker for aliphatic amines that rapidly and quantitatively fragments after reduction." Chemical Science 11, no. 33 (2020): 8973–80. http://dx.doi.org/10.1039/d0sc00929f.

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14

Kim, Chul-Bae, Chul-Hee Cho, Min-Jy Jo, and Kwang-Yong Park. "Solid-Phase Synthesis of Unfunctionalized Arenes Via the Traceless Cleavage of Sulfonate Linkers." Bulletin of the Korean Chemical Society 32, no. 10 (2011): 3655–59. http://dx.doi.org/10.5012/bkcs.2011.32.10.3655.

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15

Pomplun, Sebastian, Christopher R. Shugrue, Adeline M. Schmitt, Carly K. Schissel, Charlotte E. Farquhar, and Bradley L. Pentelute. "Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release." Angewandte Chemie International Edition 59, no. 28 (2020): 11566–72. http://dx.doi.org/10.1002/anie.202003478.

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16

Gil, Carmen, and Stefan Bräse. "Traceless and multifunctional linkers for the generation of small molecules on solid supports." Current Opinion in Chemical Biology 8, no. 3 (2004): 230–37. http://dx.doi.org/10.1016/j.cbpa.2004.04.004.

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17

Pomplun, Sebastian, Christopher R. Shugrue, Adeline M. Schmitt, Carly K. Schissel, Charlotte E. Farquhar, and Bradley L. Pentelute. "Secondary Amino Alcohols: Traceless Cleavable Linkers for Use in Affinity Capture and Release." Angewandte Chemie 132, no. 28 (2020): 11663–69. http://dx.doi.org/10.1002/ange.202003478.

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18

Zheng, Yiwu, Yang Shen, Xiaoting Meng, Yaqi Wu, Yibing Zhao, and Chuanliu Wu. "Stabilizing p ‐Dithiobenzyl Urethane Linkers without Rate‐Limiting Self‐Immolation for Traceless Drug Release." ChemMedChem 14, no. 12 (2019): 1196–203. http://dx.doi.org/10.1002/cmdc.201900248.

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19

Comely, Alex C., Susan E. Gibson (née Thomas), and Neil J. Hales. "Polymer supported cobalt carbonyl complexes as novel traceless alkyne linkers for solid-phase synthesis." Chemical Communications, no. 20 (1999): 2075–76. http://dx.doi.org/10.1039/a906048k.

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20

Guo, Yahui, Yue Zhang, Zhanghao Niu, and Yongfang Yang. "Stimuli-responsive biohybrid nanogels with self-immolative linkers for protein protection and traceless release." Colloids and Surfaces B: Biointerfaces 184 (December 2019): 110526. http://dx.doi.org/10.1016/j.colsurfb.2019.110526.

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21

Lee, Violet Eng Yee, Zhi Chiaw Lim, Suet Li Chew, and Wee Han Ang. "Strategy for Traceless Codrug Delivery with Platinum(IV) Prodrug Complexes Using Self-Immolative Linkers." Inorganic Chemistry 60, no. 3 (2021): 1823–31. http://dx.doi.org/10.1021/acs.inorgchem.0c03299.

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22

Paio, Alfredo, Alessio Zaramella, Rafael Ferritto, Nadia Conti, Carla Marchioro, and Pierfausto Seneci. "Solid-Supported Benzotriazoles: Synthetic Auxiliaries and Traceless Linkers for the Combinatorial Synthesis of Amine Libraries1." Journal of Combinatorial Chemistry 1, no. 4 (1999): 317–25. http://dx.doi.org/10.1021/cc990012k.

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23

Sui, Binglin, Chen Cheng, Mingming Wang, Elijah Hopkins, and Peisheng Xu. "Drug Delivery: Heterotargeted Nanococktail with Traceless Linkers for Eradicating Cancer (Adv. Funct. Mater. 50/2019)." Advanced Functional Materials 29, no. 50 (2019): 1970338. http://dx.doi.org/10.1002/adfm.201970338.

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24

Craig, Donald, Michael J. Robson, and Simon J. Shaw. "Traceless Linkers for Solid-phase Synthesis. Homo- and Hetero-Diels-Alder Reactions of o-Quinodimethanes." Synlett 1998, no. 12 (1998): 1381–83. http://dx.doi.org/10.1055/s-1998-1968.

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25

Rigby, James H., та Mikhail A. Kondratenko. "Solid-phase C–C and C–O bond forming reactions using ‘Traceless’ π-arene–chromium linkers". Bioorganic & Medicinal Chemistry Letters 12, № 14 (2002): 1829–31. http://dx.doi.org/10.1016/s0960-894x(02)00268-8.

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26

Paio, Alfredo, Rafael Ferritto Crespo, Pierfausto Seneci, and Manuela Ciraco. "Solid-Supported Benzotriazoles. 2. Synthetic Auxiliaries and Traceless Linkers for the Combinatorial Synthesis of Unsymmetrical Ureas." Journal of Combinatorial Chemistry 3, no. 4 (2001): 354–59. http://dx.doi.org/10.1021/cc000108a.

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27

Kroll, Friedrich E. K., Richard Morphy, David Rees, and David Gani. "Resin-immobilised benzyl and aryl vinyl sulfones: New versatile traceless linkers for solid-phase organic synthesis." Tetrahedron Letters 38, no. 49 (1997): 8573–76. http://dx.doi.org/10.1016/s0040-4039(97)10291-x.

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28

Mincheva, Zoia, Fabien Bonnette, and Olivier Lavastre. "Ionic Liquid Supports Stable Under Conditions of Peptide Couplings, Deprotections and Traceless Suzuki Reactions." Collection of Czechoslovak Chemical Communications 72, no. 3 (2007): 417–34. http://dx.doi.org/10.1135/cccc20070417.

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Ionic liquid supports (ILS) functionalized with carboxylic, alcoholic or amino groups were synthesized, based on 1-methylimidazolium and pyridinium cations, and bromide, chloride, iodide and tetrafluoroborate anions. These reactive ionic liquids were fully characterized by NMR and HRMS. Ionic liquids based on 1-(6-aminohexyl)-3-methylimidazolium iodide have been used in the conditions of peptide chemistry such as coupling and deprotection reactions. A method for attaching (bromophenyl)silanes to the ionic liquid supports was also developed to introduce traceless linkers. An ionic liquid with attached bromobenzene was reacted with ArB(OH)2 under the Suzuki cross-coupling conditions and the resulting compound was cleaved by bromodesilylation with Br2/pyridine to give the substituted products in good yields. The substrate loading of the ILS is high and can be tuned to between 2.5 and 5.0 mmol/g.

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29

Lee, Younghee, and Richard B. Silverman. "Silicon-based aromatic transferring linkers for traceless solid-phase synthesis of aryl-, polyaryl-, and heteroaryl-containing compounds." Tetrahedron 57, no. 25 (2001): 5339–52. http://dx.doi.org/10.1016/s0040-4020(01)00457-4.

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30

May, Peter J., Mark Bradley, David C. Harrowven, and David Pallin. "A new method of forming resin bound thioesters and their use as ‘traceless’ linkers in solid phase synthesis." Tetrahedron Letters 41, no. 10 (2000): 1627–30. http://dx.doi.org/10.1016/s0040-4039(99)02345-x.

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31

Kawanami, Toshio, Laura R. LaBonte, Jakal Amin, et al. "A novel diclofenac-hydrogel conjugate system for intraarticular sustained release: Development of 2-pyridylamino-substituted 1-phenylethanol (PAPE) and its derivatives as tunable traceless linkers." International Journal of Pharmaceutics 585 (July 2020): 119519. http://dx.doi.org/10.1016/j.ijpharm.2020.119519.

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32

Lee, Kyung Joo, and Kim D. Janda. "Traceless solid-phase synthesis of 5-benzoylbenzimidazoles." Canadian Journal of Chemistry 79, no. 11 (2001): 1556–61. http://dx.doi.org/10.1139/v01-138.

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A traceless linker strategy for the solid-supported synthesis of 5-benzoylbenzimidazoles has been developed. A benzyl cyanide functional group was linked to 2% divinylbenzene cross-linked polystyrene through a dimethylsilyl linker. Coupling with 5-chloro-2-nitroaniline followed by oxidative decyanation gave benzophenone 11 as a key intermediate in an efficient one-pot reaction procedure. After reduction of the nitro group and oxidative cyclization with a variety of aldehydes in the presence of DDQ, a series of polymer-supported benzimidazoles was produced. Final traceless cleavage of the arylsilane linker with TBAF provided a small library of 5-benzoylbenzimidazoles.Key words: solid-support, traceless linker, arylsilane, 5-benzoylbenzimidazole.

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33

Takahashi, Takashi. "Nucleophilic Substitutions on MultipinTM Systems Linked with a Traceless Linker." Synlett 1998, no. 11 (1998): 1261–63. http://dx.doi.org/10.1055/s-1998-1935.

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34

Wang, Rong, Funing Yan, Dengli Qiu, et al. "Traceless Cross-Linker for Photocleavable Bioconjugation." Bioconjugate Chemistry 23, no. 4 (2012): 705–13. http://dx.doi.org/10.1021/bc200343u.

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35

Depaix, Anaïs, Jean-Yves Puy, Béatrice Roy, and Suzanne Peyrottes. "New insights for the preparation of cytidine containing nucleotides using a soluble ether-linked polyethylene glycol support." New Journal of Chemistry 42, no. 20 (2018): 16441–45. http://dx.doi.org/10.1039/c8nj03753a.

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36

Pourbaix, Christelle, François Carreaux, Bertrand Carboni, and Hervé Deleuze. "Boronate linker for ‘traceless’ solid-phase synthesis." Chemical Communications, no. 14 (2000): 1275–76. http://dx.doi.org/10.1039/b003487h.

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37

Zitterbart, Robert, Nadja Berger, Oliver Reimann, et al. "Traceless parallel peptide purification by a first-in-class reductively cleavable linker system featuring a safety-release." Chemical Science 12, no. 7 (2021): 2389–96. http://dx.doi.org/10.1039/d0sc06285e.

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A first-in-class reductively cleavable linker system that enables parallel and traceless purification of peptides through a safety-release is introduced with three linker types and showcased by rapid production of 20 personalized neoantigen peptides.

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38

Wilsdorf, M., D. Schmidt, M. P. Bartetzko, et al. "A traceless photocleavable linker for the automated glycan assembly of carbohydrates with free reducing ends." Chemical Communications 52, no. 66 (2016): 10187–89. http://dx.doi.org/10.1039/c6cc04954k.

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A traceless photocleavable linker for automated glycan assembly provides access to complex carbohydrates with free reducing ends, as demonstrated with the successful preparation of nine plant cell wall-related oligosaccharides.

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39

Maier, Kevin, and Ernst Wagner. "Acid-Labile Traceless Click Linker for Protein Transduction." Journal of the American Chemical Society 134, no. 24 (2012): 10169–73. http://dx.doi.org/10.1021/ja302705v.

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40

Gayo, Leah M., and Mark J. Suto. "Traceless linker: Oxidative activation and displacement of a sulfur-based linker." Tetrahedron Letters 38, no. 2 (1997): 211–14. http://dx.doi.org/10.1016/s0040-4039(96)02256-3.

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41

Ciolli, Christopher J., Sean Kalagher, and Peter J. Belshaw. "TRAM Linker: A Safety-Catch Linker for the Traceless Release of Acrylamides." Organic Letters 6, no. 12 (2004): 1891–94. http://dx.doi.org/10.1021/ol049711i.

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42

Horton, James R., Louise M. Stamp, and Anne Routledge. "A photolabile ‘traceless’ linker for solid-phase organic synthesis." Tetrahedron Letters 41, no. 47 (2000): 9181–84. http://dx.doi.org/10.1016/s0040-4039(00)01644-0.

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43

Plunkett, Matthew J., and Jonathan A. Ellman. "A Silicon-Based Linker for Traceless Solid-Phase Synthesis." Journal of Organic Chemistry 60, no. 19 (1995): 6006–7. http://dx.doi.org/10.1021/jo00124a005.

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44

Stieber, Frank, Uwe Grether, and Herbert Waldmann. "An Oxidation-Labile Traceless Linker for Solid-Phase Synthesis." Angewandte Chemie International Edition 38, no. 8 (1999): 1073–77. http://dx.doi.org/10.1002/(sici)1521-3773(19990419)38:8<1073::aid-anie1073>3.0.co;2-y.

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45

Li, Zhengong, Bheemashankar A. Kulkarni, and A. Ganesan. "A selenide linker for “traceless” solid-phase organic synthesis." Biotechnology and Bioengineering 71, no. 2 (2000): 104–6. http://dx.doi.org/10.1002/1097-0290(2000)71:2<104::aid-bit1000>3.0.co;2-7.

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46

Hejesen, Christian, Lars K. Petersen, Nils Jakob V. Hansen, and Kurt V. Gothelf. "A traceless aryl-triazene linker for DNA-directed chemistry." Organic & Biomolecular Chemistry 11, no. 15 (2013): 2493. http://dx.doi.org/10.1039/c3ob27504c.

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47

Mun, Han-Seo, and Jin-Hyun Jeong. "Synthesis of silicon traceless linker for solid-phase reaction." Archives of Pharmacal Research 27, no. 4 (2004): 371–75. http://dx.doi.org/10.1007/bf02980075.

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48

Stieber, Frank, Uwe Grether, and Herbert Waldmann. "Development of the Traceless Phenylhydrazide Linker for Solid-Phase Synthesis." Chemistry - A European Journal 9, no. 14 (2003): 3270–81. http://dx.doi.org/10.1002/chem.200304820.

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49

Pan, Yijun, and Christopher P. Holmes. "A Traceless Perfluoroalkylsulfonyl (PFS) Linker for the Deoxygenation of Phenols." Organic Letters 3, no. 17 (2001): 2769–71. http://dx.doi.org/10.1021/ol0163732.

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50

Hioki, Hideaki, Kimihito Matsushita, Miwa Kubo, and Mitsuaki Kodama. "Combinatorial Synthesis of Benzothiazoles and Benzimidazoles Using a Traceless Aniline Linker." Journal of Combinatorial Chemistry 8, no. 4 (2006): 462–63. http://dx.doi.org/10.1021/cc0600472.

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