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1

Patel, Pradeep, K. K Pandey, D. Peepra, and U. Katakwar. "Aneurysmal Bone Cyst of the First Metatarsal Reconstructed Using Non Vascular Free Fibular Graft Transfer - A Case Report." International Journal of Science and Research (IJSR) 11, no. 2 (2022): 34–37. http://dx.doi.org/10.21275/sr22129000229.

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2

Biazotti, Maria Cristina Santoro, Walter Pinto Junior, Maria Cecília Romano Maciel de Albuquerque, et al. "Preimplantation genetic diagnosis for cystic fibrosis: a case report." Einstein (São Paulo) 13, no. 1 (2015): 110–13. http://dx.doi.org/10.1590/s1679-45082015rc2738.

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Cystic fibrosis is an autosomal recessive disorder caused by mutations in the cystic fibrosis transmembrane conductance regulator gene. This disorder produces a variable phenotype including lung disease, pancreatic insufficiency, and meconium ileus plus bilateral agenesis of the vas deferens causing obstructive azoospermia and male infertility. Preimplantation genetic diagnosis is an alternative that allows identification of embryos affected by this or other genetic diseases. We report a case of couple with cystic fibrosis; the woman had the I148 T mutation and the man had the Delta F508 gene
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3

Ferro, Ashley, Meryl Griffiths, Rona Smith, and Andrew Fry. "Acute kidney injury as the presenting complaint of ceftazidime-induced immune-mediated haemolysis." BMJ Case Reports 12, no. 11 (2019): e232884. http://dx.doi.org/10.1136/bcr-2019-232884.

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We present the case of ceftazidime-induced immune-mediated haemolysis with associated acute kidney injury in a 43-year-old woman. The patient initially presented to the regional cystic fibrosis centre for treatment of an infective exacerbation of cystic fibrosis. After initiation of ceftazidime (a third-generation cephalosporin), renal function rapidly deteriorated and a fall in haemoglobin was noted. On transfer to our care, a haemolysis screen identified immune-mediated haemolysis, and renal biopsy confirmed the finding of acute tubular necrosis secondary to haem pigment. The patient’s renal
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4

Nisanci, Mustafa, Ismail Sahin, and Serbulent Guzey. "An Extraordinary Case of Axillary Contracture: Trapped Healthy Skin and Its Adnexes Under Contracted Scar." International Surgery 99, no. 4 (2014): 442–46. http://dx.doi.org/10.9738/intsurg-d-13-00127.1.

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Abstract Although striking improvements have been achieved in overall management of burn injury, postburn contractures are still an ongoing challenge to burn surgeons. Axillary adduction contracture is one of the most common types of these disabling postburn complications that usually result from suboptimal treatment after acute burns. An unusual and complicated case of axillary contracture in which the unburned, healthy axillary dome skin was trapped as a cystic mass under the scarred area was reconstructed by transfer of a big (17 × 13-cm) thoracodorsal artery perforator flap after contractu
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5

Thompson, Christopher St Clair Gaston, Lucy Qian Li, and Alok Sharma. "Coblation of paediatric cystic laryngeal lymphovascular malformations: a safe and effective alternative to tracheostomy." BMJ Case Reports 13, no. 9 (2020): e235596. http://dx.doi.org/10.1136/bcr-2020-235596.

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We describe the case of a 12-hour-old, full-term newborn girl referred to the Ear, Nose and Throat emergency team with increased work of breathing and stridor present at birth. Flexible nasendoscopy revealed a cystic laryngeal lesion obstructing the glottis that prompted securing of the airway with intubation and transfer to a tertiary paediatric centre. On further investigation with MRI and direct visualisation, the lesion was identified as a mixed macro/microcystic laryngeal lymphovascular malformation. The patient successfully underwent a series of microlaryngo–bronchoscopy and coblations o
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6

Prokic, Aleksandra, Minja Milicic-Lazic, and Igor Djordjevic. "Soft tissue management at delayed implant loading in the aesthetic zone: A case report." Serbian Dental Journal 70, no. 4 (2023): 196–202. http://dx.doi.org/10.2298/sgs2304196p.

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Emergence profile of implant-supported crowns is defined by the characteristics of supracrestal connective tissue (SCT), located between the implant platform and cervical soft tissue margin. This paper reflects the soft tissue contour management of implant-supported screw-retained crowns and the transfer of emergence profile using an indirectly customized impression coping. A 27-year-old male was referred for endosseus implant placement (Straumann BLT 0 4.1 mm ? 12 mm) in a region of a maxillary right central and lateral incisor. Teeth were extracted due to a cystic formation in the mentioned
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7

Pribylov, Sergey A., Tatyana A. Maslova, Vladislav S. Pribylov, Kristina O. Leonidova, Nadezhda N. Pribylova, and Anna P. Kuts. "Long-COVID, severe course, with congenital bronchiectasis, Williams–Campbell syndrome. Case report." Terapevticheskii arkhiv 96, no. 11 (2024): 1089–95. https://doi.org/10.26442/00403660.2024.11.202997.

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We present a clinical observation of an 18-year-old female patient with congenital bronchiectasis combined with congenital cystic degeneration of the upper lobes of both lungs, Williams–Campbell syndrome, long-COVID, severe course. The patient was treated in infectious disease department (three times), with subsequent transfer to pulmonology department of Kursk Regional Multi-Purpose Clinical Hospital from 31.01.2023 to 02.05.2023. The patient was going to have lung transplantation, registered in Shumakov Federal Research Center of Transplantology and Artificial Organs earlier. The patient was
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8

Ng, Irene Ai Ting, Hiang Jin Tan, Adrian Kah Heng Chiow, and Thiruchelvam Nita. "Surgical management of rare hepatobiliary sarcomas in a regional teaching hospital: a collaborative model for optimal care with case studies." BMJ Case Reports 17, no. 9 (2024): e260975. http://dx.doi.org/10.1136/bcr-2024-260975.

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Sarcomas are challenging and conventionally referred to sarcoma specialist centres. In select cases with required surgical expertise, collaboration with a quaternary sarcoma centre rather than an upfront transfer of care may reduce logistic challenges without compromising patient care.We present a case series of three rare tumours of hepatobiliary origin—two cases of undifferentiated embryonal liver sarcoma in adults and one case of follicular dendritic sarcoma of the cystic lymph node.All three patients underwent surgery in a non-sarcoma specialist centre by hepatobiliary specialist surgeons
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9

Botticelli, Gianluca, Marco Severino, Gianmaria Fabrizio Ferrazzano, et al. "Excision of Lower Lip Mucocele Using Injection of Hydrocolloid Dental Impression Material in a Pediatric Patient: A Case Report." Applied Sciences 11, no. 13 (2021): 5819. http://dx.doi.org/10.3390/app11135819.

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Oral mucocele is a benign cystic exophytic lesion affecting the minor salivary gland and is especially present in pediatric patients (3% under 14 years). It is characterized by an extravasation or retention of fluid or mucus in the submucosal tissue of the minor salivary glands. Several surgical techniques have been proposed over the years, including the excision of the mucocele by using the injection of a hydrocolloid impression material in the light of the cyst to prevent the collapse of the cystic wall and solidify the lesion, resulting in a better cleavage plan. The combined clinical appro
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10

Wilson, A. M., H. L. Slack, S. A. Soosay, et al. "Lymphangioleiomyomatosis A Series of Three Case Reports Illustrating the Link with High Oestrogen States." Scottish Medical Journal 46, no. 5 (2001): 150–52. http://dx.doi.org/10.1177/003693300104600509.

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Lymphangioleiornyomatosis is a rare lung disorder characterised by cystic air spaces and smooth muscle proliferation. The condition, which most commonly presents with dyspnoea, pneumothoraces or cough, is only described in fernales and is most commonly diagnosed during childbearing years. Three cases are presented which illustrate typical features of the disease and the association with high oestrogen levels. The first had recurrent pneumothoraces during her first pregnancy. The second lady was post menopausal at diagnosis but her symptoms predated her menopause. The third, presented with dysp
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11

Perisse, I. Viotti, Z. Fan, Y. Liu, et al. "205 Towards the correction of meconium ileus with cystic fibrosis transmembrane conductance regulator (CFTR) intestinal expression in CFTR knockout sheep." Reproduction, Fertility and Development 31, no. 1 (2019): 228. http://dx.doi.org/10.1071/rdv31n1ab205.

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Cystic fibrosis (CF) is a human autosomal genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which is responsible for Cl − anion transport in epithelial cells. We previously generated CFTR +/− and CFTR −/− lambs using CRISPR/Cas9 and somatic cell nuclear transfer (SCNT) techniques. The CFTR −/− lambs display many features similar to humans with CF, including meconium ileus (MI), pancreatic fibrosis, portal fibrosis and biliary hyperplasia, small gallbladder, and absence of the vas deferens. Although MI affects only 15 to 20% of human bab
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12

Chinzei, Nobuaki, Noriyuki Kanzaki, Takaaki Fujishiro, et al. "Arthroscopic Debridement of a Talar Cyst and Bone Grafting with the Osteochondral Autograft Transfer System." Journal of the American Podiatric Medical Association 107, no. 6 (2017): 541–47. http://dx.doi.org/10.7547/16-063.

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Simple bone cysts compose approximately 3% of all primary bone tumors and most commonly occur in the metaphyseal regions of the proximal humerus and femur. The percentage of the talus with suspected bone tumors is reported to be 0.003%. Therefore, talar cysts are rare but sometimes present as aggressive lesions, and they can affect any of the tarsal bones. Recently, an arthroscopic approach to these lesions has been developed that is less invasive than conventional open surgery. In the present case study, we profile a 65-year-old female patient who received arthroscopic debridement of a bone c
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13

Slukvin, Igor I., M. Shahriar Salamat, and Sunita Chandra. "Morphologic Studies of the Placenta and Autopsy Findings in Neonatal-onset Glutaric Acidemia Type II." Pediatric and Developmental Pathology 5, no. 3 (2002): 315–21. http://dx.doi.org/10.1007/s10024-001-0213-0.

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A case of neonatal-onset glutaric acidemia type II with electron-transfer flavoprotein (ETF) deficiency is presented. The morphological pattern of disease in the male infant included hypospadias, cryptorchidism, bilateral 13 ribs, nuclear cataract, cystic dysplasia of kidneys, lipid accumulation in the liver and renal tubular epithelium, and immature brain with white matter gliosis. The morphologic examination of the placenta revealed features of delayed maturation, including large-for-gestational-age size and abundant immature intermediate villi with cellular syncytiotrophoblast, persistent v
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14

Thermann, Hajo. "Supramalleolar osteotomy and AMIC cartilage reconstruction in severe cartilage lesion." Foot & Ankle Orthopaedics 3, no. 3 (2018): 2473011418S0048. http://dx.doi.org/10.1177/2473011418s00488.

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Category: Ankle Introduction/Purpose: Severve cartilage lesion is defined by the author as: Cartilage substantial deterioration of the subchondral bone Kissing lesion, tibial and talar lesion. Gross cystic lesion Cartilage damage greater than 1/3 of the talar dome or the tibial platform Slerotic changes of the subchondral bone plate in arthritic cases in severe hindfoot varus or valgus alignment. This paper shows in a case series, exceptional cartilage lesions with the above mentioned pathological changes. The indications, strategies for osteotomies and the treatment strategies in malaligned b
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15

Lim, Yeo Won, Yong Kwon Chae, Ko Eun Lee, et al. "Iatrogenic Incidents in Primary Molar Pulpectomy: A Case Series Report and Literature Review." Applied Sciences 13, no. 19 (2023): 11008. http://dx.doi.org/10.3390/app131911008.

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Pulpectomy is a common treatment for severe carious lesions in primary molars. Care should be taken during pulpectomy of the primary teeth for successive permanent teeth. This case series report aimed to describe the cases of three patients who experienced excessive extrusion of canal filling materials and file separation during primary molar pulpectomy. The presence of separated files or excessive overfilling materials observed around successive permanent tooth germs leads to underdevelopment and may trigger cystic changes owing to abscess formation. The most important aspect is to preserve t
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16

Bunch, K., I. V. Perisse, Z. Fan, K. White, and I. Polejaeva. "95 Invitro correction of F508del and G542X mutations in sheep fibroblasts of cystic fibrosis models." Reproduction, Fertility and Development 33, no. 2 (2021): 155. http://dx.doi.org/10.1071/rdv33n2ab95.

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Cystic fibrosis (CF) is a human genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Among the ∼2000 known CF mutations, the F508del mutation is found in 84% and G542X in 4.6% of the CF patients in the United States. The F508del mutation occurs in exon 11 and is characterised by deletion of the “CTT” nucleotides, resulting in deletion on the phenylalanine residue at the position 508 of CFTR. This causes misfolding of the CFTR protein, which is further degraded by proteases. The G542X mutation is a nonsense mutation found in exon 12 and associated with
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17

Bunch, K., I. V. Perisse, Z. Fan, K. White, and I. Polejaeva. "95 Invitro correction of F508del and G542X mutations in sheep fibroblasts of cystic fibrosis models." Reproduction, Fertility and Development 33, no. 2 (2021): 155. http://dx.doi.org/10.1071/rdv33n2ab95.

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Cystic fibrosis (CF) is a human genetic disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Among the ∼2000 known CF mutations, the F508del mutation is found in 84% and G542X in 4.6% of the CF patients in the United States. The F508del mutation occurs in exon 11 and is characterised by deletion of the “CTT” nucleotides, resulting in deletion on the phenylalanine residue at the position 508 of CFTR. This causes misfolding of the CFTR protein, which is further degraded by proteases. The G542X mutation is a nonsense mutation found in exon 12 and associated with
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18

Slotki, I. N., W. V. Breuer, R. Greger, and Z. I. Cabantchik. "Long-term cAMP activation of Na(+)-K(+)-2Cl- cotransporter activity in HT-29 human adenocarcinoma cells." American Journal of Physiology-Cell Physiology 264, no. 4 (1993): C857—C865. http://dx.doi.org/10.1152/ajpcell.1993.264.4.c857.

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Cl- channel and Na(+)-K(+)-2Cl- cotransport activities were studied in various cystic fibrosis transmembrane conductance regulator (CFTR)-expressing cells with the aim of assessing integrative patterns of regulation of Cl- secretion. Human colonic HT-29 cells express relatively high levels of CFTR and cotransporter but relatively low Cl- channel activity. These cells showed commensurate activations of both transport systems evoked by short-term (minutes) or long-term (hours) exposures to adenosine 3',5'-cyclic monophosphate (cAMP). However, unlike in the case of CFTR and Cl- channels, long-ter
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19

Jiang, S. X., T. Murray, V. T. Leung, and G. Ou. "A137 AN ELUSIVE GASTROINTESTINAL BLEED: A CASE OF RUPTURED CYSTIC ARTERY PSEUDOANEURYSM WITH PREVIOUS BILLROTH-II SURGERY." Journal of the Canadian Association of Gastroenterology 5, Supplement_1 (2022): 8–10. http://dx.doi.org/10.1093/jcag/gwab049.136.

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Abstract Background Cystic artery pseudoaneurysm (CAP) is a rare but potentially life-threatening cause of upper gastrointestinal (GI) bleeding and requires urgent intervention. Aims To describe the clinical enigma of CAP in the context of distorted anatomy and discuss management. Methods Case report and review of literature Results Case Report A healthy 91-year-old man with a remote history of gastric ulcer perforation leading to Billroth-II surgery 40 years ago presented to a community hospital with melena. He had no abdominal pain and liver enzymes were normal. His hemoglobin was 97 g/L (fr
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20

Simonova, Olga I., O. L. Voronina, Yu V. Gorinova, et al. "Features of the treatment of the cystic fibrosis patient with mixed microbial respiratory infection, including Pandoraea Pnomenusa." Russian Pediatric Journal 19, no. 2 (2019): 113–22. http://dx.doi.org/10.18821/1560-9561-2016-19-2-113-122.

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Respiratory tract infection is a major cause of complications and death in patients with cystic fibrosis (CF). Transmissible strains of Gram-negative non-fermenting Burkholderiales bacteria: Burkholderia cepacia complex, Achromobacter spp, Pandoraea spp. are quite alarming. In the paperfirstly there is presented a clinical case with mixed microbial infection of the CF patient with involvement of Pandoraea pnomenusa. There are reportedfeatures of diagnosis and treatment of a patient throughout 20 years, described the data of the examination of the patient and his airway microbiota. Timely ident
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Wallner, K., A. Wuensch, K. Burkhardt, et al. "338 BACTERIAL ARTIFICIAL CHROMOSOME (BAC) VECTORS FACILITATE EFFICIENT GENE TARGETTING IN KIDNEY CELLS OF PIG." Reproduction, Fertility and Development 23, no. 1 (2011): 264. http://dx.doi.org/10.1071/rdv23n1ab338.

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Site-directed mutagenesis provided a powerful tool for studying gene functions in mice, but the lack of embryonic stem cells in other species limited the application of this technology to other species. Various attempts using negative selection, viral vectors, or other auxiliary means promoted specific projects but did not provide methods for routine experiments. Here, we describe a novel approach that enabled the site-directed modification of 3 different porcine genes relevant for biomedical research. Three main technologies were combined to achieve these goals: bacterial artificial chromosom
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Park, Won-Bae, and Hyun-Chang Lim. "Late Developed Unusual Nasal Involvement of Postoperative Maxillary Cyst Following Maxillary Sinus Augmentation: A Case Report." Applied Sciences 11, no. 22 (2021): 10730. http://dx.doi.org/10.3390/app112210730.

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Postoperative maxillary cyst (POMC) is a benign expansive cystic lesion of the maxilla generally related to invasive maxillary surgeries or trauma. POMC can also develop after maxillary sinus augmentation (MSA), but many dentists are not well-aware of such complication of MSA. A 56-year-old male patient had undergone bilateral MSA. After 18 years, the patient reported painless swelling on the left palate. On the panoramic radiographs, no specific findings were found, but a large unilocular lesion was detected at the medial side of the previous augmentation of the left maxillary sinus on cone-b
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23

Harvey, Ben-Gary, Neil R. Hackett, Tarek El-Sawy, et al. "Variability of Human Systemic Humoral Immune Responses to Adenovirus Gene Transfer Vectors Administered to Different Organs." Journal of Virology 73, no. 8 (1999): 6729–42. http://dx.doi.org/10.1128/jvi.73.8.6729-6742.1999.

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ABSTRACT Administration of adenovirus (Ad) vectors to immunologically naive experimental animals almost invariably results in the induction of systemic anti-Ad neutralizing antibodies. To determine if the human systemic humoral host responses to Ad vectors follow a similar pattern, we evaluated the systemic (serum) anti-Ad serotype 5 (Ad5) neutralizing antibodies in humans after administration of first generation (E1− E3−) Ad5-based gene transfer vectors to different hosts. AdGVCFTR.10 (carrying the normal human cystic fibrosis [CF] transmembrane regulator cDNA) was sprayed (8 × 107 to 2 × 101
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24

Long, Xing-Yu, Feng Sun, Tao Wang, Ping Li, Zhong Tian, and Xian-Wei Wu. "Ilizarov technique for treatment of a giant aneurysmal bone cyst at the distal femur: A case report." World Journal of Orthopedics 15, no. 11 (2024): 1088–94. http://dx.doi.org/10.5312/wjo.v15.i11.1088.

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BACKGROUND Aneurysmal bone cyst (ABC) is a benign cystic of unknown etiology, characterized by multiple chambers and a high recurrence rate. Current treatment options include vascular embolization, surgical excision, curettage with cavity filling, sclerosing agent injection into the cavity, radiotherapy, and systemic drug therapy. Among these, surgical excision and curettage are the preferred treatment modalities. However, when the cyst reaches a large size, extensive removal of diseased tissue during surgery can hinder bone healing. In our department, we treated a case of a large ABC at the d
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25

Viotti Perisse, I., Z. Fan, A. Van Wettere, et al. "132 Introduction of F508del human mutation into the CFTR gene of sheep fetal fibroblasts using CRISPR/Cas9 ribonucleoprotein." Reproduction, Fertility and Development 32, no. 2 (2020): 192. http://dx.doi.org/10.1071/rdv32n2ab132.

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Cystic fibrosis (CF) is an autosomal recessive genetic disease that affects over 30 000 people in the United States and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. The CFTR protein is a cAMP-regulated C− channel responsible for regulation of anion transport, primarily in the epithelial cells. We have previously generated a sheep model of CF by genetically inactivating the CFTR gene (Fan et al. 2018 JCI Insight 3, e123529). The newborn CFTR −/− sheep develops severe disease consistent with CF pathology in humans. The CF model is extremely valua
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26

Lee, Jin Woo. "New Perspectives of Osteochondral Lesion of the Talus." Orthopaedic Journal of Sports Medicine 7, no. 11_suppl6 (2019): 2325967119S0045. http://dx.doi.org/10.1177/2325967119s00453.

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Osteochondral lesions of the talus(OLT) are the most common articular cartilage defects in the ankle and may cause disability as a result of chronic pain and limited weight-bearing capacity. Numerous treatment strategies for symptomatic OLT have advanced significantly over the past decades. OLT are often managed conservatively for an initial stage before the surgical treatment. However, the conservative management determined solely on symptomatology, and not on the physiological healing. A systematic review for the treatment of OLT demonstrated a 45% success rate of non-operative management. S
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27

Maule, Giulia, Daniele Arosio, and Anna Cereseto. "Gene Therapy for Cystic Fibrosis: Progress and Challenges of Genome Editing." International Journal of Molecular Science 21, no. 11 (2020). https://doi.org/10.3390/ijms21113903.

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<strong>Abstract</strong> Since the early days of its conceptualization and application, human gene transfer held the promise of a permanent solution to genetic diseases including cystic fibrosis (CF). This field went through alternated periods of enthusiasm and distrust. The development of refined technologies allowing site specific modification with programmable nucleases highly revived the gene therapy field. CRISPR nucleases and derived technologies tremendously facilitate genome manipulation offering diversified strategies to reverse mutations. Here we discuss the advancement of gene ther
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Yang, Dongshan, Xiubin Liang, Brooke Pallas та ін. "Production of CFTR-ΔF508 Rabbits". Frontiers in Genetics 11 (22 січня 2021). http://dx.doi.org/10.3389/fgene.2020.627666.

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Cystic Fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the gene encoding the cystic fibrosis transmembrane conductance regulator (CFTR). The most common mutation is the deletion of phenylalanine residue at position 508 (ΔF508). Here we report the production of CFTR-ΔF508 rabbits by CRISPR/Cas9-mediated gene editing. After microinjection and embryo transfer, 77 kits were born, of which five carried the ΔF508 mutation. To confirm the germline transmission, one male ΔF508 founder was bred with two wild-type females and produced 16 F1 generation kits, of which six are
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Okamoto, Mitsumasa, Shoka Kimura, Machiko Hotta, Yudai Tsuruno, and Hiroaki Fukuzawa. "Infantile type I pleuropulmonary blastoma presenting with dyspnea due to compression by pneumothorax and an occupying tumor: a case report." Surgical Case Reports 9, no. 1 (2023). http://dx.doi.org/10.1186/s40792-023-01777-7.

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Abstract Background Pleuropulmonary blastoma (PPB) is an extremely rare and malignant pediatric lung tumor. Purely cystic PPB has a more favorable prognosis than solid PPB, but may be difficult to distinguish from a certain type of “benign” congenital pulmonary airway malformation before and during surgery. The influence of tumor rupture on long life prognosis has not been clarified in detail. Case presentation A 5-month-old boy underwent emergency transfer from another hospital due to a left thoracic cystic lesion and left pneumothorax detected on chest radiography performed for persistent wh
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Tetikkurt, Cuneyt, Deniz Ongel, and Seza Tetikkurt. "A case of bleomycin-induced lung toxicity." Monaldi Archives for Chest Disease 88, no. 3 (2018). http://dx.doi.org/10.4081/monaldi.2018.981.

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A 64-year-old female was admitted for dry cough, dyspnea, fever, loss of appetite, and weight loss. Past medical history revealed scoliosis, cholecystectomy, and Hodgkin lymphoma. ABG values were: pH: 7.42, pCO2: 40.2 mm Hg, pO2: 61.4 mm Hg. Chest CT showed cystic lesions, emphysema, ground glass, and reticular opacities. ABG values worsened under 8L/min nasal oxygen. The patient underwent bilevel positive airway pressure (BiPAP) and methylprednisolone 60 mg/day bid was commenced. The final diagnosis was respiratory insufficiency due to bleomycin toxicity. The patient deceased on the sixth day
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BITICA, Diana-Geanina, Daniel BEREAN, Ovidiu GIURGIU, Raluca CIMPEAN, Simona CIUPE, and Liviu-Marian BOGDAN. "Selection of embryo recipients, a real challenge in cows embryo transfer programs." Interciencia, 2023. http://dx.doi.org/10.59671/3pcds.

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This article comes as a response to a clinical situation that the members of our team found at an embryo transfer program. At the moment of insemination, day 7 after estrus period, a high number of untransferable recipients was found after ovaries ultrasonography. From 54 animals synchronized, just in 5 (9.25 %) cases was performed the embryo insemination. The embryo transfer was performed in cases where a corpus luteum (CL group) higher than 17 mm was found on the ovary, corpus luteum with a cavity of a maximum 10 mm and without a follicle higher than 10 mm on the ovary with the corpus luteum
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Yan, Limin, Jinheng Xu, Liyun Liu, and Xin Li. "Warthin-like mucoepidermoid carcinoma of the parotid gland: Clinicopathological observation and literature review." Science Progress 106, no. 2 (2023). http://dx.doi.org/10.1177/00368504231179816.

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Warthin tumor (WT)-like mucoepidermoid carcinoma resembles the histologic pattern of WT and pathologists unaware of this possibility may misdiagnose it as WT with squamous and mucous epithelium metaplasia or WT malignant transfer into mucoepidermoid carcinoma. The present study reported a case of a 41-year-old Chinese female with a solitary mass in the left parotid gland. In this case, microscopic observation revealed prominent lymph node stroma and multiple cystic structures similar to those seen in WT. However, it lacked the two layers of oncocytic epithelial tissue characteristic of WT. Fur
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Loap, Pierre, Barbara Vischioni, Maria Bonora, et al. "Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review." Frontiers in Oncology 11 (November 30, 2021). http://dx.doi.org/10.3389/fonc.2021.789079.

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Adenoid cystic carcinoma (ACC) is a rare, basaloid, epithelial tumor, arising mostly from salivary glands. Radiation therapy can be employed as a single modality for unresectable tumors, in an adjuvant setting after uncomplete resection, in case of high-risk pathological features, or for recurrent tumors. Due to ACC intrinsic radioresistance, high linear energy transfer (LET) radiotherapy techniques have been evaluated for ACC irradiation: while fast neutron therapy has now been abandoned due to toxicity concerns, charged particle beams such as protons and carbon ions are at present the beams
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34

Rieger, Martin, Harald Mauch, and Regine Hakenbeck. "Long Persistence of a Streptococcus pneumoniae 23F Clone in a Cystic Fibrosis Patient." mSphere 2, no. 3 (2017). http://dx.doi.org/10.1128/msphere.00201-17.

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ABSTRACT Streptococcus pneumoniae is a common resident in the human nasopharynx. However, carriage can result in severe diseases due to a unique repertoire of pathogenicity factors that are rare in closely related commensal streptococci. We investigated a penicillin-resistant S. pneumoniae clone of serotype 23F isolated from a cystic fibrosis patient on multiple occasions over an unusually long period of over 3 years that was present without causing disease. Genome comparisons revealed an apparent nonfunctional pneumococcus-specific gene encoding a hyaluronidase, supporting the view that this
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Crowley, Clare Margaret, Nyan Chin Liew, Consol Plans, Sinead O’Brien, and Mendinaro Imcha. "Successful multi-disciplinary management of anti-NMDAR encephalitis during pregnancy." Obstetric Medicine, September 20, 2023. http://dx.doi.org/10.1177/1753495x231190594.

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The comorbid presentation of anti-NMDAR encephalitis with ovarian teratomas was first described in 2005. The incidence of anti-NMDAR encephalitis during pregnancy is rare, with 16 cases reported to date. We describe the case of a 31-year-old nulliparous woman who presented with status epilepticus in early pregnancy and was subsequently diagnosed with anti-NMDAR encephalitis. The inter-hospital transfer was required for higher-level care and ventilation. A comprehensive work-up identified anti-NMDAR antibodies in both serum and cerebrospinal fluid. Pelvic imaging showed a unilateral ovarian cys
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Goodlet, Kellie J., Rhiannon Garcia, and Michael D. Nailor. "Universal azole prophylaxis for prevention of coccidioidomycosis among lung transplant recipients transferring care to a center within a highly endemic region." Transplant Infectious Disease, September 23, 2024. http://dx.doi.org/10.1111/tid.14379.

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AbstractBackgroundCoccidioidomycosis may cause severe disseminated disease and mortality among lung transplant recipients. A strategy of lifelong azole prophylaxis was previously associated with low rates of coccidioidomycosis. Whether lung transplant recipients relocating to the Coccidioides endemic region are also at risk and would benefit from antifungal prophylaxis is unknown.MethodsLung transplant recipients transplanted at an outside center with low Coccidioides endemicity before relocating for post‐transplant follow‐up at a transplant center in Phoenix, Arizona from January 2013 to Marc
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Matsui, Yusuke, Satoshi Shiono, Masahiro Mizumoto, et al. "Surgical management of a huge mediastinal mature teratoma in a 2-year-old girl: a case report." General Thoracic and Cardiovascular Surgery Cases 3, no. 1 (2024). https://doi.org/10.1186/s44215-024-00181-3.

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Abstract Background Mature teratomas are benign cystic tumors that are most commonly asymptomatic. However, in some cases, mediastinal teratomas rupture the lungs and mediastinum with potentially fatal outcomes. Herein, we report a case of a large mediastinal mature teratoma that expanded to the entire left hemithorax in a child with common cold-like symptoms. Case presentation. A 2-year-7-month old girl visited a family doctor because of cough and rhinorrhea. Chest radiography revealed a large tumor occupying the left hemithorax, necessitating transfer to our institution. Chest computed tomog
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Wang, Shao-Jing, Li-Ling Lin, and Wei-Chih Chen. "Placental mesenchymal dysplasia complicated with sudden fetal demise and amniotic fluid embolism: a case report." BMC Pregnancy and Childbirth 22, no. 1 (2022). http://dx.doi.org/10.1186/s12884-022-05261-2.

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Abstract Background Placenta mesenchymal dysplasia (PMD) is a rare placental anomaly associated with various fetal and maternal complications. Whether close ultrasound surveillance can prevent intrauterine fetal demise (IUFD) in patients with PMD is still under investigation. Amniotic fluid embolism (AFE) is a rare, lethal, and unpredictable maternal complication that has never been described in association with PMD. Here, we report a case of PMD, in which the fetus eventually demised in utero despite weekly color Doppler monitoring, and the mother subsequently encountered AFE during delivery.
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Baba, Tokuro, Toru Yamazaki, Masato Sakai, et al. "A possible manifestation of pancreas divisum–pancreatic pseudocyst in an infant with no apparent history of pancreatitis: a case report." Surgical Case Reports 9, no. 1 (2023). http://dx.doi.org/10.1186/s40792-023-01735-3.

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Abstract Background Pancreas divisum (PD), the most common pancreatic anomaly, is caused by the failure of pancreatic bud fusion in the embryo. Although most cases are asymptomatic, it can cause pancreatitis or epigastric pain. We report an unusual case of PD in an infant. Case presentation The patient was a 9-month-old girl with no pertinent medical history. She had suffered vomiting and diarrhea for 1 week before transfer to our hospital. Her general condition was poor, and abdominal distention was noted. Blood tests revealed microcytic anemia with normal chemical markers. The parents report
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Zhang, Jing, Xun Liu, Mo Zheng, Jing Yin, and Weibin Xing. "Case Report: Dermoscopic, High-Frequency Ultrasound, Contrast-Enhanced Ultrasound Appearances and Special Treatment of a Patient With Syringoid Eccrine Carcinoma on the Chest." Frontiers in Oncology 11 (November 15, 2021). http://dx.doi.org/10.3389/fonc.2021.717581.

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This article aims to explain the use of a variety of noninvasive of minimally invasive examinations to obtain reliable diagnostic clues. The choice of treatment methods and repair techniques for wound defects are also critical in terms of the prognosis. Here, we describe the case of a 53-year-old male patient who visited our dermatology clinic due to a red plaque on the inner side of his left nipple without any symptoms for more than 30 years. He was given dermoscopy, high-frequency ultrasound (HFUS), Color Doppler flow imaging (CDFI), and contrast-enhanced ultrasound (CEUS) examinations. Curr
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Choudhury, Anjishnu, Marcel Filoche, Neil M. Ribe, Nicolas Grenier, and Georg F. Dietze. "On the role of viscoelasticity in mucociliary clearance: a hydrodynamic continuum approach." Journal of Fluid Mechanics 971 (September 21, 2023). http://dx.doi.org/10.1017/jfm.2023.682.

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We present numerical and analytical predictions of mucociliary clearance based on the continuum description of a viscoelastic mucus film, where momentum transfer from the beating cilia is represented via a Navier-slip boundary condition introduced by Bottier et al. (PLoS Comput. Biol., vol. 13, issue 7, 2017a, e1005552). Mucus viscoelasticity is represented via the Oldroyd-B model, where the relaxation time and the viscosity ratio have been fitted to experimental data for the storage and loss moduli of different types of real mucus, ranging from healthy to diseased conditions. We solve numeric
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Core, Daniel, Hayley Vervaeke, Kenna Leethy, and Danielle Cooper. "A Case of Partial Molar Pregnancy Complicated by HELLP and PRES." North American Proceedings in Gynecology & Obstetrics, June 28, 2024. http://dx.doi.org/10.54053/001c.121010.

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Introduction: The term gestational trophoblastic disease encompasses premalignant and malignant conditions arising from trophoblastic cells. Premalignant disorders include complete or partial hydatidiform mole, whereas malignant disorders include invasive mole, choriocarcinoma, and placental-site trophoblastic tumor. Partial hydatidiform moles are triploid in nature and occur when 2 sperm fertilize a single ovum. Preeclampsia is a syndrome complicating 2-8% of pregnancies which presents as new-onset hypertension plus proteinuria. The occurrence of hemolysis, elevated liver enzymes and low plat
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Mazori, Alon Y., Emily S. Markovic, and Carol J. Levy. "SAT134 CGM Use During Pregnancy Complicated By CF-Induced Diabetes." Journal of the Endocrine Society 7, Supplement_1 (2023). http://dx.doi.org/10.1210/jendso/bvad114.999.

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Abstract Disclosure: A.Y. Mazori: None. E.S. Markovic: None. C.J. Levy: Advisory Board Member; Self; Dexcom, Eli Lilly &amp; Company. Research Investigator; Self; Abbott Laboratories, Insulet Corporation, Tandem Diabetes Care, Dexcom. Introduction: Glycemic control remains challenging in pregnancies complicated by diabetes mellitus. Strict glycemic targets are required to optimize maternal and neonatal outcomes, but euglycemia is hindered by fluctuating insulin sensitivity and the need for frequent blood-glucose monitoring (BGM). Consensus guidelines recommend therapeutic continuous glucose mo
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Nadeem, Nabeegh, Jenifer Barrie, Richard Bell, and Nehal Shah. "P-P50 Analysis of the efficiency of the hepatobiliary multidisciplinary team meeting to identify quality improvement strategies." British Journal of Surgery 108, Supplement_9 (2021). http://dx.doi.org/10.1093/bjs/znab430.272.

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Abstract Background The multidisciplinary team meeting is the mainstay of management of patients with hepatopancreatobiliary (HPB) cancer and is considered the gold standard of care. Disadvantages of these meetings include large numbers of patients to be discussed covering multiple super-specialities over a short time span. This can lead to decision fatigue amongst clinicians. Logistical factors such as information technology and presence of clinicians with relevant expertise may also hamper the progress of the meeting. The aim of this study was to analyse the efficiency of our HPB MDT with a
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Huckerby, Lauren, Janet E. McDonagh, and Rebecca R. Lee. "P05 The current evidence for transitional care in young people with chronic pain: a systematic review." Rheumatology Advances in Practice 6, Supplement_1 (2022). http://dx.doi.org/10.1093/rap/rkac067.005.

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Abstract Introduction/Background Paediatric chronic musculoskeletal pain presents a significant individual and societal burden, with an estimated prevalence of 11-38%. A large proportion of young people (YP) with chronic pain are likely to have unresolved pain which continues into adulthood and as a result require transitional care. To date, although there is guidance and transitional care research in a range of health conditions, there is limited evidence identifying the extent to which transitional care for YP with chronic pain has been developed or investigated in research. Our objective wa
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sprotocols. "Engineering of ultra-small diagnostic nanoprobes through oriented conjugation of single-domain antibodies and quantum dots." January 7, 2015. https://doi.org/10.5281/zenodo.13799.

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Authors: Alyona Sukhanova, Klervi Even-Desrumeaux, Patrick Chames, Daniel Baty, Mikhail Artemyev, Vladimir Oleinikov &amp; Igor Nabiev ### Abstract Nanoparticle-based biodetection commonly employs monoclonal antibodies (mAbs) for targeting. Although several types of conjugates have been used for biomarker labeling, the large size of mAbs limits the number of ligands per nanoparticle, impedes their intratumoral distribution, and limits intracellular penetration. Furthermore, the conditions of mAb conjugation using conventional techniques provide nanoprobes with irregular orientation of mAbs on
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