Relevant bibliographies by topics / Trained immunity

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Trained immunity'

Author: Grafiati
Published: 4 June 2021
Last updated: 26 July 2025

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Journal articles on the topic "Trained immunity"

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Arneth, Borros. "Trained innate immunity." Immunologic Research 69, no. 1 (2021): 1–7. http://dx.doi.org/10.1007/s12026-021-09170-y.

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Bird, Lucy. "Targeting trained immunity." Nature Reviews Immunology 19, no. 1 (2018): 2–3. http://dx.doi.org/10.1038/s41577-018-0097-0.

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Cortes-Perez, Naima G., Alejandra de Moreno de de Moreno de LeBlanc, Jorge G. Gomez-Gutierrez, Jean Guy LeBlanc, and Luis G. Bermúdez-Humarán. "Probiotics and Trained Immunity." Biomolecules 11, no. 10 (2021): 1402. http://dx.doi.org/10.3390/biom11101402.

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The characteristics of innate immunity have recently been investigated in depth in several research articles, and original findings suggest that innate immunity also has a memory capacity, which has been named “trained immunity”. This notion has revolutionized our knowledge of the innate immune response. Thus, stimulation of trained immunity represents a therapeutic alternative that is worth exploring. In this context, probiotics, live microorganisms which when administered in adequate amounts confer a health benefit on the host, represent attractive candidates for the stimulation of trained i
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Jauregui, Paula. "Trained immunity across organs." Nature Immunology 25, no. 9 (2024): 1509. http://dx.doi.org/10.1038/s41590-024-01958-y.

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van der Heijden, Charlotte D. C. C., Marlies P. Noz, Leo A. B. Joosten, Mihai G. Netea, Niels P. Riksen, and Samuel T. Keating. "Epigenetics and Trained Immunity." Antioxidants & Redox Signaling 29, no. 11 (2018): 1023–40. http://dx.doi.org/10.1089/ars.2017.7310.

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Bird, Lucy. "Trained immunity by HSCs." Nature Reviews Immunology 20, no. 5 (2020): 276–77. http://dx.doi.org/10.1038/s41577-020-0299-0.

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Bekkering, Siroon, Jorge Domínguez-Andrés, Leo A. B. Joosten, Niels P. Riksen, and Mihai G. Netea. "Trained Immunity: Reprogramming Innate Immunity in Health and Disease." Annual Review of Immunology 39, no. 1 (2021): 667–93. http://dx.doi.org/10.1146/annurev-immunol-102119-073855.

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Traditionally, the innate and adaptive immune systems are differentiated by their specificity and memory capacity. In recent years, however, this paradigm has shifted: Cells of the innate immune system appear to be able to gain memory characteristics after transient stimulation, resulting in an enhanced response upon secondary challenge. This phenomenon has been called trained immunity. Trained immunity is characterized by nonspecific increased responsiveness, mediated via extensive metabolic and epigenetic reprogramming. Trained immunity explains the heterologous effects of vaccines, which re
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Velikova, Tsvetelina, Issa El Kaouri, Konstantina Bakopoulou, et al. "Mucosal Immunity and Trained Innate Immunity of the Gut." Gastroenterology Insights 15, no. 3 (2024): 661–75. http://dx.doi.org/10.3390/gastroent15030048.

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Mucosal immunity and trained innate immunity of the gut play a pivotal role in maintaining intestinal homeostasis and defending against microbial pathogens. This review provides an overview of the mechanisms underlying mucosal immunity and the concept of trained innate immunity in the gut. We discuss the interaction between gut microbiota and the host immune system, highlighting the role of epithelial cells, dendritic cells, and innate lymphoid cells, as well as the novel concept of trained innate immunity and its role in perpetuating or attenuating gut inflammation. We also comment on the cur
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Hanb, Chaofeng. "Metabolic basis of trained immunity." American Journal of Biomedical Science & Research 4, no. 2 (2019): 62–64. http://dx.doi.org/10.34297/ajbsr.2019.04.000762.

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Geckin, Büsranur, Friedrich Konstantin Föhse, Jorge Domínguez-Andrés, and Mihai G. Netea. "Trained immunity: implications for vaccination." Current Opinion in Immunology 77 (August 2022): 102190. http://dx.doi.org/10.1016/j.coi.2022.102190.

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Dissertations / Theses on the topic "Trained immunity"

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Schrum, Jacob E. "Pathways Involved in Recognition and Induction of Trained Innate Immunity by Plasmodium falciparum." eScholarship@UMMS, 2017. https://escholarship.umassmed.edu/gsbs_diss/917.

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Malarial infection in naïve individuals induces a robust innate immune response, but our understanding of the mechanisms by which the innate immune system recognizes malaria and regulates its response remain incomplete. Our group previously showed that stimulation of macrophages with Plasmodium falciparum genomic DNA (gDNA) and AT-rich oligodeoxynucleotides (ODNs) derived from this gDNA induces the production of type I interferons (IFN-I) through a STING/TBK1/IRF3-dependent pathway; however, the identity of the upstream cytosolic DNA receptor remained elusive. Here, we demonstrate that this IF
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Schrum, Jacob E. "Pathways Involved in Recognition and Induction of Trained Innate Immunity by Plasmodium falciparum." eScholarship@UMMS, 2008. http://escholarship.umassmed.edu/gsbs_diss/917.

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Malarial infection in naïve individuals induces a robust innate immune response, but our understanding of the mechanisms by which the innate immune system recognizes malaria and regulates its response remain incomplete. Our group previously showed that stimulation of macrophages with Plasmodium falciparum genomic DNA (gDNA) and AT-rich oligodeoxynucleotides (ODNs) derived from this gDNA induces the production of type I interferons (IFN-I) through a STING/TBK1/IRF3-dependent pathway; however, the identity of the upstream cytosolic DNA receptor remained elusive. Here, we demonstrate that this IF
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Jeljeli, Maxime Adrien Mohamed. "«Trained immunity» et rôle de la mémoire macrophagique dans l'immunomodulation des maladies fibro-inflammatoires." Electronic Thesis or Diss., Université Paris Cité, 2020. http://www.theses.fr/2020UNIP5081.

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Les maladies fibroinflammatoires sont un groupe hétérogène de pathologies pouvant impacter des organes tels que la peau, le foie, les poumons et l'appareil digestif et engager le pronostic vital. Malgré un large spectre étiologique, la dérégulation de la réponse immune innée avec une inflammation exacerbée et chronique reste l'élément majeur de leur pathogénie. Récemment, il a été démontré que des cellules de l'immunité innée, tels que les macrophages, sont capables d'acquérir une sorte de mémoire immunologique après une première exposition antigénique et de réagir différemment à une deuxième
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Adams, Kevin Douglas. "Innate Immune Cell Phenotypes Are Dictated by Distinct Epigenetic Reprogramming." BYU ScholarsArchive, 2018. https://scholarsarchive.byu.edu/etd/7700.

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The innate immune system is the first line of host defense against external exposures. During these initial encounters, antigen presenting cells - specifically monocytes and macrophages - modulate further inflammatory responses. Macrophages exist along a spectrum of phenotypic programs; on the inflammatory M1 end they enhance immune activity while on the anti-inflammatory M2 end they suppress further immune activation. Furthermore, within M2 macrophages there exist many subpopulations, namely M2a and M2d, each with specific roles during infection or exposure. We sought to compare the epigeneti
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Palgen, Jean-Louis. "Characterization of the innate immunity elicited by vaccination and its interactions with adaptive immunity, depending on prime-boost delay." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS146.

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La vaccination est l'un des plus grands progrès réalisés en santé publique. Toutefois, malgré de nombreuses connaissances sur le système immunitaire, de nombreux pans d’ombre empêchent la conception de vaccins contre des pathogènes complexes. Pour pallier ce problème, une meilleure compréhension des modes d'action des vaccins est requise. En particulier, la plupart des vaccins nécessitent plusieurs immunisations pour induire une mémoire immunitaire adaptative au long terme, mais l'impact du délai entre primo-vaccination, induisant une mémoire primaire, et rappel(s) la restimulant pour générer
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Pinaud, Silvain. "Aspects fonctionnel et évolutif de l'immunité mémoire chez les invertébrés : l'escargot vecteur de la Bilharziose intestinale Biomphalaria glabrata comme nouvel organisme modèle ?" Thesis, Perpignan, 2017. http://www.theses.fr/2017PERP0037/document.

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Le clade des invertébrés cristallise en 2017 de grandes problématiques sociétales à la fois économiques et sanitaires. En effet un certain nombre des organismes présent dans ce groupe phylétique sont des vecteurs des grandes pandémies infectieuses telles que le paludisme (Anopheles sp), Zika, Chinkungunya, Fièvre jaune, etc (Aedes sp), Chagas (Triatoma sp) ou encore la bilharziose (Biomphalaria sp, Bulinus sp). La compréhension du système immunitaire de ces organismes vecteurs doit aider la communauté scientifique à proposer des solutions pour réduire la transmission de toutes ces maladies sur
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Tu, Fei. "Roles of Endothelial Cell Heat Shock Protein A12B and β-glucan, a reagent for trained Immunity in the Regulation of Inflammation in Sepsis". Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etd/3792.

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Sepsis is dysregulated host immune response to infection causing life-threatening organ dysfunction. Endothelial cell dysfunction and uncontrolled inflammatory responses are two contributors for sepsis-induced mortality. The crosstalk between endothelial and immune cells plays a critical role in the pathophysiology of sepsis. Therefore, understanding the mechanism of interaction between endothelial and immune cells will provide novel information to develop therapeutic strategies for sepsis. Pathogen associated moleculear patterns (PAMPs) and/or damage associated molecular patterns (DAMPs) prod
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Tu, Fei. "Roles of Endothelial Cell Heat Shock Protein A12B and β-glucan, a reagent for trained Immunity in the Regulation of Inflammation in Sepsis". Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/3792.

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Sepsis is dysregulated host immune response to infection causing life-threatening organ dysfunction. Endothelial cell dysfunction and uncontrolled inflammatory responses are two contributors for sepsis-induced mortality. The crosstalk between endothelial and immune cells plays a critical role in the pathophysiology of sepsis. Therefore, understanding the mechanism of interaction between endothelial and immune cells will provide novel information to develop therapeutic strategies for sepsis. Pathogen associated moleculear patterns (PAMPs) and/or damage associated molecular patterns (DAMPs) prod
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Walachowski, Sarah. "Etude des propriétés immunostimulantes de composés pariétaux de levure sur les macrophages murins et évaluation dans des modèles infectieux." Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30090/document.

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Les ß-glucanes (BG) sont les polysaccharides les plus abondants de la paroi de Saccharomyces cerevisiae. Depuis des millénaires, ils sont utilisés pour leurs propriétés immunostimulantes et leurs potentiels thérapeutiques. L'objectif de ce travail était de caractériser la réponse immunitaire induite par les BG et de comprendre leurs modes d'action sur les macrophages murins en contexte infectieux. Nous avons montré que (i) les extraits de paroi enrichis en BG n'induisent qu'une faible production de cytokines par les macrophages contrairement aux extraits bruts, (ii) la réponse inflammatoire mé
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Blazek, Alisa D. "A Simulated Altitude Device can Improve Endurance Performance without Mucosal Immune System Compromise." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1267567607.

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Books on the topic "Trained immunity"

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Subiza, Jose Luis, Silvia Sánchez-Ramón, Oscar Palomares, and Isabella Quinti, eds. Trained Immunity-based Vaccines. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88971-231-1.

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Rapp, Geoffrey. Sports and American Tort Law. Edited by Michael A. McCann. Oxford University Press, 2017. http://dx.doi.org/10.1093/oxfordhb/9780190465957.013.7.

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The intersection of American tort law and the sports industry has produced some interesting and distinctive jurisprudence. Tort rules are, at times, applied in peculiar ways to the sports industry (and to recreational sports). Some of these are well known to most law students—for instance, the “baseball rule” which, at least for most of the twentieth century, appeared to immunize stadiums and teams from liability for injuries caused by batted balls. Other applications may be surprising even for those trained in law—for instance, a court’s discussion of whether potato sack racing is a contact s
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Fox, Simon, Brian Angus, Angela Minassian, and Thomas Rawlinson. Infection in the Immunocompromised Host (Oxford Specialist Handbook). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198789987.001.0001.

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There is an increasing number of patients who are immunocompromised either by malignancy, new therapies, or infection. This handbook aims to provide a clinically relevant guide for use by specialist trainee and consultant medical staff caring for immunocompromised patients in a hospital setting, including but not limited to the areas of infectious diseases, haematolo-gy, oncology, transplant medicine, HIV and genitourinary medicine, rheumatology, and general medicine. Divided into three sections, the handbook takes both a patient-centred approach, and a pathogen-centred approach. This includes
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Book chapters on the topic "Trained immunity"

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Pal, Sayanti, Zaina Rafiq, Rekha Kumari, et al. "Trained Innate Immunity." In Advances in Experimental Medicine and Biology. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-85340-1_11.

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Fernández, Miguel, and Natalia Elguezabal. "Trained Immunity in Livestock." In Encyclopedia of Livestock Medicine for Large Animal and Poultry Production. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-52133-1_291-1.

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Hajishengallis, George, Xiaofei Li, Ioannis Mitroulis, and Triantafyllos Chavakis. "Trained Innate Immunity and Its Implications for Mucosal Immunity and Inflammation." In Oral Mucosal Immunity and Microbiome. Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-28524-1_2.

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Morrison, Hazel, and Helen McShane. "BCG: Past, Present and Future Direction." In Vaccines for Neglected Pathogens: Strategies, Achievements and Challenges. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-24355-4_8.

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AbstractBacillus Calmette-Guérin (BCG) is a live-attenuated vaccine developed over 100 years ago and remains the only vaccine ever licensed in the fight against tuberculosis (TB). It is one of the most widely used vaccines in the world, having been administered to over four billion people, with another 100 million children vaccinated with BCG every year. Despite this, significant debate exists surrounding its efficacy against TB and its place in routine infant vaccination schedules. Severe side effects following BCG administration are rare but may be seen in those with immune system dysfunctio
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Stroeken, Koen. "Chapter Thirteen: Godwork." In Simplex Society. Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-41115-1_15.

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AbstractAgain we encounter the principle of attaining immunity through contagion. The redemption of Pentecostalist converts rests on seizing the very evil that their new religion combats. Inhabitants of Lubumbashi in the Democratic Republic of the Congo and of Morogoro in Tanzania equally train their intuition and prepare their children for the new era’s tensors.The chapter describes a contest between a Sukuma healer and two pastors. The healer masters the game of healing better because of the frameshift. Yet Pentecostal dogmatism does not prevent ‘clarity’, permitting the convert to reach a s
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Conejero, Laura, Paula Saz-Leal, and José Luis Subiza. "Trained Immunity-Based Vaccines: A Ready-to-Act Strategy to Tackle Viral Outbreaks." In Current Perspectives on Viral Disease Outbreaks - Epidemiology, Detection and Control. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.95765.

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Viral outbreaks have become significant threats to global human public health. New emerging viruses, pathogen mutations, and even the progressive loss of efficacy in some existing vaccines are behind this problem, which is amplified by the rapid virus spread given the ease of current mobility. Taking into account that these outbreaks arise in the absence of conventional effective vaccines, alternative approaches based on trained (innate) immunity are being considered. This immunity is dependent on a functional reprogramming of innate immune cells, leading to an enhanced nonspecific response to
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Novakovic, Boris, Nicole L. Messina, and Nigel Curtis. "The Heterologous Effects of Bacillus Calmette-Guérin (BCG) Vaccine and Trained Innate Immunity." In The Value of BCG and TNF in Autoimmunity. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-814603-3.00006-9.

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"Benjamin Colman: Some Observations on Receiving the SMALL-POX by Ingrafting or Inoculating." In Schlager Anthology of Early America. Schlager Group Inc., 2022. https://doi.org/10.3735/9781935306672.book-part-084.

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In April 1721, residents of Boston, Massachusetts, suffered an outbreak of smallpox. The disease was feared because it had a high mortality rate and left most survivors terribly scarred. In response to the epidemic, a Boston clergyman, Benjamin Colman, wrote a pamphlet titled Some Observations on Receiving the SMALL-POX by Ingrafting or Inoculating. He wrote at a time when there were few trained doctors and when clergyman, likely the most highly educated men in their communities, tended to be deeply involved in medical care. His pamphlet presented his observations on a new way of attacking sma
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Roselli, Marianna, Raffaella Canali, Alberto Finamore, Andrea Ghiselli, and Chiara Devirgiliis. "Immune System, Gut Microbiota and Diet: An Interesting and Emerging Trialogue." In Immunology of the GI Tract [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.104121.

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The present chapter provides a comprehensive overview of the multifaceted links connecting the immune system, the intestinal microbiota, and the diet, covering also some recent, less explored, and emerging topics such as the “trained immunity” and the immune cell metabolic activity. The main characteristics of the innate and adaptive immune system are described, as well as the gut-associated lymphoid tissue (GALT). Gut microbiota structure and function are also presented. Particular emphasis is given to the diet as a modulator of the microbiota-immune system crosstalk, focusing on the impact o
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Teja, Samanthula Surya, Ravi Chovatia, Arya Singh, Samad Sheikh, and Amom Mahendrajit. "IMPORTANT SHRIMP VIRAL DISEASES IN AQUACULTURE AND THEIR CONTROL." In Futuristic Trends in Aquaculture. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/nbennurch196.

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Aquaculture, particularly shrimp production, has experienced rapid growth, surpassing the capture fishery, and has become a vital global industry meeting the growing demand for seafood. However, the practices involved in shrimp farming, such as displacement from natural environments, high-density stocking, exposure to stress, and transportation, create conditions conducive to pathogenic infections, leading to viral pandemics. The sustainability of shrimp aquaculture hinges on the establishment of more efficient and bio secure facilities that cultivate specific pathogen-free (SPF) shrimp, genet
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Conference papers on the topic "Trained immunity"

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Sieczkarek, Krzysztof, Bartłomiej Nagórny, Tomasz Warzyński, Adam Maćkowiak, Michał Rokossowski, and Radosław Szczepański. "Innovative Immunity Testing Method of Train Detection Systems to Magnetic Fields coming from passing Railway Rolling Stock." In 2024 IEEE International Symposium on Electromagnetic Compatibility, Signal & Power Integrity (EMC+SIPI). IEEE, 2024. http://dx.doi.org/10.1109/emcsipi49824.2024.10705615.

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Voth, S. B., K. Madera, M. S. Gwin, et al. "Cytoprotective Amyloids Function in Endothelial Trained Immunity and Biofilm Prevention." In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5254.

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Tran, K., J. Downey, and M. Divangahi. "Cross-Protection of BCG Vaccination in Influenza Infection: Trained Adaptive Immunity?" In American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a6531.

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Cavalli, G., M. Gresnigt, T. Nemkov, et al. "P087 The anti-inflammatory cytokine interleukin 37 is an endogenous inhibitor of trained immunity." In 39th European Workshop for Rheumatology Research, 28 February–2 March 2019, Lyon, France. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2018-ewrr2019.76.

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Cavalli, Giulio, Mark Gresnict, Rob Arts, et al. "THU0010 THE ANTI-INFLAMMATORY CYTOKINE INTERLEUKIN 37 IS AN ENDOGENOUS INHIBITOR OF TRAINED IMMUNITY." In Annual European Congress of Rheumatology, EULAR 2019, Madrid, 12–15 June 2019. BMJ Publishing Group Ltd and European League Against Rheumatism, 2019. http://dx.doi.org/10.1136/annrheumdis-2019-eular.3008.

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Markova, A. Yu, та L. G. Kondratyeva. "СREATION OF RECOMBINANT MYCOBACTERIAL STRAINS EXPRESSING HSPA14". У XI МЕЖДУНАРОДНАЯ КОНФЕРЕНЦИЯ МОЛОДЫХ УЧЕНЫХ: БИОИНФОРМАТИКОВ, БИОТЕХНОЛОГОВ, БИОФИЗИКОВ, ВИРУСОЛОГОВ, МОЛЕКУЛЯРНЫХ БИОЛОГОВ И СПЕЦИАЛИСТОВ ФУНДАМЕНТАЛЬНОЙ МЕДИЦИНЫ. IPC NSU, 2024. https://doi.org/10.25205/978-5-4437-1691-6-88.

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TLR are known as the main receptors on the surface of innate immune cells and involved in the training of these cells. A plasmid containing the TLR agonist gene, HSPA14, was obtained to create recombinant mycobacterial strains expressing trained immunity activators. Mycobacteria were transformed by this plasmid, cell lysates were analyzed using western blot.
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Lv, Yinyin. "IDDF2024-ABS-0296 Maximizing the therapeutic potential of trained immunity in DSS-induced colitis management." In Abstracts of the International Digestive Disease Forum (IDDF), Hong Kong, 10 – 11 August 2024. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2024. http://dx.doi.org/10.1136/gutjnl-2024-iddf.120.

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Conejero Hall, Laura, Karla Montalbán, Ana Cogollo, et al. "Late Breaking Abstract - Management of RRTIs in children with the Trained Immunity-based Vaccine MV130: A retrospective study." In ERS International Congress 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/13993003.congress-2023.pa4476.

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Conejero Hall, Laura, Karla Montalbán, Ana Cogollo, et al. "Late Breaking Abstract - MV130, a Trained Immunity-based Vaccine, in the prevention of RRTIs in adults: A retrospective study." In ERS International Congress 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/13993003.congress-2023.pa1107.

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Purcell, Anthony, and Ciaran Eising. "Classification of electromagnetic interference induced image noise in an analog video link." In 24th Irish Machine Vision and Image Processing Conference. Irish Pattern Recognition and Classification Society, 2022. http://dx.doi.org/10.56541/zanb2627.

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With the ever-increasing electrification of the vehicle showing no sign of retreating, electronic systems deployed in automotive applications are subject to more stringent Electromagnetic Immunity compliance constraints than ever before, to ensure the proximity of nearby electronic systems will not affect their operation. The EMI compliance testing of an analog camera link requires video quality to be monitored and assessed to validate such compliance, which up to now, has been a manual task. Due to the nature of human interpretation, this is open to inconsistency. Here, we propose a solution
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Reports on the topic "Trained immunity"

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Palmer, Guy, Varda Shkap, Wendy Brown, and Thea Molad. Control of bovine anaplasmosis: cytokine enhancement of vaccine efficacy. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695879.bard.

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Anaplasmosis an arthropod-born disease of cattle caused by the rickettsia Anaplasma marginale and is an impediment to efficient production of healthy livestock in both Israel and the United States. Currently the only effective vaccines are derived from the blood of infected cattle. The risk of widespread transmission of both known and newly emergent pathogens has prevented licensure of live blood-based vaccines in the U.S. and is a major concern for their continued use in Israel. Consequently development of a safe, effective vaccine is a high priority. In this collaborative project we focused
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