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Journal articles on the topic 'Transcription'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Sheldon, Michael, and Reinberg Danny. "Transcriptional Activation: Tuning-up transcription." Current Biology 5, no. 1 (1995): 43–46. http://dx.doi.org/10.1016/s0960-9822(95)00014-5.

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2

Hensel, Zach, Haidong Feng, Bo Han, et al. "Transcription Activation via Transcriptional Bursting." Biophysical Journal 100, no. 3 (2011): 167a. http://dx.doi.org/10.1016/j.bpj.2010.12.1129.

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3

Deshmukh, Pallavi, Lalita Shinde, and Namrata Ahire Sayli Kamod. "Transcription Management System." International Journal of Trend in Scientific Research and Development Volume-2, Issue-3 (2018): 2100–2103. http://dx.doi.org/10.31142/ijtsrd11433.

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4

Wilson, Nicola K., Fernando J. Calero-Nieto, Rita Ferreira, and Berthold Göttgens. "Transcriptional regulation of haematopoietic transcription factors." Stem Cell Research & Therapy 2, no. 1 (2011): 6. http://dx.doi.org/10.1186/scrt47.

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5

Melamed, Philippa, Yahav Yosefzon, Sergei Rudnizky, and Lilach Pnueli. "Transcriptional enhancers: Transcription, function and flexibility." Transcription 7, no. 1 (2016): 26–31. http://dx.doi.org/10.1080/21541264.2015.1128517.

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6

Zhang, Yuli, and Linlin Hou. "Alternate Roles of Sox Transcription Factors beyond Transcription Initiation." International Journal of Molecular Sciences 22, no. 11 (2021): 5949. http://dx.doi.org/10.3390/ijms22115949.

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Sox proteins are known as crucial transcription factors for many developmental processes and for a wide range of common diseases. They were believed to specifically bind and bend DNA with other transcription factors and elicit transcriptional activation or repression activities in the early stage of transcription. However, their functions are not limited to transcription initiation. It has been showed that Sox proteins are involved in the regulation of alternative splicing regulatory networks and translational control. In this review, we discuss the current knowledge on how Sox transcription f

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7

Rullan, Marc, Dirk Benzinger, W. Schmidt Gregor, Andreas Milias-Argeitis, and Khammash Mustafa. "An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation." Molecular Cell 70, no. 48 (2018): 745–56. https://doi.org/10.1016/j.molcel.2018.04.012.

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<strong>Highlights</strong> Live single-cell quantification of light-activated transcriptional bursts in yeast A platform for precise light targeting enables single-cell dynamic feedback control Single-cell regulation markedly reduces cell-to-cell variability Transcription factor activity modulates burst timing and duration   <strong>Summary</strong> Transcription is a highly regulated and inherently stochastic process. The complexity of signal transduction and gene regulation makes it challenging to analyze how the dynamic activity of transcriptional regulators affects stochast

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8

Geng, Yanbiao, Peter Laslo, Kevin Barton, and Chyung-Ru Wang. "Transcriptional Regulation ofCD1D1by Ets Family Transcription Factors." Journal of Immunology 175, no. 2 (2005): 1022–29. http://dx.doi.org/10.4049/jimmunol.175.2.1022.

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9

Hermsen, Rutger, Sander Tans, and Pieter Rein ten Wolde. "Transcriptional Regulation by Competing Transcription Factor Modules." PLoS Computational Biology 2, no. 12 (2006): e164. http://dx.doi.org/10.1371/journal.pcbi.0020164.

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10

Hermsen, Rutger, Sander J. Tans, and Pieter Rein ten Wolde. "Transcriptional Regulation by Competing Transcription Factor Modules." PLoS Computational Biology preprint, no. 2006 (2005): e164. http://dx.doi.org/10.1371/journal.pcbi.0020164.eor.

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11

Bettegowda, Anilkumar, and Miles F. Wilkinson. "Transcription and post-transcriptional regulation of spermatogenesis." Philosophical Transactions of the Royal Society B: Biological Sciences 365, no. 1546 (2010): 1637–51. http://dx.doi.org/10.1098/rstb.2009.0196.

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Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards understanding such regulatory mechanisms and identifies future challenges to be addressed in this field. We focus on transcription factors, chromatin-associated factors and RNA-binding proteins necessary for spermatogenesis and/or sperm maturati

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12

Senecal, Adrien, Brian Munsky, Florence Proux, et al. "Transcription Factors Modulate c-Fos Transcriptional Bursts." Cell Reports 8, no. 1 (2014): 75–83. http://dx.doi.org/10.1016/j.celrep.2014.05.053.

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13

Fuhrken, Peter G., Chi Chen, Pani A. Apostolidis, Min Wang, William M. Miller, and Eleftherios T. Papoutsakis. "Gene Ontology-driven transcriptional analysis of CD34+cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis." Physiological Genomics 33, no. 2 (2008): 159–69. http://dx.doi.org/10.1152/physiolgenomics.00127.2007.

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Differentiation of hematopoietic stem and progenitor cells is an intricate process controlled in large part at the level of transcription. While some key megakaryocytic transcription factors have been identified, the complete network of megakaryocytic transcriptional control is poorly understood. Using global gene expression microarray analysis, Gene Ontology-based functional annotations, and a novel interlineage comparison with parallel, isogenic granulocytic cultures as a negative control, we closely examined the mRNA level of transcriptional regulators in megakaryocytes derived from human m

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14

Hampsey, Michael. "Molecular Genetics of the RNA Polymerase II General Transcriptional Machinery." Microbiology and Molecular Biology Reviews 62, no. 2 (1998): 465–503. http://dx.doi.org/10.1128/mmbr.62.2.465-503.1998.

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SUMMARY Transcription initiation by RNA polymerase II (RNA pol II) requires interaction between cis-acting promoter elements and trans-acting factors. The eukaryotic promoter consists of core elements, which include the TATA box and other DNA sequences that define transcription start sites, and regulatory elements, which either enhance or repress transcription in a gene-specific manner. The core promoter is the site for assembly of the transcription preinitiation complex, which includes RNA pol II and the general transcription fctors TBP, TFIIB, TFIIE, TFIIF, and TFIIH. Regulatory elements bin

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15

Coulombe, Benoit. "DNA wrapping in transcription initiation by RNA polymerase II." Biochemistry and Cell Biology 77, no. 4 (1999): 257–64. http://dx.doi.org/10.1139/o99-028.

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The DNA wrapping model of transcription stipulates that DNA bending and wrapping around RNA polymerase causes an unwinding of the DNA helix at the enzyme catalytic center that stimulates strand separation prior to initiation and during transcript elongation. Recent experiments with mammalian RNA polymerase II indicate the significance of DNA bending and wrapping in transcriptional mechanisms. These findings have important implications in our understanding of the role of the general transcription factors in transcriptional initiation and the mechanisms underlying transcriptional regulation.Key

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16

Kassavetis, G. A., and E. P. Geiduschek. "Transcription factor TFIIIB and transcription by RNA polymerase III." Biochemical Society Transactions 34, no. 6 (2006): 1082–87. http://dx.doi.org/10.1042/bst0341082.

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pol (RNA polymerase) III is charged with the task of transcribing nuclear genes encoding diverse small structural and catalytic RNAs. We present a brief review of the current understanding of several aspects of the pol III transcription apparatus. The focus is on yeast and, more specifically, on Saccharomyces cerevisiae; preponderant attention is given to the TFs (transcription initiation factors) and especially to TFIIIB, which is the core pol III initiation factor by virtue of its role in recruiting pol III to the transcriptional start site and its essential roles in forming the transcriptio

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17

Yunger, Sharon, Pinhas Kafri, Liat Rosenfeld, et al. "S-phase transcriptional buffering quantified on two different promoters." Life Science Alliance 1, no. 5 (2018): e201800086. http://dx.doi.org/10.26508/lsa.201800086.

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Imaging of transcription by quantitative fluorescence-based techniques allows the examination of gene expression kinetics in single cells. Using a cell system for the in vivo visualization of mammalian mRNA transcriptional kinetics at single-gene resolution during the cell cycle, we previously demonstrated a reduction in transcription levels after replication. This phenomenon has been described as a homeostasis mechanism that buffers mRNA transcription levels with respect to the cell cycle stage and the number of transcribing alleles. Here, we examined how transcriptional buffering enforced du

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18

Dunstan, H. M., L. S. Young, and K. U. Sprague. "tRNA(IleIAU) (TFIIIR) plays an indirect role in silkworm class III transcription in vitro and inhibits low-frequency DNA cleavage." Molecular and Cellular Biology 14, no. 6 (1994): 3596–603. http://dx.doi.org/10.1128/mcb.14.6.3596-3603.1994.

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tRNA(IleIAU) provides an activity, originally called TFIIIR, necessary to reconstitute transcription by silkworm RNA polymerase III in vitro from partially purified components. Here we report studies on the role of tRNA(IleIAU) in in vitro transcription. We show that tRNA(IleIAU) does not act positively but, rather, is required to prevent the action of a transcriptional inhibitor. We also show that the presence of tRNA(IleIAU) in transcription reaction mixtures prevents low-frequency DNA cleavage by the TFIIIB fraction. Studies on the mechanism of transcriptional inhibition suggest that this D

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19

Dunstan, H. M., L. S. Young, and K. U. Sprague. "tRNA(IleIAU) (TFIIIR) plays an indirect role in silkworm class III transcription in vitro and inhibits low-frequency DNA cleavage." Molecular and Cellular Biology 14, no. 6 (1994): 3596–603. http://dx.doi.org/10.1128/mcb.14.6.3596.

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tRNA(IleIAU) provides an activity, originally called TFIIIR, necessary to reconstitute transcription by silkworm RNA polymerase III in vitro from partially purified components. Here we report studies on the role of tRNA(IleIAU) in in vitro transcription. We show that tRNA(IleIAU) does not act positively but, rather, is required to prevent the action of a transcriptional inhibitor. We also show that the presence of tRNA(IleIAU) in transcription reaction mixtures prevents low-frequency DNA cleavage by the TFIIIB fraction. Studies on the mechanism of transcriptional inhibition suggest that this D

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20

O’Callaghan, Chris, Da Lin, and Thomas K. Hiron. "Intragenic transcriptional interference regulates the human immune ligand MICA." Journal of Immunology 200, no. 1_Supplement (2018): 109.23. http://dx.doi.org/10.4049/jimmunol.200.supp.109.23.

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Abstract Regulation of MICA expression is incompletely understood, but human MICA can be upregulated in cancer cells, virus-infected cells and rapidly proliferating cells. Binding of MICA to the activating NKG2D receptor on cytotoxic immune cells promotes elimination of the cell expressing MICA. We noted that MICA has tandem promoters that drive overlapping forward transcription. We show that the MICA gene contains a conserved upstream promoter that expresses a non coding transcript. Transcription from the upstream promoter represses transcription from the standard downstream MICA promoter in

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21

ARAO, Yukitomo, Etsuko YAMAMOTO, Naoto MIYATAKE, et al. "A synthetic oestrogen antagonist, tamoxifen, inhibits oestrogen-induced transcriptional, but not post-transcriptional, regulation of gene expression." Biochemical Journal 313, no. 1 (1996): 269–74. http://dx.doi.org/10.1042/bj3130269.

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Oestrogen (E2) regulates the expression of its target genes at transcriptional and post-transcriptional levels. To clarify the mechanism of E2-induced post-transcriptional regulation, with attention to the involvement of the oestrogen receptor (ER), we studied the effect of tamoxifen (TAM), a synthetic E2 antagonist that inhibits ER-mediated transcription, on E2-induced transcriptional and post-transcriptional regulation of the chicken ovalbumin (OVA) gene in chick oviducts. Run-on analysis with oviduct nuclei isolated from E2-treated chicks showed that TAM treatment completely blocked E2-indu

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22

Spector, M. S., A. Raff, H. DeSilva, K. Lee, and M. A. Osley. "Hir1p and Hir2p function as transcriptional corepressors to regulate histone gene transcription in the Saccharomyces cerevisiae cell cycle." Molecular and Cellular Biology 17, no. 2 (1997): 545–52. http://dx.doi.org/10.1128/mcb.17.2.545.

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The HIR/HPC (histone regulation/histone periodic control) negative regulators play important roles in the transcription of six of the eight core histone genes during the Saccharomyces cerevisiae cell cycle. The phenotypes of hir1 and hir2 mutants suggested that the wild-type HIR1 and HIR2 genes encode transcriptional repressors that function in the absence of direct DNA binding. When Hir1p and Hir2p were artificially tethered to yeast promoters, each protein repressed transcription, suggesting that they represent a new class of transcriptional corepressors. The two proteins might function as a

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23

Yu, Wangjie, Hao Zheng, Jeffrey L. Price, and Paul E. Hardin. "DOUBLETIME Plays a Noncatalytic Role To Mediate CLOCK Phosphorylation and Repress CLOCK-Dependent Transcription within the Drosophila Circadian Clock." Molecular and Cellular Biology 29, no. 6 (2009): 1452–58. http://dx.doi.org/10.1128/mcb.01777-08.

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ABSTRACT Circadian clocks keep time via gene expression feedback loops that are controlled by time-of-day-specific changes in the synthesis, activity, and degradation of transcription factors. Within the Drosophila melanogaster circadian clock, DOUBLETIME (DBT) kinase is necessary for the phosphorylation of PERIOD (PER), a transcriptional repressor, and CLOCK (CLK), a transcriptional activator, as CLK-dependent transcription is being repressed. PER- and DBT-containing protein complexes feed back to repress CLK-dependent transcription, but how DBT promotes PER and CLK phosphorylation and how PE

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24

Lv, Xiaoyang, Wei Sun, Shuangxia Zou, Ling Chen, Joram M. Mwacharo, and Jinyu Wang. "Characteristics of the BMP7 Promoter in Hu Sheep." Animals 9, no. 11 (2019): 874. http://dx.doi.org/10.3390/ani9110874.

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The BMP7 gene is involved in the growth and development of hair follicles but its regulation mechanism is unclear. We studied the regulation mechanism of the BMP7 promoter by cloning the proximal promoter of BMP7 for bioinformatics analysis. A series of missing vectors was then constructed for dual-fluorescein activity detection based on the bioinformatics analysis results. We tested transcription-factor binding-site mutations and transcription factor over-expression to analyze the transcriptional regulation principle of the BMP7 promoter region. The upstream transcriptional regulatory region

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25

Dalmia, Anupam, and Chanchal Goinka. "Prognostic Roles of Mitochondrial Transcription Termination Factor 1 and Mitochondrial Transcription Elongation Factor in Colon Adenocarcinoma." International Journal of Science and Research (IJSR) 11, no. 7 (2022): 1134–42. http://dx.doi.org/10.21275/sr22716202821.

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26

Shih, H. M., C. C. Chang, H. Y. Kuo, and D. Y. Lin. "Daxx mediates SUMO-dependent transcriptional control and subnuclear compartmentalization." Biochemical Society Transactions 35, no. 6 (2007): 1397–400. http://dx.doi.org/10.1042/bst0351397.

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SUMO (small ubiquitin-related modifier) modification is emerging as an important post-translational control in transcription. In general, SUMO modification is associated with transcriptional repression. Although many SUMO-modified transcription factors and co-activators have been identified, little is known about the mechanism underlying SUMOylation-elicited transcriptional repression. Here, we summarize that SUMO modification of transcription factors such as androgen receptor, glucocorticoid receptor, Smad4 and CBP [CREB (cAMP-response-element-binding protein)-binding protein] co-activator re

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27

Grichnik, J. M., B. A. French, and R. J. Schwartz. "The chicken skeletal alpha-actin gene promoter region exhibits partial dyad symmetry and a capacity to drive bidirectional transcription." Molecular and Cellular Biology 8, no. 11 (1988): 4587–97. http://dx.doi.org/10.1128/mcb.8.11.4587-4597.1988.

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The chicken skeletal alpha-actin gene promoter region (-202 to -12) provides myogenic transcriptional specificity. This promoter contains partial dyad symmetry about an axis at nucleotide -108 and in transfection experiments is capable of directing transcription in a bidirectional manner. At least three different transcription initiation start sites, oriented toward upstream sequences, were mapped 25 to 30 base pairs from TATA-like regions. The opposing transcriptional activity was potentiated upon the deletion of sequences proximal to the alpha-actin transcription start site. Thus, sequences

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28

Grichnik, J. M., B. A. French, and R. J. Schwartz. "The chicken skeletal alpha-actin gene promoter region exhibits partial dyad symmetry and a capacity to drive bidirectional transcription." Molecular and Cellular Biology 8, no. 11 (1988): 4587–97. http://dx.doi.org/10.1128/mcb.8.11.4587.

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The chicken skeletal alpha-actin gene promoter region (-202 to -12) provides myogenic transcriptional specificity. This promoter contains partial dyad symmetry about an axis at nucleotide -108 and in transfection experiments is capable of directing transcription in a bidirectional manner. At least three different transcription initiation start sites, oriented toward upstream sequences, were mapped 25 to 30 base pairs from TATA-like regions. The opposing transcriptional activity was potentiated upon the deletion of sequences proximal to the alpha-actin transcription start site. Thus, sequences

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29

Kaminski, Tim Patrick, Jan Peter Siebrasse, and Ulrich Kubitscheck. "Transcription regulation during stable elongation by a reversible halt of RNA polymerase II." Molecular Biology of the Cell 25, no. 14 (2014): 2190–98. http://dx.doi.org/10.1091/mbc.e14-02-0755.

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Regulation of RNA polymerase II (RNAPII) during transcription is essential for controlling gene expression. Here we report that the transcriptional activity of RNAPII at the Balbiani ring 2.1 gene could be halted during stable elongation in salivary gland cells of Chironomus tentans larvae for extended time periods in a regulated manner. The transcription halt was triggered by heat shock and affected all RNAPII independently of their position in the gene. During the halt, incomplete transcripts and RNAPII remained at the transcription site, the phosphorylation state of RNAPII was unaltered, an

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30

Matthews, J. L., M. G. Zwick, and M. R. Paule. "Coordinate regulation of ribosomal component synthesis in Acanthamoeba castellanii: 5S RNA transcription is down regulated during encystment by alteration of TFIIIA activity." Molecular and Cellular Biology 15, no. 6 (1995): 3327–35. http://dx.doi.org/10.1128/mcb.15.6.3327.

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Transcription of large rRNA precursor and 5S RNA were examined during encystment of Acanthamoeba castellanii. Both transcription units are down regulated almost coordinately during this process, though 5S RNA transcription is not as completely shut down as rRNA transcription. The protein components necessary for transcription of 5S RNA and tRNA were determined, and fractions containing transcription factors comparable to TFIIIA, TFIIIB, and TFIIIC, as well as RNA polymerase III and a 3'-end processing activity, were identified. Regulation of 5S RNA transcription could be recapitulated in vitro

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31

Lopez, Alex B., Chuanping Wang, Charlie C. Huang, et al. "A feedback transcriptional mechanism controls the level of the arginine/lysine transporter cat-1 during amino acid starvation." Biochemical Journal 402, no. 1 (2007): 163–73. http://dx.doi.org/10.1042/bj20060941.

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The adaptive response to amino acid limitation in mammalian cells inhibits global protein synthesis and promotes the expression of proteins that protect cells from stress. The arginine/lysine transporter, cat-1, is induced during amino acid starvation by transcriptional and post-transcriptional mechanisms. It is shown in the present study that the transient induction of cat-1 transcription is regulated by the stress response pathway that involves phosphorylation of the translation initiation factor, eIF2 (eukaryotic initiation factor-2). This phosphorylation induces expression of the bZIP (bas

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32

Acevedo, Mari Luz, and W. Lee Kraus. "Transcriptional activation by nuclear receptors." Essays in Biochemistry 40 (June 1, 2004): 73–88. http://dx.doi.org/10.1042/bse0400073.

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Transcriptional activation by nuclear receptors (NRs) involves the recruitment of distinct classes of co-activators and other transcription-related factors to target promoters in the chromatin environment of the nucleus. Chromatin has a general repressive effect on transcription, but also provides opportunities for NRs to regulate transcription by directing specific patterns of chromatin remodelling and histone modification. Ultimately, the transcription of hormone-regulated genes by NRs is critically dependent on co-ordinated physical and functional interactions among the receptors, chromatin

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33

Pedro, Kyle D., Luis M. Agosto, Jared A. Sewell, et al. "A functional screen identifies transcriptional networks that regulate HIV-1 and HIV-2." Proceedings of the National Academy of Sciences 118, no. 11 (2021): e2012835118. http://dx.doi.org/10.1073/pnas.2012835118.

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The molecular networks involved in the regulation of HIV replication, transcription, and latency remain incompletely defined. To expand our understanding of these networks, we performed an unbiased high-throughput yeast one-hybrid screen, which identified 42 human transcription factors and 85 total protein–DNA interactions with HIV-1 and HIV-2 long terminal repeats. We investigated a subset of these transcription factors for transcriptional activity in cell-based models of infection. KLF2 and KLF3 repressed HIV-1 and HIV-2 transcription in CD4+ T cells, whereas PLAGL1 activated transcription o

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34

Fu, Yan-Fang, Ting-Ting Du, Mei Dong та ін. "Mir-144 selectively regulates embryonic α-hemoglobin synthesis during primitive erythropoiesis". Blood 113, № 6 (2009): 1340–49. http://dx.doi.org/10.1182/blood-2008-08-174854.

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Abstract Precise transcriptional control of developmental stage-specific expression and switching of α- and β-globin genes is significantly important to understand the general principles controlling gene expression and the pathogenesis of thalassemia. Although transcription factors regulating β-globin genes have been identified, little is known about the microRNAs and trans-acting mechanism controlling α-globin genes transcription. Here, we show that an erythroid lineage-specific microRNA gene, miR-144, expressed at specific developmental stages during zebrafish embryogenesis, negatively regul

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35

Smith, J. S. "TRANSCRIPTION: Is S Phase Important for Transcriptional Silencing?" Science 291, no. 5504 (2001): 608–9. http://dx.doi.org/10.1126/science.291.5504.608.

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36

Munshi, Rahul. "How Transcription Factor Clusters Shape the Transcriptional Landscape." Biomolecules 14, no. 7 (2024): 875. http://dx.doi.org/10.3390/biom14070875.

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In eukaryotic cells, gene transcription typically occurs in discrete periods of promoter activity, interspersed with intervals of inactivity. This pattern deviates from simple stochastic events and warrants a closer examination of the molecular interactions that activate the promoter. Recent studies have identified transcription factor (TF) clusters as key precursors to transcriptional bursting. Often, these TF clusters form at chromatin segments that are physically distant from the promoter, making changes in chromatin conformation crucial for promoter–TF cluster interactions. In this review,

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37

Nikolenko, J. V., Yu V. Shidlovskii, L. A. Lebedeva, A. N. Krasnov, S. G. Georgieva, and E. N. Nabirochkina. "Transcriptional Coactivator SAYP Can Suppress Transcription in Heterochromatin." Russian Journal of Genetics 41, no. 8 (2005): 840–43. http://dx.doi.org/10.1007/s11177-005-0169-7.

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38

Bloor, Adrian, Ekaterina Kotsopoulou, Penny Hayward, Brian Champion, and Anthony Green. "RFP represses transcriptional activation by bHLH transcription factors." Oncogene 24, no. 45 (2005): 6729–36. http://dx.doi.org/10.1038/sj.onc.1208828.

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39

Zhang, Lang, Haoyue Yu, Pan Wang, Qingyang Ding, and Zhao Wang. "Screening of transcription factors with transcriptional initiation activity." Gene 531, no. 1 (2013): 64–70. http://dx.doi.org/10.1016/j.gene.2013.07.054.

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40

Fingerhut, Jaclyn M., Romain Lannes, Troy W. Whitfield, Prathapan Thiru, and Yukiko M. Yamashita. "Co-transcriptional splicing facilitates transcription of gigantic genes." PLOS Genetics 20, no. 6 (2024): e1011241. http://dx.doi.org/10.1371/journal.pgen.1011241.

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Although introns are typically tens to thousands of nucleotides, there are notable exceptions. In flies as well as humans, a small number of genes contain introns that are more than 1000 times larger than typical introns, exceeding hundreds of kilobases (kb) to megabases (Mb). It remains unknown why gigantic introns exist and how cells overcome the challenges associated with their transcription and RNA processing. The Drosophila Y chromosome contains some of the largest genes identified to date: multiple genes exceed 4Mb, with introns accounting for over 99% of the gene span. Here we demonstra

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41

Górska-Kołodziejska, Agata. "The role of transcription in a didactic process on the examples of chamber works scored for piano for four hands and for two pianos." Konteksty Kształcenia Muzycznego 7, no. 1(11) (2020): 11–42. http://dx.doi.org/10.5604/01.3001.0014.6462.

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The aim of the article is to demonstrate the need for employing transcriptions of well-known musical works in the teaching of piano performance for four hands and for two pianos. The origins of the concept of transcription is presented, development of transcription in the context of the history of musical forms is traced back, as well as performance-related aspects of a transcription are analysed. The article shows advantages of a transcription as an arrangement developing the pianist’s technique and art of interpretation. The publication also includes a list of the transcribed pieces availabl

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42

Jones, L., H. Richardson, and R. Saint. "Tissue-specific regulation of cyclin E transcription during Drosophila melanogaster embryogenesis." Development 127, no. 21 (2000): 4619–30. http://dx.doi.org/10.1242/dev.127.21.4619.

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Cyclin E is an essential regulator of S phase entry. We have previously shown that transcriptional regulation of the gene that encodes Drosophila cyclin E, DmcycE, plays an important role in the control of the G(1) to S phase transition during development. We report here the first comprehensive analysis of the transcriptional regulation of a G(1)phase cell cycle regulatory gene during embryogenesis. Analysis of deficiencies, a genomic transformant and reporter gene constructs revealed that DmcycE transcription is controlled by a large and complex cis-regulatory region containing tissue- and st

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43

Hagen, G., and T. J. Guilfoyle. "Rapid induction of selective transcription by auxins." Molecular and Cellular Biology 5, no. 6 (1985): 1197–203. http://dx.doi.org/10.1128/mcb.5.6.1197-1203.1985.

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Nuclei isolated from excised soybean plumules that were treated with 2,4-dichlorophenoxyacetic acid (2,4-D) were active in transcription of four auxin-regulated genes or DNA sequences, which have been described previously (G. Hagen, A. Kleinschmidt, and T. Guilfoyle, Planta 162:147-153, 1984). The rates of transcription of the auxin-responsive sequences were 10- to 100-fold greater with nuclei isolated from auxin-treated plumules than with those from untreated plumules. The transcriptional response was also observed with hypocotyls of intact soybean seedlings and hypocotyl sections, as well as

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44

Hagen, G., and T. J. Guilfoyle. "Rapid induction of selective transcription by auxins." Molecular and Cellular Biology 5, no. 6 (1985): 1197–203. http://dx.doi.org/10.1128/mcb.5.6.1197.

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Nuclei isolated from excised soybean plumules that were treated with 2,4-dichlorophenoxyacetic acid (2,4-D) were active in transcription of four auxin-regulated genes or DNA sequences, which have been described previously (G. Hagen, A. Kleinschmidt, and T. Guilfoyle, Planta 162:147-153, 1984). The rates of transcription of the auxin-responsive sequences were 10- to 100-fold greater with nuclei isolated from auxin-treated plumules than with those from untreated plumules. The transcriptional response was also observed with hypocotyls of intact soybean seedlings and hypocotyl sections, as well as

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Sui, Zhiyuan, Yongjie Zhang, Zhishuai Zhang, et al. "Analysis of Lin28B Promoter Activity and Screening of Related Transcription Factors in Dolang Sheep." Genes 14, no. 5 (2023): 1049. http://dx.doi.org/10.3390/genes14051049.

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The Lin28B gene is involved in the initiation of puberty, but its regulatory mechanisms remain unclear. Therefore, in this study, we aimed to study the regulatory mechanism of the Lin28B promoter by cloning the Lin28B proximal promoter for bioinformatic analysis. Next, a series of deletion vectors were constructed based on the bioinformatic analysis results for dual-fluorescein activity detection. The transcriptional regulation mechanism of the Lin28B promoter region was analyzed by detecting mutations in transcription factor-binding sites and overexpression of transcription factors. The dual-

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Thiel, Gerald, and Oliver G. Rössler. "TRPM3-Induced Gene Transcription Is under Epigenetic Control." Pharmaceuticals 15, no. 7 (2022): 846. http://dx.doi.org/10.3390/ph15070846.

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Transient receptor potential M3 (TRPM3) cation channels regulate numerous biological functions, including gene transcription. Stimulation of TRPM3 channels with pregnenolone sulfate activates stimulus-responsive transcription factors, which bind to short cognate sequences in the promoters of their target genes. In addition, coregulator proteins are involved that convert the chromatin into a configuration that is permissive for gene transcription. In this study, we determined whether TRPM3-induced gene transcription requires coactivators that change the acetylation pattern of histones. We used

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Tellier, Michael, Gilbert Ansa, and Shona Murphy. "Isoginkgetin and Madrasin are poor splicing inhibitors." PLOS ONE 19, no. 10 (2024): e0310519. http://dx.doi.org/10.1371/journal.pone.0310519.

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The production of eukaryotic mRNAs requires transcription by RNA polymerase (pol) II and co-transcriptional processing, including capping, splicing, and cleavage and polyadenylation. Pol II can positively affect co-transcriptional processing through interaction of factors with its carboxyl terminal domain (CTD), comprising 52 repeats of the heptapeptide Tyr1-Ser2-Pro3-Thr4-Ser5-Pro6-Ser7, and pol II elongation rate can regulate splicing. Splicing, in turn, can also affect transcriptional activity and transcription elongation defects are caused by some splicing inhibitors. Multiple small molecu

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Therizols, Pierre, Robert S. Illingworth, Celine Courilleau, Shelagh Boyle, Andrew J. Wood, and Wendy A. Bickmore. "Chromatin decondensation is sufficient to alter nuclear organization in embryonic stem cells." Science 346, no. 6214 (2014): 1238–42. http://dx.doi.org/10.1126/science.1259587.

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During differentiation, thousands of genes are repositioned toward or away from the nuclear envelope. These movements correlate with changes in transcription and replication timing. Using synthetic (TALE) transcription factors, we found that transcriptional activation of endogenous genes by a viral trans-activator is sufficient to induce gene repositioning toward the nuclear interior in embryonic stem cells. However, gene relocation was also induced by recruitment of an acidic peptide that decondenses chromatin without affecting transcription, indicating that nuclear reorganization is driven b

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Wood, David M., Renwick C. J. Dobson, and Christopher R. Horne. "Using cryo-EM to uncover mechanisms of bacterial transcriptional regulation." Biochemical Society Transactions 49, no. 6 (2021): 2711–26. http://dx.doi.org/10.1042/bst20210674.

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Transcription is the principal control point for bacterial gene expression, and it enables a global cellular response to an intracellular or environmental trigger. Transcriptional regulation is orchestrated by transcription factors, which activate or repress transcription of target genes by modulating the activity of RNA polymerase. Dissecting the nature and precise choreography of these interactions is essential for developing a molecular understanding of transcriptional regulation. While the contribution of X-ray crystallography has been invaluable, the ‘resolution revolution’ of cryo-electr

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Pérez-Schindler, Joaquín, Bastian Kohl, Konstantin Schneider-Heieck та ін. "RNA-bound PGC-1α controls gene expression in liquid-like nuclear condensates". Proceedings of the National Academy of Sciences 118, № 36 (2021): e2105951118. http://dx.doi.org/10.1073/pnas.2105951118.

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Plasticity of cells, tissues, and organs is controlled by the coordinated transcription of biological programs. However, the mechanisms orchestrating such context-specific transcriptional networks mediated by the dynamic interplay of transcription factors and coregulators are poorly understood. The peroxisome proliferator–activated receptor γ coactivator 1α (PGC-1α) is a prototypical master regulator of adaptive transcription in various cell types. We now uncovered a central function of the C-terminal domain of PGC-1α to bind RNAs and assemble multiprotein complexes including proteins that con

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