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Journal articles on the topic 'Transcription activator-like effectors'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Kim, Jung-Gun, and Mary Beth Mudgett. "Tomato bHLH132 Transcription Factor Controls Growth and Defense and Is Activated by Xanthomonas euvesicatoria Effector XopD During Pathogenesis." Molecular Plant-Microbe Interactions® 32, no. 12 (2019): 1614–22. http://dx.doi.org/10.1094/mpmi-05-19-0122-r.

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Effector-dependent manipulation of host transcription is a key virulence mechanism used by Xanthomonas species causing bacterial spot disease in tomato and pepper. Transcription activator-like (TAL) effectors employ novel DNA-binding domains to directly activate host transcription, whereas the non-TAL effector XopD uses a small ubiquitin-like modifier (SUMO) protease activity to represses host transcription. The targets of TAL and non-TAL effectors provide insight to the genes governing susceptibility and resistance during Xanthomonas infection. In this study, we investigated the extent to whi

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2

Moore, Richard, Anita Chandrahas, and Leonidas Bleris. "Transcription Activator-like Effectors: A Toolkit for Synthetic Biology." ACS Synthetic Biology 3, no. 10 (2014): 708–16. http://dx.doi.org/10.1021/sb400137b.

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3

Erkes, Annett, Maik Reschke, Jens Boch, and Jan Grau. "Evolution of Transcription Activator-Like Effectors in Xanthomonas oryzae." Genome Biology and Evolution 9, no. 6 (2017): 1599–615. http://dx.doi.org/10.1093/gbe/evx108.

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4

Maurer, Sara, Benjamin Buchmuller, Christiane Ehrt, Julia Jasper, Oliver Koch, and Daniel Summerer. "Overcoming conservation in TALE–DNA interactions: a minimal repeat scaffold enables selective recognition of an oxidized 5-methylcytosine." Chemical Science 9, no. 36 (2018): 7247–52. http://dx.doi.org/10.1039/c8sc01958d.

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5

Ma, Wenbo, Yuanchao Wang, and John McDowell. "Focus on Effector-Triggered Susceptibility." Molecular Plant-Microbe Interactions® 31, no. 1 (2018): 5. http://dx.doi.org/10.1094/mpmi-11-17-0275-le.

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Effector biology exhibits diversity at every level. Effector proteins play key roles in the molecular interplay between plants and plant-associated organisms, and effector biology remains one of the most active areas in the research field of molecular plant-microbe interactions. Using effectors as probes, much has been learned about pathogen virulence and host immunity, which has broad implications in developing disease-resistant crops that are essential for global food security. Thus, the MPMI Editorial Board is publishing this Focus Issue to showcase recent progress in this area. Additional

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6

Scott, James N. F., Adam P. Kupinski, and Joan Boyes. "Targeted genome regulation and modification using transcription activator-like effectors." FEBS Journal 281, no. 20 (2014): 4583–97. http://dx.doi.org/10.1111/febs.12973.

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7

Lebar, Tina, Anže Verbič, Ajasja Ljubetič, and Roman Jerala. "Polarized displacement by transcription activator-like effectors for regulatory circuits." Nature Chemical Biology 15, no. 1 (2018): 80–87. http://dx.doi.org/10.1038/s41589-018-0163-8.

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8

Geiger-Schuller, Kathryn, and Doug Barrick. "Broken TALEs: Transcription Activator-like Effectors Populate Partly Folded States." Biophysical Journal 111, no. 11 (2016): 2395–403. http://dx.doi.org/10.1016/j.bpj.2016.10.013.

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9

Khojasteh, Moein, Syed Mashab Ali Shah, Fazal Haq, et al. "Transcription Activator-Like Effectors Diversity in Iranian Strains of Xanthomonas translucens." Phytopathology® 110, no. 4 (2020): 758–67. http://dx.doi.org/10.1094/phyto-11-19-0428-r.

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Bacterial leaf streak caused by different pathovars of Xanthomonas translucens is the most important seedborne bacterial disease of small grain cereals. However, variations in the virulence-associated genomic areas of the pathogen remain uninvestigated. In this study, the diversity of transcription activator-like effectors (TALE) was investigated using the Southern blotting of BamHI-digested genomic DNAs in the Iranian strains of X. translucens. All 65 X. translucens strains were assigned into 13 genotypes, where 57 X. translucens pv. undulosa strains were placed in genotypes 1 to 8, and seven

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10

Wang, Juan, Avtar Singh, Fabio Cupri Rinaldi, John Lis, Adam Bogdanove, and Warren Zipfel. "Visualizing Specific Genomic Loci using Fluorescently Labeled Transcription Activator-Like Effectors." Biophysical Journal 110, no. 3 (2016): 649a—650a. http://dx.doi.org/10.1016/j.bpj.2015.11.3475.

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11

Tsuji, Shogo, and Miki Imanishi. "Modified nucleobase-specific gene regulation using engineered transcription activator-like effectors." Advanced Drug Delivery Reviews 147 (July 2019): 59–65. http://dx.doi.org/10.1016/j.addr.2019.08.011.

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12

Kawata, Viviane, Adam Wilkinson, Xuefei Gau, et al. "Perturbing haematopoietic transcription factor networks and cell fate decisions using transcriptional activator-like effectors." Experimental Hematology 41, no. 8 (2013): S71. http://dx.doi.org/10.1016/j.exphem.2013.05.277.

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13

XU, Zheng-yin, Li-fang ZOU, Wen-xiu MA, Lu-lu CAI, Yang-yang YANG, and Gong-you CHEN. "Action modes of transcription activator-like effectors (TALEs) of Xanthomonas in plants." Journal of Integrative Agriculture 16, no. 12 (2017): 2736–45. http://dx.doi.org/10.1016/s2095-3119(17)61750-7.

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14

Renner, Ivonne, Nancy Funk, Rene Geissler, Susann Friedrich, Anika Penzel, and Sven-Erik Behrens. "Antiviral Interferon-Beta Signaling Induced by Designed Transcription Activator-Like Effectors (TALE)." PLoS ONE 9, no. 12 (2014): e114288. http://dx.doi.org/10.1371/journal.pone.0114288.

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15

Shen, D. K., D. Filopon, L. Kuhn, B. Polack, and B. Toussaint. "PsrA Is a Positive Transcriptional Regulator of the Type III Secretion System in Pseudomonas aeruginosa." Infection and Immunity 74, no. 2 (2006): 1121–29. http://dx.doi.org/10.1128/iai.74.2.1121-1129.2006.

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ABSTRACT The type III secretion system (TTSS) of Pseudomonas aeruginosa is induced in vivo upon contact with eukaryotic cells and in vitro by calcium depletion in culture medium. We have observed a previously identified protein, PsrA, necessary for full activation of TTSS gene expression in P. aeruginosa. Electrophoretic mobility shift assays showed that recombinant PsrA could bind to the exsCEBA promoter region. A mutant with a deletion in the psrA gene was constructed. Using transcriptional fusions, we demonstrated that PsrA is required for the full activation of transcription of the TTSS re

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16

Cohn, Megan, Rebecca S. Bart, Mikel Shybut, et al. "Xanthomonas axonopodis Virulence Is Promoted by a Transcription Activator-Like Effector–Mediated Induction of a SWEET Sugar Transporter in Cassava." Molecular Plant-Microbe Interactions® 27, no. 11 (2014): 1186–98. http://dx.doi.org/10.1094/mpmi-06-14-0161-r.

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The gene-for-gene concept has historically been applied to describe a specific resistance interaction wherein single genes from the host and the pathogen dictate the outcome. These interactions have been observed across the plant kingdom and all known plant microbial pathogens. In recent years, this concept has been extended to susceptibility phenotypes in the context of transcription activator-like (TAL) effectors that target SWEET sugar transporters. However, because this interaction has only been observed in rice, it was not clear whether the gene-for-gene susceptibility was unique to that

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17

Ma, H., P. Reyes-Gutierrez, and T. Pederson. "Visualization of repetitive DNA sequences in human chromosomes with transcription activator-like effectors." Proceedings of the National Academy of Sciences 110, no. 52 (2013): 21048–53. http://dx.doi.org/10.1073/pnas.1319097110.

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18

Wang, Zhao, Juan Li, Huang Huang, et al. "An Integrated Chip for the High-Throughput Synthesis of Transcription Activator-like Effectors." Angewandte Chemie 124, no. 34 (2012): 8633–36. http://dx.doi.org/10.1002/ange.201203597.

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19

Wang, Zhao, Juan Li, Huang Huang, et al. "An Integrated Chip for the High-Throughput Synthesis of Transcription Activator-like Effectors." Angewandte Chemie International Edition 51, no. 34 (2012): 8505–8. http://dx.doi.org/10.1002/anie.201203597.

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20

Lee, Dongseon, Woong-Hee Shin, and Chaok Seok. "Computational Modeling of the Binding Mode of Transcription Activator-Like Effectors to DNA." Biophysical Journal 102, no. 3 (2012): 72a. http://dx.doi.org/10.1016/j.bpj.2011.11.419.

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21

Rathi, Preeti, Sara Maurer, and Daniel Summerer. "Selective recognition of N 4-methylcytosine in DNA by engineered transcription-activator-like effectors." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1748 (2018): 20170078. http://dx.doi.org/10.1098/rstb.2017.0078.

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The epigenetic DNA nucleobases 5-methylcytosine (5mC) and N 4-methylcytosine (4mC) coexist in bacterial genomes and have important functions in host defence and transcription regulation. To better understand the individual biological roles of both methylated nucleobases, analytical strategies for distinguishing unmodified cytosine (C) from 4mC and 5mC are required. Transcription-activator-like effectors (TALEs) are programmable DNA-binding repeat proteins, which can be re-engineered for the direct detection of epigenetic nucleobases in user-defined DNA sequences. We here report the natural, cy

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22

Lyu, Pin, Luxi Wang, and Baisong Lu. "Virus-Like Particle Mediated CRISPR/Cas9 Delivery for Efficient and Safe Genome Editing." Life 10, no. 12 (2020): 366. http://dx.doi.org/10.3390/life10120366.

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The discovery of designer nucleases has made genome editing much more efficient than before. The designer nucleases have been widely used for mechanistic studies, animal model generation and gene therapy development. However, potential off-targets and host immune responses are issues still need to be addressed for in vivo uses, especially clinical applications. Short term expression of the designer nucleases is necessary to reduce both risks. Currently, various delivery methods are being developed for transient expression of designer nucleases including Zinc Finger Nuclease (ZNF), Transcriptio

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23

Read, Andrew C., Mathilde Hutin, Matthew J. Moscou, Fabio C. Rinaldi, and Adam J. Bogdanove. "Cloning of the Rice Xo1 Resistance Gene and Interaction of the Xo1 Protein with the Defense-Suppressing Xanthomonas Effector Tal2h." Molecular Plant-Microbe Interactions® 33, no. 10 (2020): 1189–95. http://dx.doi.org/10.1094/mpmi-05-20-0131-sc.

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The Xo1 locus in the heirloom rice variety Carolina Gold Select confers resistance to bacterial leaf streak and bacterial blight, caused by Xanthomonas oryzae pv. oryzicola and X. oryzae pv. oryzae, respectively. Resistance is triggered by pathogen-delivered transcription activator-like effectors (TALEs) independent of their ability to activate transcription and is suppressed by truncated variants called truncTALEs, common among Asian strains. By transformation of the susceptible variety Nipponbare, we show that one of 14 nucleotide-binding, leucine-rich repeat (NLR) protein genes at the locus

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24

Carlson, D. F., W. Tan, and S. C. Fahrenkrug. "328 VERSATILE TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASE (TALEN)-MEDIATED ENGINEERING OF OSSABAW MINIATURE SWINE." Reproduction, Fertility and Development 25, no. 1 (2013): 312. http://dx.doi.org/10.1071/rdv25n1ab328.

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Transcription activator-like effector nucleases (TALEN) are programmable nucleases that join the modular DNA-binding domain of transcription activator-like (TAL) effectors with FokI endonuclease. TALEN-induced double-strand breaks can be used for gene inactivation via repair by nonhomologous end joining (NHEJ) or to stimulate homologous recombination with a user-specified template to create custom-designed disease alleles. Transfection of multiple TALEN pairs targeting the same chromosome can also produce chromosomal rearrangements such as large inversions and deletions. As genetic modificatio

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25

Solera, Dafne, Fabio L. G. Arenghi, Tanja Woelk, Enrica Galli та Paola Barbieri. "TouR-Mediated Effector-Independent Growth Phase-Dependent Activation of the σ54 Ptou Promoter of Pseudomonas stutzeri OX1". Journal of Bacteriology 186, № 21 (2004): 7353–63. http://dx.doi.org/10.1128/jb.186.21.7353-7363.2004.

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ABSTRACT Transcription of the catabolic touABCDEF operon, encoding the toluene-o-xylene monooxygenase of Pseudomonas stutzeri OX1, is driven by the σ54-dependent Ptou promoter, whose activity is controlled by the phenol-responsive NtrC-like activator TouR. In this paper we describe for the first time a peculiar characteristic of this system, namely, that Ptou transcription is activated in a growth phase-dependent manner in the absence of genuine effectors of the cognate TouR regulator. This phenomenon, which we named gratuitous activation, was observed in the native strain P. stutzeri OX1, as

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26

Xu, Zhengyin, Sai Wang, Liang Liu, et al. "Genome Resource of a Hypervirulent Strain LN4 of Xanthomonas oryzae pv. oryzae Causing Bacterial Blight of Rice." Plant Disease 104, no. 11 (2020): 2764–67. http://dx.doi.org/10.1094/pdis-12-19-2724-a.

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Xanthomonas oryzae pv. oryzae is the causative agent of bacterial blight of rice and causes severe harvest loss and challenges to a stable food supply globally. In this study, a hypervirulent strain, LN4, compatible in rice varieties carrying Xa3, Xa4, xa13, and xa25 resistance genes, was used to generate DNA for nanopore sequencing. After assembly, the genome comprises a single chromosome of 5,012,583 bp, consisting of a total of 6,700 predicted coding sequences. Seventeen transcription activator-like effectors (TALEs) were encoded in the genome, of which two (Tal7 and Tal6c) were major TALEs

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27

Sheikh, Taha, Liyuan Zhang, Muhammad Zubair, et al. "The Type III Accessory Protein HrpE of Xanthomonas oryzae pv. oryzae Surpasses the Secretion Role, and Enhances Plant Resistance and Photosynthesis." Microorganisms 7, no. 11 (2019): 572. http://dx.doi.org/10.3390/microorganisms7110572.

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Many species of plant-pathogenic gram-negative bacteria deploy the type III (T3) secretion system to secrete virulence components, which are mostly characteristic of protein effectors targeting the cytosol of the plant cell following secretion. Xanthomonas oryzae pv. oryzae (Xoo), a rice pathogen causing bacterial blight disease, uses the T3 accessory protein HrpE to assemble the pilus pathway, which in turn secretes transcription activator-like (TAL) effectors. The hrpE gene can execute extensive physiological and pathological functions beyond effector secretion. As evidenced in this study, w

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Juillerat, Alexandre, Marine Beurdeley, Julien Valton, et al. "Exploring the transcription activator-like effectors scaffold versatility to expand the toolbox of designer nucleases." BMC Molecular Biology 15, no. 1 (2014): 13. http://dx.doi.org/10.1186/1471-2199-15-13.

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29

Eom, Joon-Seob, Dangping Luo, Genelou Atienza-Grande, et al. "Diagnostic kit for rice blight resistance." Nature Biotechnology 37, no. 11 (2019): 1372–79. http://dx.doi.org/10.1038/s41587-019-0268-y.

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Abstract Blight-resistant rice lines are the most effective solution for bacterial blight, caused by Xanthomonas oryzae pv. oryzae (Xoo). Key resistance mechanisms involve SWEET genes as susceptibility factors. Bacterial transcription activator-like (TAL) effectors bind to effector-binding elements (EBEs) in SWEET gene promoters and induce SWEET genes. EBE variants that cannot be recognized by TAL effectors abrogate induction, causing resistance. Here we describe a diagnostic kit to enable analysis of bacterial blight in the field and identification of suitable resistant lines. Specifically, w

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Carter, Morgan E., Sara C. D. Carpenter, Zoë E. Dubrow, et al. "A TAL effector-like protein of an endofungal bacterium increases the stress tolerance and alters the transcriptome of the host." Proceedings of the National Academy of Sciences 117, no. 29 (2020): 17122–29. http://dx.doi.org/10.1073/pnas.2003857117.

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Symbioses of bacteria with fungi have only recently been described and are poorly understood. In the symbiosis ofMycetohabitans(formerlyBurkholderia)rhizoxinicawith the fungusRhizopus microsporus, bacterial type III (T3) secretion is known to be essential. Proteins resembling T3-secreted transcription activator-like (TAL) effectors of plant pathogenic bacteria are encoded in the three sequencedMycetohabitansspp. genomes. TAL effectors nuclear-localize in plants, where they bind and activate genes important in disease. The Burkholderia TAL-like (Btl) proteins bind DNA but lack the N- and C-term

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31

Fahrenkrug, S. C., W. Tan, S. G. Lillico, et al. "337 NONMEIOTIC INTROGRESSION OF QUANTITATIVE TRAIT NUCLEOTIDES AND CORRECTION OF CONGENITAL MUTATIONS IN LIVESTOCK WITH TRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES." Reproduction, Fertility and Development 25, no. 1 (2013): 316. http://dx.doi.org/10.1071/rdv25n1ab337.

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Genetic enhancement of livestock productivity and welfare are major goals of breeding and genetics programs. However, the introgression of desirable alleles across breeds is slow and inaccurate. The development of gene editing technologies would provide the opportunity to accelerate the genetic improvement of a diversity of livestock breeds. Transcription activator-like effector nucleases (TALEN) are programmable nucleases that join the modular DNA binding domain of transcription activator-like (TAL) effectors with FokI endonuclease. We found that TALEN could be easily manufactured and that 64

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32

Song, Congfeng, and Bing Yang. "Mutagenesis of 18 Type III Effectors Reveals Virulence Function of XopZPXO99 in Xanthomonas oryzae pv. oryzae." Molecular Plant-Microbe Interactions® 23, no. 7 (2010): 893–902. http://dx.doi.org/10.1094/mpmi-23-7-0893.

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Xanthomonas oryzae pv. oryzae depends on a type III secretion system (T3SS) to translocate effectors into host cells for its ability to cause bacterial blight of rice. All type III (T3) effectors with known function in X. oryzae pv. oryzae belong to a family of transcription activator-like (TAL) effectors. However, other, non–TAL-related effector genes are present in the genome, although their role in virulence and their mode of action have yet to be elucidated. Here, we report the generation of mutants for 18 non-TAL T3 effector genes and the identification of one that contributes to the viru

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33

Uhde-Stone, Claudia, Joseph Huang, and Biao Lu. "A robust dual reporter system to visualize and quantify gene expression mediated by transcription activator-like effectors." Biological Procedures Online 14, no. 1 (2012): 8. http://dx.doi.org/10.1186/1480-9222-14-8.

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34

Li, Ping, Liyuan Zhang, Xuyan Mo, et al. "Rice aquaporin PIP1;3 and harpin Hpa1 of bacterial blight pathogen cooperate in a type III effector translocation." Journal of Experimental Botany 70, no. 12 (2019): 3057–73. http://dx.doi.org/10.1093/jxb/erz130.

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AbstractVarieties of Gram-negative bacterial pathogens infect their eukaryotic hosts by deploying the type III translocon to deliver effector proteins into the cytosol of eukaryotic cells in which effectors execute their pathological functions. The translocon is hypothetically assembled by bacterial translocators in association with the assumed receptors situated on eukaryotic plasma membranes. This hypothesis is partially verified in the present study with genetic, biochemical, and pathological evidence for the role of a rice aquaporin, plasma membrane intrinsic protein PIP1;3, in the cytosol

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35

Perez-Quintero, Alvaro L., and Boris Szurek. "A Decade Decoded: Spies and Hackers in the History of TAL Effectors Research." Annual Review of Phytopathology 57, no. 1 (2019): 459–81. http://dx.doi.org/10.1146/annurev-phyto-082718-100026.

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Transcription activator-like effectors (TALEs) from the genus Xanthomonas are proteins with the remarkable ability to directly bind the promoters of genes in the plant host to induce their expression, which often helps bacterial colonization. Metaphorically, TALEs act as spies that infiltrate the plant disguised as high-ranking civilians (transcription factors) to trick the plant into activating weak points that allow an invasion. Current knowledge of how TALEs operate allows researchers to predict their activity (counterespionage) and exploit their function, engineering them to do our bidding

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36

Fink, Kyle D., Peter Deng, Josh Gutierrez, et al. "Allele-Specific Reduction of the Mutant Huntingtin Allele Using Transcription Activator-Like Effectors in Human Huntington's Disease Fibroblasts." Cell Transplantation 25, no. 4 (2016): 677–86. http://dx.doi.org/10.3727/096368916x690863.

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37

Lee, Ju-Hoon, Hakdong Shin, Hye-Jee Park, Sangryeol Ryu, and Sang-Wook Han. "Draft genome sequence of Xanthomonas axonopodis pv. glycines 8ra possessing transcription activator-like effectors used for genetic engineering." Journal of Biotechnology 179 (June 2014): 15–16. http://dx.doi.org/10.1016/j.jbiotec.2014.03.009.

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38

Yang, Feng-Juan, Li-Li Cheng, Ling Zhang, et al. "Y4lO of Rhizobium sp. Strain NGR234 Is a Symbiotic Determinant Required for Symbiosome Differentiation." Journal of Bacteriology 191, no. 3 (2008): 735–46. http://dx.doi.org/10.1128/jb.01404-08.

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ABSTRACT Type 3 (T3) effector proteins, secreted by nitrogen-fixing rhizobia with a bacterial T3 secretion system, affect the nodulation of certain host legumes. The open reading frame y4lO of Rhizobium sp. strain NGR234 encodes a protein with sequence similarities to T3 effectors from pathogenic bacteria (the YopJ effector family). Transcription studies showed that the promoter activity of y4lO depended on the transcriptional activator TtsI. Recombinant Y4lO protein expressed in Escherichia coli did not acetylate two representative mitogen-activated protein kinase kinases (human MKK6 and MKK1

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Kremer, Frederico Schmitt, Amanda Munari Guimarães, Christian Domingues Sanchez, and Luciano da Silva Pinto. "TargeTALE: A Web Resource to Identify TALEs in Xanthomonas Genomes and Their Respective Targets." Molecular Plant-Microbe Interactions® 32, no. 12 (2019): 1577–80. http://dx.doi.org/10.1094/mpmi-08-19-0227-a.

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The Xanthomonas genus, comprises more than 30 species of gram-negative bacteria, most of which are pathogens of plants with high economic value, such as rice, common bean, and maize. Transcription activator-like effectors (TALEs), which act by regulating the host gene expression, are some of the major virulence factors of these bacteria. We present a novel tool to identify TALE genes in the genome of Xanthomonas strains and their respective targets. The analysis of the results obtained by TargeTALE in a proof-of-concept validation demonstrate that, at optimum setting, approximately 93% of the

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40

Geel, T. M., M. H. J. Ruiters, R. H. Cool, et al. "The past and presence of gene targeting: from chemicals and DNA via proteins to RNA." Philosophical Transactions of the Royal Society B: Biological Sciences 373, no. 1748 (2018): 20170077. http://dx.doi.org/10.1098/rstb.2017.0077.

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The ability to target DNA specifically at any given position within the genome allows many intriguing possibilities and has inspired scientists for decades. Early gene-targeting efforts exploited chemicals or DNA oligonucleotides to interfere with the DNA at a given location in order to inactivate a gene or to correct mutations. We here describe an example towards correcting a genetic mutation underlying Pompe's disease using a nucleotide-fused nuclease (TFO-MunI). In addition to the promise of gene correction, scientists soon realized that genes could be inactivated or even re-activated witho

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41

Pérez-Quintero, Alvaro L., Léo Lamy, Carlos A. Zarate, et al. "daTALbase: A Database for Genomic and Transcriptomic Data Related to TAL Effectors." Molecular Plant-Microbe Interactions® 31, no. 4 (2018): 471–80. http://dx.doi.org/10.1094/mpmi-06-17-0153-fi.

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Transcription activator-like effectors (TALEs) are proteins found in the genus Xanthomonas of phytopathogenic bacteria. These proteins enter the nucleus of cells in the host plant and can induce the expression of susceptibility genes (S genes), triggering disease. TALEs bind the promoter region of S genes following a specific code, which allows the prediction of binding sites based on TALEs amino acid sequences. New candidate S genes can then be discovered by finding the intersection between genes induced in the presence of TALEs and genes containing predicted effector binding elements. By con

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42

Pappas, Christopher J., and Mathieu Picardeau. "Control of Gene Expression in Leptospira spp. by Transcription Activator-Like Effectors Demonstrates a Potential Role for LigA and LigB in Leptospira interrogans Virulence." Applied and Environmental Microbiology 81, no. 22 (2015): 7888–92. http://dx.doi.org/10.1128/aem.02202-15.

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ABSTRACTLeptospirosis is a zoonotic disease that affects ∼1 million people annually, with a mortality rate of >10%. Currently, there is an absence of effective genetic manipulation tools for targeted mutagenesis in pathogenic leptospires. Transcription activator-like effectors (TALEs) are a recently described group of repressors that modify transcriptional activity in prokaryotic and eukaryotic cells by directly binding to a targeted sequence within the host genome. To determine the applicability of TALEs withinLeptospiraspp., two TALE constructs were designed. First, a constitutively expre

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Tiffon, Camille, Julie Giraud, Silvia Elena Molina-Castro, et al. "TAZ Controls Helicobacter pylori-Induced Epithelial–Mesenchymal Transition and Cancer Stem Cell-Like Invasive and Tumorigenic Properties." Cells 9, no. 6 (2020): 1462. http://dx.doi.org/10.3390/cells9061462.

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Helicobacter pylori infection, the main risk factor for gastric cancer (GC), leads to an epithelial–mesenchymal transition (EMT) of gastric epithelium contributing to gastric cancer stem cell (CSC) emergence. The Hippo pathway effectors yes-associated protein (YAP) and transcriptional co-activator with PDZ binding motif (TAZ) control cancer initiation and progression in many cancers including GC. Here, we investigated the role of TAZ in the early steps of H. pylori-mediated gastric carcinogenesis. TAZ implication in EMT, invasion, and CSC-related tumorigenic properties were evaluated in three

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Gersbach, Charles A., and Pablo Perez-Pinera. "Activating human genes with zinc finger proteins, transcription activator-like effectors and CRISPR/Cas9 for gene therapy and regenerative medicine." Expert Opinion on Therapeutic Targets 18, no. 8 (2014): 835–39. http://dx.doi.org/10.1517/14728222.2014.913572.

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Fang, Yongxing, Wladislaw Stroukov, Toni Cathomen, and Claudio Mussolino. "Chimerization Enables Gene Synthesis and Lentiviral Delivery of Customizable TALE-Based Effectors." International Journal of Molecular Sciences 21, no. 3 (2020): 795. http://dx.doi.org/10.3390/ijms21030795.

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Designer effectors based on the DNA binding domain (DBD) of Xanthomonas transcription activator-like effectors (TALEs) are powerful sequence-specific tools with an excellent reputation for their specificity in editing the genome, transcriptome, and more recently the epigenome in multiple cellular systems. However, the repetitive structure of the TALE arrays composing the DBD impedes their generation as gene synthesis product and prevents the delivery of TALE-based genes using lentiviral vectors (LVs), a widely used system for human gene therapy. To overcome these limitations, we aimed at chime

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Omelina, E. S., and A. V. Pindyurin. "Optogenetic regulation of endogenous gene transcription in mammals." Vavilov Journal of Genetics and Breeding 23, no. 2 (2019): 219–25. http://dx.doi.org/10.18699/vj19.485.

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Despite the rapid development of approaches aimed to precisely control transcription of exogenous genes in time and space, design of systems providing similar tight regulation of endogenous gene expression is much more challenging. However, finding ways to control the activity of endogenous genes is absolutely necessary for further progress in safe and effective gene therapies and regenerative medicine. In addition, such systems are of particular interest for genetics, molecular and cell biology. An ideal system should ensure tunable and reversible spatio-temporal control over transcriptional

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Bochtler, Matthias. "Structural basis of the TAL effector–DNA interaction." Biological Chemistry 393, no. 10 (2012): 1055–66. http://dx.doi.org/10.1515/hsz-2012-0164.

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Abstract Phytopathogen transcription activator-like effectors (TALEs) bind DNA in a sequence specific manner in order to manipulate host transcription. TALE specificity correlates with repeat variable diresidues in otherwise highly stereotypical 34–35mer repeats. Recently, the crystal structures of two TALE DNA-binding domains have illustrated the molecular basis of the TALE cipher. The structures show that the TALE repeats form a right-handed superhelix that is wound around largely undistorted B-DNA to match its helical parameters. Surprisingly, repeat variable residue 1 is not in contact wit

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Niu, Qiuhong, Haoying Zheng, Lin Zhang, et al. "Knockout of the adp gene related with colonization in B acillus nematocida B 16 using customized transcription activator‐like effectors nucleases." Microbial Biotechnology 8, no. 4 (2015): 681–92. http://dx.doi.org/10.1111/1751-7915.12282.

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Carpenter, Sara C. D., Lawan Kladsuwan, Sang-Wook Han, Sutruedee Prathuangwong, and Adam J. Bogdanove. "Complete Genome Sequences of Xanthomonas axonopodis pv. glycines Isolates from the United States and Thailand Reveal Conserved Transcription Activator-Like Effectors." Genome Biology and Evolution 11, no. 5 (2019): 1380–84. http://dx.doi.org/10.1093/gbe/evz085.

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Oliva, Ricardo, Chonghui Ji, Genelou Atienza-Grande, et al. "Broad-spectrum resistance to bacterial blight in rice using genome editing." Nature Biotechnology 37, no. 11 (2019): 1344–50. http://dx.doi.org/10.1038/s41587-019-0267-z.

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Abstract Bacterial blight of rice is an important disease in Asia and Africa. The pathogen, Xanthomonas oryzae pv. oryzae (Xoo), secretes one or more of six known transcription-activator-like effectors (TALes) that bind specific promoter sequences and induce, at minimum, one of the three host sucrose transporter genes SWEET11, SWEET13 and SWEET14, the expression of which is required for disease susceptibility. We used CRISPR–Cas9-mediated genome editing to introduce mutations in all three SWEET gene promoters. Editing was further informed by sequence analyses of TALe genes in 63 Xoo strains, w

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