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Dissertations / Theses on the topic 'Transcription regulation model'

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Published: 3 June 2025
Last updated: 31 July 2025

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1

Dunham, Lee. "Dynamic regulation of growth hormone gene transcription." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/dynamic-regulation-of-growth-hormone-gene-transcription(62354b9b-c755-43b6-a3f0-d108c32232c9).html.

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Many genes demonstrate highly dynamic pulsatile expression, with characteristic bursts of activity. Dynamic expression of the human prolactin (hPrl) gene in pituitary cells has previously been investigated identifying key temporal characteristics, influenced by the process of chromatin remodelling. Earlier work on the related pituitary human growth hormone (hGH) proximal promoter (-496/+1bp) indicated that it displayed similar dynamic behaviour. The human GH gene contains an extensive long-distance regulatory sequence, including a locus control region (-14/-32kbp) that has been shown to regula
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2

Amiott, Elizabeth Anne. "A model for the carbon source regulation of yeast mitochondrial transcription /." Connect to full text via ProQuest. IP filtered, 2005.

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Thesis (Ph.D. in Molecular Biology) -- University of Colorado, 2005.<br>Typescript. Includes bibliographical references (leaves 100-113). Free to UCDHSC affiliates. Online version available via ProQuest Digital Dissertations;
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3

Lloréns, Rico Verónica 1989. "Integrative understanding of transcription in a minimal cell model." Doctoral thesis, Universitat Pompeu Fabra, 2016. http://hdl.handle.net/10803/459003.

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One of the major challenges of biology is to understand how entire cells or organisms behave in homeostasis and in response to perturbations. Whole-cell modeling promotes this understanding by integrating different cellular processes in a single model that is able to predict emergent cellular behaviors. In this thesis, we have developed the first whole-cell model of the genome-reduced bacterium Mycoplasma pneumoniae, which encodes for less than 700 protein-coding genes. This model follows the structure of the previously described model in Mycoplasma genitalium. However, the lack of comprehensi
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4

Ilsley, Garth Robert. "A statistical model relating transcription factor concentrations to positional information in the early Drosophila embryo." Thesis, University of Cambridge, 2010. https://www.repository.cam.ac.uk/handle/1810/236115.

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The idea of morphogen gradients encoding positional information for a developing organism has long been discussed in the field of developmental biology, but only recently have quantitative models been proposed that relate measured transcription factor concentrations to enhancer activity. However, successful models are typically computationally time-consuming, thus limiting full exploration and interpretation of the data. This thesis addresses these problems using standard statistical techniques applied to a comprehensive data set with the even skipped (eve) locus as a test case. The first part
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5

Thompson, Dorothea Kathleen. "Regulation of gene transcription in the archaeon haloferax volcanii using the heat shock response as a model system /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487948807587033.

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6

Andersson, Patrik. "Functional role of a constitutively active dioxin/Ah receptor in a transgenic mouse model /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-469-0/.

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7

Ozolins, Terence Robert Stanislavs. "Regulation of the transcription factor activator protein-1 (AP-1) in the whole rat embryo culture model in response to oxidative stress." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape11/PQDD_0015/NQ44545.pdf.

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8

Kuo, Yen-Ping. "In vivo characterization of archaeal transcription termination signals, and, characterization of a Haloferax volcanii heat shock gene: A model for gene regulation /." The Ohio State University, 1997. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487945015616366.

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9

Kennedy, Brian Alexander. "Developing the Cis-Regulatory Association Model (CRAM) to Identify Combinations of Transcription Factors in ChIP-Seq Data." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1291138540.

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10

Zonta, Eleonora. "Implications of RNA helicases ddx5 (p68) and ddx17 (p72) in alternative splicing regulation and mRNA export in a mammary tumor model." Paris 7, 2012. http://www.theses.fr/2012PA077104.

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Les ARN hélicases ddx5 (p68) et ddx17 (p72) sont deux protéines multifonctionnelles très similaires connues pour jouer un rôle dans la transcription comme co-régulateurs de divers facteurs de transcription, dans la maturation des miARNs et des mARNs, en particulier dans l'épissage. Il a été également montré que ces deux hélicases sont impliquées dans le développement et dans différents types de cancers. Afin de mieux comprendre les mécanismes par lesquels ddx5 et ddx17 contrôlent l'expression génique, j'ai dans un premier temps examiné le rôle de ddx5 dans la régulation de c-fos, un gène cible
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11

Schulthess, Pascal. "Thermodynamic modeling explains the regulation of CYP1A1 expression in the liver." Doctoral thesis, Humboldt-Universität zu Berlin, Lebenswissenschaftliche Fakultät, 2016. http://dx.doi.org/10.18452/17454.

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Die vorliegende Studie präsentiert eine Analyse der Integration der AhR und Wnt/beta-catenin Signalwege in den CYP1A1 Promotor sowie den regulatorischen Einfluss der Promotorlogik auf die Genexpression. Experimentell wurde diese Analyse mithilfe 29 mutagener Reporterkonstrukte des humanen CYP1A1 Promotors durchgeführt. Ein mathematisches Modell, welches eine Repräsentation des Crosstalks der Signaltransduktionswege mit einer statistisch mechanischen Beschreibung der kombinatorischen Promotorbelegung kombiniert, komplementierte den experimentellen Ansatz. Unter zusätzlicher Zuhilfenahme von gut
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12

Tokola, H. (Heikki). "Mechanical stretch and peptide growth factors in the regulation of the hypertrophic response of cardiomyocytes:ANP and BNP as model genes." Doctoral thesis, Oulun yliopisto, 2015. http://urn.fi/urn:isbn:9789526210001.

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Abstract Cardiac hypertrophy is the primary adaptive mechanism of the heart to increased workload, though when advanced, it becomes a leading predictor for heart failure and sudden death. The growth stimulus elicited by a hemodynamic load is attributable to a combination of mechanical and neurohumoral factors, but the precise roles of individual growth promoting components are still unclear. This study utilized atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) as model genes with which to investigate the involvement and mechanisms of mechanical stress and peptide growth fac
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13

Meseguer, Donlo Alberto 1993. "Methods to model and assess protein-DNA and protein-protein interactions in the context of gene regulation." Doctoral thesis, Universitat Pompeu Fabra, 2021. http://hdl.handle.net/10803/672355.

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Las células de nuestro cuerpo son capaces de tener comportamientos y morfologías completamente diferentes, pese a contener el mismo material genético. Entre los mecanismos que permiten esta diversidad encontramos los factores de transcripción (FTs). Los FTs son proteínas capaces de unirse a secuencias específicas de ADN en nuestro genoma y modular la expresión de los genes cercanos. La elección de que genes son regulados por cada FT viene dada por su especificidad y afinidad por ciertas secuencias de ADN. Por otro lado, el efecto sobre la expresión génica, ya sea su incremento o su disminución
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14

Thomas, David John. "Transcription regulation : models for combinatorial regulation and functional specificity." Thesis, University of Sussex, 2014. http://sro.sussex.ac.uk/id/eprint/48754/.

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Gene regulation id controlled by transcription factor proteins that bind to specific DNA sequences, known as transcription factor binding sites (TFBSs). Combinations of transcription factors working, co-operatively in cis-regulatory modules (CRMs), play a role in regulating gene expression. Current computational methods for TFBS prediction cannot distinguish between functional and non-functional sites, and predict very large numbers of false positives. The thesis focuses on the development of a novel computational model, based on artificial neural networks (ANNs), for the identification of fun
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15

Reid, John Edward. "Probabilistic models of transcriptional regulation." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648864.

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16

Bornelöv, Susanne. "Rule-based Models of Transcriptional Regulation and Complex Diseases : Applications and Development." Doctoral thesis, Uppsala universitet, Beräknings- och systembiologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230159.

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As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. Furthermore, gene activation and splicing seem to be governed by a complex machinery of histone modification (HM), transcription factor (TF), and DNA sequence signals. This thesis aimed to apply and develop multivariate machine learning methods for use on such biological problems. Monte Carlo feature selection was combined with rule-
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17

Cruickshank, Mark. "Analysis of CR2/CD21 transcriptional regulation by chromatin structural variation and notch activity in human cell models." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2007. http://theses.library.uwa.edu.au/adt-WU2007.0115.

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[Truncated abstract] Human complement receptor 2 (CR2/CD21) is a cell surface glycoprotein detected on specific cells involved in immunity, which binds complement C3 cleavage fragments, cellular ligands IFN-? and CD23 as well as the EBV coat protein, gp350/220. During the early stages of B-cell development CR2/CD21 is silenced. Expression is initiated on immature B-cells escaping negative selection. During peripheral maturation CR2/CD21 is up-regulated with B-cell sub-populations showing distinctive surface levels (comparatively low, intermediate or high). CR2/CD21 is silenced upon terminal pl
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18

Hockings, Chi-Fan Ku. "A Molecular Model For Transcriptional Regulation of BRCA-1 Expression." Diss., Tucson, Arizona : University of Arizona, 2005. http://etd.library.arizona.edu/etd/GetFileServlet?file=file:///data1/pdf/etd/azu%5Fetd%5F1352%5F1%5Fm.pdf&type=application/pdf.

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19

Lim, Chee Yee. "Understanding transcriptional regulation through computational analysis of single-cell transcriptomics." Thesis, University of Cambridge, 2017. https://www.repository.cam.ac.uk/handle/1810/267786.

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Gene expression is tightly regulated by complex transcriptional regulatory mechanisms to achieve specific expression patterns, which are essential to facilitate important biological processes such as embryonic development. Dysregulation of gene expression can lead to diseases such as cancers. A better understanding of the transcriptional regulation will therefore not only advance the understanding of fundamental biological processes, but also provide mechanistic insights into diseases. The earlier versions of high-throughput expression profiling techniques were limited to measuring average gen
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20

Gustavo, Soares da Fonseca Paulo. "Computational methods for the identification of transcriptional regulation modules." Universidade Federal de Pernambuco, 2008. https://repositorio.ufpe.br/handle/123456789/1452.

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Made available in DSpace on 2014-06-12T15:50:15Z (GMT). No. of bitstreams: 2 arquivo1959_1.pdf: 2352925 bytes, checksum: 90760b286db4ed0dcc12ae48554413a9 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2008<br>Coordenação de Aperfeiçoamento de Pessoal de Nível Superior<br>Estudos recentes têm demonstrado que as redes biológicas apresentam características nãoaleatórias, dentre as quais destacamos a arquitetura modular. Neste trabalho, estamos interessados na organização modular das redes de regulação transcricional (RRT), que modelizam a
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21

Preiss, Thomas. "Cytochrome c oxidase : a model system for post-transcriptional gene regulation." Thesis, University of Newcastle Upon Tyne, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281705.

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22

ASTONE, GIUSEPPINA ILIANA. "Biological and transcriptional regulation of the culprit in PDX lymphoma model." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/1008570.

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The anaplastic large cell lymphoma (ALCL), a subtype of peripheral T-cell lymphoma (PTCL), is a lymphoid malignancy characterized by a “hallmark cells” and elevated expression of CD30. Anaplastic lymphoma kinase–positive (ALK+) carry ALK fusions, more often the NPM-ALK t(2;5) translocation, while about 40% of all ALCLs are negative (ALK-). ALK chimeras promote cell survival and tumorigenesis by constitutively activating multiple cell signaling pathways, including the STAT3 pathway. STAT3 is a member of family Signal Transducers and Activators of Transcription (STATs), and its chronic activatio
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23

Testa, Damien. "Contrôler la plasticité du cortex cérébral adulte à travers l'action non-autonome de l'homéoprotéine Otx2 A Mouse Model for Conditional Secretion of Specific Single-Chain Antibodies Provides Genetic Evidence for Regulation of Cortical Plasticity by a Non-cell Autonomous Homeoprotein Transcription Factor Non-cell Autonomous OTX2 Homeoprotein Regulates Visual Cortex Plasticity Through Gadd45b/g." Thesis, Sorbonne université, 2018. http://www.theses.fr/2018SORUS234.

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Durant le développement postnatal, l'homéoprotéine Otx2 est préférentiellement internalisée par les interneurones parvalbumine (PV) du cortex visuel et régule la période critique de plasticité de dominance oculaire. La spécificité d'internalisation d'Otx2 est médié par la chondroïtine sulfate de type E (CS-E) qui est un composant de la matrice extracellulaire enrichie en glycosaminoglycanes condensé autour des cellules PV durant la période critique. L'apport constant d'Otx2 chez l'adulte est nécessaire au maintien de l'état non-plastique du cortex. Une réouverture de plasticité est possible en
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24

Williamson, Beth. "Determinants of transcriptional regulation of transport and oxidative processes in human model systems." Thesis, University of Liverpool, 2013. http://livrepository.liverpool.ac.uk/15053/.

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Initial predictions of drug response and drug-drug interactions (DDIs) are made following high-throughput in vitro screening. Such assays are indispensible in the pharmaceutical industry to determine the metabolism, transport and pharmacokinetics of new chemical entities. However, they often fail when extrapolated to in vivo response due to unsuitable pharmacokinetic or pharmacodynamic prediction. The primary aim of this thesis was to investigate and understand the differences in the expression profiles of drug disposition genes, between transformed hepatic cell lines and primary human hepatoc
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25

Bewry, Nadine N. "STAT3 Contributes to Resistance Towards BCR-ABL Inhibitors in a Bone Marrow Microenvironment Model of Drug Resistance in Chronic Myeloid Leukemia Cells." [Tampa, Fla] : University of South Florida, 2009. http://purl.fcla.edu/usf/dc/et/SFE0002892.

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26

Keightley, Angela M. "Transcriptional regulation ofvon Willebrand factor in endothelial cells, a model of genotype-environment interaction." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/NQ54420.pdf.

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27

Simeoni, F. "TRANSCRIPTIONAL REGULATION OF STOMATAL RESPONSES TO STRESS: FROM A MODEL SYSTEM TO VITIS VINIFERA." Doctoral thesis, Università degli Studi di Milano, 2015. http://hdl.handle.net/2434/252354.

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Grapevine (Vitis spp.) is a fruit crop traditionally subjected to moderate or severe water stress. Vitis species adapt well to drought conditions due to good osmotic adjustment, but the strength and timing of these responses varies between different cultivars and major differences in water stress tolerance can be found among species or hybrids from the Vitis genus. These genotype-related variations involve different aspects of the physiology of the plant, including differences in stomatal conductance (gs, mmol H2O m-2s-1). Stomatal conductance is a key trait in grapevine, as it directly deter
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28

Kang, Yeon-Joo. "Transcriptional regulation of prostaglandin H synthase (PGHS)-2 gene in a macrophage model of inflammation." Diss., Connect to online resource - MSU authorized users, 2006.

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29

Zacher, Benedikt [Verfasser], and Patrick [Akademischer Betreuer] Cramer. "Genomic data integration with hidden Markov models to understand transcription regulation / Benedikt Zacher. Betreuer: Patrick Cramer." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2016. http://d-nb.info/1102897191/34.

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30

ROSSI, SIMONA. "C9orf72 repeat expansion alters post-transcriptional gene regulation in a cellular model of amyotrophic lateral sclerosis." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/202111.

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A non-coding GGGGCC (G4C2) repeat expansion in the C9orf72 gene is the major genetic determinant of Amyotrophic Lateral Sclerosis (ALS), a late‐onset neurodegenerative disorder characterized by the selective loss of upper and lower motor neurons (Cozzolino et al., 2012). A common feature of non-coding repeat expansion disorders is the accumulation of RNA repeats as RNA foci in the nucleus and/or cytoplasm of affected cells. These RNA foci can be toxic by sequestering RNA-binding proteins, whose decreased availability may then affect various steps of post-transcriptional gene regulation, such a
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31

Al, Zamal Faiyaz. "Relating the expression-based and sequence-based estimates of regulation in the gap gene system of Drosophila melanogaster." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112321.

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Quantitative analysis of Drosophila melanogaster gap gene expression data reveals valuable information about the nature and strengths of interactions in the gap gene network. We first explore different models for fitting the spatiotemporal gene expression data of Drosophila gap gene system and validate our results by computational analysis and comparison with the existing literature. A fundamental problem in systems biology is to associate these results with the inherent cause of gene regulation, namely the binding of the transcription factors (TF) to their respective binding sites. In order t
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32

Zaherddine, Jana. "Stochastic models of protein production in bacterial cells : analysis of regulation mechanisms for transcription and translation phases." Electronic Thesis or Diss., Sorbonne université, 2023. http://www.theses.fr/2023SORUS576.

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Le processus de production des protéines est composé de deux étapes. La première étape consiste à produire des molécules d’ARN, par des macromolécules appelées polymérases, à partir des gènes d'ADN. Cette étape est connue par la phase de transcription. La deuxième étape, appelée traduction, implique la synthèse des protéines à partir de molécules d'ARN messager (ARNm) en utilisant des macromolécules appelées ribosomes. La production de protéines est un processus central qui consomme une partie significative de ses ressources. Comprendre les mécanismes et la régulation de l'expression des gènes
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Trocme, Caryn. "Role des sequences cre et tre dans la regulation de l'expression du gene codant pour la tyrosine hydroxylase de rat ; etudes ex vivo et par transgenese." Paris 11, 1997. http://www.theses.fr/1997PA11T026.

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34

Oberstrass, Florian Christophe. "Novel modes of protein-RNA recognition in post-transcriptional gene regulation studied by NMR spectroscopy." kostenfrei kostenfrei, 2007. http://e-collection.ethbib.ethz.ch/view/eth:30123.

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Drost, Derek R. "The genetic regulation of gene expression, transcriptional networks, and leaf development in the perennial model plant Populus." [Gainesville, Fla.] : University of Florida, 2009. http://purl.fcla.edu/fcla/etd/UFE0041074.

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Buttiglione, V. "THE ROLE OF MIR-340 IN POST-TRANSCRIPTIONAL REGULATION OF THE UPA-SYSTEM IN BREAST CANCER." Doctoral thesis, Università degli Studi di Milano, 2016. http://hdl.handle.net/2434/365720.

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The urokinase-type plasminogen activator system (uPA-system), whose main components are the serine protease uPA (PLAU), the cell surface receptor uPAR (PLAUR) and the uPA inhibitor PAI-1 (SERPINE1), has been extensively studied for its involvement in cancer pathogenesis. Specifically, nowadays the components of the uPA-system are well-characterised determinants for the prognosis of breast cancer. The regulation of the gene expression of the uPA-system components is very complex and depends on a plethora of stimuli acting both at transcriptional and post-transcriptional level. The uPA-system co
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Meca-Cortés, Oscar. "Regulation of self-renewal in colorectal cancer cell models." Doctoral thesis, Universitat de Barcelona, 2014. http://hdl.handle.net/10803/285598.

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The transcription factor SOX2 is a key determinant of stem cell properties, also involved in the initiation, maintenance and progression of several human cancers. By studying the in vitro phenotypic consequences of SOX2 overexpression and knock down in a panel of cell lines, we have found that high levels of SOX2 leads to DNA damage and accumulation of reactive oxygen species, accompanied with cell cycle arrest and apoptosis in colorectal cancer cell lines, SW620 and SW480. We have also found that knock down of SOX2 in the metastatic colorectal cancer cell line SW620, led to
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Enroth, Stefan. "The Nucleosome as a Signal Carrying Unit : From Experimental Data to Combinatorial Models of Transcriptional Control." Doctoral thesis, Uppsala universitet, Centrum för bioinformatik, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129181.

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The human genome consists of over 3 billion nucleotides and would be around 2 meters long if uncoiled and laid out. Each human somatic cell contains all this in their nucleus which is only around 5 µm across. This extreme compaction is largely achieved by wrapping the DNA around a histone octamer, the nucleosome. Still, the DNA is accessible to the transcriptional machinery and this regulation is highly dynamic and change rapidly with, e.g. exposure to drugs. The individual histone proteins can carry specific modifications such as methylations and acetylations. These modifications are a major
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Fleming, Joseph. "Genome-wide Integrative Analysis of Transcription Factor Occupancy and Gene Regulation in Models of Human Cancer and Cellular Differentiation." Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10620.

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Few transcription factors (TFs) have been studied in the context of an integrative analysis incorporating genomic datasets from diverse genome regulatory mechanisms. Such an analysis allows the testing of specific regulatory associations in an unbiased and comprehensive manner. The promoter binding TF complex NF-Y regulates a diverse set of constitutive, inducible, developmental, oncogenic and tissue-specific genes. Using cancer models, ChIP-Seq, shRNA, and genomics, I have undertaken a genome-wide study of NF-Y. NF-Y binds to not only promoters but also extensively to enhancers, select classe
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40

Le, Treut Guillaume. "Models of chromosome architecture and connection with the regulation of genetic expression." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLS411/document.

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Plusieurs indices suggèrent que le repliement du chromosome et la régulation de l’expression génétique sont étroitement liés. Par exemple, la co-expression d’un grand nombre de gènes est favorisée par leur rapprochement dans l’espace cellulaire. En outre, le repliement du chromosome permet de faire émerger des structures fonctionnelles. Celles-ci peuvent être des amas condensés et fibrillaires, interdisant l’accès à l’ADN, ou au contraire des configurations plus ouvertes de l’ADN avec quelques amas globulaires, comme c’est le cas avec les usines de transcription. Bien que dissemblables au prem
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41

BARBON, Elena. "Development of cellular and animal models of coagulation factors deficiencies for the assessment of innovative therapeutic approaches acting on transcriptional and post-transcriptional regulation." Doctoral thesis, Università degli studi di Ferrara, 2015. http://hdl.handle.net/11392/2388976.

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In the last decades, enormous efforts have been pushed toward the development of molecular therapeutic approaches for human genetic diseases, and the research all over the world has obtained remarkable achievements, especially in gene therapy field. Notwithstanding, the intense research also led to potential therapeutic strategies based on the correction of the specific disease-causing defects, which might circumvent some limitations of gene replacement therapy. These approaches are of great interest for patients with coagulation deficiencies, since they would benefit even from small inc
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Fouquier, d'Herouel Aymeric. "Statistical models of TF/DNA interaction." Licentiate thesis, Stockholm : Numerisk analys och datalogi, Numerical Analysis and Computer Science, Kungliga Tekniska högskolan, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4633.

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43

Bowles, Kathryn R. "Characterisation of huntingtin localisation and transcriptional regulation in response to growth factor stimulation in an immortalised cell model of Huntington's Disease." Thesis, Cardiff University, 2013. http://orca.cf.ac.uk/56396/.

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Disease (HD) is an autosomal dominant neurodegenerative disease caused by a CAG expansion on the HD gene on chromosome 4, which gives rise to an expanded polyglutamine (polyQ) tract in the huntingtin protein. HD is characterised primarily by motor abnormalities, but is also commonly associated with cognitive impairments and psychiatric disturbances. Huntingtin (HTT) dynamically shuttles between subcellular compartments, however the mutant huntingtin protein (mHTT) is mislocalised to cell nuclei, where it may interfere with nuclear functions, such as transcription. The phosphorylation of HTT ha
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Jiang, Bo. "Partition Models for Variable Selection and Interaction Detection." Thesis, Harvard University, 2013. http://dissertations.umi.com/gsas.harvard:10911.

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Variable selection methods play important roles in modeling high-dimensional data and are key to data-driven scientific discoveries. In this thesis, we consider the problem of variable selection with interaction detection. Instead of building a predictive model of the response given combinations of predictors, we start by modeling the conditional distribution of predictors given partitions based on responses. We use this inverse modeling perspective as motivation to propose a stepwise procedure for effectively detecting interaction with few assumptions on parametric form. The proposed procedur
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Stigliani, Arnaud. "Modélisation de la liaison à l'ADN et des mécanismes d'action de facteurs de transcription floraux Building Transcription Factor Binding Site Models to Understand Gene Regulation in Plants JASPAR 2018: Update of the open-access database of transcription factor binding profiles and its web framework." Thesis, Université Grenoble Alpes (ComUE), 2019. https://thares.univ-grenoble-alpes.fr/2019GREAV032.pdf.

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Chez les angiospermes, la floraison est un processus qui prend part en plusieurs étapes. Le méristème caulinaire, un réservoir de cellule souche d’où émergent la totalité des organes aériens de la plante, va d’abord se différencier en méristème d’inflorescence. Des méristèmes floraux vont alors émerger des flancs du méristème d’inflorescence pour donner naissance aux différents organes qui composent la fleur : les pétales, les sépales, les étamines et le carpelle. Chacune de ces phases est régulée avec finesse par des facteurs de transcription, une famille de protéines se liant à l’ADN pour in
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46

Prata, Guilherme Nery. "Um modelo estocástico para a transcrição do gene even-skipped de Drosophila melanogaster." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/76/76131/tde-04042013-105849/.

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Nesta tese desenvolvemos um modelo estocástico para a transcrição do gene even-skipped de Drosophila melanogaster no qual a variável estocástica é o número de moléculas de mRNA transcritas. Nesse modelo, consideramos um gene com dois níveis de ativação sendo regulado externamente. As probabilidades de se encontrar o gene ligado ou desligado e com determinado número de moléculas de mRNA transcritas obedecem equações lineares dadas por processos markovianos de nascimento-e-morte (taxas de produção e degradação) e termos de chaveamento entre os níveis cujas dependências temporais são dadas por fu
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47

Sekula, Sylwia. "Inhibition of c-Jun/ATF2 phosphorylation,Trans-repression of c-Jun/c-Fos:Two modes of regulation of the transcription factorAP-1 activity by Glucocorticoid Receptor." [S.l. : s.n.], 2007. http://digbib.ubka.uni-karlsruhe.de/volltexte/1000007309.

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Werner, Jeannette [Verfasser], Roland [Akademischer Betreuer] Lauster, Roland [Gutachter] Lauster, Manfred [Gutachter] Gossen, and Vera [Gutachter] Meyer. "Analysis of different modes of TAL effector-mediated transcriptional regulation / Jeannette Werner ; Gutachter: Roland Lauster, Manfred Gossen, Vera Meyer ; Betreuer: Roland Lauster." Berlin : Technische Universität Berlin, 2016. http://d-nb.info/1156012872/34.

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Sekuła, Sylwia. "Inhibition of c-Jun-ATF2 phosphorylation, transrepression of c-Jun-c-Fos two modes of regulation of the transcription factor AP-1 activity by glucocorticoid receptor." Karlsruhe Forschungszentrum Karlsruhe, 2006. http://d-nb.info/987710435/34.

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Boeuf, Hélène. "Le gene eiiae d'adenovirus : un systeme modele pour l'etude de la transactivation transcriptionnelle par les produits du gene tres precoce eia et pour l'etude de facteurs impliques dans le processus de la differenciation cellulaire." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13203.

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