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Journal articles on the topic 'Tranexam'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Tikhilov, R. M., I. I. Shubnyakov, M. I. Mokhanna, et al. "Efficacy of Tranexamic Acid Application for Blood Loss Reduction in Total Hip Arthroplasty." N.N. Priorov Journal of Traumatology and Orthopedics 17, no. 1 (2010): 29–34. http://dx.doi.org/10.17816/vto201017129-34.

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Prospective study of tranexamic acid use results (native preparation Tranexam) in primary total hip arthroplasty was performed during the period from March to October 2009. The study involved 159 patients (55 men, 104 women) with various hip joint pathology (79 patients - main group, 80 patients - control group). Mean age of patients made up 55.7 years (17 - 80 years). In patients from the main group 15 mg/kg Tranexam was injected just prior to operation with reinjection of the same dose in 6 hours. In control group etamsylate (750 mg 30 minutes prior to incision with reintroduction in 4 - 6 h

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Goloshchapov, Evgenii T., and Georgiy B. Lukichev. "Peculiarities of hemostasis in transurethral resection of prostatic gland using fybrinolysis inhibitor." Urology reports (St. - Petersburg) 1, no. 1 (2021): 27–29. http://dx.doi.org/10.17816/uroved57654.

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Tissue plasminogen activator being the most important component part of fybrinolysis is producing and accumulating in the prostatic gland. In surgical treatment of prostate an increased bleeding often occurs during the surgical operations on the prostate during as well as in post-operative period. General and local fybrino- lysis increase is in case among the reasons of haemor-ragy as a result of mechanical action on prostatic gland tissue in the process of an operation. It is suggested the use of Tranexam a tranexamic acid drug to neutralize an increasing fybrinolysis. In 83 patients with ben

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Pyrohova, V. I., and O. O. Oshurkevich. "Antifibrinolytic therapy in the clinic for miscarriage – aspects of medical tactics." HEALTH OF WOMAN, no. 4(120) (May 30, 2017): 78–82. http://dx.doi.org/10.15574/hw.2017.120.78.

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The objective: to evaluate the efficacy of tranexamic acid (Tranexam drug) accompanied by pregnancy with a partial detachment of a normally located placenta in the second trimester of pregnancy in women with a history of obstetrical gynecological anamnesis. Patients and methods. Under observation were 75 patients with complicated retrochorial hematoma at first trimester of pregnancy, re-hospitalized at the time of 18–21 weeks with signs of premature placental abruption. The blind method of the patient was randomized into two groups (baseline and comparison), which differed in the type of haemo

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Vlasov, S. V., and A. A. Pronskikh. "Use of Tranexamic Acid at Knee Joint Arthroplasty." N.N. Priorov Journal of Traumatology and Orthopedics 19, no. 3 (2012): 64–69. http://dx.doi.org/10.17816/vto20120364-69.

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Results of comparative study of the efficacy and safety of intraoperative application of tranexam versus autoplasma in patients with planned surgical blood loss and high risk of venous thrombosis development has been presented. One hundred seven patients admitted for total knee replacement were divided into 2 groups. In the main group (55 patients) intraoperative intravenous infusion of 10 mg/kg tranexam were used. In the control group (52 patients) intraoperative hemodilution with autoplasma was performed. Hemostasis indices (APTT, INR, SFMC, D- dimer) and lysis index were studied before surg

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Goloshchapov, Yevgeniy Tikhonovich, Georgiy Borisovich Lukichev, Yevgeniy Stanislavovich Nevirovich, Igor Valentinovich Kuzmin, and Yuriy Anatolyevich Ignashov. "Evaluating the effectiveness of Tranexam by transurethral resection of the prostate in patients with BPH." Urologicheskie vedomosti 2, no. 4 (2012): 16. http://dx.doi.org/10.17816/uroved2416-19.

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Lomonosov, A. L., A. A. Golubev, M. A. Kukanova, A. A. Khomenchuk, A. H. Khushakov, and G. D. Lomonosov. "Diagnosis and treatment of external hemorrhoids on an outpatient basis." Clinical Medicine (Russian Journal) 101, no. 6 (2023): 301–7. http://dx.doi.org/10.30629/0023-2149-2023-101-6-301-307.

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There are many variants of acute external hemorrhoids (AEH), with varying degrees of its development. The purpose of the study is to study the features of diagnosis and treatment of outpatient patients with AEH in the form of ovoid (AEH–FO). Material and methods. A solid sample, a retrospective sequential study of the data of 97 outpatient patients with AEH–FO. AEH–FO of the first degree (AEH–FO 1) was detected in 57,7% of patients, the node was more often elastic, blue in color, AEH–FO of the second degree (AEH–FO 2) in 42,3% of patients, wound necrosis on the node, the discharge of blood fro

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E.N.Imamov and E.R.Bekmirzaev. "CAUSES AND PREVENTION OF EARLY POST-PREGNANT BLEEDING." EURASIAN JOURNAL OF MEDICAL AND NATURAL SCIENCES 2, no. 4 (2022): 60–63. https://doi.org/10.5281/zenodo.6506666.

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Obstetric hemorrhages are among the top three causes of maternal death. At the same time, early postpartum hemorrhage occurring in the first 24 hours after birth accounts for a quarter of all maternal deaths worldwide. Changes in the blood coagulation system during pregnancy consist in a constant decrease in fibrinolytic activity and an increase in blood coagulation. These changes have a pronounced adaptive character and are aimed primarily at reducing the volume of physiological blood loss during childbirth. The article discusses the most common causes and risk factors for postpartum hemorrha

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Arzhakova, Nadezhda Ivanovna, A. I. Bernakevich, E. V. Shushpanova, N. I. Arzhakova, A. I. Bernakevich, and E. V. Shushpanova. "Blood Saving Effect of Tranexame at Hip Joint Replacement." N.N. Priorov Journal of Traumatology and Orthopedics 16, no. 4 (2009): 13–18. http://dx.doi.org/10.17816/vto200916413-18.

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Study of the efficacy (by the results of blood saving action assessment) and application safety of tranexamic acid (home antifibrinolytic drug Tranexame) at hip arthroplasty was performed. Perioperative blood loss (intraoperative + postoperative blood loss by drainages during 24 hours), need in hemotransfusion, laboratory indices (hemoglobin, hematocrit, coagulograms) before and after operation were analyzed in 43 patients. Twenty patients received 4 g of Tranexame daily (main group) and 23 patients did not receive antifibrinolytic drugs. In the main group reliable decrease in blood loss as co

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Fedorova, T. A., R. G. Shmakov, O. V. Rogachevskiy, et al. "Patient’s blood management in obstetric practice with placenta accrete." Medical Council, no. 7 (April 5, 2019): 134–41. http://dx.doi.org/10.21518/2079-701x-2019-7-134-141.

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Placenta accreta is one of the most severe anomalies of attachment, due to the high risk of massive bleeding. At present, the paradigm of organ-preserving delivery is laid. The implementation of this tactic is possible in the context of the introduction into the obstetric practice of patient blood management (PBM).Objective:to evaluate the effectiveness of blood preservation methods in the management and delivery of pregnant women with placenta placenta accrete.Materials and methods:The study group consisted of 59 pregnant women with placenta accreta in age from 20 to 40 years old (32,43 ± 5,0

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Masood, Javeria, Zartaj Hayat, Nadia Ahmed, Robina Jabeen, Nazish Shifa, and Faiza Masud. "Comparison of Estimated Blood Loss between Tranexamic Acid and Control in Women Undergoing Elective Cesarean Section." Pakistan Journal of Medical and Health Sciences 17, no. 4 (2023): 288–90. http://dx.doi.org/10.53350/pjmhs2023174288.

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Background: Tranexamic acid is being utilized related to uterotonic agents to treat hemorrhage post-delivery. Evidence suggests that tranexamic acid may reduce bleeding and resultant chances of postpartum hemorrhage. However, limited data is available on the prophylactic utilization of tranexamic acid in local women undergoing elective lower segment cesarean section. This study aimed to compare reduction in mean blood loss between control and tranexamic acid group during and after elective lower segment cesarean section. Methodology: This randomized controlled trial was done in a period of 6 m

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Clay, T. Bradly, A. Sayo Lawal, Thomas W. Wright, et al. "Tranexamic acid use is associated with lower transfusion rates in shoulder arthroplasty patients with preoperative anaemia." Shoulder & Elbow 12, no. 1_suppl (2019): 61–69. http://dx.doi.org/10.1177/1758573219841058.

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Background We evaluate tranexamic acid use in high-risk shoulder arthroplasty patients, hypothesizing that tranexamic acid will decrease transfusion rates in patients with low preoperative haematocrit. Methods A retrospective review of shoulder arthroplasty patients with preoperative anaemia compared those treated with and without perioperative tranexamic acid. Inclusion criterion was any shoulder arthroplasty with a preoperative haematocrit (Hct) <38%. Tranexamic acid was given generally as 1 g intravenously before incision and 1 g during wound closure; topical tranexamic acid was used in

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Essien UE, Inyang UC, Itakpe SE, Lawal WO, Dim EM, and Usendiah IB. "Efficacy of oral Tranexamic Acid in reducing blood loss during primary total hip arthroplasty: A comparative study." Ibom Medical Journal 16, no. 2 (2023): 148–53. http://dx.doi.org/10.61386/imj.v16i2.311.

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Background: Perioperative blood loss is a major concern for patients undergoing total hip arthroplasty. Intravenous Tranexamic acid is commonly used to reduce blood loss and need for blood transfusion following total hip replacement. Recent studies have shown the efficacy of oral tranexamic acid in reducing perioperative blood loss in total hip replacement. Method: A total of 69 patients undergoing primary total hip replacement in National Orthopaedic Hospital, Igbobi, Lagos, were recruited. Patients were randomized to receive 2gram oral tranexamic acid 2hours before incision or 1-gram i

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Jinliang, Wang, and Wei Xuan. "Effect of tranexamic acid on the timing of drainage tube removal in total knee arthroplasty." Orthopaedic Journal of Sports Medicine 8, no. 9_suppl7 (2020): 2325967120S0052. http://dx.doi.org/10.1177/2325967120s00525.

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Introduction: To investigate the effect of tranexamic acid on the removal time of drainage tube in the first unilateral total knee arthroplasty. Hypotheses: The timing of removing the drinage system can be changed when using TXA. Methods: From June 2017 to December 2018, 182 patients (42 males and 140 females) who planned to undergo primary unilateral total knee replacement were included.Age (68.1±7.1) years (60-76 years).According to the random number table method, it was divided into four groups: 45 cases of Tranexamic acid group 1 (TXA1), 46 cases of Tranexamic acid group 2 (TXA2), 46 cases

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Moran, N. F., D. G. Bishop, S. Fawcus, et al. "Tranexamic Acid at Cesarean Delivery: Drug-error Deaths." Obstetric Anesthesia Digest 43, no. 4 (2023): 166–67. http://dx.doi.org/10.1097/01.aoa.0000990292.62353.a6.

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(Am J Obstet Gynecol. 2023;228:1–4) Tranexamic acid plays an important role in reducing bleeding experienced during postpartum hemorrhage. It is recommended by the World Health Organization that tranexamic acid is administered intravenously, over 10 minutes, within 3 hours of delivery to treat postpartum hemorrhage. However, tranexamic acid, although helpful in cases of postpartum hemorrhage, has caused other problems to arise. It has been found that tranexamic acid is toxic when administered intrathecally (IT). Tranexamic acid has components that are known to lead to neuronal excitation when

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Miyashita, Tetsuya, Takahiko Kamibayashi, Yoshihiko Ohnishi, Junjiro Kobayashi, and Masakazu Kuro. "Preservation of collagen-induced whole blood platelet aggregation by tranexamic acid therapy in primary cardiac valve surgery." Perfusion 15, no. 6 (2000): 507–13. http://dx.doi.org/10.1177/026765910001500606.

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Haemostatic disorder is one of the most common complications following cardiac surgery with cardiopulmonary bypass (CPB). Tranexamic acid reduces blood loss and allogeneic blood transfusion requirement in cardiac surgery. It had been thought that tranexamic acid inhibited fibrinolysis alone following CPB. In the present study, the haemostatic effects of tranexamic acid (20 mg/kg body weight bolus after induction of anaesthesia followed by continuous infusion at 2 mg/kg/h), including fibrinolysis and platelet function, were investigated in 22 patients (tranexamic acid group n = 12; control grou

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Townsley, M. I., S. A. Barman, and A. E. Taylor. "Pulmonary embolism: emboli and fibrinolysis inhibition in isolated canine lungs." American Journal of Physiology-Heart and Circulatory Physiology 258, no. 3 (1990): H754—H758. http://dx.doi.org/10.1152/ajpheart.1990.258.3.h754.

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The effect of fibrinolysis inhibition with tranexamic acid on pulmonary microvascular permeability during glass bead embolization was investigated in the isolated lung. Lung lobes from nonheparinized dogs were treated in vivo with the equivalent of 0.6 g/kg 100 microns glass bead emboli alone, emboli after tranexamic acid, tranexamic acid alone, or the bead vehicle alone. After 40-50 min, the lobes were isolated for ex vivo perfusion with heparinized autologous blood. There were no changes in any parameter over the 120-min perfusion period. Blood flow at 120 min was decreased after both emboli

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Zhang, Feiyang, Wenjun Dong, Fengyan Wang, et al. "The Topical Tranexamic Acid Have Potential Hazard of Promoting Biofilm Formation of Staphylococcus aureus in Microenvironment of the Prosthetic Joint." BioMed Research International 2021 (March 11, 2021): 1–8. http://dx.doi.org/10.1155/2021/5748069.

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Background. Perioperative topical tranexamic acid as antifibrinolytic agent is often used for total joint replacement to reduce bleeding currently. Staphylococcus aureus was the most common isolates from perioperative infection of prosthetic joint. The influence of topical application with tranexamic acid on the incidence of acute prosthetic joint infection of Staphylococcus aureus has not been clarified. Methods. Mouse model of Staphylococcus aureus knee prosthesis infection was constructed. Tranexamic acid was intra-articular injected during the perioperative period. CFU counting from tissue

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Luo, Hua, Chaojun Shen, Tongyou Qu, Lin Chen, Yue Sun, and Yu Ren. "Tranexamic acid-induced focal convulsions after spinal surgery: a rare case report and literature review on side effects of accidental spinal administration of tranexamic acid." EFORT Open Reviews 8, no. 6 (2023): 482–88. http://dx.doi.org/10.1530/eor-23-0016.

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Convulsions are a neurological illness that has complexity. In clinical treatment, drug-induced convulsions appear from time to time. Drug-induced convulsions often begin as isolated acute seizures but may progress to persistent seizures. In orthopedics, topical administration of tranexamic acid is commonly used in conjunction with intravenous drip to achieve hemostasis during artificial joint replacement surgery. However, side effects induced by tranexamic acid accidental spinal administration should be taken seriously. We report a case of a middle-aged male treated with tranexamic acid local

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Minaei, Reza, Seyed Morteza Kazemi, Seyyed Mehdi Hoseini, Alireza Mirahmadi, Pooya Hosseini-Monfared, and Maryam Salimi. "Combined intravenous and intraarticular tranexamic acid compared with intraarticular use alone in total knee arthroplasty: A randomized controlled trial." Indian Journal of Orthopaedics Surgery 9, no. 3 (2023): 162–67. http://dx.doi.org/10.18231/j.ijos.2023.032.

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: Total knee arthroplasty is associated with high rates of blood loss during and after the surgery. Tranexamic acid is an antifibrinolytic agent that effectively reduces total blood loss in total knee arthroplasty and minimizes the need for blood transfusion and transfusion-related complications. However, the most efficacious route of tranexamic acid administration has not been established. Therefore, in this study, we aimed to compare combined intravenous and intraarticular tranexamic acid with intraarticular use alone in patients undergoing total knee arthroplasty.In this randomized, double-

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Elfadli, Mustafa M. "Comparative Study of Reducing Blood Loss in Total Knee Replacement with and without the Use of Tranexamic Acid, Tourniquet, and Drainage." Journal of Medical Science and clinical Research 12, no. 07 (2024): 01–04. http://dx.doi.org/10.18535/jmscr/v12i07.01.

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Background: Patients who undergo total knee arthroplasty (TKA) may develop large blood loss. The intraoperative and postoperative blood loss after TKA ranges from 1500 to 1900 cc. TKA is often carried out using a tourniquet and drains to collect the shedded blood loss. However, tranexamic acid is found to decrease blood loss. Tranexamic acid is a fibrinolysis inhibitor that blocks the plasminogen, and it has been reported before that it reduces blood loss in patients undergoing TKA. However, few reports describe the effects of tranexamic acid on blood loss in patients who underwent TKA. Object

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Liu, Fei, Dong Xu, Kefeng Zhang, and Jian Zhang. "Effects of tranexamic acid on coagulation indexes of patients undergoing heart valve replacement surgery under cardiopulmonary bypass." International Journal of Immunopathology and Pharmacology 29, no. 4 (2016): 753–58. http://dx.doi.org/10.1177/0394632016671142.

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This study aims to explore the effects of tranexamic acid on the coagulation indexes of patients undergoing heart valve replacement surgery under the condition of cardiopulmonary bypass (CPB). One hundred patients who conformed to the inclusive criteria were selected and divided into a tranexamic acid group and a non-tranexamic acid group. They all underwent heart valve replacement surgery under CPB. Patients in the tranexamic acid group were intravenously injected with 1 g of tranexamic acid (100 mL) at the time point after anesthesia induction and before skin incision and at the time point a

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Moscote-Salazar, Luis Rafael, Amit Agrawal, Andres M. Rubiano, et al. "An international based survey on perioperative use of tranexamic acid in neurotrauma." Romanian Neurosurgery 30, no. 2 (2016): 248–51. http://dx.doi.org/10.1515/romneu-2016-0038.

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Abstract Background: Tranexamic acid is used to reduce bleeding, easy to use, affordable and relatively safe. There are few studies on the use of tranexamic acid in trauma and especially in neurosurgery. There is no published study on the trend the use of tranexamic acid in neurotrauma surgery among international doctors. The aim of this study was to evaluate the current practice for use of tranexamic acid during neurotrauma surgery. Materials and Methods: A 11-question electronic survey was sent to 25 practicing physicians worldwide. Basic demographic information and estimated rates of use of

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Ravi, Gopala K., Nidhi Panda, Jasmina Ahluwalia, Rajeev Chauhan, Navneet Singla, and Shalvi Mahajan. "Effect of tranexamic acid on blood loss, coagulation profile, and quality of surgical field in intracranial meningioma resection: A prospective randomized, double-blind, placebo-controlled study." Surgical Neurology International 12 (June 7, 2021): 272. http://dx.doi.org/10.25259/sni_296_2021.

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Background: Resection of intracranial meningioma has been associated with significant blood loss. Providing a clear surgical field and maintaining hemodynamic stability are the major goals of anesthesia during meningioma surgery. Tranexamic acid has been used to reduce blood loss in various neurosurgical settings with limited evidence in literature. A randomized, double-blind, and placebo-controlled trial was conducted to evaluate the efficacy of tranexamic acid on blood loss, coagulation profile, and quality of surgical field during resection of intracranial meningioma. Methods: Thirty patien

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Utomo, Dwikora Novembri, Teddy Heri Wardhana, Ahmad Hannan Amrullah, and Hamzah Hamzah. "THE EFFECT OF TRANEXAMIC ACID INJECTION ON HEMOGLOBIN LEVEL, ALBUMIN LEVEL, AND PAIN ON PATIENT RECEIVING TOTAL KNEE REPLACEMENT." (JOINTS) Journal Orthopaedi and Traumatology Surabaya 8, no. 1 (2019): 1. http://dx.doi.org/10.20473/joints.v8i1.2019.1-11.

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Background: The high number of knee osteoarthritis cases could lead arthroplasty more frequent. Total Knee Replacement (TKR) surgery procedure is at risk of massive bleeding. Bleeding can affect albumin levels and the onset of intra-compartment pressure on the nerves. The use of tranexamic acid could be done to reduce bleeding.Objective: Proving the effect of intravenous tranexamic acid administration on patients who will undergo TKR surgery.Methods: The experiment was conducted experimentally using primary laboratory data obtained before and after surgery in patient which will be performed TK

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Hapsari, Rania Adeastri, and Tendy Novara. "Tranexamic acid-induced seizures in postpartum patients." International journal of health & medical sciences 7, no. 3 (2024): 53–58. http://dx.doi.org/10.21744/ijhms.v7n3.2288.

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Introduction: Tranexamic acid has found extensive application in obstetrics to prevent and treat postpartum hemorrhage (PPH). This case report investigated an infrequent incidence in which seizures were caused by the administration of tranexamic acid. Even though tranexamic acid is generally regarded as safe, it has been associated with the infrequent yet serious side effects of tranexamic acid-induced seizures. This case report was aimed at investigating the infrequent incidence of tranexamic acid-induced seizures in postpartum patients. Case: It was reported that a woman who was 40 weeks pre

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Nishat, Mufassar, Sohail Iqbal, Armaghan Ahmed, Shoaib Younas, Liaqat Ali Deokah, and Zakariya Rashid. "Clinical study of Evaluation of the Effect of Tranexamic Acid in Primary Cleft Palate Surgery in Children." Pakistan Journal of Medical and Health Sciences 15, no. 10 (2021): 2708–10. http://dx.doi.org/10.53350/pjmhs2115102708.

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Aim : To evaluate tranexamic acid effect on quality of surgery. Design: Double-blind study, Prospective and randomized Place & time of study: June 2020 to may 2021Allama iqbal memorial trust hospital Gujranwala. Methods: Two groups of candidates were made. The saline was administered to the control group whereas tranexamic acid was administered as 0.01g/kg in a bolus form, before surgical incision to tranexamic acid group. On a 10-point scale, grading of surgical field, primary hemorrhage and satisfaction of surgeon Results: As far as operating surgeon satisfaction is concerned, noteworthy

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Bogner, Elodie, Elodie Ferrero, Joelle Marin, and Stanislas Bataille. "Peritoneal dialysis catheter dysfunction due to fibrin clots following treatment with tranexamic acid: a clinical case." Bulletin de la Dialyse à Domicile 4, no. 2 (2021): 121–28. http://dx.doi.org/10.25796/bdd.v4i2.61393.

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Chronic kidney disease patients experience not only more frequent arterial and venous thrombosis but also hemorrhagic episodes. Tranexamic acid is an anti-fibrinolytic molecule that inhibits plasmin activation. It is used in hemorrhage cases (post-traumatic, gynecologic, or gastrointestinal bleeding). We report on an original case of tranexamic acid (Exacyl®) use in a peritoneal dialysis patient for gastrointestinal bleeding of unknown origin. The use of tranexamic acid led to the Tenckhoff catheter dysfunction because of fibrin clots in the dialysate. The emergence of fibrin clots

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Vogt, Ashtyn Z., Pouriska B. Kivanany, Matthew A. De Niear, Ivan M. Vrcek, and Natalie A. Homer. "The Effect of Intravenous Tranexamic Acid on Postoperative Ecchymoses after Upper Blepharoplasty." Plastic and Reconstructive Surgery - Global Open 12, no. 8 (2024): e6089. http://dx.doi.org/10.1097/gox.0000000000006089.

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Background: Tranexamic acid has been increasingly used in facial plastic surgery to improve perioperative hemostasis. While subcutaneous tranexamic acid has been found to not significantly decrease postoperative ecchymoses following upper blepharoplasty, systemic administration has not previously been studied. Methods: A total of 325 patients undergoing upper blepharoplasty were randomly assigned to either receive intravenous tranexamic acid or serve as a control. Patients in the experimental group were administered 1 g of tranexamic acid intravenously 10 minutes before surgical incision. A si

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Horrow, Jan C., Daniel F. Van Riper, Michael D. Strong, Karl E. Grunewald, and Jonathan L. Parmet. "The Dose-Response Relationship of Tranexamic Acid." Anesthesiology 82, no. 2 (1995): 383–92. http://dx.doi.org/10.1097/00000542-199502000-00009.

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Background Prophylactic administration of the antifibrinolytic drug tranexamic acid decreases bleeding and transfusions after cardiac operations. However, the best dose of tranexamic acid for this purpose remains unknown. This study explored the dose-response relationship of tranexamic acid for hemostatic efficacy after cardiac operation. Methods In prospective, randomized, double-blinded fashion, 148 patients undergoing cardiac operation with extracorporeal circulation were divided into six groups: a placebo group and five groups receiving tranexamic acid in loading doses before incision (ran

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Prakash, Jatin, Jong-Keun Seon, Yong Jin Park, Cheng Jin, and Eun-Kyoo Song. "A randomized control trial to evaluate the effectiveness of intravenous, intra-articular and topical wash regimes of tranexamic acid in primary total knee arthroplasty." Journal of Orthopaedic Surgery 25, no. 1 (2017): 230949901769352. http://dx.doi.org/10.1177/2309499017693529.

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Background: The efficacy of tranexamic acid to decrease post-operative blood loss and blood transfusion is well established in literature. However, the ideal mode of administration is debatable. Limited literature has compared all the available modes of administration including intravenous (IV), topical irrigation and retrograde through drain. We hypothesized that no difference would be present in either form of administration of tranexamic acid. Methods: Fifty patients in four groups were enrolled for study. Group 1 received drug intravenously, group 2 had topical washing with drug before clo

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Aziz, Bara’a Mahir, Islam Al-Talibi, Shalan Mufleh Darak, Ali Abdulmuttalib Mohammed, and Haitham Alnori. "Tranexamic acid versus adrenaline-soaked pledgets for the reduction of intraoperative bleeding in functional endoscopic sinus surgery." Polski Merkuriusz Lekarski 52, no. 1 (2024): 36–41. http://dx.doi.org/10.36740/merkur202401106.

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Aim: To examine the impact of locally applied tranexamic acid and adrenaline, separately and in combination, on intraoperative blood loss and surgical field quality during functional endoscopic sinus surgery. Materials and Methods: The study involved 40 patients with chronic rhinosinusitis. They were divided into two groups. Group I received adrenaline alone in one side and a mixture of adrenaline and tranexamic acid in the other side. Group II received adrenaline alone in one side and tranexamic acid in the otherside. Parameters like surgery time, blood loss, and surgical field quality were s

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Ligon, Jona Minette E., and Natividad A. Almazan. "The Effectiveness of Intravenous Tranexamic Acid on Blood Loss and Surgical Time During Endoscopic Sinus Surgery: A Systematic Review." Philippine Journal of Otolaryngology-Head and Neck Surgery 31, no. 2 (2018): 8–12. http://dx.doi.org/10.32412/pjohns.v31i2.221.

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Objective: To review the effectiveness of intravenous tranexamic acid in reduction of blood loss, surgical time and field visualization among patients who underwent endoscopic sinus surgery (ESS) for chronic rhinosinusitis (CRS).  Methods: Data Sources: MEDLINE (PubMed), EMBASE, ScienceDirect, HERDIN, and the Cochrane Library. Eligibility Criteria: Randomized controlled trials (RCT) between 2005-2014 that evaluated the effects of tranexamic acid or placebo in patients undergoing ESS for CRS. Appraisal and Synthesis Methods: Articles were selected by 2 independent review

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Ashraf, Muhammad Asif, Ishfaq Ahmed, Sanaullah Bhatti, Deepak Rai, and Rana Farrukh Tasleem. "Compare Mean Blood Loss in Patients Undergoing Tonsillectomy with and without Tranexamic Acid." Pakistan Journal of Medical and Health Sciences 16, no. 7 (2022): 799–801. http://dx.doi.org/10.53350/pjmhs22167799.

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Introduction: Tonsillectomy is one of the most common surgeries in ENT department and bleeding is one of the most serious complications related to tonsillectomy. Tranexamic acid is a plasminogen inhibitor which has been successfully used to control bleeding in a variety of surgeries. Objective: The objective of this study is to compare mean blood loss in patients undergoing tonsillectomy with and without Tranexamic acid. Study Design: Randomized controlled trail Setting: This study was carried out at the Department of ENT Jinnah Hospital Lahore Sample Technique: Non-probability, consecutive sa

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Lecker, Irene, Dian-Shi Wang, Kirusanthy Kaneshwaran, C. David Mazer, and Beverley A. Orser. "High Concentrations of Tranexamic Acid Inhibit Ionotropic Glutamate Receptors." Anesthesiology 127, no. 1 (2017): 89–97. http://dx.doi.org/10.1097/aln.0000000000001665.

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Abstract Background The antifibrinolytic drug tranexamic acid is structurally similar to the amino acid glycine and may cause seizures and myoclonus by acting as a competitive antagonist of glycine receptors. Glycine is an obligatory co-agonist of the N-methyl-d-aspartate (NMDA) subtype of glutamate receptors. Thus, it is plausible that tranexamic acid inhibits NMDA receptors by acting as a competitive antagonist at the glycine binding site. The aim of this study was to determine whether tranexamic acid inhibits NMDA receptors, as well as α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid an

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Ghaly Tawadros, Safaa Ishak, Marwa A. Khairy, Eman A. Mohammed, and Mohamed M. Kamal. "Single intravenous bolus vs. continuous infusion of tranexamic acid to reduce blood loss in transurethral resection of prostate: a prospective randomized double-blind study." Anaesthesia, Pain & Intensive Care 29, no. 2 (2025): 210–16. https://doi.org/10.35975/apic.v29i2.2705.

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Background and objective: Intraoperative a single bolus of tranexamic acid may be inadequate to prevent bleeding in the early postoperative period. We compared the effect of two dose regimens of tranexamic acid in reducing perioperative blood loss and the amount of allogeneic blood transfusion in transurethral resection of prostate (TURP). Methods: A total of 50 patients electively posted for TURP, were randomly assigned to receive either a single bolus dose of tranexamic acid 10 mg/kg (Group A), or a bolus of tranexamic acid 10 mg/kg followed by an infusion of tranexamic acid @1 mg/kg/h till

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Law, Zhe Kang, Atte Meretoja, Stefan T. Engelter, et al. "Treatment of intracerebral haemorrhage with tranexamic acid – A review of current evidence and ongoing trials." European Stroke Journal 2, no. 1 (2016): 13–22. http://dx.doi.org/10.1177/2396987316676610.

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Purpose Haematoma expansion is a devastating complication of intracerebral haemorrhage (ICH) with no established treatment. Tranexamic acid had been an effective haemostatic agent in reducing post-operative and traumatic bleeding. We review current evidence examining the efficacy of tranexamic acid in improving clinical outcome after ICH. Method We searched MEDLINE, EMBASE, CENTRAL and clinical trial registers for studies using search strategies incorporating the terms ‘intracerebral haemorrhage’, ‘tranexamic acid’ and ‘antifibrinolytic’. Authors of ongoing clinical trials were contacted for f

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Xiaofei, Luo, Wie Xuan, and Wang Jinliang. "Effect of tranexamic acid on ischemia － reperfusion injury caused by application of tourniquet in the surgery of total knee arthroplasty." Orthopaedic Journal of Sports Medicine 8, no. 9_suppl7 (2020): 2325967120S0053. http://dx.doi.org/10.1177/2325967120s00532.

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Introduction: Tranexamic acid can effectively reduce the amount of perioperative bleeding in artificial joint replacement surgery, but some reports showing that the application of tranexamic acid in cardiac surgery can reduce the ischemia-reperfusion injury. Does tranexamic acid reduce the tourniquet Ischemia-reperfusion injury in the surgery of toutal knee arthroplasty is unclear. Hypotheses: To observe the effect of intravenous combined local tranexamic acid on the expression of IL-6 and TNF-α in peripheral blood and drainage fluid of patients with tourniquet in primary total knee arthroplas

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Clinkard, David, and David Barbic. "Tranexamic Acid for Epistaxis–A Promising Treatment That Deserves Further Study." CJEM 18, no. 1 (2015): 72–73. http://dx.doi.org/10.1017/cem.2015.55.

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Clinical QuestionDoes the application of topical tranexamic acid reduce bleeding as compared to anterior packing?Article ChosenZahed R, Moharamzadeh P, Alizadeharasi S, et al. A new and rapid method for epistaxis treatment using injectable form of tranexamic acid topically: a randomized controlled trial. Am J Emerg Med 2013;31(9):1389-92.ObjectivesTo determine if topically applied tranexamic acid reduces bleeding time in epistaxis.

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Liu, Jingyi, Ximing Nie, Hongqiu Gu, et al. "Tranexamic acid for acute intracerebral haemorrhage growth based on imaging assessment (TRAIGE): a multicentre, randomised, placebo-controlled trial." Stroke and Vascular Neurology 6, no. 2 (2021): 160–69. http://dx.doi.org/10.1136/svn-2021-000942.

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BackgroundStudies show tranexamic acid can reduce the risk of death and early neurological deterioration after intracranial haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma expansion and improves outcome in intracerebral haemorrhage patients susceptible to haemorrhage expansion.MethodsWe did a prospective, double-blind, randomised, placebo-controlled trial at 10 stroke centres in China. Acute supratentorial intracerebral haemorrhage patients were eligible if they had indication of haemorrhage expansion on admission imaging (eg, spot sign, black hole sign or blend sign)

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Bao, Xianguo, Haitao Lu, Zengxin Gao, et al. "Meta-Analysis of the Efficacy and Safety of Tranexamic Acid in Spinal Surgery." Computational and Mathematical Methods in Medicine 2022 (July 27, 2022): 1–10. http://dx.doi.org/10.1155/2022/9406497.

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Objective. The safety and effectiveness of topical tranexamic acid in spinal surgery has not yet been reached, and further research is needed to confirm it. This study is aimed at detecting the effectiveness and safety on the tranexamic acid in spinal surgery. Methods. The Cochrane Library, PubMed, Embase, CNKI, and other databases were searched. The search time was from 2016 to 2019. All randomized controlled trials comparing the topical tranexamic acid group and the control group were collected. The experimental group used topical application. Tranexamic acid was used to treat bleeding after

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Azkiyah, Siti Zamilatul, Sudibyo Supardi, and Retnosari Andrajati. "THE RISKS OF USING TRANEXAMIC ACID AND VITAMIN K FOR DECREASING PROTHROMBIN TIME AND ACTIVATED PARTIAL THROMBOPLASTIN TIME VALUES IN INTRACRANIAL HEMORRHAGIC PATIENTS AT RUMAH SAKIT UMUM PUSAT FATMAWATI JAKARTA." Asian Journal of Pharmaceutical and Clinical Research 10, no. 17 (2017): 139. http://dx.doi.org/10.22159/ajpcr.2017.v10s5.23117.

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Objective: Intracranial hemorrhaging is a life-threatening condition that requires intensive treatment. Such hemorrhaging can happen spontaneously and may be caused by vascular malformations, trauma, or the administration of anticoagulant medications. The purpose of this study was to evaluate the risks of using tranexamic acid and Vitamin K for decreasing prothrombin time (PT) and activated partial thromboplastin time (aPTT) values in intracranial hemorrhagic patients.Methods: This study used a retrospective cohort design, and data were taken from patients’ medical records at the medical recor

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Akinlua, Gbenga Damilola, Jacob Olumuyiwa Awoleke, Idowu Pius Ade-Ojo, Samson Gbenga Oluwayomi, Omoyemi Adeoti Akinlua, and Margaret Adefiola Oluwayemi. "Effect of Intravenous Tranxenamic Acid On Incidence of Postpartum Haemorrhage Among Parturients in Ekiti State." nternational Journal of Public Health Pharmacy and Pharmacology 8, no. 4 (2023): 26–34. http://dx.doi.org/10.37745/ijphpp.15/vol8n42634.

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Post-partum haemorrhage (PPH) contributes to approximately 25% of maternal death globally. Tranexamic acid (TXA) has been confirmed to be effective in reducing post-partum blood loss, thereby preventing PPH and its possible sequelae. This clinical controlled trial compared the efficacy of a single dose of 0.5g of intravenous TXA to a single dose of 1g of intravenous TXA in prevention of primary PPH among high-risk parturient women in a teaching hospital. A total of 308 women served as the study sample; 154 women were randomly selected to be administered with 0.5g of tranexamic acid (study grou

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Sethna, Navil F., David Zurakowski, Robert M. Brustowicz, Julianne Bacsik, Lorna J. Sullivan, and Frederic Shapiro. "Tranexamic Acid Reduces Intraoperative Blood Loss in Pediatric Patients Undergoing Scoliosis Surgery." Anesthesiology 102, no. 4 (2005): 727–32. http://dx.doi.org/10.1097/00000542-200504000-00006.

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Background Excessive bleeding often occurs during pediatric scoliosis surgery and is attributed to numerous factors, including accelerated fibrinolysis. The authors hypothesized that administration of tranexamic acid would reduce bleeding and transfusion requirements during scoliosis surgery. Methods Forty-four patients scheduled to undergo elective spinal fusion were randomly assigned to receive either 100 mg/kg tranexamic acid before incision followed by an infusion of 10 mg . kg . h during surgery (tranexamic acid group) or 0.9% saline (placebo group). General anesthesia was administered ac

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Prathap, Mr A., Roja M K, Samyuktha D V, Saranya R, Shruthi D, and Priyadarshini P. "Tranexamic Acid and its Role in Total Knee Replacement." International Journal for Research in Applied Science and Engineering Technology 11, no. 9 (2023): 518–25. http://dx.doi.org/10.22214/ijraset.2023.55659.

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Abstract: Tranexamic acid is a synthetic lysine derivative that inhibits the lysine binding sites on plasminogen molecules in order to have an antifibrinolytic action. In patients with upper gastrointestinal bleeding, tranexamic acid was related to mortality decreases of 5 to 54% when compared to placebo. A 40% reduction was found by meta-analysis. Tranexamic acid therapy reduced mean menstrual blood loss in menstruating women with menorrhagia by 34 to 57.9% in comparison to placebo or control; the medication has also been successfully used to treat placental bleeding, postpartum hemorrhage, a

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Dogbanya, Gabriel. "Effect of Tranexamic Acid on Primary Postpartum Haemorrhage in at Risk Women at Abuth, Zaria: A Randomized Controlled Study." Journal of Medical Science And clinical Research 11, no. 08 (2023): 01–09. http://dx.doi.org/10.18535/jmscr/v11i8.01.

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Background: Postpartum haemorrhage is an obstetric nightmare. Although it may occur in women with no identified risk, women with certain risk profiles are at increased risk PPH. Tranexamic acid has been shown to be effective in low risk women. Aim: To compare the effectiveness of Tranexamic acid to placebo in preventing PPH in at-risk women following vaginal delivery. Research Methods: The study was a randomized controlled trial at ABUTH, Zaria, in which 334 women identified as being at risk for PPH, were sequentially randomized into Tranexamic and placebo groups of 167 each. The Tranexamic ac

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Barbilian, Raluca Costina, Victor Cauni, Bogdan Mihai, Ioana Buraga, Mihai Dragutescu, and Dan Mischianu. "The Control of Bloodloss During Percutanerous Nephrolithotomy Using Tranexamic Acid." Revista de Chimie 69, no. 10 (2018): 2728–30. http://dx.doi.org/10.37358/rc.18.10.6612.

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The aim of this study is to assess the efficiency and safety of the tranexamic acid in reducing hemmorrhagic complications and transfusion requirements in patients with renal lithiasis treated by percutaneous approach. Percutaneous nephrolithotomy (PCNL) is a minimally invasive technique used for large kidney stones (]20mm). Urinary sepsis and intra or postoperative bleeding are the very serious complications associated with this type of procedure. Tranexamic acid is used in the treatment of many haemorrhagic conditions. The experience with tranexamic acid in preventing bloodloss during percut

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Tencza, Elizabeth, Andrew J. Harrell, and Preeyaporn Sarangarm. "Effect of tranexamic acid administration time on blood product use in urban trauma patients." American Journal of Health-System Pharmacy 77, Supplement_2 (2020): S46—S53. http://dx.doi.org/10.1093/ajhp/zxaa074.

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Abstract Purpose To evaluate the effect of time to tranexamic acid administration on blood product usage in trauma patients and to assess the potential benefit of initiating a protocol for field administration by ground ambulance personnel. Methods Adult patients with traumatic injuries who received 1 g of tranexamic acid during the period January 2014 through June 2016 were retrospectively identified via review of automated dispensing cabinet and electronic medical record data and cross-referencing with the New Mexico Trauma Registry. Exclusion criteria included tranexamic acid use for nontra

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Timmy Wibisono, Budi Sutikno, Titiek Hidayati Ahadiah, Budi Utomo, and Citrawati Dyah Kenconowungu. "Comparison of the efficacy of hot saline irrigation and tranexamic acid on Boezaart score, intraoperative blood loss, and duration of surgery in functional endoscopic sinus surgery: a systematic review and meta-analysis." Bali Medical Journal 12, no. 2 (2023): 1414–20. http://dx.doi.org/10.15562/bmj.v12i2.4362.

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Link of Video Abstract: https://youtu.be/wEp6PioGVqw Background: Hot saline irrigation and tranexamic acid are techniques used to control bleeding during functional endoscopic sinus surgery (FESS). Hot saline irrigation and tranexamic acid can help control bleeding originating from microvascular located in the nasal cavity and paranasal sinuses. This study aims to compare the efficacy of these two techniques on Boezaart score, intraoperative blood loss, and duration of surgery in functional endoscopic sinus surgery. Methods: This study is an intervention meta-analysis, the research formulated

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Jawad, Ariana. "Tranexamic acid for antenatal bleeding of unknown origin in the second and third trimesters: A prospective clinical trial." Zanco Journal of Medical Sciences 25, no. 2 (2021): 532–43. http://dx.doi.org/10.15218/zjms.2021.017.

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Background and objective: Vaginal bleeding is a common complication in pregnancy and is associated with poor perinatal outcomes. This study aimed to determine the efficacy of tranexamic acid in stopping vaginal bleeding during pregnancy and improving perinatal outcomes. Methods: A prospective clinical trial was conducted on 137 pregnant women with vaginal bleeding of unknown causes in the second and third trimesters of pregnancy who were admitted to Maternity Teaching Hospital, Erbil city, Kurdistan region, Iraq from February 2016 to November 2019. Tranexamic acid was administered to one group

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Ergun, Bulent, Ercan Bastu, Mehmet Ozsurmeli, and Cem Celik. "Tranexamic Acid: A Potential Adjunct to Resectoscopic Endometrial Ablation." International Surgery 97, no. 4 (2013): 310–14. http://dx.doi.org/10.9738/cc149.1.

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Abstract Abnormal uterine bleeding (AUB) is a substantial cause of ill health in women worldwide. In this study, our aim was to evaluate the effectiveness of endometrial ablation using a modified urologic resectoscope along with tranexamic acid in AUB. Sixty patients were enrolled in this study. All patients underwent resectoscopic surgery. Patients were randomly divided into two groups. Group 1 (n = 30) received 500 mg of tranexamic acid. Group 2 (n = 30) served as the control group and underwent surgery without the administration of tranexamic acid. Total pictorial blood loss assessment char

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