Academic literature on the topic 'Transcobalamina'

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Journal articles on the topic "Transcobalamina"

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Ulleland, Marius, Ingar Eilertsen, Edward V. Quadros, et al. "Direct Assay for Cobalamin Bound to Transcobalamin (Holo-Transcobalamin) in Serum." Clinical Chemistry 48, no. 3 (2002): 526–32. http://dx.doi.org/10.1093/clinchem/48.3.526.

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Abstract Background: Only cobalamin carried by transcobalamin (holo-transcobalamin) is available for cellular uptake and hence is physiologically relevant. However, no reliable or accurate methods for quantifying holo-transcobalamin are available. We report a novel holo-transcobalamin assay based on solid-phase capture of transcobalamin. Methods: A monoclonal antibody specific for human transcobalamin with an affinity constant >1010 L/mol was immobilized on magnetic microspheres to capture and concentrate transcobalamin. The cobalamin bound to transcobalamin was then released and assaye
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Nexo, Ebba, Anna-Lisa Christensen, Torben E. Petersen, and Sergey N. Fedosov. "Measurement of Transcobalamin by ELISA." Clinical Chemistry 46, no. 10 (2000): 1643–49. http://dx.doi.org/10.1093/clinchem/46.10.1643.

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Abstract Background: Transcobalamin is essential for the cellular internalization of cobalamin. Methods to quantify the unsaturated protein are available, but few attempts have been made to develop methods to quantify the sum of unsaturated and cobalamin saturated transcobalamin. Methods: γ-Globulins from two polyclonal rabbit antibodies against recombinant human transcobalamin were used as capture and detection antibodies, and recombinant human transcobalamin was used as calibrator in an ELISA design. Results: The ELISA is specific for transcobalamin and has a detection limit of <1.6 p
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Uchiyama, Yukinobu. "Transcobalamin deficiency." SEIBUTSU BUTSURI KAGAKU 38, no. 6 (1994): 403–10. http://dx.doi.org/10.2198/sbk.38.403.

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Carmel, Ralph. "Measuring and Interpreting Holo-Transcobalamin (Holo-Transcobalamin II)." Clinical Chemistry 48, no. 3 (2002): 407–9. http://dx.doi.org/10.1093/clinchem/48.3.407.

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NIELSEN, RIKKE, BOE SANDAHL SØRENSEN, HENRIK BIRN, ERIK ILSØ CHRISTENSEN, and EBBA NEXØ. "Transcellular Transport of Vitamin B12in LLC-PK1 Renal Proximal Tubule Cells." Journal of the American Society of Nephrology 12, no. 6 (2001): 1099–106. http://dx.doi.org/10.1681/asn.v1261099.

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Abstract. The transcobalamin-vitamin B12complex is responsible for the transport of B12from plasma and into the tissues. The complex is filtered in the renal glomeruli and is a high-affinity ligand for the endocytic receptor megalin expressed in the proximal tubule. This study shows by the use of the proximal tubule LLC-PK1 cell line that transcobalamin-B12is internalized by megalin-mediated endocytosis. After endocytosis and accumulation in endosomes, transcobalamin is degraded and the B12molecule is released from the cells in complex with newly synthesized proteins. The release is polarized
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Hygum, Katrine, Dorte L. Lildballe, Eva H. Greibe, et al. "Mouse Transcobalamin Has Features Resembling both Human Transcobalamin and Haptocorrin." PLoS ONE 6, no. 5 (2011): e20638. http://dx.doi.org/10.1371/journal.pone.0020638.

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Schohn, H., J. L. Guéant, M. Girr, et al. "Synthesis and secretion of a cobalamin-binding protein by HT 29 cell line." Biochemical Journal 280, no. 2 (1991): 427–30. http://dx.doi.org/10.1042/bj2800427.

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An HT 29 cell line derived from human colonic carcinoma was shown to synthesize and release a cobalamin-binding protein. The cobalamin-binding protein was classified as transcobalamin (TC). By gel filtration on Sephacryl S200 HR, we observed that the secreted protein bound to cobalamin had the same size as plasma transcobalamin. Like transcobalamin, the cobalamin-binding protein bound cobalamin but not cobinamide. Purification of the cobalamin-binding protein was performed by heparin-Sepharose affinity chromatography and by Sephacryl S200 gel filtration. The molecular mass of the purified prot
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van Asselt, Dieneke Z. B., Chris M. G. Thomas, Martin F. G. Segers, Henk J. Blom, Ron A. Wevers, and Willibrord H. L. Hoefnagels. "Cobalamin-binding proteins in normal and cobalamin-deficient older subjects." Annals of Clinical Biochemistry: International Journal of Laboratory Medicine 40, no. 1 (2003): 65–69. http://dx.doi.org/10.1258/000456303321016187.

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Background: The causes of cobalamin (vitamin B12) deficiency in older people are only partly understood. We investigated the role of the cobalamin-binding proteins and tested the hypothesis that low saturated transcobalamin concentration is an early marker of cobalamin deficiency. Methods: We measured saturated (holo) and unsaturated (apo) transcobalamin and haptocorrin concentrations in healthy middle-aged volunteers, healthy older volunteers, cobalamin-deficient older volunteers and cobalamin-deficient older patients. Results: Holo and apo concentrations of transcobalamin and haptocorrin wer
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McCaddon, Andrew, Kaj Blennow, Peter Hudson, et al. "Transcobalamin Polymorphism and Serum Holo-Transcobalamin in Relation to Alzheimer’s Disease." Dementia and Geriatric Cognitive Disorders 17, no. 3 (2004): 215–21. http://dx.doi.org/10.1159/000076359.

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Abuyaman, Omar, Niels Torring, Rima Obeid, and Ebba Nexo. "First trimester serum levels of the soluble transcobalamin receptor, holo-transcobalamin, and total transcobalamin in relation to preeclampsia risk." Scandinavian Journal of Clinical and Laboratory Investigation 76, no. 8 (2016): 641–44. http://dx.doi.org/10.1080/00365513.2016.1230885.

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Dissertations / Theses on the topic "Transcobalamina"

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Lazaro, Robson José. "Associação entre os polimorfismos nos genes da Transcobalamina II (TCN2 c.776C>G e TC2 c. 67A>G) e da metilenotetraidrofolato redutase (MTHFR c.677C>T) e o risco de ter abortos espontâneos recorrentes." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9136/tde-01072015-122926/.

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O aborto espontâneo recorrente (AER) é definido pela ocorrência de três ou mais abortos espontâneos consecutivos com idade gestacional de até 20 semanas. O AER é um evento multifatorial, tem um índice de elucidação da causa na ordem de 50% e, mesmo com os avanços da medicina diagnóstica ainda assim 40% dos casos permanecem com sua causa desconhecida. O crescimento fetal é totalmente dependente do aporte de nutrientes oirundos da mãe, dentre esses nutrientes a cobalamina e o ácido fólico desempenham um papel fundamental para a viabilidade fetal. O objetivo geral deste estudo foi investigar se e
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Schohn, Hervé. "Purification et caractérisation des protéines entérocytaires impliquées dans l'absorption de la vitamine B12 (récepteur du facteur intrinsèque et transcobalamine) dans l'intestin mature et fœtal." Nancy 1, 1990. http://www.theses.fr/1990NAN10399.

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Nous avons étudié 2 protéines impliquées dans l'absorption iléale de la vitamine B12 ou cobalamine : le récepteur du complexe facteur intrinsèque-cobalamine et la transcobalamine. Le récepteur du complexe facteur intrinsèque-cobalamine est exprimé dès la dixième semaine du développement fœtal chez l'homme. Le récepteur iléal porcin a été purifié par chromatographie d'affinité sur un support sépharose-facteur intrinsèque. Il se compose de 4 polypeptides dont trois sont glycosyles. La liaison entre le récepteur et son ligand peut être inhibé en présence d'agglutinine de germe de blé. L'inhibitio
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Semmler, Alexander, Michael Linnebank, Dietmar Krex, et al. "Polymorphisms of Homocysteine Metabolism Are Associated with Intracranial Aneurysms." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-135282.

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Background: Impaired homocysteine metabolism is associated with a number of vasculopathies including extracranial aneurysms. We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms. Methods: Caucasian patients (n = 255) treated at two German hospitals for intracranial aneurysms and local controls (n = 348) were genotyped for the following polymorphisms: methionine synthase (MTR) c.2756A→G, methylenetetrahydrofolate reductase (MTHFR) c.677C→T, MTHFR c.1298A→C, cystathionine β-synthase (CBS) c.844_855ins68, CBS c.833T
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Yamani, Lama. "Studies on transcobalamin in cultured fibroblasts from patients with inborn errors of cobalamin metabolism." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112320.

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Cobalamin must be metabolized intracellularly in order to bind two enzymes: methionine synthase in cytoplasm and methylmalonyl-CoA mutase in mitochondria. Defects in this process cause different inborn errors of cobalamin metabolism (cblA-cblG and mut). A previous study described a cobalamin-binding protein, in addition to methylmalonyl-CoA mutase, in crude mitochondrial fractions. The amount of [57Co]cobalamin bound to this protein was increased in cblB, mut and cblD variant2 cell lines, compared to control cell lines. In the present study, this protein was identified as transcobalamin (TC).
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Semmler, Alexander, Michael Linnebank, Dietmar Krex, et al. "Polymorphisms of Homocysteine Metabolism Are Associated with Intracranial Aneurysms." Karger, 2008. https://tud.qucosa.de/id/qucosa%3A27635.

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Background: Impaired homocysteine metabolism is associated with a number of vasculopathies including extracranial aneurysms. We analyzed the possible association of nine genetic variants of homocysteine metabolism with the occurrence of intracranial aneurysms. Methods: Caucasian patients (n = 255) treated at two German hospitals for intracranial aneurysms and local controls (n = 348) were genotyped for the following polymorphisms: methionine synthase (MTR) c.2756A→G, methylenetetrahydrofolate reductase (MTHFR) c.677C→T, MTHFR c.1298A→C, cystathionine β-synthase (CBS) c.844_855ins68, CBS c.833T
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Namour, Bernard. "Phénotypes et concentrations relatives des isoprotéines de la transcobalamine II rapportés au polymorphisme Arg/Pro du codon 259." Nancy 1, 1999. http://www.theses.fr/1999NAN19901.

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Boukhzer, El Bachir. "Caractérisation d'un récepteur membranaire de la transcobalamine II au niveau des cellules de la ligne germinale mâle du lapin." Nancy 1, 1995. http://docnum.univ-lorraine.fr/public/SCD_T_1995_0447_BOUKHZER.pdf.

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Dans les années 60 Sharp et Witts, Watson et Morales, ainsi que Griswold démontrent que la vitamine B 12 influence la spermatogenèse. Les stérilités observées, chez les patients des deux sexes atteints d'anémie pernicieuse, peuvent être surmontées par une thérapie à la vitamine B12. L'aspect biochimique de cette stérilité, les cellules cibles concernées et le rôle joué par la vitamine B12 , demeurèrent inconnues. Le but de cette étude a été de rechercher et de caractériser le récepteur du complexe transcobalamine-vitamine B12 au niveau des cellules germinales mâles. La présence de récepteurs d
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Hannibal, Luciana. "Intracellular Processing of Cobalamins in Mammalian Cells." Kent State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=kent1247938485.

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Schrempf, Robert [Verfasser]. "Stoffwechselaktives, Transcobalamin-II-gebundenes Vitamin B12 im Vergleich zum gesamten Vitamin B12 : ein neuer Labortest / vorgelegt von Robert Schrempf." 2004. http://d-nb.info/973286288/34.

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Book chapters on the topic "Transcobalamina"

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Hitzig, W. H., Marijke Fràter-Schröder, and R. Seger. "Immunodeficiency Due to Transcobalamin II Deficiency." In Ciba Foundation Symposium 68 - Enzyme Defects and Immune Dysfunction. John Wiley & Sons, Ltd., 2008. http://dx.doi.org/10.1002/9780470720516.ch6.

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Adkins, Yuriko, and Bo Lönnerdal. "Binding of Transcobalamin II by Human Mammary Epithelial Cells." In Advances in Experimental Medicine and Biology. Springer US, 2001. http://dx.doi.org/10.1007/978-1-4615-1371-1_58.

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Hassan, Ian F., Ian J. Parsons, and Martin W. Mackay. "Receptor-Mediated Transport of Cobalamin in Caco-2 Cells: Intracellular Localisation of Transcobalamin II." In Pharmaceutical Applications of Cell and Tissue Culture to Drug Transport. Springer New York, 1991. http://dx.doi.org/10.1007/978-1-4757-0286-6_9.

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Rodan, Lance Harrington, Navin Mishra, Ivanna Yau, Andrea Andrade, Komudi Siriwardena, and Ingrid Tein. "Expanding the Spectrum of Methylmalonic Acid-Induced Pallidal Stroke: First Reported Case of Metabolic Globus Pallidus Stroke in Transcobalamin II Deficiency." In JIMD Reports. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/8904_2013_215.

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"Transcobalamin." In Springer Reference Medizin. Springer Berlin Heidelberg, 2019. http://dx.doi.org/10.1007/978-3-662-48986-4_313712.

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"Transcobalamin (TCN1)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_17182.

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"Transcobalamin (TC2)." In Encyclopedia of Genetics, Genomics, Proteomics and Informatics. Springer Netherlands, 2008. http://dx.doi.org/10.1007/978-1-4020-6754-9_17183.

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"TCN2: Transcobalamin II." In Encyclopedia of Medical Immunology. Springer New York, 2020. http://dx.doi.org/10.1007/978-1-4614-8678-7_300345.

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Seetharam, Bellur, and Ning Li. "Transcobalamin II and its cell surface receptor." In Vitamins & Hormones. Elsevier, 2000. http://dx.doi.org/10.1016/s0083-6729(00)59012-8.

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Rothenberg, Sheldon P., and Edward V. Quadros. "Quantitative methods for measurement of transcobalamin II." In Methods in Enzymology. Elsevier, 1997. http://dx.doi.org/10.1016/s0076-6879(97)81032-4.

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