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Dissertations / Theses on the topic 'Transcription activator-like effectors'

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Published: 4 June 2021
Last updated: 1 February 2022

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1

Zhang, Junli. "Functional analysis of bacterial TAL effectors and the targeted susceptibility genes in plants." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/20361.

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Doctor of Philosophy<br>Department of Plant Pathology<br>Frank White<br>The genus Xanthomonas consists of bacterial species causing economically important plant diseases in major crops. In a wide variety of Xanthamonas species, the transcription activator-like (TAL) effectors (proteins) are synthesized and secreted into host cells, whereby they enter the plant nucleus. TAL effectors bind specific host gene promoters, inducing the expression of the targeted genes, which in some cases leads to either resistance or an enhanced state of disease susceptibility. The TAL effectors in individual Xanth
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2

Maeder, Morgan Lee. "Engineered DNA-Binding Proteins for Targeted Genome Editing and Gene Regulation." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10770.

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Engineered DNA-binding proteins enable targeted manipulation of the genome. Zinc fingers are the most well characterized DNA-binding domain and for many years research has focused on understanding and manipulating the sequence-specificities of these proteins. Recently, major advances in the ability to engineer zinc finger proteins, as well as the discovery of a new class of DNA-binding domains - transcription activator-like effectors (TALEs), have made it possible to rapidly and reliably engineer proteins targeted to any sequence of interest. With this capability, focus has shifted to explo
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3

Gieß, Mario David [Verfasser], Daniel [Akademischer Betreuer] Summerer, and Daniel [Gutachter] Rauh. "Chemoselective conjugation strategies for the programmable detection of epigenetic cytosine 5-modifications with transcription activator-like effectors / Mario David Gieß ; Gutachter: Daniel Rauh ; Betreuer: Daniel Summerer." Dortmund : Universitätsbibliothek Dortmund, 2019. http://d-nb.info/1195777272/34.

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4

Gieß, Mario [Verfasser], Daniel [Akademischer Betreuer] Summerer, and Daniel [Gutachter] Rauh. "Chemoselective conjugation strategies for the programmable detection of epigenetic cytosine 5-modifications with transcription activator-like effectors / Mario David Gieß ; Gutachter: Daniel Rauh ; Betreuer: Daniel Summerer." Dortmund : Universitätsbibliothek Dortmund, 2019. http://d-nb.info/1195777272/34.

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5

Waltl, Laura [Verfasser]. "Generation and characterization of transcription activator-like effector nucleases / Laura Waltl." Gießen : Universitätsbibliothek, 2016. http://d-nb.info/1102854069/34.

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6

Kubik, Grzegorz [Verfasser]. "Deciphering Epigenetic Cytosine Modifications with Transcription Activator Like Effector Proteins / Grzegorz Kubik." Konstanz : Bibliothek der Universität Konstanz, 2016. http://d-nb.info/1112337008/34.

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7

辻, 将吾. "分子進化法によるTranscription activator-like effectorの機能拡張". 京都大学 (Kyoto University), 2017. http://hdl.handle.net/2433/225531.

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8

Habierski, Andre [Verfasser]. "Die in vitro-Modifikation des kaninen ß-Galaktosidase-Gens mittels Zinkfingernukleasen und transcription activator like effector nucleases / Andre Habierski." Hannover : Bibliothek der Tierärztlichen Hochschule Hannover, 2014. http://d-nb.info/106486306X/34.

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9

Moreira, Catarina Alfaya. "DESENVOLVIMENTO DE PROTEÍNA SINTÉTICA QUIMÉRICA BASEADA EM TALE (TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR) PARA APLICAÇÃO EM SISTEMA BIOSSENSOR DE DNA. 72f 2017." Instituto de Ciências da Saúde, 2017. http://repositorio.ufba.br/ri/handle/ri/25293.

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Submitted by Hiolanda Rêgo (hiolandarego@gmail.com) on 2018-02-05T18:15:30Z No. of bitstreams: 1 Dissertação_ICS_Catarina Alfaya Moreira.pdf: 3840507 bytes, checksum: 842c5cfecee2c3b039e0c031feb67016 (MD5)<br>Made available in DSpace on 2018-02-05T18:15:30Z (GMT). No. of bitstreams: 1 Dissertação_ICS_Catarina Alfaya Moreira.pdf: 3840507 bytes, checksum: 842c5cfecee2c3b039e0c031feb67016 (MD5)<br>As abordagens de Biologia Sintética possuem potencial de aumentar a produção de ferramentas diagnósticas adequadas para utilização na prática, como os biossensores de DNA. O controle dos sistemas biol
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10

Rathi, Preeti [Verfasser], Daniel [Akademischer Betreuer] Summerer, and Leif [Gutachter] Dehmelt. "Isolation of genomic DNA sequences with expanded nucleobase selectivity using Transcription Activator-Like Effector Proteins / Preeti Rathi ; Gutachter: Leif Dehmelt ; Betreuer: Daniel Summerer." Dortmund : Universitätsbibliothek Dortmund, 2017. http://d-nb.info/1160443246/34.

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11

Peng, Zhao. "Contribution of TAL effectors in Xanthomonas to diseases of rice and wheat." Diss., Kansas State University, 2015. http://hdl.handle.net/2097/20443.

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Doctor of Philosophy<br>Plant Pathology<br>Frank F. White<br>Rice and wheat are two major crops that suffer losses from the diseases of bacterial blight and bacterial leaf streak, which are caused by Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas translucens pv. undulosa (Xtu), respectively. Transcriptional-Activator Like (TAL) effectors, a special family of type III effector proteins from Xanthomonas, have been demonstrated as critical virulence factors that act by inducing corresponding susceptibility (S) genes in several disease complexes of plants. In this study, I analyzed the contri
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12

Fischer, Stefan Markus [Verfasser]. "Designer Transcription Activator Like Effector - Chromatin Affinity Purification (dTALE-ChAP) a novel in planta method to unravel the protein coverage at a promoter of choice / Stefan Markus Fischer." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1217249273/34.

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13

Wibowo, Anjar. "Transcription Activator-Like Effectors (TALEs) Hybrid Nucleases for Genome Engineering Application." Thesis, 2011. http://hdl.handle.net/10754/209404.

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Gene targeting is a powerful genome engineering tool that can be used for a variety of biotechnological applications. Genomic double-strand DNA breaks generated by engineered site-specific nucleases can stimulate gene targeting. Hybrid nucleases are composed of DNA binding module and DNA cleavage module. Zinc Finger Nucleases were used to generate double-strand DNA breaks but it suffers from failures and lack of reproducibility. The transcription activator–like effectors (TALEs) from plant pathogenic Xanthomonas contain a unique type of DNA-binding domain that bind specific DNA targets. The pu
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14

Piatek, Marek J. "In silico engineering and optimization of Transcription Activator-Like Effectors and their derivatives for improved DNA binding predictions." Diss., 2015. http://hdl.handle.net/10754/583278.

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Transcription Activator-Like Effectors (TALEs) can be used as adaptable DNAbinding modules to create site-specific chimeric nucleases or synthetic transcriptional regulators. The central repeat domain mediates specific DNA binding via hypervariable repeat di-residues (RVDs). This DNA-Binding Domain can be engineered to bind preferentially to any user-selected DNA sequence if engineered appropriately. Therefore, TALEs and their derivatives have become indispensable molecular tools in site-specific manipulation of genes and genomes. This thesis revolves around two problems: in silico desi
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15

Kaldine, Haajira. "Liver-targeted transcription activator-like effector repressors that inactivate HBV cccDNA." Thesis, 2017. https://hdl.handle.net/10539/24730.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfillment of the requirements for the degree of Master of Science in Medicine Johannesburg, 2017.<br>The hepatitis B virus (HBV) continues to be a global health threat as chronic infection may lead to cirrhosis and hepatocellular carcinoma (HCC). Current treatments are limited in efficacy and do not target the stable HBV covalently closed circular DNA (cccDNA) minichromosome which forms the template for viral replication and is responsible for persistence of the infection. Using gene editing te
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16

Smith, Tiffany Shenay. "Generating obligate heterodimeric transcription activator-like effector nucleases to inactive hepatitis B viral replication." Thesis, 2018. https://hdl.handle.net/10539/25377.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfilment of the requirements for the degree of Master of Science in Medicine Johannesburg, 2018.<br>The hepatitis B virus (HBV) remains a global health concern as chronic infection can lead to cirrhosis and hepatocellular carcinoma. Current therapies are only partially effective and do not target the HBV covalently closed circular DNA (cccDNA). cccDNA serves as a replication intermediate for the transcription of viral RNA, resulting in the persistence of infection. Several designer nucleases h
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17

"Efficient targeted gene disruption in Xenopus embryos using engineered transcription activator-like effector nucleases (TALENs)." 2013. http://library.cuhk.edu.hk/record=b5549736.

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非洲爪蛙(Xenopus laevis)和熱帶爪蛙(Xenopus tropicalis)是經典的模式動物，廣泛應用於胚胎學，發育生物學和人類疾病模型研究領域。然而，由於缺乏有效地同源重組技術和胚胎幹細胞誘導技術，在上述兩種模式動物中很難通過定點突變研究特定基因的功能。這些技術瓶頸制約其在遺傳學研究方面的應用。近來，通過鋅指核酸酶(ZFNs)和類轉錄激活因子效應物核酸酶(TALENs)介導的特異性基因突變技術成功地應用於各種模式動物模型，包括：線蟲、斑馬魚和大鼠。鋅指核酸酶和TALENs核酸酶都是由可編碼設計的DNA結合功能域和非特異性FokI核酸酶的功能域組成的人工構建DNA核酸酶。結合到相鄰DNA位點的鋅指核酸酶或TALENs核酸酶的單體通過FokI功能域結合形成二聚體，從而啟動其核酸酶活性，在預設靶點產生DNA雙鏈斷裂 (double-strand breaks)。通常，非同源末端連接(NHEJ)在修復DNA雙鏈斷裂過程中會導致缺失或者插入突變(indel)。在此研究中，我們在世界上首次利用TALENs核酸酶在爪蛙胚胎中高效誘導產生體細胞突變。我們優化了Golden Gate TALENs核酸酶的拼接方法，使其便於體外RNA轉錄和顯微注射到爪蛙胚胎中。我們還利用基於聚合酶鏈式反應(PCR)的檢測方法，用於檢測基因突變效率。我們設計八對TALENs核酸酶，它們分別靶向識別爪蛙中
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18

Pei-YuWu and 吳佩諭. "Editing of mitochondrial nad1 gene in plants by using transcription activator-like effector nuclease（TALEN）technology." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/k2yd3y.

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19

Yuan-LinSu and 蘇源霖. "A study to modify tobacco chloroplast DNA sequence by nuclear transformation of transcription activator like effector nuclease (TALEN) gene." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/qb5346.

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碩士<br>國立成功大學<br>生物科技研究所<br>104<br>To edit the plastid DNA, biolistic bombardment is the most common used method to deliver expression vectors into plastid, and then the transgene could integrate into plastid genome via homologous recombination. Under subsequently long selection and regeneration process, the transplastomic plant could be obtained. However, biolistic bombardment is costly and selection/regeneration process is time consuming. To specifically and easily edit the plastid DNA, in this study, a pair of transcription activator like effector nuclease (TALENs) was stablely or transientl
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20

Singh, Prashika. "Targeted inactivation of hepatitis B virus genome using enhanced transcription activator-like effector nucleases containing a sharkey fokI nuclease domain." Thesis, 2018. https://hdl.handle.net/10539/25431.

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A dissertation submitted to the Faculty of Health Sciences, University of the Witwatersrand, in fulfilment of the requirements for the degree of Master of Science in Medicine. Johannesburg, 2018.<br>Despite the availability of an effective vaccine, hepatitis B virus (HBV) infections are a major public health problem with approximately two thirds of the world’s population having been exposed to this virus. This DNA virus infects hepatocytes causing inflammation and is the causative agent of hepatitis B. Upon infection the viral genome is transported to the nucleus and repaired to covalently c
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