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Dissertations / Theses on the topic 'Transcriptome'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Klevebring, Daniel. "On Transcriptome Sequencing." Doctoral thesis, KTH, Genteknologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-11446.

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This thesis is about the use of massive DNA sequencing to investigate the transcriptome. During recent decades, several studies have made it clear that the transcriptome comprises a more complex set of biochemical machinery than was previously believed. The majority of the genome can be expressed as transcripts; and overlapping and antisense transcription is widespread. New technologies for the interroga- tion of nucleic acids have made it possible to investigate such cellular phenomena in much greater detail than ever before. For each application, special requirements need to be met. The work
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2

Zachariadou, Christina. "Gingival Health Transcriptome." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1532533066167142.

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3

Nociti, Ricardo Perecin. "Transcrição em embriões bovinos produzidos in vitro /." Jaboticabal, 2018. http://hdl.handle.net/11449/157385.

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Orientador: Vera Fernanda Martins Hossepian de Lima<br>Resumo: O processo transcricional em embriões extremamente complexo, nosso trabalho estimou o impacto de perturbações nos processos de transcricionais, durante as fases de ativação do genoma embrionário sobre o desenvolvimento embrionário in vitro de embriões; analisamos dados de sequenciamento de rna (RNA-seq) depositados nos bancos públicos (GEO) desde o estágio de oóocito até o dia 19 do desenvolvimento embrionário; Isolamos e caracterizamos a massa celular interna (ICM) e a trofectoderma (TE) do sexo masculino e feminino, oriundos de u
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4

Schwalb, Björn. "Dynamic transcriptome analysis (DTA)." Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-147748.

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5

Werne, Solnestam Beata. "Interpreting the human transcriptome." Doctoral thesis, KTH, Genteknologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-158320.

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The human body is made of billions of cells and nearly all have the same genome. However, there is a high diversity of cells, resulted from what part of the genome the cells use, i.e. which RNA molecules are expressed. Rapid advances within the field of sequencing allow us to determine the RNA molecules expressed in a specific cell at a certain time. The use of the new technologies has expanded our view of the human transcriptome and increased our understanding of when, where, and how each RNA molecule is expressed. The work presented in this thesis focuses on analysis of the human transcripto
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6

Rosier, Florian. "Au-delà des études d'association à l'échelle du génome : étude transcriptomique et identification des variants régulateurs impliqués dans le développement du sepsis." Thesis, Aix-Marseille, 2019. http://www.theses.fr/2019AIXM0542.

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En 2017, l'Assemblée mondiale de la Santé et l'Organisation mondiale de la Santé ont fait du sepsis une priorité de santé mondiale en adoptant une résolution pour améliorer, prévenir, diagnostiquer et gérer le sepsis. Cette pathologie tue principalement des personnes déjà fragilisées. Il a été démontré que l'état du patient et la réponse immunitaire de l'hôte est primordiale dans le développement de la pathologie. Mon projet de thèse a tout d’abord consisté à caractériser la réponse transcriptionnelle de cellules du péritoine stimulées au LPS dans un modèle murin du sepsis. Par ailleurs, j’ai
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7

Loe-mie, Yann. "Contribution bioinformatique à l' analyse du transcriptome humain." Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM4002/document.

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Dans la première partie j'ai analysé des jeux de données de RNA-seq de transcriptome de petits ARNs disponibles dans les bases de données publiques. J'y ai observé 2 points intrigants : - une grande partie des lectures (bien que courtes) ne peux pas être alignée sur le génome de référence sans discordance et cette fraction non-alignable est parfois majoritaire. - de nombreuses lectures ont des tailles autours de 15-18nt qui ne correspondent à aucun type de petits ARNs connues, cette fraction est également majoritaires dans certains cas. Ces expériences sont souvent conçues pour la détection de
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8

Borsari, Beatrice 1992. "Epigenetic regulation of the transcriptome." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671429.

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We have monitored the transcriptome and the epigenome of human pre-B cells transdifferentiating into macrophages. Analysis of these data provides a general framework to understand the relationship between gene expression and chromatin. We have observed widespread uncoupling of gene expression and epigenetic features during transdifferentiation, with several genes characterized by unvaried chromatin state throughout the process, irrespective of changes in gene expression. Nevertheless, we report a strong association between transcription and chromatin marking of promoter regions at the time of
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9

Natarajan, Sripriya 1978. "Defining the human endothelial transcriptome." Thesis, Massachusetts Institute of Technology, 2005. http://hdl.handle.net/1721.1/33082.

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Thesis (S.M.)--Harvard-MIT Division of Health Sciences and Technology, 2005.<br>Includes bibliographical references (leaves 91-100).<br>Advances in microarray technology facilitate the study of biological systems at a genome-wide level. Meaningful analysis of these transcriptional profiling studies, however, demands the concomitant development of novel computational techniques that take into account the size and complexity of the data. We have devised statistical algorithms that use replicate microarrays to define a genome-wide expression profile of a given cell type and to determine a list of
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10

Meng, Arnaud. "Étude de la symbiose dans le plancton marin par une approche transcriptome et méta-transcriptome." Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066478/document.

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Les relations symbiotiques entre organismes sont essentielles pour l’évolution de la bio- diversité et le fonctionnement des écosystèmes. En milieu terrestre ou en milieu marin benthique les symbioses sont assez bien décrites. Si dans le plancton marin, les relations entre hôtes hétérotrophes et symbiontes photosynthétiques sont des phénomènes observés dès le 19ème siècle, les mécanismes fonctionnels qui régissent ces symbioses restent largement inconnus. C’est le cas de la symbiose entre certaines espèces de radiolaires et leurs symbiontes dinoflagellés. Il s’agit d’un mode
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11

Meng, Arnaud. "Étude de la symbiose dans le plancton marin par une approche transcriptome et méta-transcriptome." Electronic Thesis or Diss., Paris 6, 2017. http://www.theses.fr/2017PA066478.

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Les relations symbiotiques entre organismes sont essentielles pour l’évolution de la bio- diversité et le fonctionnement des écosystèmes. En milieu terrestre ou en milieu marin benthique les symbioses sont assez bien décrites. Si dans le plancton marin, les relations entre hôtes hétérotrophes et symbiontes photosynthétiques sont des phénomènes observés dès le 19ème siècle, les mécanismes fonctionnels qui régissent ces symbioses restent largement inconnus. C’est le cas de la symbiose entre certaines espèces de radiolaires et leurs symbiontes dinoflagellés. Il s’agit d’un mode
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12

Jousset, Agnès. "analyse génomique et transcriptomique de bactéries productrices de carbapénèmases." Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS527.

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Le combat contre les infections bactériennes reste un enjeu majeur de santé publique notamment avec la dissémination des Entérobactéries productrices de carbapénèmases, capables d’hydrolyser l’ensemble des β-lactamines. On assiste à l’émergence de certains clones épidémiques, se distinguant par leur distribution mondiale, leur forte transmissibilité et leur capacité à persister chez les patients. L’exemple le plus parlant est le cas du clone de Klebsiella pneumoniae appartenant au « sequence type » (ST) 258 et responsable de la diffusion mondiale de la carbapénèmase KPC (Klebsiella Pneumoniae
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13

Soares, VitÃria VirgÃnia MagalhÃes. "IdentificaÃÃo, validaÃÃo e anotaÃÃo funcional de marcadores microssatÃlites em genÃtipos de cajueiro anÃo-precoce (Anacardium occidentale var. nanum) utilizando dados de rna-seq." Universidade Federal do CearÃ, 2016. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=17697.

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CoordenaÃÃo de AperfeiÃoamento de Pessoal de NÃvel Superior<br>O cajueiro (Anacardium occidentale L.) à uma planta nativa do Brasil com grande valor comercial. Isso contribui com a geraÃÃo de milhares de empregos diretos e indiretos, especialmente na RegiÃo Nordeste, em Ãpoca de estiagem. Programas de melhoramento genÃtico vem selecionando cultivares de cajueiro melhores adaptados ao ambiente semiÃrido a fim de colocÃ-lo em um mercado cada vez mais competitivo. A busca por marcadores microssatÃlites pode auxiliar os programas de melhoramento no que diz respeito ao acesso à diversidade genÃtica
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14

Troca, Heitor Madalena da Silva. "Perfil de expressão gênica de fêmeas de Aedes aegypti durante o cortejo e acasalamento." Botucatu, 2020. http://hdl.handle.net/11449/192636.

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Orientador: Paulo Eduardo Martins Ribolla<br>Resumo: O Aedes aegypti é o mosquito mais sinantrópico e antropofílico da família Culicidae. Esta espécie sempre coabita com os seres humanos e é extremamente oportunista. A dispersão vetorial está diretamente relacionada à capacidade das fêmeas de encontrar um parceiro com sucesso em um cenário urbano geralmente irregular. No presente trabalho, investigamos alterações transcricionais em fêmeas de Ae. aegypti durante o processo de cortejo e após o acasalamento. Observamos uma alteração substancial na expressão gênica desencadeada logo após o contato
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15

Textoris, Julien. "Réponse à l'infection : apport du transcriptome." Phd thesis, Université de la Méditerranée - Aix-Marseille II, 2011. http://tel.archives-ouvertes.fr/tel-00723077.

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Avant propos L'objectif de cette thèse est d'explorer l'inflammation et l'infection au niveau du transcriptome, à l'aide de la technologie des puces à ADN. Pour cela, nous avons dans un premier temps travaillé sur des données publiques. Nous avons construit une base de données de signatures transcriptionnelles annotées, et développé un logiciel modulaire d'analyse. Ce logiciel permet d'explorer aisément les données publiques en effectuant des recherches par nom de gène ou par mots-clés. Nous avons ensuite exploré la modulation temporelle de l'expression des gènes du parenchyme pulmonaire dans
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16

Wirta, Valtteri. "Mining the transcriptome - methods and applications." Doctoral thesis, Stockholm : School of Biotechnology, Royal Institute of Technology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4115.

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17

Babic, Ana [Verfasser]. "Profiling of synaptic transcriptome / Ana Babic." Berlin : Freie Universität Berlin, 2017. http://d-nb.info/1122586566/34.

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18

Zhang, Yonghua. "Studies of the adipose tissue transcriptome." Thesis, Université Laval, 2008. http://www.theses.ulaval.ca/2008/25907/25907.pdf.

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19

Valekunja, Utham Kashyap. "The mammalian circadian transcriptome and epigenome." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.709142.

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20

Wang, Jing. "New views on the Drosophila transcriptome." Thesis, University of Glasgow, 2014. http://theses.gla.ac.uk/5459/.

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Drosophila is a valuable experimental organism can be used as a reverse genetics model. Drosophila Malpighian (renal) tubules are important epithelial tissue in which to study transport mechanisms. RNA-seq has been chosen to investigate Drosophila Malpighian (renal) tubules to identify novel genes following a three- way comparison between three popular transcriptome profiling methods. Two types of novel gene have been found in Drosophila tubules, coding genes and noncoding genes. Reverse genetics has been applied to identify novel coding gene function in Drosophila tubules. Three-way analysis
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21

Atkinson, S. R. "The fission yeast non-coding transcriptome." Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1457868/.

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Long non-coding RNAs (lncRNAs) are emerging as important regulators of gene expression, although it remains unclear to what extent they contribute overall to the information flow from genotype to phenotype. Using strand-specific RNAsequencing, I identify thousands of novel unstable, or cryptic, lncRNAs in Schizosaccharomyces pombe. The nuclear exosome, the RNAi pathway and the cytoplasmic exonuclease Exo2 represent three key pathways regulating lncRNAs in S. pombe, defining the overlapping classes of CUTs, RUTs and XUTs, respectively. The nuclear exosome and the RNAi pathway act cooperatively
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22

Gunawardana, Yawwani P. "Modelling at the transcriptome-proteome interface." Thesis, University of Southampton, 2015. https://eprints.soton.ac.uk/386877/.

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In high-throughput experimental biology, it is widely acknowledged that mRNA expression levels and the corresponding protein abundances are jointly analysed to observe the relationship between these two omic measurements. While some experiments have shown a good correlation between transcriptome and proteome for some species under different conditions, such correlation values are not universal due to post-transcriptional and post-translational regulations. Thus, bridging the gap between transcriptome and proteome measurements allow us to uncover useful biological insights of the above regulati
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23

Shamim, Baubak. "Concurrent exercise from training to transcriptome." Phd thesis, Australian Catholic University, 2020. https://acuresearchbank.acu.edu.au/download/4116399d7c75edb34b93aa0f45f835667d00b358764a4a938e474d5b8ff63ca7/2892125/Shamim_2020_Concurrent_exercise_from_training_to_transcriptome.pdf.

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The principle of training specificity dictates that adaptations to exercise training are specific to the mode, frequency, and duration of exercise performed, and result in distinct and divergent skeletal muscle phenotypes. Strength-based training promotes skeletal muscle hypertrophy and maximal force-generating capacity while endurance-based training improves skeletal muscle oxidative capacity and cardiorespiratory fitness. Previous research has suggested the capacity of skeletal muscle to adapt to strength and endurance training when performed simultaneously (i.e., concurrent exercise trainin
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24

Scantland-Marchand, Sara-Myriam. "Transcriptome et métabolisme de l'ovocyte bovin." Doctoral thesis, Université Laval, 2014. http://hdl.handle.net/20.500.11794/25530.

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Durant la croissance, les ovocytes emmagasinent des quantités importantes d’ARNm maternel dans leur cytoplasme. Ces ARNm pourront plus tard être traduit en protéines afin de soutenir la maturation ovocytaire et le développement précoce et ce, jusqu’à l’activation du génome de l’embryon qui est une étape cruciale du développement. Trois catégories d’ARNm peuvent être distinguées durant cette période : les ARNm emmagasinés, les ARNm en voie de traduction (ARNm polyribosomaux) et les ARNm voués à la dégradation. De ces trois catégories, seuls les ARNm polyribosomaux ont un impact direct sur la ph
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25

Östman, Josephine. "The fertile ovary transcriptome and proteome." Thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-447785.

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The Human Protein Atlas is an open-source database containing information about protein expression and location in the human cells,tissues and organs. The aim is to map all the proteins in humans using various biotechnology techniques such as antibody-based imaging, andRNA sequencing etc. Based on previous transcriptome analysis, 173 genes were shown to have an elevated expression in ovary compared to all other major tissue types in the human body. There is however no information regarding the expression in ovary during the reproductive years versus the post-menopausal years. In this thesis, t
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Fonseca, Larissa Fernanda Simielli [UNESP]. "Expressão gênica diferencial em tecido muscular de bovinos Nelore divergentes para qualidade de carne." Universidade Estadual Paulista (UNESP), 2016. http://hdl.handle.net/11449/137800.

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Submitted by la_simielli@yahoo.com.br (la_simielli@yahoo.com.br) on 2016-04-05T13:12:40Z No. of bitstreams: 1 TESE_LARISSA_FERNANDA_SIMIELLI_FONSECA.pdf: 1971633 bytes, checksum: 177f6a3044467459f559bbf217ba550f (MD5)<br>Approved for entry into archive by Ana Paula Grisoto (grisotoana@reitoria.unesp.br) on 2016-04-06T20:32:27Z (GMT) No. of bitstreams: 1 fonseca_lfs_dr_jabo.pdf: 1971633 bytes, checksum: 177f6a3044467459f559bbf217ba550f (MD5)<br>Made available in DSpace on 2016-04-06T20:32:27Z (GMT). No. of bitstreams: 1 fonseca_lfs_dr_jabo.pdf: 1971633 bytes, checksum: 177f6a3044467459f559
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Lesluyes, Tom. "Remodelage génomique des sarcomes pléomorphes : caractérisation transcriptomique et agressivité tumorale." Thesis, Bordeaux, 2019. http://www.theses.fr/2019BORD0074.

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Les sarcomes pléomorphes sont des tumeurs mésenchymateuses rares caractérisées par de nombreux remaniements chromosomiques. Leur processus d’oncogenèse reste encore mal compris, aucune altération génétique motrice de l’initiation tumorale n’a pu être identifiée de façon récurrente et spécifique à ce jour. Les travaux que j’ai réalisés durant ma thèse avaient pour but de mieux comprendre la biologie de ces tumeurs, notamment les conséquences transcriptomiques de leur remodelage génomique.Nous avons caractérisé les transcrits de fusion exprimés dans ces tumeurs par séquençage haut-débit (RNA-seq
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28

Agaton, Charlotta. "Transcriptome and Proteome Analysis using Signature Tags." Doctoral thesis, KTH, Biotechnology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-3678.

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<p>With the full sequence of the human genome now available, anexciting era in biomedical research has started. The sequenceprovides information about all our genes and greatly increasesthe scope to compare genetic activities in different cells, toanalyze genetic variation between individuals and betweendifferent species and, most importantly, to investigatesystematically the whole genome in a gene-by-gene manner, andthus increase our understanding of gene function.</p><p>This thesis describes studies in which developments weremade in several areas of functional genomics. Messenger RNAlevels w
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au, M. King@murdoch edu, and Michaela King. "The phosphite responsive transcriptome of phytophthora cinnamomi." Murdoch University, 2007. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20080526.104656.

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Phosphite has been used to effectively control the soil borne plant pathogen Phytophthora cinnamomi in many horticultural crops, forest trees and natural ecosystems. However, the molecular mechanisms behind phosphite action on this pathogen are poorly understood. Several studies have shown that phosphite inhibits growth and zoospore production of P. cinnamomi and in addition induces significant physiological and metabolic changes in the mycelium. As an approach to understanding the mechanisms and relevance of these changes in the pathogen, the effect of phosphite on gene expression was invest
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Moertel, Luke Paul Frank, and mobileluke@hotmail com /. Luke Moertel@qimr edu au. "Microarray Analysis of the Schistosoma japonicum Transcriptome." Central Queensland University. Chemical and Biomedical Sciences, 2007. http://library-resources.cqu.edu.au./thesis/adt-QCQU/public/adt-QCQU20070705.120939.

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Schistosomiasis, a disease of humans caused by helminth parasites of the genus Schistosoma, kills 200 to 500 thousand people annually, endangering over 600 million people world-wide with 200 million people infected in 2003 [1, 2]. Three species of schistosome are primarily responsible for human infections, namely, Schistosoma haematobium, endemic to Africa, India, and the Middle East, S. mansoni, endemic to Africa / South America, and S. japonicum endemic to China and the Philippines [3]. The major pathological effects of schistosomiasis result from the deposition of parasite ova in human tiss
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31

Habermann, Jens Karsten. "Colorectal cancer : genome, transcriptome, and proteome dynamics /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-411-2/.

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Larsson, Ola. "Transcriptome studies of cell-fate and aging /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-296-9/.

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Ono, Jasmine. "Transcriptome evolution in black cottonwood (Populus trichocarpa)." Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/39879.

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In 1975, King and Wilson proposed that gene expression variation can play a role in the evolution of phenotypic variation since the variation in nature could not be explained by variation in protein coding sequences alone. When a mutation which causes a change in gene expression is introduced in to a population, either selection or neutral drift can act on it. When this mutation causes no change in fitness of the organism, it will be affected by neutral drift. The bounds for neutral drift are thought to be set by stabilizing selection. If the mutation is beneficial to the organism, it will be
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Johnston, C. E. "Bioinformatics exploration of the transcriptome vol 1." Thesis, University of Essex, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.499795.

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35

Uebbing, Severin. "On the Evolution of the Avian Transcriptome." Doctoral thesis, Uppsala universitet, Evolutionsbiologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-259487.

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Change in gene expression is a powerful tool for evolution, because seemingly small expression changes can contribute important steps towards adaptation without necessarily affecting the whole organism. There is still much to learn about how gene expression evolves on genome- and population-wide levels, especially in non-model organisms. This thesis addresses some important questions in gene expression evolution via the quantitative measurement of RNA and protein levels in birds. First, I confirmed the state of incomplete dosage compensation in birds by sequencing the transcriptome of collared
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Bergeron, Claudia. "Transcriptome du bactériophage DT1 de Streptococcus thermophilus." Thesis, Université Laval, 2006. http://www.theses.ulaval.ca/2006/24042/24042.pdf.

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Kostadima, Myrto Areti. "Analysis of the haematopoietic transcriptome in development." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708506.

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Vickovic, Sanja. "Transcriptome-wide analysis in cells and tissues." Doctoral thesis, KTH, Genteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-199447.

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High-throughput sequencing has greatly influenced the amount of data produced and biological questions asked and answered. Sequencing approaches have also enabled rapid development of related technological fields such as single-cell and spatially resolved expression profiling. The introductory parts of this thesis give an overview of the basic molecular and technological apparatus needed to analyse the transcriptome in cells and tissues. This is succeeded by a summary of present investigations that report recent advancements in RNA profiling. RNA integrity needs to be preserved for accurate ge
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Liu, Zhe. "Machine annotation of genome and transcriptome data." Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/17626.

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One of the key research topics of post-genome study is annotation of the gene with regards to specific function and biological processes. This can help us to understand the precise role that a gene or a group of genes carries. In this thesis, I developed techniques to automatically annotate genes on single gene and a group of genes levels. It is shown that these techniques improve our understanding of biological systems/diseases, and will aid drug discovery. In the first project, I attempted to achieve precise annotation for single genes. In the second and third projects, I performed annotatio
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Riva, Alessandra. "Un regard critique sur l'analyse du transcriptome." Evry-Val d'Essonne, 2004. http://www.theses.fr/2004EVRYA008.

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Le travail analyse la contribution des expériences de transcriptome à la biologie in silico et étudie leur complémentarité avec les méthodes classiques de bioinformatique. Trois études comparatives ont été réalisées et les conclusions sont les suivantes : Quand il existe une base expérimentale solide, la génomique (associée au data mining) peut être employée avec succès pour répondre aux questions. Le transcriptome apporte des informations secondaires. L'analyse du transcriptome ne permet pas de résoudre les problèmes dus à l'imprécision des informations génomiques. L'analyse du transcriptome
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Le, Bouter Sabrina. "Etude du transcriptome des canaux ioniques cardiaques." Nantes, 2004. http://www.theses.fr/2004NANT19VS.

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Afin de mieux cerner les mécanismes qui régulent le transcriptome ionique cardiaque, c'est-à-dire l'ensemble des canaux exprimés dans le coeur, des puces à ADN, constituées de l'ensemble des canaux ioniques et de leurs régulateurs ont été développées au sein du laboratoire. Au cours de ce travail, cet outil a été utilisé pour établir une corrélation entre les modifications cardiaques induites par une disrégulation du statut thyroi͏̈dien et le transcriptome ionique. Nous avons pu mettre en évidence qu'une hypothyroi͏̈die conduisait à la sous-expression des canaux majoritairement responsables de
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Oldham, Michael Clark. "Transcriptome organization in human and chimpanzee brains." Diss., Restricted to subscribing institutions, 2009. http://proquest.umi.com/pqdweb?did=1872073991&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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43

Le, Bouter Sabrina Demolombe Sophie. "Etude du transcriptome des canaux ioniques cardiaques." [S.l.] : [s.n.], 2004. http://theses.univ-nantes.fr/thesemed/DOClebouter.pdf.

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44

King, Michaela. "The phosphite responsive transcriptome of phytophthora cinnamomi." Thesis, King, Michaela (2007) The phosphite responsive transcriptome of phytophthora cinnamomi. PhD thesis, Murdoch University, 2007. https://researchrepository.murdoch.edu.au/id/eprint/132/.

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Phosphite has been used to effectively control the soil borne plant pathogen Phytophthora cinnamomi in many horticultural crops, forest trees and natural ecosystems. However, the molecular mechanisms behind phosphite action on this pathogen are poorly understood. Several studies have shown that phosphite inhibits growth and zoospore production of P. cinnamomi and in addition induces significant physiological and metabolic changes in the mycelium. As an approach to understanding the mechanisms and relevance of these changes in the pathogen, the effect of phosphite on gene expression was inve
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45

King, Michaela. "The phosphite responsive transcriptome of Phytophthora cinnamomi /." King, Michaela (2007) The phosphite responsive transcriptome of phytophthora cinnamomi. PhD thesis, Murdoch University, 2007. http://researchrepository.murdoch.edu.au/132/.

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Phosphite has been used to effectively control the soil borne plant pathogen Phytophthora cinnamomi in many horticultural crops, forest trees and natural ecosystems. However, the molecular mechanisms behind phosphite action on this pathogen are poorly understood. Several studies have shown that phosphite inhibits growth and zoospore production of P. cinnamomi and in addition induces significant physiological and metabolic changes in the mycelium. As an approach to understanding the mechanisms and relevance of these changes in the pathogen, the effect of phosphite on gene expression was inve
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46

Kilaru, Aruna. "Changes in Avocado Transcriptome During Fruit Maturation." Digital Commons @ East Tennessee State University, 2014. https://dc.etsu.edu/etsu-works/4774.

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Martini, Paolo. "Dissecting the transcriptome complexity with bioinformatics tools." Doctoral thesis, Università degli studi di Padova, 2012. http://hdl.handle.net/11577/3422923.

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Bioinformatics has acquired a lot of importance especially with the advent of genomic approaches. The large amount of data produced by ``omics'' experiments requires appropriate frameworks to handle, store and mine the information and to derive appropriate work hypotheses. Transcriptome is defined as the whole amount of RNA molecules produced by a cell that provides the bridge between the genome and proteins. RNA molecules can be divided in two major classes: protein coding RNAs or messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs). While the first class has been the most studied in the last
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48

Pommier, Janine. "Etude de facteurs influençant la susceptibilité de l'hôte au paludisme : Effet de facteurs génétiques et de l' état inflammatoire." Thesis, Aix-Marseille, 2014. http://www.theses.fr/2014AIXM4003.

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Mon travail de thèse a porté sur l'étude des facteurs influençant le devenir de l'infection palustre. Une étude de liaison génétique basée sur des marqueurs répartis sur l'ensemble du génome nous a permis de mettre en évidence la liaison génétique de la région chromosomique 17p11-p13 avec la parasitémie. Nous avons étudié les variations génétiques des gènes HS3ST3A1 et HS3ST3B1 du chromosome 17p12 humain car ces gènes pourraient influencer l'infection de cellules humaines par le Plasmodium. Nous avons ainsi observé la liaison génétique de certain SNP de ces gènes avec la parasitémie. Les antic
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Benoit-Pilven, Clara. "Analyse de l’épissage alternatif dans les données RNAseq : développement et comparaison d’outils bioinformatiques." Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE1280/document.

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L'épissage alternatif est un processus biologique qui génère la diversité du protéome malgré le nombre limité de gène. Ce mécanisme régule à la fois les gènes de manières qualitatives (isoformes exprimées) mais aussi quantitatives (niveau d'expression). Avec le développement des technologies de séquençage à haut débit, il est maintenant possible d'étudier à large échelle les aspects quantitatif et qualitatif du transcriptome avec une même expérience (RNA-seq). Durant ma thèse, j'ai développé une nouvelle méthode d'analyse de l'épissage alternatif dans les données RNA-seq. J'ai également partic
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Coqueiro, Danila Souza Oliveira 1984. "Expressão gênica diferencial induzida por eliciadores (quitosana e ácido salicílico) nos patossistemas citros-Xanthomonas citri subsp. citri e citros-Xylella fastidiosa = Differential gene expression induced by elicitors (chitosan and salicylic acid) in citrus-Xanthomonas citri subsp. citri and citrus-Xylella fastidiosa pathosystems." [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/314472.

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Orientadores: Marcos Antonio Machado, Alessandra Alves de Souza<br>Tese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia<br>Made available in DSpace on 2018-08-24T04:53:23Z (GMT). No. of bitstreams: 1 Coqueiro_DanilaSouzaOliveira_D.pdf: 3034667 bytes, checksum: 7ce135c75da10c6b26032ec285344dc5 (MD5) Previous issue date: 2013<br>Resumo: Avaliou-se as alterações transcricionais em laranja 'Pera' (Citrus sinensis L. Osb.) promovidas por quitosana (CHI) e ácido salicílico (SA), utilizando RNA-seq, e o efeito destes compostos no controle do cancro cítrico (Xanthomonas citri
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