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Dissertations / Theses on the topic 'Transcriptional interference'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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1

Greger, Ingo Harald. "Transcriptional interference between highly expressed eukaryotic genes." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298678.

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2

Watts, Beth Rosina. "Investigating mechanisms of transcriptional interference in Schizosaccharomyces pombe." Thesis, University of Oxford, 2015. https://ora.ox.ac.uk/objects/uuid:c919478f-21e9-4061-81aa-4ec1ae41d223.

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Eukaryotic cells transcribe a vast array of non-coding RNAs, most of which have not been assigned a functional role. The work presented here reveals a novel mechanism of transcriptional repression that is mediated by the non-coding RNA prt (pho1-repressing transcript). The prt transcript is shown to recruit a histone deacetylase, Clr3, to repress pho1. This gene encodes a secreted acid phosphatase essential for phosphate acquisition in fission yeast. In the presence of phosphate, prt is produced from an upstream promoter and leads to silencing of pho1. Thus far, this has been explained by prt

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3

Chiu, Ya-Lin. "HIV-1 Gene Expression: Transcriptional Regulation and RNA Interference Studies: a Dissertation." eScholarship@UMMS, 2003. https://escholarship.umassmed.edu/gsbs_diss/118.

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Gene expression of human immunodeficiency virus type-1 (HIV-1), which causes Acquired Immunodeficiency Syndrome (AIDS), is regulated at the transcriptional level, where negative factors can block elongation that is overcome by HIV Tat protein and P-TEFb. P-TEFb, a positive elongation transcription factor with two subunits, CDK9 and Cyclin T1 (CycT1), catalyzes Tat-dependent phosphorylation of Ser-5 in the Pol II C-terminal domain (CTD), allowing production of longer mRNAs. Ser-5 phosphorylation enables the CTD to recruit mammalian mRNA capping enzyme (Mce1) and stimulate its guanylyltransferas

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4

Thomson, Gabrielle Anne Biotechnology &amp Biomolecular Sciences Faculty of Science UNSW. "Retroelements as controlling elements in mammals." Awarded by:University of New South Wales. Biotechnology and Biomolecular Sciences, 2006. http://handle.unsw.edu.au/1959.4/26203.

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Retroelements are genomic parasites which make up ~42% of the human genome and 38% of the mouse genome. Most are degenerate, but a large number have relatively intact promoter elements, suggesting that they are capable of transcription. Transcriptionally active retroelements can perturb normal transcription units in their vicinity through a variety of mechanisms, leading to phenotypic effects and in some cases disease. This phenomenon of transcriptional interference has been observed in organisms as diverse as maize, Drosophila, and the mouse. We analysed the extent of retroelement transcr

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5

Puram, Rishi Venkata. "Defining and Targeting Transcriptional Pathways in Leukemia Stem Cells." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13070042.

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Acute myeloid leukemia (AML) is a clonal neoplastic disorder organized as a cellular hierarchy, with the self-renewing leukemia stem cell (LSC) at the apex. Recurrent mutations in transcription factors (TF) and epigenetic regulators suggest that AML is driven by aberrant transcriptional circuits, but these circuits have not been fully defined in an LSC model. To study transcriptional mechanisms relevant to leukemogenesis in vivo, we generated a murine serial transplantation model of MLL-AF9-driven, myelomonocytic leukemia with genetically- and phenotypically-defined LSCs. Using this model,

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6

Racanelli, Alexandra. "TRANSCRIPTIONAL, EPIGENETIC, AND SIGNAL EVENTS IN ANTIFOLATE THERAPEUTICS." VCU Scholars Compass, 2009. http://scholarscompass.vcu.edu/etd/1876.

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A targeted approach to the development of antifolate therapies has been sought for many years. Central to the success of such development is an understanding of the molecular mechanisms dictating the sensitivity of cells to antifolates and the fundamental differences of these processes between normal and neoplastic phenotypes. This dissertation addressed transcriptional mechanisms and cell-signaling events responsible for the efficacy of antifolate therapies. Transcriptional processes and cell signaling pathways are often aberrant in neoplastic tissues, providing a potential point of distincti

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7

Mulder, Jaap. "Towards treatment of cholestatic liver disease in children via interference with transcriptional regulation of hepatic transport systems." [S.l. : [Groningen : s.n.] ; University Library Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/.

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8

Chery, Alicia. "Rôle de la transcription pervasive antisens chez Saccharomyces cerevisiae dans la régulation de l'expression des gènes." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066191/document.

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L'expression des gènes est finement régulée dans la cellule et soumise à de multiples contrôles-qualité. Cette régulation intervient à différents niveaux, de façon à garantir une synthèse efficace des produits fonctionnels de l'expression génique, et pour assurer une adaptation à un changement environnemental. Notamment, les régulations transcriptionnelles sont cruciales pour contrôler la cinétique et le niveau d'expression des gènes. La transcription pervasive est une transcription généralisée non-codante et instable qui fut révélée chez la levure Saccharomyces cerevisiae. Bien que son potent

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9

Haley, Benjamin. "A Biochemical Dissection of the RNA Interference Pathway in Drosophila melanogaster: A Dissertation." eScholarship@UMMS, 2005. https://escholarship.umassmed.edu/gsbs_diss/9.

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In diverse eukaryotic organisms, double-stranded RNA (dsRNA) induces robust silencing of cellular RNA cognate to either strand of the input dsRNA; a phenomenon now known as RNA interference (RNAi). Within the RNAi pathway, small, 21 nucleotide (nt) duplexed RNA, dubbed small interfering RNAs (siRNAs), derived from the longer input dsRNA, guide the RNA induced silencing complex (RISC) to destroy its target RNA. Due to its ability to silence virtually any gene, whether endogenous or exogenous, in a variety of model organisms and systems, RNAi has become a valuable laboratory tool, and is even be

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10

Chery, Alicia. "Rôle de la transcription pervasive antisens chez Saccharomyces cerevisiae dans la régulation de l'expression des gènes." Electronic Thesis or Diss., Paris 6, 2017. http://www.theses.fr/2017PA066191.

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L'expression des gènes est finement régulée dans la cellule et soumise à de multiples contrôles-qualité. Cette régulation intervient à différents niveaux, de façon à garantir une synthèse efficace des produits fonctionnels de l'expression génique, et pour assurer une adaptation à un changement environnemental. Notamment, les régulations transcriptionnelles sont cruciales pour contrôler la cinétique et le niveau d'expression des gènes. La transcription pervasive est une transcription généralisée non-codante et instable qui fut révélée chez la levure Saccharomyces cerevisiae. Bien que son potent

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11

Forero, McGrath Monica. "Identification of Genes Associated with the Endocrine Heart under Normal and Pathophysiological Conditions Using Genomic and Transcriptional Analysis." Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20262.

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The endocrine heart synthesises and secretes two polypeptide hormones: the natriuretic peptides (NP) atrial natriuretic factor (ANF) and B-type natriuretic peptide (BNP). The biological actions of these hormones serve both acutely and chronically to reduce systemic blood pressure and hemodynamic load to the heart, thus contributing to the maintenance of cardiorenal homeostasis. Considerable effort has been focused on the elucidation of the mechanistic underlying ANF and BNP gene expression and secretion but much remains to be determined regarding specific molecular events involved in the cardi

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12

Gallastegui, Calvache Edurne. "Influencia de la cromatina en el lugar de integración sobre la actividad del promotor del virus de la immunodeficiencia humana y el establecimiento de la latencia viral." Doctoral thesis, Universitat Pompeu Fabra, 2010. http://hdl.handle.net/10803/22683.

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El establecimiento de un reservorio latente del virus del HIV en células T CD4+ es la mayor barrera contra la erradicación de esta enfermedad. Para lograr su erradicación, se necesitaría combinar la terapia antirretroviral HAART con drogas capaces de reactivar los virus durmientes. El objetivo principal de este estudio es entender cómo se establece la latencia tras la integración del virus en el genoma, con el propósito de identificar factores involucrados que pudieran ser dianas de una nueva terapia. Hemos generado una librería de clones que contienen un minigenoma latente del virus que expre

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13

Tsao, Theresa Tsun-Hui. "Towards the development of transgenic banana bunchy top virus (BBTV)-resistant banana plants : interference with replication." Thesis, Queensland University of Technology, 2008. https://eprints.qut.edu.au/17031/1/Theresa_Tsao_Thesis.pdf.

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Banana bunchy top virus (BBTV) causes one of the most devastating diseases of banana. Transgenic virus resistance is now considered one of the most promising strategies to control BBTV. Pathogen-derived resistance (PDR) strategies have been applied successfully to generate plants that are resistant to numerous different viruses, primarily against those viruses with RNA genomes. BBTV is a circular, single-stranded (css) DNA virus of the family Nanoviridae, which is closely related to the family Geminiviridae. Although there are some successful examples of PDR against geminiviruses, PDR against

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14

Tsao, Theresa Tsun-Hui. "Towards the development of transgenic banana bunchy top virus (BBTV)-resistant banana plants : interference with replication." Queensland University of Technology, 2008. http://eprints.qut.edu.au/17031/.

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Banana bunchy top virus (BBTV) causes one of the most devastating diseases of banana. Transgenic virus resistance is now considered one of the most promising strategies to control BBTV. Pathogen-derived resistance (PDR) strategies have been applied successfully to generate plants that are resistant to numerous different viruses, primarily against those viruses with RNA genomes. BBTV is a circular, single-stranded (css) DNA virus of the family Nanoviridae, which is closely related to the family Geminiviridae. Although there are some successful examples of PDR against geminiviruses, PDR against

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15

GRASSI, ANGELA. "Inference of gene regulation from expression data. Mathematical modeling and the design of a genomic study to investigate IFNa transcriptional response modulators." Doctoral thesis, Università degli studi di Padova, 2011. http://hdl.handle.net/11577/3421714.

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The main object of this thesis is the inference of gene regulation from quantitative gene expression data. This goal is of central importance for health care as complex genetic diseases such as cancer are caused by deregulation or aberrant regulation of genes. The thesis is structured into two main parts corresponding to a theoretical and a practical approach to the inference of gene regulation. In the first part of the thesis a Bayesian hierarchical model for the reconstruction of regulatory networks from gene expression microarray data is presented. In the second part of the thesis a novel e

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16

Miller, Tyler Eugene. "Identifying Novel In Vivo Epigenetic Dependencies in Glioblastoma." Case Western Reserve University School of Graduate Studies / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=case1464856610.

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17

Stelniec, Iwona. "Deregulation transkriptioneller Netzwerke in Abhängigkeit von onkogener KRAS-Signaltransduktion in einem Ovarialkarzinom-Modell." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16117.

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Tumormodelle, in denen die maligne Transformation durch definierte Onkogene experimentell ausgelöst und unterhalten wird, bieten vielfältige Möglichkeiten, die komplexen Mechanismen der Tumorentstehung und Therapieresistenz zu untersuchen und neue Ansätze für Diagnostik und Therapie auszuarbeiten. KRAS-Onkogen-„getriebene“ Transformationsmodelle spiegeln neben anderen tumorspezifischen Veränderungen insbesondere die charakteristischen Änderungen des Transkriptoms wider. In der vorliegenden Arbeit wird ein Modell für Ovarialtumore auf Grundlage von Rose Zellen („Rat ovarian surface epithelium“)

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18

Buchholz, Frank, Anja Nitzsche, Maciej Paszkowski-Rogacz, Filomena Matarese, Eva M. Janssen-Megens, Nina C. Hubner, Herbert Schulz, et al. "RAD21 Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-191596.

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For self-renewal, embryonic stem cells (ESCs) require the expression of specific transcription factors accompanied by a particular chromosome organization to maintain a balance between pluripotency and the capacity for rapid differentiation. However, how transcriptional regulation is linked to chromosome organization in ESCs is not well understood. Here we show that the cohesin component RAD21 exhibits a functional role in maintaining ESC identity through association with the pluripotency transcriptional network. ChIP-seq analyses of RAD21 reveal an ESC specific cohesin binding pattern that is

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19

Meyer, Marc-Étienne. "Les récepteurs des hormones stéroïdes entrent en compétition pour des facteurs intervenant dans leur activité transcriptionnelle." Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M199.

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20

Cheung, Man-sze, and 張敏思. "Investigating the role of FoxM1 in cell cycle progression by inducibleRNA interference." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B30396402.

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21

Buchholz, Frank, Anja Nitzsche, Maciej Paszkowski-Rogacz, Filomena Matarese, Eva M. Janssen-Megens, Nina C. Hubner, Herbert Schulz, et al. "RAD21 Cooperates with Pluripotency Transcription Factors in the Maintenance of Embryonic Stem Cell Identity." Public Library of Science, 2011. https://tud.qucosa.de/id/qucosa%3A29134.

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For self-renewal, embryonic stem cells (ESCs) require the expression of specific transcription factors accompanied by a particular chromosome organization to maintain a balance between pluripotency and the capacity for rapid differentiation. However, how transcriptional regulation is linked to chromosome organization in ESCs is not well understood. Here we show that the cohesin component RAD21 exhibits a functional role in maintaining ESC identity through association with the pluripotency transcriptional network. ChIP-seq analyses of RAD21 reveal an ESC specific cohesin binding pattern that is

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22

Serra, Ryan W. "Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation." eScholarship@UMMS, 2013. https://escholarship.umassmed.edu/gsbs_diss/676.

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The development of RNAi based technologies has given researchers the tools to interrogate processes as diverse as cancer biology, metabolism and organ development. Here I employ genome-wide shRNA screens to discover the genes involved in two different processes in carcinogenesis, oncogene-induced senescence [OIS] and epigenetic silencing of tumor suppressor genes [TSGs]. OIS is a poorly studied yet significant tumor suppressing mechanism in normal cells where they enter cell cycle arrest [senescence] or programmed cell death [apoptosis] in the presence of an activated oncogene. Here I employ a

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23

Serra, Ryan W. "Investigating Cancer Molecular Genetics using Genome-wide RNA Interference Screens: A Dissertation." eScholarship@UMMS, 2006. http://escholarship.umassmed.edu/gsbs_diss/676.

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The development of RNAi based technologies has given researchers the tools to interrogate processes as diverse as cancer biology, metabolism and organ development. Here I employ genome-wide shRNA screens to discover the genes involved in two different processes in carcinogenesis, oncogene-induced senescence [OIS] and epigenetic silencing of tumor suppressor genes [TSGs]. OIS is a poorly studied yet significant tumor suppressing mechanism in normal cells where they enter cell cycle arrest [senescence] or programmed cell death [apoptosis] in the presence of an activated oncogene. Here I employ a

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24

Chapman, Elliott. "Investigating the role of RNA interference in the fission yeast Schizosaccharomyces japonicus." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31201.

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RNA interference (RNAi) is a conserved pathway that plays key roles in heterochromatin formation, gene regulation and genome surveillance across a wide range of eukaryotes. One of the most utilised model organisms for studying the RNAi pathway is the fission yeast Schizosaccharomyces pombe. However, this species is somewhat atypical, in that it has not retained the ancestral role for RNAi in the silencing of mobile genetic elements. In contrast, the related fission yeast S. japonicus has a large and diverse retrotransposon complement that appears to give rise to abundant siRNAs. For this reaso

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25

Rangarajan, Aathmaja Anandhi [Verfasser], Karin [Gutachter] Schnetz, and Jürgen [Gutachter] Dohmen. "Interference of transcription on H-NS mediated repression in Escherichia coli / Aathmaja Anandhi Rangarajan ; Gutachter: Karin Schnetz, Jürgen Dohmen." Köln : Universitäts- und Stadtbibliothek Köln, 2018. http://d-nb.info/115492954X/34.

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26

Natalin, Pavel. "Post-transcriptional gene regulation in Drosophila an investigation into the roles of RNA silencing and the DEAD-box helicase Belle /." [S.l. : s.n.], 2009. http://nbn-resolving.de/urn:nbn:de:bsz:16-opus-89391.

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27

Thurisch, Boris. "Untersuchung der Funktion des Transkriptionsfaktors GATA-4 durch eine Mausmutante mit einem induzierbaren RNA-Interferenz System." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15703.

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Hintergrund: Der Transkriptionsfaktor GATA-4 ist für die normale Entwicklung des Endoderms essentiell. Mausmutanten mit einer homozygoten Deletion des gata-4 Gens versterben zwischen den embryonalen Tagen 8.5 - 10.5 aufgrund einer Störung der ventralen Morphogenese und der Ausbildung des Herzschlauches. Zielsetzung und experimentelle Strategie: Um die Bedeutung von GATA-4 auch nach der embryonalen Entwicklung untersuchen zu können, wurden doppelt-transgene Mäuse generiert. Diese Mausmutanten exprimieren einen Tetrazyklin-Repressor und eine gegen GATA-4 gerichtete short hairpin RNA (shGATA-4)

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28

Chu, Alphonse. "A Functional Genomics Approach for Characterizing the Role of Six Transcription Factors in Muscle Development." Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/22860.

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Proper development of skeletal muscle occurs through a highly complex process where activation and repression of genes are essential. Control of this process is regulated by timely and spatial expression of specific transcription factors (TFs). Six1 and Six4 are homeodomain TFs known to be essential for skeletal muscle development in mice. Using the C2C12 cell line, a model for skeletal muscle differentiation, I used a functional genomics approach, employing siRNA specific to both these TFs, to characterize their role in skeletal myogenesis. To identify the genes that are regulated by both the

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29

Yang, Chao-Shun. "Molecular Landscape of Induced Reprogramming: A Dissertation." eScholarship@UMMS, 2014. https://escholarship.umassmed.edu/gsbs_diss/698.

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Recent breakthroughs in creating induced pluripotent stem cells (iPS cells) provide alternative means to obtain embryonic stem (ES) cell-like cells without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or Nanog/Lin28) into somatic cells. However, the molecular basis of reprogramming is largely unknown. To address this question, we employed microRNAs, small molecules, and conducted genome-wide RNAi screen, to investigate the regulatory mechanisms of reprogramming. First we showed that depleting miR-21 and miR-29a enhances reprogramming in mouse embry

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Yang, Chao-Shun. "Molecular Landscape of Induced Reprogramming: A Dissertation." eScholarship@UMMS, 2002. http://escholarship.umassmed.edu/gsbs_diss/698.

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Recent breakthroughs in creating induced pluripotent stem cells (iPS cells) provide alternative means to obtain embryonic stem (ES) cell-like cells without destroying embryos by introducing four reprogramming factors (Oct3/4, Sox2, and Klf4/c-Myc or Nanog/Lin28) into somatic cells. However, the molecular basis of reprogramming is largely unknown. To address this question, we employed microRNAs, small molecules, and conducted genome-wide RNAi screen, to investigate the regulatory mechanisms of reprogramming. First we showed that depleting miR-21 and miR-29a enhances reprogramming in mouse embry

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31

Pereira, Ana Helena Macedo 1980. "Influencia do fator de transcrição MEF2C na hipertrofia miocardica induzida por sobrecarga pressorica em camundongos." [s.n.], 2008. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310214.

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Orientador: Kleber Gomes Franchini<br>Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas<br>Made available in DSpace on 2018-08-11T20:15:36Z (GMT). No. of bitstreams: 1 Pereira_AnaHelenaMacedo_M.pdf: 6567293 bytes, checksum: b9a8c070b3b65fe7a4fb095ccfc59d42 (MD5) Previous issue date: 2008<br>Resumo: Doenças do coração são freqüentemente associadas à hipertrofia miocárdica. Estímulos mecânicos induzem o crescimento hipertrófico e contribuem para a degeneração e morte dos miócitos cardíacos. Dentre os fatores de transcrição envolvidos no processo de hiper

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Oliveira, Maria Theresa de [UNIFESP]. "O uso de interferência por RNA para a análise da função do gene E2F1 na progressão do ciclo celular em células tumorais." Universidade Federal de São Paulo (UNIFESP), 2010. http://repositorio.unifesp.br/handle/11600/9874.

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Made available in DSpace on 2015-07-22T20:50:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2010-10-27. Added 1 bitstream(s) on 2015-08-11T03:25:30Z : No. of bitstreams: 1 Publico-00376a.pdf: 1954101 bytes, checksum: ab9812845158d2c4c296f255d1304dac (MD5). Added 1 bitstream(s) on 2015-08-11T03:25:30Z : No. of bitstreams: 2 Publico-00376a.pdf: 1954101 bytes, checksum: ab9812845158d2c4c296f255d1304dac (MD5) Publico-00376b.pdf: 1910033 bytes, checksum: 3104d18a155b521c486f36410aae2b4c (MD5). Added 1 bitstream(s) on 2015-08-11T03:25:30Z : No. of bitstreams: 3 Publico-00376a.pdf: 19541

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Gamsby, Joshua John. "Study of the roles of LRBA in cancer cell proliferation and SHIP-1 in NK cell function." [Tampa, Fla] : University of South Florida, 2005. http://purl.fcla.edu/usf/dc/et/SFE0001317.

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Neubauer, Svetlana. "Untersuchungen von inter- und intramolekularen Interaktionen des globalen Regulators AbrB und dessen Antirepressors AbbA." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2014. http://dx.doi.org/10.18452/16887.

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Aus den frühen Bindungsstudien des globalen Regulators AbrB mit der ausgedehnten phyC-Promotorregion von Bacillus amyloliquefaciens FZB45 konnte ein mehrstufiger kooperativer Bindungsprozess abgeleitet werden. Dabei verlangt die AbrB-vermittelte Repression von phyC nach Integrität zweier großer Bindungsstellen, ABS1 und ABS2, die 162 bp voneinander entfernt liegen. In der vorliegenden Arbeit wurden die ersten Echtzeitkinetiken zur DNA-AbrB-Interaktion mittels der Oberflächenplasmonresonanz (SPR) gemessen und analysiert. AbrB zeigte hohe Affinitäten zu den 40 bp langen Oligonukleotiden, die de

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35

Leobold, Matthieu. "Démonstration fonctionnelle de la nature virale des particules sans ADN de la guêpe parasitoïde venturia canescens." Thesis, Tours, 2018. http://www.theses.fr/2018TOUR4017.

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Chez la guêpe parasitoïde Venturia canescens, des particules virales dépourvues d'ADN appelées VLP (pour "Virus-like Particules") sont produites spécifiquement dans les ovaires et tapissent le chorion des oeufs qui sont injectés dans la chenille hôte. Les VLP ont une fonction immunosuppressive pour l'hôte parasité et permettent ainsi la survie des oeufs du parasitoïde. Ces VLP résultent de l’intégration d’un nudivirus dans le génome de l’ancêtre de la guêpe, nudivirus qui a été ensuite domestiqué pour former des liposomes viraux capables de véhiculer dans l’hôte des protéines de virulence d'or

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Harmse, Johan. "Engineering virus resistant transgenic cassava: the design of long hairpin RNA constructs against South African cassava mosaic virus." Thesis, 2008. http://hdl.handle.net/10539/4685.

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ABSTRACT Cassava is currently the second most important source of carbohydrates on the African continent. In the last two decades, cassava crops have been severely affected by outbreaks of cassava mosaic disease (CMD). South African cassava mosaic virus (SACMV) has been associated with CMD outbreaks in the Mpumalanga province. Advances in post-transcriptional gene silencing (PTGS) technology have provided promising new strategies for the engineering of virus resistance in plants. Inverted repeat (IR) constructs are currently the most potent inducers of PTGS, however, these constructs a

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Barichievy, Samantha. "Post-transcriptional inhibition of human immunodeficiency virus type 1 (HIV-1) using combinatorial RNA interference (RNAi) expression vectors." Thesis, 2010. http://hdl.handle.net/10539/8282.

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Recent estimates indicate that globally there are over 33 million people infected with Human Immunodeficiency Virus type 1 (HIV-1). The epidemic is particularly severe in sub-Saharan Africa which accounts for 67% of all infected individuals and 72% of AIDS deaths in 2007. While current therapies, particularly in combination as a cocktail of highly active antiretroviral therapy (HAART), have had an important positive impact on the morbidity and mortality of HIV-related illness, there remain significant limitations. These include toxicities, resistance and the inability to eradicate a latent inf

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38

Callen, Benjamin Peter. "A mechanism for transcriptional interference between convergent promoters in the developmental switch of bacteriophage 186 / Benjamin Peter Callen." Thesis, 2003. http://hdl.handle.net/2440/21919.

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Callen, Benjamin Peter. "A mechanism for transcriptional interference between convergent promoters in the developmental switch of bacteriophage 186 / Benjamin Peter Callen." 2003. http://hdl.handle.net/2440/21919.

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"March 2003"<br>Bibliography: leaves 133-143.<br>x, 143 leaves : ill. (some col.) ; 30 cm.<br>Title page, contents and abstract only. The complete thesis in print form is available from the University Library.<br>Thesis (Ph.D.)--University of Adelaide, School of Molecular and Biomedical Sciences, 2003

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Pena, Frederico Mendes e. "CRISPR-mediated pre-transcriptional silencing of ATXN3, the gene involved in Machado-Joseph disease." Master's thesis, 2018. http://hdl.handle.net/10316/86118.

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Dissertação de Mestrado em Bioquímica apresentada à Faculdade de Ciências e Tecnologia<br>Ataxia espinocerebelosa do tipo 3 (SCA3) ou doença de Machado-Joseph (MJD) é uma doença neurodegenerativa e descrita como como a forma mundialmente mais comum de ataxia com hereditariedade autossómica dominante. Pertencendo ao grupo das doenças de poliglutaminas, SCA3 é causada por uma expansão anormal de uma repetição de trinucleótidos CAG (que codificam glutamina) no exão 10 do gene ATXN3, afectando maioritariamente áreas anteriores do cérebro, tais como o cerebelo, o tronco cerebral e a parte superior

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Růžičková, Adéla. "Vliv způsobu indukce RNA interference na umlčování reportérového genu pro GFP u Arabidopsis thaliana." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-353799.

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RNA interference (RNAi) is one of the key mechanisms that are involved in many biological processes such as control of plant gene expression, influence on chromatin arrangement or providing protection against invasive DNA or RNA transposons, viruses and transgenes. In plants, RNAi is triggered by double stranded RNA (dsRNA) that is cleaved by DICER LIKE (DCL) proteins to small RNAs (sRNAs). The size of these sRNAs is in range of 21 - 24 nucleotides (nt). Small RNA acts in the place of origin and they are also a mobile signal which in plants can move to a short distance through plasmodesmata an

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Chetal, Kashish. "OperomeDB: database of condition specific transcription in prokaryotic genomes and genomic insights of convergent transcription in bacterial genomes." Thesis, 2014. http://hdl.handle.net/1805/6228.

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Indiana University-Purdue University Indianapolis (IUPUI)<br>My thesis comprises of two individual projects: 1) we have developed a database for operon prediction using high-throughput sequencing datasets for bacterial genomes. 2) Genomics and mechanistic insights of convergent transcription in bacterial genomes. In the first project we developed a database for the prediction of operons for bacterial genomes using RNA-seq datasets, we predicted operons for bacterial genomes. RNA-seq datasets with different condition for each bacterial genome were taken into account and predicted operons usin

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MERGLOVÁ, Linda. "The regulation of transcription by the nuclear receptor NHR-25 in \kur{Caenorhabditis elegans}." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-51281.

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In this study, I utilized the defined (target) sequence for transcription factor NHR-25 and GFP as a marker to visualize where nhr-25 is active during the development in vivo. After obtaining worm strains carrying these constructs, the expression pattern was analyzed and the specificity of the expression was tested by means of RNAi.

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Lyons, MR, and AE West. "Mechanisms of specificity in neuronal activity-regulated gene transcription." Thesis, 2011. http://hdl.handle.net/10161/5425.

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The brain is a highly adaptable organ that is capable of converting sensory information into changes in neuronal function. This plasticity allows behavior to be accommodated to the environment, providing an important evolutionary advantage. Neurons convert environmental stimuli into long-lasting changes in their physiology in part through the synaptic activity-regulated transcription of new gene products. Since the neurotransmitter-dependent regulation of Fos transcription was first discovered nearly 25 years ago, a wealth of studies have enriched our understanding of the molecular pathways th

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Drewelus, Isabella. "Die Interferenz des Tumorsuppressor-Homologen p63 mit dem kanonischen Wnt-Signalweg." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-AD95-B.

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Čermák, Vojtěch. "Studium mechanismu posttranskripčního a transkripčního umlčování transgenů v buněčné linii tabáku BY-2." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-306690.

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The RNA interference is a mechanism, which allows cells to regulate their genes functions, to establish and maintain heterochromatin and to defend them against invasive nucleic acids. In plants, RNA interference is initiated by double-stranded RNA, which is processed by Dicer into small RNAs, usually 20-24nt long. These small RNAs form a complex with Argonaut protein that participates in different processes based on sequence complementarity. This complex can guide mRNA cleavage, translation blocking and chromatin modifications, resulting either into posttranscriptional silencing (by preventing

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Nagampalli, Vijay Krishna. "Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe." Thesis, 2014. http://etd.iisc.ac.in/handle/2005/3515.

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Gene deletions are a powerful method to uncover the cellular functions of a given gene in living systems. A limitation to this methodology is that it is not applicable to essential genes. Even for non-essential genes, gene knockouts cause complete absence of gene product thereby limiting genetic analysis of the biological pathway. Alternatives to gene deletions are mutants that are conditional, for e.g, temperature sensitive (ts) mutants are robust tools to understand temporal and spatial functions of genes. By definition, products of such mutants have near normal activity at a lower temperatu

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Nagampalli, Vijay Krishna. "Design and Application of Temperature Sensitive Mutants in Essential Factors of RNA Splicing and RNA Interference Pathway in Schizosaccharomyces Pombe." Thesis, 2014. http://etd.iisc.ernet.in/2005/3515.

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Gene deletions are a powerful method to uncover the cellular functions of a given gene in living systems. A limitation to this methodology is that it is not applicable to essential genes. Even for non-essential genes, gene knockouts cause complete absence of gene product thereby limiting genetic analysis of the biological pathway. Alternatives to gene deletions are mutants that are conditional, for e.g, temperature sensitive (ts) mutants are robust tools to understand temporal and spatial functions of genes. By definition, products of such mutants have near normal activity at a lower temperatu

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Knight, J. R. P., Simon J. Allison, and J. Milner. "Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity." 2013. http://hdl.handle.net/10454/9551.

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Yes<br>The NAD(+)-dependent deacetylase SIRT1 is involved in diverse cellular processes, and has also been linked with multiple disease states. Among these, SIRT1 expression negatively correlates with cancer survival in both laboratory and clinical studies. Active regulator of SIRT1 (AROS) was the first reported post-transcriptional regulator of SIRT1 activity, enhancing SIRT1-mediated deacetylation and downregulation of the SIRT1 target p53. However, little is known regarding the role of AROS in regulation of SIRT1 during disease. Here, we report the cellular and molecular effects of RNAi-med

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