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1

International Symposium on Transcranial Magnetic Stimulation (2nd 2003 Göttingen, Germany). Transcranial magnetic stimulation and transcranial direct current stimulation: Proceedings of the 2nd International Transcranial Magnetic Stimulation (TMS) and Transcranial Direct Current Stimulation (tDCS) Symposium, Göttingen, Germany, 11-14 June 2003. Amsterdam: Elsevier, 2003.

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2

Brunoni, André R., Michael A. Nitsche, and Colleen K. Loo, eds. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-76136-3.

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3

Brunoni, André, Michael Nitsche, and Colleen Loo, eds. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-33967-2.

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4

Knotkova, Helena, Michael A. Nitsche, Marom Bikson, and Adam J. Woods, eds. Practical Guide to Transcranial Direct Current Stimulation. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-319-95948-1.

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5

Nitsche, Michael A., Andrea Antal, David Liebetanz, Nicolas Lang, Frithjof Tergau, and Walter Paulus. Neuroplasticity induced by transcranial direct current stimulation. Edited by Charles M. Epstein, Eric M. Wassermann, and Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0017.

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This article explores the use of brain stimulation as a tool of neuroplasticity. Recent studies have shown that brain stimulation with weak direct currents is a technique used to generate prolonged modifications of cortical excitability and activity. Transcranial direct current stimulation (tDCS) generates modulations of excitability. The efficacy of electric brain stimulation is defined by the combination of strength of current, size of stimulated area, and stimulation duration. The two main fields of clinical application on tDCS are: the exploration of pathological alterations of neuroplasticity in neurological and psychiatric diseases, and the evaluation of a possible clinical benefit of tDCS in these diseases. Further studies are needed to explore this area if prolonged, repetitive, or stronger stimulation protocols, for which safety has to be assured, could evolve into clinically more relevant improvement. This article reinforces the fact that brain stimulation with weak direct currents could evolve as a promising tool in neuroplasticity research.
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6

Transcranial Magnetic Stimulation and Transcranial Direct Current Stimulation, Proceedings of the 2nd International Transcranial Magnetic Stimulation (TMS) and Transcranial Direct Current Stimulation (tDCS) Symposium. Elsevier, 2003. http://dx.doi.org/10.1016/s1567-424x(09)x7005-4.

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7

Rotenberg, Alexander, Alvaro Pascual-Leone, and Alan D. Legatt. Transcranial Electrical and Magnetic Stimulation. Edited by Donald L. Schomer and Fernando H. Lopes da Silva. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780190228484.003.0028.

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Noninvasive magnetic and electrical stimulation of cerebral cortex is an evolving field. The most widely used variant, transcranial electrical stimulation (TES), is routinely used for intraoperative monitoring. Transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) are emerging as clinical and experimental tools. TMS has gained wide acceptance in extraoperative functional cortical mapping. TES and TMS rely on pulsatile stimulation with electrical current intensities sufficient to trigger action potentials within the stimulated cortical volume. tDCS, in contrast, is based on neuromodulatory effects of very-low-amplitude direct current conducted through the scalp. tDCS and TMS, particularly when applied in repetitive trains, can modulate cortical excitability for prolonged periods and thus are either in active clinical use or in advanced stages of clinical trials for common neurological and psychiatric disorders such as major depression and epilepsy. This chapter summarizes physiologic principles of transcranial stimulation and clinical applications of these techniques.
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8

Priori, Alberto, Andre R. Brunoni, Felipe Fregni, Paulo S. Boggio, and Roberta Ferrucci, eds. The frontiers of clinical research on transcranial direct current stimulation (tDCS) in Neuropsychiatry. Frontiers Media SA, 2015. http://dx.doi.org/10.3389/978-2-88919-287-8.

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9

Brunoni, Andre Russowsky, Bernardo de Sampaio Pereira Júnior, and Izio Klein. Neuromodulatory approaches for bipolar disorder: current evidences and future perspectives. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198748625.003.0028.

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Bipolar disorder is a prevalent condition, with few therapeutic options and a high degree of refractoriness. This justifies the development of novel non-pharmacological treatment strategies, such as the non-invasive techniques of transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS), as well as the invasive techniques of deep brain stimulation (DBS) and vagus nerve stimulation (VNS). In this chapter, we provide a summary of the development of the techniques as well as the studies carried out with patients with bipolar disorder. Although many promising results regarding the efficacy of theses techniques were described, the total number of studies is still low, highlighting the need of further studies in larger samples as to provide a definite picture regarding the use of clinical neuromodulation in bipolar disorder.
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10

Gad, Heba, Daniel Bateman, and Paul E. Holtzheimer. Neurostimulation Therapies, Side Effects, Risks, and Benefits. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199374656.003.0016.

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Neurostimulation therapies are an alternative for non-responders to pharmacological or psychotherapy management, as well as when first-line treatments are contraindicated for treatment of neuropsychiatric disorders in the elderly. Brain stimulation treatments for neuropsychiatric disorders include the following FDA approved treatments for major depressive disorder: electroconvulsive therapy (ECT), which remains one of the most effective therapies for several neuropsychiatric disorders; repetitive transcranial magnetic stimulation (rTMS); and vagus nerve stimulation (VNS). Deep brain stimulation (DBS);magnetic seizure therapy (MST); transcranial direct-current stimulation (tDCS); and direct cortical stimulation (DCS) are not currently FDA approved. These techniques are reviewed in this chapter with special attention to their application in older adults. Medicolegal issues of informed consent and substituted decisions for procedures are also discussed.
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11

Hallett, Mark, and Alfredo Berardelli. Movement Disorders. Edited by Charles M. Epstein, Eric M. Wassermann, and Ulf Ziemann. Oxford University Press, 2012. http://dx.doi.org/10.1093/oxfordhb/9780198568926.013.0044.

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This article focuses on the potential therapeutic uses of transcranial magnetic stimulation (TMS) in movement disorders. The brain can be stimulated with low levels of direct electrical current, called direct current polarization (tDCS). High-frequency repetitive TMS might increase brain excitability and be used for therapy in Parkinson's disease. Single sessions with TMS, however, have not proven to be very effective. Treatment with tDCS has been performed in some open studies with some success, but these results need confirmation. Physiological findings in dystonia reveal a decrease in intracortical inhibition. There have been a few studies of patients with Tourette's syndrome with mixed results. To date, clinical results with TMS in movement disorders have been mixed, and more work will be needed to clarify the potential clinical role of TMS.
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12

Lustig, Daphne. Untersuchung nicht-fokaler Exzitabilität bei schizophrenen Patienten mittels transkranieller Gleichstromstimulation: Transcranial Direct Curent Stimulation - tDCS. 2014.

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13

Rogers, Lionel. Transcranial Direct Current Stimulation: Emerging Uses, Safety and Neurobiological Effects. Nova Science Publishers, Incorporated, 2016.

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14

Knotkova, Helena, Michael A. Nitsche, Marom Bikson, and Adam J. Woods. Practical Guide to Transcranial Direct Current Stimulation: Principles, Procedures and Applications. Springer, 2019.

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15

Brunoni, André, Michael Nitsche, and Colleen Loo. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: Clinical Principles and Management. Springer, 2016.

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16

Brunoni, André, Michael Nitsche, and Colleen Loo. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: Clinical Principles and Management. Springer London, Limited, 2016.

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17

Nitsche, Michael A., André Brunoni, and Colleen Loo. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: Clinical Principles and Management. Springer International Publishing AG, 2021.

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18

Brunoni, André, Michael Nitsche, and Colleen Loo. Transcranial Direct Current Stimulation in Neuropsychiatric Disorders: Clinical Principles and Management. Springer, 2018.

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19

Reidler, Jay S. Modulation of Pain with Transcranial Direct Current Stimulation and Diffuse Noxious Inhibitory Controls. 2014.

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20

Chrysikou, Evangelia G., Marian E. Berryhill, Marom Bikson, and H. Branch Coslett, eds. Revisiting the Effectiveness of Transcranial Direct Current Brain Stimulation for Cognition: Evidence, Challenges, and Open Questions. Frontiers Media SA, 2017. http://dx.doi.org/10.3389/978-2-88945-325-2.

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21

Zohuri, Bahman, and Patrick J. McDaniel. Electrical Brain Stimulation for the Treatment of Neurological Disorders. Taylor & Francis Group, 2021.

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22

Electrical Brain Stimulation for the Treatment of Neurological Disorders. Apple Academic Press, Incorporated, 2019.

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23

McDaniel, Patrick, and Bahman Zohuri. Electrical Brain Stimulation for the Treatment of Neurological Disorders. Apple Academic Press, Incorporated, 2019.

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24

Zohuri, Bahman, and Patrick J. McDaniel. Electrical Brain Stimulation for the Treatment of Neurological Disorders. Apple Academic Press, Incorporated, 2019.

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25

Hao, Joy, Rae Lynne Kinler, Eliezer Soto, Helena Knotkova, and Ricardo A. Cruciani. Neurostimulation in pain management. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199656097.003.0099.

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Neurostimulation describes an array of interventions that involve targeted stimulation of peripheral nerve, spinal cord, or the brain. Although few high-quality studies of neurostimulation techniques have been done and the techniques are seldom used in the management of pain related to serious illness, a better understanding of the available treatments and the emergence of newer technologies may increase access and use in the future. Transcutaneous electrical nerve stimulation is considered to be safe and may be used as an adjunct to pharmacotherapy in the routine management of chronic pain. Concerns about electrode placement near tumour masses continue, however, despite reassuring data, and for now, this approach should be used cautiously in those with metastatic disease. The recent advent of non-invasive central nervous system neurostimulation therapies-transcranial direct current stimulation and transcranial magnetic stimulation-offers promising new treatments for pain.
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