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Dissertations / Theses on the topic 'Transcription'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Elzi, David John. "Transcriptional properties of the Kaiso class of transcription factors /." Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/5027.

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2

Pombo, Ana Maria Pires. "Transcription factories : sites of transcriptional activity in mammalian nuclei." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268165.

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3

Xie, Yunwei. "Nucleosomes, transcription and transcription regulation in Archaea." Connect to resource, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1127830717.

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Thesis (Ph. D.)--Ohio State University, 2005.<br>Title from first page of PDF file. Document formatted into pages; contains xiv, 200 p.; also includes graphics (some col.). Includes bibliographical references (p. 167-197). Available online via OhioLINK's ETD Center

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4

Xie, Yunwei. "nucleosome, transcription and transcription regulation in Archaea." The Ohio State University, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=osu1127830717.

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5

Dennis, Jonathan Hancock. "Transcriptional regulation by Brn 3 POU domain containing transcription factors." Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.249684.

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6

Chambers, Anna Louise. "Transcription termination by a transcription-repair coupling factor." Thesis, University of Bristol, 2005. http://hdl.handle.net/1983/b95a2024-73ae-460d-89bf-3c064a780c78.

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7

Yao, Ya-Li. "Regulation of yy1, a multifunctional transciption [sic] factor /." [Tampa, Fla.] : University of South Florida, 2001. http://purl.fcla.edu/fcla/etd/SFE0000626.

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8

Brehm, Alexander Jorg Georg. "Octamer-dependent transcriptional activation by the embryonal transcription factor Oct-4." Thesis, Open University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338344.

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9

Albhilal, Waleed Sulaiman. "The Arabidopsis thaliana heat shock transcription factor A1b transcriptional regulatory network." Thesis, University of Essex, 2015. http://repository.essex.ac.uk/15732/.

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Plants as sessile organisms have adapted highly sophisticated cellular processes to cope with environmental stress conditions, which include the initiation of complex transcriptional regulatory circuits. The heat shock transcription factors (HSFs) have been shown to be central regulators of plant responses to abiotic and biotic stress conditions. However, the extremely high multiplicity in plant HSF families compared to those of other kingdoms and their unique expression patterns and structures suggest that some of them might have evolved to become major regulators of other non-stress related

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10

Kwek, Kon Yew. "Regulation of general transcription factor IIH (TFIIH) in transcription." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427628.

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11

Toedling, Joern Michael. "Comprehensive analysis of high-throughput experiments for investigating transcription and transcriptional regulation." Thesis, University of Cambridge, 2009. https://www.repository.cam.ac.uk/handle/1810/267885.

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As the number of fully sequenced genomes grows, efforts are shifted towards investigation of functional aspects. One research focus is the transcriptome, the set of all transcribed genomic features. We aspire to understand what features constitute the transcriptome, in which context these are transcribed and how their transcription is regulated. Studies that aim to answer these questions frequently make use of high-throughput technologies that allow for investigation of multiple genomic regions, or transcribed copies of genomic regions, in parallel. In this dissertation, I present three high-t

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12

Truscott, Mary. "The molecular basis of transcriptional activation by the CDP/Cux transcription factor /." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103187.

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The CDP/Cux transcription factor is expressed as a 200 kDa protein that interacts rapidly and transiently with DNA. Proteolytic processing generates a shorter isoform, p110 CDP/Cux, that binds stably to DNA. Processing occurs at the G1/S transition of the cell cycle in normal cells, and constitutively in transformed cells. p110 CDP/Cux stimulates cell proliferation by accelerating entry into S phase. Transgenic mice expressing p110 CDP/Cux are more susceptible to different cancers.<br>CDP/Cux was originally described as a repressor of transcription. My goal was to verify whether CDP/Cux might

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13

Ching, Chi-yun Johannes, and 程子忻. "Transcriptional regulation of p16INK4a expression by the forkhead box transcription factor FOXM1." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2003. http://hub.hku.hk/bib/B29466192.

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14

Cusack, Martin. "The role of DNA methylation on transcription factor occupancy and transcriptional activity." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:7d0b7fe7-dee1-433f-8656-c9ee2a216d48.

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DNA methylation is an epigenetic mark that is deposited throughout the genome of mammals and plays an important role in the maintenance of transcriptionally repressive states across cell divisions. There are two major mechanisms by which DNA methylation has been proposed to act: one involves the recognition of the mark by protein complexes containing histone deacetylases (HDACs) that can remodel the local chromatin. Alternatively, methylation has been suggested to directly affect the interaction between transcription factors and their cognate binding sequence. The aim of this research was to d

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15

Xu, Meng. "Specialised transcription factories." Thesis, University of Oxford, 2008. http://ora.ox.ac.uk/objects/uuid:a41d3243-c233-491a-916b-4e329cace434.

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The intimate relationship between the higher-order chromatin organisation and the regulation of gene expression is increasingly attracting attention in the scientific community. Thanks to high-resolution microscopy, genome-wide molecular biology tools (3C, ChIP-on-chip), and bioinformatics, detailed structures of chromatin loops, territories, and nuclear domains are gradually emerging. However, to fully reveal a comprehensive map of nuclear organisation, some fundamental questions remain to be answered in order to fit all the pieces of the jigsaw together. The underlying mechanisms, precisely

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16

Young, David Alan. "Plant mitochondrial transcription." Thesis, University of East Anglia, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338216.

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17

Tucker, Nicholas Peter. "Regulation of transcription by the nitric oxide sensing transcription factor NorR." Thesis, University of East Anglia, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426424.

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18

Lin, Charles Yang. "c-Myc regulates transcriptional pause release and is a global amplifier of transcription." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77782.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Computational and Systems Biology Program, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 203-226).<br>Elevated expression of the c-Myc transcription factor occurs frequently in human cancers and is associated with tumor aggression and poor clinical outcome. However, the predominant mechanism by which c-Myc regulates global transcription in both healthy and tumor cells is poorly understood. In this thesis, I present evidence that c-Myc is a global regulator of RNA Polymerase II (RNA Pol II) trans

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19

SICILIANO, DILETTA. "ANALYSIS OF THE TRANSCRIPTIONAL REGULATION OF MTORC1 ACTIVITY BY MIT/TFE TRANSCRIPTION FACTORS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/607642.

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The mechanistic Target Of Rapamycin Complex 1 (mTORC1) regulates cellular biosynthetic pathways in response to variations in nutrient availability. Activation of mTORC1 is mediated by Rag GTPases, that act as heterodimers and promote mTORC1 recruitment to the lysosome. Many studies have clarified the post-translational control of mTORC1, but little is known about its transcriptional regulation. Our study demonstrates that TFEB, TFE3 and MITF, members of the MiT/TFE family of transcription factors and master regulators of lysosomal and melanosomal biogenesis and autophagy, are nutrient-sensitiv

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20

Immarigeon, Clément. "Role of mediator complex subunits in transcriptional regulation by GATA and FOG transcription factors during Drosophila development." Toulouse 3, 2014. http://thesesups.ups-tlse.fr/2654/.

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Un enjeu majeur en Biologie est de comprendre comment les milliers de gènes composant le génome sont contrôlés afin d'être exprimés dans les bonnes cellules au bon moment. Cette régulation a lieu en grande partie à l'étape de pré-initiation de la transcription. Ce processus résulte de l'action concertée de nombreuses protéines, dont le complexe Médiateur (MED, ~30 sous-unités protéiques ou SU, >1,5MDa) qui joue un rôle conservé dans la régulation de la transcription des gènes par l'ARN Polymérase II (PolII), de la levure à l'Homme. Ce complexe se lie simultanément à la PolII et aux facteurs

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21

Talvik, Gertrud. "Transcription regulation in Plasmodium falciparum : functional characterisation of general transcription factor IIB." Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/20616.

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Plasmodium falciparum is the causative agent of the most severe form of malaria and continues to pose challenges to international healthcare, with high mortality rates and emergence of drug-resistant strains. Plasmodium falciparum has multiple sexual and asexual lifecycle stages within its Anopheline mosquito and human hosts, accompanied by distinct morphological changes. The complex lifecycle, along with the ability to adjust rapidly to different environmental niches, is governed by highly regulated and tightly synchronised changes in stage-specific gene expression. In eukaryotes, regulation

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22

Shah, Sheila Marie Alojipan. "Studies on RNA polymerase III transcription : Structural organization of transcription factor IIIb /." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2001. http://wwwlib.umi.com/cr/ucsd/fullcit?p3025949.

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23

Li, Yuxin. "The DEC1 transcription factor : oncogenic involvement and molecular mechanisms on transcription regulation /." View online ; access limited to URI, 2003. http://0-wwwlib.umi.com.helin.uri.edu/dissertations/dlnow/3115632.

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24

Johansson, Kajsa. "Transcription of Historical Encrypted Manuscripts : Evaluation of an automatic interactive transcription tool." Thesis, Uppsala universitet, Institutionen för lingvistik och filologi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-385254.

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Countless of historical sources are saved in national libraries and archives all over the world and contain important information about our history. Some of these sources are encrypted to prevent people from reading it. This thesis examines a semi-automated Interactive transcription Tool based on unsupervised learning without any labelled training data that has been developed for transcription of encrypted sources and compares it to manual transcription. The interactive transcription tool is based on handwritten text recognition techniques and the system identifies cluster of symbols based on

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25

Sydow, Jasmin F. "Structural basis of transcription." Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-107071.

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26

Min, Mi-Kyung. "Baculovirus vector transcription analyses." Thesis, University of Oxford, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.279873.

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27

Rennick, L. J. "Transcription attenuation in morbilliviruses." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403206.

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28

Hennigan, Aidan Noel. "Transcription in Methanococcus vannielii /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487841975356207.

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29

An, Sungwhan. "Mechanism of coronavirus transcription /." Digital version accessible at:, 1998. http://wwwlib.umi.com/cr/utexas/main.

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30

Ferrara, Giovanni Antonio. "Studies of transcriptional regulation by the vitamin D3 receptor and cAMP-responsive transcription factors." Thesis, McGill University, 1993. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=69734.

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Cells of complex organisms communicate with each other by sending molecular signals. These signals can be classified by their solubility properties. Hydrophilic signals, in the form of peptides or small hydrophilic molecules, interact with extracellular receptors located on the surface of target cells. Binding of ligand to its receptor leads to transduction of an intracellular signal via a second messenger. Lipophilic signals (steroids, vitamin D$ sb3$, thyroid hormone, and retinoids) traverse the plasma membrane and bind to specific intracellular proteins, known collectively as nuclear recept

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31

Kiosses, Theodore. "DNA binding specificity and transcriptional regulation of Six4 : a myotonic dystrophy associated transcription factor." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/3948.

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Attaining an understanding of the mechanisms underpinning development has been amongst the cardinal scientific challenges of our age. The transition from a single cell organism to the level of complexity evidenced in higher eukaryotes has been facilitated by the advent of intricate developmental networks involving a plethora of factors that synergise to allow for precise spatio-temporal expression of the proteins present in higher organisms. Development is often portrayed as a domino like cascade of events stemming from relatively uncomplicated origins that go on to branch out and form associa

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32

Rheinheimer, Brenna Ann. "Alternative Transcription Of The SLIT2/Mir-218-1 Transcriptional Axis Mediates Pancreatic Cancer Invasion." Diss., The University of Arizona, 2016. http://hdl.handle.net/10150/605118.

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The development of several organ systems through modeling and shaping of the tissue structure occurs from signaling through axon guidance molecules. The Slit family of ligands has been shown to regulate branching morphogenesis in mammary gland duct development and loss of Slit gene expression during this time leads to the formation of hyperplastic, disorganized lesions suggesting a potential role for Slits in cancer formation. Characterization of human pancreatic ductal adenocarcinoma cell lines showed a loss of SLIT2 expression in cells that contain activated Kras. Loss of SLIT2 expression wa

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33

Smith, Richard LeRoy. "Cis-regulatory Sequence and Co-regulatory Transcription Factor Functions in ERα-Mediated Transcriptional Repression". BYU ScholarsArchive, 2009. https://scholarsarchive.byu.edu/etd/2261.

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Estrogens exert numerous actions throughout the human body, targeting healthy tissue while also enhancing the proliferative capacity of breast cancers. Estrogen signaling is mediated by the estrogen receptor (ER), which binds DNA and ultimately affects the expression of adjacent genes. Current understanding of ER-mediated transcriptional regulation is mostly limited to genes whose transcript levels increase following estrogen exposure, though recent studies demonstrate that direct down-regulation of estrogen-responsive genes is also a significant feature of ER action. We hypothesized that diff

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34

Chery, Alicia. "Rôle de la transcription pervasive antisens chez Saccharomyces cerevisiae dans la régulation de l'expression des gènes." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066191/document.

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L'expression des gènes est finement régulée dans la cellule et soumise à de multiples contrôles-qualité. Cette régulation intervient à différents niveaux, de façon à garantir une synthèse efficace des produits fonctionnels de l'expression génique, et pour assurer une adaptation à un changement environnemental. Notamment, les régulations transcriptionnelles sont cruciales pour contrôler la cinétique et le niveau d'expression des gènes. La transcription pervasive est une transcription généralisée non-codante et instable qui fut révélée chez la levure Saccharomyces cerevisiae. Bien que son potent

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35

Qingquan, Liu. "Investigating the mechanisms of growth factor independence-1 (Gfi-1)-mediated transcriptional repression of p21Cip1 and MBP." Toledo, Ohio : University of Toledo, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=toledo1241726388.

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Dissertation (Ph.D.)--University of Toledo, 2009.<br>Typescript. "Submitted as partial fulfillment of the requirements for The Doctor of Philosophy in Biology." "A dissertation entitled"--at head of title. Title from title page of PDF document. Bibliography: p. 84-97.

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36

Zandvakili, Arya. "The Role of Affinity and Arrangement of Transcription Factor Binding Sites in Determining Hox-regulated Gene Expression Patterns." University of Cincinnati / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1535708748728472.

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37

Ngondo, Richard Patryk. "Caractérisation du potentiel régulateur du facteur de transcription ZNF143." Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ078.

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Des données suggéraient que le facteur de transcription ZNF143 régule l’expression de milliers de gènes mais très peu d’informations étaient disponibles sur les gènes cibles, réseaux de gènes, processus biologiques et mécanismes impliquant ZNF143. Pour mon travail de thèse je me suis intéressé au potentiel régulateur de ce facteur en particulier chez l’homme. Mon projet de recherche a premièrement consisté à identifier toutes les cibles génomiques de ZFN143 puis à caractériser fonctionnellement cet interactome. Les résultats obtenus ont permis d’identifier plus de 3000 gènes cibles de ZNF143,

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38

MacKinnon-Roy, Christine. "The role of transcription elongation factor IIS in transcription-coupled nucleotide excision repair." Thesis, University of Ottawa (Canada), 2010. http://hdl.handle.net/10393/28454.

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Transcription-coupled nucleotide excision repair (TC-NER) removes bulky DNA lesions from the template strand at actively transcribed genes. The RNA polymerase II (RNAPII) holoenzyme complex forms a stable ternary complex at the site of DNA damage which may block access of DNA repair proteins to the site of DNA lesions. Therefore, there is considerable interest in understanding how repair is coupled to transcription. Based on elegant in vitro studies, it has been hypothesized that transcription elongation factor IIS (TFIIS), by catalyzing the reverse translocation of RNAPII, may allow access o

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39

Barthel, Kristen Kara Bjorkman. "Mammalian strategies to regulate transcription: Transcription factor sumoylation and cis-regulatory region identification." Connect to online resource, 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3284477.

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40

Trevett, Julie A. "Teacher-transcription and self-transcription as aids for teaching and learning jazz improvisation." Thesis, University of Exeter, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421583.

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41

Roberts, Karen. "Regulation of melanocyte-specific transcription by the transcription factors BRN-2 and microphthalmia." Thesis, Institute of Cancer Research (University Of London), 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.286144.

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42

Briand, Jean-Baptiste. "Etude du contrôle de la transcription envahissante par la terminaison de la transcription." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112079/document.

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La terminaison de la transcription est essentielle, aussi bien pour assurer la formation de l’extrémité 3’ de transcrits fonctionnels que pour éviter les phénomènes d’interférence transcriptionnelle entre des régions transcrites adjacentes. Ceci est particulièrement important dans un génome compact comme celui de S. cerevisiae. La terminaison est aussi l’une des stratégies principales que la cellule emploie pour contrôler et limiter la transcription dite envahissante ou cachée. Chez S. cerevisiae, l’ARN polymérase II est responsable de la transcription des ARNm et de nombreuses classes d’ARN n

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43

Burton, Elliot N. "Functional Consequences of mtDNA Methylation on Mitochondrial Transcription Factor Binding and Transcription Initiation." VCU Scholars Compass, 2016. http://scholarscompass.vcu.edu/etd/4185.

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The role of cytosine modifications on nuclear transcription has been well characterized, but the function of DNA methylation in the mitochondrial genome has not been determined. Previous studies conducted by the Taylor laboratory have shown overexpression of the mitochondrial isoform of DNMT1 leads to strand-specific changes in gene expression. Here, we show that increased mtDNMT1 expression leads to an increase in the polycistronic transcript encoding the ND1 and Cox1 sequences. In order to understand the mechanistic basis of these changes, we investigated the effects of CpG methylation in th

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44

Eustis, Robyn Lynn. "The Role of Pyrococcus furiosus Transcription Factor E in Transcription Iniitiation." PDXScholar, 2015. https://pdxscholar.library.pdx.edu/open_access_etds/2522.

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All sequenced archaeal genomes encode a general transcription factor, TFE, which is highly conserved and homologous to the alpha subunit of the eukaryotic transcription factor TFIIE. TFE functions to increase promoter opening efficiency during transcription initiation, although the mechanism for this is unclear. The N-terminus of TFE contains a common DNA binding motif, a winged helix. At the tip of this winged helix is a highly conserved region of aromatic amino acids that is close to DNA during initiation. TFE activation can compensate for mutations in another transcription factor, TFB2, whi

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45

Palagi, Alexandre. "Découverte et analyse d’inactivateurs de transcription chez la Drosophile agissant comme amplificateurs dans différents contextes cellulaires." Thesis, Université Côte d'Azur (ComUE), 2018. http://www.theses.fr/2018AZUR4006.

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Un des enjeux majeurs de la biologie moderne est de comprendre les mécanismes complexes régissant l’expression de gènes d’un organisme en développement. Alors que les activateurs (enhancers) ont été abondamment étudiés et analysés, seul un relatif petit nombre de répresseurs (silencers) a été identifié à ce jour et restent jusqu’à présent assez mal compris. Un nombre non négligeable de CRMs jouent par ailleurs un double rôle à la fois d’amplificateurs et d’inactivateurs de transcription en fonction de l’état ou du type cellulaire dans lequel ils se trouvent, rajoutant un niveau supplémentaire

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46

Greberg, Maria Hellqvist. "Cloning and characterization of FREACs, human forkhead transcription factors." Göteborg : Dept. of Cell and Molecular Biology, Göteborg University, 1997. http://catalog.hathitrust.org/api/volumes/oclc/39751934.html.

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47

GHNEIM, NADA. "Relations entre les codes de l'oral et de l'écrit : Contraintes et ambiguïtés." Grenoble 3, 1997. http://www.theses.fr/1997GRE39023.

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Cette etude a pour objet l'etude des relations bidrectionnelles entre le code de l'ecrit et celui de l'oral. Le support de ce travail est une grammaire de transcription orthographique-phonetique toph (phonetisation), et sa grammaire inverse de transcription phonetique-orthographique phot (orthographisation). Le formalisme de la grammaire de phonetisation de toph a ete etendu pour permettre d'elargir son champ de couverture de la langue. Differents outils d'analyse logique des grammaires de phonetisation ont ete developpes pour tracer et modifier la grammaire afin d'assurer la coherence entre l

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48

Apostolov, Apostol. "Studying the posttranslational modifications of transcription factor Ikaros and their role in its function." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00923158.

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The main topic of my PhD studies was to investigate the role of sumoylation in the function of Ikaros transcription factor, that regulates the lymphocyte differentiation and function. Sumoylation is a posttranslational modification that can change the properties and regulate the function of a given protein. Up to now, one study addressed the question of how sumoylationmodulates Ikaros function. It shows that Ikaros is sumoylated in total primary thymocytes, and that this dynamic event modulates Ikaros' repressive function. It also describes two consensus sumoylation sites on Ikaros (K58 and K2

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49

Liu, Xun. "Transcription-dependent and transcription-independent functions of the classical progesterone receptor in Xenopus ovaries." Thesis, University of Ottawa (Canada), 2004. http://hdl.handle.net/10393/26700.

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The physiological functions of the classical progesterone receptor (XPR) in regulating oocyte maturation and ovulation in Xenopus laevis remain controversial. Using antibodies generated against cloned XPR, I demonstrated here that the somatic follicle cells expressed an 80 kDa XPR protein, termed XPR-1. XPR-1 underwent progesterone-induced, proteasome-mediated degradation. A smaller (&sim;70 kDa) XPR protein, termed XPRo, was expressed in oocytes, but not in follicle cells. XPRo underwent progesterone-induced hyperphosphorylation, but not degradation. Treating isolated ovaries with progesteron

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50

Wu, Ming-Hsiao. "Temperature Dependent Transcription Initiation in Archaea: Interplay between Transcription Factor B and Promoter Sequence." PDXScholar, 2014. https://pdxscholar.library.pdx.edu/open_access_etds/2021.

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In Pyrococcus furiosus (Pfu), a hyperthermophile archaeon, two transcription factor Bs, TFB1 and TFB2 are encoded in the genomic DNA. TFB1 is the primary TFB in Pfu, and is homologous to transcription factor IIB (TFIIB) in eukaryotes. TFB2 is proposed to be a secondary TFB that is compared to TFB1, TFB2 lacks the conserved B-finger / B-reader / B-linker regions which assist RNA polymerase in transcription start site selection and promoter opening functions respectively. P. furiosus, like all Archaea, encodes a single transcription factor E (TFE), that is homologous to the N-terminus of transcr

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