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Dissertations / Theses on the topic 'Transcriptional enhancer'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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1

Koch, Frédéric. "From enhancer transcription to initiation and elongation : a study of eukaryotic transcriptional regulation during lymphocyte development." Thesis, Aix-Marseille 2, 2011. http://www.theses.fr/2011AIX22097.

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La régulation transcriptionnelle des eucaryotes supérieurs est un processus hautement contrôlé du point de vue spatial et temporel lors du développement, ou en réaction à l’environnement. La transcription ciblée des gènes codant requiert l’assemblage d’un complexe de pré-initiation (PIC) aux promoteurs comprenant l’ARN Polymérase (Pol) II et les facteurs généraux de transcription (GTFs) et dépend de la médiation d’un signal par les facteurs activateurs de transcription (TFs). Les années récentes ont montré que la transition de l’initiation vers l’élongation productive de la transcription repré
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2

Ho, Desiree Shulin. "Transcriptional regulation of the human CD30 gene through an intronic enhancer." University of Western Australia. Biochemistry and Molecular Biology Discipline Group, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0026.

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Lymphomas are neoplasms of the human immune system and can be divided into two categories, Hodgkin’s lymphoma (HL) and non-Hodgkin lymphoma (NHL). Anaplastic large cell lymphoma (ALCL) is a form of NHL that shares a common distinctive feature with HL, the overexpression CD30. The expression of cytokine receptor CD30 is restricted to proliferating B and T lymphocytes in healthy individuals while its overexpression is associated with several lymphoproliferative diseases such as ALCL and HL. The activation of CD30 via ligand or antibodies triggers various cellular responses ranging from apoptosis
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3

Amoretti, Villa Rocio. "Transcriptional regulation of the IgH locus during class switch recombination." Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAJ078.

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La commutation isotypique (CI) des immunoglobulines (Ig) a lieu au locus constant de la chaîne lourde (IgH) de l'immunoglobuline lors de l'activation des cellules B et entraîne un changement de l'isotype exprimé. La CSR est déclenchée par l’enzyme AID et dépend des boucles à longue portée entre enhancers et promoteurs et de la transcription non-codante, qui sont contrôlés par l’enhancer Eμ et le super-enhancer de la région régulatrice 3' (3'RR). Ici, nous caractérisons le rôle sur la transcription non-codante et la CI de g1E, une région située en aval du gène Cg1 qui porte de marques d'enhance
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4

Yin, Shiyi. "Transcriptional Regulation of CFTR in the Intestinal Epithelium." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1625503766675073.

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5

Chandra, Tanya. "Hairy enhancer of split 6 (Hes6) mediated transcriptional repression : mechanisms and targets." Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=29421.

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The Hairy enhancer of split 6 (Hes6) protein modulates myogenesis and neurogenesis by repressing inhibitors of differentiation. We demonstrate that Hes6 dependent transcriptional repression in myoblasts is mediated by recruitment to the DNA N-box. Identification of putative targets of Hes6 was attempted by creating inducible clones. Alternately, a target was sought by comparing cells with constitutive Hes6 expression to wildtype cells using DNA microarray technology. Candidate gene analysis of microarray data resulted in the identification of a novel potential target, cardiac helix-loop-helix
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6

FU, DECHEN. "THE STUDY OF MULTIPLE MECHANISMS THAT REGULATE THE TRANSCRIPTIONAL ACTIVITY OF BICOID." University of Cincinnati / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1100790435.

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7

Becker, Philipp Werner. "Transcriptional regulators of arterial-specific endothelial and mural cell development." Thesis, University of Oxford, 2015. http://ora.ox.ac.uk/objects/uuid:01ac5c84-2e3b-4401-82ec-32331079e784.

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The vertebrate vasculature is formed by populations of endothelial and mural cells that arrange into functionally and molecularly distinct arterial, venous and capillary beds. Although a number of signalling pathways and transcriptional regulators have been implicated in these processes of vascular differentiation, a clear picture of how arterial-specific gene regulation is achieved is yet to emerge. In this study I have investigated the transcriptional regulation of arterial identity from two different directions: characterisation of enhancers to identify the transcription factors that bind a
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8

Ritter, Deborah Irene. "Coding and Noncoding Regulatory Enhancers in Vertebrate Development." Thesis, Boston College, 2011. http://hdl.handle.net/2345/3721.

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Thesis advisor: Jeffrey H. Chuang<br>Gene regulation is perhaps least understood among vertebrate species, where cell differentiation, tissue-types and body-plans indicate a complexity in need of careful coordination to achieve such hierarchical design. Recent studies reveal the intricacy of vertebrate gene regulation through diverse events including transcriptional regulatory histone modifications and non-coding DNA [1-5]. Almost 98% of the human genome is noncoding DNA, much of which may be actively involved in regulating healthy and disease-state gene expression and environmental response [
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9

He, Bing. "Systematic analysis of enhancer and promoter interactions." Diss., University of Iowa, 2015. https://ir.uiowa.edu/etd/1972.

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Transcriptional enhancers represent the primary basis for differential gene expression. These elements regulate cell type specificity, development, and evolution, with many human diseases resulting from altered enhancer activity. To date, a key gap in our knowledge is how enhancers select specific promoters for activation. To fill this gap, in this thesis, I first developed an Integrated Method for Predicting Enhancer Targets (IM-PET). Leveraging abundant “omics” data, I devised and characterized multiple genomic features for distinguishing true enhancer-promoter (EP) pairs from non-interactin
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10

Cassel, Tobias. "Transcriptional regulation of differentiation markers in the distal lung epithelium : a role for C/EBP factors /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4853-4/.

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11

Stroebele, Elizabeth Kristine. "Identification and characterization of transcriptional enhancers integrating Notch and other developmental signals : regulation of the Drosophila nab locus." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3197.

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Cell signaling pathways are frequently used in multiple tissue and stage-specific contexts during multicellular development. The integration of these signaling pathways by transcriptional enhancers controls the tissue specific gene expression necessary for proper development. Enhancers are segments of DNA that interpret developmental signals to produce patterns of gene expression. A set of operational rules defines how different enhancers targeted by the same signals interpret and act on these signals. Using the Drosophila model system, my thesis work focuses on determining the operational rul
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12

Verdikt, Roxane. "Epigenetic and Transcriptional Mechanisms of Human Immunodeficiency Virus type 1 Persistence in T-lymphoid and Myeloid Reservoirs." Doctoral thesis, Universite Libre de Bruxelles, 2019. https://dipot.ulb.ac.be/dspace/bitstream/2013/287450/3/PhD.pdf.

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HIV-1 infections can be treated but not cured by the current antiretroviral therapy regimens. One of the major barriers to HIV-1 eradication is the persistence of the virus in treated HIV+ individuals under the form of reservoirs. A continuum of molecular mechanisms, at the epigenetic, transcriptional and post-transcriptional levels maintains HIV-1 gene expression silent in its reservoirs. A better understanding of HIV-1 molecular mechanisms of persistence thus allows to devise novel therapeutic approaches to eradicate the virus. In this context, our thesis aimed at characterizing the molecula
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13

Ruffell, Daniela A. "In vivo studies on the transcriptional and posttranslational regulation of the CCAAT, enhancer binding protein beta." [S.l. : s.n.], 2007. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-72602.

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14

Grégoire, Serge. "Distinct roles of histone deacetylases 3 and 4 in regulating the transcriptional activity of myocyte enhancer factor 2." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102503.

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The myocyte enhancer factor 2 (MEF2) family of transcription factors plays important roles during muscle differentiation as well as in different programs of non-muscle cells. Covalent modification has emerged as an important mechanism for regulating MEF2 function. The goal of my thesis project was to identify novel post-translational modifications that modulate MEF2 transcriptional activity and to determine whether histone deacetylases coordinate these modifications. I first demonstrated that MEF2D is modified by the ubiquitin-like protein SUMO. Sumoylation of MEF2D at a single residue, lysine
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15

Correia, Catarina Mendes. "Identification of transcriptional enhancers regulated by insulin signalling in mouse liver tissue." Master's thesis, Universidade de Aveiro, 2017. http://hdl.handle.net/10773/19147.

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Mestrado em Bioquímica - Bioquímica Clínica<br>A diabetes mellitus de tipo 2 (DMT2) afeta cerca de 8% da população adulta mundial, representando 90% de todos os casos de diabetes. Esta doença é causada por uma resposta diminuída à ação da insulina, levando a hiperglicemia e hiperinsulinemia compensatória, que resultam numa diminuição severa da qualidade e esperança de vida dos pacientes. Apesar de ter sido associada à dieta e estilo de vida como fatores de risco principais, foram já propostos fatores genéticos da doença, com crescente apoio científico. Para estudar os mecanismos da tra
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16

Chen, Chin. "Nutrient regulation of the human ccaat/enhancer-binding protein beta and its relation to transcriptional control of the human asparagine synthetase gene." [Gainesville, Fla.] : University of Florida, 2004. http://wwwlib.umi.com/cr/ufl/fullcit?p3136933.

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Thesis (Ph.D.)--University of Florida, 2004.<br>Typescript. Title from title page of source document. Document formatted into pages; contains 161 pages. Includes Vita. Includes bibliographical references.
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17

Roure, Agnes. "Mécanismes de régulations transcriptionnelles contrôlant la régionalisation de l'épiderme au cours du développement chez l'Ascidie Ciona intestinalis." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM4111.

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3 domaines cellulaires définissent l'épiderme de la queue de Ciona intestinalis. Le domaine des lignes médianes, donne naissance à deux structures différenciées larvaires, la nageoire et système nerveux périphérique. Il a été montré que les voies de signalisation BMP et FGF sont respectivement les inducteurs des lignes médianes ventrale et dorsale. Ce travail a consisté en la caractérisation des mécanismes moléculaires, situés à l'interface des signaux inducteurs et des processus de différenciation, définissant l'identité cellulaire des lignes médianes. L'identification des relations épistatiq
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18

Fabre-Suver, Christine Mireille Alice. "Role of the Trex control element and its binding factor in the transcriptional regulation of muscle genes during development /." Thesis, Connect to this title online; UW restricted, 1998. http://hdl.handle.net/1773/9265.

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19

O'Rourke, John P. "Expression, function and transcriptional regulation of the CCAAT/enhancer binding protein delta (C/EBP(delta)) in mouse mammary epithelial cells /." The Ohio State University, 1998. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487953567769952.

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20

Stepanik, Vincent A. "Characterization of the Aberrant Transcriptional Silencing Caused by the Trithorax mimic Allele of the Histone Methyltransferase Enhancer of zeste." Case Western Reserve University School of Graduate Studies / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=case1291225073.

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21

Gutierrez, Gallegos Soraya Elisa. "Mechanisms Contributing to Transcriptional Regulation and Chromatin Remodeling of the Bone Specific Osteocalcin Gene." eScholarship@UMMS, 2002. https://escholarship.umassmed.edu/gsbs_diss/12.

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Activation of tissue-specific genes is a tightly controlled process that normally involves the combined action of several transcription factors and transcriptional co-regulators. The bone-specific osteoca1cin gene (OC) has been used as a prototype to study both tissue-specific and hormonal responsiveness. In this study we have examined the role of Runx2, VDR and C/EBP factors in the regulation of OC gene transcription. Contributions of the Runx and VDRE motifs to OC promoter activity were addressed by introducing point mutations within the context of the rat (-1.1 kb) osteocalcin promoter fuse
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22

Chen, Changya. "Dynamics of epigenome and 3D genome in hematopoietic stem cell development." Diss., University of Iowa, 2017. https://ir.uiowa.edu/etd/5920.

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Hematopoietic stem cell (HSC) development is accompanied by dynamic changes in the transcriptional program. How the corresponding transcriptional programs are related to the epigenetic mechanism is poorly understood. To fill this gap, we first profiled the transcriptomes and epigenomes using RNA-Seq and ChIP-Seq for five key developmental stages of HSC emergence in the mouse embryo. Using epigenetic markers, we identified novel 12,000~17,000 enhancers for each developmental stage. We applied a computational tool to link those enhancers to their target genes. Systematical analysis of enhancer-p
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23

Salma, Nunciada. "Transcriptional Regulation During Adipocyte Differentiation: A Role for SWI/SNF Chromatin Remodeling Enzymes: A Dissertation." eScholarship@UMMS, 2006. https://escholarship.umassmed.edu/gsbs_diss/50.

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Chromatin has a compact organization in which most DNA sequences are structurally inaccessible and functionally inactive. Reconfiguration of thechromatir required to activate transcription. This reconfiguration is achieved by the action of enzymes that covalently modify nucleosomal core histones, and by enzymes that disrupt histone-DNA interactions via ATP hydrolysis. TheSWI/SNF family of ATP-dependent chromatin remodeling enzymes has been implicated not only in gene activation but also in numerous cellular processes including differentiation, gene repression, cell cycle control, recombination
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24

Hache, Antoine. "Molecular basis of transcriptional dysregulations in the spinocerebellar ataxia type 7, a neurodegenerative polyglutamine disorder." Thesis, Strasbourg, 2020. http://www.theses.fr/2020STRAJ083.

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SCA7 est une maladie génétique dont l’un des principaux symptômes est une perte progressive d’acuité visuelle pouvant aller jusqu’à la cécité. La mutation responsible de cette pathologie est une expansion instable d’un triplet CAG au sein de l’ATXN7, gene codant une sous-unité du complexe SAGA, un co-activateur de l’ARN polymerase de type II. Des études réalisées sur modèles de souris transgéniques mirent en évidence une perte d’identité des photorécepteurs au niveau morphologique, fonctionnel, et moléculaire. Au cours de ma thèse la caractérisation d’un nouveau modèle knock-in de SCA7 fut réa
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25

Koivisto, E. (Elina). "Characterization of signalling pathways in cardiac hypertrophic response." Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514294617.

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Abstract Intracellular signalling cascades regulate cardiomyocyte hypertrophic response. Initially hypertrophy of individual myocytes occurs as an adaptive response to increased demands for cardiac work, e.g. during hypertension or after myocardial infarction, but a prolonged hypertrophic response, accompanied by accelerated fibrosis and apoptosis, predisposes the heart to impaired performance and the syndrome of heart failure. The goal of this work was to elucidate some of the main signalling pathways in experimental models of the cardiac hypertrophic response. Mechanical stretching of cultur
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26

Hoermann, Astrid 1981. "A Systems-level study of giant regulation in Drosophila melanogaster." Doctoral thesis, Universitat Pompeu Fabra, 2014. http://hdl.handle.net/10803/286075.

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Esta tesis revela la regulación transcripcional del gen gap giant (gt) en el embrión blastodermal de Drosophila por ingeniería inversa: un modelo matemático infiere los mecanismos subyacentes de datos cuantitativos de expresión recopilados en un fondo genético silvestre. El modelo se amolda a mRNA reportero controlado por elementos reguladores en cis (CRE) de gt. Es una herramienta potente para investigar cómo se forma el patrón a nivel molecular por los sitios de unión de factores de transcripción y permite predecir la expresión en cepas mutantes. La presente tesis esclarece la regulación dif
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27

MARIANI, JESSICA. "Transcriptional regulation, target genes and functional roles of the SOX2 transcription factor in mouse neural stem cells maintenance and neuronal differentiation." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2009. http://hdl.handle.net/10281/8321.

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The aims of this PhD research were: to examine molecular mechanisms underlying the transcriptional regulation of the Sox2 gene during forebrain development; to examine the role of Sox2 for the proper neuronal differentiation of neural stem cells; and to examine the role of Sox2 in controlling the maintenance of neural stem cells (in vivo and in vitro). The aim of the first work (Chapter 1) was to investigate the transcription factors and the regulatory sequences that control transcription of the Sox2 gene in the developing brain and neural stem cells. Our laboratory previously identified Sox2
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28

Peltier, Agathe. "Rôle des facteurs de transcription PHOX2B, GATA3 et HAND2 dans l’identité et l’oncogenèse du neuroblastome." Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS509.

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Le neuroblastome est cancer du jeune enfant se développant au sein du système nerveux périphérique sympathique. Cette tumeur est caractérisée par sa grande hétérogénéité clinique : allant de formes régressant spontanément aux tumeurs de haut-risque, réfractaires aux traitements les plus agressifs. La survie à long terme des patients présentant un neuroblastome de haut-risque reste par ailleurs inférieure à 50%, ce qui souligne la nécessité de trouver de nouveaux traitements afin d’améliorer leur prise en charge thérapeutique.Récemment, en définissant le paysage épigénétique des cellules de neu
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29

Singapuri, Sonali Pradeepkumar. "Engineering Transcriptional Machinery for Enhanced Limonene Production in Cyanobacteria." Miami University / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=miami1564765898012989.

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30

Gueroult, bellone Marion. "Signatures nucléotidiques de l'activité des enhancers développementaux chez l'ascidie Ciona intestinalis." Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTS029.

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Les enhancers sont des régulateurs cruciaux de l’expression des gènes pendant le développement embryonnaire. L’ascidie Ciona intestinalis est un organisme-modèle qui se prête à l’étude de ces séquences cis-régulatrices car ses enhancers sont généralement petits et compacts, et le lignage invariant des cellules chez l’embryon permet de visualiser leur activité avec une résolution cellulaire. Deux signatures indépendantes associées à l’activité d’un enhancer avaient été identifiées : la présence de sites de fixation pour des facteurs de transcription spécifiques, et une signature dinucléotidique
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31

Williamson, William Iain. "Differential chromatin topology and transcription factor enhancer binding regulate spatiotemporal gene expression in limb development." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8056.

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Many developmental genes are located in gene-poor genomic regions and are activated by long-range enhancers located up to 1Mb away. Modification and reorganisation of chromatin structure is pivotal to such long-range gene regulation. A prerequisite for enhancer activity is the binding of transcription factors and co-factors with the interplay between activating and repressive factors determining tissue, spatial and temporal specificity. Spatiotemporal control of sonic hedgehog (Shh) and the 5′ Hoxd genes (especially Hoxd13) is crucial for vertebrate limb anterior-posterior (A-P) axis and autop
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32

Galle, Courtney Searcey. "Characterization of Cis-acting partners within the cytomegalovirus major immediate-early enhancer that strengthen MIE gene expression and viral fitness." Diss., University of Iowa, 2013. https://ir.uiowa.edu/etd/4985.

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Human cytomegalovirus infects approximately 50% of adults in the United States and in most cases is asymptomatic. However, in the case of immune compromised persons such as AIDS patients, transplant patients, and newborn babies, life threatening CMV disease can occur. The HCMV major immediate-early enhancer functions as a master regulatory switch, whose activation is essential for the expression of the major IE transactivating proteins, IE1 p72 and IE2 p86. While critical to the viral lifecycle, regulation of MIE enhancer activation is very complex and not yet fully understood. I characterized
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33

Lee, Ming-Kang. "PRC1, PRC2 and BAP1 : Three tightly-linked chromatin modifiers involved in transcriptional regulation." Electronic Thesis or Diss., Université Paris sciences et lettres, 2021. http://www.theses.fr/2021UPSLS055.

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Chez les eucaryotes, la maintenance de l’identité cellulaire implique le contrôle précis de l’expression des gènes. Ceci résulte de l’action concertée des facteurs de transcription et des facteurs contrôlant la structure de la chromatine. Les complexes répresseurs Polycomb (PRC1 et PRC2) sont des modificateurs de la chromatine qui orchestrent la répression transcriptionnelle en catalysant respectivement l’ubiquitinylation de H2A (H2Aub) et la méthylation de H3K27. A l’inverse, BAP1 (BRCA1-Associated Protein 1) favorise la transcription en retirant H2Aub, agissant donc comme un antagoniste de P
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34

Heintzman, Nathaniel David. "Identification and characterization of transcriptional enhancers in the human genome." Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3273474.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed April 9, 2008). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references.
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Ochs, Sharon D. "Elucidating transcription factor regulation by TCDD within the hs1,2 enhancer." Wright State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=wright1333992865.

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36

Gomes, Faria Rosa. "Candidate enhancer and transcription dynamics in early Xenopus tropicalis development." Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10047631/.

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A previous study from the Gilchrist lab measured transcription in the Xenopus tropicalis embryo for the first 66 hours of development at a high temporal resolution. This data showed that early transcription in Xenopus tropicalis is a very dynamic process, indicating that the mechanisms regulating it should also present dynamic behaviours. The aim of this project was to understand the dynamics of enhancer usage and investigate whether this correlates with gene transcription, using p300 as an enhancer proxy and Xenopus tropicalis as a model. A 12.5-hour p300 ChIP-seq high-resolution time series,
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Harshman, Keith D. Parker Carl Stevens Parker Carl Stevens. "Isolation and characterization of factors that interact with eukaryotic transcriptional enhancers /." Diss., Pasadena, Calif. : California Institute of Technology, 1989. http://resolver.caltech.edu/CaltechETD:etd-05222007-152402.

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38

Mitchelmore, Joanna. "Investigation of transcription factor binding at distal regulatory elements." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/277805.

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Cellular development and function necessitate precise patterns of gene expression. Control of gene expression is in part orchestrated by a class of remote regulatory elements, termed enhancers, which are brought into contact with promoters via DNA looping. Enhancers typically contain clusters of transcription factor binding sites, and TF recruitment to them is thought to play a key role in transcriptional control. In this thesis I have addressed two issues regarding gene regulation by enhancers. First, with recent genome-wide enhancer mapping, it is becoming increasingly apparent that genes ar
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39

Sealfon, Rachel (Rachel Sima). "Predicting enhancer regions and transcription factor binding sites in D. melanogaster." Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/62434.

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Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2010.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references (p. 71-75).<br>Identifying regions in the genome that have regulatory function is important to the fundamental biological problem of understanding the mechanisms through which a regulatory sequence drives specific spatial and temporal patterns of gene expression in early development. The modENCODE project aims to comprehensively identify functional elements in the C. elegans and D. melanogaster genomes.
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Kuang, Yi. "Enhancer Binding Site Architecture Regulates Cell-specific Notch Signal Strength and Transcription." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1595850476033711.

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41

Williams, Trevor Julian. "The analysis of a transcriptionally active region surrounding a mouse enhancer sequence." Thesis, Imperial College London, 1986. http://hdl.handle.net/10044/1/38190.

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42

Berggård, Cecilia. "Transcription factor AP-2 in relation to personality and antidepressant drugs /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4638.

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43

Hughes, Amanda Dawn. "Mechanism of enhancer-dependent transcription in Escherichia coli by σⁿ-RNA polymerase." Thesis, University of York, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.399583.

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44

Lawton, Edward. "Self association and transcription activation determinants in a bacterial enhancer binding protein." Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/29205.

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Bacterial transcription initiation relies on the binding of a dissociable sigma factor to the catalytic RNA polymerase (RNAP) 'core' enzyme to enable promoter specific DNA recognition. While the initial σ70 RNAP-promoter DNA bound complex (termed the closed complex) can spontaneously isomerise to form open promoter complexes, RNAP containing the major variant, the σ54 factor requires activation by bacterial enhancer binding proteins (bEBPs) which reorganize the initial closed promoter complex to an open complex in an ATP consuming reaction. These bEBPs belong to the AAA+ (ATPases associated wi
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45

Brunelle, Mylène. "Étude de l'influence du variant d'histone H2A.Z sur l'organisation des nucléosomes aux enhancers liés par le récepteur alpha de l'oestrogène." Thèse, Université de Sherbrooke, 2016. http://hdl.handle.net/11143/8867.

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L'identité et la réactivité cellulaires sont établies, maintenues et modulées grâce à l'orchestration de programmes transcriptionnels spécifiques. Les éléments régulateurs, des régions particulières de la chromatine responsables de l'activation ou de la répression des gènes, sont au coeur de cette opération. Ces dernières années, de nombreuses études ont révélé le rôle central des « enhancers » dans ce processus. En effet, des centaines de milliers « enhancers » seraient éparpillés dans le génome humain, majoritairement dans sa portion non-codante, et contrairement au promoteur, leur activatio
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46

Sutter, Nathaniel Barrett. "Suppression of stable and variegating position effects by the 5'HS2 and inducible 3MRE enhancers /." Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/5038.

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Berg, Tove. "C/EBP transcription factors in lung cellular differentiation and development /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-586-0/.

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Andzelm, Milena Maria. "Functional and genomic analysis of MEF2 transcription factors in neural development." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070059.

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Development of the central nervous system requires the precise coordination of intrinsic genetic programs to instruct cell fate, synaptic connectivity and function. The MEF2 family of transcription factors (TFs) plays many essential roles in neural development; however, the mechanisms of gene regulation by MEF2 in neurons remain unclear. This dissertation focuses on the molecular mechanisms by which MEF2 binds to the genome, activates enhancers, and regulates gene expression within the developing nervous system. We find that one MEF2 family member in particular, MEF2D, is an essential regulato
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Laurencikiene, Jurga. "Regulation of germline transcription in the immunoglobulin heavy chain locus /." Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-989-7/.

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Harrison, Wesley John. "The role of CCAAT enhancer binding protein transcription factors in sebaceous gland cell differentiation." Thesis, Queen Mary, University of London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.439889.

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