Relevant bibliographies by topics / Transcriptional enhancer

Contents

  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Transcriptional enhancer'

Author: Grafiati
Published: 3 June 2025
Last updated: 19 July 2025

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Journal articles on the topic "Transcriptional enhancer"

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Su, Guangsong, Wenbin Wang, Xueyuan Zhao, et al. "Enhancer architecture-dependent multilayered transcriptional regulation orchestrates RA signaling-induced early lineage differentiation of ESCs." Nucleic Acids Research 49, no. 20 (2021): 11575–95. http://dx.doi.org/10.1093/nar/gkab1001.

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Abstract Signaling pathway-driven target gene transcription is critical for fate determination of embryonic stem cells (ESCs), but enhancer-dependent transcriptional regulation in these processes remains poorly understood. Here, we report enhancer architecture-dependent multilayered transcriptional regulation at the Halr1–Hoxa1 locus that orchestrates retinoic acid (RA) signaling-induced early lineage differentiation of ESCs. We show that both homeobox A1 (Hoxa1) and Hoxa adjacent long non-coding RNA 1 (Halr1) are identified as direct downstream targets of RA signaling and regulated by RARA/RX
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Liu, Jing, Sharon Ochs та Courtney Sulentic. "Transcriptional regulation by 2,3,7,8-tetrachlorodibenzo-ρ-dioxin within the human polymorphic hs1,2 enhancer (42.7)". Journal of Immunology 188, № 1_Supplement (2012): 42.7. http://dx.doi.org/10.4049/jimmunol.188.supp.42.7.

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Abstract The environmental contaminant 2,3,7,8-tetrachlorodibenzo-ρ-dioxin (TCDD) inhibits Ig expression and secretion. Within the IgH gene, the 3’IgH regulatory region (3’IgHRR) has been identified as a transcriptional target of TCDD. TCDD inhibits mouse 3’IgHRR and induces aryl hydrocarbon receptor (AhR) binding to dioxin response elements (DREs) within the hs1,2 and hs4 enhancers. The human hs1,2 enhancer is polymorphic due to the presence of one to four invariant sequences (IS) which have been correlated with several autoimmune disorders. Interestingly, TCDD inhibits the transcriptional ac
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Yi, Mei, Yixin Tan, Li Wang, et al. "TP63 links chromatin remodeling and enhancer reprogramming to epidermal differentiation and squamous cell carcinoma development." Cellular and Molecular Life Sciences 77, no. 21 (2020): 4325–46. http://dx.doi.org/10.1007/s00018-020-03539-2.

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Abstract Squamous cell carcinoma (SCC) is an aggressive malignancy that can originate from various organs. TP63 is a master regulator that plays an essential role in epidermal differentiation. It is also a lineage-dependent oncogene in SCC. ΔNp63α is the prominent isoform of TP63 expressed in epidermal cells and SCC, and overexpression promotes SCC development through a variety of mechanisms. Recently, ΔNp63α was highlighted to act as an epidermal-specific pioneer factor that binds closed chromatin and enhances chromatin accessibility at epidermal enhancers. ΔNp63α coordinates chromatin-remode
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Zuin, Jessica, Gregory Roth, Yinxiu Zhan, et al. "Nonlinear control of transcription through enhancer–promoter interactions." Nature 604, no. 7906 (2022): 571–77. http://dx.doi.org/10.1038/s41586-022-04570-y.

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AbstractChromosome structure in mammals is thought to regulate transcription by modulating three-dimensional interactions between enhancers and promoters, notably through CTCF-mediated loops and topologically associating domains (TADs)1–4. However, how chromosome interactions are actually translated into transcriptional outputs remains unclear. Here, to address this question, we use an assay to position an enhancer at large numbers of densely spaced chromosomal locations relative to a fixed promoter, and measure promoter output and interactions within a genomic region with minimal regulatory a
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Carullo, Nancy V. N., Robert A. Phillips III, Rhiana C. Simon, et al. "Enhancer RNAs predict enhancer–gene regulatory links and are critical for enhancer function in neuronal systems." Nucleic Acids Research 48, no. 17 (2020): 9550–70. http://dx.doi.org/10.1093/nar/gkaa671.

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Abstract Genomic enhancer elements regulate gene expression programs important for neuronal fate and function and are implicated in brain disease states. Enhancers undergo bidirectional transcription to generate non-coding enhancer RNAs (eRNAs). However, eRNA function remains controversial. Here, we combined Assay for Transposase-Accessible Chromatin using Sequencing (ATAC-Seq) and RNA-Seq datasets from three distinct neuronal culture systems in two activity states, enabling genome-wide enhancer identification and prediction of putative enhancer–gene pairs based on correlation of transcription
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Fletcher, Alvaro, Zeba Wunderlich, and German Enciso. "Shadow enhancers mediate trade-offs between transcriptional noise and fidelity." PLOS Computational Biology 19, no. 5 (2023): e1011071. http://dx.doi.org/10.1371/journal.pcbi.1011071.

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Enhancers are stretches of regulatory DNA that bind transcription factors (TFs) and regulate the expression of a target gene. Shadow enhancers are two or more enhancers that regulate the same target gene in space and time and are associated with most animal developmental genes. These multi-enhancer systems can drive more consistent transcription than single enhancer systems. Nevertheless, it remains unclear why shadow enhancer TF binding sites are distributed across multiple enhancers rather than within a single large enhancer. Here, we use a computational approach to study systems with varyin
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Pauli, Sandra, Helen M. Rothnie, Gang Chen, Xiaoyuan He, and Thomas Hohn. "The Cauliflower Mosaic Virus 35S Promoter Extends into the Transcribed Region." Journal of Virology 78, no. 22 (2004): 12120–28. http://dx.doi.org/10.1128/jvi.78.22.12120-12128.2004.

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ABSTRACT A 60-nucleotide region (S1) downstream of the transcription start site of the cauliflower mosaic virus 35S RNA can enhance gene expression. By using transient expression assays with plant protoplasts, this activity was shown to be at least partially due to the effect of transcriptional enhancers within this region. We identify sequence motifs with enhancer function, which are normally masked by the powerful upstream enhancers of the 35S promoter. A repeated CT-rich motif is involved both in enhancer function and in interaction with plant nuclear proteins. The S1 region can also enhanc
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Li, Guowang, Yuxiang Kang, Xiangling Feng, et al. "Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells." Life Science Alliance 6, no. 6 (2023): e202201854. http://dx.doi.org/10.26508/lsa.202201854.

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Inflammatory cascade and extracellular matrix remodeling have been identified as pivotal pathological factors in the progression of intervertebral disc degeneration (IDD), but the mechanisms underlying the aberrant activation of transcription during nucleus pulposus (NP) cell degeneration remain elusive. Super-enhancers (SEs) are large clusters of adjacent lone enhancers, which control expression modes of cellular fate and pathogenic genes. Here, we showed that SEs underwent tremendous remodeling during NP cell degeneration and that SE-related transcripts were most abundant in inflammatory cas
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Ibragimov, Airat N., Oleg V. Bylino, and Yulii V. Shidlovskii. "Molecular Basis of the Function of Transcriptional Enhancers." Cells 9, no. 7 (2020): 1620. http://dx.doi.org/10.3390/cells9071620.

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Transcriptional enhancers are major genomic elements that control gene activity in eukaryotes. Recent studies provided deeper insight into the temporal and spatial organization of transcription in the nucleus, the role of non-coding RNAs in the process, and the epigenetic control of gene expression. Thus, multiple molecular details of enhancer functioning were revealed. Here, we describe the recent data and models of molecular organization of enhancer-driven transcription.
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Banditt, Michael, Theo Koller, and José M. Sogo. "Transcriptional Activity and Chromatin Structure of Enhancer-Deleted rRNA Genes in Saccharomyces cerevisiae." Molecular and Cellular Biology 19, no. 7 (1999): 4953–60. http://dx.doi.org/10.1128/mcb.19.7.4953.

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ABSTRACT We used the psoralen gel retardation assay and Northern blot analysis in an in vivo yeast system to analyze effects of rDNA enhancer deletions on the chromatin structure and the transcription of tagged rDNA units. We found that upon deletion of a single enhancer element, transcription of the upstream and downstream rRNA gene was reduced by about 50%. Although removing both flanking enhancers of an rRNA gene led to a further reduction in transcription levels, a significant amount of transcriptional activity remained, either resulting from the influence of more distantly located enhance
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Dissertations / Theses on the topic "Transcriptional enhancer"

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Koch, Frédéric. "From enhancer transcription to initiation and elongation : a study of eukaryotic transcriptional regulation during lymphocyte development." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22097.

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La régulation transcriptionnelle des eucaryotes supérieurs est un processus hautement contrôlé du point de vue spatial et temporel lors du développement, ou en réaction à l’environnement. La transcription ciblée des gènes codant requiert l’assemblage d’un complexe de pré-initiation (PIC) aux promoteurs comprenant l’ARN Polymérase (Pol) II et les facteurs généraux de transcription (GTFs) et dépend de la médiation d’un signal par les facteurs activateurs de transcription (TFs). Les années récentes ont montré que la transition de l’initiation vers l’élongation productive de la transcription repré
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Ho, Desiree Shulin. "Transcriptional regulation of the human CD30 gene through an intronic enhancer." University of Western Australia. Biochemistry and Molecular Biology Discipline Group, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0026.

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Lymphomas are neoplasms of the human immune system and can be divided into two categories, Hodgkin’s lymphoma (HL) and non-Hodgkin lymphoma (NHL). Anaplastic large cell lymphoma (ALCL) is a form of NHL that shares a common distinctive feature with HL, the overexpression CD30. The expression of cytokine receptor CD30 is restricted to proliferating B and T lymphocytes in healthy individuals while its overexpression is associated with several lymphoproliferative diseases such as ALCL and HL. The activation of CD30 via ligand or antibodies triggers various cellular responses ranging from apoptosis
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Amoretti, Villa Rocio. "Transcriptional regulation of the IgH locus during class switch recombination." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ078.

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La commutation isotypique (CI) des immunoglobulines (Ig) a lieu au locus constant de la chaîne lourde (IgH) de l'immunoglobuline lors de l'activation des cellules B et entraîne un changement de l'isotype exprimé. La CSR est déclenchée par l’enzyme AID et dépend des boucles à longue portée entre enhancers et promoteurs et de la transcription non-codante, qui sont contrôlés par l’enhancer Eμ et le super-enhancer de la région régulatrice 3' (3'RR). Ici, nous caractérisons le rôle sur la transcription non-codante et la CI de g1E, une région située en aval du gène Cg1 qui porte de marques d'enhance
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Yin, Shiyi. "Transcriptional Regulation of CFTR in the Intestinal Epithelium." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625503766675073.

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Chandra, Tanya. "Hairy enhancer of split 6 (Hes6) mediated transcriptional repression : mechanisms and targets." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29421.

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The Hairy enhancer of split 6 (Hes6) protein modulates myogenesis and neurogenesis by repressing inhibitors of differentiation. We demonstrate that Hes6 dependent transcriptional repression in myoblasts is mediated by recruitment to the DNA N-box. Identification of putative targets of Hes6 was attempted by creating inducible clones. Alternately, a target was sought by comparing cells with constitutive Hes6 expression to wildtype cells using DNA microarray technology. Candidate gene analysis of microarray data resulted in the identification of a novel potential target, cardiac helix-loop-helix
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FU, DECHEN. "THE STUDY OF MULTIPLE MECHANISMS THAT REGULATE THE TRANSCRIPTIONAL ACTIVITY OF BICOID." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100790435.

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Becker, Philipp Werner. "Transcriptional regulators of arterial-specific endothelial and mural cell development." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:01ac5c84-2e3b-4401-82ec-32331079e784.

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The vertebrate vasculature is formed by populations of endothelial and mural cells that arrange into functionally and molecularly distinct arterial, venous and capillary beds. Although a number of signalling pathways and transcriptional regulators have been implicated in these processes of vascular differentiation, a clear picture of how arterial-specific gene regulation is achieved is yet to emerge. In this study I have investigated the transcriptional regulation of arterial identity from two different directions: characterisation of enhancers to identify the transcription factors that bind a
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Ritter, Deborah Irene. "Coding and Noncoding Regulatory Enhancers in Vertebrate Development." Thesis, Boston College, 2011. http://hdl.handle.net/2345/3721.

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Thesis advisor: Jeffrey H. Chuang<br>Gene regulation is perhaps least understood among vertebrate species, where cell differentiation, tissue-types and body-plans indicate a complexity in need of careful coordination to achieve such hierarchical design. Recent studies reveal the intricacy of vertebrate gene regulation through diverse events including transcriptional regulatory histone modifications and non-coding DNA [1-5]. Almost 98% of the human genome is noncoding DNA, much of which may be actively involved in regulating healthy and disease-state gene expression and environmental response [
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He, Bing. "Systematic analysis of enhancer and promoter interactions." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1972.

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Transcriptional enhancers represent the primary basis for differential gene expression. These elements regulate cell type specificity, development, and evolution, with many human diseases resulting from altered enhancer activity. To date, a key gap in our knowledge is how enhancers select specific promoters for activation. To fill this gap, in this thesis, I first developed an Integrated Method for Predicting Enhancer Targets (IM-PET). Leveraging abundant “omics” data, I devised and characterized multiple genomic features for distinguishing true enhancer-promoter (EP) pairs from non-interactin
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Cassel, Tobias. "Transcriptional regulation of differentiation markers in the distal lung epithelium : a role for C/EBP factors /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4853-4/.

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Books on the topic "Transcriptional enhancer"

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Schnell, Stephanie A. Therapeutic targeting of Hairy and Enhancer of Split 1 (HES1) transcriptional programs in T-cell Acute Lymphoblastic Leukemia. [publisher not identified], 2015.

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Azmi, Peter B. Bacterially-derived DNA elements from the gene GPT can block enhancer-dependent transcriptional activation of an adjacent gene in a position-dependent manner. National Library of Canada, 2002.

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Zürich, Universität, ed. Functional analyses of transcriptional enhancers. [s.n.], 1985.

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Bieliauskaite, Egle. DNA binding properties of MADS-box transcription factor Myocyte Enhancer Factor 2C (MEF-2C). University of Birmingham, 2003.

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Banditt, Michael R. Transcriptional activity and chromatin structure of enhancer-deleted rRNA genes in S. cerevisiae. 1998.

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Characterization of enhancer-like sequences involved in the regulation of glnA in Escherichia coli. 1986.

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Wegner, Michael. Transcription Factors in Myelinating Cells. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199794591.003.0043.

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This is a digitally enhanced text. Readers can also see the coverage of this topic area in the second edition of Neuroglia. The second edition of Neuroglia was first published digitally in Oxford Scholarship Online and the bibliographic details provided, if cited, will direct people to that version of the text. Readers can also see the coverage of this topic area in the ...
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McFarland, Daniel C., and Jimmie Holland. Depression and Cancer. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780190603342.003.0006.

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The relationship between depression and cancer has long captured the imagination of clinicians and the lay population. Therefore, the science behind this putative relationship is paramount to determine reality from myth. This chapter begins with a historical and relevant clinical overview from within the context of psycho-oncology and psychoneuroimmunology. An exploration of the association between cancer and depression follows by reviewing cancer initiation and progression data in the context of depression. Biological correlates of the stress response in depression, inflammation, and its effe
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Raju, Raghavan, and Irshad H. Chaudry. The host response to hypoxia in the critically ill. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199600830.003.0305.

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The hypoxic response of the host is complex. While the oxygen-sensing intracellular machinery attempts to restore cellular homeostasis by augmenting respiration and blood flow, events such as severe haemorrhage lead to whole body hypoxia and decreased mitochondrial function. Immunological perturbations following severe haemorrhage may result in multiple organ dysfunction and sepsis, while impaired perfusion may lead to microvascular injury and local hypoxia. Trauma-haemorrhage or hypoxic exposure in animals causes a systemic inflammatory response, decreased antigen presentation by peritoneal m
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Baobaid, Mohammed, Lynda Ashbourne, Abdallah Badahdah, and Abir Al Jamal. Home / Publications / Pre and Post Migration Stressors and Marital Relations among Arab Refugee Families in Canada Pre and Post Migration Stressors and Marital Relations among Arab Refugee Families in Canada. 2nd ed. Hamad Bin Khalifa University Press, 2019. http://dx.doi.org/10.5339/difi_9789927137983.

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The study is funded by Doha International Family Institute (DIFI), a member of Qatar Foundation, and is a collaboration between the Muslim Resource Centre for Social Support and Integration of London, Ontario; University of Guelph, Ontario; and University of Calgary, Alberta, all located in Canada; and the Doha International Family Institute, Qatar. The study received research ethics approval from the University of Guelph and the University of Calgary. This study aims to assess the impact of pre- and post-migration on marital relationships and family dynamics for Arab refugee families resettle
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Book chapters on the topic "Transcriptional enhancer"

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Kraus, Petra, Cecilia L. Winata, and Thomas Lufkin. "BAC Transgenic Zebrafish for Transcriptional Promoter and Enhancer Studies." In Methods in Molecular Biology. Springer New York, 2014. http://dx.doi.org/10.1007/978-1-4939-1652-8_12.

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Lin, Yuan, and Jiming Jiang. "Rapid Validation of Transcriptional Enhancers Using a Transient Reporter Assay." In Modeling Transcriptional Regulation. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1534-8_16.

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Chambon, P. "Nuclear Receptors as Transcriptional Enhancers." In Molecular and Cell Biology of Autoantibodies and Autoimmunity. Abstracts. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-46681-6_4.

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Bettenfeld, Vincent, Salima Mdhaffar, Christophe Choquet, and Claudine Piau-Toffolon. "Instrumentation of Classrooms Using Synchronous Speech Transcription." In Lifelong Technology-Enhanced Learning. Springer International Publishing, 2018. http://dx.doi.org/10.1007/978-3-319-98572-5_65.

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Gehrke, Lee, and Stephen A. Jobling. "Untranslated Leader Sequences and Enhanced Messenger RNA Translational Efficiency." In Post-Transcriptional Control of Gene Expression. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75139-4_36.

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Narayanan, Arthy, and Anne E. West. "Genome and Epigenome Engineering Approaches to Studying Neuronal Activity-Dependent Transcriptional Enhancers." In Transcriptional Regulation by Neuronal Activity. Springer Nature Switzerland, 2024. http://dx.doi.org/10.1007/978-3-031-68550-7_7.

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Jasnovidova, Olga, Mirjam Arnold, and Andreas Mayer. "Illuminating Enhancer Transcription at Nucleotide Resolution with." In Methods in Molecular Biology. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1597-3_3.

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Bourachot, Brigitte, Philippe Herbomel, and Moshe Yaniv. "Transcription Control in Eucaryotes-Enhancers and Promoters." In Cell Transformation. Springer US, 1985. http://dx.doi.org/10.1007/978-1-4684-5009-5_16.

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Loft, Anne, Maja Worm Andersen, Jesper Grud Skat Madsen, and Susanne Mandrup. "Analysis of Enhancers and Transcriptional Networks in Thermogenic Adipocytes." In Methods in Molecular Biology. Springer US, 2022. http://dx.doi.org/10.1007/978-1-0716-2087-8_11.

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Gonçalves, João, Helena Soares, Norman L. Eberhardt, et al. "TFE3/Transcription Factor Binding to IGHM Enhancer 3 (AGS11)." In Encyclopedia of Signaling Molecules. Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0461-4_101353.

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Conference papers on the topic "Transcriptional enhancer"

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Chang, Sungkyun, Emmanouil Benetos, Holger Kirchhoff, and Simon Dixon. "YourMT3+: Multi-Instrument Music Transcription with Enhanced Transformer Architectures and Cross-Dataset STEM Augmentation." In 2024 IEEE 34th International Workshop on Machine Learning for Signal Processing (MLSP). IEEE, 2024. http://dx.doi.org/10.1109/mlsp58920.2024.10734819.

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George, Rani E. "Abstract CN08-04: Targeting super-enhancer driven transcriptional dependencies in cancer." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-cn08-04.

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Wing Cheung, Otto Ka, Feng Wu, Sau-Dan Lee, et al. "IDDF2018-ABS-0153 Super-enhancer-associated master transcriptional circuitry in nafld-hcc development." In International Digestive Disease Forum (IDDF) 2018, Best Abstracts, Hong Kong, 9–10 June 2018. BMJ Publishing Group Ltd and British Society of Gastroenterology, 2018. http://dx.doi.org/10.1136/gutjnl-2018-iddfbestabstracts.7.

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Duffus, K., M. Imran, T. Katopodi, et al. "OP0288 Transcriptional perturbation of ra-risk enhancer by crispr-deadcas9 regulates long range gene targets." In Annual European Congress of Rheumatology, EULAR 2018, Amsterdam, 13–16 June 2018. BMJ Publishing Group Ltd and European League Against Rheumatism, 2018. http://dx.doi.org/10.1136/annrheumdis-2018-eular.3946.

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Lee, Ye Sol, Wontak Kim, Katherine K. Soh, et al. "Abstract C202: CDK9 inhibition synergizes with BRD4 inhibitor-mediated super enhancer transcriptional repression in multiple preclinical tumor models." In Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; November 5-9, 2015; Boston, MA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1535-7163.targ-15-c202.

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Bahr, Brigham L., Kyle S. Maughan, Katherine K. Soh, et al. "Abstract 2698: Combination strategies to target super enhancer transcriptional activity by CDK9 and BRD4 inhibition in acute myeloid leukemia." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-2698.

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Hsu, Cheng-Lung, Hsin-Pai Li, Yung-Chia Kuo, Ngan-Ming Tsang, and Yu-Sun Chang. "Abstract 1020: Latent membrane protein 1 N-C interaction of EBV facilitates (nuclear factor kappa-light-chain-enhancer of activated B cells transcriptional activity." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-1020.

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Gonçalves, Yanna Torres, João Victor B. Alves, Breno Alef Dourado Sá, Lázaro Natanael da Silva, José A. Fernandes de Macedo, and Ticiana L. Coelho da Silva. "Speech Recognition Models in Assisting Medical History." In Simpósio Brasileiro de Banco de Dados. Sociedade Brasileira de Computação - SBC, 2024. http://dx.doi.org/10.5753/sbbd.2024.240270.

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This paper addresses challenges highlighted by health professionals, where up to 50\% of a medical consultation's time is spent on history creation. To streamline this process, we propose leveraging Automatic Speech Recognition (ASR) models to convert spoken language into text. In our study, we assess the effectiveness of pre-trained ASR models for medical history transcription in Brazilian Portuguese. By incorporating language models to enhance ASR output, we aim to improve the accuracy and semantic fidelity of transcriptions. Our results demonstrate that integrating a 5-gram model with Wav2V
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Gonçalves, Yanna Torres, João Victor B. Alves, Breno Alef Dourado Sá, Lázaro Natanael da Silva, José A. Fernandes de Macedo, and Ticiana L. Coelho da Silva. "MedTalkAI: Assisted Anamnesis Creation With Automatic Speech Recognition." In Anais Estendidos do Simpósio Brasileiro de Banco de Dados. Sociedade Brasileira de Computação - SBC, 2024. http://dx.doi.org/10.5753/sbbd_estendido.2024.243214.

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Conventional approaches to documenting patient medical histories are often time-consuming and require significant healthcare professional involvement. This paper introduces MedTalkAI, which integrates ASR models, including Whisper and Wav2Vec 2.0, to transcribe audio recordings of patient histories in Brazilian Portuguese efficiently. MedTalkAI validates, corrects, and evaluates transcriptions, facilitating the creation of a unique medical audio-text database. Additionally, MedTalkAI enhances ASR models for medical applications using language models. This approach aims to improve medical histo
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Tang, Yixuan, and Anthony K. H. Tung. "Contextualized Speech Recognition: Rethinking Second-Pass Rescoring with Generative Large Language Models." In Thirty-Third International Joint Conference on Artificial Intelligence {IJCAI-24}. International Joint Conferences on Artificial Intelligence Organization, 2024. http://dx.doi.org/10.24963/ijcai.2024/716.

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Automatic Speech Recognition (ASR) systems have witnessed notable advancements in recent years. Contextualized ASR tasks require recognizing speech not as isolated utterances but within the broader context in which they occur. Conventional approaches often employ a second-pass paradigm to re-rank initial transcriptions, yet they risk propagating errors across candidate hypotheses, thereby compromising recognition precision. In this study, we introduce a novel framework that diverges from typical second-pass rescoring methods. Given n-best hypotheses, we leverage prompting with a large language
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Reports on the topic "Transcriptional enhancer"

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G. GUPTA and C. TUNG. PREDICTIVE MODELS FOR TRANSCRIPTIONAL ENHANCERS. Office of Scientific and Technical Information (OSTI), 2000. http://dx.doi.org/10.2172/769080.

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Coplin, David, Isaac Barash, and Shulamit Manulis. Role of Proteins Secreted by the Hrp-Pathways of Erwinia stewartii and E. herbicola pv. gypsophilae in Eliciting Water-Soaking Symptoms and Initiating Galls. United States Department of Agriculture, 2001. http://dx.doi.org/10.32747/2001.7580675.bard.

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Many bacterial pathogens of plants can inject pathogenicity proteins into host cells using a specialized type III secretion system encoded by hrpgenes. This system deliver effector proteins, into plant cells that function in both susceptible and resistant interactions. We have found that the virulence of Erwinia stewartii(Es; syn. Pantoea stewartii) and Erwinia herbicola pv. gypsophilae (Ehg, syn. Pantoea agglomerans), which cause Stewart's wilt of corn and galls on Gypsophila, respectively, depends on hrpgenes. The major objectives of this project were: To increase expression of hrpgenes in o
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Fromm, Hillel, Paul Michael Hasegawa, and Aaron Fait. Calcium-regulated Transcription Factors Mediating Carbon Metabolism in Response to Drought. United States Department of Agriculture, 2013. http://dx.doi.org/10.32747/2013.7699847.bard.

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Original objectives: The long-term goal of the proposed research is to elucidate the transcription factors, genes and metabolic networks involved in carbon metabolism and partitioning in response to water deficit. The proposed research focuses on the GTLcalcium/calmodulinbindingTFs and the gene and metabolic networks modulated by these TFs in Arabidopsis thaliana. The specific objectives are as follows. Objective-1 (USA): Physiological analyses of GTL1 loss- and gain-of-function plants under water sufficient and drought stress conditions Objective 2 (USA / Israel-TAU): Characterizion of GTL ta
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Fromm, A., Avihai Danon, and Jian-Kang Zhu. Genes Controlling Calcium-Enhanced Tolerance to Salinity in Plants. United States Department of Agriculture, 2003. http://dx.doi.org/10.32747/2003.7585201.bard.

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The specific objectives of the proposed research were to identify, clone and characterize downstream cellular target(s) of SOS3 in Arabidopsis thaliana, to analyze the Ca2+-binding characteristics of SOS3 and the sos3-1 mutant and their interactions with SOS3 cellular targets to analyze the SOS3 cell-specific expression patterns, and its subcellular localization, and to assess the in vivo role of SOS3 target protein(s) in plant tolerance to salinity stress. In the course of the study, in view of recent opportunities in identifying Ca2+ - responsive genes using microarrays, the group at Weizman
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Whitham, Steven A., Amit Gal-On, and Victor Gaba. Post-transcriptional Regulation of Host Genes Involved with Symptom Expression in Potyviral Infections. United States Department of Agriculture, 2012. http://dx.doi.org/10.32747/2012.7593391.bard.

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Understanding how RNA viruses cause disease symptoms in their hosts is expected to provide information that can be exploited to enhance modern agriculture. The helper component-proteinase (HC-Pro) protein of potyviruses has been implicated in symptom development. Previously, we demonstrated that symptom expression is associated with binding of duplex small-interfering-RNA (duplex-siRNA) to a highly conserved FRNK amino acid motif in the HC-Pro of Zucchini yellow mosaic virus (ZYMV). This binding activity also alters host microRNA (miRNA) profiles. In Turnip mosaic virus (TuMV), which infects t
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Griffiths, Rachael. Transkribus in Practice: Improving CER. Verlag der Österreichischen Akademie der Wissenschaften, 2022. http://dx.doi.org/10.1553/tibschol_erc_cog_101001002_griffiths_cer.

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This paper documents ongoing efforts to enhance the accuracy of Handwritten Text Recognition (HTR) models using Transkribus, focusing on the transcription of Tibetan cursive (dbu med) manuscripts from the 11th to 13th centuries within the framework of the ERC-funded project, The Dawn of Tibetan Buddhist Scholasticism (11th-13th C.) (TibSchol). It presents the steps taken to improve the Character Error Rate (CER) of the HTR models, the results achieved so far, and considerations for those working on similar projects.
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Chrivia, John C. Chromatin Regulation of Estrogen-Mediated Transcription in Breast Cancer: Rules for Binding Sites in Nucleosomes and Modified Histones that Enhance ER Binding. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada443200.

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Porat, Ron, Gregory T. McCollum, Amnon Lers, and Charles L. Guy. Identification and characterization of genes involved in the acquisition of chilling tolerance in citrus fruit. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7587727.bard.

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Citrus, like many other tropical and subtropical fruit are sensitive to chilling temperatures. However, application of a pre-storage temperature conditioning (CD) treatment at 16°C for 7 d or of a hot water brushing (HWB) treatment at 60°C for 20 sec remarkably enhances chilling tolerance and reduces the development of chilling injuries (CI) upon storage at 5°C. In the current research, we proposed to identify and characterize grapefruit genes that are induced by CD, and may contribute to the acquisition of fruit chilling tolerance, by two different molecular approaches: cDNA array analysis an
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Dubcovsky, Jorge, Tzion Fahima, Ann Blechl, and Phillip San Miguel. Validation of a candidate gene for increased grain protein content in wheat. United States Department of Agriculture, 2007. http://dx.doi.org/10.32747/2007.7695857.bard.

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High Grain Protein Content (GPC) of wheat is important for improved nutritional value and industrial quality. However, selection for this trait is limited by our poor understanding of the genes involved in the accumulation of protein in the grain. A gene with a large effect on GPC was detected on the short arm of chromosome 6B in a Triticum turgidum ssp. dicoccoides accession from Israel (DIC, hereafter). During the previous BARD project we constructed a half-million clones Bacterial Artificial Chromosome (BAC) library of tetraploid wheat including the high GPC allele from DIC and mapped the G
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Bennett, Alan, and Arthur Schaffer. Sucrose Metabolism in Developing Fruit of Wild and Cultivated Lycopersicon Species. United States Department of Agriculture, 1996. http://dx.doi.org/10.32747/1996.7613009.bard.

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The project focused on a strategy to enhance tomato fruit soluble solids by evaluating components of carbohydrate metabolism in fruit of wild tomato species that accumulate sucrose rather than hexose and have extremely high soluble sugar contents. The overall goal was to determine the extent to which sucrose accumulation contributes to elevated soluble solids levels and to understand the underlying genetic and biochemical basis of the trait. The research objectives were to evaluate near isogenic L. esculentum lines segregating for sucrose- and hexose-accumulation, determine the biochemical bas
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