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Journal articles on the topic 'Transcriptional Regulation'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Cornut, Maxence, Emilie Bourdonnay, and Thomas Henry. "Transcriptional Regulation of Inflammasomes." International Journal of Molecular Sciences 21, no. 21 (2020): 8087. http://dx.doi.org/10.3390/ijms21218087.

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Inflammasomes are multimolecular complexes with potent inflammatory activity. As such, their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this review, we present the transcriptional regulation of inflammasome genes from sensors (e.g., NLRP3) to substrates (e.g., IL-1β). Lineage-determining transcription factors shape inflammasome responses in different cell types with profound consequences on the responsiveness to inflammasome-activating stimuli. Pro-inflammatory signals (sterile or microbial) have a key transcriptional impact on inflammasome genes,

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Lee, Pauline, Truksa Jaroslav, Hongfan Peng, and Ernest Beutler. "Transcriptional Regulation of Hepcidin by Iron." Blood 110, no. 11 (2007): 2664. http://dx.doi.org/10.1182/blood.v110.11.2664.2664.

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Abstract Transcriptional regulation by iron in mammalian systems is poorly understood. Hepcidin, a 25 amino acid peptide that plays a central role in iron homeostasis, is transcriptionally regulated by iron. A region of the murine hepcidin promoter 1.6 to 1.8 kb upstream from the start of translation was recently identified to be important in transcriptional regulation by iron (Truksa J, et al. The distal location of the iron responsive region of the hepcidin promoter. Blood DOI 10.1182/blood-2007-05-091108, 2007). In order to identify transcription factors that might be important in regulatio

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Wilson, Nicola K., Fernando J. Calero-Nieto, Rita Ferreira, and Berthold Göttgens. "Transcriptional regulation of haematopoietic transcription factors." Stem Cell Research & Therapy 2, no. 1 (2011): 6. http://dx.doi.org/10.1186/scrt47.

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Dutta, Chaitali, Prasanta K. Patel, Adam Rosebrock, Anna Oliva, Janet Leatherwood, and Nicholas Rhind. "The DNA Replication Checkpoint Directly Regulates MBF-Dependent G1/S Transcription." Molecular and Cellular Biology 28, no. 19 (2008): 5977–85. http://dx.doi.org/10.1128/mcb.00596-08.

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ABSTRACT The DNA replication checkpoint transcriptionally upregulates genes that allow cells to adapt to and survive replication stress. Our results show that, in the fission yeast Schizosaccharomyces pombe, the replication checkpoint regulates the entire G1/S transcriptional program by directly regulating MBF, the G1/S transcription factor. Instead of initiating a checkpoint-specific transcriptional program, the replication checkpoint targets MBF to maintain the normal G1/S transcriptional program during replication stress. We propose a mechanism for this regulation, based on in vitro phospho

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Shimizu, Kiminori, Julie K. Hicks, Tzu-Pi Huang, and Nancy P. Keller. "Pka, Ras and RGS Protein Interactions Regulate Activity of AflR, a Zn(II)2Cys6 Transcription Factor in Aspergillus nidulans." Genetics 165, no. 3 (2003): 1095–104. http://dx.doi.org/10.1093/genetics/165.3.1095.

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Abstract Sterigmatocystin (ST) is a carcinogenic polyketide produced by several filamentous fungi including Aspergillus nidulans. Expression of ST biosynthetic genes (stc genes) requires activity of a Zn(II)2Cys6 transcription factor, AflR. aflR is transcriptionally and post-transcriptionally regulated by a G-protein/cAMP/protein kinase A (PkaA) signaling pathway involving FlbA, an RGS (regulator of G-protein signaling) protein. Prior genetic data showed that FlbA transcriptional regulation of aflR was PkaA dependent. Here we show that mutation of three PkaA phosphorylation sites in AflR allow

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6

Hahn, Steven. "Transcriptional regulation." EMBO reports 9, no. 7 (2008): 612–16. http://dx.doi.org/10.1038/embor.2008.99.

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7

Helntz, Nathaniel. "Transcriptional regulation." Trends in Biochemical Sciences 16 (January 1991): 393. http://dx.doi.org/10.1016/0968-0004(91)90161-n.

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8

Matthews, J. L., M. G. Zwick, and M. R. Paule. "Coordinate regulation of ribosomal component synthesis in Acanthamoeba castellanii: 5S RNA transcription is down regulated during encystment by alteration of TFIIIA activity." Molecular and Cellular Biology 15, no. 6 (1995): 3327–35. http://dx.doi.org/10.1128/mcb.15.6.3327.

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Transcription of large rRNA precursor and 5S RNA were examined during encystment of Acanthamoeba castellanii. Both transcription units are down regulated almost coordinately during this process, though 5S RNA transcription is not as completely shut down as rRNA transcription. The protein components necessary for transcription of 5S RNA and tRNA were determined, and fractions containing transcription factors comparable to TFIIIA, TFIIIB, and TFIIIC, as well as RNA polymerase III and a 3'-end processing activity, were identified. Regulation of 5S RNA transcription could be recapitulated in vitro

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9

Desvergne, Béatrice, Liliane Michalik, and Walter Wahli. "Transcriptional Regulation of Metabolism." Physiological Reviews 86, no. 2 (2006): 465–514. http://dx.doi.org/10.1152/physrev.00025.2005.

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Our understanding of metabolism is undergoing a dramatic shift. Indeed, the efforts made towards elucidating the mechanisms controlling the major regulatory pathways are now being rewarded. At the molecular level, the crucial role of transcription factors is particularly well-illustrated by the link between alterations of their functions and the occurrence of major metabolic diseases. In addition, the possibility of manipulating the ligand-dependent activity of some of these transcription factors makes them attractive as therapeutic targets. The aim of this review is to summarize recent knowle

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Geng, Yanbiao, Peter Laslo, Kevin Barton, and Chyung-Ru Wang. "Transcriptional Regulation ofCD1D1by Ets Family Transcription Factors." Journal of Immunology 175, no. 2 (2005): 1022–29. http://dx.doi.org/10.4049/jimmunol.175.2.1022.

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11

Hermsen, Rutger, Sander Tans, and Pieter Rein ten Wolde. "Transcriptional Regulation by Competing Transcription Factor Modules." PLoS Computational Biology 2, no. 12 (2006): e164. http://dx.doi.org/10.1371/journal.pcbi.0020164.

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12

Hermsen, Rutger, Sander J. Tans, and Pieter Rein ten Wolde. "Transcriptional Regulation by Competing Transcription Factor Modules." PLoS Computational Biology preprint, no. 2006 (2005): e164. http://dx.doi.org/10.1371/journal.pcbi.0020164.eor.

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13

Bettegowda, Anilkumar, and Miles F. Wilkinson. "Transcription and post-transcriptional regulation of spermatogenesis." Philosophical Transactions of the Royal Society B: Biological Sciences 365, no. 1546 (2010): 1637–51. http://dx.doi.org/10.1098/rstb.2009.0196.

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Spermatogenesis in mammals is achieved by multiple players that pursue a common goal of generating mature spermatozoa. The developmental processes acting on male germ cells that culminate in the production of the functional spermatozoa are regulated at both the transcription and post-transcriptional levels. This review addresses recent progress towards understanding such regulatory mechanisms and identifies future challenges to be addressed in this field. We focus on transcription factors, chromatin-associated factors and RNA-binding proteins necessary for spermatogenesis and/or sperm maturati

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14

Jackson, Kelly A., Ruth A. Valentine, Lisa J. Coneyworth, John C. Mathers, and Dianne Ford. "Mechanisms of mammalian zinc-regulated gene expression." Biochemical Society Transactions 36, no. 6 (2008): 1262–66. http://dx.doi.org/10.1042/bst0361262.

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Mechanisms through which gene expression is regulated by zinc are central to cellular zinc homoeostasis. In this context, evidence for the involvement of zinc dyshomoeostasis in the aetiology of diseases, including Type 2 diabetes, Alzheimer's disease and cancer, highlights the importance of zinc-regulated gene expression. Mechanisms elucidated in bacteria and yeast provide examples of different possible modes of zinc-sensitive gene regulation, involving the zinc-regulated binding of transcriptional activators and repressors to gene promoter regions. A mammalian transcriptional regulatory mech

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Sui, Zhiyuan, Yongjie Zhang, Zhishuai Zhang, et al. "Analysis of Lin28B Promoter Activity and Screening of Related Transcription Factors in Dolang Sheep." Genes 14, no. 5 (2023): 1049. http://dx.doi.org/10.3390/genes14051049.

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The Lin28B gene is involved in the initiation of puberty, but its regulatory mechanisms remain unclear. Therefore, in this study, we aimed to study the regulatory mechanism of the Lin28B promoter by cloning the Lin28B proximal promoter for bioinformatic analysis. Next, a series of deletion vectors were constructed based on the bioinformatic analysis results for dual-fluorescein activity detection. The transcriptional regulation mechanism of the Lin28B promoter region was analyzed by detecting mutations in transcription factor-binding sites and overexpression of transcription factors. The dual-

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de Sá, Paula Mota, Allison J. Richard, Hardy Hang, and Jacqueline M. Stephens. "Transcriptional Regulation of Adipogenesis." Comprehensive Physiology 7, no. 2 (2017): 635–74. https://doi.org/10.1002/j.2040-4603.2017.tb00753.x.

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ABSTRACTAdipocytes are the defining cell type of adipose tissue. Once considered a passive participant in energy storage, adipose tissue is now recognized as a dynamic organ that contributes to several important physiological processes, such as lipid metabolism, systemic energy homeostasis, and whole‐body insulin sensitivity. Therefore, understanding the mechanisms involved in its development and function is of great importance. Adipocyte differentiation is a highly orchestrated process which can vary between different fat depots as well as between the sexes. While hormones, miRNAs, cytoskelet

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Guo, Song, Yunfei Guo, Yuanyuan Chen, Shuaishuai Cui, Chunmei Zhang, and Dahu Chen. "The role of CEMIP in cancers and its transcriptional and post-transcriptional regulation." PeerJ 12 (February 19, 2024): e16930. http://dx.doi.org/10.7717/peerj.16930.

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CEMIP is a protein known for inducing cell migration and binding to hyaluronic acid. Functioning as a hyaluronidase, CEMIP primarily facilitates the breakdown of the extracellular matrix component, hyaluronic acid, thereby regulating various signaling pathways. Recent evidence has highlighted the significant role of CEMIP in different cancers, associating it with diverse pathological states. While identified as a biomarker for several diseases, CEMIP’s mechanism in cancer seems distinct. Accumulating data suggests that CEMIP expression is triggered by chemical modifications to itself and other

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18

Weiss, Mitchell J. "Transcriptional Regulation of Erythropoiesis." Blood 114, no. 22 (2009): SCI—7—SCI—7. http://dx.doi.org/10.1182/blood.v114.22.sci-7.sci-7.

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Abstract Abstract SCI-7 Efforts to define the mechanisms of globin gene expression and transcriptional control of erythrocyte formation have provided key insights into our understanding of developmental hematopoiesis. Our group has focused on GATA-1, a zinc finger protein that was initially identified through its ability to bind a conserved cis element that regulates globin gene expression. GATA-1 is essential for erythroid development and mutations in the GATA1 gene are associated with human cytopenias and leukemia. Several general principles have emerged through studies to define the mechani

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Powell, Emily, Peter Kuhn та Wei Xu. "Nuclear Receptor Cofactors in PPARγ-Mediated Adipogenesis and Adipocyte Energy Metabolism". PPAR Research 2007 (2007): 1–11. http://dx.doi.org/10.1155/2007/53843.

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Transcriptional cofactors are integral to the proper function and regulation of nuclear receptors. Members of the peroxisome proliferator-activated receptor (PPAR) family of nuclear receptors are involved in the regulation of lipid and carbohydrate metabolism. They modulate gene transcription in response to a wide variety of ligands, a process that is mediated by transcriptional coactivators and corepressors. The mechanisms by which these cofactors mediate transcriptional regulation of nuclear receptor function are still being elucidated. The rapidly increasing array of cofactors has brought i

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20

Gerbal-Chaloin, Sabine, Martine Daujat, Jean-Marc Pascussi, Lydiane Pichard-Garcia, Marie-Jose Vilarem, and Patrick Maurel. "Transcriptional Regulation ofCYP2C9Gene." Journal of Biological Chemistry 277, no. 1 (2001): 209–17. http://dx.doi.org/10.1074/jbc.m107228200.

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21

Guo, Ing-Cherng, Meng-Chun Hu, and Bon-chu Chung. "Transcriptional regulation ofCYP11A1." Journal of Biomedical Science 10, no. 6 (2003): 593–98. http://dx.doi.org/10.1007/bf02256309.

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22

Tower, J., and B. Sollner-Webb. "Polymerase III transcription factor B activity is reduced in extracts of growth-restricted cells." Molecular and Cellular Biology 8, no. 2 (1988): 1001–5. http://dx.doi.org/10.1128/mcb.8.2.1001-1005.1988.

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Extracts of cells that are down-regulated for transcription by RNA polymerase I and RNA polymerase III exhibit a reduced in vitro transcriptional capacity. We have recently demonstrated that the down-regulation of polymerase I transcription in extracts of cycloheximide-treated and stationary-phase cells results from a lack of an activated subform of RNA polymerase I which is essential for rDNA transcription. To examine whether polymerase III transcriptional down-regulation occurs by a similar mechanism, the polymerase III transcription factors were isolated and added singly and in pairs to con

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23

Tower, J., and B. Sollner-Webb. "Polymerase III transcription factor B activity is reduced in extracts of growth-restricted cells." Molecular and Cellular Biology 8, no. 2 (1988): 1001–5. http://dx.doi.org/10.1128/mcb.8.2.1001.

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Extracts of cells that are down-regulated for transcription by RNA polymerase I and RNA polymerase III exhibit a reduced in vitro transcriptional capacity. We have recently demonstrated that the down-regulation of polymerase I transcription in extracts of cycloheximide-treated and stationary-phase cells results from a lack of an activated subform of RNA polymerase I which is essential for rDNA transcription. To examine whether polymerase III transcriptional down-regulation occurs by a similar mechanism, the polymerase III transcription factors were isolated and added singly and in pairs to con

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24

Disner, Geonildo R., Maria A. P. Falcão, Carla Lima, and Monica Lopes-Ferreira. "In Silico Target Prediction of Overexpressed microRNAs from LPS-Challenged Zebrafish (Danio rerio) Treated with the Novel Anti-Inflammatory Peptide TnP." International Journal of Molecular Sciences 22, no. 13 (2021): 7117. http://dx.doi.org/10.3390/ijms22137117.

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miRNAs regulate gene expression post-transcriptionally in various processes, e.g., immunity, development, and diseases. Since their experimental analysis is complex, in silico target prediction is important for directing investigations. TnP is a candidate peptide for anti-inflammatory therapy, first discovered in the venom of Thalassophryne nattereri, which led to miRNAs overexpression in LPS-inflamed zebrafish post-treatment. This work aimed to predict miR-21, miR-122, miR-731, and miR-26 targets using overlapped results of DIANA microT-CDS and TargetScanFish software. This study described 51

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Witzel, Ini-Isabée, Li Fang Koh, and Neil D. Perkins. "Regulation of cyclin D1 gene expression." Biochemical Society Transactions 38, no. 1 (2010): 217–22. http://dx.doi.org/10.1042/bst0380217.

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Cyclin D1 is a key regulator of cell proliferation and its expression is subject to both transcriptional and post-transcriptional regulation. In different cellular contexts, different pathways assume a dominant role in regulating its expression, whereas their disregulation can contribute to overexpression of cyclin D1 in tumorigenesis. Here, we discuss the ability of the NF-κB (nuclear factor κB)/IKK [IκB (inhibitor of NF-κB) kinase] pathways to regulate cyclin D1 gene transcription and also consider the newly discovered role of the SNARP (SNIP1/SkIP-associated RNA processing) complex as a co-

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Payne, Joshua L., Fahad Khalid, and Andreas Wagner. "RNA-mediated gene regulation is less evolvable than transcriptional regulation." Proceedings of the National Academy of Sciences 115, no. 15 (2018): E3481—E3490. http://dx.doi.org/10.1073/pnas.1719138115.

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Much of gene regulation is carried out by proteins that bind DNA or RNA molecules at specific sequences. One class of such proteins is transcription factors, which bind short DNA sequences to regulate transcription. Another class is RNA binding proteins, which bind short RNA sequences to regulate RNA maturation, transport, and stability. Here, we study the robustness and evolvability of these regulatory mechanisms. To this end, we use experimental binding data from 172 human and fruit fly transcription factors and RNA binding proteins as well as human polymorphism data to study the evolution o

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Sadka, Avi, Qiaoping Qin, Jianrong Feng, et al. "Ethylene Response of Plum ACC Synthase 1 (ACS1) Promoter is Mediated through the Binding Site of Abscisic Acid Insensitive 5 (ABI5)." Plants 8, no. 5 (2019): 117. http://dx.doi.org/10.3390/plants8050117.

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The enzyme 1-amino-cyclopropane-1-carboxylic acid synthase (ACS) participates in the ethylene biosynthesis pathways and it is tightly regulated transcriptionally and post-translationally. Notwithstanding its major role in climacteric fruit ripening, the transcriptional regulation of ACS during ripening is not fully understood. We studied fruit ripening in two Japanese plum cultivars, the climacteric Santa Rosa (SR) and its non-climacteric bud sport mutant, Sweet Miriam (SM). As the two cultivars show considerable difference in ACS expression, they provide a good system for the study of the tra

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Zhang, Wei, Jun Huang, and David E. Cook. "Histone modification dynamics at H3K27 are associated with altered transcription of in planta induced genes in Magnaporthe oryzae." PLOS Genetics 17, no. 2 (2021): e1009376. http://dx.doi.org/10.1371/journal.pgen.1009376.

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Transcriptional dynamic in response to environmental and developmental cues are fundamental to biology, yet many mechanistic aspects are poorly understood. One such example is fungal plant pathogens, which use secreted proteins and small molecules, termed effectors, to suppress host immunity and promote colonization. Effectors are highly expressedin plantabut remain transcriptionally repressedex planta, but our mechanistic understanding of these transcriptional dynamics remains limited. We tested the hypothesis that repressive histone modification at H3-Lys27 underlies transcriptional silencin

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Afzal, Zainab, and Robb Krumlauf. "Transcriptional Regulation and Implications for Controlling Hox Gene Expression." Journal of Developmental Biology 10, no. 1 (2022): 4. http://dx.doi.org/10.3390/jdb10010004.

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Hox genes play key roles in axial patterning and regulating the regional identity of cells and tissues in a wide variety of animals from invertebrates to vertebrates. Nested domains of Hox expression generate a combinatorial code that provides a molecular framework for specifying the properties of tissues along the A–P axis. Hence, it is important to understand the regulatory mechanisms that coordinately control the precise patterns of the transcription of clustered Hox genes required for their roles in development. New insights are emerging about the dynamics and molecular mechanisms governin

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Ouellette, A. J., R. Moonka, A. D. Zelenetz, and R. A. Malt. "Regulation of ribosome synthesis during compensatory renal hypertrophy in mice." American Journal of Physiology-Cell Physiology 253, no. 4 (1987): C506—C513. http://dx.doi.org/10.1152/ajpcell.1987.253.4.c506.

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Ribosomal synthesis was studied at the transcriptional and translational levels to investigate the mechanisms of ribosome accretion during compensatory renal hypertrophy. As measured by in vitro transcriptional runoff comparisons 6-48 h after surgery, nuclei from the kidney remaining after contralateral nephrectomy show an increase of up to 150% in the rate of synthesis of ribosomal precursor RNA. The rate of rDNA transcription is 40-50% greater than control values as early as 6 h after nephrectomy; by 48 h, the rate returns to normal. In contrast to the stimulated transcription of rDNA and ac

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O’Callaghan, Chris, Da Lin, and Thomas K. Hiron. "Intragenic transcriptional interference regulates the human immune ligand MICA." Journal of Immunology 200, no. 1_Supplement (2018): 109.23. http://dx.doi.org/10.4049/jimmunol.200.supp.109.23.

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Abstract Regulation of MICA expression is incompletely understood, but human MICA can be upregulated in cancer cells, virus-infected cells and rapidly proliferating cells. Binding of MICA to the activating NKG2D receptor on cytotoxic immune cells promotes elimination of the cell expressing MICA. We noted that MICA has tandem promoters that drive overlapping forward transcription. We show that the MICA gene contains a conserved upstream promoter that expresses a non coding transcript. Transcription from the upstream promoter represses transcription from the standard downstream MICA promoter in

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32

Nakayama, Koh, and Naoyuki Kataoka. "Regulation of Gene Expression under Hypoxic Conditions." International Journal of Molecular Sciences 20, no. 13 (2019): 3278. http://dx.doi.org/10.3390/ijms20133278.

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Eukaryotes are often subjected to different kinds of stress. In order to adjust to such circumstances, eukaryotes activate stress–response pathways and regulate gene expression. Eukaryotic gene expression consists of many different steps, including transcription, RNA processing, RNA transport, and translation. In this review article, we focus on both transcriptional and post-transcriptional regulations of gene expression under hypoxic conditions. In the first part of the review, transcriptional regulations mediated by various transcription factors including Hypoxia-Inducible Factors (HIFs) are

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Lv, Xiaoyang, Wei Sun, Shuangxia Zou, Ling Chen, Joram M. Mwacharo, and Jinyu Wang. "Characteristics of the BMP7 Promoter in Hu Sheep." Animals 9, no. 11 (2019): 874. http://dx.doi.org/10.3390/ani9110874.

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The BMP7 gene is involved in the growth and development of hair follicles but its regulation mechanism is unclear. We studied the regulation mechanism of the BMP7 promoter by cloning the proximal promoter of BMP7 for bioinformatics analysis. A series of missing vectors was then constructed for dual-fluorescein activity detection based on the bioinformatics analysis results. We tested transcription-factor binding-site mutations and transcription factor over-expression to analyze the transcriptional regulation principle of the BMP7 promoter region. The upstream transcriptional regulatory region

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Keller, Samuel H., Siddhartha G. Jena, Yuji Yamazaki, and Bomyi Lim. "Regulation of spatiotemporal limits of developmental gene expression via enhancer grammar." Proceedings of the National Academy of Sciences 117, no. 26 (2020): 15096–103. http://dx.doi.org/10.1073/pnas.1917040117.

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The regulatory specificity of a gene is determined by the structure of its enhancers, which contain multiple transcription factor binding sites. A unique combination of transcription factor binding sites in an enhancer determines the boundary of target gene expression, and their disruption often leads to developmental defects. Despite extensive characterization of binding motifs in an enhancer, it is still unclear how each binding site contributes to overall transcriptional activity. Using live imaging, quantitative analysis, and mathematical modeling, we measured the contribution of individua

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Yoshida, Toshimi, Esther Landhuis, Marei Dose, et al. "Transcriptional regulation of the Ikzf1 locus." Blood 122, no. 18 (2013): 3149–59. http://dx.doi.org/10.1182/blood-2013-01-474916.

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Key Points Multiple enhancers identified at the Ikzf1 locus with shared and distinct epigenetic and transcriptional properties. Transcription factor networks that distinguish between LMPP-specific and T cell–specific Ikzf1 enhancers.

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Ma, Qiuqin, Shihui Long, Zhending Gan, Gianluca Tettamanti, Kang Li, and Ling Tian. "Transcriptional and Post-Transcriptional Regulation of Autophagy." Cells 11, no. 3 (2022): 441. http://dx.doi.org/10.3390/cells11030441.

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Autophagy is a widely conserved process in eukaryotes that is involved in a series of physiological and pathological events, including development, immunity, neurodegenerative disease, and tumorigenesis. It is regulated by nutrient deprivation, energy stress, and other unfavorable conditions through multiple pathways. In general, autophagy is synergistically governed at the RNA and protein levels. The upstream transcription factors trigger or inhibit the expression of autophagy- or lysosome-related genes to facilitate or reduce autophagy. Moreover, a significant number of non-coding RNAs (micr

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Tirosh, Itay. "Transcriptional priming of cytoplasmic post-transcriptional regulation." Transcription 2, no. 6 (2011): 258–62. http://dx.doi.org/10.4161/trns.2.6.18608.

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Desgranges, Zana P., Jinwoo Ahn, Maria B. Lazebnik, et al. "Inhibition of TFII-I-Dependent Cell Cycle Regulation by p53." Molecular and Cellular Biology 25, no. 24 (2005): 10940–52. http://dx.doi.org/10.1128/mcb.25.24.10940-10952.2005.

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ABSTRACT The multifunctional transcription factor TFII-I is tyrosine phosphorylated in response to extracellular growth signals and transcriptionally activates growth-promoting genes. However, whether activation of TFII-I also directly affects the cell cycle profile is unknown. Here we show that under normal growth conditions, TFII-I is recruited to the cyclin D1 promoter and transcriptionally activates this gene. Most strikingly, upon cell cycle arrest resulting from genotoxic stress and p53 activation, TFII-I is ubiquitinated and targeted for proteasomal degradation in a p53- and ATM (ataxia

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Takaoka, Shohei, Marcos E. Jaso-Vera, and Xiangbo Ruan. "Disrupted Post-Transcriptional Regulation of Gene Expression as a Hallmark of Fatty Liver Progression." International Journal of Molecular Sciences 25, no. 20 (2024): 11054. http://dx.doi.org/10.3390/ijms252011054.

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It is known that both transcriptional and post-transcriptional mechanisms control messenger RNA (mRNA) levels. Compared to transcriptional regulations, our understanding of how post-transcriptional regulations adapt during fatty liver progression at the whole-transcriptome level is unclear. While traditional RNA-seq analysis uses only reads mapped to exons to determine gene expression, recent studies support the idea that intron-mapped reads can be reliably used to estimate gene transcription. In this study, we analyzed differential gene expression at both the exon and intron levels using two

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Davies, Kevin M., and Kathy E. Schwinn. "Transcriptional regulation of secondary metabolism." Functional Plant Biology 30, no. 9 (2003): 913. http://dx.doi.org/10.1071/fp03062.

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Plants produce secondary metabolites during development and in response to environmental stimuli such as light or pathogen attack. Transcriptional regulation provides the most important control point for the secondary metabolic pathways studied to date. In this article we review the data on the transcription factors that modulate this regulation. For the phenylpropanoid pathway, much is understood about both the specific sequences in the target genes (cis-elements) that are involved in responses to environmental and developmental stimuli, and the transcription factors involved. Most informatio

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Trotter, Kevin W., and Trevor K. Archer. "The BRG1 transcriptional coregulator." Nuclear Receptor Signaling 6, no. 1 (2008): nrs.06004. http://dx.doi.org/10.1621/nrs.06004.

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The packaging of genomic DNA into chromatin, often viewed as an impediment to the transcription process, plays a fundamental role in the regulation of gene expression. Chromatin remodeling proteins have been shown to alter local chromatin structure and facilitate recruitment of essential factors required for transcription. Brahma-related gene-1 (BRG1), the central catalytic subunit of numerous chromatin-modifying enzymatic complexes, uses the energy derived from ATP-hydrolysis to disrupt the chromatin architecture of target promoters. In this review, we examine BRG1 as a major coregulator of t

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Inazumi, Hideaki, and Koichiro Kuwahara. "NRSF/REST-Mediated Epigenomic Regulation in the Heart: Transcriptional Control of Natriuretic Peptides and Beyond." Biology 11, no. 8 (2022): 1197. http://dx.doi.org/10.3390/biology11081197.

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Reactivation of fetal cardiac genes, including those encoding atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), is a key feature of pathological cardiac remodeling and heart failure. Intensive studies on the regulation of ANP and BNP have revealed the involvement of numerous transcriptional factors in the regulation of the fetal cardiac gene program. Among these, we identified that a transcriptional repressor, neuron-restrictive silencer factor (NRSF), also named repressor element-1-silencing transcription factor (REST), which was initially detected as a transcriptional rep

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Kiik, Helen, Saumya Ramanayake, Michi Miura, Yuetsu Tanaka, Anat Melamed, and Charles R. M. Bangham. "Time-course of host cell transcription during the HTLV-1 transcriptional burst." PLOS Pathogens 18, no. 5 (2022): e1010387. http://dx.doi.org/10.1371/journal.ppat.1010387.

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The human T-cell leukemia virus type 1 (HTLV-1) transactivator protein Tax has pleiotropic functions in the host cell affecting cell-cycle regulation, DNA damage response pathways and apoptosis. These actions of Tax have been implicated in the persistence and pathogenesis of HTLV-1-infected cells. It is now known that tax expression occurs in transcriptional bursts of the proviral plus-strand, but the effects of the burst on host transcription are not fully understood. We carried out RNA sequencing of two naturally-infected T-cell clones transduced with a Tax-responsive Timer protein, which un

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Österlund, Tobias, Sergio Bordel, and Jens Nielsen. "Controllability analysis of transcriptional regulatory networks reveals circular control patterns among transcription factors." Integrative Biology 7, no. 5 (2015): 560–68. http://dx.doi.org/10.1039/c4ib00247d.

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Transcriptional regulation is the most committed type of regulation in living cells where transcription factors (TFs) control the expression of their target genes and TF expression is controlled by other TFs forming complex transcriptional regulatory networks that can be highly interconnected.

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Lozano-Velasco, Estefanía, Carlos Garcia-Padilla, Miguel Carmona-Garcia, et al. "MEF2C Directly Interacts with Pre-miRNAs and Distinct RNPs to Post-Transcriptionally Regulate miR-23a-miR-27a-miR-24-2 microRNA Cluster Member Expression." Non-Coding RNA 10, no. 3 (2024): 32. http://dx.doi.org/10.3390/ncrna10030032.

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Transcriptional regulation constitutes a key step in gene expression regulation. Myocyte enhancer factor 2C (MEF2C) is a transcription factor of the MADS box family involved in the early development of several cell types, including muscle cells. Over the last decade, a novel layer of complexity modulating gene regulation has emerged as non-coding RNAs have been identified, impacting both transcriptional and post-transcriptional regulation. microRNAs represent the most studied and abundantly expressed subtype of small non-coding RNAs, and their functional roles have been widely documented. On t

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Ohno, Yoshinori, Keita Saeki, Shin'ichiro Yasunaga, et al. "Transcription of the Geminin gene is regulated by a negative-feedback loop." Molecular Biology of the Cell 25, no. 8 (2014): 1374–83. http://dx.doi.org/10.1091/mbc.e13-09-0534.

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Geminin performs a central function in regulating cellular proliferation and differentiation in development and also in stem cells. Of interest, down-regulation of Geminin induces gene transcription regulated by E2F, indicating that Geminin is involved in regulation of E2F-mediated transcriptional activity. Because transcription of the Geminin gene is reportedly regulated via an E2F-responsive region (E2F-R) located in the first intron, we first used a reporter vector to examine the effect of Geminin on E2F-mediated transcriptional regulation. We found that Geminin transfection suppressed E2F1

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Cook, Andrew, Rebecca Stephens, Nadezda Fursova, Carson C. Chow, Dan Larson, and Yekaterina Miroshnikova. "Abstract 5641: Transcriptional regulation by nuclear deformation." Cancer Research 84, no. 6_Supplement (2024): 5641. http://dx.doi.org/10.1158/1538-7445.am2024-5641.

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Abstract Establishment and maintenance of cell identities requires transcriptional rewiring and modulation of three-dimensional genome organization. The nucleus is subject to constant mechanical forces, both intrinsic from the cytoskeleton and extrinsic, such as compression, confinement, and stretch. Recently, work from us and others implicate mechanical force, through activating biochemical signaling pathways as well as direct nuclear deformation, in remodeling nuclear architecture, chromatin state and global gene expression patterns. Thus, we hypothesize that mechanical force plays an import

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Georgitsi, Marianthi, Branka Zukic, Sonja Pavlovic, and George P. Patrinos. "Transcriptional regulation and pharmacogenomics." Pharmacogenomics 12, no. 5 (2011): 655–73. http://dx.doi.org/10.2217/pgs.10.215.

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Rosen, Evan D., Christopher J. Walkey, Pere Puigserver, and Bruce M. Spiegelman. "Transcriptional regulation of adipogenesis." Genes & Development 14, no. 11 (2000): 1293–307. http://dx.doi.org/10.1101/gad.14.11.1293.

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McGee, Sean, L. "AMPK and transcriptional regulation." Frontiers in Bioscience 13, no. 13 (2008): 3022. http://dx.doi.org/10.2741/2907.

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