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Dissertations / Theses on the topic 'Transdermal Drug Delivery System (TDDS)'

Author: Grafiati
Published: 7 June 2025
Last updated: 2 August 2025

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1

Zucchini, Lorenzo. "Microaghi e Micropompe per Dispositivi TDDS." Bachelor's thesis, Alma Mater Studiorum - Università di Bologna, 2019. http://amslaurea.unibo.it/18627/.

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I Sistemi ad Infusione di Farmaco Transdermica (TDDS) sono estremamente promettenti ed in rapida evoluzione negli ultimi due decenni. La terza ed ultima generazione sfrutta le tecnologie produttive e i materiali tipici dei MEMS, per questo sono considerabili come facenti parte della categoria BioMEMS, cioè sistemi micro-elettromeccanici applicati alla clinica e alla medicina. Fra i più notevoli vantaggi vi sono la sicurezza del trattamento, le migliori capacità terapeutiche a parità di dose di farmaco, la regolazione automatica e tempo-dipendente del rilascio anche seguendo un feedback biologi
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2

Roxhed, Niclas. "A Fully Integrated Microneedle-based Transdermal Drug Delivery System." Doctoral thesis, Stockholm : Kungliga Tekniska högskolan, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-4484.

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3

Zeng, Jianming. "Constrained crystallization and depletion in the polymer medium for transdermal drug delivery system." Diss., Georgia Institute of Technology, 2004. http://hdl.handle.net/1853/5102.

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Transdermal drug delivery systems (TDS) are pharmaceutical devices that are designed to deliver specific drugs to the human body by diffusion through skin. The TDS effectiveness suffers from crystallization in the patch when they are kept in storage for more than two years. It has been reported that there are two types of crystals in the patch: needle and aggregate, and growth of drug crystals in TDS generally occurs only in the middle third of the polymer layer. In our study, fluorescence microscopy, EDS (SEM) and Raman microspectroscopy were used to further characterize the crystals. The res
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4

Van, Dyk Christina Petronella. "Transdermal delivery of 5-Fluorouracil with PheroidTM technology / C.P. van Dyk." Thesis, North-West University, 2008. http://hdl.handle.net/10394/1905.

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5

Talbi, Yassine. "Conception d'un patch transdermique intelligent pour le monitoring et l'aide à la prise de médicament." Thesis, Toulouse, INSA, 2018. http://www.theses.fr/2018ISAT0005/document.

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La surveillance personnalisée est une ambition émergente pour les technologies de la santé qui répond aux besoins des patients et des professionnels de santé. L'objectif de ce travail est d'aller jusqu’aux soins, en utilisant un actionneur télécommandé pour mettre en œuvre automatiquement une prescription médicamenteuse. Un système transdermique intelligent est conçu, sous la forme d’un patch, pour administrer de manière contrôlée des médicaments. Des expérimentations sont réalisées pour démontrer l’intérêt des techniques d’aide à la diffusion en termes de contrôle et d’amélioration de la quan
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6

Tsai, Chen-Yi, and 蔡甄憶. "Transdermal drug delivery systems (TDDS) inspired by geckos and houseflies." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/bckurr.

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碩士<br>國立中興大學<br>生醫工程研究所<br>100<br>In order to achieve their adhesion between the pad and smooth wall surface, the insect houseflies can be acquired through secreting an oily layer from their micron pad. In this thesis, we combine the character of wet adhesive attachment with principle of transdermal drug delivery systems (TDDS) to create a biomimetic drug releases tape which can attach to a variety of surfaces. At first, we constructed a micro/nano pillars containing tape platform by use of polydimethylsiloxane (PDMS) polymer. And then the compatibilities between platform and steroids or non-s
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7

Kuo, Chan-Hsuan, and 郭蟬瑄. "Estimation the transdermal drug delivery efficiency of the handheld liquid drug delivery system." Thesis, 2018. http://ndltd.ncl.edu.tw/handle/kfnx33.

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碩士<br>國立臺灣科技大學<br>醫學工程研究所<br>106<br>Drug permeation through the skin is usually limited by the stratum corneum in epidermis. In this study, the efficacy of a hand-held liquid drug delivery system for transdermal drug delivery will be evaluated. GNT GoldMedTM handheld liquid drug delivery system is a needle-free and low pressure of gas-powered injection system which can be used for transdermal biomaterials or drugs delivery. This study is mainly to assess the gas pressure, gas inflation time, flux and penetration depth of transdermal drug delivery by using this hand-held liquid drug delivery sy
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8

Wu, Pao-Chu, and 吳寶珠. "Development and Evaluation of Captopril Transdermal Drug Delivery System." Thesis, 1997. http://ndltd.ncl.edu.tw/handle/26701259472765658253.

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博士<br>高雄醫學院<br>藥學研究所<br>85<br>Captopril 升壓素轉化酵素抑制劑 (Inhibitor of angiotensin converting enzyme, ACE inhibitor) 是一具獨特作用機轉之抗高血壓治 療劑，對各種不同程度的高血壓均有良好的治療效果；而且比較不會產生 一般降壓劑經常產生之副作用如姿勢性低血壓、眩暈、頭痛、心悸及便秘 等症狀；故本研究以 Captopril 為模式藥來研製其經皮輸藥製劑。 本文首先建立適當體外穿透實驗之動物模式，結果是以經兔腹皮之穿透速 率較為適當(約為經人胸部皮膚穿透速率的 4.8 倍)，可用來評估各處方 之異同。再評估不同 pH 值緩衝溶液對 Captopril (pKa1 3.7 和 pKa2 9.8) 溶解度、油水分配係數及穿透係數之影響，結果顯示：溶液在 pH 值 5.0 時，Captopril 之油/水分佈係數 (Distribution coefficient) 及穿透係數(Permeabi
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9

Chen, YU-Ru, and 陳鈺如. "The formulation study of aqueous transdermal drug delivery system." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/46692084755526845556.

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碩士<br>中國醫藥學院<br>藥物化學研究所<br>91<br>Polyacrylate is used as the basic frame of transdermal drug delivery system in this study. It was mixed with several aqueous polymers to create a drug-in-adhesive system in sustained release medication. The aqueous polymers evaluated were: Metolose 90SH 15000, Pharmacoat 615, sodium CMC, Carbapol, Metolose 90SH 4000, PVP K30, and PVP K90D. When polyacrylate was mixed with different concentration of aqueous polymers and were applied on patches, the adhesive forces decrease as concentration ratio of aqueous polymers increased. These formulations of mat
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10

Maddheshiya, Sanjeet Kumar. "A study on ultrasound based transdermal drug delivery system." Thesis, 2013. http://ethesis.nitrkl.ac.in/4639/1/211BM1214.pdf.

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The development of an ultrasound based Transdermal drug delivery device (or sonophoresis) has received increased attention over the past few years. Meaningful enhanced carrying of model drugs such as mannitol and insulin has been determined using commercial sonicators. However, its practical use is hampered by its large size and weight of the common ultrasound transducer devices. In this project work, a remote controlled drug delivery system (sonophoresis device) with a flat flextensional ultrasound transducer was proposed. It is clearly known that low frequency ultrasound can be used to enhan
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11

Lin, Chien Ho, and 林建和. "Research & Development of Transdermal Drug Delivery System of Clonidine-Antihypertension Drug." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/12861584571948620199.

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碩士<br>東海大學<br>化學工程學系<br>84<br>This thesis project is to develop a transdermal drug delivery systemfor the treatment of antihypertension. Matrix diffusion-controlled systemwas chosen as the patch design due to its simplicity and cost effectiveness.The system consists of polymer matrix-Eudragit NE 30D and Eudragit RS 30D,model drug- Clonidine HCl, and hydrophilic adhesive-Plastoid E 35L. The in- vitro assessment of the selected transdermal patches was performed by employingdissolution, skin p
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12

林應群. "Design and development of Buprenorphine transdermal drug delivery system(I)." Thesis, 1991. http://ndltd.ncl.edu.tw/handle/76953073853447202780.

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13

Hsieh, Chin-Hsiung, and 謝錦雄. "The Development of Transdermal Drug Delivery System for Beta-Thalassaemia Major." Thesis, 2006. http://ndltd.ncl.edu.tw/handle/33450550369343563604.

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碩士<br>國立臺灣大學<br>醫學工程學研究所<br>94<br>The ultimate goal of this study is to help thalassemia major patients, who chronically require blood transfusions to keep alive. However, such long-term transfusions will lead to the accumulation of trivalent iron and bring about an iron overload condition. To treat iron overload, the patients usually receive intravenous or subcutaneous infusion of deferoxamine mesylate (DFO) regularly. The high costs of the drug, pump, and infusion materials, as well as the side effects, limit its acceptability and utility. For this reason, we hope to be able to change the me
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14

Wu, Shian Min, and 吳先民. "The Optimization for Iontophoretic Transdermal Drug Delivery System with Response Surface Method." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/45572326141065827330.

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15

Vinaya, Kumar K. B. "Design, Development and Performance Study of Microneedle & Micropump-based Transdermal Drug Delivery System." Thesis, 2015. http://etd.iisc.ac.in/handle/2005/4092.

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Transdermal drug delivery is the most preferred drug delivery method, due to its high efficiency and less side effects. In conventional transdermal drug delivery, the delivery of macromolecular drugs (ex: Insulin, vaccines etc.) is limited by skin barrier. Several possible approaches have been proposed to overcome this limitation (chemical, electrical, ultrasound, microneedle etc.). Among these, the microneedle approach is considered as one of the best method to improve the effective delivery of drug. These microneedles penetrate into the outermost skin layers namely stratum corneum and epider
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16

Fang, Jia-You, and 方嘉佑. "Development and Evaluation on Transdermal Drug Delivery System of Capsaicin, Nonivamide and Sodium Nonivamide Acetate." Thesis, 1996. http://ndltd.ncl.edu.tw/handle/40987806174803134399.

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博士<br>高雄醫學院<br>藥學研究所<br>84<br>Nonivamide (NVA) 及 Sodium Nonivamide Acetate (SNA) 皆為番椒 晶素 (capsaicin)之合成同類物, capsaicin 是茄科番椒屬植物的主要有 效抽取成份, 其在心血管, 呼吸及神經系統皆有顯著的藥理活性, 但是由 於 capsaicin 具有很強烈的辛辣感覺因此限制了其於臨床上的應用. 除 此之外, NVA 保留了番椒晶素之藥理活性及辛辣刺激性, 而 SNA 為 NVA 經結構修飾後所得之不具辛辣性的鈉鹽產物, SNA 是以 bromoacetic acid 和 NVA 反應而得之新潁化合物. 番椒晶素類藥物之抗傷痛活性 會由於投與方式的不同而有很大的差別, 之前的文獻曾指出番椒晶素經由 皮下注射及腹腔注射之抗傷痛活性明顯地較口服投與方式為強, 口服投與 方式的低生體可用率是由於體內首渡效應發生的原因, 因此可避免首渡效 應發生的經皮投與方式推測很適合於 caps
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17

Yuan, Xudong. "Enhanced transdermal drug delivery of nsaids using eutectic formation and a two-phase liquid system." 2003. http://purl.galileo.usg.edu/uga%5Fetd/yuan%5Fxudong%5F200308%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2003.<br>Directed by Anthony C. Capomacchia. Includes articles submitted to The journal of pharmaceutical development and technology, The international journal of pharmaceutics, The journal of pharmaceutical sciences, and The journal of drug development and industrial pharmacy, and an article published in The journal of analytical letters. Includes bibliographical references.
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18

Chin-YuChung and 鍾覲羽. "PCOX Microneedles Containing Gelatin Microspheres as a Dual-Drug Release System for Transdermal Delivery of Hydrophilic and Lipophilic Drugs." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/60267786469584282636.

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碩士<br>國立成功大學<br>化學工程學系<br>104<br>This study reports embeddable polycarbonate-co-polyoxalate (PCOX) microneedles (MNs) containing crosslinked gelatin microspheres (MPs) as a dual- drug transdermal delivery system for hydrophilic and hydrophobic drugs. In this system, hydrophobic model drugs, rhodamine 6G (Rh6G), was encapsulated within the MNs; whereas hydrophilic model drugs, nile blue, was loaded within the MPs. PCOX MNs were mounted to the top of a dissolvable poly(N- vinylpyrrolidone)/poly(vinyl alcohol) (PVP/PVA) supporting array, providing mechanical strength to fully insert the MNs into
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19

Yu-KaiLin and 林育楷. "Hyaluronic acid microneedles containing PLGA microparticles as a dual-drug transdermal delivery system for long-term treatment of osteoporosis." Thesis, 2016. http://ndltd.ncl.edu.tw/handle/92j7qx.

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碩士<br>國立成功大學<br>化學工程學系<br>105<br>This study develops an embeddable hyaluronic acid microneedle (HA MN) system containing PLGA microparticles (MPs) as a dual-drug transdermal delivery system for long-term treatment of osteoporosis. Alendronate sodium (ALN) and estradiol (E2)-loaded PLGA MPs are loaded in the HA MN that are connected with a dissolving HA supporting array. When inserted into the skin, the supporting array can provide an extended length to counteract skin deformation for complete insertion of MN and then quickly dissolve in the skin. The MN can be embedded within the skin for sust
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20

Ferreira, Ana Vanessa Fernandes. "Incorporation of elastase inhibitor in silk fibroin nanoparticles for transdermal delivery." Master's thesis, 2013. http://hdl.handle.net/1822/28648.

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Dissertação de mestrado em Bioengenharia<br>Human neutrophil elastase, as inflammatory response, has the capacity to degrade collagen and elastin component of extracellular matrix, being extensively involved in wrinkles formation induced by UV radiation damage. In order to develop a cosmetic antiwrinkling emulsion, we incorporated a potent synthetic HNE inhibitor, sivelestat (IC50 = 44 nM, Ki = 0.2 μM), into biopolymeric nanoparticles prepared by high-energy emulsification methods. As nanomaterial was used Bombyx mori silk fibroin protein, an FDA approved natural biocompatible and biodeg
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21

Lin, Yi-Jou, and 林儀柔. "A Two-Step Controlled Release System Based on The Microneedle array filled with pH-sensitive PLGA hollow microspheres (HMS) for transdermal drug delivery." Thesis, 2011. http://ndltd.ncl.edu.tw/handle/28118117724661515154.

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碩士<br>國立清華大學<br>奈米工程與微系統研究所<br>99<br>Transdermal delivery is an attractive alternative of drug delivery. Comparing to the conventional drug delivery techniques using pills or injections, this approach avoids degradation in the gastrointestinal tract and the pain of injections. But it is limited by the low permeability of skin because the stratum corneum (SC) in the upper skin (10-20 μm) is the main barrier. Hence, we used the Bio-MEMS technique to make microneedle array patch to inset into skin. This microneelde array patch could easily cross the SC but not so long that reach the deeper tissue
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